20261Global, regional, and national burden of chronic respiratory diseases and impact of the COVID-19 pandemic, 1990–2023: a Global Burden of Disease studyJ. S. Oh; Soeun Kim; Yesol Yim; Min Seo Kim; GBD 2023 Global Chronic Respiratory Disease and Covid Collaborators; Jae il Shin; Ahmed A. J. Jabbar; Hasan Aalruz; Mohammadreza Abbasian; Abdallah H A Abd Al Magied; Samar Abd ElHafeez; Atef Ben Abdelkader; Mawada Hassan Abdelmagied; Parsa Abdi; Mohammad‐Amin Abdollahifar; Deldar Morad Abdulah; Auwal Abdullahi; Nigusie Abebaw; Roberto Ariel Abeldaño Zúñiga; Richard Gyan Aboagye; Hassan Abolhassani; Mohamed Abouzid; Lucas Guimarães Abreu; Dariush Abtahi; Rana Kamal Abu Farha; Ibrahim Jatau Abubakar; Abu- Gharbieh E; Hana J. Abukhadijah; Salahdein Aburuz; Ahmed Abu-Zaid; Juan Manuel Acuna; Mesafint Molla Adane; Isaac Yeboah Addo; Oyelola A. Adegboye; Victor Adekanmbi; Charles Oluwaseun Adetunji; Temitayo Esther Adeyeoluwa; Rishan Adha; Kishor Kumar Adhikari; Ripon Kumar Adhikary; Qorinah Estiningtyas Sakilah Adnani; Aanuoluwapo Adeyimika Afolabi; Rotimi Felix Afolabi; Fatemeh Afrashteh; Arya Afrooghe; Anurag A. Agrawal; Williams Agyemang‐Duah; Aqeel Ahmad; Muayyad Ahmad; Sajjad Ahmad; Shahzaib Ahmad; Ali Reza Ahmadi; Ayman Ahmed; Haroon Ahmed; İbrar Ahmed; Mohammed Ahmed; Oli Ahmed; Sindew Mahmud Ahmed; Syed Anees Ahmed; Abdullateef Abiodun Ajadi; Ruslan Akhmedullin; Karolina Akinosoglou; Mohammed Ahmed Al-Kaif; Ashley E Akrami; Hanadi Al Hamad; Syed Mahfuz Al Hasan; Muaaz Alajlani; Yazan A. Al-Ajlouni; Khurshid Alam; Mohammad Khursheed Alam; Nazmul Alam; Rasmieh Al‐Amer; Ayman Al‐Eyadhy; Abdelazeem M. Algammal; Adel Al‐Gheethi; Fadwa Naji Alhalaiqa; Endale Alemayehu Ali; Mohammad Daud Ali; Mohammed Usman Ali; Rafat Ali; Syed Shujait Ali; Waad Ali; Sultan A. Al-Ibraheem; Sheikh Mohammad Alif; Samah W. Al-Jabi; Mohamad Aljofan; Syed Mohamed Aljunid; Sabah Al-Marwani; Hesham M. Al-Mekhlafi; Mohmmad Minwer Alnaeem; Mahmoud A. Alomari; Jaber S. Alqahtani; Abdullah A. Alqarni; Ahmad Alrawashdeh; Sahel Majed Alrousan; Mohammed Alsabri; Najim Alshahrani; Zaid Altaany; Awais Altaf; Khaled Altartoor

Asthma; Respiratory system; Respiratory disease; Incidence (geometry); Disease burden; Burden of disease; Pandemic; Risk factor; Medicine; Environmental health; Intensive care medicine; Body mass index; Disease; Mortality rate; COPD; Cause of death; Global health; Internal medicine; Pulmonary disease

2026-01-01https://doi.org/10.1038/s41591-025-04077-9Nature Medicine 20261Operational agricultural water management in river-based aquaculture: A machine-learning approach to predict dissolved oxygen in the Halda River, BangladeshDissolved Oxygen (DO) represents a key operational constraint for river-dependent aquaculture, and short-term DO forecasting can support practical agricultural water management in systems that directly abstract river water. Relying on daily physicochemical observations from the Halda River, Bangladesh (April 2024–March 2025), four Machine Learning (ML) models were evaluated for DO prediction, i.e. Linear Regression, Artificial Neural Network, Support Vector Machine, and Random Forest. Among the latter ML models, Random Forest achieved the highest predictive performance (R² = 0.9015, RMSE = 0.0833, and MAE = 0.0574), substantially outperforming the considered baseline Linear Regression model (R² = 0.4469, RMSE = 0.1892, and MAE = 0.1478). DO was generally stable (about 6.3–7.0 mg/L) while ionic variables, e.g., chloride, conductivity, and Total Dissolved Solids (TDS), showed pronounced dry-season peaks, thus indicating conditions where oxygen stress can become more likely and less predictable. Explainable ML interpretation developed on feature importance and SHapley Additive exPlanations (SHAP) consistently identified water temperature and ionic concentration proxies, especially chloride, alongside conductivity, and TDS, as the dominant drivers of DO variability. Relying on the latter findings, an operational decision-support workflow is proposed in which forecasts based on the Random Forest ML model are paired with low-cost monitoring of temperature and chloride to trigger time-graded farm actions, such as targeted aeration, temporary intake closure, and stocking/feeding adjustments. The reported results in the developed study demonstrate a transferable pathway for moving from accurate and interpretable ML forecasts to actionable agricultural water management protocols that reduce risk of critical losses in river-based aquaculture.Abdullah Al Mamun Hridoy; Paolo Pastorino; Chiara Bordin; Matteo Bodini; Nayan Dhar; Petra Schneider; Leonardo Goliatt; Pakorn Ditthakit; Bruno da Silva Macêdo; Khairul Nizam Abdul Maulud

Farm water; Agriculture; Water quality; Agricultural management; Water pollution; Water treatment; Environmental science; Environmental engineering; Water resource management; Current (fluid)

2026-01-16https://doi.org/10.1016/j.aquaeng.2026.102693Aquacultural Engineering 20261A benchmark of expert-level academic questions to assess AI capabilitiesBenchmarks are important tools for tracking the rapid advancements in large language model (LLM) capabilities. However, benchmarks are not keeping pace in difficulty: LLMs now achieve more than 90% accuracy on popular benchmarks such as Measuring Massive Multitask Language Understanding1, limiting informed measurement of state-of-the-art LLM capabilities. Here, in response, we introduce Humanity’s Last Exam (HLE), a multi-modal benchmark at the frontier of human knowledge, designed to be an expert-level closed-ended academic benchmark with broad subject coverage. HLE consists of 2,500 questions across dozens of subjects, including mathematics, humanities and the natural sciences. HLE is developed globally by subject-matter experts and consists of multiple-choice and short-answer questions suitable for automated grading. Each question has a known solution that is unambiguous and easily verifiable but cannot be quickly answered by internet retrieval. State-of-the-art LLMs demonstrate low accuracy and calibration on HLE, highlighting a marked gap between current LLM capabilities and the expert human frontier on closed-ended academic questions. To inform research and policymaking upon a clear understanding of model capabilities, we publicly release HLE at https://lastexam.ai . Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.Taom Sakal; Alice Gatti; Nathaniel Li; Adam Khoja; Ryan Kim; Richard Ren; Jason Hausenloy; Oliver Zhang; Mantas Mazeika; Dan Hendrycks; Scale AI; Ziwen Han; Jing Hu; Hugh Zhang; Chen Zhang; Mohamed Shaaban; John Ling; Sean X. Shi; Michael Choi; A. Agrawal; Arnav Chopra; Aakaash Nattanmai; Gordon McKellips; Anish Cheraku; Asim Suhail; Ethan Luo; Marvin Deng; Jason Luo; Ashley Zhang; Kavin Jindel; Jay Paek; Kasper Halevy; Allen Baranov; Michael Liu; Advaith Avadhanam; David Zhang; Vincent Cheng; Brad Ma; Evan Fu; Liam Do; Joshua Laß; Hubert Yang; Surya Sunkari; Vishruth Bharath; Violet Ai; James Leung; Rishit Agrawal; Alan Zhou; Kevin Chen; Tejas Kalpathi; Ziqi Xu; Gavin Wang; Tyler Xiao; Erik Maung; Sam Lee; Ryan Yang; Roy Yue; Ben Zhao; Julia Yoon; Xiangwan Sun; Aryan Singh; Clark Peng; Tyler Osbey; Taozhi Wang; Daryl Echeazu; Timothy Wu; Spandan Patel; Vidhi Kulkarni; Vijaykaarti Sundarapandiyan; Andrew Le; Zafir Nasim; Srikar Yalam; Ritesh Kasamsetty; Soham Samal; David Sun; Nihar Shah; Abhijeet Saha; Alex Zhang; Leon Nguyen; Laasya Nagumalli; Kaixin Wang; Aidan Wu; Anwith Telluri; Summer Yue; Alexandr Wang; Dmitry Dodonov; Tung Nguyen; J Lee; Daron Anderson; Mikhail Doroshenko; Alun Cennyth Stokes; Mobeen Mahmood; Oleksandr Pokutnyi; O. Z. Iskra; Yi-Xiang Wang; J Levin; Mstyslav Kazakov; Fiona Feng; Steven Y. Feng; Haoran Zhao

Grading (engineering); Pace; Benchmark (surveying); Computer science; Limiting; Frontier; Humanity; Data science; Political science; Engineering; Law; Cartography

2026-01-28https://doi.org/10.1038/s41586-025-09962-4Nature 20261Global burden of amphetamine, cannabis, cocaine and opioid use in 204 countries, 1990–2023: a Global Burden of Disease StudyMasayuki Teramoto; Hyeon Jin Kim; Min Suk Kim; GBD 2023 Substance Use Collaborators; Jae Il Shin; Hasan Aalruz; Yohannes Habtegiorgis Abate; Nasir Abbas; Mohammadreza Abbasian; Samar Abd ElHafeez; Michael Abdelmasseh; Arash Abdollahi; Mohammad Abdollahi; Meriem Abdoun; Roberto Ariel Abeldaño Zúñiga; Olugbenga Olusola Abiodun; Olumide Abiodun; Richard Gyan Aboagye; Dariush Abtahi; Ibrahim Jatau Abubakar; Bilyaminu Abubakar; Eman Abu-Gharbieh; Salahdein Aburuz; Ahmed Abu-Zaid; Mesafint Molla Adane; Isaac Yeboah Addo; Olumide Thomas Adeleke; Habeeb Omoponle Adewuyi; Temitayo Esther Adeyeoluwa; Kishor Adhikari; Muhammad Sohail Afzal; Saira Afzal; Williams Agyemang‐Duah; Aqeel Ahmad; Sajjad Ahmad; Danish Ahmad; Ali Ahmadi; Syed Anees Ahmed; Haroon Ahmed; Muktar Beshir Ahmed; Ayman Ahmed; Mehrunnisha Sharif Ahmed; Mohammed Ahmed Al-Kaif; Muaaz Alajlani; Rasmieh Al‐Amer; Mohammed ALBashtawy; Wafa Ali Aldhaleei; Abdelazeem M. Algammal; Fadwa Naji Alhalaiqa; Mohammed Usman Ali; Liaqat Ali; Syed Shujait Ali; Mohammad Daud Ali; Sheikh Mohammad Alif; Samah W. Al-Jabi; Ahmad Alrawashdeh; Rami H Hani Al-Rifai; Sahel Majed Alrousan; Najim Alshahrani; Alaa B. Al-Tammemi; Yazan Al Thaher; Nelson Alvis-Guzmán; Mohammad Al-Wardat; Yaser Mohammed Al-Worafi; Hany Aly; Karem H. Alzoubi; Walid A. Al-Zyoud; Sohrab Amiri; Mohammad Amrollahi-Sharifabadi; Ganiyu Adeniyi Amusa; Abhishek Anil; Carl Abelardo T. Antonio; Catherine M Antony; Iyadunni Adesola Anuoluwa; Boluwatife Stephen Anuoluwa; Jalal Arabloo; Ana Margarida Araújo; Irfan Ardani; Demelash Areda; Benedetta Armocida; Mahwish Arooj; Anton A Artamonov; Mohammad Asghari-Jafarabadi; Tahira Ashraf; Muhammad Shahzad Aslam; Seyyed Shamsadin Athari; Alok Atreya; Avinash Aujayeb; Lemessa Assefa A Ayana; Ahmed Y. Azzam; Nayereh Baghcheghi; Nasser Bagheri; Razieh Bahreini; Ruhai Bai; Atif Amin Baig; Maciej Banach; Mehmet Firat Baran; Mainak Bardhan; Hiba Jawdat Barqawiil; Amadou Barrow

Burden of disease; Disease burden; Cannabis; Opioid use disorder; Global health; Public health; Disease; Medicine; Environmental health; Prevalence; Opioid; Drug; Psychiatry

2026-01-16https://doi.org/10.1038/s41591-025-04137-0Nature Medicine 20261Obesity rise plateaus in developed nations and accelerates in developing nationsand lacks a granular and systematic analysis of its dynamics. We used 4,050 population-based studies with measured height and weight data on 232 million participants to assess the worldwide dynamics of obesity from 1980 to 2024. The rise in obesity decelerated in school-aged children and adolescents throughout the 1990s in many high-income countries, and subsequently plateaued in most at age-standardized prevalences spanning 20 percentage points, from 3-4% for girls in Japan, Denmark and France to 23% for boys in the USA. There were indications of a small decline in obesity in children and adolescents in some high-income western countries (for example, Italy, Portugal and France) since the 2000s. Similar trends were seen in some countries in Central and Eastern Europe. In adults, the rise in obesity slowed down in high-income western countries about a decade after children, followed by a plateau or possibly a small reversal of the rise in some countries (for example, Spain). In most low-income and middle-income countries, the annual absolute change in prevalence has remained stable or increased over time, even though prevalence has surpassed that of high-income countries. These highly varied dynamics suggest that the social, economic and technological trends that influence the availability, affordability and use of different foods may have helped control the rise in obesity in high-income countries, but require policy interventions in low-income and middle-income countries.Bin Zhou; Nowell H Phelps; Agnese Galeazzi; Olivia N. O’Driscoll; James E. Bennett; Lakshya Jain; Yse D'Ailhaud De Brisis; Ana Barradas‐Pires; Fulvio Deo; Gretchen A. Stevens; Vasilis Kontis; Christopher J. Paciorek; Rodrigo M. Carrillo-Larco; Anu Mishra; 范晔峰; Andrea Rodriguez‐Martinez; Vishwa Nath; A. Rayner; Annalise Zouein; Natalie Evans; Jennifer L. Baker; Günther Fink; Maroje Sorić; Carlos A. Aguilar-Salinas; Ranjit Mohan Anjana; Zulfiqar A. Bhutta; Pascal Bovet; Goodarz Danaei; Kairat Davletov; Shubash Ganapathy; Edward W. Gregg; Nayu Ikeda; André Pascal Kengne; Young‐Ho Khang; K Khunti; Tiina Laatikainen; Avula Laxmaiah; Lee‐Ling Lim; H Y Lin; J Mbanya; J Jaime Miranda; Anja Schienkiewitz; Sylvain Sebert; Namuna Shrestha; Yi Song; Luis Adrián Soto-Mota; Gregor Starc; L L Wang; Novie O. Younger-Coleman; Francesco Zaccardi; Julie Aarestrup; Leandra Abarca-Gómez; Mohsen Abbasi‐Kangevari; Ziad Abdeen; Shynar Abdrakhmanova; Suhaila Abdul Ghaffar; Hanan F. Abdul Rahim; Zulfiya Abdurahmnova; Niveen M. Abu-Rmeileh; Jamila Abubakar Garba; Benjamín Acosta-Cázares; Ishag Adam; Marzena Adamczyk; Robert J. Adams; Seth Adu-Afarwuah; Wichai Aekplakorn; Tin Afifah; Kaosar Afsana; Shoaib Afzal; Imelda A. Agdeppa; Javad Aghazadeh-Attari; Åsa Ågren; Hassan Aguenaou; Charles Agyemang; Mohamad Hasnan Ahmad; Noor Ani Ahmad; Ali Ahmadi; Naser Ahmadi; Nastaran Ahmadi; Imran Ahmed; Soheir H. Ahmed; Wolfgang Ahrens; Gulmira Aitmurzaeva; Kamel Ajlouni; Дилором Ахмедова; Nilufar Akhmedova; Nasser Al-Daghri; Sarah F. Al-Hamli; Hazzaa M. Al-Hazzaa; Halima Al-Hinai; Jawad A. Al-Lawati; Rajaa Al‐Raddadi; Islam K. Al-Shami; Deena Al Asfoor; Huda M. Al Hourani; Nawal M. Al Qaoud; Monira Alarouj; Fadia AlBuhairan; Shahla AlDhukair; M. Aldwairji

Obesity; Developing country; Developed country; Psychological intervention; Global health; Plateau (mathematics); Development economics; Demography; Geography; Environmental health; Medicine; Nutrition transition

2026-05-13https://doi.org/10.1038/s41586-026-10383-0Nature 20261Automated machine learning achieves accurate water quality prediction with reduced parameter requirementsAccurate water quality assessment is critical for environmental monitoring and public health. Conventional Water Quality Index (WQI) computation methods, however, often rely on numerous parameters and labor-intensive processes, thus limiting their practicality for rapid assessments. While Machine Learning (ML) offers promising alternatives, the development of high-performing models typically demands extensive expertise and computational resources. This study addresses the latter gap by leveraging Automated Machine Learning (AutoML), specifically the AutoGluon platform, to predict WQI from a reduced set of readily available water quality parameters. Our objectives were to (i) evaluate the predictive performance of AutoML with reduced inputs, (ii) assess model interpretability via feature importance, and (iii) propose an automated framework for efficient water quality monitoring. This study analyzed a 36-year dataset from Taiwan's national river water quality monitoring network, focusing on four parameters: electrical conductivity (EC), suspended solids (SS), water temperature (WT), and pH. A fully automated pipeline handled model selection, hyperparameter tuning, and ensemble construction by systematically testing multiple algorithm families and stacking strategies to determine the optimal setup for each parameter. This eliminated manual intervention and delivered reproducible, data-driven results that matched the distinct spatiotemporal patterns in the long-term records. Among the evaluated algorithms, ensemble-based tree models (CatBoost, Random Forest, and XGBoost) demonstrated superior performance, achieving a mean [Formula: see text] of 0.76 and low predictive errors. Feature importance analysis identified EC as the most influential predictor. Such results highlight the feasibility of reducing the number of input parameters without compromising prediction accuracy, thereby enabling faster and cost-effective water quality assessments.Deivid Campos; Viviane Galvão; Matheus Lopes de Rezende; Allan S. Braga; Matteo Bodini; Uilson R. V. Aires; Roland Yonaba; Leonardo Goliatt

Interpretability; Random forest; Hyperparameter; Pipeline (software); Predictive modelling; Water quality; Ensemble learning; Decision tree; Set (abstract data type); Machine learning; Computer science; Artificial intelligence; Data mining; Feature (linguistics); Quality (philosophy); Ensemble forecasting; Pipeline transport; Tree (set theory); Feature engineering; Computation

2026-01-07https://doi.org/10.1038/s41598-025-34448-8Scientific Reports 20261Statin Therapy Independently Reduces Mortality and Liver Complications in Patients With Cirrhosis: An Updated Systematic Review and Meta‐AnalysisBACKGROUND: The role of statins in cirrhosis remains controversial. Historically restricted due to safety concerns, emerging evidence highlights potential pleiotropic benefits, though effects on mortality and decompensation remain uncertain. AIMS: To evaluate the effects of statin therapy on all-cause mortality, hepatic decompensation, hepatic venous pressure gradient (HVPG), and hepatocellular carcinoma (HCC) in cirrhosis. METHODS: We systematically searched major databases until July 2025 for randomised controlled trials (RCTs) and observational studies comparing statin therapy versus non-use in cirrhosis. Random-effects meta-analyses were performed. RESULTS: The meta-analysis included 25 studies (9 RCTs, 16 observational) with 81,992 patients. Statins reduced all-cause mortality in the overall analysis (unadjusted odds ratio 0.59; 95% CI: 0.48-0.71) and in RCTs (odds ratio 0.45; 95% CI 0.25-0.82), supported by a significant HVPG reduction. Conversely, statins reduced hepatic decompensation in the overall analysis (unadjusted odds ratio 0.56; 95% CI: 0.47-0.66) but not in RCTs (odds ratio 0.75; 95% CI: 0.52-1.09). Observational data indicated a protective association for HCC (adjusted hazard ratio 0.61; 95% CI: 0.46-0.82), and no RCT reported this outcome. CONCLUSIONS: Statin therapy is associated with improved survival in cirrhosis, supported mechanistically by reductions in portal pressure. Observational evidence suggests benefits for decompensation and HCC, though these remain uncertain due to residual confounding. Large-scale, long-term RCTs are needed to clarify the role of statins as disease-modifying therapy in cirrhosis.Bernardo de Faria Moraes; Gustavo André Pedral Diniz Leite; Igor Boechat Silveira; Gabriel André Pedral Diniz Leite; Maria Luisa Motta Fonseca; LEONARDO CORREA SÜFFERT; Luisa Medeiros Visentini; Luis Pedro Possapp Beis; Guilherme Grossi Lopes Cançado

Observational study; Statin; Decompensation; MEDLINE; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Randomized controlled trial; Medicine; Intensive care medicine; Internal medicine; Residual risk; Pharmacotherapy; Systematic review

2026-01-10https://doi.org/10.1111/apt.70526Alimentary Pharmacology & Therapeutics 20261Transforming jet flavour tagging at ATLASJet flavour tagging enables the identification of jets originating from heavy-flavour quarks in proton-proton collisions at the Large Hadron Collider, playing a critical role in its physics programmes. This paper presents GN2, a transformer-based flavour tagging algorithm deployed by the ATLAS Collaboration that represents a different methodology compared to previous approaches. Designed to classify jets based on the flavour of their constituent particles, GN2 processes low-level tracking information in an end-to-end architecture and incorporates physics-informed auxiliary training objectives to enhance both interpretability and performance. Its performance is validated in both simulation and collision data. The measured c-jet (light-jet) rejection in data is improved by a factor of 3.5 (1.8) for a 70% b-jet tagging efficiency, compared to the previous algorithm. GN2 provides substantial benefits for physics analyses involving heavy-flavour jets, such as measurements of Higgs boson pair production and the couplings of bottom and charm quarks to the Higgs boson, and demonstrates the impact of advanced machine learning methods in experimental particle physics.G. Aad; E. Aakvaag; B. Abbott; Sara Abdelhameed; Karin Abeling; N. J. Abicht; S. H. Abidi; Mohammed Aboelela; A. Aboulhorma; H. Abramowicz; Y. Abulaiti; B. S. Acharya; Alexander Ackermann; C. Adam Bourdarios; L. Adamczyk; S. V. Addepalli; M. J. Addison; J. Adelman; A. Adiguzel; T. Adye; A. A. Affolder; Y. Afik; M. N. Agaras; A. Aggarwal; C. Agheorghiesei; F. Ahmadov; S. Ahuja; X. Ai; G. Aielli; A. Aikot; M. Ait Tamlihat; B. Aitbenchikh; M. Akbiyik; T. P. A. Åkesson; A. V. Akimov; D. Akiyama; N. N. Akolkar; S. Aktas; G. L. Alberghi; Jeffrey Ryan Albert; Una Helena Alberti; P Albicocco; G. L. Albouy; S. Alderweireldt; Z. L. Alegria; Martin Aleksa; I. N. Aleksandrov; Călin Alexa; T. Alexopoulos; F. Alfonsi; M. Algren; M. Alhroob; B. Ali; H. M. J. Ali; S. Ali; S. W. Alibocus; M. Aliev; G. Alimonti; W. Alkakhi; C. Allaire; B. M. M. Allbrooke; J. S. Allen; Julia Frances Allen; P. P. Allport; A. Aloisio; F. Alonso; C. Alpigiani; Z. M. K. Alsolami; A. Alvarez Fernandez; M. Alves Cardoso; M. G. Alviggi; M. Aly; Y. Amaral Coutinho; A. Ambler; C. Amelung; M. Amerl; C. G. Ames; T. Amezza; D. Amidei; Baktash Amini; K. Amirie; Artem Amirkhanov; S. P. Amor Dos Santos; K. R. Amos; D. Amperiadou; S. An; C. Anastopoulos; T. Andeen; J. K. Anders; A. C. Anderson; A. Andreazza; S. Angelidakis; A. Angerami; A. V. Anisenkov; A. Annovi; C. Antel; E. Antipov; M. Antonelli; F. Anulli; Mayumi Aoki

Atlas (anatomy); Flavour; Higgs boson; Large Hadron Collider; Interpretability; Quark; Jet (fluid); Collision; Particle physics; Physics; Nuclear physics; ATLAS experiment; Hadron; Physics beyond the Standard Model; Phenomenology (philosophy); Tracking (education)

2026-01-14https://doi.org/10.1038/s41467-025-65059-6Nature Communications 202613D-printed resins intended for long-term restoration vs. conventionally used materials: A systematic review and network meta-analysis of in vitro studiesOBJECTIVES: This systematic review with network meta-analysis (NMA) evaluated whether three-dimensional (3D) printed resin-based composites (RBCs) intended for long-term dental restorations perform similarly or superiorly to conventional restorative materials. DATA SOURCES: The review followed the PRISMA extension for NMA. Six electronic databases were searched up to November 2025. STUDY SELECTION: In vitro studies assessing at least one commercially available 3D-printed RBC for long-term dental restorations and at least one conventional restorative material were eligible. Methodological quality was assessed using the RoBDEMAT tool, and data were synthesized using Bayesian NMA. RESULTS: From 2299 records, 50 studies met the inclusion criteria, of which 40 were included in the meta-analyses. Across mechanical, physical, reproducibility, and optical outcomes, 3D-printed RBCs generally performed similarly to or worse than most conventional materials. However, they demonstrated superior marginal and internal fit compared with glass ceramics, polymer-infiltrated ceramic networks, and polymeric restoratives, except when compared with direct RBCs, indicating enhanced dimensional accuracy. CONCLUSIONS: Although 3D printing achieved superior trueness and internal/marginal fit relative to most conventional restorative materials, the inferior mechanical performance, suboptimal microstructural characteristics, and limited optical stability of 3D-printed resins underscore the need for improvements in material formulation, post-curing strategies, and finishing and polishing protocols. CLINICAL SIGNIFICANCE: At present, 3D-printed resins for long-term single-unit restorations do not yet match the overall performance of established conventional restorative systems.Eddy Jhonny Alvarez Lalvay; Fabíola Galbiatti de Carvalho; Antoni Raupp da Silva; Francisco Amaro Cruz Morganti; Fabrício Mezzomo Collares; Eliseu Aldrighi Münchow

Inlay; Materials testing; Dental restoration; Acrylic resin; Synthetic resin; Materials science; Dentistry

2026-01-31https://doi.org/10.1016/j.jdent.2026.106531Journal of Dentistry 20261Thirty years of the Family Health Strategy in the Brazilian Unified National Health System: milestones, advances, setbacks and challengesThis essay examines the trajectory and persistent challenges faced by Brazil's Family Health Strategy (FHS), stemming from concerns regarding the prospects for the full implementation this territory-based community-oriented approach to the delivery of primary health care within the Brazilian Unified National Health System. We look at the development of the strategy and provide a critical overview of the main institutional milestones over the last 30 years, focusing on the following: federal funding associated with the process of the municipalization of care; the expansion of multidisciplinarity in the work of health professionals in basic health units (BHU) and the local community; improvements in quality associated with the evaluation of team structure and work processes and performance-based funding; and emergency medical staffing in underserved areas and professional training. We outline how the expansion of FHS coverage and the adoption of practices centered on individuals, families and communities has impacted population health and access to care. Setbacks between 2016 and 2022 are critically addressed, including the undermining of the multidisciplinary community-based approach and threats to universality and comprehensiveness. We then go on to discuss the reprioritization of the FHS by the Federal Government in 2023. Data from the 2024 national BHU Census are used to illustrate the current status of the FHS. Challenges to implementing effective change in the care model and achieving universal FHS coverage include the following: ensuring adequate funding, employment stability, professional training and interprofessional collaboration; addressing the risks of commodification in primary health care (PHC); improving coordination of care and the strengthening the role of PHC in patient access management; and reducing geographical, social and racial inequalities in access to care.Lígia Giovanella; Maria Helena Magalhães de Mendonça; Estela Márcia Saraiva Campos; Ana Luíza Queiroz Vilasbôas; Rosana Aquino; Luiz Augusto Facchini

Staffing; Multidisciplinary approach; Health care; Government (linguistics); Population; Health policy; Work (physics); Public health; Nursing; Economic growth; Medicine; Public relations; Political science; International health; Family health; Program evaluation; Population health

2026-01-01https://doi.org/10.1590/0102-311xen206025Cadernos de Saúde Pública 20261Pulsed field vs thermal ablation for atrial fibrillation: A Bayesian meta-analysisFlávia Queiroga; André Rivera; Letizia Consoli; Arthur M. Albuquerque; Ivo Queiroz; Maria Antônia Costa Cruz Akabane; Wellgner Fernandes Oliveira Amador; Nelson Barrera; Juliana Giorgi; Guilherme Dagostin de Carvalho; Sanghamitra Mohanty; Hugh Calkins; Moussa Mansour; Andrea Natale; Vivek Y. Reddy

Ablation; Catheter ablation; Thermal ablation; Atrial fibrillation; Bayesian probability; Observational study; SIGNAL (programming language); Medicine; Cardiology; Internal medicine; Cardiac Ablation; Field (mathematics); Biomedical engineering; Catheter; Thermal

2026-02-25https://doi.org/10.1016/j.hrthm.2026.02.028Heart Rhythm 20261Experimental Models of Acute Lung Injury to Study Inflammation and Pathophysiology: A Narrative ReviewAcute lung injury (ALI) is characterized by acute respiratory insufficiency, including tachypnea, cyanosis refractory to oxygen, decreased lung compliance, and diffuse alveolar infiltrates, which is a condition associated with high morbidity and mortality that usually results in the development of multiple organ dysfunction. Acute lung injury in humans is histopathologically characterized by neutrophilic alveolitis, injury of the alveolar epithelium and endothelium, hyaline membrane formation, and microvascular thrombi. Different animal models of experimental lung injury have been used to investigate mechanisms of lung injury, such as LPS-induced ALI, hyperoxia-induced ALI, and ventilator-induced lung injury (VILI). Here we will show selected preclinical mice models used as proof of concept to test new drugs in vivo with anti-inflammatory properties, discussing their particularities and clarifying the context of use.Akinori Cardozo Nagato; Pedro Alves Machado-Júnior; Samuel Santos Valenca; Remo Castro Russo; Frank Silva Bezerra

Lung; Diffuse alveolar damage; Context (archaeology); Narrative review; Inflammation; Hyaline; Pulmonary edema; Refractory (planetary science); Medicine; Pathology; Respiratory system; Review article

2026-01-02https://doi.org/10.3390/antiox15010063Antioxidants 20261One health approach to Balantioides coli: Molecular and metabarcoding evidence of zoonotic transmissionBalantioides coli is a neglected zoonotic protozoan, with pigs recognized as its main reservoirs. In tropical countries such as Brazil, information on balantidiasis in occupationally exposed human populations remains limited. In this context, this study investigated the occurrence of B. coli and other intestinal parasites in pig farmers, their families, and pigs from the same farms, while also exploring associations with sanitary conditions and the gut microbiota. Fecal samples from 47 humans and 15 pigs from family-owned and industrial farms in Rio de Janeiro and Minas Gerais, Brazil, were analyzed. General and sanitary information was obtained through structured questionnaires. Samples were examined by microscopy, and B. coli was identified by PCR targeting ITS1-5.8S-ITS2, followed by Sanger sequencing. The gut microbiota was characterized using 18S and 16S rRNA (V3/V4) molecular markers for metabarcoding. Among the 47 participants, seven (14.9%) tested positive for B. coli nucleotide sequences in their fecal material, with most of them (71.4%) being adult males directly involved in pig handling. Phylogenetic analysis revealed genetic variants A0, B0, and atypical strains shared between humans and pigs from the same farm. Eukaryotic parasites (B. coli, Blastocystis spp., Entamoeba spp.) and prokaryotic groups (Firmicutes, Bacteroidota, and potentially pathogenic bacteria) were also shared across hosts, and two human-pig pairs (H31-129F and H70-565F) exhibited highly similar microbial profiles. This study provides the first molecular evidence of B. coli in pig farmers in Brazil, reinforcing the epidemiological role of pigs in zoonotic transmission. These findings highlight the need for improved sanitation, consistent use of personal protective equipment, and continuous molecular surveillance under a One Health perspective to minimize transmission of this parasite.Camila Souza Carvalho Class; Pedro Mendes de Souza; Renan de Souza Ferreira; Ingrid da Silva Reis; Laís Lisboa Corrêa; Breno Torres da Silva; Gabriella Ribeiro Vaz da Costa; Fabiana Batalha Knackfuss; Roberto Júnio Pedroso Dias; Alynne Da Silva Barbosa

Feces; Blastocystis; Zoonosis; Phylogenetic tree; Molecular epidemiology; Transmission (telecommunications); Parasitology; Polymerase chain reaction; Sanger sequencing; Phylogenetics; Biology; Microbiology; Genotype; Zoology; Escherichia coli; Medical microbiology; Veterinary medicine; 16S ribosomal RNA; Genetics

2026-01-05https://doi.org/10.1371/journal.pone.0338487PLoS ONE 20261A comparative study of ensemble and non-ensemble machine learning methods for predicting river pollution indexAccurate prediction of river water quality is fundamental to environmental sustainability and public health, particularly amid increasing freshwater scarcity. This study develops a robust Machine Learning (ML) framework to forecast the River Pollution Index (RPI) using a comprehensive 36-year national dataset from Taiwan’s Environmental Protection Administration, covering over 500 monitoring stations. We conducted a systematic comparison of ensemble methods (CatBoost, XGBoost, NGBoost) and non-ensemble benchmarks (SVM, ElasticNet, and 1D CNN). Hyperparameters were optimized via Bayesian optimization, and statistical significance was ensured by evaluating model stabilityusing a suite of complementary indicators (RMSE, MAE, R 2 , A10 index) across 30 independent experimental runs. The results demonstrated the consistent superiority of ensemble models over non-ensemble counterparts. Among them, CatBoost achieved the highest accuracy and stability (RMSE ≈ 0.85, MAE ≈ 0.61, R 2 = 0.78), reducing prediction error by approximately 20% relative to SVM and ElasticNet. These findings highlight the capacity of ensemble learning techniques to capture complex, non-linear interactions inherent in water quality data. The study makes two principal contributions: (1) the systematic implementation, optimization, and comparison of ensemble and non-ensemble ML models for river pollution prediction on a long-term national dataset; and (2) the identification of ensemble-based methods, particularly CatBoost, as robust and data-driven tools to enhance RPI forecasting and to support informed decision-making in sustainable water resource management. • Evaluated ML models on a 36-year nationwide river pollution dataset from Taiwan. • Compared ensemble (CatBoost/XGBoost/NGBoost) vs non-ensemble methods (SVM/CNN). • CatBoost achieved superior stability and accuracy (RMSE ≈ 0.85, R 2 = 0.78). • Ensemble models reduced prediction error by ∼ 20% versus non-ensemble benchmarks. • Bayesian optimization and 30 runs validated model robustness and reliability.Luisa S.R. Nogueira; Mariana A.S. de Carvalho; Berilo de O. Santos; Roland Yonaba; Apoorva Bamal; Md Galal Uddin; Matteo Bodini; Leonardo Goliatt

Ensemble learning; Ensemble forecasting; Support vector machine; Water quality; Hyperparameter; Water resources; Stability (learning theory); Bayesian probability; Index (typography); Machine learning; Computer science; Artificial intelligence; Data mining; Predictive modelling; Pollution; Ranking (information retrieval); Environmental pollution; Resource (disambiguation); Quality (philosophy); Random forest; Multivariate statistics; Sustainability; Environmental science

2026-01-21https://doi.org/10.1016/j.ecoinf.2026.103617Ecological Informatics 20261Enhanced Control of Leucoptera coffeella on Coffee Leaves Using Cyantraniliprole-Hybrid Polymeric MembranesHigh Resolution Image Download MS PowerPoint Slide Leucoptera coffeella is a significant lepidopteran pest of coffee ( Coffea spp.) crops, capable of causing yield losses of up to 80%. While chemical control with synthetic insecticides remains the predominant strategy, challenges such as pest resistance and environmental contamination highlight the urgent need for more sustainable alternatives. Hybrid polymeric membranes, formulated from Laponite RD clay, sodium alginate, and the insecticide cyantraniliprole, were developed in this study to serve as protective coatings for coffee leaves. Their successful synthesis and the effective integration and interaction of cyantraniliprole within the hybrid matrix were corroborated by proper characterization, including powder X-ray diffraction, Fourier-transform infrared spectroscopy with attenuated total reflectance, thermogravimetric analysis coupled with differential scanning calorimetry, and scanning electron microscopy with energy-dispersive spectroscopy. Bioassay experiments in a greenhouse using seedlings of Catuaí vermelho, a coffee variety of the Coffea arabica species, were conducted in a randomized block design with eight treatments and four replicates. Larval mortality and egg deposition were assessed and statistically analyzed using the Scott-Knott test ( p < 0.05). The hybrid membranes significantly increased larval mortality and reduced oviposition compared to both control and commercial insecticide treatments. These findings underscore the potential of these membranes as an eco-friendly alternative for integrated pest management in coffee cultivation, offering advantages such as improved adhesion, sustained release, and reduced pesticide usage.Caroline Nunes dos Reis; Lorena Alves de Melo Bessa; Maria Gabrielle Silva; Thaissa Moreira Santos; Keyller Bastos Borges; E. Trindade Alves; Júlio César José da Silva; Gustavo Franco de Castro; Carlos Gustavo da Cruz; F. L. FERNANDES; Jairo Tronto

PEST analysis; Integrated pest management; Pest control; Pesticide; Membrane; Thermogravimetric analysis; Biology; Randomized block design; Toxicology; Bioassay; Chemistry; Yield (engineering)

2026-01-23https://doi.org/10.1021/acsomega.5c11821ACS Omega 20261Body composition and physical fitness in transgender versus cisgender individuals: a systematic review with meta-analysisOBJECTIVE: To compare body composition and physical fitness between transgender and cisgender individuals. DESIGN: Systematic review with meta-analysis. DATA SOURCES: PubMed, Web of Science, Embase and SportDiscus. ELIGIBILITY CRITERIA: Inclusion criteria comprised studies of transgender individuals comparing body composition or physical fitness pre-to-post gender-affirming hormone therapy (GAHT) or versus cisgender controls. RESULTS: 52 studies (n=6485) were included. Transgender women had similar relative fat mass (standardised mean difference (SMD) -0.33, 95% CI -0.72 to 0.05, Grading of Recommendations Assessment, Development and Evaluation (GRADE): very low), relative lean mass (SMD 0.19, 95% CI -0.14 to 0.53, GRADE: low), upper-body strength (SMD 0.54, 95% CI -0.95 to 2.02, GRADE: very low), lower-body strength (SMD 0.05, 95% CI -1.31 to 1.40, GRADE: very low) and maximal oxygen consumption (SMD -0.28, 95% CI -0.81 to 0.25, GRADE: very low) in comparison to cisgender women. Transgender men exhibited higher relative fat mass (SMD 0.96, 95% CI 0.28 to 1.64, GRADE: moderate), lower relative lean mass (SMD -6.42, 95% CI -12.26 to -0.58, GRADE: moderate) and lower upper-body strength (SMD -1.46, 95% CI -2.52 to -0.40, GRADE: moderate) than cisgender men. In transgender women, GAHT was associated with increased fat mass and reduced lean mass and upper-body strength over 1-3 years. Transgender men demonstrated reduced fat mass and increased lean mass and strength following GAHT. CONCLUSION: While transgender women exhibited higher lean mass than cisgender women, their physical fitness was comparable. Current evidence is mostly low certainty and has heterogenous quality but does not support theories of inherent athletic advantages for transgender women over cisgender. PROSPERO REGISTRATION NUMBER: CRD42024562210.Sofia Mendes Sieczkowska; Bruna Caruso Mazzolani; Danilo Reis Coimbra; Igor Longobardi; Andresa Rossilho Casale; José Davi Fajardo Villela Martins P da Hora; Hamilton Roschel; Bruno Gualano

Transgender; Physical fitness; Composition (language); Physical activity; MEDLINE; Gender identity; Gerontology; Psychology; Medicine; Clinical psychology; Physical therapy

2026-02-01https://doi.org/10.1136/bjsports-2025-110239British Journal of Sports Medicine 20261Second-Generation Aldosterone Synthase Inhibitors for HypertensionBACKGROUND: Second-generation aldosterone-synthase inhibitors (ASIs) may offer a novel treatment for hypertension. OBJECTIVES: The objective of the study was to assess the efficacy and safety of ASIs in this clinical setting. METHODS: We searched major databases for randomized controlled trials (RCTs) assessing ASIs (baxdrostat, lorundrostat, and vicadrostat) in patients with hypertension. For efficacy outcomes, mean differences (MD) with 95% credible intervals (CrIs) were estimated using a Bayesian random-effects model. For adverse events, OR with 95% CrI were estimated using a Bayesian binomial-normal hierarchical model. The protocol was registered in Prospective Register of Systematic Reviews (CRD420251132306). RESULTS: 0.1). In subgroup analysis, the probability of achieving a clinically meaningful reduction in SBP (MD < -5 mm Hg) was 87.5% with baxdrostat and 94.3% with lorundrostat. CONCLUSIONS: Second-generation ASIs had a high likelihood of a clinically significant reduction in SBP compared with placebo. However, hyperkalemia, hyponatremia, and hypotension were more frequent with ASIs.Flávia Queiroga; Beatriz Barbosa Cruz Soares Araújo; André Rivera; Letizia Consoli; Aditi Ujjawal; Ensieh Sadat Mansouri; Maria Antônia Costa Cruz Akabane; Nelson I. Barrera; Ana Ramos; Asad Iqbal; Marcelo Braga; Anna Krawisz; Paula Dibo; Deepak L. Bhatt

Aldosterone; Aldosterone synthase; Blood pressure; Enzyme inhibitor; Renin–angiotensin system; Enzyme; Internal medicine; Medicine; Endocrinology; Pharmacology; Chemistry

2026-02-27https://doi.org/10.1016/j.jacadv.2026.102621JACC Advances 20261Epidemiology of cerebral palsy in Brazil through the lens of the International Classification of Functioning, Disability and Health frameworkAIM: To establish an overall description of people with cerebral palsy (CP) in Brazil, including the epidemiology, clinical features, functioning, and access to rehabilitation and equipment, through the lens of the International Classification of Functioning, Disability and Health (ICF) framework, using preliminary data from the Brazilian Cerebral Palsy Register (BrCPR). METHOD: Data were extracted from the ongoing BrCPR for individuals with CP aged 0 to 100 years. The information collected included aetiological risk factors and, from the ICF, personal and health-related factors, environmental factors, body functions and structures, activity, and participation. RESULTS: A total of 1098 participants were included (median age 9 years [interquartile range 5-15 years]; 57.6% male). Most brain injuries occurred pre- or perinatally (68.1%), with preterm birth (44.8%) and perinatal asphyxia (51.1%) being common risk factors. Postneonatal CP (>28 days) was often infection-related (23.0%). One-third of all children were diagnosed before 6 months of age. Bilateral spastic CP predominated (59.4%), and 54.9% were classified in Gross Motor Function Classification System levels IV or V. Co-occurring conditions included epilepsy (57.5%), hip dislocation (31.0%), and cognitive impairment (55.3%). Severe activity limitations were reported, for example dressing (58.9%). Considering participation, 10.0% never attended school. Among environmental barriers, 67.7% lacked home adaptations, 14.0% received no rehabilitation, and 44.7% lacked necessary assistive devices. INTERPRETATION: The BrCPR highlights substantial unmet needs among individuals with CP in Brazil.Hércules Ribeiro Leite; Luana Cristina da Silva; Elton Duarte Dantas Magalhães; Israt Jahan; Nadia Badawi; Gulam Khandaker; Maysa Ferreira Martins Ribeiro; Juliana de Alcântara Moreira Pereira; Luma Sthephanine Viana Roque da Silva; María de las Mercedes Ruiz Brünner; Paula Silva de Carvalho Chagas

Cerebral palsy; Epidemiology; International Classification of Functioning, Disability and Health; MEDLINE; Lens (geology); Through-the-lens metering; Medicine; Physical medicine and rehabilitation; Optometry; Physical therapy; Gerontology

2026-03-12https://doi.org/10.1111/dmcn.70222Developmental Medicine & Child Neurology 20261Operational early-warning forecasts of aquaculture water quality: Interpretable ML for TDS under walk-forward validationAquaculture water quality exhibits time-dependent dynamics, making accurate short-term forecasting essential for proactive farm management. This study presents a leakage-safe and interpretable machine-learning framework for forecasting total dissolved solids (TDS) from high-frequency aquaculture sensor time series. The proposed approach integrates lag-based feature engineering with an expanding-window walk-forward validation protocol (19 folds) to ensure realistic time-forward evaluation and to avoid information leakage. Under a leakage-safe lag-only specification that excludes redundant conductivity predictors, tree-based ensemble learning emerged as the most robust solution. XGBoost achieved the highest forecasting accuracy, yielding a mean MAE of 0.314 ± 0.482 mg/L and RMSE of 1.596 ± 4.206 mg/L across walk-forward folds. Residual diagnostics based on ACF/PACF and Ljung–Box testing indicated no significant remaining autocorrelation, confirming that predictive skill is not driven by residual serial dependence. SHAP-based interpretation revealed that TDS dynamics are primarily governed by ionic-strength-related signals, whereas temperature and pH contribute marginally. By combining leakage-safe validation, ensemble forecasting, and explainable inference, this work advances an operational early-warning and decision-support framework for sustainable aquaculture water-quality management.Md. Abdullah Al Mamun Hridoy; Matteo Bodini; Munshaibur Rahman Mahin; Petra Schneider; Paolo Pastorino; Chiara Bordin; Md. Abdullah Al Mamun; Leonardo Goliatt

Aquaculture; Model validation; Water quality; Hydrology (agriculture); Water supply; Environmental science

2026-05-03https://doi.org/10.1016/j.ecoinf.2026.103804Ecological Informatics 20261Multifaceted maleimide scaffolds in focus: from synthesis to photophysical applicationsmono- or dihalogenation of maleic anhydride, these approaches offer limited structural diversity and often require multiple steps. In this work, we highlight recent developments in non-conventional synthetic strategies for accessing 3- and 3,4-substituted maleimides. Special emphasis is placed on methodologies based on transition metal catalysis and organocatalysis, which enable the direct introduction of substituents onto the maleimide core. These advances expand the diversity of accessible structures, facilitating new applications and reactivity profiles. In selected cases, we also discuss how these synthetic routes have led to the development of maleimide derivatives with notable photophysical properties, particularly fluorescence, which may serve in future applications. Overall, this tutorial review provides a comprehensive synthetic perspective on recent advances in the field, aiming to support further innovation in maleimide chemistry.Marcelo H. R. Carvalho; Gabriel M. F. Batista; Pedro P. de Castro; B. A. D. Neto; Giovanni W. Amarante

Maleimide; Organic synthesis; Functional diversity; Catalysis; Nanotechnology; Combinatorial chemistry; Chemistry; Biochemical engineering

2026-01-01https://doi.org/10.1039/d5cs00880hChemical Society Reviews 20261Metabolic reprogramming enhances oxidative stress resistance in differentiating cardiomyocytesCardiomyocyte differentiation is a complex process involving significant metabolic remodeling, but its impact on cellular redox state and cell damage remains poorly understood. Using metabolomics, biophysical, and biochemical approaches, we characterized, in vitro, the metabolic shift of differentiating cardiomyocytes and its implications for oxidative damage. We found that differentiating cardiomyocytes undergo a broad metabolic reprogramming from a glycolytic to an oxidative state, marked by increased activity in key pathways, including malate-aspartate shuttle, glutathione metabolism, and tricarboxylic acid cycle. This metabolic transition was associated with mitochondrial enlargement and increased reactive oxygen species (ROS) production. Intriguingly, despite ROS increase, differentiated cells maintained similar levels of DNA damage as cardiomyoblasts and were more resistant to a H₂O₂ challenge. Our findings suggest that metabolic adaptations during cardiomyocyte differentiation enhance their capacity to mitigate oxidative stress damage, providing an adaptive avenue that enables cardiomyocyte survival upon exposure to an oxygen-rich environment.Lara Basseres Novais; Beatriz Rodrigues; Flávia Oliveira Borges Pereira; Alan Gonçalves Amaral; Sofya Castilho Lapa; Lucas Lopes Maldonado; Pedro Víctor-Carvalho; Isabela Aparecida Moretto; Hans Rolando Zamora-Obando; Mariana Conceição da Silva; Ana Paula Samogim; Ingridi Rafaela de Brito; Maria das Graças de Souza Carvalho; Antonio Thiago Pereira Campos; Michelle Bueno de Moura Pereira Antunes; Carlos Lenz Cesar; Hernandes F. Carvalho; Ana Valéria Colnaghi Simionato; André A. de Thomaz; Aline Mara dos Santos

Oxidative stress; Oxidative phosphorylation; Reactive oxygen species; Glycolysis; Reprogramming; Glutathione; Mitochondrion; Citric acid cycle; Cell biology; Biochemistry; Biology; Chemistry; Cellular differentiation; Metabolic pathway; Cell; DNA damage; Metabolism; Myocyte

2026-01-20https://doi.org/10.1038/s41598-026-35263-5Scientific Reports 20261Mental illness, mental health, and mental well-beingMental health is sometimes understood as merely the absence of mental illness and sometimes more expansively as inclusive of a broader and more complete mental well-being. We present conceptual, empirical, and causal evidence for a distinction between the absence of mental illness and positive mental well-being. We discuss the implications for assessment, national tracking, research, policy, and mental healthcare. We argue for a greater clinical, policy, and public health attentiveness to positive mental well-being, to supplement work already being done on the treatment and prevention of mental illness.Tyler J. VanderWeele; Byron R. Johnson; Matt Bradshaw; David Goodman; Laura D. Kubzansky; Tim Lomas; Alexander Moreira-Almeida; Chukwuemeka N. Okafor; Suzanne T Ouyang; Vikram Patel

Mental health; Mental illness; Mental health law; Middle Eastern Mental Health Issues & Syndromes; Psychological intervention; Mental health care; Psychology; Psychiatry

2026-02-14https://doi.org/10.1038/s44184-026-00193-7npj Mental Health Research 20261Trichosporonaceae as (Re-)Emerging Pathogens: A Warning to the Medical CommunityBackground: The Trichosporonaceae family includes genera such as Trichosporon, Apiotrichum, and Cutaneotrichosporon, which are components of the human microbiota but may cause infections under conditions such as immunosuppression, prolonged hospitalization, invasive procedures, and broad-spectrum antimicrobial use. Objectives: This study aimed to describe the clinical and epidemiological characteristics of hospitalized and outpatient individuals with positive cultures for Trichosporonaceae species in Juiz de Fora, Minas Gerais, Brazil, and to correlate these findings with antifungal susceptibility profiles. Methods: Clinical isolates collected between 2020 and 2023 were identified using the Vitek 2® system, and antifungal susceptibility was assessed by disk diffusion. Clinical and epidemiological data were obtained from electronic health records. Results: Among 40 isolates, Trichosporon asahii predominated (92.5%). Most cases involved hospitalized individuals (83.8%), mainly from intensive care units (81.8%). Respiratory infections and acute renal failure were the most common reasons for admission. The mean hospital stay was 34.8 days, and overall mortality reached 51.6%. Most individuals were male (77.5%) and older than 61 years (57.5%). Urine was the most frequent specimen (52.5%), and invasive infections predominated (87.5%). Corticosteroid use and invasive devices were common, and prior antibiotic use occurred in most cases. Only 35.0% of patients received antifungal therapy, predominantly fluconazole. Conclusions: Trichosporonaceae infections, particularly those caused by T. asahii, are associated with critically ill patients and high mortality, highlighting the need for early diagnosis, appropriate therapy, and continuous surveillance.Yasmim Passos Lima; Ricardo Villela Bastos; Victor Quinet de Andrade Bastos; Lucas Quinet de Andrade Bastos; João Renato Hipólito; André Netto Bastos; Cláudio Galuppo Diniz; Vania Lucia da Silva; Dias VC

Epidemiology; Intensive care; Antibiotics; Antifungal; Antifungal drugs; Medical record; Critically ill; Medicine; Intensive care medicine; Internal medicine; Emergency medicine; Antimicrobial; Community hospital

2026-02-26https://doi.org/10.3390/jof12030167Journal of Fungi 20261“ <scp>BW90</scp> ”: The Highest Frequency Clicks Ever Recorded for a Beaked WhaleNatália Rodrigues‐Soares; Raphael Barbosa Machado; Yasmin Viana; Artur Andriolo

Beaked whale; Cetacea; Sound production; Bioacoustics; Human echolocation; Biology; Zoology; Geography

2026-03-30https://doi.org/10.1111/mms.70161Marine Mammal Science 20261Transforming jet flavour tagging at ATLASJet flavour tagging enables the identification of jets originating from heavy-flavour quarks in proton-proton collisions at the Large Hadron Collider, playing a critical role in its physics programmes. This paper presents GN2, a transformer-based flavour tagging algorithm deployed by the ATLAS Collaboration that represents a different methodology compared to previous approaches. Designed to classify jets based on the flavour of their constituent particles, GN2 processes low-level tracking information in an end-to-end architecture and incorporates physics-informed auxiliary training objectives to enhance both interpretability and performance. Its performance is validated in both simulation and collision data. The measured c-jet (light-jet) rejection in data is improved by a factor of 3.5 (1.8) for a 70% b-jet tagging efficiency, compared to the previous algorithm. GN2 provides substantial benefits for physics analyses involving heavy-flavour jets, such as measurements of Higgs boson pair production and the couplings of bottom and charm quarks to the Higgs boson, and demonstrates the impact of advanced machine learning methods in experimental particle physics.G. Aad; Erlend Aakvaag; B. Abbott; Sara Abdelhameed; Kira Abeling; Nils Julius Abicht; S. H. Abidi; Mohammed Aboelela; A. Aboulhorma; H. Abramowicz; Y. Abulaiti; B. S. Acharya; Anke Ackermann; C. Adam Bourdarios; L. Adamczyk; Sagar Addepalli; Matthew John Addison; J. Adelman; Aytul Adiguzel; T. Adye; A. A. Affolder; Yoav Afik; M. N. Agaras; A. Aggarwal; C. Agheorghiesei; F. Ahmadov; Sudha Ahuja; X. Ai; G. Aielli; A. Aikot; M. Ait Tamlihat; B. Aitbenchikh; M. Akbiyik; T. P. A. Åkesson; A. V. Akimov; Daiya Akiyama; Nilima Nilesh Akolkar; S. Aktas; G. L. Alberghi; J. Albert; Una Helena Alberti; P. Albicocco; Guillaume Lucas Albouy; S. Alderweireldt; Z. L. Alegria; M. Aleksa; Igor Alexandrov; C. Alexa; T. Alexopoulos; Fabrizio Alfonsi; M. Algren; M. Alhroob; B. Ali; H. M. J. Ali; S. Ali; Samuel William Alibocus; M. Aliev; G. Alimonti; W. Alkakhi; C. Allaire; Benedict Allbrooke; Jonny Allen; Julia Frances Allen; P. P. Allport; A. Aloisio; F. Alonso; C. Alpigiani; Zainab Mohammad K Alsolami; A. Álvarez Fernández; Mario Alves Cardoso; M. G. Alviggi; M. Aly; Y. Amaral Coutinho; A. Ambler; Christoph Amelung; Christoph Amelung; C. G. Ames; Thiziri Amezza; D. Amidei; Baktash Amini; Kyle Amirie; Artem Amirkhanov; S. P. Amor Dos Santos; K. R. Amos; Dimitra Amperiadou; Shiwen An; Christos Anastopoulos; T. Andeen; J. K. Anders; Adam Campbell Anderson; A. Andreazza; S. Angelidakis; A. Angerami; A. V. Anisenkov; A. Annovi; Claire Antel; E. Antipov; M. Antonelli; Fabio Anulli; Masato Aoki

Atlas (anatomy); Flavour; Higgs boson; Large Hadron Collider; Interpretability; Quark; Collision; Jet (fluid); Particle physics; Physics; Nuclear physics; ATLAS experiment; Phenomenology (philosophy); Physics beyond the Standard Model; Hadron; Perturbative QCD; Tracking (education); TRAC; Top quark

2026-01-14https://doi.org/10.1038/s41467-025-65059-6Nature Communications 20261Measurement of coherent exclusive J/ψ → μ+μ− production in ultraperipheral Pb+Pb collisions at $$ \sqrt{s_{\textrm{NN}}}=5.36 $$ TeV with the ATLAS detectorA bstract The ATLAS experiment has performed a measurement of coherent exclusive J/ψ → μ + μ − production in ultraperipheral Pb+Pb collisions at $$ \sqrt{s_{\textrm{NN}}}=5.36 $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msqrt> <mml:msub> <mml:mi>s</mml:mi> <mml:mi>NN</mml:mi> </mml:msub> </mml:msqrt> <mml:mo>=</mml:mo> <mml:mn>5.36</mml:mn> </mml:math> TeV. The data was recorded at the Large Hadron Collider (LHC) during 2023, and corresponds to an integrated luminosity of 79 μ b − 1 . Exclusive J/ψ candidates were selected with a dedicated track-sensitive trigger based on the ATLAS transition radiation tracker. The analysis involves reconstruction of the dimuon invariant mass based on muon tracks from the inner detector, as the muon transverse momentum range of interest precludes the use of the standard muon reconstruction and identification algorithms. Differential cross sections are measured as a function of J/ψ rapidity and are compared with theoretical predictions. After extrapolation to $$ \sqrt{s_{\textrm{NN}}}=5.02 $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msqrt> <mml:msub> <mml:mi>s</mml:mi> <mml:mi>NN</mml:mi> </mml:msub> </mml:msqrt> <mml:mo>=</mml:mo> <mml:mn>5.02</mml:mn> </mml:math> TeV, they are also compared with previous measurements performed by other experiments using data from LHC Run 2. While the results agree reasonably well with theoretical predictions, they are in tension with previous Run-2 results for the central rapidity region.Georges Aad; Erlend Aakvaag; B. Abbott; Sara Abdelhameed; K. Abeling; Nils Julius Abicht; S. H. Abidi; Mohammed Aboelela; A. Aboulhorma; H. Abramowicz; Yiming Abulaiti; B. S. Acharya; Anke Ackermann; C. Adam Bourdarios; L. Adamczyk; S. V. Addepalli; Matthew John Addison; J. Adelman; Aytul Adiguzel; T. Adye; A. A. Affolder; Y. Afik; M. N. Agaras; Anamika Aggarwal; C. Agheorghiesei; F. Ahmadov; S. Ahuja; S. Ahuja; X. Ai; G. Aielli; A. Aikot; M. Ait Tamlihat; B. Aitbenchikh; M. Akbiyik; T. P. A. Åkesson; A. V. Akimov; D. Akiyama; Nilima Nilesh Akolkar; S. Aktas; G. L. Alberghi; J. Albert; Una Helena Alberti; Pietro Albicocco; Guillaume Lucas Albouy; S. Alderweireldt; Z. L. Alegria; Martin Aleksa; C. Alexa; I. N. Aleksandrov; T. Alexopoulos; Fabrizio Alfonsi; M. Algren; M. Alhroob; B. Ali; Hanadi Ali; S. Ali; Samuel William Alibocus; M. Aliev; G. Alimonti; W. Alkakhi; C. Allaire; Benedict Allbrooke; D. R. Allen; J. S. Allen; J. F. Allen; P. P. Allport; A. Aloisio; F. Alonso; C. Alpigiani; Z. M. K. Alsolami; A. Alvarez Fernandez; M. Alves Cardoso; M. G. Alviggi; M. Aly; A. Ambler; Christoph Amelung; M. Amerl; Christoph Ames; Thiziri Amezza; D. Amidei; Baktash Amini; Kyle Amirie; Artem Amirkhanov; S. P. Amor Dos Santos; K. R. Amos; Dimitra Amperiadou; Shiwen An; C. Anastopoulos; T. Andeen; J. K. Anders; Adam Campbell Anderson; Attilio Andreazza; S. Angelidakis; A. Angerami; A. V. Anisenkov; A. Annovi; C. Antel; E. Antipov; M. Antonelli; Fabio Anulli

Rapidity; Large Hadron Collider; Atlas (anatomy); Muon; Extrapolation; ATLAS experiment; Detector; Atlas detector; Physics; Nuclear physics; Particle physics; Invariant mass; Luminosity; Hadron; Transverse plane; Tevatron

2026-04-01https://doi.org/10.1007/jhep04(2026)020Journal of High Energy Physics 20261Global monsoon variability in a 1.5 °C warming climate: Observational changes and end-century projectionsRicky Anak Kemarau; Zulfaqar Sa'adi; Najeebullah Khan; Bassim Mohammed Hashim; Leonardo Goliatt; Sajjad Firas Abdulameer; Zaher Mundher Yaseen‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬; Shamsuddin Shahid

Monsoon; Precipitation; Indian Ocean Dipole; Climate change; East Asian Monsoon; Global warming; Teleconnection; Climatology; Environmental science; Monsoon of South Asia; Observational study; Global change; Tropical monsoon climate; Walker circulation; Climate model; Baseline (sea); Geography

2026-01-09https://doi.org/10.1016/j.atmosres.2026.108765Atmospheric Research 20261In vitro evaluation of different implant systems and their influence on primary stabilityThe aim of this in-vitro study was to compare the primary stability and bone quality changes of three milling systems for implants. Osteotomies were performed on fresh, low-density bovine ribs using three different milling techniques for the Strong SW implant system: conventional drilling according to the manufacturer's protocol (control), osseodensification, and bone expander (n = 5 per group). Prior to implant insertion, bone quality at the cervical, body, and apical regions was assessed using micro-computed tomography. Implants were then placed at the bone level, and primary stability was evaluated by measuring insertion torque with a digital torque meter. Bone quality and insertion torque values were statistically analyzed using one-way ANOVA followed by Tukey's multiple comparison test (p = 0.05). There were no statistically significant differences between the cervical, body, and apical regions, as well as among the implant groups SIN, VERSAH, and MAXIMUS (p < 0.05). Furthermore, the insertion torque of the SIN group (35 ± 21.5 N/cm), VERSAH group (43.2 ± 27.1 N/cm), and MAXIMUS group (59.6 ± 28.5 N/cm) also showed no statistically significant differences (p < 0.05). These findings suggest a similarity in bone microarchitecture and insertion strength among the different implants studied. The three milling techniques demonstrated comparable performance, showing no significant differences in bone microarchitecture or primary stability. These results indicate that all systems provided similar conditions for implant insertion in low-density bone.Osmar de Agostinho Neto; João Víctor Frazão Câmara; Anton Schestakow; Amanda de Oliveira Pinto Ribeiro; Tamara Teodoro Araújo; Sotto-Maior, Bruno Salles, 1981-

Implant; Significant difference; Analysis of variance; Osteotomy; Artificial bone; Biomedical engineering; Dentistry; Materials science; Orthodontics; Medicine

2026-01-09https://doi.org/10.1038/s41598-026-35112-5Scientific Reports 20261Structural and spectroscopic information of a potential magnesium triflate-based electrolyteGabriel R. Lamas; Andrzej Eilmes; Toshio Yamaguchi; Jochi Tseng; Takashi Honda; Wagner A. Alves

Electrolyte; Solvation; Raman spectroscopy; Raman scattering; Ion; Magnesium; Analytical Chemistry (journal); Electrochemistry; Neutron scattering; Chemistry; Inorganic chemistry; Tetrahydrofuran; Conductivity; Atom (system on chip); Chloride; Molecule; Solvation shell; Physical chemistry; Ionic conductivity; Scattering

2026-01-12https://doi.org/10.1016/j.molstruc.2026.145337Journal of Molecular Structure 20261SAPHO—Scalable-Architecture Processor for Hardware Optimization: An FPGA Customizable Implementation ApproachSoft-core processors are increasingly being used in Field Programmable Gate Arrays (FPGAs) to implement complex functions at critical points in embedded systems, where a pure firmware solution would demand excessive development effort or hardware resources. However, most existing processors rely on a fixed architecture, allocating the same amount of logic resources regardless of the application. This typically results in hardware over-provisioning, oversized data word lengths, and unnecessary power consumption. To overcome these limitations, this work presents SAPHO, a self-scalable processor that automatically adjusts its program and data memories as well as its arithmetic and logic circuits according to the software requirements. This design paradigm reduces hardware waste, lowers logic element utilization, and enables more energy-efficient execution compared to conventional soft-core processors. In addition, SAPHO incorporates a combinational Arithmetic Logic Unit (ALU), configurable for fixed or floating-point operations, that guarantees the execution of one instruction per clock cycle without pipeline stalls. Performance evaluation demonstrates that, when compared to a widely adopted commercial soft-core processor (NIOS II), SAPHO achieves lower hardware cost and execution time while maintaining scalability and flexibility for different embedded applications. Experimental results show that SAPHO executes all arithmetic operations in a fixed sequence of 13 clock cycles, whereas equivalent operations on the NIOS II require from tens to thousands of cycles depending on the processor configuration and data type. In an 8-point FFT benchmark, SAPHO reduces execution time by 77.36% compared to the fastest NIOS II configuration. Furthermore, SAPHO requires fewer logic elements (LEs) and exhibits lower dynamic core power consumption, showing a reduction in dynamic core power consumption ranging from 15% to 33% compared with the NIOS II variants. These results demonstrate that SAPHO achieves lower hardware cost and faster execution while maintaining scalability and flexibility for different embedded applications.Eder B. Kapisch; Melissa Santos Aguiar; Luciano M. A. Filho; L. R. M. Silva

Firmware; Field-programmable gate array; Scalability; Pipeline (software); Nios II; Gate array; Clock rate; Reduction (mathematics); Computer science; Embedded system; Computer hardware; Parallel computing; Software; Flexibility (engineering)

2026-01-01https://doi.org/10.1109/access.2026.3652855IEEE Access 20261Noninvasive liver fibrosis assessment in metabolic dysfunction-associated steatotic liver diseaseMetabolic-dysfunction-associated steatotic liver disease (MASLD) is a leading cause of chronic liver disease worldwide, with global prevalence estimated at about 32%. The main predictor of clinical outcome is liver fibrosis severity, making an accurate diagnosis essential. This study evaluated the role and accuracy of noninvasive methods (NIMs) for assessing liver fibrosis in MASLD. A systematic literature search was conducted in the PubMed, Cochrane, SciELO, and LILACS databases using the keywords "metabolic steatotic liver disease", "noninvasive markers", "liver fibrosis", and related terms. A total of 76 articles were selected for review. NIMs offer advantages over liver biopsy due to their simplicity, accessibility, and reproducibility, enabling effective risk stratification at lower costs. Despite some limitations in defining intermediate fibrosis stages, a stepwise approach enhances diagnostic accuracy. Although liver biopsy remains the gold standard, NIMs are increasingly recognized for reliably excluding advanced fibrosis in patients with MASLD, reducing the need for invasive procedures.Tarsila C R Ribeiro; Vitor de Paula Boechat Soares; Julia Campos Fabri; Luiza Esther De Aragão Ramos

Liver biopsy; Liver fibrosis; Fibrosis; Liver disease; Gold standard (test); Fatty liver; Chronic liver disease; Medicine; Gastroenterology; Internal medicine; Biopsy; Steatosis; Disease; Nonalcoholic fatty liver disease; Cirrhosis; Pathology; Hepatic fibrosis; Metabolic syndrome

2026-01-27https://doi.org/10.4254/wjh.v18.i1.111534World Journal of Hepatology 20261Metal–atovaquone complexes with antiplasmodial activity: chemical reactivity and structure–activity relationshipsFive new promising antimalarial metallodrugs (M (Ag, Zn, and Cu)–atovaquone (ATV)) were obtained. These demonstrate potent antimalarial activity, selectivity, and tunable action phenotypes.Luana Vanessa Daniel; Chris Hebert J. Franco; Adrielle Sacramento de Morais; Arquı́medes Karam; Marcelo Cecconi Portes; Milena Barros Silva; Cristiane Barata-Silva; Lisia Maria Gobbo; Joël Mosnier; Isabelle Fonta; Ana Maria da Costa Ferreira; Bruno Pradines; Diogo Rodrigo de Magalhães Moreira; Maribel Navarro

Reactivity (psychology); Antimalarial Agent; Action (physics); Chemical synthesis; Mechanism of action; Chemistry; Combinatorial chemistry; Stereochemistry

2026-01-01https://doi.org/10.1039/d5qi02161hInorganic Chemistry Frontiers 20261Modeling the light response of an optically readout GEM based TPC for the CYGNO experimentAbstract The use of gaseous Time Projection Chambers enables the detection and the detailed study of rare events due to particles interactions with the atoms of the gas with energy releases as low as a few keV. Due to this capability, these instruments are being developed for applications in the field of astroparticle physics, such as the study of dark matter and neutrinos. To acquire events occurring in the sensitive volume with a high granularity, the Cygno collaboration is developing a solution where the light generated during the avalanche processes occurring in a multiplication stage based on Gas Electron Multiplier (GEM) is read out by optical sensors with very high sensitivity and spatial resolution. To achieve a high light output, gas gain values of the order of $$10^5\text {-}10^6$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:msup> <mml:mn>10</mml:mn> <mml:mn>5</mml:mn> </mml:msup> <mml:mtext>-</mml:mtext> <mml:msup> <mml:mn>10</mml:mn> <mml:mn>6</mml:mn> </mml:msup> </mml:mrow> </mml:math> are needed. In this working condition, a dependence of the detector response on the spatial density of the charge collected in the GEM holes has been observed, indicating a gain-reduction effect likely caused by space-charge buildup within the multiplication channels. This paper presents data collected with a prototype featuring a sensitive volume of about two liters, together with a model developed by the collaboration to describe and predict the gain dependence on charge density. A comparison with experimental data shows that the model reproduces, with a percent-level precision, the gain behaviour over nearly one order of magnitude.F. D. Amaro; Rita Antonietti; Elisabetta Baracchini; Luigi Benussi; Stefano Bianco; Roberto Campagnola; C. Capoccia; M. Caponero; Gianluca Cavoto; Igor Abritta Costa; Antonio Croce; Emiliano Dané; Melba D’Astolfo; Giorgio Dho; Flaminia Di Giambattista; Emanuele Di Marco; Giulia D’Imperio; Joaquim Marques Ferreira dos Santos; Davide Fiorina; Francesco Iacoangeli; Z. Islam; Herman Pessoa Lima; E. Kemp; Francesca Lewis; Giovanni Maccarrone; R. D. P. Mano; Robert Renz Marcelo Gregorio; David José Gaspar Marques; Luan Gomes Mattosinhos de Carvalho; Giovanni Mazzitelli; A. G. McLean; Pietro Meloni; Andrea Messina; Cristina Maria Bernardes Monteiro; Rafael Antunes Nobrega; Igor Fonseca Pains; Matteo Pantalena; E. Paoletti; Luciano Passamonti; Fabrizio Petrucci; Stefano Piacentini; Davide Piccolo; D. Pierluigi; D. Pinci; Atul Prajapati; F. Renga; Rita Joana Cruz Roque; F. Rosatelli; A. Russo; Sabrina Salamino; Giovanna Saviano; Federico Francesco Scamporlino; Angelo Serrecchia; P. A. O. C. Silva; Neil John Curwen Spooner; R. Tesauro; Sandro Tomassini; Samuele Torelli; D Tozzi

Detector; Gas electron multiplier; Volume (thermodynamics); Projection (relational algebra); Sensitivity (control systems); Dark matter; Time projection chamber; Dark current; Image resolution; Physics; Optics; Computational physics; Multiplier (economics); WIMP; Multiplication (music); Fermi gas; Data acquisition; Particle detector

2026-02-07https://doi.org/10.1140/epjc/s10052-026-15318-7The European Physical Journal C 20261The 2025–2030 US Dietary Guidelines: an analysis of scientific integrity and global health governanceThe United States (US) has recently released the Dietary Guidelines for Americans 2025–2030. While the policy introduces sound recommendations for vegetables, fruits, and whole grains, and limits added sugars and ultra-processed foods (UPFs) (termed “highly processed foods” within the text), it fails to reflect the contemporary scientific consensus by prioritising animal proteins, animal fats, and full-fat dairy products.1 Additionally, this political position follows a supplementary institutional report that dismisses previous efforts to include health equity and social determinants in the empirical evidence base, labelling such integration a “methodological deficiency”.Felipe Silva Neves; Eduardo Augusto Fernandes Nilson; Larissa Loures Mendes; Neha Khandpur; Marion Nestle

Global health; Corporate governance; Public health; Human health; Global governance; Scientific integrity; Business; Political science; Environmental health; Public administration; Globalization; Economic growth

2026-02-14https://doi.org/10.1016/j.lana.2026.101402The Lancet Regional Health - Americas 20261Toward cardiac electrophysiology digital twins with an efficient open source scalable solver on GPU clustersModelling and simulation are essential in biomedicine, and specifically in computational cardiology. Reliable, efficient and accurate solvers are critical. This study presents an open-source, GPU-based cardiac electrophysiology solver for scalable multiscale simulations (MONOALG3D), incorporating conduction system calibration and performance optimization. The solver employs the monodomain equation coupled with the Purkinje network, solved via the finite volume method, featuring a GPU-based linear solver and concurrent simulation dispatch with MPI. We demonstrate a [Formula: see text] speedup over a CPU-based solution and scalability by running 512 simulations on 128 compute nodes. Coarse and fine biventricular mesh simulations with 855, 670 and 6, 845, 360 control volumes are completed in less than 24 min and 303 min, respectively, considering a single beat and a human-based ventricular cellular model with 43 state variables. The proposed open-source solver enhances computational efficiency and physiological fidelity through Purkinje-muscle-junction calibration, enabling large-scale, high-speed cardiac simulations including the conduction system. This work marks a significant step toward fast and scalable cardiac simulations on GPU architectures by providing execution of concurrent simulations with the novel MPI batch feature and calibration of Purkinje coupling parameters, paving the way for integration into a Digital Twin personalisation pipeline, including the conduction system.Lucas Arantes Berg; Rafael Sachetto Oliveira; Julia Camps; Lucas Marins Ramalho de Lima; Joventino de Oliveira Campos; Zhinuo Jenny Wang; Rubén Doste; Alfonso Bueno-Orovio; Rodrigo Weber dos Santos; Blanca Rodriguez

Solver; Scalability; Speedup; Decoupling (probability); Cardiac electrophysiology; Computation; Massively parallel; Multiscale modeling; Computer science; Parallel computing; Computational science

2026-02-18https://doi.org/10.1038/s41598-025-33709-wScientific Reports 20261Integrated pixel-wise remote sensing and explainable machine learning for natural hydrogen exploration in southeastern part of Pricaspian Basin, Western Kazakhstan) emerges as a clean energy resource generated by different geological processes in multiple geological contexts. Current hydrogen exploration activities rely mainly on surface geochemical surveys focused on diagnostic morphological expressions. Analogous to the early stages of hydrocarbon exploration, these first-pass indicators are used to delineate prospective corridors and rank targets, thereby de-risking and guiding subsequent subsurface investigations. However, these surface expressions remain elusive due to sparse sampling and the absence of robust detection workflows. This study presents a machine learning-based remote sensing technique for pixel-wise hydrogen prospectivity mapping applied on the Atyrau region in the southeastern part of the petroliferous Pricaspian Basin, western Kazakhstan. We utilize Sentinel-2 Level-2 A imagery and extract 13 spectral bands (B1-B12, B8A), 5 spectral indices (e.g., NDVI, NDWI), and 4 texture features, forming a 22-dimensional input feature space. Four classifiers, Random Forest (RF, [Formula: see text]), eXtreme Gradient Boosting (XGB, [Formula: see text], max depth = 5), Stochastic Gradient Descent (SGD, loss = log), and LightGBM (LGBM, learning rate = 0.1), were trained on 120,560,400 labeled pixels with 4,621,344 positive labels derived from high-confidence expert polygons. Performance metrics revealed strong recall for XGB (91.8%) and LGBM (93.1%), albeit with lower precision (6.8% and 6.4% respectively), reflecting class imbalance and rare-event detection challenges. The ROC AUC ranged from 0.50 (SGD) to 0.81 (XGB), with Precision-Recall AUC peaking at 0.17 for RF. Explainable AI techniques based on SHAP (SHapley Additive Explanations) were applied to quantify pixel-wise feature contributions for each classifier. SHAP attributions, overlaid on geologic cross-sections, revealed spatial correlations with known faults and surface anomalies. Final predictions, rasterized into labeled GeoTIFFs at 10 m resolution, indicate locations of anomalies. These promising screening-type exploration results allow for narrowing down areas for direct surface measurements and focusing on understanding the hydrogen system and play concepts. This demonstrates that workflow provides a scalable, interpretable, and cost-effective methodology for natural hydrogen exploration and can be adapted to other data-sparse basins worldwide.Dennis Delali Kwesi Wayo; Leonardo Goliatt; Randy Hazlett; Milovan Fustic; Mahmoud Leila

Prospectivity mapping; Random forest; Gradient boosting; Feature (linguistics); Pixel; Pattern recognition (psychology); Stochastic gradient descent; Boosting (machine learning); Remote sensing; Artificial intelligence; Computer science; Geology; Machine learning; Receiver operating characteristic

2026-02-26https://doi.org/10.1038/s41598-026-41845-0Scientific Reports 20261Microparticulated whey proteins: a literature reviewMicroparticulated whey protein (MWP) was created with the purpose of being used as a fat substitute in various foods. Over the years, it has been demonstrated that its use can also be applied to modulate sensory, textural, and stability characteristics. Several mechanisms can be applied for its production, but in general it is necessary to apply heat and shear to denature the proteins and control the size of the aggregates formed. The composition of the protein solution being microparticulated is also a fundamental factor affecting the characteristics of the MWP; parameters such as type of protein, protein concentration, salt and carbohydrate content, as well as pH adjustment, and the intensity of thermal treatment and shear applied are essential in the process. We present an updated review on whey protein microparticulation, compiling the physico-chemical and processing literature data on the subject matter.Igor de Paula; Paola F. Lazzarini; Alan F. Wolfschoon-Pombo; T. Spiegel; José Toro-Sierra; Rodrigo Stephani

Dairy industry; Ultrafiltration (renal); Whey protein; Rheology; Milk products; Chemistry; Chromatography; Food science

2026-03-04https://doi.org/10.1016/j.idairyj.2026.106617International Dairy Journal 20261VIOLÊNCIAS PROTAGONIZADAS POR TREINADORES NO FUTSAL DE MULHERESEste estudo teve como objetivo identificar as violências protagonizadas por treinadores/as presentes nas narrativas de mulheres atletas do futsal. Trata-se de uma pesquisa qualitativa, cujos dados foram coletados por meio de entrevistas semiestruturadas realizadas com seis atletas residentes em Juiz de Fora/MG. A análise foi conduzida com base na técnica de Análise de Conteúdo temática. Os resultados evidenciaram que todas as participantes relataram ter vivenciado ou presenciado algum tipo de violência no contexto esportivo, caracterizadas como violência de gênero, simbólica, assédio moral, negligência, violência psicológica e física. Constatou-se a normalização dessas práticas violentas, bem como a carência de letramento das atletas sobre as violências no esporte. Recomenda-se promover ações formativas voltadas à prevenção e enfrentamento das violências de gênero no esporte, tanto para atletas quanto para treinadores/as, contribuindo para a construção de ambientes esportivos mais éticos, seguros e inclusivos.Bárbara Aparecida Bepler Pires; Ana Beatriz Torres da Silva; Ludmila Nunes Mourão; Jefferson da Silva Novaes

Athletes; Context (archaeology); Duration (music); Qualitative research; Test (biology); Humanities; Sociology; Psychology

2026-03-17https://doi.org/10.66104/0113vz67Revista Multidisciplinar do Nordeste Mineiro 20261Manuscript Rejection on the Pretext of “Limited Space”: An Ethical and Economic DilemmaFawad Javed; Zain Uddin Ahmed; Fernanda Oliveira Bello Correa; Khalid Almas

Pretext; Publishing; Transparency (behavior); Dilemma; Medical law; Function (biology); Scientific progress; Ethical dilemma; Public relations; Sociology; Political science; Engineering ethics; Law; Research integrity; Space (punctuation); Law and economics; Project commissioning; Research ethics; Scholarly communication; Scientific misconduct

2026-03-23https://doi.org/10.1007/s11673-025-10537-1Journal of Bioethical Inquiry 20261Global, regional and national burden of ischemic heart disease attributable to suboptimal diet, 1990–2023: a Global Burden of Disease studyGBD 2023 IHD & Dietary Risk Factors Collaborators; Sooji Lee; Hayeon Lee; Yejun Son; Jae Il Shin; Hasan Aalruz; Yohannes Abate; Cristiana Abbafati; Nasir Abbas; Elahe Abbaspour; Hedayat Abbastabar; Samar Abd ElHafeez; Parsa Abdi; Wakgari Mosisa Abdisa; Mohammad Abdollahi; Meriem Abdoun; Rizwan Suliankatchi Abdulkader; AS Abdullahi; Olugbenga Olusola Abiodun; Olumide Abiodun; Richard Gyan Aboagye; Shady Abohashem; L. G. Abreu; Dariush Abtahi; Aminu Kende Abubakar; Bilyaminu Abubakar; Eman Abu-Gharbieh; Hana J Abukhadijah; Salahdein Aburuz; Ahmed Abu-Zaid; Mesafint Molla Adane; Isaac Yeboah Addo; Oladimeji Muritala Adebayo; Kamoru A. Adedokun; Rufus Adesoji Adedoyin; Charles Oluwaseun Adetunji; Juliana Bunmi Adetunji; Temitayo Esther Adeyeoluwa; K. R. Adhikari; Usha Adiga; Qorinah Estiningtyas Sakilah Adnani; Aanuoluwapo Adeyimika Afolabi; Arya Afrooghe; Muhammad Sohail Afzal; Saira Afzal; Prerna Agarwal; Feleke Doyore Agide; Williams Agyemang-Duah; Bright Opoku Ahinkorah; Aqeel Ahmad; Danish Ahmad; Firdos Ahmad; Muayyad M Ahmad; Sajjad Ahmad; Ali Ahmadi; Ayman Ahmed; Haroon Ahmed; M Ahmed; Mushood Ahmed; Syed Anees Ahmed; Marjan Ajami; Budi Aji; Mohammed Ahmed Akkaif; Alaa Al Amiry; Salah Al Awaidy; Mohammad Al Qadire; Tariq A. Alalwan; Ziyad Al-Aly; Khurshid Alam; Fahmi Y. Al-Ashwal; Mohammed ALBashtawy; Khalifah A Aldawsari; Wafa Ali Aldhaleei; Abdelazeem M. Algammal; Fadwa Naji Alhalaiqa; Abid Ali; Akhtar Ali; Endale Alemayehu Ali; Mohammed K. Ali; Mohammed K. Ali; Rafat Ali; Syed Shujait Ali; Waad Ali; Gianfranco Alicandro; Sheikh Mohammad Alif; Samah W. Al-Jabi; Syed Mohamed Aljunid; Ahmad Alkhatib; Sabah Al-Marwani; Mohmmad Minwer Alnaeem; Mahmoud A. Alomari; Saleh A. Alqahtani; Ahmad Alrawashdeh; Sahel Majed Alrousan; Mohammed Alsabri; Wafa Mohammed Alseragi; Zaid Altaany; Awais Altaf; Nelson Rafael el Alvis-Guzmán; Hassan Alwafi

Burden of disease; Disease; Disease burden; Cause of death; Population; Confidence interval; Global health; Medicine; Environmental health; Mortality rate; Epidemiology; Ischaemic heart disease; Population ageing; Attributable risk; Heart disease; Emergency medicine

2026-03-30https://doi.org/10.1038/s41591-026-04250-8Nature Medicine 20261Transcultural headache medicine: A framework for integrating cultural contexts into headache science and care – a call to action from the International Headache SocietyHeadache disorders are among the most disabling neurological conditions, affecting over 1.5 billion people globally. Despite advances in pharmacological therapies, major inequities persist due to underdiagnosis, undertreatment and limited access to effective care, particularly in low- and middle-income countries. Social determinants of health, including cultural meanings, language and health beliefs, are increasingly recognized as key drivers of disparities in burden, diagnosis and treatment outcomes. Traditional medicine, used by more than 80% of the global population, remains first-line care in many regions and continues to influence therapeutic choices in high-income settings. Major systems such as Ayurveda, Traditional Chinese Medicine, Unani and Tibetan medicine, as well as diverse indigenous traditions, emphasize holistic approaches that integrate mental and physical symptoms into diagnosis and management. Additionally, religious and spiritual practices are commonly used to relieve suffering and pain. These culturally grounded explanatory models not only strongly shape health-seeking behavior, treatment adherence and patient narratives, but also may delay biomedical care when misconceptions or unsafe practices predominate. This paper introduces Transcultural Headache Medicine as an emerging framework that integrates cultural contexts, linguistic diversity and traditional practices into headache research, clinical care and policy. We review global traditions and therapeutic modalities including herbal, physical, mental and spiritual approaches, and propose a research agenda combining ethnography, culturally adapted diagnostic tools, experimental studies and clinical trials to evaluate benefits, risks, and contextual effects. We conclude with a call to action from the International Headache Society, aiming to map and evaluate culturally embedded practices, strengthen rigorous evidence and build a global learning network that supports culturally safe integration of effective, affordable and safe headache care.Mario F P Peres; Giancarlo Lucchetti; Homero Vallada; Ivy Liger Riso; Georgia Kleinschmitt Westenhofen; Marcelo Moraes Valença; Juliana Ramos de Andrade; K. C. Brennan; Morris Levin; Tsubasa Takizawa; Zhao Dong; Yonggang Wang; Wanakorn Rattanawong; Henry Riyanto Sofyan; Massimo Leone; Freda Dodd-Glover; Hsiangkuo Yuan; Abdulrazaq Albilali; Taoufik Alsaadi; Leonardo Caixeta; Anna P. Andreou; Peter J. Goadsby; Antoinette MaassenVanDenBrink; Sait Ashina; Rami Burstein; Patricia Pozo-Rosich; Fayyaz Ahmed; Shuu-Jiun Wang

Modalities; Call to action; Indigenous; Action (physics); Culturally appropriate; Cultural diversity; Diversity (politics); Alternative medicine; Mental health; Medicine; Health care; MEDLINE; Psychiatry; Comprehension; Clinical trial; Mental illness; Cultural competence; Psychological intervention; Psychotherapist; Culturally sensitive; Nursing; Medical education; Global mental health

2026-03-31https://doi.org/10.1177/03331024261432929Cephalalgia 20261ADOLESCENT BODY DISSATISFACTION: A NARRATIVE REVIEW OF CONCEPTS AND ASSOCIATED FACTORSObjective: To analyze concepts and factors associated with body dissatisfaction in adolescents. Material and Methods: This narrative and integrative literature review synthesizes definitions of body image and evidence on sociocultural determinants and related outcomes, including assessment instruments reported in studies with adolescent populations. Results: Body image is a complex, multidimensional construct comprising perceptual and attitudinal components, and body dissatisfaction is emphasized as part of the attitudinal dimension, expressed as discomfort and negative feelings about one’s appearance. Media, family, and peers contribute to the internalization of socially prescribed beauty ideals, increasing vulnerability during adolescence. Negative body evaluation is associated with disordered eating behaviors and may contribute to outcomes such as eating disorders, depressive symptoms, and social withdrawal. Conclusion: Body dissatisfaction in adolescence is prevalent and multifactorial; broader use of validated assessment protocols and measures for the Brazilian population is needed to support effective preventive strategies and early interventions.Júlio Rafael Assunção De Faria; Bruna Priscila Colombo; Bruno Pereira de Moura; Natiele Resende Bedim; Naruna Pereira Rocha; Maria Elisa Caputo Ferreira; Vinicius Ramos Rezende; Valter Paulo Neves Miranda

Feeling; Narrative; Vulnerability (computing); Perception; Population; Construct (python library); Narrative review; Beauty; Psychology; Developmental psychology; Eating disorders; Social psychology; Conceptualization; Identity (music); Clinical psychology; Sociocultural evolution; Human physical appearance; Categorization

2026-04-13https://doi.org/10.66104/9nhfxt56Revista Multidisciplinar do Nordeste Mineiro 20261Patients with chronic kidney disease stage 3b: do general practitioners and nephrologists follow KDIGO guidelines?BACKGROUND: Appropriate referral and management of patients with chronic kidney disease (CKD) from primary care to nephrologists are essential to prevent disease progression and complications. OBJECTIVES: To describe the demographic and follow-up characteristics of patients with CKD stage 3b at the time of nephrology referral, the medical care offered by general practitioners, and the initial care provided by nephrologists in the Brazilian Unified Health System (SUS). METHODS: This retrospective cohort study included all patients with CKD stage 3b on the waiting list for nephrology consultation between January 2018 and January 2020 in a large city in southern Brazil. Sociodemographic data, comorbidities, and adherence to follow-up recommendations based on the 2021 Kidney Disease: Improving Global Outcomes (KDIGO) guidelines were analyzed. Laboratory test requests and results were compared between the periods of general practitioner care and the period following nephrology consultation. RESULTS: A total of 211 patients (mean age 74 ± 12 years) were included; 76.0% were hypertensive and 46.9% had diabetes. Approximately half had an adequate number of primary care appointments. Laboratory monitoring was suboptimal in both primary and specialized care. Before nephrology consultation, hemoglobin and urinalysis were available for 32.2% and 19.4% of patients, respectively. After consultation, hemoglobin and potassium results were documented in 68.3% and 58.8% of patients, respectively. CONCLUSION: Although patients with CKD stage 3b were regularly followed, low adherence to KDIGO testing recommendations raises concerns about the adequacy of care. Strengthening communication and guideline implementation between primary care and nephrology services is crucial to improve CKD management within the SUS.Juliana Gazzi Macedo; Alessandra Maciel Almeida; Helady Sanders‐Pinheiro; R. A. Fabreti‐Oliveira

Nephrology; Kidney disease; Referral; Guideline; Primary care; Retrospective cohort study; Stage (stratigraphy); Cohort; Health care; Medicine; Internal medicine; Intensive care medicine; Disease management; Disease; Urinalysis; Emergency medicine; Cohort study; Dialysis; Comorbidity; MEDLINE

2026-01-01https://doi.org/10.1590/2175-8239-jbn-2025-0229enBrazilian Journal of Nephrology 20261Chitosan-Based Nanoparticles for Nose-to-Brain Drug Delivery: A Real Path toward Effective CNS Therapy?Treating central nervous system (CNS) disorders remains a major clinical challenge. The blood-brain barrier (BBB), systemic toxicity, and first-pass metabolism are key obstacles. These factors limit the effective drug delivery to the brain. Intranasal administration has emerged as a noninvasive strategy to bypass the BBB. This approach enables direct drug delivery to the brain through the olfactory and trigeminal nerve pathways, commonly referred to as nose-to-brain (N2B) delivery. In this context, chitosan (CS), a biocompatible and mucoadhesive polysaccharide with permeation-enhancing properties, has gained significant interest as a functional material for nanoparticle (NP) engineering. CS-based or CS-coated NP can prolong the residence time on the nasal mucosa and facilitate drug transport to the CNS. This review provides a comprehensive overview of recent advances in CS-based NP for N2B drug delivery across a range of CNS disorders, including neurodegenerative, neuropsychiatric, neoplastic, and infectious conditions. Particular attention is given to formulation strategies, mechanistic insights, and preclinical outcomes. Recent patent applications are surveyed to underscore the translational potential and commercial interest in this technology. Collectively, CS-based NPs effectively address major therapeutic barriers, establishing a transformative and innovative platform in CNS drug delivery.Lorena Rodrigues Riani; Gustavo F. B. Seno; Dominique M. Silva; Cibele R. Toledo; Mayara R. B. Paiva; Júlia S. Santos; Rodrigo L. Fabri; Frederico Pittella; Guilherme D. Tavares

Drug delivery; Nasal administration; Drug; Nanomedicine; Biocompatible material; Targeted drug delivery; Blood–brain barrier; Nanotechnology; Medicine; Neuroscience; Central nervous system; Pharmacology; Drug carrier; Drug discovery

2026-04-23https://doi.org/10.1021/acsbiomaterials.6c00137ACS Biomaterials Science & Engineering 20261EPI-CKD Brazil: point-of-care screening for chronic kidney disease during World Kidney DayINTRODUCTION: Chronic kidney disease (CKD) is a public health issue, with an estimated prevalence of 10% in Brazil, possibly underestimated due to regional inequalities and diagnostic limitations. The EPI-CKD Brazil study aimed to estimate the prevalence of estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m2 in adults with risk factor for CKD, using point-of-care creatinine testing (POCTcr) during World Kidney Day 2025, and to assess regional variations and associated predictors. METHODS: We conducted a multicenter cross-sectional study across 20 state chapters of the Brazilian Society of Nephrology, including individuals ≥ 18 years with at least one CKD risk factor (age > 60 years, hypertension [HTN], diabetes mellitus [DM], cardiovascular disease, obesity, chronic use of nonsteroidal anti-inflammatory drugs, history of acute kidney injury, bilateral kidney stones, or family history of CKD). Renal function was assessed using a rapid creatinine test (NovaMaxPro®-eGFR CKD-EPI 2021). Reduced eGFR was defined as < 60 mL/min/1.73 m2. RESULTS: We analyzed 8,374 participants (66.9% women; median age, 58 years; BMI, 28.3 kg/m2; 46.2% mixed race). The frequency of reduced eGFR was 40.2% (n = 3,370), of whom 36% were in stages G3b-G5. Only 35.2% were aware of CKD risk factors. Significant regional differences were observed (ranging from 27.9% [Bahia] to 55.2% [Paraná]; p < 0.001). Independent predictors included age (OR = 1.032; 95%CI: 1.028-1.035), HTN (OR = 1.27; 95%CI: 1.15-1.40), and indigenous ethnicity as a protective factor (OR = 0.40; 95%CI: 0.20-0.89; p < 0.05). Risk increased by 23% for each additional risk factor. CONCLUSION: A high frequency of reduced eGFR and low awareness of CKD risk factors were observed. The study demonstrates the feasibility of POCTcr in screening strategies and reinforces the need for public policies to expand early diagnosis and strengthen primary care.Viviane Calice-Silva; Patrícia Abreu; Maria Eliete Pinheiro; Ana Katarina de Cerqueira Delgado Lopes; Karla Cristina Petruccelli Israel; Ana Wanda Barreto Marinho; Ana Flavia Moura; Felipe Costa Neves; Cláudia Maria Costa de Oliveira; Silvana Daher Costa; Luiz Roberto de Sousa Ulisses; Fábio Humberto Ribeiro Paes Ferraz; Ramiele Aparecida Cruz Souza; Rachel Gatti Armani; Ciro Bruno Silveira Costa; Marcelo Garcia Tavares; Dyego Jose de Araujo Brito; Érika Cristina Ribeiro de Lima Carneiro; Luiz Gonzaga Filho; Jenaine Oliveira Paixão; Helady Sanders‐Pinheiro; Luís Cláudio Santos Pinto; Lucas Acatauassu Nunes; Pablo Rodrigues Costa Alves; Amanda Maíra Damasceno Silva; Rene Scalet Dos Santos Neto; Suzana Ricardo Greffin; Gisele Vajgel; J. Andrade; GINIVALDO VICTOR RIBEIRO DO NASCIMENTO; Igor Denizarde Bacelar Marques; Maria Izabel de Holanda; Pedro Tulio Monteiro de Castro Abreu Rocha; Kalyanne Cabral de Paula do O; Lelyanne Rodrigues Pereira Torauato; Cristina Karohl; Juliana Alves Manhães de Andrade; Ariane Karen de Sousa; Denise Rodrigues Simão; Ana Carolina Nakamura Tome; Daniela [UNESP] Ponce; Fernanda Salomão Gorayeb-Polacchini; Maria Almerinda Vieira Fernandes Ribeiro Alves; Rubens Escobar Pires Lodi; Cinthia Montenegro; José A. Moura-Neto

Kidney disease; Renal function; Diabetes mellitus; Risk factor; Creatinine; Family history; Kidney; Disease; Medicine; Internal medicine; Epidemiology

2026-01-01https://doi.org/10.1590/2175-8239-jbn-2025-0298enBrazilian Journal of Nephrology 20261Designing Diaryl Sulfide Electronic Properties: A Comprehensive DFT Guide to HOMO–LUMO Gaps and Reactivity Descriptorsexhibits the highest electrophilicity (6.931 eV). For dipole moment calculations, B1LYP emerges as the most accurate functional (MAE = 0.246 D), closely followed by B3LYP (MAE = 0.262 D). In contrast, the TPSSh (MAE ≈ 0.20 eV) and B3PW91 (MAE ≈ 0.17 eV) functionals are recommended for exploratory studies requiring reliable vertical transition energies.Ramon S. da Silva

Reactivity (psychology); Density functional theory; Sulfide; Catalysis; Electronic structure; Chemistry

2026-05-01https://doi.org/10.1021/acsomega.5c11432ACS Omega 20261Barreiras para o encaminhamento para transplante renal no estado de Minas Gerais na percepção dos nefrologistasResumo Introdução: Há baixa porcentagem de pacientes na lista de espera para transplante renal (TxR) no Brasil, mesmo em um sistema público de saúde com cobertura integral. Dos fatores que influenciam o encaminhamento, os relacionados ao nefrologista são os menos estudados. Nosso objetivo foi investigar as barreiras ao encaminhamento para avaliação para TxR sob a perspectiva de nefrologistas em Minas Gerais. Métodos: Estudo transversal com amostra de conveniência de nefrologistas atuantes no estado. Foram coletadas, por questionário eletrônico, as seguintes informações: características demográficas, formação, atuação, conhecimento sobre indicações (6) e contraindicações (12) e perfil de prática. Análises não paramétricas foram realizadas. Resultados: Os 77 nefrologistas tinham idade mediana de 44,9 anos (IIQ 39–52), 12,5 anos (IIQ 3–23) de atuação e todos tinham pós-graduação. A mediana de respostas esperadas sobre as contraindicações foi 8 (IIQ 6–9) em 12 possíveis, com 66,2% acertando mais de 50% das questões. Não houve associações significativas com este padrão de respostas (< 8). Os nefrologistas referem conhecer o processo e alegam a presença de contraindicações como principal causa para o não encaminhamento. Os centros eram públicos (54,5%) e não acadêmicos (55,8%), 69,2% estavam localizados a < 100 km de um centro de TxR, a maioria (80,4%) oferecia TxR como modalidade de tratamento, somente 14,7% relataram dificuldades com exames pré-TxR e 21–40% dos pacientes estavam listados (31,2%). Conclusão: Identificamos falhas no conhecimento das contraindicações para TxR e na percepção de risco como causas para o não encaminhamento. Não foram observadas limitações no nível dos centros ou do sistema. Os resultados fundamentam ações de educação e maior integração entre serviços de nefrologia e centros transplantadores para viabilizar o encaminhamento.Cristianne de Medeiros Nogueira; Luiza Cunha MARTINS; Helady Sanders‐Pinheiro

Transplantation; Kidney transplantation; Incidence (geometry); Population; Kidney disease; Medicine; Gynecology

2026-01-01https://doi.org/10.1590/2175-8239-jbn-2025-0215ptBrazilian Journal of Nephrology 20261Relato de experiência: diagnóstico situacional dos comitês de equidade municipais de uma microrregião de saúde do leste de Minas GeraisO Programa de Educação pelo Trabalho para a Saúde (PET-Saúde) é uma estratégia que visa promover a equidade no acesso e na qualidade da formação dos profissionais de saúde no Brasil. Por meio dele, estudantes têm a oportunidade de compreender melhor as desigualdades sociais e as necessidades específicas de diferentes grupos populacionais. O objetivo deste relato foi compartilhar a metodologia, discussão e resultados inferidos dessa experiência, ressaltando a importância da promoção da equidade e o papel fundamental dos Comitês de Equidade. Para o diagnóstico situacional, foi aplicado um questionário estruturado a gestores e representantes municipais da microrregião de Governador Valadares. O instrumento investigou a existência, a estrutura e o funcionamento dos comitês, além de identificar desafios e estratégias adotadas na promoção da equidade. Os resultados apontaram que o principal obstáculo é o desconhecimento sobre o papel e as temáticas dos comitês, o que compromete sua eficácia e o desenvolvimento de ações efetivas. A análise dos dados revelou três descritores centrais: resistência institucional, falta de capacitação sobre equidade e ausência de diagnóstico situacional. Esses achados reforçam a relevância do PET-Saúde como indutor de práticas transformadoras, fortalecendo os comitês e apoiando os municípios na promoção da equidade entre trabalhadoras e trabalhadores da saúde.Júnior César da Silva; Aline Martins Lima; Amanda Soares Gonzaga Lopes; Ana Carolina Torres Pereira; Bárbara Moreira Faria; Bruna Graziela Pena de Assis; Raissa Silva da Paz; Sara Júlia Alves Canazart Silva; Wemily Souza Cardoso; Bráulio de Magalhães Santos; Rodrigo Furtado de CARVALHO

Equity (law); Work (physics); Scope (computer science); Context (archaeology); Order (exchange); Political science; Humanities; Sociology; Public administration

2026-01-07https://doi.org/10.33448/rsd-v15i1.50487Research Society and Development 20261Decoupling abundance and biomass in secondary Atlantic Rainforest: Differential responses of rare and common tree species to environmental driversOtávio Miranda Verly; Pedro Manuel Villa; Marcelo Vitor Gualberto Santos Chaves; Samuel José Silva Soares da Rocha; Luiz Claudio Medeiros Cabral-da-Silva; Klisman Oliveira; Maria Paula Miranda Xavier Rufino; S. Vieira; D'lano Figueiredo Teixeira Sathler; Jacinto Moreira de Lana; Carlos Moreira Miquelino Eleto Torres

Abundance (ecology); Dominance (genetics); Basal area; Biomass (ecology); Forest dynamics; Common species; Species diversity; Population; Ecology; Biology; Relative species abundance; Environmental science; Forest ecology; Taxonomic rank; Environmental change; Relative abundance distribution; Ecosystem; Forest inventory

2026-01-14https://doi.org/10.1016/j.foreco.2026.123503Forest Ecology and Management 20261Light‐emitting diode photobiomodulation on rheumatoid arthritis and osteoarthritis: In vitro and in vivo studiesLight-emitting diodes (LEDs) are light sources that can be used for photobiomodulation to treat various diseases and clinical conditions. Growing evidence suggests that photobiomodulation is a promising treatment for rheumatoid arthritis (RA) and osteoarthritis (OA) because of its analgesic and anti-inflammatory effects. However, such evidence is primarily based on studies evaluating low-power laser-based photobiomodulation, and few studies have assessed the efficacy of LED photobiomodulation in the treatment of RA and OA. Thus, this study aimed to review studies on LED photobiomodulation for the treatment of RA and OA, summarizing the irradiation parameters and conditions, and reporting the study types and main results. Studies on the effects of LED photobiomodulation on RA and OA were accessed via PubMed. Data from accessed studies show that LED photobiomodulation has been carried out with red and infrared LEDs based on in vitro and in vivo experimental models. This therapy may decrease arthritic markers, including edema, hyperalgesia, inflammation, cartilage degradation, extracellular matrix alterations, and proinflammatory cytokine levels. LED photobiomodulation could be as effective a therapy as laser photobiomodulation, but further clinical studies are necessary to verify its therapeutic benefits in both RA and OA.Adenilson de Souza da Fonseca; Flávia Regina De Paoli

Rheumatoid arthritis; In vivo; Osteoarthritis; Proinflammatory cytokine; Human studies; Arthritis; In vitro; Low level laser therapy; Medicine; Pharmacology; Cartilage; Light therapy; Cytokine; Animal studies; Clinical trial; Bioinformatics

2026-02-02https://doi.org/10.1111/php.70077Photochemistry and Photobiology 20261Global Pathways to Net ZeroThis study evaluated corporate alignment with the 2050 Net Zero Emissions targets, a cornerstone of the global transition to a low-carbon economy as mandated by the Paris Agreement. Utilizing the Transition Pathway Initiative (TPI) framework, as endorsed by OECD reports, we analyzed the carbon performance of 2,028 firms across 24 sectors and 28 countries. Companies are scored on a 0–5 scale, with 5 indicating the highest alignment with net-zero goals. Through descriptive statistics, statistical analyses, and hierarchical clustering, we assessed performance variations by firm size, sector, and countries, comparing their alignment with Paris-Compliant Pathways. Results reveal that larger firms, sectors such as telecommunications and oil & gas, and European countries like Denmark and France exhibit superior carbon management, while smaller firms, carbon-intensive sectors like coal mining, and regions like China and the Middle East lag. These findings reveal sectoral and regional disparities, offering actionable insights to guide decarbonization efforts by policymakers and investors.İhsan Erdem Kayral; Melike Aktaş Bozkurt; Tiago Silveira Gontijo; Gustavo de Souza Groppo; Leonardo Goliatt

Cornerstone; China; Carbon fibers; Statistical analysis; Middle East; Zero (linguistics); Low-carbon economy; Business; Economic geography; Economics; Economy; Regional science; Net (polyhedron); Transition (genetics); Natural resource economics; Descriptive statistics; Input–output model; Industrial organization; Economic system

2026-02-05https://doi.org/10.4018/979-8-3373-5238-1.ch014Advances in computational intelligence and robotics book series 20261Development and experimental evaluation of a passive base isolation system using superelastic NiTi SMA springsSuperelastic (SE) response of shape memory alloys (SMAs) offers significant potential for base isolation (BI) systems by reducing superstructure deformations and improving structural safety. This study presents a novel isolation device integrating steel sliding bearings with SE NiTi spring attenuators, designed to provide self-centering capacity and energy dissipation through reversible phase transformations. The attenuator configuration was optimized using a custom-developed algorithm to balance isolation efficiency with displacement control. To evaluate performance, an array of SMA springs was incorporated into a three-story steel frame prototype with three degrees of freedom, tested experimentally on a shake table. For comparison, a conventional elastic spring was also employed, and both systems were subjected to recorded earthquake ground motions. Results for the SE isolation device (SEID) showed that substituting steel with SMA springs reduced structural stiffness by 69%. Calibration confirmed consistent behavior across spring pairs, with maximum deviations of 17.3% due to material nonlinearity. Adoption of shorter springs with fewer coils improved efficiency, reducing oscillating mass by 42%. Modal testing further demonstrated amplitude reductions of 80% under seismic excitations and 91% under forced vibration, validating the SEID as an effective solution for diverse dynamic loading conditions.Yuri José Oliveira Moraes; Felipe Silva Lima; Antônio Almeida Silva

SMA*; Nickel titanium; Base isolation; Shape-memory alloy; Base (topology); Materials science; Structural engineering; Isolation (microbiology); Pseudoelasticity; Mechanical engineering; Composite material

2026-02-17https://doi.org/10.1080/15376494.2026.2619624Mechanics of Advanced Materials and Structures 20261Structural modifications induced by high pressure homogenization under acidic and alkaline conditions improve the functionality of pequi almond (Caryocar brasiliense Camb.) proteinsPequi almond ( Caryocar brasiliense Camb.) is a protein-rich agro-industrial by-product. However, the application of pequi almond protein (PAP) is limited by its low solubility. High pressure homogenization (HPH) combined with pH modulation is a promising strategy to overcome this limitation. In this study, PAP was processed by HPH at acidic (pH 2.0) and alkaline (pH 10.0) conditions using pressures of 60-120 MPa for one cycle. Structural analyses, including particle size, zeta potential, polydispersity index, FTIR and Raman spectroscopy, intrinsic fluorescence, and free sulfhydryl groups, were performed at the respective processing pH. In macrostructural terms, HPH reduced particle size (<81%) and improved protein dispersion, as evidenced by a decrease in the polydispersity index (<54%). At the molecular level, HPH induced pH-dependent structural rearrangements, with an increase in random structures at pH 2.0, indicating partial denaturation, and a predominance of more ordered structures (α-helix and β-turns) at pH 10.0, suggesting controlled molecular association and structural reorganization. Intrinsic fluorescence and sulfhydryl group analyses confirmed HPH-induced conformational changes, reflected by increased exposure of aromatic residues and free-SH groups. Solubility and colloidal stability were subsequently evaluated at pH 6.0. Under these conditions, HPH pretreatment enhanced PAP solubility, reaching 63.5% after alkaline processing at 100 MPa, and improved colloidal stability, as demonstrated by a reduction of up to 85.4% in the Turbiscan Stability Index (TSI). Overall, these results demonstrate that HPH is an effective strategy to tailor PAP structure and enhance its functional performance, supporting its potential application in plant-based beverages, emulsion-based products, and nutritional supplements. • HPH processing under acidic and alkaline conditions modulated PAP structure • Multi-spectroscopic analyses revealed protein unfolding after HPH treatment • HPH, mainly under alkaline conditions, increased PAP solubility measured at pH 6.0 • Particle size reduction induced by HPH improved protein dispersion and colloidal stabilityFábio Ribeiro dos Santos; Jeferson Silva Cunha; Irene Andressa; Flaviana Coelho Pacheco; Julliana da Fonseca Alves; Luiz Fernando Cappa de Oliveira; Ana Flávia Coelho Pacheco; Márcia Cristina Teixeira Ribeiro Vidigal; Bruno Ricardo de Castro Leite Júnior

Dispersity; Zeta potential; Solubility; Homogenization (climate); Particle size; Colloid; Fourier transform infrared spectroscopy; Chemistry; Raman spectroscopy; Chromatography; Fluorescence; Protein secondary structure; Chemical engineering; Nuclear chemistry; Denaturation (fissile materials)

2026-02-26https://doi.org/10.1016/j.foodhyd.2026.112598Food Hydrocolloids 20261Phylogenetic diversity recovery along Atlantic Forest succession: The potential for conserving evolutionary historyUnderstanding the recovery of phylogenetic diversity during tropical forest succession is critical for informing ecosystem stability, conserving evolutionary history, and guiding restoration. To address these goals, we evaluated patterns of phylogenetic diversity, structure, and lineage turnover across 61 s-growth and 18 old-growth forest communities in three regions of the Brazilian Atlantic Forest. We asked whether second-growth forests recover the phylogenetic diversity found in old-growth forests over time, whether there is a consistent pattern of community assembly along succession, whether functional traits are phylogenetically conserved, and to what extent second-growth forests contribute to evolutionary history conservation at the landscape scale. Our results revealed that second-growth forests exhibit increasing species richness and phylogenetic diversity with forest age. However, standardized phylogenetic structure metrics (sesPD, sesMPD, sesMNTD) remained stable along succession and did not differ from old-growth forests, suggesting that successional time alone does not shape phylogenetic structure. Most functional traits showed low phylogenetic signal, indicating a decoupling between phylogenetic and functional recovery. Despite the absence of some rare and evolutionarily distinct lineages, particularly within Malpighiales, in second-growth forests, beta diversity analyses demonstrated that combining both forest types conserves a broader set of lineages than either type alone. This phylogenetic complementarity underscores the value of conserving both forest types as complementary components of regional biodiversity. Our findings emphasize the role of second-growth forests in preserving evolutionary history and support their inclusion in conservation and restoration strategies. By integrating broad-scale phylogenetic analyses with regional datasets, this study enhances our understanding of biodiversity recovery in one of the world's most threatened tropical biomes. • Second-growth forests recover phylogenetic diversity as they age • Phylogenetic structure remains stable across the successional gradient • Functional traits show weak phylogenetic signal in forest succession • Second-growth forests miss some rare, evolutionarily distinct lineages • Conserving both forest types maximizes evolutionary history across landscapesAlex Josélio Pires Coelho; Carlos M. Galván-Cisneros; Pedro Manuel Villa; Heitor Mancini Teixeira; Fábio Antônio Ribeiro Matos; Alice Cristina Rodrigues; Nayara Mesquita Mota; Fernando da Costa Britod Lacerda; Fábia Maria dos Santos Souza; Nathália Vieira Hissa Safar; Nathália Silva; Fabiana Bonani; Luiz Fernando Silva Magnago; Marcelo Simonelli; Carlos Ernesto Gonçalves Reynaud Schaefer; David P. Edwards; Markus Gastauer; Fernando Silla; Marinez Ferreira de Siqueira; João Augusto Alves Meira-Neto

Phylogenetic tree; Phylogenetic diversity; Biodiversity; Ecological succession; Species richness; Phylogenetics; Threatened species; Lineage (genetic); Ecology; Biology; Species diversity; Complementarity (molecular biology); Evolutionary biology; Community; Beta diversity; Ecosystem; Forest ecology

2026-03-03https://doi.org/10.1016/j.biocon.2026.111779Biological Conservation 20261Factors associated with the mini nutritional assessment–short form and its relationship to health outcomes after 4 years of follow-up: A longitudinal population-based studyLara Gabrielle Mendes de Assis; Giancarlo Lucchetti; F Bertocchi; Marise Machado de Oliveira; Maria Eduarda Duarte de Oliveira; Vívian Maria Gomes de Oliveira; Natália de Castro Pecci Maddalena; Alessandra Lamas Granero Lucchetti

Longitudinal study; Longitudinal data; MEDLINE; Cohort study; Medicine; Gerontology; Environmental health

2026-04-03https://doi.org/10.1016/j.gerinurse.2026.104012Geriatric Nursing 20261Percepção-em-ação no enjambementResumo A leitura do enjambement, usualmente descrito como um "desencontro" entre unidade sintática e padrão métrico fixado pela linha que limita o verso, envolve complexos processos cognitivos — percepção, reconhecimento de padrão, processamento de sentenças, antecipação, categorização. Para explicar esse fenômeno, os modelos se revezam entre versões mais ou menos internalistas — leitores de poesia versificada são processadores desincorporados, "sanduíches cognitivos" (cognitive sandwiches) do tipo input → processamento → output, livres de hábitos (culturais, físicos, sensório-motores), livres de artefatos sociotécnicos e de contextos. Interessa-nos aqui compreender como certas teses fundamentais do "externalismo cognitivo ativo", especialmente aquelas relacionadas à "percepção como ação", e à "cognição como predição", podem ajudar-nos a situar o enjambement no paradigma da cognição 4E (embodied, embedded, enacted, extended cognition)? Exploramos as implicações de certas premissas (4E) no domínio mais recente de discussão sobre a cognição estendida do verso e da quebra do verso.João Queiroz

Computer science; Business

2026-01-01https://doi.org/10.1590/01031813v65020268682850Trabalhos em Linguística Aplicada 20261Observation of structures in the <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"> <mml:mi>J</mml:mi> <mml:mo>/</mml:mo> <mml:mi>ψ</mml:mi> <mml:mo>+</mml:mo> <mml:mi>ψ</mml:mi> <mml:mo stretchy="false">(</mml:mo> <mml:mn>2</mml:mn> <mml:mi>S</mml:mi> <mml:mo stretchy="false">)</mml:mo> </mml:math> mass spectrum with the ATLAS detectorA search for resonant structures in the <a:math xmlns:a="http://www.w3.org/1998/Math/MathML" display="inline"> <a:mrow> <a:mi>J</a:mi> <a:mo>/</a:mo> <a:mi>ψ</a:mi> <a:mo>+</a:mo> <a:mi>ψ</a:mi> <a:mo stretchy="false">(</a:mo> <a:mn>2</a:mn> <a:mi mathvariant="normal">S</a:mi> <a:mo stretchy="false">)</a:mo> </a:mrow> </a:math> mass spectrum is performed using proton-proton collision data at <f:math xmlns:f="http://www.w3.org/1998/Math/MathML" display="inline"> <f:msqrt> <f:mi>s</f:mi> </f:msqrt> <f:mo>=</f:mo> <f:mn>13</f:mn> <f:mtext> </f:mtext> <f:mtext> </f:mtext> <f:mi>TeV</f:mi> </f:math> , corresponding to an integrated luminosity of <h:math xmlns:h="http://www.w3.org/1998/Math/MathML" display="inline"> <h:mn>140</h:mn> <h:mtext> </h:mtext> <h:mtext> </h:mtext> <h:msup> <h:mi>fb</h:mi> <h:mrow> <h:mo>−</h:mo> <h:mn>1</h:mn> </h:mrow> </h:msup> </h:math> , recorded by the ATLAS experiment at the LHC. The decay channels of <j:math xmlns:j="http://www.w3.org/1998/Math/MathML" display="inline"> <j:mi>J</j:mi> <j:mo>/</j:mo> <j:mi>ψ</j:mi> <j:mo>+</j:mo> <j:mi>ψ</j:mi> <j:mrow> <j:mo stretchy="false">(</j:mo> <j:mn>2</j:mn> <j:mi mathvariant="normal">S</j:mi> <j:mo stretchy="false">)</j:mo> </j:mrow> <j:mo stretchy="false">→</j:mo> <j:mn>4</j:mn> <j:mi>μ</j:mi> </j:math> and <p:math xmlns:p="http://www.w3.org/1998/Math/MathML" display="inline"> <p:mi>J</p:mi> <p:mo>/</p:mo> <p:mi>ψ</p:mi> <p:mo>+</p:mo> <p:mi>ψ</p:mi> <p:mrow> <p:mo stretchy="false">(</p:mo> <p:mn>2</p:mn> <p:mi mathvariant="normal">S</p:mi> <p:mo stretchy="false">)</p:mo> </p:mrow> <p:mo stretchy="false">→</p:mo> <p:mn>4</p:mn> <p:mi>μ</p:mi> <p:mo>+</p:mo> <p:mn>2</p:mn> <p:mi>π</p:mi> </p:math> are analyzed. An excess near 6.9 GeV is observed in both channels with a combined significance of <v:math xmlns:v="http://www.w3.org/1998/Math/MathML" display="inline"> <v:mrow> <v:mn>8.9</v:mn> <v:mi>σ</v:mi> </v:mrow> </v:math> . No significant signal is observed near 7.2 GeV, and an upper limit on its yield relative to <x:math xmlns:x="http://www.w3.org/1998/Math/MathML" display="inline"> <x:mi>X</x:mi> <x:mo stretchy="false">(</x:mo> <x:mn>6900</x:mn> <x:mo stretchy="false">)</x:mo> </x:math> is provided. A simultaneous fit with the di- <bb:math xmlns:bb="http://www.w3.org/1998/Math/MathML" display="inline"> <bb:mi>J</bb:mi> <bb:mo>/</bb:mo> <bb:mi>ψ</bb:mi> </bb:math> channel is carried out under assumptions regarding the resonance interferences, yielding a ratio of the partial decay widths between the <db:math xmlns:db="http://www.w3.org/1998/Math/MathML" display="inline"> <db:mi>J</db:mi> <db:mo>/</db:mo> <db:mi>ψ</db:mi> <db:mo>+</db:mo> <db:mi>ψ</db:mi> <db:mrow> <db:mo stretchy="false">(</db:mo> <db:mn>2</db:mn> <db:mi mathvariant="normal">S</db:mi> <db:mo stretchy="false">)</db:mo> </db:mrow> </db:math> and di- <ib:math xmlns:ib="http://www.w3.org/1998/Math/MathML" display="inline"> <ib:mi>J</ib:mi> <ib:mo>/</ib:mo> <ib:mi>ψ</ib:mi> </ib:math> channels of <kb:math xmlns:kb="http://www.w3.org/1998/Math/MathML" display="inline"> <kb:mn>1.08</kb:mn> <kb:mo>±</kb:mo> <kb:mn>0.2</kb:mn> <kb:msubsup> <kb:mn>0</kb:mn> <kb:mrow> <kb:mo>−</kb:mo> <kb:mn>0.17</kb:mn> </kb:mrow> <kb:mrow> <kb:mo>+</kb:mo> <kb:mn>0.40</kb:mn> </kb:mrow> </kb:msubsup> </kb:math> for the resonance near 6.9 GeV.G. Aad; E. Aakvaag; B. Abbott; S. Abdelhameed; K. Abeling; N. J. Abicht; S. H. Abidi; M. Aboelela; A. Aboulhorma; H. Abramowicz; Y. Abulaiti; B. S. Acharya; A. Ackermann; C. Adam Bourdarios; L. Adamczyk; S. V. Addepalli; M. J. Addison; J. Adelman; A. Adiguzel; T. Adye; A. A. Affolder; Y. Afik; M. N. Agaras; A. Aggarwal; C. Agheorghiesei; F. Ahmadov; S. Ahuja; S. Ahuja; X. Ai; G. Aielli; A. Aikot; M. Ait Tamlihat; B. Aitbenchikh; M. Akbiyik; T. P. A. Åkesson; A. V. Akimov; D. Akiyama; N. N. Akolkar; S. Aktas; G. L. Alberghi; J. Albert; U. Alberti; P. Albicocco; G. L. Albouy; S. Alderweireldt; Z. L. Alegria; M. Aleksa; I. N. Aleksandrov; C. Alexa; T. Alexopoulos; F. Alfonsi; M. Algren; M. Alhroob; B. Ali; H. M. J. Ali; S. Ali; S. W. Alibocus; M. Aliev; G. Alimonti; W. Alkakhi; C. Allaire; B. M. M. Allbrooke; D. R. Allen; J. S. Allen; J. F. Allen; P. P. Allport; A. Aloisio; F. Alonso; C. Alpigiani; Z. M. K. Alsolami; A. Alvarez Fernandez; M. Alves Cardoso; M. G. Alviggi; M. Aly; Y. Amaral Coutinho; A. Ambler; C. Amelung; M. Amerl; C. G. Ames; T. Amezza; D. Amidei; B. Amini; K. Amirie; A. Amirkhanov; S. P. Amor Dos Santos; K. R. Amos; D. Amperiadou; S. An; C. Anastopoulos; T. Andeen; J. K. Anders; A. C. Anderson; A. Andreazza; S. Angelidakis; A. Angerami; A. V. Anisenkov; A. Annovi; C. Antel; E. Antipov; M. Antonelli

Resonance (particle physics); Detector; Luminosity; Channel (broadcasting); Spectrum (functional analysis); Atlas (anatomy); Collision; Limit (mathematics); Physics; Optics; Nuclear physics; Yield (engineering); Mass spectrum; SIGNAL (programming language)

2026-04-28https://doi.org/10.1103/zhkx-k9zlPhysical review. D/Physical review. D. 20261Measurement of the top-quark Yukawa coupling from $$ t\overline{t} $$ production in the lepton+jets final state using pp collisions at $$ \sqrt{s}=13 $$ TeV with the ATLAS detectorA bstract The top-quark Yukawa coupling is extracted from the distribution of the top-quark pair ( $$ t\overline{t} $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mi>t</mml:mi> <mml:mover> <mml:mi>t</mml:mi> <mml:mo>¯</mml:mo> </mml:mover> </mml:math> ) invariant mass in proton-proton collisions using 140 fb − 1 of data at $$ \sqrt{s}=13 $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msqrt> <mml:mi>s</mml:mi> </mml:msqrt> <mml:mo>=</mml:mo> <mml:mn>13</mml:mn> </mml:math> TeV collected in 2015–2018 by the ATLAS experiment at the Large Hadron Collider. In the region near the production threshold, the $$ t\overline{t} $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mi>t</mml:mi> <mml:mover> <mml:mi>t</mml:mi> <mml:mo>¯</mml:mo> </mml:mover> </mml:math> invariant mass spectrum is sensitive to electroweak virtual corrections, including contributions from Higgs boson exchange, thereby providing sensitivity to the top-quark Yukawa coupling. This is the first measurement in ATLAS that aims to obtain this coupling exploiting this approach. The $$ t\overline{t} $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mi>t</mml:mi> <mml:mover> <mml:mi>t</mml:mi> <mml:mo>¯</mml:mo> </mml:mover> </mml:math> system is reconstructed in the single-lepton final state, requiring exactly one isolated electron or muon and at least four jets with at least two identified as originating from b -quarks. The measured Yukawa coupling is found to be in good agreement with the Standard Model prediction. An upper limit on the top-quark Yukawa coupling strength of Y t < 2 . 1 relative to the Standard Model prediction is observed at 95% confidence level, consistent with the expected sensitivity.G. Aad; E. Aakvaag; B. Abbott; S. Abdelhameed; K. Abeling; N. J. Abicht; S. H. Abidi; M. Aboelela; A. Aboulhorma; H. Abramowicz; Y. Abulaiti; B. S. Acharya; A. Ackermann; C. Adam Bourdarios; L. Adamczyk; S. V. Addepalli; M. J. Addison; J. Adelman; A. Adiguzel; T. Adye; A. A. Affolder; Y. Afik; M. N. Agaras; A. Aggarwal; C. Agheorghiesei; F. Ahmadov; S. Ahuja; S. Ahuja; X. Ai; G. Aielli; A. Aikot; M. Ait Tamlihat; B. Aitbenchikh; T. P. A. Åkesson; A. V. Akimov; D. Akiyama; N. N. Akolkar; S. Aktas; G. L. Alberghi; J. Albert; U. Alberti; P. Albicocco; G. L. Albouy; S. Alderweireldt; Z. L. Alegria; M. Aleksa; I. N. Aleksandrov; C. Alexa; T. Alexopoulos; F. Alfonsi; M. Algren; M. Alhroob; B. Ali; H. M. J. Ali; S. Ali; S. W. Alibocus; M. Aliev; G. Alimonti; W. Alkakhi; C. Allaire; B. M. M. Allbrooke; D. R. Allen; J. S. Allen; J. F. Allen; P. P. Allport; A. Aloisio; F. Alonso; C. Alpigiani; Z. M. K. Alsolami; A. Alvarez Fernandez; M. Alves Cardoso; M. G. Alviggi; M. Aly; Y. Amaral Coutinho; A. Ambler; C. Amelung; M. Amerl; C. G. Ames; T. Amezza; D. Amidei; B. Amini; K. Amirie; A. Amirkhanov; S. P. Amor Dos Santos; K. R. Amos; D. Amperiadou; S. An; C. Anastopoulos; T. Andeen; J. K. Anders; A. C. Anderson; A. Andreazza; S. Angelidakis; A. Angerami; A. V. Anisenkov; A. Annovi; C. Antel; E. Antipov; M. Antonelli; F. Anulli

Yukawa potential; Higgs boson; Electroweak interaction; Muon; Standard Model (mathematical formulation); Atlas (anatomy); Boson; Invariant mass; Physics; Particle physics; Nuclear physics; Atlas detector; Large Hadron Collider; Hadron; Coupling (piping); Elementary particle; Pair production; Physics beyond the Standard Model; ATLAS experiment; Invariant (physics); Coupling constant

2026-01-19https://doi.org/10.1007/jhep01(2026)117Journal of High Energy Physics 20261Towards intelligent air quality forecasting using integrated machine learning framework with variational mode decomposition and catboost feature selectionAbstract Predicting air pollution is crucial in improving air quality (AQ), which consequently provides benefits to the ecosystems and human health. AQ predictions often make use of Machine Learning (ML) approaches; nevertheless, these methods are not without their limitations. The main contribution of this research is to develop an efficient framework using machine learning (ML) for forecasting daily air quality metrics for Sulfur dioxide (SO 2 ) and Nitrogen dioxide (NO 2 ) in Changping, China. The suggested ML method is based on a set of local weights and a kernel extreme learning machine (LWKELM) model integrated with an efficient feature selection, the Catboost method, to extract influential input variables. Additionally, the input variables, collected from 2013 to 2017, are decomposed using multivariate variational mode decomposition (MVMD), which enhanced the predicting accuracy. Furthermore, the interior search algorithm (ISA), a robust optimization strategy, is a possible way of optimizing the models’ hyperparameters. The results of the developed model was compared with the four other reliable ML approaches, including the locally weighted linear regression (LWLR), gaussian process regression (GPR), KELM, and multivariate adaptive regression spline (MARS) models. Based on the results, the proposed model demonstrates superior performance across statistical metrics for both parameters (NO₂: R = 0.978, RMSE = 0.537 and SO₂: R = 0.974, RMSE = 1.965) compared to alternative models. The MVMD-LWKELM-ISA model delivers highly accurate one-day-ahead forecasts for SO 2 and NO 2 and stands out as the most effective and intelligent approach for forecasting these daily parameters.Iman Ahmadianfar; Zaher Mundher Yaseen; Haydar Abdulameer Marhoon; Bijay Halder; Mou Leong Tan; Huseyin Cagan Kilinc; Sani I. Abba; Salim Heddam; Leonardo Goliatt; Vahdettin Demir; Ahmed M. Al-Areeq

Feature selection; Air quality index; Kriging; Multivariate statistics; Mean squared error; Extreme learning machine; Gaussian process; Feature (linguistics); Kernel (algebra); Multivariate adaptive regression splines; Machine learning; Computer science; Artificial intelligence; Data mining; Regression; Model selection; Mode (computer interface); Process (computing); Decomposition; Linear regression; Selection (genetic algorithm); Regression analysis

2026-01-02https://doi.org/10.1038/s41598-025-33785-yScientific Reports 20261Iterated Greedy Algorithm for Vehicle Routing Problem With Parcel LockersThe growth in e-commerce sales has been constant and, driven by the Covid-19 pandemic, has exceeded previous expectations. Owing to social isolation, parcel lockers - systems for goods collection - have become widely used to reduce physical contact between people involved in the delivery process. This resource has also become an important strategy for reducing costs, as it enables deliveries from multiple customers to be consolidated in the same location. In the context of smart cities, in which the optimization of urban transport plays a key role in building more sustainable and efficient environments, the inclusion of parcel lockers is essential. Thus, research in this area that considers their use aligns with the concept of smart cities, promoting the use of innovative technologies to improve mobility and urban logistics. Specifically in this context, the Vehicle Routing Problem With Parcel Lockers (VRPPL) is an extension of the Vehicle Routing Problem with TimeWindows (VRPTW), introducing the use of lockers, with the objective to reduce the total distance traveled. In this study, an algorithm based on Iterated Greedy (IG) and Random Variable Neighborhood Descent (RVND) was developed to reduce the costs and computational times presented in the literature. We selected a set of 168 well-known instances for the problem. Computational experiments and comparative analyses were performed. The developed algorithm achieved better results in 167 instances, with an average gap of −1.315%. The best execution times were obtained for all instances, thereby reducing the mean execution time from 240.293s to 0.104s.Rafael Freesz Resende Corrêa; Stênio Sã Rosário Furtado Soares; Luciana Brugiolo Gonçalves; Lorenza L. O. Moreno

Vehicle routing problem; Iterated local search; Greedy algorithm; Context (archaeology); Routing (electronic design automation); Key (lock); Variable (mathematics); Variable neighborhood search; Computer science; Mathematical optimization; Resource (disambiguation); Operations research; Set (abstract data type); Metaheuristic; City logistics; Smart city

2026-01-01https://doi.org/10.1109/access.2025.3650745IEEE Access 20261Barrow black hole variable parameter model and information theoryÉverton M. C. Abreu; Jorge Ananias Neto

Event horizon; Entropy (arrow of time); Black hole information paradox; Information theory; Fractal; Variable (mathematics); Black hole (networking); Event (particle physics); Physics; Statistical physics; Constant (computer programming); Computation; Function (biology); Horizon; Theoretical physics; Energy (signal processing); Quantum; Relation (database); Mathematics

2026-01-07https://doi.org/10.1140/epjp/s13360-025-07168-1The European Physical Journal Plus 20261ITGA4 genetic variants as a predictor of therapeutic responsivity to autoimmune diseasesIntegrins are pivotal adhesion receptors that mediate dynamic communication between cells and their surrounding environment. Through bidirectional signaling, they regulate key physiological processes such as cell migration, inflammation, and tissue organization. Among them, the α4 integrin subunit, encoded by the ITGA4 gene, forms α4β1 (VLA-4) and α4β7 heterodimers, both essential for leukocyte adhesion and migration across inflamed tissues and blood–brain barrier. Variability in therapeutic response to α4 integrin inhibitors, such natalizumab, highlights the need to clarify the genetic and molecular determinants that regulate ITGA4 function. This mini review provides an updated overview of ITGA4 from historical, biological, and pharmacogenetic perspectives. We summarize current evidence linking ITGA4 genetic variants with disease susceptibility, progression, and therapeutic outcomes in autoimmune and neuroinflammatory disorders. Finally, we discuss existing limitations, population inconsistencies, and emerging strategies integrating multi-omic and in silico analyses to translate ITGA4 variants into predictive biomarkers for personalized immunotherapy.Matheus Dumans de Matos; Bárbara Dahmer Guimenes; Giovanni K. Pavani; Gabriel Gripp Fernandes; Guilherme Carneiro Montes; Fabrícia L. Fontes-Dantas

Integrin; Genetic variants; Pharmacogenetics; Cell adhesion; Population; Cell adhesion molecule; Disease; Autoimmune disease; Medicine; Immunology; Receptor; Bioinformatics; Biology; Computational biology; Personalized medicine; Cell

2026-01-08https://doi.org/10.3389/fphar.2025.1745315Frontiers in Pharmacology 20261Ischemic preconditioning with active reperfusion does not improve high-intensity intermittent exercise in youth team sport playersPURPOSE: We investigated whether an active protocol of ischemic preconditioning (IPC-A) would improve high-intensity intermittent exercise performance in youth team sport players. METHODS: Fifteen male amateur team sport players (15.5 ± 0.5 yrs) attended four different preconditioning sessions before the YoYo Intermittent Recovery Test level 1 (YYIR1) interspersed by seven days in a counterbalanced randomized cross-over design. IPC protocol consisted of three cycles of 5 min occlusion (220 mmHg) and 5 min reperfusion (0 mmHg) in both thighs. SHAM was similar to the IPC protocol, but 'occlusion' pressure was set up at 20 mmHg. Active protocols (IPC-A/ SHAM-A) were similar to the IPC/SHAM, but participants exercised (intermittent run) during the 'reperfusion' phases instead of resting. Six minutes after the protocol, the participants performed the YYIR1. RESULTS: The distance covered in the YYIR1 did not differ (p = 0.46) among the protocols: IPC (917 ± 204 m) vs. IPC-A (931 ± 211 m) vs. SHAM (968 ± 201 m) vs. SHAM-A (933 ± 204 m). Blood lactate concentration, and mean heart rate did not differ either (p > 0.05) among the protocols. CONCLUSIONS: Active ischemic preconditioning involving exercise during reperfusion phase does not improve high-intensity intermittent exercise performance nor alter physiological or perceptual responses in youth team sport players.Gustavo Ribeiro Da Mota; Izabela A. Santos; Anderson Luiz Rodrigues; Bernardo Neme Ide; Tom Citherlet; Jeffer E. Sasaki; Moacir Marocolo

Ischemic preconditioning; Sports medicine; Team sport; Human physiology; Physical activity; Physical exercise; Medicine; Physical therapy; Physical medicine and rehabilitation; Perception

2026-01-12https://doi.org/10.1007/s00421-025-06103-7European Journal of Applied Physiology 20261Prevention of renal and genital leptospirosis in experimentally infected ewes by vaccinationJuliana Loria; Camila Ezepha; Isabel Roussouliéres; Guilherme Nunes de Souza; Florencia Sardi; P. Alonzo; W. Lilenbaum

Leptospirosis; Vaccination; Direct agglutination test; Serotype; Leptospira; Urine; Immunization; Sex organ; Medicine; Immunology; Virology; Genitourinary system; Antibody; Physiology; Immunity; Transmission (telecommunications); Leptospira interrogans; Cervix; Kidney

2026-01-14https://doi.org/10.1016/j.nexres.2026.101348Next research. 20261Ecological Processes Shaping Marine Microbial Assemblages Diverge Between Equatorial and Temperate Time‐SeriesMarine microbial communities are structured by a complex interplay of deterministic and stochastic processes, yet how these vary across latitudes remains poorly understood. Most long-term microbial observatories are restricted to temperate regions, limiting our ability to assess latitudinal contrasts in microbial dynamics. Here, we compare coastal microbial communities from two contrasting marine time-series stations using standardised molecular protocols: a new tropical site in the Equatorial Atlantic (EAMO, 6° S) and a well-studied temperate site in the Mediterranean Sea (BBMO, 41° N). Monthly 16S and 18S rRNA gene sequencing of two size-fractions (0.22-3 μm and > 3 μm) over 41 months (from April 2013 to August 2016) revealed marked differences in taxonomic composition, temporal variability and ecological assembly processes. Temperate communities exhibited strong seasonal turnover, higher beta-diversity and tighter coupling with environmental variables such as temperature and daylength. In contrast, tropical communities were compositionally more stable and more governed by biotic factors and stochastic processes such as historical contingency and ecological drift. These patterns were consistent across taxonomic domains and size-fractions, though selection was generally stronger in prokaryotes and the smallest size-fraction. Co-occurrence networks at the temperate site were more densely connected and environmentally responsive compared to tropical networks, where stochastic processes and putative biological interactions gain prominence. This study highlights the importance of integrating observatories from underrepresented latitudes into global microbial monitoring efforts, particularly as climate change alters the amplitude and frequency of environmental drivers across the ocean.Pedro C. Junger; Vinicius Kavagutti; Ina Maria Deutschmann; Carlota R. Gazulla; Paula Huber; Maiara Menezes; Rodolfo Paranhos; André Megali Amado; Isabel Ferrera; Janaina Rigonato; Samuel Chaffron; Josep M. Gasol; Ramiro Logares; Hugo Sarmento

Temperate climate; Mediterranean climate; Taxon; Latitude; Subtropics; Environmental change; Climate change; Mediterranean sea; Tropics; Ecology; Biology; Community structure; Microbial population biology; Limiting; Global change; Tropical climate; Taxonomic rank

2026-01-01https://doi.org/10.1111/mec.70241Molecular Ecology 20261Optimizing Balantioides coli in vitro maintenance: effects of temperature and lipid supplementation in modified Pavlova mediumBACKGROUND: Balantioides coli is a ciliated protozoan whose main hosts include pigs, non-human primates, and humans. Balantidiasis is a zoonotic disease capable of causing clinical dysentery in both animals and humans. Laboratory diagnosis is traditionally based on microscopic parasitological techniques, and only a few studies have explored in vitro culture for parasite isolation and maintenance, mainly due to its labor-intensive routine. METHODS: This study aimed to evaluate the maintenance and growth performance of B. coli in modified Pavlova medium supplemented with different lipid sources under varying temperatures and incubation times. Between February and April 2025, a B. coli strain previously isolated from pig feces and maintained in the laboratory was analyzed. A standard inoculum of 500 trophozoites was transferred into culture tubes containing Pavlova medium prepared under four conditions: without serum (P0), supplemented with coconut water (PC), fetal bovine serum (PB), or equine serum (PE). Cultures were incubated at five temperatures (32, 34, 36, 38, and 40 °C) and assessed at four time points (24, 48, 72, and 96 h). Growth was quantified as trophozoites per mL. RESULTS: The highest B. coli counts occurred in media containing fetal bovine (PB) and equine (PE) serum, particularly in PE at 40 °C for 48 h. Coconut-water medium (PC) showed only a mild increase at 36–38 °C after 72–96 h, whereas the control (P0) supported limited growth. Significant differences (p < 0.05) were observed among media types, incubation periods, and temperatures, except between PB and PE at 32–36 °C. CONCLUSIONS: Modified Pavlova medium supplemented with fetal bovine or equine serum, particularly under incubation at 38–40 °C, provided the most favorable conditions for B. coli growth and maintenance. This study provides, for the first time, a systematic evaluation of lipid supplementation and incubation conditions, establishing standardized parameters for the routine laboratory cultivation of this zoonotic ciliate.Camila Souza Carvalho Class; Renan de Souza Ferreira; Ingrid da Silva Reis; Laís Lisboa Corrêa; Breno Torres da Silva; José Arcínio de Assis; Gabriella Ribeiro Vaz da Costa; Fabiana Batalha Knackfuss; Roberto Júnio Pedroso Dias; Alynne Da Silva Barbosa

Incubation; Fetal bovine serum; Feces; In vitro; Incubation period; Parasite hosting; Microbiology; Biology; Food science; Escherichia coli; Isolation (microbiology); Growth medium; Bacteria; Strain (injury); Veterinary medicine

2026-01-16https://doi.org/10.1186/s12917-025-05282-xBMC Veterinary Research 20261Mechanical Stability and Binder Interaction in MOF Composites: An Integrated Experimental and DFT StudyAn integrated study combining experimental methods and DFT simulations was undertaken to investigate the binder/MOF composites. The findings demonstrate a strong correlation between the crush strength and surface adsorption energy of methylcellulose (MC) on HKUST, ZIF-8, UiO-66-(Zr), and MIL-53-(Al)-TDC surfaces. Experimental thermogravimetric data and compressive strength measurements, combined with simulated adsorption energies, bond distances, and charge distributions, supported this relationship. DFT calculations of adsorption energy and structural analysis showed that MC/HKUST and MC/ZIF-8 composites exhibit stronger interactions with MC, consistent with their higher mechanical strength at higher temperatures. In contrast, MC/UiO-66-(Zr) and MC/MIL-53-(Al)-TDC presented weaker interactions and lower resistance under thermal stress. This study demonstrates that computational methods, when integrated with experimental techniques, can offer valuable insights into the design of mechanically stable binder/MOF composites.F M C Silva; Mateus A. M. Paiva; Inna M. Nangoi; Maria Eduarda T. Lima; Talita V. F. da Silva; Leonã S. Flôres; Raphael B. Menezes; Charlane C. Corrêa; Alexandre A. Leitão

Thermogravimetric analysis; Adsorption; Thermal stability; Structural stability; Density functional theory; Stability (learning theory); Compressive strength; Thermal; Materials science; Composite material; Thermodynamics; Molecular dynamics; Energy (signal processing); Mechanical strength; Bond strength; Surface energy; Chemical engineering

2026-01-26https://doi.org/10.1021/acsomega.5c09981ACS Omega 20261Psychological and hematological factors associated with fatigue in patients with Crohn’s disease receiving pharmacological treatmentBACKGROUND Fatigue is debilitating and costly for patients with Crohn’s disease (CD) and the healthcare system. Thus, as there are no well-established therapies for fatigue in patients with CD, it is essential to investigate its risk factors and collaborate to prevent or reduce its burden. AIM To evaluate the variables associated with fatigue in outpatients with CD receiving pharmacological treatment. METHODS It is an observational study. Data, including sociodemographic information, inflammatory bowel disease fatigue scores, visual analog scale scores, Depression Anxiety Stress Scale-21 scores, insomnia assessment results, and laboratory test results, were collected. Statistical analyses included Student’s t tests, logistic and linear regressions, and receiver operating characteristic curve analysis, with a P value of < 0.05 indicating statistical significance. RESULTS One hundred patients were included (77% presented with fatigue). In the linear regression analysis, symptoms of depression, anxiety, stress, and insomnia were simultaneously included as predictors of fatigue. Although the model was statistically significant (adjusted R 2 = 0.128; P = 0.002), no single symptom was significantly associated. A composite score (0-4) was developed by summing the scores of the 4 symptoms, which were coded dichotomously (odds ratio = 2.60; 95% confidence interval: 1.61-4.83; P < 0.001). The composite score showed good discriminative capacity (area under the curve = 0.775). Patients with fatigue had higher total leukocyte (P = 0.034) and segmented neutrophil (P = 0.017) counts and lower lymphocyte (P = 0.019) and eosinophil (P = 0.036) counts. Effect sizes ranged from moderate to high (Cohen’s d 0.39-0.61), indicating that fatigue may be associated with a leukocyte pattern consistent with relative neutrophilia and lymphopenia. CONCLUSION Fatigue is associated with psychological symptoms, a sedentary lifestyle, and alterations in leukocyte subpopulations. Assessments incorporating composite symptom scales and hematological parameters may be practical and cost-effective for patients with fatigue.Tayane C Morais; Genalva Couto; Bruno Rafael Costa Venâncio da Silva; Raísa A Lisbôa; Bruna S da Cruz; Maria G F Viana; Gabriela B C de Sousa; Lara P Arenas; Erick S Nery; Flora Maria Lorenzo Fortes; Neogélia Pereira de Almeida; Andréa Maia Pimentel; Jaciane Araújo Mota Fontes; Valdiana Cristina Surlo; Julio Fonseca Chebli; Raquel Rocha; Genoile Oliveira Santana

Disease; Depression (economics); Severity of illness; Anemia; MEDLINE; Quality of life (healthcare); Medicine; Internal medicine; Physical therapy; Immunology

2026-01-27https://doi.org/10.3748/wjg.v32.i5.115673World Journal of Gastroenterology 20261High Mental Fatigue Magnitude Generates Greater Impaired Resistance Exercise Performance Than Moderate Mental Fatigue Magnitude in Trained AdultsABSTRACT Mental fatigue (MF) has been widely investigated in resistance exercise (RE). However, the results remain inconsistent, likely due to variability in the cognitive load across studies and, most importantly, the lack of individualized assessments of self‐reported MF levels among participants before initiating the RE session. Therefore, the present study aimed to analyze the acute effect of different levels of MF induced by prior cognitive effort on the subsequent number of repetitions performed during an RE session. In a crossover trial, 20 participants were randomly assigned to three experimental conditions: a control and two mentally fatiguing conditions. In the MF conditions, the participants performed a computerized Stroop word‐color (ST) task until reaching 40 mm (moderate MF) and 80 mm (high MF) on the visual analog scale for MF. Following all three conditions, participants completed an RE session consisting of six sets of half back‐squat performed to muscle failure with a fixed load of ∼45% 1RM (1.0 m.s −1 ). Physical and perceptual parameters—including total repetitions, repetitions per set, repetitions per velocity loss, and rating of perceived exertion (RPE)—were measured during the RE session. Participants exhibited a lower number of repetitions and a higher RPE during RE in the high MF condition compared to the moderate MF and control conditions, with a significant difference also observed between the moderate MF and control conditions ( p < 0.05). In summary, these findings suggest that a high level of subjective MF results in a greater magnitude of impairment in physical performance during an RE session.Siqueira Júnior; Dalton de Lima‐Junior; Fábio Yuzo Nakamura; Maria Elisa Caputo Ferreira; Leonardo de Sousa Fortes

Stroop effect; Mental fatigue; Rating of perceived exertion; Crossover study; Cognition; Resistance training; Perceived exertion; Muscle fatigue; Medicine; Physical medicine and rehabilitation; Physical therapy; Audiology; Psychology; Visual analogue scale; Chronic fatigue syndrome; Rating scale; Perception

2026-01-29https://doi.org/10.1002/ejsc.70128European Journal of Sport Science 20261VIOLÊNCIA PATRIMONIALAnalisa-se as produções existentes sobre a Violência Patrimonial (VP), com intuito de descrever sobre o que os estudos abordam. Realizou-se revisão integrativa de artigos nas bases de dados: Dialnet, PsycINFO, SciELO, Scopus e Web of Science; período 2015-2021. Buscou-se os descritores “violência patrimonial”, “abuso econômico”, “abuso financeiro” separadamente em português, inglês e espanhol. Resultados identificam 37 artigos, desenvolvidos em 9 países, com análise categórica de 6 categorias. Verificou-se que há: percepção dos atos de VP, mas pouca compreensão; ocorrência não isolada de outras violências; dificuldade em sair da vivência com perpetrador; estratégias utilizadas para proteção de dinheiro/bens; saúde mental agravada pela VP; inaptidão do Estado para intervenções eficazes. Percebe-se pouca literatura sobre essa violência interpessoal na América Latina, havendo diversidade sobre o assunto, sendo necessário mais estudos para compreensão ampla e planejamento de intervenções.Andressa Helena Quirino; Felipe Almeida Dias Mendes; Lelio Lourenço

Flavobacteriaceae; Web site; SciELO; Humanities; Geography

2026-02-03https://doi.org/10.31060/rbsp.2026.v20.n1.2068Revista Brasileira de Segurança Pública 20261Evidence synthesis methodology for questions relating to barriers and enablers in health care: a scoping reviewOBJECTIVE: The objective of this scoping review was to map the range of methodologies and methods used to undertake evidence synthesis aimed at determining barriers and/or enablers in health care, and to inform further research relevant to synthesis methodology in this area. INTRODUCTION: Questions related to identifying and exploring barriers and/or enablers within health care are becoming increasingly popular. Currently, there are multiple approaches to synthesizing this evidence, and it is unclear whether a more consistent approach is warranted. ELIGIBILITY CRITERIA: Evidence synthesis on barriers and/or enablers (facilitators) that included interest-holders at different levels of the health system were considered. Evidence synthesis projects had to include primary research studies and were published from 2010 to 2021. Literature reviews, narrative reviews, and umbrella reviews were excluded, as were reviews published in languages other than English. METHODS: This scoping review followed JBI methodology and was based on a published a priori protocol and reported in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR). A 3-step search strategy using a combination of key terms and index headings was undertaken in October 2021 via the following databases/resources: PubMed, Embase, CINAHL (EBSCOhost), PsycINFO (Ovid), Cochrane Database of Systematic Reviews, JBI Evidence Synthesis , and EPPI-Centre Systematic Reviews. An extensive piloting process for screening and selection, and data extraction was undertaken due to the large number of reviewers involved. All records were screened independently by 2 reviewers, and any disagreements were resolved through either a third reviewer or discussion with a panel of reviewers. Extraction was undertaken using a customized form, and data were analyzed using descriptive statistics. Data are presented via tables, figures, a word cloud, and an infographic, supplemented with a narrative synthesis. RESULTS: Following completion of the search, 24,823 records were screened and 774 reviews were included in the scoping review. Systematic reviews were the most commonly used methodology (68%) to synthesize barrier and/or enabler questions. Reviews often included diverse types of evidence and involved an assessment of methodological quality (70%). Findings related to barriers and/or enablers were usually grouped and organized into categories, often by thematic methods (33%) or a narrative approach (20%). Incongruencies related to nomenclature, missing information, and methods used were evident across the large dataset. CONCLUSIONS: A variety of methodological approaches are being followed to undertake reviews focused on barriers and/or enablers in health care. The current state of the literature indicates that most authors answer these questions via the conduct of a systematic review and include diverse types of evidence. Further work is needed to determine whether authors are unclear when deciding on methodology and whether guidance is required.Cindy D. Stern; Chelsea Valenzuela; Ashley Whitehorn; Danielle Pollock; Sonia Minooee; Dilan Arun Gohil; Zheng Zhu; Pamela Kirkpatrick; Ricardo L. Loureiro; Ellen Davies; Daniela Cardoso; Zachary Munn; Judith Carrier; Dawid Bühn Pieper; K Cooper; Romy Menghao Jia; Heather Loveday; Priya Martin; Susan Salmond; Kelli Borges dos Santos; Nahal Habibi; Lucylynn Lizarondo

Variety (cybernetics); Systematic review; Work (physics); MEDLINE; State (computer science); Engineering ethics; Management science; Knowledge management; Psychology; Medicine

2026-02-03https://doi.org/10.11124/jbies-25-00265JBI Evidence Synthesis 20261Reflection positivity in a higher-derivative model with physical bound states of ghostsA bstract The inclusion of higher derivatives is a necessary condition for a renormalizable or superrenormalizable local theory of quantum gravity. On the other hand, higher derivatives lead to classical instabilities and a loss of unitarity at the quantum level. A standard way to detect such issues is by examining the reflection positivity condition and the existence of a Källén-Lehmann spectral representation for the two-point function. We demonstrate that these requirements for a consistent quantum theory are satisfied in a theory we have recently proposed. This theory is based on a six-derivative scalar field action featuring a pair of complex-mass ghost fields that form a bound state. Our results support the interpretation that physical observables can emerge from ghost dynamics in a consistent and unitary framework.M. Asorey; G. Krein; Miguel Pardina; I. L. Shapiro

Unitarity; Observable; Quantum field theory; Unitary state; Scalar (mathematics); Interpretation (philosophy); Quantum; Reflection (computer programming); Scalar field theory; Physics; Theoretical physics; Quantum mechanics; Field (mathematics); Bound state; Action (physics); Field theory (psychology); Scalar field; Quantum gravity; Representation (politics); Thermal quantum field theory; S-matrix; Mathematical physics; Classical mechanics; Unitary representation

2026-02-02https://doi.org/10.1007/jhep02(2026)020Journal of High Energy Physics 20261A combined in situ–ex situ assessment of fish feed fate and associated carbon emissionsAquaculture plays a key role in addressing the global protein demand. However, its long-term sustainability depends on minimizing its environmental impacts, particularly eutrophication and greenhouse gas (GHG) emissions. The fate of fish feed that is not ingested by the fish remains an overlooked factor, yet it is crucial for accurately assessing the carbon footprint of fish production. To assess the fate of undigested fish feed under different conditions, we used complementary in situ and ex situ approaches to separate the effect of feed composition from the influence of pond conditions. First, we performed an in situ experiment to investigate the breakdown of four common fish feed types, and secondly, quantified their associated carbon dioxide (CO 2 ) and methane (CH 4 ) production in an ex situ experiment. We explored potential drivers, including feed physicochemical properties. Results showed that the feeds varied significantly in their properties (CN ratio range: 5.4–10.7; decay constant k range: 0.023–0.05 h −1 ). This variation was critical: feeds with lower physical stability and lower CN ratios disintegrated fastest. In ex situ incubations, CO 2 production significantly increased with the addition of all feed types compared to controls that contained only fishpond sediment (±15 nmol g −1 h −1 ). Conversely, CH 4 production was minimal across all treatments even under anoxic conditions. Our findings indicate that while feed decomposition directly stimulated CO 2 production, it did not constitute a determining factorin CH 4 production in this system. Critically, we show that feed physicochemical properties, particularly physical stability and CN ratio, are key regulators of the rate of these microbial processes. To effectively reduce aquaculture's carbon footprint, future development must embed precision feeding (i.e. prevention of overfeeding), along with improved feed composition and stability, into comprehensive GHG mitigation strategies. • Methane (CH 4 ) emissions from fish feed are negligible under both oxic and anoxic conditions. • Rapid feed decomposition reveals its key role in carbon cycling within aquaculture systems. • Feed addition increases CO 2 flux, but emissions do not reflect net greenhouse gas input. • High-protein feeds (low C:N) degrade faster and alter tank biogeochemistry. • Feed-derived carbon is rapidly mineralized, highlighting the importance of feed composition in aquaculture assessments.Laís Coura Soranço; Gabrielle Rabelo Quadra; Jesper Wien; Ana Paula Dalbem Barbosa; Anderson Machado de Melo Júnior; Giovana Machado Cardoso; Vitor Luís da Cunha Duque; Caique Rodrigues Soares; Tarcila Souza de Castro Silva; Giovanni Resende de Oliveira; Sarian Kosten; Nathan Barros

Anoxic waters; Eutrophication; In situ; Greenhouse gas; Carbon dioxide; Aquaculture; Carbon fibers; Methane; Environmental science; Environmental chemistry; Chemistry; Fish <Actinopterygii>; Carbon footprint; Environmental engineering; Carbon sequestration; Composition (language); Contamination; Commercial fish feed

2026-02-01https://doi.org/10.1016/j.jclepro.2026.147711Journal of Cleaner Production 20261Survival of Customized Subperiosteal Implants in Atrophic MaxillaABSTRACT Rehabilitation of edentulous patients with severe bone atrophy is challenging, as limited bone availability often precludes conventional implants. In such cases, 3D-printed customized subperiosteal prostheses offer a precise, less invasive alternative to bone grafting, though potential postoperative complications may affect treatment success. This study aimed to describe survival in patients rehabilitated with customized subperiosteal prostheses in the maxilla. A case series was conducted in patients with maxillary bone atrophy treated with customized subperiosteal prostheses and a minimum follow-up of 1 year. Patients with uncontrolled systemic comorbidities, ablative surgery, oncologic treatment, or incomplete medical records were excluded. Statistical analysis was performed using GraphPad Prism 10.5.0, applying the ShapiroWilk test, Spearmans coefficient, and a significance level of p < 0.05. Eight patients were included (six women and two men) with a mean age of 63.75 ± 6.6 years (range 5572). A total of 16 partial subperiosteal prostheses were placed in the maxilla. Three postoperative complications were recorded: two cases of vestibular exposure of the framework and one case of a closed oroantral fistula. The female sex was significantly associated with a higher frequency of postoperative complications (p = 0.003), whereas no significant differences were found regarding age (p = 0.8). The mean follow-up period was 20.12 ± 10.0 months, and patient satisfaction, as measured by the Visual Analog Scale (VAS), was 8.4 ± 1.3. Mucosal grafts were performed to manage soft tissue exposures; however, one prosthesis was removed due to persistent exposure. No significant correlation was found between the occurrence of complications and prosthesis removal (p = 0.2). Within the limitations of this study, customized subperiosteal prostheses demonstrated favorable stability and high patient satisfaction, with a low incidence of complications during follow-up.Víctor Ravelo; Jose Valdivia; Joel Joshi Otero; Henrique Duque; Roberto Sacco; Sergio Adrian Olate

Prosthesis; Soft tissue; Atrophy; Maxilla; Bone remodeling; Visual analogue scale; Medical record; Medicine; Dentistry; Surgery; Dental prosthesis; Statistical analysis; Statistical significance

2026-01-24https://doi.org/10.1563/aaid-joi-d-25-00215Journal of Oral Implantology 20261AuNPs@Al-TDC Metal–Organic Framework: A Hybrid Nanostructure for 3D-Printed Electrochemical Sensors Targeting DiuronHigh Resolution Image Download MS PowerPoint Slide The integration of sustainability principles, green chemistry, and circular economy concepts enables the recycling of polymers such as acrylonitrile-butadiene-styrene (ABS) into innovative and functional devices. In this context, advances in composite materials and conductive filaments are essential for the development of inexpensive and sustainable electrochemical sensors. This study presents a sensor (AuNPs@Al-TDC/3D-CPE) fabricated via 3D printing using recycled ABS filaments, modified with the Al-TDC metal–organic framework (MOF) and gold nanoparticles (AuNPs). The MOF composite was synthesized from tetrachloroauric acid, thiophene-2,5-dicarboxylic acid, dimethylformamide, and formic acid under microwave-assisted hydrothermal conditions, and in a postsynthesis modification, the AuNPs were incorporated. The hybrid materials underwent a comprehensive physicochemical evaluation through spectroscopic, imaging, and electrochemical approaches, confirming both the successful incorporation of the modifiers and the structural integrity of the sensing platform. For its analytical application, the pesticide Diuron was selected as the target molecule for the development of a differential pulse voltammetry (DPV) protocol, whose procedure was systematically optimized using the AuNPs@Al-TDC/3D-CPE. The sensor exhibited a well-defined linear dynamic range between 1.0 and 20.0 μmol L –1, achieving a detection limit of 0.040 μmol L –1 . Precision was confirmed by relative standard deviations consistently below 7%. Accuracy was further validated through recovery assays in fortified water samples, yielding values between 97% and 105%. The proposed sensor is efficient, cost-effective, and environmentally friendly, representing a promising alternative for the monitoring of emerging contaminants in alignment with the sustainable development goals.Raylla Santos Oliveira; Hudson Batista Da Silva; Esther de Jorge Duarte; Cassiano Cunha de Souza; Wallace Burger Veríssimo de Oliveira; Charlane C. Corrêa; Gustavo Fernandes Souza Andrade; Maria Auxiliadora Costa Matos; Thalles Pedrosa Lisboa; Renato Camargo Matos

Differential pulse voltammetry; Detection limit; Electrochemistry; Formic acid; Nanostructure; Electrochemical gas sensor; Hydrothermal circulation; Composite number; Materials science; Nanotechnology; Nanocomposite; Cyclic voltammetry; Nanoparticle; Linear range; Colloidal gold

2026-02-11https://doi.org/10.1021/acsomega.5c11545ACS Omega 20261Training, Experience, and Attitudes of Dental Students About Oral Biopsies: A Multicenter Cross‐Sectional Study in Latin AmericaOBJECTIVE: To evaluate the training, clinical experience, and attitudes related to oral biopsy among dental students from Latin America. MATERIALS AND METHODS: The study included 326 final-year dental students from universities in Argentina, Brazil, Colombia, Mexico, and Venezuela. Participants completed a structured, anonymous 35-item online questionnaire addressing demographic data, exposure to oral biopsy procedures, self-perceived knowledge and skills, and attitudes towards biopsy practice. Data were analyzed using descriptive statistics, Fisher's exact test, and the Wilcoxon test, with a significance level of 5%. RESULTS: Most students reported having received formal theoretical training in oral biopsy (89.9%). Only 53.4% had performed at least one biopsy during their undergraduate studies, with excisional biopsies being the most common. Despite a high level of agreement regarding the relevance of oral biopsy to clinical practice (p < 0.001), students demonstrated low self-confidence in performing incisional and excisional biopsies (p < 0.001 for both), particularly in lesions suspected of malignancy (p < 0.001). Prior practical experience was significantly associated with higher levels of confidence and more favorable attitudes towards performing biopsies (p < 0.001). CONCLUSION: Oral biopsy training among Latin American dental students is heterogeneous and largely theoretical, with limited practical experience contributing to reduced diagnostic autonomy and clinical confidence.Marcos Paulo Maia‐Lima; Luiz Miguel Ferreira; Fabrício Emanuel Soares de Oliveira; Tarcília Aparecida da Silva; Beatriz Rezende Bergo; Estela Kaminagakura; Bruno Augusto Benevenuto de Andrade; Paulo Rogério Ferreti Bonan; Fabrício Tinôco Alvim de Souza; MáRCIO CAMPOS OLIVEIRA; Mariana Villarroel‐Dorrego; Any Sánchez‐Mendez; Gerardo Gilligan; Claudia Patricia Peña Vega; Andrés Rueda Jiménez; Ricardo Martinez‐Pedraza; Hercílio Martelli‐Júnior

Latin Americans; Autonomy; Multicenter study; Dental education; Oral and maxillofacial pathology; Clinical trial; Medicine; Family medicine; Medical education; Dentistry; MEDLINE; Oral health

2026-02-12https://doi.org/10.1111/odi.70247Oral Diseases 20261Metal-metronidazole derivatives as potential antitrichomonal agents on Trichomonas vaginalisRaíza Oliveira; Arquı́medes Karam; Chris H.J. Franco; M Navarro; Marlene Benchimol; Wanderley de Souza

Antiparasitic; Trichomonas vaginalis; DNA fragmentation; Cytotoxicity; Ultrastructure; Antiparasitic agent; Phosphatidylserine; In vitro; Fragmentation (computing); Biology; Microbiology; Apoptosis; Annexin; Metronidazole; Biochemistry; Protozoa; Trichomonas; Potency; Cell culture; Vacuole; Cytoplasm; Cytotoxic T cell

2026-02-13https://doi.org/10.1016/j.exppara.2026.109111Experimental Parasitology 20261Search for heavy neutral leptons in decays of W bosons produced in 13 TeV pp collisions using prompt signatures in the ATLAS detectorAbstract The existence of right-handed neutrinos with Majorana masses below the electroweak scale could help address the origins of neutrino masses, the matter–antimatter asymmetry, and dark matter. In this paper, leptonic decays of W bosons from 140 fb $$^{-1}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mmultiscripts> <mml:mrow/> <mml:mrow/> <mml:mrow> <mml:mo>-</mml:mo> <mml:mn>1</mml:mn> </mml:mrow> </mml:mmultiscripts> </mml:math> of 13 TeV proton–proton collisions at the LHC, reconstructed in the ATLAS experiment, are used to search for heavy neutral leptons produced through their mixing with muon or electron neutrinos in a scenario with lepton number violation. The search is conducted using prompt leptonic decay signatures. The considered final states require two same-charge leptons or three leptons, while vetoing three-lepton same-flavour topologies. No significant excess over the expected Standard Model backgrounds is found, leading to constraints on the heavy neutral lepton’s mixing with muon and electron neutrinos for heavy-neutral-lepton masses. The analysis excludes $$|U_{e}|^2$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:mrow> <mml:mo>|</mml:mo> </mml:mrow> <mml:msub> <mml:mi>U</mml:mi> <mml:mi>e</mml:mi> </mml:msub> <mml:msup> <mml:mrow> <mml:mo>|</mml:mo> </mml:mrow> <mml:mn>2</mml:mn> </mml:msup> </mml:mrow> </mml:math> values above $$8\times 10^{-5}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:mn>8</mml:mn> <mml:mo>×</mml:mo> <mml:msup> <mml:mn>10</mml:mn> <mml:mrow> <mml:mo>-</mml:mo> <mml:mn>5</mml:mn> </mml:mrow> </mml:msup> </mml:mrow> </mml:math> and $$|U_{\mu }|^2$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:mrow> <mml:mo>|</mml:mo> </mml:mrow> <mml:msub> <mml:mi>U</mml:mi> <mml:mi>μ</mml:mi> </mml:msub> <mml:msup> <mml:mrow> <mml:mo>|</mml:mo> </mml:mrow> <mml:mn>2</mml:mn> </mml:msup> </mml:mrow> </mml:math> values above $$5.0 \times 10^{-5}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:mn>5.0</mml:mn> <mml:mo>×</mml:mo> <mml:msup> <mml:mn>10</mml:mn> <mml:mrow> <mml:mo>-</mml:mo> <mml:mn>5</mml:mn> </mml:mrow> </mml:msup> </mml:mrow> </mml:math> in the full mass range of 8–65 GeV. The strongest constraints are placed on heavy-neutral-lepton masses in the range 15–30 GeV of $$|U_{e}|^2 < 1.1 \times 10^{-5}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:mrow> <mml:mo>|</mml:mo> </mml:mrow> <mml:msub> <mml:mi>U</mml:mi> <mml:mi>e</mml:mi> </mml:msub> <mml:msup> <mml:mrow> <mml:mo>|</mml:mo> </mml:mrow> <mml:mn>2</mml:mn> </mml:msup> <mml:mo><</mml:mo> <mml:mn>1.1</mml:mn> <mml:mo>×</mml:mo> <mml:msup> <mml:mn>10</mml:mn> <mml:mrow> <mml:mo>-</mml:mo> <mml:mn>5</mml:mn> </mml:mrow> </mml:msup> </mml:mrow> </mml:math> and $$|U_{\mu }|^2 < 5 \times 10^{-6}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:mrow> <mml:mo>|</mml:mo> </mml:mrow> <mml:msub> <mml:mi>U</mml:mi> <mml:mi>μ</mml:mi> </mml:msub> <mml:msup> <mml:mrow> <mml:mo>|</mml:mo> </mml:mrow> <mml:mn>2</mml:mn> </mml:msup> <mml:mo><</mml:mo> <mml:mn>5</mml:mn> <mml:mo>×</mml:mo> <mml:msup> <mml:mn>10</mml:mn> <mml:mrow> <mml:mo>-</mml:mo> <mml:mn>6</mml:mn> </mml:mrow> </mml:msup> </mml:mrow> </mml:math> .G. Aad; E. Aakvaag; B. Abbott; Sara Abdelhameed; Karin Abeling; N. J. Abicht; S. H. Abidi; Mohammed Aboelela; A. Aboulhorma; H. Abramowicz; Y. Abulaiti; B. S. Acharya; Alexander Ackermann; C. Adam Bourdarios; L. Adamczyk; S. V. Addepalli; M. J. Addison; J. Adelman; A. Adiguzel; Tim Adye; A. A. Affolder; Y. Afik; M. N. Agaras; A. Aggarwal; C. Agheorghiesei; F. Ahmadov; S. Ahuja; X. Ai; G. Aielli; A. Aikot; M. Ait Tamlihat; B. Aitbenchikh; M. Akbiyik; T. P. A. Åkesson; A. V. Akimov; D. Akiyama; N. N. Akolkar; S. Aktas; G. L. Alberghi; Jeffrey Ryan Albert; Una Helena Alberti; P. Albicocco; G. L. Albouy; S. Alderweireldt; Z. L. Alegria; Martin Aleksa; I. N. Aleksandrov; Călin Alexa; T. Alexopoulos; F. Alfonsi; M. Algren; M. Alhroob; B. Ali; H. M. J. Ali; S. Ali; S. W. Alibocus; M. Aliev; G. Alimonti; W. Alkakhi; C. Allaire; B. M. M. Allbrooke; J. S. Allen; J. F. Allen; P. P. Allport; A. Aloisio; Fernando Martín Alonso; C. Alpigiani; Z. M. K. Alsolami; A. Alvarez Fernandez; M. Alves Cardoso; M. G. Alviggi; M. Aly; Y. Amaral Coutinho; A. Ambler; C. Amelung; M. Amerl; C. G. Ames; T. Amezza; D. Amidei; B. Amini; K. Amirie; Artem Amirkhanov; S. P. Amor Dos Santos; K. R. Amos; Dimitra Amperiadou; S. An; C. Anastopoulos; T. Andeen; J. K. Anders; A. C. Anderson; A. Andreazza; S. Angelidakis; A. Angerami; A. V. Anisenkov; A. Annovi; C. Antel; E. Antipov; M. Antonelli; F. Anulli; Mayumi Aoki

Lepton; Neutrino; Muon; Electroweak interaction; Boson; MAJORANA; Lepton number; Electroweak scale; Atlas (anatomy); Physics; Particle physics; Nuclear physics; Standard Model (mathematical formulation); ATLAS experiment; Atlas detector; Elementary particle; Electron; Dark matter; Physics beyond the Standard Model; Particle decay; Large Hadron Collider; Sterile neutrino

2026-02-14https://doi.org/10.1140/epjc/s10052-025-15191-wThe European Physical Journal C 20261Co‐Simulation Microgrid With Distributed Control Based on a Multi‐Agent System and Communication With Adaptive Update RateABSTRACT This study presents a distributed control system for a multiagent co‐simulation environment, designed to regulate a direct current (DC) bus voltage in a grid‐connected microgrid (MG). The system adopts a client/server architecture, enabling seamless communication in a network of interconnected components integrated into a MG while implementing adaptive update‐rate communication to optimise data exchange efficiency. A multiagent system (MAS) orchestrates interactions between power converters, ensuring seamless operation of a DC microgrid powered by photovoltaic (PV) arrays, a battery storage system and an inverter/rectifier converter connected to the main grid. The framework integrates Python, TCP/IP sockets and industry‐standard simulators (PLECS, PSIM and RTDS) to create a co‐simulation environment. Key results demonstrate effective DC bus voltage regulation and battery voltage control (used as a proxy for SoC), ensuring system stability under varying operating conditions. The proposed approach enhances system responsiveness through adaptive update rate communication, which dynamically adjusts data transmission among agents and the MAS based on real‐time network conditions. This improvement is evidenced by a reduction of approximately in the average settling time of the secondary control layer, from to , when the communication medium delay varies during system operation under the adaptive update rate, compared with the fixed update rate scenario. These results highlight the superior dynamic performance of the hierarchical control strategy at the supervisory level.Daniel Leocádio Fernandes; Guilherme Márcio Soares; Janaina Gonçalves de Oliveira

Microgrid; Photovoltaic system; Battery (electricity); Decentralised system; Voltage; Communications system; Telecommunications network; Transmission (telecommunications); Wireless; Computer science; Control engineering; Electric power system; Settling time; Key (lock); Adaptive control; Control (management); Control system; Engineering

2026-01-01https://doi.org/10.1049/stg2.70054IET Smart Grid 20261Wind Power Forecasting for Independent System Operators: Modeling Approaches, Practical Applications, and Operational Challenges in the Brazilian ContextThe increasing share of renewable sources in power systems has heightened operational complexity due to their inherent variability and intermittency. These characteristics challenge supply–demand forecasting, which must achieve high accuracy given the dependence on meteorological conditions and the non-dispatchable nature of renewable generation. In Brazil, where the energy matrix is strongly linked to natural resource availability, reliable forecasts are essential to ensure supply security and optimize system dispatch. Improved forecasting reduces reserve requirements and thermal plant activation, yielding both economic and environmental benefits. This study proposes an original methodological framework for short-term wind power forecasting at an hourly temporal resolution, with horizons of up to one month ahead, with emphasis on operational application by Independent System Operators (ISOs), particularly in Brazil. The framework considers the regulatory environment, international best practices, and sector-specific challenges. It employs a deterministic approach that integrates global numerical weather prediction models with historical wind farm data, enabling accurate representation of wind generation variability. The methodology is scalable and can be adopted by the Brazilian Independent System Operator (ISO) as well as other ISOs worldwide. The results demonstrate robust forecasting performance, achieving an average systematic error of approximately 4.5% for hourly forecasts one day ahead. For weekly aggregations, errors remain close to 3.4% in the first forecast week and gradually increase to 6.3% by the fifth week. These outcomes highlight the effectiveness of the proposed framework in supporting short-term operational planning and enhancing system reliability, efficiency, and sustainability in contexts with high penetration of wind power.Paulo Sergio C. Nascimento; Lucas Meirelles Pires Deotti; André Luís M. Marcato; William Cossich M. Farias

Wind power; Renewable energy; Context (archaeology); Electric power system; Wind power forecasting; Scalability; Wind speed; Operational planning; Sustainability; Representation (politics); Computer science; Electricity generation; Numerical weather prediction; Variable renewable energy; Economic dispatch; Operations research

2026-01-01https://doi.org/10.1109/access.2026.3665895IEEE Access 20261Twenty Years in the Octagon: An Analysis of the Strategic Evolution and Distributional Concentration of Knockouts and Submissions in Mixed Martial ArtsThis study examined differences in finishing techniques and positional contexts across three temporal windows in the Ultimate Fighting Championship (2003–2004, 2013–2014, and 2023–2024), revealing differences consistent with a shift from greater diversity to a specialized and systematized model. Analysis of 906 finalized bouts demonstrated a marked concentration of submission finishes, with rear naked choke increasing from 15.8% to 46.8% (p ≤ 0.001), while back control was the dominant positional context (45.5%, p ≤ 0.001). In striking-based finishes, punches maintained prevalence, evolving from 77.4% (2003–2004) to 86.1% (2023–2024, p ≤ 0.001), whereas kicks declined from 20.5% to 11.3% (p ≤ 0.001). Submissions increased from 37.0% to 52.0% of all finalized bouts (p ≤ 0.001). These findings indicate a growing emphasis on specific finishing techniques, with modern mixed martial arts demonstrating increased distributional concentration in the methods used to finalize bouts. The increased frequency of certain techniques (e.g., rear naked choke and punches) among finalized fights may reflect strategic preferences, training priorities, or rule-driven changes in technique effectiveness, but cannot be interpreted as evidence of inherent technical superiority without additional data on success rates or efficiency metrics. Our data suggest that contemporary fighters have developed more direct and systematized approaches to finishing fights, reflecting the evolution of training methodologies and competitive strategies.João Paulo Nogueira da Rocha Santos; N. Almeida; Lindsei Brabec Mota Barreto; Mateus Henrique Santos; Kariny Realino Ferreira; Jonathas de Oliveira Baltar; Thais Carvalho Oliveira; Alfonso López Díaz de Durana; Diego Valenzuela Pérez; Esteban Aedo-Muñoz; Bianca Miarka; Ciro José Brito

Martial arts; Context (archaeology); Championship; Diversity (politics); Strategic planning; Political science; Geography; Engineering

2026-02-19https://doi.org/10.3390/app16042034Applied Sciences 20261Self-supervised learning for advanced load profile segmentation in distribution networksLuis H. T. Bandória; Walquiria Silva; B. F. Dias; M. E. M. Almeida

Cluster analysis; Flexibility (engineering); Segmentation; Load profile; Representation (politics); Artificial neural network; Unsupervised learning; Big data; Principal component analysis; Situation awareness; Computer science; Artificial intelligence; Data mining; Machine learning; Scalability; Energy consumption; Adaptive learning; Component (thermodynamics); Smart meter; Smart grid; Pattern recognition (psychology); Energy management; Market segmentation

2026-02-20https://doi.org/10.1016/j.segan.2026.102166Sustainable Energy Grids and Networks 20261Reusable SERS Substrate Based on AuNP/PS‐b‐P2VP Nanocomposites With Photocatalytic ActivityABSTRACT In this study, thin films of presynthesized gold nanoparticles assembled in reconstructed poly (styrene‐block‐2‐vinylpyridine) (PS‐ b ‐P2VP) thin films were utilized for sensing and UV‐induced degradation of analytes. The reusability of the substrates was assessed using Nile Blue and Rhodamine 6G as molecular probes at a concentration of 1.0 × 10 −4 mol L −1 . Surface‐enhanced Raman spectroscopy (SERS) mapping of the bands at 594 and 615 cm −1 for Nile Blue and Rhodamine 6G, respectively, demonstrated a uniform SERS signal distribution across the analyzed area, showing homogeneous dye adsorption. The nanocomposite substrates demonstrated excellent reusability, maintaining their SERS activity and degradation efficiency over four consecutive cycles. Theoretical and experimental evidence suggests that dye degradation is primarily driven by hot holes generated via interband transitions in AuNPs under UV excitation. This work demonstrates an effective dual‐function platform capable of both sensing and hot‐hole‐mediated photocatalysis, highlighting its potential for sustainable and reusable SERS applications.Moyra Freitas Vieira; Bismark Nogueira da Silva; D. Dumont dos Santos; Celly M. S. Izumi

Rhodamine 6G; Raman spectroscopy; Nanocomposite; Nile blue; Degradation (telecommunications); Substrate (aquarium); Reusability; Rhodamine B; Rhodamine; Materials science; Raman scattering; Nanotechnology; Chemical engineering; Photocatalysis; Nanoparticle; Thin film; Homogeneous; Visible spectrum; Colloidal gold; Optoelectronics; Spectroscopy; Nile red; Photochemistry

2026-02-22https://doi.org/10.1002/jrs.70123Journal of Raman Spectroscopy 20261Impact evaluation of the social electricity tariff program in Brazil: Evidence from a regression discontinuity designThis paper evaluates Brazil's Social Electricity Tariff Program and its ability to improve electricity affordability for low-income households using a sharp Regression Discontinuity Design (RDD). Using data from the 2017–2018 Family Budget Survey (IBGE, 2018), we compare households just below and just above the income eligibility cutoff to estimate the causal effect of eligibility on electricity consumption and expenditures. We find that eligible households consume on average 20 kWh less electricity per month than households just above the cutoff, consistent with under-consumption near the threshold. Eligibility also reduces monthly electricity spending by R$15.35 on average. While statistically significant, this level of relief appears too small to meaningfully ease budget constraints, potentially encouraging households to restrict electricity use to remain within more subsidized consumption brackets. The results suggest that the current benefit schedule may be insufficient to ensure adequate access to modern energy services—such as thermal comfort and information and entertainment—while maintaining payment affordability. We discuss policy adjustments to better align subsidy levels and target heterogeneous household needs, and highlight the importance of accounting for regional and seasonal variation in electricity demand.Beatriz Morgado Marcoje; Laura Carvalho Schiavon; Michelle Hallack; Danielle Carusi Machado; Mariana Weiss de Abreu

Regression discontinuity design; Impact evaluation; Tariff; Electricity; Social impact; Evaluation methods; Economic impact analysis; Economics; Economic evaluation; Program evaluation; Regression analysis; Impact assessment; Discontinuity (linguistics); Public economics; Econometrics; Difference in differences

2026-02-24https://doi.org/10.1016/j.enpol.2026.115143Energy Policy 20261Investigation of vibrational and optoelectronic properties of a RuICl Janus monolayer: A density functional theory studyJanus two-dimensional (2D) materials have attracted increasing attention due to their intrinsic out-of-plane asymmetry, which leads to unconventional electronic, optical, and vibrational properties. Here, we present a comprehensive first-principles investigation of the structural, electronic, optical, vibrational, and thermodynamic properties of the Janus RuICl monolayer using density functional theory within the GGA–PBE approximation. The optimized structure is found to be energetically and dynamically stable, as confirmed by cohesive energy calculations and phonon dispersion relations without imaginary frequencies. The electronic band structure reveals an indirect band gap of approximately 1.62 eV, originating mainly from the hybridization between Ru-d and halogen-p orbitals. Optical calculations show strong anisotropy and intense absorption in the ultraviolet region. Infrared and Raman spectra exhibit characteristic IR-active modes in the far-infrared region and dominant Raman-active A modes around 170 cm -1 , providing clear spectroscopic fingerprints of the Janus phase. Thermodynamic analysis indicates good thermal stability over a wide temperature range, with the heat capacity approaching the classical Dulong–Petit limit at high temperatures. These results establish the Janus RuICl monolayer as a promising candidate for future optoelectronic and spectroscopic applications.Paulo Jose Pinto Souza; Leonardo S. Barbosa; Willian Oliveira Santos; Edvan Moreira; David Lima Azevedo; Fernando Marques de Oliveira Moucherek

Janus; Density functional theory; Raman spectroscopy; Monolayer; Phonon; Band gap; Infrared; Ultraviolet; Density of states; Dispersion (optics); Materials science; Optoelectronics; Condensed matter physics; Anisotropy; Absorption (acoustics); Molecular physics; Electronic band structure; Thermal stability; Heat capacity; Direct and indirect band gaps; Electronic structure; Absorption spectroscopy; Chemical physics

2026-02-26https://doi.org/10.1016/j.cocom.2026.e01257Computational Condensed Matter 20261Probiotic cell-free supernatants as a strategy against antimicrobial resistance: a systematic reviewAntimicrobial resistance (AMR) is a critical global health threat that may cause up to 10 million deaths annually by 2050, requiring integrated actions within the One Health framework. The misuse of antimicrobials across human, animal, and environmental sectors has intensified the spread of multidrug-resistant bacteria, including Escherichia coli, Staphylococcus aureus , and Klebsiella pneumoniae . In this context, Lactobacillus -derived postbiotics have emerged as eco-friendly alternatives with antimicrobial and antibiofilm properties. A systematic review was conducted to consolidate scientific evidence on the strategic potential of Lactobacillus cell-free supernatants, with a specific focus on Limosilactobacillus fermentum . Studies published between 2000 and July 2025 were screened, prioritizing investigations that evaluated antimicrobial activity, biofilm inhibition, and efficacy in biological and technological models against multidrug-resistant pathogens. After screening, 95 studies were included in the analysis. L. fermentum was deliberately selected as the focus species based on consistent evidence of postbiotic efficacy against pathogenic bacteria and biofilm formation. The reviewed studies also demonstrated favorable physicochemical stability of L. fermentum cell-free derivatives, supporting their safety and scalability for applied use. This review highlights L. fermentum as a strategic model within One Health aligned approaches to combat AMR. The findings reinforce the role of postbiotics as sustainable, effective, and scalable tools for mitigating antimicrobial resistance across human, animal, and environmental interfaces.Maisah Meyhr D’Carmo Sodré; Ian David Araújo Cruz; Uener Ribeiro dos Santos; Sheila Cristina Potente Dutra Luquetti; Vania Lucia da Silva; ALESSANDRA BARBOSA FERREIRA MACHADO; Cláudio Galuppo Diniz; Cláudio Teodoro de Souza; Carla Cristina Romano; Lauro Juliano Marin; Luana Carvalho

Antimicrobial; Antibiotic resistance; Probiotic; Systematic review; Human health; Biofilm; Global health; One Health; Microbiology; Biology; Biotechnology; Medicine

2026-03-02https://doi.org/10.3389/fcimb.2026.1731341Frontiers in Cellular and Infection Microbiology 20261Platelet activation and platelet-monocyte interaction amplify thromboinflammation in obesity through adhesion molecules and endothelial IL-1R signalingPaula R.B. Dib; Mayara K.C. Fernandes; Letícia A.F. Venerando; Maria Clara B Mancini; Luiza L.R. Januzzi; MARIA TÂNIA CORREIA LIMA; Viviane P. de Souza; Camila F. Rezende; Edson C.C. Vieira; Mário Flávio C. de Lima; Eliana C.B. Toscano; Nathércia Percegoni; Jacy Gameiro; Patrı́cia T. Bozza; Eugênio D. Hottz

Endothelial activation; Platelet activation; Cell adhesion molecule; Platelet adhesiveness; Platelet; Adhesion; Intercellular Adhesion Molecule-1; Endothelium; Chemistry; Cell biology; Platelet adhesion; Signal transduction; Soluble cell adhesion molecules; Cell adhesion; Enzyme activator; Cell signaling

2026-03-04https://doi.org/10.1016/j.jtha.2026.02.002Journal of Thrombosis and Haemostasis 20261On the mechanism of ketene three-component reactionKetene three-component reaction (K-3CR) and silylative ketene three-component reaction (SK-3CR) are valuable multicomponent transformations for the efficient synthesis of α-acyloxy- and α-silyloxyacrylamides, structural motifs frequently found in bioactive compounds and strategically important synthetic intermediates. In this study, a combined investigation employing density functional theory (DFT) calculations and mass spectrometry monitoring experiments provides a detailed and consistent description of the full reaction pathways involved in both transformations. The results elucidate the principal elementary steps, intermediates, and divergence points between the K-3CR and SK-3CR, offering a unified mechanistic framework that aligns and rationalizes experimental observations reported in the literature.Marcelo H.R. Carvalho; Mateus S. Roza; BRENNO A.D. NETO; Paulo E.N. De Souza; Hélio Ferreira Dos Santos; Pedro P. de Castro; Giovanni W. Amarante

Ketene; Mechanism (biology); Reaction mechanism; Reaction intermediate; Chemistry; Photochemistry; Computational chemistry

2026-03-11https://doi.org/10.1016/j.tetlet.2026.156041Tetrahedron Letters 20261Non-immersive virtual reality telerehabilitation for motor accuracy and precision in individuals with Cerebral Palsy: A non-randomized clinical trialThis study aimed to describe motor performance, accuracy and precision, in individuals with Cerebral Palsy (CP) compared to typically developing individuals (controls), and to examine longitudinal changes during a non-immersive virtual reality (VR) telerehabilitation protocol. METHODS: The final sample included, 38 with CP and 21 controls. Controls completed a single practice session, while 29 participants with CP completed the 10-day home-based protocol, and 20 returned for a follow-up session to assess retention. Analyses followed the intention-to-treat principle, including all 38 CP participants. The intervention used the MoveHero game, performed two to three times per week, with sessions lasting at least 9 minutes under remote therapist supervision. Motor performance was assessed in a coincident timing task using absolute error (AE, accuracy), variable error (VE, precision), and percentage of hits. The study was registered in the Brazilian Clinical Trials Registry (ReBec: RBR-4kf52bv). RESULTS: The CP group had higher mean AE and VE values than controls but showed progressive improvements across practice days. Mean accuracy improved across most target positions (p < 0.05), with mean AE decreasing from 1350 ms on Day 1-895 ms on the best practice day. Controls had a mean AE of 584 ms, and participants with CP achieved similar performance in two of the four target positions. Mean VE improved notably for Target 3 (1124 ms on Day 1-811 ms on Day 9, p = 0.007), and the mean percentage of correct responses increased from 45.8% to 58.5% (p = 0.019), while controls reached 69.1%. No significant differences were found among GMFCS subgroups. Gains were maintained at follow-up (p > 0.05). CONCLUSION: Home-based non-immersive VR telerehabilitation using MoveHero effectively enhanced upper-limb motor performance in individuals with CP, regardless of functional level. These findings support VR as an accessible, motivating, and adaptable tool for promoting motor learning and continuity of care in home-based rehabilitation.Paula Lumy da Silva; Elisa de Jesus Valenzuela; Mariana Giovanelli de Carvalho; Anne Michelli Gomes Gonçalves Fontes; Julie H. Weingartner; Talita Dias da Silva-Magalhães; Íbis Ariana Peña de Moraes; Helen Dawes; Eduardo Dati Dias; Carlos Bandeira de Mello Monteiro

Telerehabilitation; Cerebral palsy; Clinical trial; Virtual reality; Clinical Practice; Randomized controlled trial; Longitudinal study; Young adult; Physical therapy; Medicine; Physical medicine and rehabilitation; Audiology; Sample size determination; Telemedicine; Analysis of variance

2026-03-13https://doi.org/10.1371/journal.pone.0343934PLoS ONE 20261Ampliação do uso de tecnologias para redução da malária por Plasmodium vivax na Amazônia brasileira: uma análise de impacto orçamentárioTafenoquine and primaquine are drugs used in the treatment of malaria due to Plasmodium vivax, but can cause hemolysis in patients with glucose-6-phosphate dehydrogenase (G6PD) enzyme deficiency. Thus, G6PD testing is recommended prior to drug administration. Tafenoquine and the G6PD quantitative point-of-care test are incorporated into the Brazilian Unified National Health System (SUS) for individuals over 16 years of age, but are not available for younger patients or by weight range. Testing for all patients eligible for primaquine treatment is also not offered in the SUS. The aim of the present study was to calculate the incremental budgetary impact of the incorporation of tafenoquine and testing for G6PD deficiency in individuals under 16 years of age and by weight. The expansion of testing for patients eligible for treatment with primaquine was also considered. The perspective of the analysis is that of the SUS for a five-year horizon. The reference population was that of the Brazilian Amazon. A budget impact model was developed and validated by managers and specialists in malaria and pharmaceutical services in the SUS. The incremental budget impact was BRL 12.5 million. The model predicted that incorporating tafenoquine would reduce hospitalization and recurrence costs by about 9% and 11%, respectively. The cost and waste of the test reagent strips impacted the results. The technologies analyzed can contribute to safer decision-making in the treatment of malaria in the Brazilian Amazon and planning if the technologies under analysis are incorporated.Márcia Gisele Santos da Costa; Ivan Ricardo Zimmermann; Ana Carolina Carioca da Costa; Ana Clara de Moraes; Márcia Pinto

Medicine; Molecular biology; Physics; Philosophy; Gynecology; Biology

2026-01-01https://doi.org/10.1590/0102-311xpt044925Cadernos de Saúde Pública 20261Analysis of the occurrence of mediumistic anomalous information reception: The case of Chico Xavier and Isidoro SantosINTRODUCTION: In-depth qualitative studies concerning exceptionally gifted mediums are very useful for investigating the occurrence of anomalous information reception, however, there is a dearth of studies with recorded evidence. OBJECTIVE: To investigate the occurrence of anomalous information reception in a recorded session with Chico Xavier, one of the 20th century's leading mediums. METHOD: Analysis of a 54-minute recording containing the reading of a mediumistic letter, two poems attributed to deceased Portuguese poets, and a dialogue in which Chico Xavier describes 18 deceased personalities. Following the identification of the verifiable information, an exhaustive investigation was carried out to assess the accuracy of the items of information and the likelihood of the medium having had prior access thereto. For the poems, a linguistic-literary, comparative analysis examined convergences and divergences of metre, style and themes between the alleged mediumistic texts and the original works of the authors. RESULTS: The poems analysed show features consistent with the claimed authorship, substantiating this attribution based on textual and comparative criteria. A total of 30 people were identified, with 65 verifiable items of information produced, of which 87.7% were classified as "Correct" and 30.8% as "Highly Improbable" or "Improbable" to have been accessed through conventional means. Conventional explanations are unlikely or highly unlikely for a considerable proportion of the items, particularly those related to Isabel Ramos. Her case is conspicuous, not only for its high degree of accuracy but also for having arisen spontaneously and for being someone who was unknown to the participants, characterising a drop-in case. CONCLUSION: Considering the complementary, diverse and highly assertive nature of the communications, the survival hypothesis offers the simplest and most parsimonious explanation for what occurred in this meeting.Carlos Miguel Pereira; Alexandre Caroli Rocha; Jorge Gomes; José Lucas; Júlio Silva; Alexander Moreira-Almeida

Identification (biology); Context (archaeology); Feature (linguistics); Subject (documents); History; Geography

2026-03-17https://doi.org/10.1016/j.explore.2026.103391EXPLORE 20261The effects of cocoa products in individuals with metabolic syndrome and related diseases: a systematic review and meta-analysisAbstract Cocoa supplementation has been shown to improve parameters related to metabolic syndrome, although results have been contradictory. We conducted a systematic review and meta-analysis to examine the effect of cocoa products on lipid and glycemic profiles, blood pressure levels, and anthropometric measurements in individuals with metabolic syndrome and related diseases. A search of PubMed, Web of Science, Embase, and Scopus was performed to identify randomized clinical trials (RCTs). To compare the effects of the cocoa product with placebo, mean differences with 95% confidence intervals (CIs) were pooled using a random-effects model. Subgroup analyses and meta-regression were performed to identify the source of heterogeneity, and study quality assessment was conducted using the GRADE approach. A total of 13 RCTs, including 16 arms, that investigated the effects of cocoa on parameters related to metabolic syndrome were included. The meta-analysis showed a significant effect of cocoa supplementation on triacylglycerol levels (-0.21 mmol/L, 95% CI: -0.40, -0.02; p = 0.0333), and subgroup analysis suggested that cholesterol levels were reduced with cocoa supplementation in patients with dyslipidemia and diabetes. Furthermore, the meta-regression analysis suggested a decrease in glycemic and lipid profiles, as well as anthropometric parameters, in studies with longer durations of cocoa supplementation. Our study suggests that cocoa intake has limited evidence of benefit, mainly for triglycerides, furthermore, effects and that the duration, type, and clinical status of patients were important determinants for favorable effects on biomarkers related to metabolic syndrome.Amanda Gomes Chagas; Bruno Giusti Camilotti; Gabriela Nascimento Gonçalves; Leandro Roberto de Macedo; Maísa Silva

Dyslipidemia; Metabolic syndrome; Glycemic; Lipid profile; Anthropometry; Subgroup analysis; Meta-analysis; Randomized controlled trial; Medicine; Confidence interval; Internal medicine; Food science; Physiology; Diabetes mellitus; Blood pressure; Glycemic index

2026-03-17https://doi.org/10.1007/s40200-026-01914-7Journal of Diabetes & Metabolic Disorders 20261Single-loop versus double-loop reconstruction after pancreatoduodenectomy: Does it impact on the risk of postoperative pancreatic fistula?Backgrounds/Aims: Postoperative pancreatic fistula (POPF) remains a significant complication following pancreatoduodenectomy (PD). It has been hypothesized that single loop (SL) reconstruction may increase the risk of POPF, leading to the proposal of double-loop (DL) reconstruction. In this approach, the pancreatic duct is connected to an isolated loop of bowel in a Roux-en-Y configuration. Methods: We conducted a retrospective multicenter study to compare various types of reconstruction after PD, analyzing data from 1,502 patients who underwent open, laparoscopic, or robotic PD across 28 centers worldwide. Propensity score matching (PSM) was applied to enhance comparability. Results: The overall rate of POPF was 34.89%, with a grade C POPF rate of 4.26%. The type of reconstruction (SL vs. DL) did not significantly impact the rates of POPF or grade C POPF, both before and after PSM. The rate of delayed gastric emptying (DGE) was 20.71%, and patients with DL reconstruction had a lower incidence of DGE both before and after PSM. Conclusions: Our study found no significant differences in the risk of POPF between SL and DL reconstruction. However, DL reconstruction is associated with a reduced risk of DGE, suggesting it may be a preferable option following open PD.Giovanni Domenico Tebala; Fanny Massimi; Francesca Duro; Ahmed Abdelsamad; Stefano Avenia; Gian Luca Baiocchi; Andrea Barberis; C Bouzid; Antoine Castel; G. Ceccarelli; Andrea Celotti; Nicola Cillara; Nicola Cinardi; Roberto Cirocchi; Maria Conticchio; Giuseppe Currò; A. Delvecchio; Raffaele Vincenzo De Rosa; Jacopo Desiderio; Antonio Di Cintio; Fabio Francesco Di Mola; Domenico Di Nardò; Alessia Fassari; Alessandro Gemini; Carlos Augusto Gomes; Gian Luca Grazi; Giuseppe Margani; Alessandro Mazzotta; Luca Morelli; Andrea Muratore; Fabrice Muscari; Edoardo Maria Muttillo; Alberto Patriti; Gaetano Piccolo; Luca Properzi; Alessandro Puzziello; Lucia Romano; Edoardo Rosso; Sara Saeidi; Andrea Sagnotta; Edoardo Saladino; Marcello Giuseppe Spampinato; L Sulpice; Nádia Tenreiro; Paolo Ubiali; Riccardo Memeo; DoS-RAP Collaborative

MEDLINE; Complication; Disease; Risk assessment; Risk factor; Medicine; Surgery

2026-03-18https://doi.org/10.14701/ahbps.26-007Annals of Hepato-Biliary-Pancreatic Surgery 20261Efficacy and safety of hemostatic net in facelift and rejuvenation surgeries (browlift and necklift): A systematic review and meta-analysisLuiz Fábio Silva Ribeiro; Lucas Rezende de Freitas; Ofonime Chantal Udoma‐Udofa; Maísa de Souza Borges; Tauãna Terra Cordeiro de Oliveira; Pedro Henrique Reginato; Samyd S. Bustos; Lucas Kreutz-Rodrigues; Karim Bakri; Basel A. Sharaf

Rejuvenation; Safety net; MEDLINE; Clinical trial; Medicine; Intensive care medicine; Surgery; Risk analysis (engineering)

2026-03-18https://doi.org/10.1016/j.bjps.2026.03.029Journal of Plastic Reconstructive & Aesthetic Surgery 20261Eccentric vs. Concentric Training: A Systematic Review and Meta-Analysis of Randomized Controlled Trials on Performance and Health Benefits Across Diverse PopulationsEccentric (ECC) and concentric (CON) muscle training produce distinct physiological responses, with potential implications for musculoskeletal, metabolic, and cardiovascular health. Therefore, our objective is to synthesize evidence from randomized controlled trials comparing the effects of ECC and CON training on strength, hypertrophy, metabolic function, and cardiovascular health across diverse adult populations. A systematic review and meta-analysis were conducted in accordance with PRISMA guidelines and registered in PROSPERO (ID: CRD42024627600). The review included eight randomized controlled trials, pooling data from a total of 441 participants. For strength-related outcomes, six studies (n = 322) were included; for hypertrophy, four studies (n = 210); and for cardiovascular measures, three studies (n = 154). Studies were assessed using the TESTEX scale. Standardized mean differences and random-effects models were applied (p ≤ 0.05). Results indicated that ECC training consistently produced moderate to large improvements in muscle strength (pooled ES = 0.95; I2 = 78.6%) and hypertrophy (pooled ES = 0.60; I2 = 62.3%), particularly in populations with chronic obstructive pulmonary disease (COPD) and older adults. The rate of force development (RFD) showed large effect sizes for ECC (RFD50: ES = 0.97; RFD100: ES = 0.95) but minimal change for CON (RFD50: ES = 0.04; RFD100: ES = 0.10). Both ECC and CON showed minimal effects on cardiovascular outcomes (heart rate and blood pressure: pooled ES range = −0.16 to 0.00; I2 = 41.8%) and limited tendon remodeling (ES = −0.18). In conclusion, ECC exercise demonstrates superior benefits for improving muscular strength, hypertrophy, and power across varied populations, particularly those with clinical conditions such as COPD. Its impact on cardiovascular health and tendon properties, however, appears limited. These findings support the integration of ECC modalities into targeted rehabilitation and performance programs.Carolina Oassé Paulafreitas Maia; Diego Ignácio Vanezuela Pérez; Rafael Pereira Azevedo Teixeira; Ciro José Brito; Esteban Aedo-Muñoz; Bianca Miarka

Randomized controlled trial; Health benefits; Concentric; Eccentric; Cardiovascular health; Strength training; Systematic review; Clinical trial; Medicine; Physical therapy; Physical medicine and rehabilitation; Pooling

2026-03-18https://doi.org/10.3390/sports14030119Sports 20261Carbohydrate-Rich Extract from Pereskia aculeata Leaves: In Vitro Prebiotic-Related Properties and Metabolic Effects in an Experimental Model of ObesityPereskia aculeata Mill. is a leafy cactus native to Brazil, whose leaves are traditionally used as food and are characterized by high nutritional value and significant mucilage content. This study aimed to evaluate the functional potential of the carbohydrate-rich extract obtained from leaves and to investigate its metabolic effects in obese male rats subjected to a litter-size reduction model. The extract was chemically characterized by physicochemical analysis and FTIR-MIR spectroscopy, which revealed spectral features consistent with arabinogalactan-type carbohydrates (absorption bands between 1,000 and 1,050 cm⁻¹). In vitro assays demonstrated antioxidant activity, with DPPH radical inhibition exceeding 60% and nitric oxide reduction exceeding 30%. In addition to promoting the growth of lactic acid bacteria in culture medium supplemented with the extract, it also showed antagonistic activity against selected Gram-negative pathogens. FTIR-MIR analysis during an in vitro gastrointestinal simulation indicated relative spectral stability. In vivo, obese rats were supplemented with the extract for 75 days (0.3%, w/v, in drinking water; 300 mg/kg body weight/day). Supplemented animals showed a reduction in visceral adiposity (-20%) and serum triglycerides (-31%) compared to obese controls (p < 0.05). The obesity model increased fasting blood glucose by approximately 19%, and supplementation reduced blood glucose by approximately 10%. Data were analyzed using appropriate parametric tests (p < 0.05). Liver parameters and histological analyses indicated protection against non-alcoholic fatty liver disease. Overall, these results corroborate the functional potential of carbohydrate fractions and provide a basis for future studies addressing microbiota-mediated mechanisms and metabolic effects.Martha Eunice de Bessa; Vívian Tomasco Andrade; Gabriele Moreira Guimarães; Ana Flávia Lawall Werneck Cerqueira; Carolina Carvalho Ramos Viana; Marianna Miranda Furtado; Renata de Freitas Mendes; Mírian Pereira Rodarte; Anderson S. Sant’Ana; Maria José Valenzuela Bell; Maria Christina Marques Nogueira Castañon; Maria Silvana Alves; Elisabeth Neumann; Elita Scio

Meal; Nitric oxide; In vitro; Lactic acid; Obesity; Antioxidant; Flavonoid; DPPH; Food science; Biology; Chemistry; Biochemistry; Carbohydrate; Nitrite; Traditional medicine; Functional food

2026-03-21https://doi.org/10.1007/s11130-026-01486-0Plant Foods for Human Nutrition 20261Severity of Cognitive Dysfunction Associates With Sarcopenia in Patients on Hemodialysis: Findings From the SARC-HD StudyOBJECTIVE: This study investigated the association between cognitive dysfunction and sarcopenia in patients on hemodialysis. METHODS: This is a cross-sectional analysis of the SARC-HD study. Cognitive function was assessed using the Mini-Mental State Examination, adjusted for literacy level. Patients were categorized with normal cognition, mild-to-moderate dysfunction, or severe cognitive dysfunction. Sarcopenia was diagnosed and staged according to the adapted European Working Group on Sarcopenia in Older People criteria, assessing handgrip strength or sit-to-stand test, calf circumference, and usual gait speed. For regression analyses (adjusted for clinically relevant confounders), confirmed and severe sarcopenia stages were combined into a binary outcome. RESULTS: A total of 946 patients were analyzed (48% ≥ 60 years, 61% male, and median dialysis vintage of 33 months). Mild-to-moderate and severe cognitive dysfunctions were observed in 38% and 18% of the cohort, respectively. Patients with cognitive dysfunction exhibited poorer physical function and lower calf circumference, higher prevalence of all sarcopenia traits, and higher rate of severe sarcopenia. In the adjusted logistic regression, only severe cognitive dysfunction was significantly associated with sarcopenia, showing 87% higher odds (adjusted odds ratio = 1.87, 95% confidence interval: 1.11-3.16) compared to the normal cognition group. In the fully adjusted model including malnutrition, this association did not remain significant (adjusted odds ratio= 1.55, 95% confidence interval: 0.86-2.82). CONCLUSIONS: In patients on hemodialysis, severe cognitive dysfunction was associated with sarcopenia, although this may be mediated by malnutrition. These findings underscore the need for integrated assessment strategies targeting both cognitive and physical declines in this population.Marvery Peterson Pinheiro Duarte; Otavio NOBREGA; Ana Carolina Marques Grangeiro; Danielle C. Moreira; Jéssica Guimarães Rodrigues Roure; Fábio A. Vieira; Maryanne Z. C. Silva; Dario R. Mondini; Henrique S. Disessa; Angélica Nickel Adamoli; Daiana Cristine Bündchen; Bruna R.M. Sant'Helena; Rodrigo Rosso Krug; Maristela Bohlke; Ricardo M. Lima; Marco Carlos Uchida; Antônio J. Inda-Filho; Maycon Moura Reboredo; Moisés Wesley; Heitor S. Ribeiro; Victor M. Baião; Jacqueline S. Monteiro; Priscila M. Varela; Fabiana L. Costa; Clara C. Rosa; Henrique L. Monteiro; Luiz R. Medina; Paulo R. Moreira; Catiussa Colling; Aparecido Pimentel Ferreira; Barbara P. Vogt

Sarcopenia; Cognition; Cognitive impairment; MEDLINE; Severity of illness; Medicine; Internal medicine; Gerontology; Physical therapy

2026-03-21https://doi.org/10.1053/j.jrn.2026.03.002Journal of Renal Nutrition 20261Safety of advanced therapies in pregnant women with inflammatory bowel disease: a systematic review and Meta-AnalysisBACKGROUND & AIMS: The expanding use of advanced IBD therapies creates an urgent need for pregnancy safety data. While anti-TNF safety is well-established, evidence for newer agents (vedolizumab, ustekinumab, and JAK inhibitors) remains limited. We aimed to quantify adverse pregnancy outcomes among women exposed to advanced therapies. METHODS: Random-effects models were used to calculate pooled prevalence estimates, with subgroup analyzes by therapeutic class. Restricted cubic spline meta-regression evaluated maternal age, disease activity, disease duration, phenotype, and third-trimester exposure as moderators. RESULTS: 67 observational studies with 17 441 pregnancies were included. Overall pooled prevalence rates were 8.2% (95% CI, 6.2-10.8) for early pregnancy loss, 8.9% (95% CI, 7.9-10.0) for preterm birth, 0.3% (95% CI, 0.2-0.6) for stillbirth, 6.6% (95% CI, 5.5-7.8) for low birth weight, 2.9% (95% CI, 2.2-3.9) for congenital malformations. JAK inhibitors and ustekinumab exposures were associated with higher pooled prevalence estimates of early pregnancy loss, while vedolizumab exposure was associated with higher estimates of preterm birth. Meta-regression identified disease duration, third-trimester exposure, maternal age, active disease, and Crohn's disease proportion as significant moderators of selected outcomes. CONCLUSION: Advanced IBD therapies demonstrate an overall favorable safety profile. Active disease, older maternal age, and longer disease duration were significant predictors of complications. Associations with third-trimester exposure do not support routine discontinuation, as this likely reflects underlying disease severity rather than treatment effect, reinforcing the priority of maintaining remission during pregnancy.Bernardo de Faria Moraes; Gustavo André Pedral Diniz Leite; Luisa Medeiros Visentini; Gabriel André Pedral Diniz Leite; Igor Boechat Silveira; Valbert Oliveira Costa Filho; Luis Pedro Possapp Beis; Leonardo Corrêa Süffert; Pedro Robson Costa Passos; Guilherme Grossi Lopes Cançado

Ustekinumab; Pregnancy; Inflammatory bowel disease; Vedolizumab; Observational study; Adverse effect; Disease; Gestation; Medicine; Obstetrics; Pediatrics; Internal medicine; Intensive care medicine; Young adult; Live birth

2026-03-01https://doi.org/10.1093/ecco-jcc/jjag035Journal of Crohn s and Colitis 20261Global, regional, and national levels and trends in maternal mortality, progress towards the Sustainable Development Goals, and mortality from COVID-19 infection in pregnant women, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023Jennifer Faith; Ira Martopullo; Michael B. Arndt; Ian D Letourneau; Hasan Aalruz; Ukachukwu O Abaraogu; Hedayat Abbastabar; Nadin M.I. Abdel Razeq; Jeza Muhamad Abdul Aziz; Deldar Morad Abdulah; Auwal Abdullahi; Abdullahi Salahudeen Abdulraheem; Mesfin Abebe; Abiy Abebe; Armita Abedi; Mehrandokht Abedini; Alemwork Abie; Olumide Abiodun; Richard Gyan Aboagye; Hassan Abolhassani; Abdullahi Tunde Aborode; Moaz Elsayed Abouelmagd; Nagah M. Abourashed; Dariush Abtahi; Rana Kamal Abu Farha; Fuad H. Abuadas; Sawsan Abuhammad; Ahmad Y. Abuhelwa; Hana J Abukhadijah; Salahdein Aburuz; Dina Abushanab; Apurba Acharya; Meshack Achore; Juan Manuel Acuna; Lisa C. Adams; Isaac Yeboah Addo; Tajudeen Adewumi Adebisi; Babatope O. Adebiyi; David Adedia; Kamoru A. Adedokun; Oyelola A. Adegboye; Olumide Thomas Adeleke; Makinde Adebayo Adeniyi; Juliana Bunmi Adetunji; Mache Tsadik Adhana; Usha Adiga; Mohd Adnan; Qorinah Estiningtyas Sakilah Adnani; Prince Owusu Adoma; Obed Adonteng-Kissi; Rotimi Felix Afolabi; Ebenezer Afrifa-Yamoah; Muhammad Sohail Afzal; Saira Afzal; Gizachew Beykaso Agafari; Thilini Chanchala Agampodi; Percival Delali Agordoh; César Agostinis Sobrinho; Shreyash Agrawal; Prince Agwu; Williams Agyemang-Duah; Bright Opoku Ahinkorah; Danish Ahmad; Adamu Adamu Ahmad; Sajjad Ahmad; M. Ahmed; Anisuddin Ahmed; Gasha Salih Ahmed; Mehrunnisha Sharif Ahmed; Nesredin Ahmed; Luai A. Ahmed; Mushood Ahmed; Ayman H. Ahmed; Kobi V. Ajayi; Oluwasefunmi Akeju; Muhammad Furqan Akhtar; Karolina Akinosoglou; Mohammed Ahmed Akkaif; Salah Al Awaidy; Syed Mahfuz Al Hasan; Nazmul Alam; Khurshid Alam; Rasmieh Mustafa Al-amer; Abebaw Alamrew; Fahmi Y. Al-Ashwal; Mohammed ALBashtawy; Jacqueline Elizabeth Alcalde-Rabanal; Nader Al-Dewik; Shereen M. Aleidi; Bezawit Abeje Alemayehu; Fentahun Alemnew; Bekalu Kassie Alemu; Fahad D. Algahtani; Robert Kaba Alhassan; Mohammed Usman Ali; Waad Ali; Irfan Ali; Rafat Ali; Mohammad Daud Ali; Kamran Ali

Sustainable development; Maternal health; Pregnancy; Burden of disease; Population; Global health; Public health; MEDLINE; Environmental health; Medicine; Economic growth

2026-03-27https://doi.org/10.1016/s3050-5038(26)00047-6The Lancet Obstetrics Gynaecology & Women s Health 20261Development and Validation of an Instrument to Assess Endodontists' Knowledge, Attitudes, and Practices Regarding Cone‐Beam Computed TomographyThere is a scarcity of data regarding knowledge, attitudes and practices (KAP) of endodontists about cone-beam computed tomography (CBCT), which may be related to the lack of valid and reliable measures. The present study aimed to develop and validate a KAP measure about CBCT. The developed measure showed good content validity and was administered to 506 endodontists. Exploratory and confirmatory factor analysis revealed a factorial structure composed of three factors (KAP) with 13 items. The measure showed evidence of good internal consistency and discriminant validity, being able to accurately discriminate KAP according to the length of experience and level of education. Taken together, results provided evidence of good psychometric properties of a new KAP measure regarding CBCT, allowing future research in the field.Lisa Morais Fernandes Oliveira; Francielle Silvestre Verner; Pedro Henrique Berbert de Carvalho; Rafael Binato Junqueira

Measure (data warehouse); Internal consistency; Computed tomography; Discriminant validity; Exploratory factor analysis; Confirmatory factor analysis; Medical physics; Reliability (semiconductor); Psychology; Medicine; Content validity; Linear discriminant analysis; Consistency (knowledge bases); Factorial analysis

2026-03-29https://doi.org/10.1111/aej.70075Australian Endodontic Journal 20261Metric Properties of the Infodemic Signs and Symptoms Scale in Brazilian Older AdultsIntroduction. Infodemics promote disinformation, triggering serious consequences. It is therefore necessary to evaluate the phenomena associated with infodemics and their effects on mental health. Objective. Construct and analyze the internal structure validity and reliability of the Infodemic Signs and Symptoms Scale (ISSS) in older adults. The ISSS was designed to track signs and symptoms indicative of psychological distress associated with exposure to information on socially critical events. Method. This is a psychometric study of the construction and validation of a measurement instrument. To conduct the study, the ISSS was administered online (web survey) and by phone to 3,003 older adults from different regions of Brazil. Results. The instrument has good reliability (Cronbach’s alpha = .97 and McDonald’s omega = .97) and excellent replicability of the construct, as borne out by the GH index (latent = .982 and observed = .884). Evidence of the quality and efficacy of the measures showed high values for both the factor determination index (.991) and the EAP marginal reliability (.982), sensitivity rate (7.452) and expected percentage of actual differences (98%). Discussion and conclusion. The instrument analyzed in this study fills a gap, as there were no validated instruments for measuring the effects of infodemics on the mental health of older adults. The analyzed evidence indicates that the ISSS has good internal structure validity and reliability for measuring the signs and symptoms of infodemics in older adults. The instrument will assist in screening for the mental distress in older adults caused by infodemics in emergency crisis contexts.Ricardo Bezerra Cavalcante; Patrícia Rodrigues Braz; Altemir José Gonçalves Barbosa; Renata Eloah de Lucena Ferretti-Rebustini; Nádia Shigaeff; Eduarda Rezende Freitas; Luan César Ferreira Simões; Regina Consolação dos Santos

Reliability (semiconductor); Metric (unit); Scale (ratio); Distress; Construct validity; Mental health; Psychometrics; Construct (python library); Psychology; Clinical psychology; Validity; Quality of life (healthcare); Criterion validity; Quality (philosophy); Mental illness; Index (typography); Internal validity

2026-03-19https://doi.org/10.17711/sm.0185-3325.2026.05Salud Mental 20261Lessons from a socioenvironmental conflict: Why banning traditional practices threatens fire‐prone plant conservation in tropical savannasAbstract Understanding the demographic consequences of harvesting non‐timber forest products (NTFPs) is essential for developing inclusive conservation strategies that balance sustainability with local livelihoods. We assessed the population dynamics of Comanthera elegans , an endangered and endemic species from Brazil's Cerrado biome, traditionally managed through inflorescence harvesting and fire by the Apanhadores de Flores Sempre‐Vivas (AFSV). These practices, despite their traditional ecological basis, have been criminalized under national conservation policy. Between 2017 and 2019, we monitored 19,273 individuals across 120 permanent 1 × 1 m plots under six treatments combining fire and harvest timing. We applied integral projection models (IPMs) over two‐time intervals to estimate population growth rates ( λ ), elasticity and life table response experiments (LTREs), followed by 20‐year projections under each treatment. Our results demonstrate that traditional practices, especially fire use and late harvest, consistently support positive population growth ( λ up to 1.87), while control and early harvest scenarios showed demographic stagnation or decline. Elasticity and LTRE analyses revealed that the survival and growth of larger individuals are the primary drivers of λ variation. Synthesis and applications . This study illustrates how evidence‐based traditional management can enhance long‐term population viability. As conservation efforts worldwide increasingly prioritize equity, participation and effectiveness, this case provides globally relevant insights into the risks of excluding local knowledge from policy design. We advocate for adaptive governance models that incorporate traditional ecological knowledge, participatory decision‐making, and the co‐creation of fire and harvest management protocols. The findings contribute to a growing international call to integrate culturally grounded practices into biodiversity conservation, especially in fire‐prone ecosystems and socioecologically complex landscapes.Thiago da Silva Novato; Juliana Loureiro Almeida Campos; Rita de C. Q. Portela; Eduardo Mendes; Gustavo Taboada Soldati

Sustainability; Population growth; Population; Adaptive management; Endangered species; Fire regime; Adaptive strategies; Population model; Geography; Agroforestry; Environmental resource management; Ecology; Biodiversity; Environmental planning; Traditional knowledge; Population projection

2026-04-01https://doi.org/10.1111/1365-2664.70348Journal of Applied Ecology 20261Chitosan Films Incorporating Cellulose Nanofibers or Carbon Nanotubes Differentially Modulate Early Responses of Stem Cells from Human Exfoliated Deciduous TeethEarly stem cell-material interactions are critically governed by interfacial physicochemical cues. In this study, chitosan films incorporating cellulose nanofibers (CNFs) or carbon nanotubes (CNTs) were investigated as distinct nanomaterial strategies to modulate the morphology and viability of stem cells from human exfoliated deciduous teeth (SHED). The films were prepared by solvent casting followed by ionic crosslinking and characterized in terms of surface morphology, chemical structure, swelling behavior, and wettability. CNF-containing films exhibited a granular distribution of nanoscale surface features and reduced apparent wettability, whereas CNT-containing films displayed an irregular distribution of nanoscale surface features with greater topographical complexity. SHED responses were evaluated through qualitative morphological assessment, quantitative cell-spreading analysis, metabolic activity assays (Alamar Blue and MTT), and membrane integrity testing (Trypan Blue). CNF/Ch films restricted cell spreading and were associated with reduced metabolic activity and membrane integrity. In contrast, CNT/Ch films supported enhanced cell spreading, maintained high Alamar Blue-derived metabolic activity, and exhibited recovery of membrane integrity after 72 h. Collectively, these findings demonstrate that CNFs and CNTs impart distinct interfacial cues to chitosan films, leading to differential early SHED responses and identifying CNT/Ch as the most supportive formulation among those tested under the present conditions. This work underscores the importance of nanomaterial-driven surface features in guiding early stem cell-material interactions and provides insights for the design of chitosan-based substrates for regenerative medicine applications.Rosana Isabel da Costa Nascimento; Rebecca Vasconcellos; Leonara Beatriz Fayer de Almeida Campos; Eduarda Rocha de Oliveira; Caroline da Silva Almeida Ferreira; Luiz O. Ladeira; Luiz Fernando Cappa de Oliveira; Carlos Magno da Costa Maranduba; Michele Munk

Nanofiber; Cellulose; Chitosan; Carbon nanotube; Stem cell; Deciduous; Chemistry; Chemical engineering; Nanotechnology; Bacterial cellulose; Deciduous teeth; Biophysics

2026-04-02https://doi.org/10.1021/acsabm.6c00220ACS Applied Bio Materials 20261A strategy for concrete cracking simulation using high aspect ratio interface damage elements and rule-of-mixture-based equivalent propertiesCapturing the influence of concrete mesostructure at the macroscale remains a significant challenge in computational modeling. This paper presents a novel methodology for simulating concrete cracking at the macroscale while considering mesoscale characteristics and overcoming the difficulties of generating computational specimens. To this end, a tensile damage model incorporating high aspect ratio interface elements via mesh fragmentation is employed to capture nonlinear behavior. The Rule of Mixture is utilized to derive effective properties. A notched square plate under uniaxial tensile loading is simulated, and the average result from five mesoscale realizations is compared with a single macroscale result, considering varying aggregate fractions and shapes. A three-point bending test and an L-shaped panel test are also performed to verify the effectiveness of the strategy under different fracture modes, and the results are compared with experimental and computational references. The findings demonstrate the efficacy of the approach in capturing mesoscale characteristics through macroscale analysis, encouraging further application to more complex analyses, such as thermomechanical or three-dimensional problems, which involve more computationally demanding aggregate arrangements in the mortar matrix.Lahis Assis; Michèle Cristina Resende Farage; Flávia de Souza Bastos

Mesoscale meteorology; Aggregate (composite); Cracking; Ultimate tensile strength; Mortar; Bending; Nonlinear system; Fracture (geology); Materials science; Structural engineering; Composite material; Interface (matter); Cohesive zone model; Material properties; Fracture mechanics; Tensile testing; Aspect ratio (aeronautics)

2026-04-07https://doi.org/10.1177/10567895261440413International Journal of Damage Mechanics 20261Kinetics and Mechanism of the Enantioselective Passerini Multicomponent Reaction Catalyzed by Chiral Ionic LiquidsHerein, we present the development of an enantioselective methodology for the classic Passerini three-component reaction, utilizing the asymmetric counteranion-directed catalysis (ACDC) effect combined with an ionic liquid catalyst to harness the ionic liquid effect. By combining both the ACDC and ionic liquid effects, the desired Passerini products were obtained in yields of up to 93% and with enantiomeric ratios of 94:6. To the best of our knowledge, this marks the first report of an asymmetric protocol for the classic Passerini reaction utilizing ACDC effects. DLS experiments provided insights into the catalyst's effect through the formation of ionic aggregates and highlighted the importance of the solvent in achieving higher yields. NMR investigations revealed that the reaction mechanism proceeds through the formation of nitrilium and imidate species as key intermediates, followed by a Mumm rearrangement. Theoretical calculations confirmed S-isomer selectivity, with van der Waals forces stabilizing the transition state and the ionic liquid crucial to chiral catalysis. The first kinetics experiments conducted for this multicomponent reaction (MCR) provided additional support for these findings.Juliana Santos; Pedro P. de Castro; Saulo T. A. Passos; Virgínia C. Rufino; Fabricio Machado; Daniel M. Araújo; Hélio F. Dos Santos; Brenno A. D. Neto; Giovanni W. Amarante

Ionic liquid; Catalysis; Enantioselective synthesis; Kinetics; Mechanism (biology); Reaction mechanism; Chemistry; Organic chemistry; Combinatorial chemistry

2026-04-16https://doi.org/10.1021/acsomega.5c13327ACS Omega 20261TargetingFLT3 in Acute Myeloid Leukemia: StructuralInsights and Key ChallengesAbstract Mutations in FLT3 (FMS-like tyrosine kinase 3) are directly related to the development of acute myeloid leukemia (AML), contributing to the dysregulated proliferation and survival of malignant myeloid cells. FLT3 inhibitors (FLT3i), such as gilteritinib and quizartinib, have demonstrated relevant clinical benefits, including symptom relief and increased overall survival in patients with AML. However, the duration of response to FLT3i remains limited due to the emergence of resistance. In this scenario, the development of targeted therapies has emerged as a promising strategy to overcome these limitations, aiming to address the restrictions observed in the previous generation. These approaches range from the combination of FLT3i with other antileukemic agents to the use of multitarget inhibitors capable of simultaneously modulating FLT3 and other relevant molecular targets, as well as the development of next-generation inhibitors that are more selective and capable of maintaining activity against secondary mutations, such as the gatekeeper mutation (F691L), which confers resistance to clinically available drugs. This review article addresses the therapeutic relevance of FLT3i in AML and provides an overview of the binding modes of representative FLT3 inhibitors. Structural and conformational aspects involved in the interaction with this target, with emphasis on the ATP-binding site, as well as the impact of resistance-associated mutations, are discussed. In addition, this work seeks to correlate the binding modes described in the literature with experimental activity data.Michele Rodrigues da Silva; L C V Lima; Maria Letícia de Castro Barbosa

Myeloid leukemia; Tyrosine kinase; Myeloid; Leukemia; Myeloid cells; Acquired resistance; Mutation; Kinase; Medicine; Cancer research; Computational biology; Bioinformatics

2026-04-20https://doi.org/10.1021/acsbiomedchemau.6c00021ACS Bio & Med Chem Au 20261Nutritional intervention rich in tryptophan enhances sleep duration and reduces wakefulness during breast cancer treatmentBackground: Sleep disorders are highly prevalent among women undergoing treatment for breast cancer, often exacerbated by the side effects of chemotherapy. Nutritional strategies using foods rich in tryptophan and precursors of melatonin may help regulate sleep, but evidence in cancer populations remains limited.Objective: To evaluate the effect of a tryptophan-rich dietary intervention on sleep parameters in women undergoing chemotherapy for breast cancer.Methods: Fifty women were randomized into a Sleep Diet Group (SDG) that received a tryptophan-rich meal plan (>3000 mg/day) or a Control Group (CG) that received a diet without specific foods to facilitate sleep. Sleep was monitored daily for six weeks using actigraphy (Mi Band 4C®), assessing total sleep time (TST), light sleep, deep sleep and wake after sleep onset (WASO). Fatigue and insomnia severity were assessed before and after the intervention.Results: The SDG had significantly higher TST compared to the CG in weeks 4 and 5 (p = 0.007 and p = 0.010, respectively). WASO was significantly lower in the SDG during weeks 2 and 4 (p = 0.011 and p = 0.035). No significant differences in deep sleep were observed between groups (p = 0.214). Both groups showed subjective improvements in insomnia severity, with no differences between groups. Fatigue scores remained unchanged.Conclusion: A dietary intervention with tryptophan-rich foods improved total sleep time and reduced nighttime awakenings in women undergoing breast cancer treatment. These findings suggest that targeted nutritional strategies may support sleep regulation during chemotherapy.Henriqueta Vieira Van Keulen; Guilherme Eugênio Van Keulen; Jéssica Pereira Silva; Renato Moreira Nunes; A Hernández Aguiar

Actigraphy; Sleep (system call); Insomnia; Melatonin; Breast cancer; Wakefulness; Sleep onset; Meal; Slow-wave sleep; Medicine; Internal medicine; Sleep diary; Sleep disorder; Nutritional Supplementation; Randomized controlled trial; Intervention (counseling); Sleep deprivation; Sleep onset latency; Oncology

2026-04-25https://doi.org/10.1080/1028415x.2026.2650633Nutritional Neuroscience 20261Interpretative Modeling of UHPC for Strength and Eco-Efficiency AssessmentThe growing demand for sustainable construction has intensified the need for advanced materials and robust assessment frameworks that integrate mechanical performance with environmental efficiency. Ultrahigh performance concrete (UHPC) stands out for its exceptional strength and durability, but presents environmental challenges due to its high cement content. This study introduces an integrated framework to evaluate the mechanical and environmental performance of UHPC, utilizing predictive models and interpretative analyses to quantify compressive strength (fc), embodied CO2 index (CI), and embodied energy index (EI). Drawing from a database of 918 UHPC mixtures and validated with seven nonproprietary compositions, the framework leverages multiple linear regression (MLR) and artificial neural networks (ANNs). To interpret variable interactions and nonlinear behaviors, Pearson correlation and SHapley Additive exPlanations (SHAP) are employed, offering insights into mix adjustments. Findings suggest that cement dosages between 600 and 900 kg/m3 optimize the balance between strength and environmental impact. SHAP analysis underscores the nonlinear contributions of supplementary cementitious materials (SCMs), including silica fume, limestone powder, quartz powder, slag, fly ash, and nanosilica, to both strength and sustainability. Moreover, optimized fiber content and curing temperatures of 80°C–90°C are shown to enhance eco-efficiency. The proposed framework enhances predictive accuracy while supporting sustainable UHPC design through data-driven insights into environmental efficiency, aligning material selection with circular economy principles and carbon reduction goals.Vinicius Brother dos Santos; Carlos Alberto Benedetty Torres; Paula de Oliveira Ribeiro; Pablo Augusto Krahl; Flávio de Andrade Silva; Sérgio Cirelli Angulo; Alexandre Rossi; Carlos Humberto Martins

Cementitious; Embodied energy; Compressive strength; Sustainability; Nonlinear system; Cement; Curing (chemistry); Fly ash; Strength of materials; Computer science; Predictive modelling; Environmental science; Structural engineering; Civil engineering; Artificial neural network; Mechanical strength; Linear regression; Infill; Regression analysis; Durability

2026-04-27https://doi.org/10.1061/jmcee7.mteng-20939Journal of Materials in Civil Engineering 20261PLANeT: Understanding and leveraging the genome of land plants for a sustainable futureLand plants underpin civilization and planetary health, yet their genomic diversity remains largely uncharted. Current resources are unstandardized and scarce, lacking reference genomes for 95% of genera, 70% of families, and 51% of orders, impeding evolutionary and functional insight. We thus propose the PLANeT initiative, an international effort to generate high-quality, standardized genomes across the plant tree of life. Integrating artificial intelligence (AI) with genomics, we will decode conserved principles to advance fundamental plant biology, biodiversity conservation, crop improvement, and natural product discovery. Engaging around 100 labs to train 1,000 scientists, we will tackle pivotal questions for a sustainable future.Li Wang; Mohamed Amar; Carlos I. Arbizu; John L. Bowman; Charles H. Cannon; David J. Cantrill; Xiaofeng Cao; Shilin Chen; Xiaoya Chen; Xuemei Chen; Kang Chong; Xingwang Deng; E Weinan; Hongwei Guo; Chuan He; Peter Hollingsworth; Qing Hu; Hongzhi Kong; Ilia J Leitch; Dezhu Li; Li J; Hongtao Liu; William Lucas; Eshchar Mizrachi; Mijoro Rakotoarinivo; Hai Ren; Loren Rieseberg; Jue Ruan; Rosa Scherson; Harald Schneider; Douglas E Soltis; Han Sun; Marcio C. Silva-Filho; S Smith; Alex D. Twyford; Björn Usadel; Yves Van de Peer; Cássio van den Berg; Rajeev K Varshney; Lyderson Fácio Viccini; Qingfeng Wang; Xiaoquan Wang; Yue Wang; Jonathan Wendel; Rod Wing; Gane Ka‐Shu Wong; Yaowu Xing; Xun Xu; Nieng Yan; Huanming Yang; Shouzhou Zhang; Yuxian Zhu; Pamela S. Soltis; Detlef Weigel; Sanwen Huang

Biodiversity; Genome; Product (mathematics); Diversity (politics); Genomics; Tree of life (biology); Sustainable production; Tree (set theory); Biology; Geography; Environmental resource management; Environmental planning; Ecology

2026-04-01https://doi.org/10.1016/j.cell.2026.01.026Cell 20261Precise measurement of the $$t\bar{t}$$ production cross-section and lepton differential distributions in $$ e\mu $$ dilepton events from $$\sqrt{s}=13\,\text {TeV}$$ pp collisions with the ATLAS detectorAbstract The inclusive top quark pair ( $$t\bar{t}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:mi>t</mml:mi> <mml:mover> <mml:mrow> <mml:mi>t</mml:mi> </mml:mrow> <mml:mrow> <mml:mo>¯</mml:mo> </mml:mrow> </mml:mover> </mml:mrow> </mml:math> ) cross-section $$\sigma _{t\bar{t}}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msub> <mml:mi>σ</mml:mi> <mml:mrow> <mml:mi>t</mml:mi> <mml:mover> <mml:mrow> <mml:mi>t</mml:mi> </mml:mrow> <mml:mrow> <mml:mo>¯</mml:mo> </mml:mrow> </mml:mover> </mml:mrow> </mml:msub> </mml:math> has been measured in proton–proton collisions at $$\sqrt{s}=13\,\text {TeV}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:msqrt> <mml:mi>s</mml:mi> </mml:msqrt> <mml:mo>=</mml:mo> <mml:mn>13</mml:mn> <mml:mspace/> <mml:mtext>TeV</mml:mtext> </mml:mrow> </mml:math> , using $$140\,{\text {fb}^{-1}} $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:mn>140</mml:mn> <mml:mspace/> <mml:msup> <mml:mtext>fb</mml:mtext> <mml:mrow> <mml:mo>-</mml:mo> <mml:mn>1</mml:mn> </mml:mrow> </mml:msup> </mml:mrow> </mml:math> of data collected by the ATLAS experiment at the Large Hadron Collider. Using events with an opposite-charge $$e\mu $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:mi>e</mml:mi> <mml:mi>μ</mml:mi> </mml:mrow> </mml:math> pair and b -tagged jets, the cross-section is measured to be: $$\begin{aligned} \sigma _{t\bar{t}} & = 829.3\pm 1.3\,\mathrm {(stat)}\ \pm 8.0\,\mathrm {(syst)}\ \pm 7.3\,\mathrm {(lumi)}\ \\ & \quad \pm 1.9\,\mathrm {(beam)}\,\textrm{pb}, \end{aligned}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:mtable> <mml:mtr> <mml:mtd> <mml:msub> <mml:mi>σ</mml:mi> <mml:mrow> <mml:mi>t</mml:mi> <mml:mover> <mml:mrow> <mml:mi>t</mml:mi> </mml:mrow> <mml:mrow> <mml:mo>¯</mml:mo> </mml:mrow> </mml:mover> </mml:mrow> </mml:msub> </mml:mtd> <mml:mtd> <mml:mrow> <mml:mo>=</mml:mo> <mml:mn>829.3</mml:mn> <mml:mo>±</mml:mo> <mml:mn>1.3</mml:mn> <mml:mspace/> <mml:mrow> <mml:mo>(</mml:mo> <mml:mi>stat</mml:mi> <mml:mo>)</mml:mo> </mml:mrow> <mml:mspace/> <mml:mo>±</mml:mo> <mml:mn>8.0</mml:mn> <mml:mspace/> <mml:mrow> <mml:mo>(</mml:mo> <mml:mi>syst</mml:mi> <mml:mo>)</mml:mo> </mml:mrow> <mml:mspace/> <mml:mo>±</mml:mo> <mml:mn>7.3</mml:mn> <mml:mspace/> <mml:mrow> <mml:mo>(</mml:mo> <mml:mi>lumi</mml:mi> <mml:mo>)</mml:mo> </mml:mrow> <mml:mspace/> </mml:mrow> </mml:mtd> </mml:mtr> <mml:mtr> <mml:mtd> <mml:mrow/> </mml:mtd> <mml:mtd> <mml:mrow> <mml:mspace/> <mml:mo>±</mml:mo> <mml:mn>1.9</mml:mn> <mml:mspace/> <mml:mrow> <mml:mo>(</mml:mo> <mml:mi>beam</mml:mi> <mml:mo>)</mml:mo> </mml:mrow> <mml:mspace/> <mml:mtext>pb</mml:mtext> <mml:mo>,</mml:mo> </mml:mrow> </mml:mtd> </mml:mtr> </mml:mtable> </mml:mrow> </mml:math> where the uncertainties reflect the limited size of the data sample, experimental and theoretical systematic effects, the integrated luminosity, and the proton beam energy, giving a total uncertainty of 1.3%. The result is used to determine the top quark pole mass via the dependence of the predicted cross-section on $${m_{t}^\textrm{pole}}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msubsup> <mml:mi>m</mml:mi> <mml:mrow> <mml:mi>t</mml:mi> </mml:mrow> <mml:mtext>pole</mml:mtext> </mml:msubsup> </mml:math> , givingG. Aad; E. Aakvaag; B. Abbott; S. Abdelhameed; K. Abeling; N. J. Abicht; S. H. Abidi; M. Aboelela; A. Aboulhorma; H Abramowicz; Y. Abulaiti; B. S. Acharya; A. Ackermann; C. Adam Bourdarios; L. Adamczyk; S. V. Addepalli; M. J. Addison; J. Adelman; A. Adiguzel; T. Adye; A. A. Affolder; Y. Afik; M. N. Agaras; A. Aggarwal; C. Agheorghiesei; F. Ahmadov; S. Ahuja; S. Ahuja; X. Ai; G. Aielli; A. Aikot; M. Ait Tamlihat; B. Aitbenchikh; T. P. A. Åkesson; A. V. Akimov; D. Akiyama; N. N. Akolkar; S. Aktas; G. L. Alberghi; J. Albert; U. Alberti; P. Albicocco; G. L. Albouy; S. Alderweireldt; Z. L. Alegria; M. Aleksa; I. N. Aleksandrov; C. Alexa; T. Alexopoulos; F. Alfonsi; M. Algren; M. Alhroob; B. Ali; H. M. J. Ali; S. Ali; S. W. Alibocus; M. Aliev; G. Alimonti; W. Alkakhi; C. Allaire; B. M. M. Allbrooke; D. R. Allen; J. S. Allen; J. F. Allen; P. P. Allport; A ALOISIO; F. Alonso; C. Alpigiani; Z. M. K. Alsolami; A. Alvarez Fernandez; M. Alves Cardoso; M ALVIGGI; M. Aly; Y A Coutinho; A. Ambler; C. Amelung; M. Amerl; C. G. Ames; T. Amezza; D. Amidei; B. Amini; K. Amirie; A. Amirkhanov; S. P. Amor Dos Santos; K. R. Amos; D. Amperiadou; S. An; C. Anastopoulos; T. Andeen; J. K. Anders; A. C. Anderson; A. Andreazza; S. Angelidakis; A. Angerami; A. V. Anisenkov; A. Annovi; C. Antel; E. Antipov; M. Antonelli; F. Anulli

Atlas detector; Atlas (anatomy); Lepton; Hadron; Large Hadron Collider; Detector; Physics; Particle physics; Nuclear physics; Pair production; Top quark; ATLAS experiment; Production (economics); Quark

2026-05-05https://doi.org/10.1140/epjc/s10052-026-15311-0The European Physical Journal C 20261Divergent recovery of woody plant community in Cerrado-Caatinga ecotone after agricultural abandonmentRonaldo de Araújo Ibiapina; Vitor de Andrade Kamimura; Pedro Manuel Villa; Abel Augusto Conceição; Rodrigo Ferreira De [UNESP] Morais

Ecotone; Vegetation (pathology); Shrub; Plant community; Agricultural land; Land use; Agriculture; Basal area; Geography; Ecology; Agroforestry; Species diversity; Plant cover; Community structure; Woody plant; Ecological succession; Beta diversity; Land cover; Forestry; Regeneration (biology); Intraspecific competition

2026-05-05https://doi.org/10.1007/s44473-026-00161-1Plant Biosystems - An International Journal Dealing with all Aspects of Plant Biology 20261Multifunctional Alginate‐Based Films Reinforced With Ag‐ZnO/AgO/TiO 2 Nanocomposites for Advanced Packaging and Biomedical ApplicationsABSTRACT The Ag‐ZnO/AgO/TiO 2 nanocomposite (NCP) demonstrates excellent antibacterial, biocompatible, wound‐healing, and leishmanicidal properties, highlighting its multifunctionality. This study presents sodium alginate‐based films reinforced with 0.5% and 1% (w/w) of the ternary NCP to integrate photocatalytic, antimicrobial, and UV‐shielding effects. Rheological analysis showed that 0.5% NCP increased the elastic modulus by 32% and reduced the damping factor, indicating improved polymer structuring and viscoelastic stability. Thermogravimetric results revealed a 21% rise in decomposition onset temperature, confirming enhanced thermal resistance. Optical analysis indicated that 0.5% NCP maintained 92% transparency at 600 nm while improving UV‐blocking capacity, especially at 1% loading. Raman and SEM/EDS confirmed uniform nanoparticle dispersion within the matrix. Mechanical tests showed a 25% increase in tensile strength and 30% higher stiffness, with an 18% lower swelling ratio, evidencing effective reinforcement. Antibacterial assays against Staphylococcus aureus and Escherichia coli exhibited inhibition zones of 10–12 mm, with stronger effects at 1% NCP, due to the which can be attributed to the combined action of Ag, ZnO, and TiO 2 components embedded within the alginate matrix. The incorporation of this multifunctional nanocomposite into alginate films represents a notable advancement, producing transparent, thermally stable, and antimicrobial biopolymers for sustainable packaging and biomedical uses.Adriana dos Santos Silva; Davi Porfírio Silva; Alysson Nogueira Magalhães; Marcos Vinicius Dias Vermelho; Ângelo Márcio Leite Denadai; Anielle Christine Almeida Silva

Nanocomposite; Thermogravimetric analysis; Ternary operation; Ultimate tensile strength; Polymer; Rheology; Swelling; Dispersion (optics); Polymer nanocomposite; Materials science; Composite material; Viscoelasticity; Nanoparticle; Thermal decomposition; Dynamic mechanical analysis; Polyamide; Electrospinning; Sodium alginate; Thermal stability; Modulus; Young's modulus; Thermal analysis

2026-05-01https://doi.org/10.1002/admi.202500575Advanced Materials Interfaces 20261EFFECTS OF ISCHEMIC PRECONDITIONING ON RESISTANCE EXERCISE PERFORMANCE: A SYSTEMATIC REVIEWObjective: this systematic review aimed to synthesize the evidence on the effects of ischemic preconditioning (IPC) on resistance exercise performance, as well as to identify methodological patterns across studies and discuss its practical applicability. Methodology: the review was conducted in accordance with PRISMA recommendations and registered in PROSPERO (CRD42024529191). Searches were carried out in January 2026 in PubMed, Scopus, SPORTDiscus, and Web of Science. Randomized experimental studies involving healthy adults, trained or untrained, submitted to IPC and compared with control or sham conditions, with assessment of strength, muscular endurance, and muscle thickness, were included. Of the 1,340 records initially identified, 11 studies met the eligibility criteria and composed the final synthesis. Results: overall, the studies showed satisfactory methodological quality, although risk-of-bias assessment indicated a predominance of 'some concerns,' particularly regarding randomization and the selection of reported results. Findings showed that IPC was mainly associated with acute ergogenic effects, including increases in repetitions to failure, total training volume, and, in some cases, maximal strength. The few chronic studies also suggested benefits for strength gains, but without consistent evidence of increased muscle thickness. Conclusions: it is concluded that IPC has the potential to improve resistance exercise performance, although methodological heterogeneity and the possible influence of placebo-related factors require cautious interpretation.Pedro Augusto Mariz Dantas; Camille Dos Reis Molina; Jefferson da Silva Novaes; Adenilson Targino de Araújo Júnior; Pedro Henrique Marques de Lucena; Carlos Renato Paz; Natália Herculano Paz; Igor Mariz Dantas; Clizaldo Luiz Maroja Di Pace França; Camila Fernandes Pontes Dos Santos; João Gabriel de Vasconcelos Chaves Pinheiro; Fábio Thiago Maciel da Silva; Daniel Almeida Marinho; Maria do Socorro Cirilo-Sousa

Ischemic preconditioning; Resistance training; Systematic review; Randomized controlled trial; Muscle strength; Randomization; Medicine; Physical therapy; Physical medicine and rehabilitation; Internal medicine; Selection (genetic algorithm); Cardiology; MEDLINE

2026-05-08https://doi.org/10.66104/af0s1t29Revista Multidisciplinar do Nordeste Mineiro 20261Jabuticaba ( Plinia cauliflora ) as a Source of Bioactive Phenolics: Extraction and Microencapsulation by Spray DryingJabuticaba (Plinia cauliflora), a Brazilian berry rich in phenolic compounds and anthocyanins, shows antioxidant and anti-inflammatory potential, but the instability and low bioavailability of these bioactive compounds limit their use, highlighting extraction and microencapsulation as preservation strategies. This study aimed to develop a spray-dried microencapsulated jabuticaba extract using maltodextrin as a carrier, while optimizing the extraction of phenolic compounds to enhance encapsulation efficiency and the retention of bioactive compounds. The peel and whole fruit were evaluated under different conditions (in natura, freeze-dried, oven-dried) to determine the most promising source of bioactive compounds. Extraction conditions included hydroethanolic solvents (50:50 and 80:20 v/v, acidified or non-acidified), solid concentrations (1%, 4%, and 15% w/v), and extraction times (2-24 h). The optimized extract was microencapsulated by spray drying using maltodextrin as the carrier. The freeze-dried peel showed higher phenolic recovery and antioxidant capacity than the whole fruit, with optimal extraction obtained using a 50:50 hydroethanolic solution and 2 h extraction. The extract showed high concentrations of phenolic compounds (62.38 ± 3.71 mg GAE/g), monomeric anthocyanins (11.63 ± 0.34 mg/g), and antioxidant capacity (DPPH: 14,017 ± 135 µmol Trolox/g); UPLC analysis identified cyanidin-3-glucoside (657.43 ± 2.93 mg/100 mL) and ellagic acid (71.17 ± 0.35 mg/100 mL) as the major phenolic compounds. The microencapsulated extract with maltodextrin presented low water activity (0.199 ± 0.014), spherical morphology, and retention of phenolic compounds. This study provides optimized extraction conditions and demonstrates the effectiveness of spray-drying microencapsulation using maltodextrin to stabilize jabuticaba phenolics, which may contribute to improving their stability and potential application as functional ingredients.Kelly Aparecida Dias; Lívya Alves Oliveira; Stephanie Michelin Santana Pereira; Valéria Silva de Lana; Júlia Francisquini D'Almeida; Izabela Maria Montezano de Carvalho; Hércia Stampini Duarte Martino; Ítalo Tuler Perrone; Elad Tako; Vitor L. Sanches; Mauricio Ariel Rostagno; Ceres Mattos Della Lúcia

Maltodextrin; Extraction (chemistry); Spray drying; Bioavailability; Antioxidant; Ellagic acid; Bioactive compound; Berry; High-performance liquid chromatography; Chemistry; Chromatography; Food science; Polyphenol; Antioxidant capacity; Food additive

2026-05-01https://doi.org/10.1111/1750-3841.71126Journal of Food Science 20261Efficacy and Safety of the L-Scar Technique in Breast Surgery: A Systematic Review and Meta-AnalysisAbstract Background The L-scar technique has emerged as a promising alternative in breast surgery, aiming to reduce visible scarring while preserving aesthetics and minimizing complications. Despite growing clinical interest, comprehensive evaluations of its outcomes remain scarce. Methods We conducted a systematic review and meta-analysis following PRISMA and Cochrane guidelines. Studies were included if they assessed the L-scar technique in breast procedures, including reduction mammaplasty, mastopexy and augmentation, and reported on postoperative complications or patient satisfaction. Searches were performed in PubMed, Embase, Scopus, Web of Science, and Cochrane through December 2024. Pooled prevalences were calculated using a random-effects model, and heterogeneity was assessed via the I 2 statistic. Risk of bias was evaluated using ROBINS-I. Results Twelve studies comprising 3,130 patients were included. The pooled incidence of complications was low across most outcomes: breast asymmetry (1.95%), dog-ear deformity (5%), scar hypertrophy (1.7%), wound dehiscence (1.8%), seroma (0.6%), hematoma (1.2%), infection (0.6%), fat necrosis (5.8%), partial nipple areolar complex (NAC) necrosis (0.4%), and no reported cases of complete NAC necrosis. Sensory complications included nipple sensation loss (2.2%) and reduction (20%). Patient satisfaction was high, with a pooled rate of 92%. All estimates include 95% confidence intervals. Heterogeneity was moderate to high for some outcomes, but sensitivity analyses confirmed the robustness of most estimates. Conclusions The L-scar technique demonstrates a favorable safety profile, minimal visible scarring, and excellent satisfaction rates. It appears to be a safe and effective option within the spectrum of contemporary breast reshaping techniques. Further prospective studies are warranted to validate long-term outcomes. Level of Evidence III This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .Pedro Lucas Machado Magalhães; Bernardo Gabriele Collaço; Milena Gonçalves Guerreiro; Anderson Matheus Pereira da Silva; Luciano Falcão; Dillan Cunha Amaral; Rafael Andrade Sampaio Silva; Mariana Letícia de Bastos Maximiano; Isabela Azevedo de Almeida; Yasmin Picanco Silva; Bernardo Gonçalves Bastian Pinto; Adekunle Elegbede

Breast reduction; Seroma; Mastopexy; Fat necrosis; Patient satisfaction; Wound dehiscence; Meta-analysis; Systematic review; Dehiscence; Breast surgery; Medicine; Surgery; Prospective cohort study; Mammaplasty; Plastic surgery; Breast augmentation; Hematoma; Breast cancer

2026-05-11https://doi.org/10.1007/s00266-026-05869-1Aesthetic Plastic Surgery 20261An OpenFOAM based solver for three-phase flow in porous media incorporating foam effectsFoam injection is a promising alternative for enhanced oil recovery strategies, as it can improve sweep efficiency in gas-assisted processes. Accurately predicting multiphase foam flow in porous media, however, remains challenging, and existing modeling approaches continue to evolve as new foam modeling insights and numerical strategies emerge. In this work, we develop ImpesFOAM, a computational framework for three-phase flow incorporating effects of foam using Finite volume method (FVM) formulation within the OpenFOAM framework and IMplicit-Pressure Explicit-Saturation (IMPES) method. Two foam formulations are incorporated: an implicit-texture model that captures dry-out, oil effects, and surfactant concentration, and a mechanistic population-balance model describing bubble generation and coalescence. Surfactant transport in the aqueous phase is modeled through an additional conservation equation that includes adsorption effects. The object-oriented high-level programming design of OpenFOAM facilitates the link between mathematical modeling and computational implementation, which makes the developed solver more flexible for further foam model implementations. The solver is validated against a comprehensive set of benchmark cases for two and three-phase flow, with and without foam, designed to isolate gravity, capillary pressure, well-driven flow with source and sink terms, and surfactant transport mechanisms. The results show good agreement with analytical, numerical, and experimental results. Moreover, through two three-dimensional field application cases, we demonstrate that foam-assisted Enhanced Oil Recovery (EOR) ultimately yields more economically attractive outcomes, including a substantial increase in oil recovery factor and a decrease in the gas-oil ratio production. Program summary Program Title: ImpesFoam3ph CPC Library link to program files: https://doi.org/10.17632/9h89bzphmr.1 Developer's repository link: https://github.com/UnderMou/impesFoam3ph.git Licensing provisions: GPLv3 Programming language: C++ Supplementary material: https://github.com/UnderMou/impesFoam3ph/blob/84b02b1f1609a997127a3f38795d30dafc9a0901/supp_mat/CPC_supplementary_materials.pdf Nature of problem: This software solves three-phase flow in porous media with foam effects. Solution method: The numerical approach is based on the finite-volume method (FVM) through OpenFOAM framework using the IMPES method to solve the pressure–saturation system.Anderson de Moura Ribeiro; Grigori Chapiro; Bernardo Martins Rocha; Rodrigo Weber dos Santos

Porous medium; Solver; Flow (mathematics); Porosity; Computational fluid dynamics; Mechanics; Materials science; Computer science; Physics

2026-05-14https://doi.org/10.1016/j.cpc.2026.110214Computer Physics Communications 20261Technological application diagram proposal: new approach to technological applications of milk protein concentrate in dairy products based on physicochemical characterization and applied statisticsCurrently, market demand indicates a trend towards the use of milk proteins in food products. Technological innovations in milk protein production have facilitated the development of new products that can be adapted to various food systems. Despite the growing use of milk protein concentrates (MPCs), much remains to be understood regarding how the interactions between these proteins can lead to a more cost-effective ratio and better utilization of their properties. Although a variety of MPCs are available in the market, the industry may face difficulties replacing one brand's product with another. This is because although the products have the same protein content, their production history can interfere with their technological properties. Therefore, the objective of this study was (a) to create a protocol for analyses that allows the segregation of MPCs based on their key characteristics and, using these results and statistical treatments, (b) to develop a diagram to guide the industry, research and development sectors, and/or procurement departments on the potential application of these products and even the possible substitution of one MPC for another. To this end, nine MPC brands were classified based on their rehydration capacity, browning potential, foaming ability and thermal stability. The results of each analysis were scored to generate a rating that classified the samples and enabled the creation of a technological application diagram.Carolina Neves Cunha; Caroline Barroso dos Anjos Pinto; Maria Esther Sad; Vitória Souza Lima; Júlia d'Almeida Francisquini; Igor Lima de Paula; Juliana de Carvalho da Costa; Rodrigo Stephani; Ítalo Tuler Perrone

Dairy industry; Production (economics); Product (mathematics); Food products; Characterization (materials science); Milk products; Variety (cybernetics); New product development; Biochemical engineering; Food science; Computer science; Biotechnology; Process engineering; Business; Procurement; Food industry; Milk protein

2026-05-18https://doi.org/10.1017/s0022029926102209Journal of Dairy Research 20261A Decision-Analytics Framework Combining DEA, SFA, and ML With Mixture Optimization for Industrial PhotovoltaicsThe rapid rollout of industrial photovoltaic (PV) generation demands robust tools for benchmarking performance and guiding investment. Traditional efficiency techniques – non-parametric data envelopment analysis (DEA) and parametric stochastic-frontier analysis (SFA) – offer complementary strengths, yet each has recognized limitations when applied in isolation. This study proposes a hybrid framework that (i) estimates multiple DEA and SFA frontiers; (ii) learns their predictive patterns with Random Forest, Gradient Boosting and XGBoost models; and (iii) integrates the resulting efficiency scores through an optimized weighting scheme derived from a simplex-lattice mixture design of experiments. The approach is demonstrated on a statewide dataset covering 70 immediate geographic regions of Minas Gerais, Brazil, comprising installed capacity, number of PV units, solar-radiation estimates and realized energy output. Optimization yields a parsimonious composite based primarily on the DEA and SFA models, reducing the principal-component loss metric by 18 % relative to equal weighting. Spatial analysis reveals a clear north–south efficiency gradient correlated with solar insolation; nonetheless, centrally located industrial hubs also achieve high scores, underscoring the moderating role of infrastructure. The findings highlight regions where policy support or technology upgrades could deliver the greatest marginal gains and illustrate how mixture-design optimization can reconcile diverse frontier estimates, offering a generalizable decision-analytics toolkit for renewable-energy assessment.Gustavo S. Leal; Victor E.M. Valério; Pedro P. Balestrassi; Lupercio F. Bessegato; Farid Melgani

Mixture model; Photovoltaics; Work (physics); Production (economics); Quality (philosophy); Process engineering; Materials science; Computer science

2026-01-01https://doi.org/10.1109/oajpe.2026.3694970IEEE Open Access Journal of Power and Energy 20261Global burden of enteric infectious diseases, diarrhoeal diseases, and corresponding aetiologies, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023Avina Vongpradith; Regina-Mae Villanueva Dominguez; Lorainne Tudor Car; Amanda Movo; Samuel M Ostroff; Jiawei He; Samuel B Albertson; Austin Carter; Catherine Bisignano; Bhoomadevi A; Hasan Aalruz; Belayneh Jejaw Abate; Madineh Abbasi; Samar Abd ElHafeez; Emad M. Abdallah; Abdelmuhsin Abdelgadir; Ahmed A. Abdelgalil; Reda Abdel-Hameed; Ahmed AH Abdellatif; Omar Ahmed Abdelwahab; Siddig İbrahim Abdelwahab; Wakgari Mosisa Abdisa; Arman Abdous; Jeza Muhamad Abdul Aziz; Rashad Abdul-Ghani; Abdulbasit Sherfa Abduljelil; Rizwan Suliankatchi Abdulkader; Abdullah; Auwal Abdullahi; Abdulrakib Abdulrahim; Rezheen Fatah Abdulrahman; Zirak Ahmed Abdulrahman; Toufik Abdul‐Rahman; Sadik Abdulwehab; Kulmira Abdykerimova; Meklit Girma Abebe; Abiy Abebe; Asrat Agalu Abejew; Yirgalem Abere; Syed Hani Abidi; Olifan Zewdie Abil; Olumide Abiodun; Richard Gyan Aboagye; Hassan Abolhassani; Abdullahi Tunde Aborode; Nagah M Abourashed; Dariush Abtahi; Amr S. Abu Lila; Fuad Hamdi A Abuadas; Alqassem H Abuarqoub; Nermeen Abu-Elala; Rana Kamal Abu-Farha; Eman Abu-Gharbieh; Sawsan Abuhammad; Ahmad Y. Abuhelwa; Hana J Abukhadijah; Dina Abushanab; Anirudh B. Acharya; Krishna Prasad Acharya; Swetha Acharya; Lisa C Adams; Abdu A. Adamu; Aishah Fadila Adamu; Yau Adamu; Isaac Yeboah Addo; Tajudeen Adesanmi Adebisi; Babatope O. Adebiyi; Ayo Stephen Adebowale; O. A. LAWAL Adebowale; David Adedia; Kamoru A. Adedokun; Oluwatobi E Adegbile; Nurudeen A Adegoke; Victor Adekanmbi; Saheed Ayodeji Adekola; Olumide Thomas Adeleke; Makinde Adebayo Adeniyi; Adedeji Adenusi; Adekola George Adepoju; Daniel Adeyemi Adepoju; Rofiat Adewumi Adewumi Aderinoye-Rabiu; Charles Oluwaseun Adetunji; Ripon Kumar Adhikary; Usha Adiga; Molalign Aligaz Aligaz Adisu; Belete Muluadam Admassie; Kalkidan Yibeltal Admassu; Mohd Adnan; Qorinah Estiningtyas Sakilah Adnani; Obed Adonteng-Kissi; Ebenezer Afrifa-Yamoah; Muhammad Sohail Afzal; Saira Afzal; Shairyar Afzal; Victor Ibukun Agbajelola; Zeleke Dutamo Agde; Navidha Aggarwal; Feleke Doyore Agide; Percival Delali Delali Agordoh; Piyush Agrawal

Burden of disease; Diarrhoeal disease; Disease burden; Disease; Diarrhea; Double burden; Global health; Medicine; Environmental health; Epidemiology

2026-06-01https://doi.org/10.1016/s1473-3099(26)00194-5The Lancet Infectious Diseases 20261Cosmin reporting guideline for studies on measurement properties of patient-reported outcome measures and its explanation and elaboration document: translation into Brazilian PortuguesePURPOSE: The COSMIN Reporting Guideline 2.0 and its Explanation & Elaboration document have been published to guide researchers in reporting studies on measurement properties of patient-reported outcome measures (PROMs). We aimed to translate the COSMIN Reporting Guideline 2.0 and its Explanation & Elaboration document to report studies on measurement properties of PROMs into Brazilian Portuguese. METHODS: We followed an adapted four-step methodology, including artificial intelligence (AI) forward-translation and back-translation, and appraisal of all written reports by the developers/committee. RESULTS: The AI produced uncommon terms, later standardized to usual Brazilian Portuguese expressions. Back-translation showed minor discrepancies without altering meaning. Expert review corrected grammar and refined terminology. CONCLUSION: The COSMIN Reporting Guideline 2.0 and its Explanation & Elaboration document have been translated into Brazilian Portuguese and can overcome language barriers and guide Brazilian-speaking researchers, clinicians, patients, and policymakers in reporting studies on measurement properties of PROMs. Both documents are available on the COSMIN website.Guilherme Tavares de Arruda; Caroline B. Terwee; Patrícia Driusso; Mariana Arias Ávila; Lidwine B. Mokkink

Elaboration; Guideline; Portuguese; Brazilian Portuguese; Grammar; European Portuguese; Psychology; Applied psychology; Medical education; Outcome (game theory); Linguistics

2026-06-05https://doi.org/10.1007/s11136-026-04282-0Quality of Life Research 20261PARC: proactive protocol for routing in wireless optical ad hoc networksAbstract The expected growth in the number of connected devices, together with the spectrum crunch in overcrowded radio bands, motivates the exploration of complementary wireless technologies. Optical Wireless Communication (OWC), including visible light systems, provides a vast unlicensed spectrum but introduces unique networking challenges: strong directionality, line-of-sight requirements, sensitivity to shadowing, and fast link intermittency due to mobility. This paper presents PARC ( Proactive and Adaptive Routing Control ), a proactive routing protocol designed specifically for light-based ad hoc networks (LANETs). PARC combines proactive topology dissemination with link-quality-aware route selection and adaptive control mechanisms. We evaluate PARC in ns-3 OWC scenarios ranging from static baselines to highly dynamic and high-density settings, including an additional extended stress-test with simultaneous mobility and full traffic load. Overall, PARC sustains significantly higher packet delivery and throughput than the OLSR reference protocol under challenging conditions.André Luiz Barros Vieira Júnior; Luiz F. M. Vieira; Luiz F. M. Vieira; Marcos A. M. Vieira; Alex B. Vieira; Alex B. Vieira; José Augusto M. Nacif

Optimized Link State Routing Protocol; Wireless Routing Protocol; Routing protocol; Wireless ad hoc network; Ad hoc wireless distribution service; Zone Routing Protocol; Dynamic Source Routing; Link-state routing protocol; Computer network; Computer science; Distributed computing; Throughput; Vehicular ad hoc network; Mobile ad hoc network; Network packet; Adaptive quality of service multi-hop routing; Routing (electronic design automation)

2026-06-12https://doi.org/10.1007/s12243-026-01190-9Annals of Telecommunications 20261Low-cost powered mobility devices for early mobility training in children with neurodevelopmental disorders: a case seriesOBJECTIVE: This prospective case series explored the feasibility and potential functional effects of a low-cost powered mobility device integrated into a physiotherapy training program on participation, trunk control, and quality of life in children with neurodevelopmental disorders. METHODS: Five children aged 4-11 years with limited independent mobility due to neurodevelopmental conditions completed an eight-week training program using a low-cost powered mobility device. Weekly 45-minute sessions focused on joystick use, directional control, and task-oriented navigation. Outcomes included participation (YC-PEM/PEM-CY), trunk control (TCMS), health-related quality of life (PedsQL 4.0), powered mobility learning (ALP 2.0), and user satisfaction (QUEST 2.0), assessed before and after intervention. RESULTS: All participants successfully operated the device and improved powered mobility skills (ALP 2.0: +2.20 ± 0.84). Trunk control improved in most children (TCMS: +6.8 ± 4.4), with variability related to functional abilities and support needs. Participation increased across home, school, and community settings, while the desire for change decreased. Health-related quality of life improved (PedsQL 4.0: +15 ± 13.8), and families reported high satisfaction (QUEST 2.0: 4.46 ± 0.55). CONCLUSIONS: The low-cost powered mobility devices integrated into structured physiotherapy training programmes are feasible and may support participation, environmental exploration, quality of life, powered mobility learning, and opportunities for environmental exploration in children with limited independent mobility. Affordable powered mobility technologies may expand early access to assistive mobility solutions and support functional participation in paediatric physiotherapy contexts.S. Balsategui-Gil; Concepción Soto-Vidal; Paula Silva de Carvalho Chagas; Saturnino Maldonado-Bascón; P. Alba-Díaz; Soraya Pacheco‐da‐Costa

Training (meteorology); Series (stratigraphy); Activities of daily living; Rehabilitation; Limited mobility; Physical medicine and rehabilitation; Psychology; Computer science; Medicine

2026-06-16https://doi.org/10.1080/17483107.2026.2685884Disability and Rehabilitation Assistive Technology 20261Impact of Anatomical Positioning Markers on Breast Cancer Detection ThermographyJoão Augusto Pilato de Castro; Fabrício Araújo Filgueiras; Luíza Machado Costa Nascimento; Heder S. Bernardino; Saulo Moraes Villela

Thermography; Discriminative model; Breast cancer; Noise (video); Segmentation; Focus (optics); Displacement (psychology); Pattern recognition (psychology); Computer science; Artificial intelligence; Computer vision; Image segmentation; Image processing; Mammography

2026-06-30https://doi.org/10.1007/978-3-032-30488-9_8Lecture notes in computer science 20261Machine Learning Enhanced Prediction of TDS for Strengthening Aquatic Disease Early Warning SystemsAbdullah Al Mamun Hridoy; Paolo Pastorino; Chiara Bordin; Leonardo Goliatt; Petra Schneider; Abdullah Ibna Shawkat; Mohd. Saifur Rahman; Minhaj Uddin; Matteo Bodini; Pakorn Ditthakit; Md. Abdullah Al Mamun; Brunoda Silva Macêdo

Ensemble learning; Multilayer perceptron; Hyperparameter; Artificial neural network; Feature selection; Mean squared error; Random forest; Perceptron; Ensemble forecasting; Calibration; Machine learning; Artificial intelligence; Computer science; Early warning system; Water quality; Warning system; Decision tree; Statistics; Predictive modelling; Regression; Feature (linguistics); Data mining; Stability (learning theory); Linear regression; Range (aeronautics); Regression analysis; Aquatic ecosystem

2026-02-11https://doi.org/10.21203/rs.3.rs-8199017/v1Research Square 20261Author Correction: Global, regional, and national burden of chronic respiratory diseases and impact of the COVID-19 pandemic, 1990–2023: a Global Burden of Disease studyJiyeon Oh; Soeun Kim; Yesol Yim; M S Kim; GBD 2023 Global Chronic Respiratory Disease and Covid Collaborators; Jae Il Shin; Ahmed A. J. Jabbar; Hasan Aalruz; Mohammadreza Abbasian; Abdallah H A Abd Al Magied; Samar Abd ElHafeez; Atef Ben Abdelkader; Mawada Hassan Abdelmagied; Parsa Abdi; Mohammad‐Amin Abdollahifar; Deldar Morad Abdulah; Auwal Abdullahi; Nigusie Abebaw; Roberto Ariel Abeldaño Zúñiga; Richard Gyan Aboagye; Hassan Abolhassani; Mohamed Abouzid; L.M.P. Abreu; Dariush Abtahi; Rana Kamal Abu Farha; Ibrahim Jatau Abubakar; Eman Abu-Gharbieh; H. Abukhadijah; Salahdein Aburuz; Ahmed Abu-Zaid; Juan Manuel Acuna; Mesafint Molla Adane; Isaac Yeboah Addo; Oyelola A. Adegboye; Victor Adekanmbi; Charles Oluwaseun Adetunji; Temitayo Esther Adeyeoluwa; Rishan Adha; Kishor Adhikari; Ripon Kumar Adhikary; Qorinah Estiningtyas Sakilah Adnani; Aanuoluwapo Adeyimika Afolabi; Rotimi Felix Afolabi; Fatemeh Afrashteh; Arya Afrooghe; Anurag Agrawal; Williams Agyemang-Duah; Aqeel Ahmad; Muayyad M Ahmad; Sajjad Ahmad; Shahzaib Ahmad; Ali Ahmadi; Ayman Ahmed; Haroon Ahmed; İbrar Ahmed; Mohammed Ahmed; Oli Ahmed; Sindew Mahmud Ahmed; Syed Anees Ahmed; Abdullateef Abiodun Ajadi; Ruslan Akhmedullin; Karolina Akinosoglou; Mohammed Ahmed Al-kaif; Ashley E Akrami; Hanadi Al Hamad; Syed Mahfuz Al Hasan; Muaaz M. Alajlani; Yazan A. Al-Ajlouni; Khurshid Alam; Mohammad Khursheed Alam; Nazmul Alam; Rasmieh Mustafa Al-amer; Ayman A. Al-Eyadhy; Abdelazeem M. Algammal; Adel Ali Saeed Al-Gheethi; Fadwa Naji Alhalaiqa; Endale Alemayehu Ali; Mohammad Daud Ali; Mohammed Usman Ali; Rafat Ali; Syed Shujait Ali; Waad Ali; Akram Al-Ibraheem; Sheikh Mohammad Alif; Samah W. Al-Jabi; Mohamad Aljofan; Syed Mohamed Aljunid; Sabah Al-Marwani; Hesham M. Al-Mekhlafi; Mohmmad Minwer Alnaeem; Mahmoud A. Alomari; Jaber S. Alqahtani; Abdullah A. Alqarni; Ahmad Alrawashdeh; Sahel Majed Alrousan; Mohammed Alsabri; Najim Alshahrani; Zaid Altaany; A. Altaf; Khaled Altartoor

Asthma; Pandemic; Incidence (geometry); Burden of disease; Respiratory system; Mortality rate; Disease burden; Medicine; Demography; Disease; Respiratory disease; Chronic disease; Coronavirus disease 2019 (COVID-19); Environmental health; Cause of death; Pediatrics

2026-03-01https://doi.org/10.1038/s41591-026-04288-8Nature Medicine 20261No-local-broadcasting theorem for nonsignaling behaviors and assemblagesThe no-broadcasting theorem is a fundamental result in quantum information theory. It guarantees that a class of attacks on quantum protocols, based on eavesdropping and indiscriminate copying of quantum information, are impossible. Due to its fundamental importance, it is natural to ask whether it is an intrinsic quantum property or whether it also holds for a broader class of non-classical theories. To address this question, one could use the framework of correlation scenarios. Under this standpoint, Joshi, Grudka, and the Horodeckis conjectured that one cannot locally broadcast nonlocal behaviours. In this paper, we prove their conjecture based on the monotonicity of the relative entropy for behaviours. Additionally, following a similar reasoning, we obtain an analogous no-go theorem for steerable assemblages.Adrian Solymos; Carlos Vieira; Cristhiano Duarte; Zoltán Zimborás

Eavesdropping; Conjecture; Quantum; Computer science; Generalization; Class (philosophy); Property (philosophy); Multipartite; Copying; Mathematics; Theoretical physics; Discrete mathematics; Pure mathematics; Mathematical economics; Theoretical computer science; Computer security; Quantum mechanics; Physics; Epistemology; Law; Philosophy; Quantum entanglement; Political science

2026-02-03https://doi.org/10.1103/q5gp-yjkdPhysical Review A 20261Development and performance evaluation of a UV-C coupled recirculation system for enhancing cistern water microbiological quality<title>Abstract</title> In semi-arid regions, the absence of adequate water treatment for human consumption frequently gives rise to intestinal disorders and, in more severe cases, severe microbial infections. Within the context of the semi-arid region, many households depend on cistern water for their potable needs. This project aimed to develop and use a system composed of a UV-C radiation-emitting lamp coupled to a water recirculation pump to ensure the bacteriological safety of cistern water. The recirculation system was operated for 6, 12, and 24 hours, and tests were conducted using environmental samples or with <italic>E. coli</italic> ATCC 25922. The results demonstrated that the system could achieve 100% inhibition of the growth of total coliforms and thermotolerant coliforms after 6 hours of operation. The low-cost system has the potential to function as a social technology, thereby ensuring water security in semi-arid regions where there is no public water distribution system.Jardielen Chaves Sousa; Adelaide Sampaio Oliveira; Dionéia Evangelista Cesar; Camila Portela Silva; Edmo Montes Rodrigues

Cistern; Quality (philosophy); Environmental science; Water quality; Petroleum engineering; Environmental engineering; Engineering; Physics; Biology; Ecology; Geography

2026-01-01https://doi.org/10.1590/s1413-415220250132Engenharia Sanitaria e Ambiental 20261Search for heavy neutral leptons in decays of W bosons produced in 13 TeV pp collisions using prompt signatures in the ATLAS detectorAbstract The existence of right-handed neutrinos with Majorana masses below the electroweak scale could help address the origins of neutrino masses, the matter–antimatter asymmetry, and dark matter. In this paper, leptonic decays of W bosons from 140 fb $$^{-1}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mmultiscripts> <mml:mrow/> <mml:mrow/> <mml:mrow> <mml:mo>-</mml:mo> <mml:mn>1</mml:mn> </mml:mrow> </mml:mmultiscripts> </mml:math> of 13 TeV proton–proton collisions at the LHC, reconstructed in the ATLAS experiment, are used to search for heavy neutral leptons produced through their mixing with muon or electron neutrinos in a scenario with lepton number violation. The search is conducted using prompt leptonic decay signatures. The considered final states require two same-charge leptons or three leptons, while vetoing three-lepton same-flavour topologies. No significant excess over the expected Standard Model backgrounds is found, leading to constraints on the heavy neutral lepton’s mixing with muon and electron neutrinos for heavy-neutral-lepton masses. The analysis excludes $$|U_{e}|^2$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:mrow> <mml:mo>|</mml:mo> </mml:mrow> <mml:msub> <mml:mi>U</mml:mi> <mml:mi>e</mml:mi> </mml:msub> <mml:msup> <mml:mrow> <mml:mo>|</mml:mo> </mml:mrow> <mml:mn>2</mml:mn> </mml:msup> </mml:mrow> </mml:math> values above $$8\times 10^{-5}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:mn>8</mml:mn> <mml:mo>×</mml:mo> <mml:msup> <mml:mn>10</mml:mn> <mml:mrow> <mml:mo>-</mml:mo> <mml:mn>5</mml:mn> </mml:mrow> </mml:msup> </mml:mrow> </mml:math> and $$|U_{\mu }|^2$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:mrow> <mml:mo>|</mml:mo> </mml:mrow> <mml:msub> <mml:mi>U</mml:mi> <mml:mi>μ</mml:mi> </mml:msub> <mml:msup> <mml:mrow> <mml:mo>|</mml:mo> </mml:mrow> <mml:mn>2</mml:mn> </mml:msup> </mml:mrow> </mml:math> values above $$5.0 \times 10^{-5}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:mn>5.0</mml:mn> <mml:mo>×</mml:mo> <mml:msup> <mml:mn>10</mml:mn> <mml:mrow> <mml:mo>-</mml:mo> <mml:mn>5</mml:mn> </mml:mrow> </mml:msup> </mml:mrow> </mml:math> in the full mass range of 8–65 GeV. The strongest constraints are placed on heavy-neutral-lepton masses in the range 15–30 GeV of $$|U_{e}|^2 < 1.1 \times 10^{-5}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:mrow> <mml:mo>|</mml:mo> </mml:mrow> <mml:msub> <mml:mi>U</mml:mi> <mml:mi>e</mml:mi> </mml:msub> <mml:msup> <mml:mrow> <mml:mo>|</mml:mo> </mml:mrow> <mml:mn>2</mml:mn> </mml:msup> <mml:mo><</mml:mo> <mml:mn>1.1</mml:mn> <mml:mo>×</mml:mo> <mml:msup> <mml:mn>10</mml:mn> <mml:mrow> <mml:mo>-</mml:mo> <mml:mn>5</mml:mn> </mml:mrow> </mml:msup> </mml:mrow> </mml:math> and $$|U_{\mu }|^2 < 5 \times 10^{-6}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:mrow> <mml:mo>|</mml:mo> </mml:mrow> <mml:msub> <mml:mi>U</mml:mi> <mml:mi>μ</mml:mi> </mml:msub> <mml:msup> <mml:mrow> <mml:mo>|</mml:mo> </mml:mrow> <mml:mn>2</mml:mn> </mml:msup> <mml:mo><</mml:mo> <mml:mn>5</mml:mn> <mml:mo>×</mml:mo> <mml:msup> <mml:mn>10</mml:mn> <mml:mrow> <mml:mo>-</mml:mo> <mml:mn>6</mml:mn> </mml:mrow> </mml:msup> </mml:mrow> </mml:math> .G. Aad; Erlend Aakvaag; B. Abbott; Sara Abdelhameed; Kira Abeling; Nils Julius Abicht; S. H. Abidi; Mohammed Aboelela; A. Aboulhorma; H. Abramowicz; Yiming Abulaiti; B. S. Acharya; Anke Ackermann; C. Adam Bourdarios; L. Adamczyk; Sagar Addepalli; Matthew John Addison; J. Adelman; Aytul Adiguzel; T. Adye; A. A. Affolder; Y. Afik; M. N. Agaras; A. Aggarwal; C. Agheorghiesei; F. Ahmadov; S. Ahuja; X. Ai; X. Ai; A. Aikot; M. Ait Tamlihat; B. Aitbenchikh; M. Akbiyik; T. P. A. Åkesson; A. V. Akimov; D. Akiyama; Nilima Nilesh Akolkar; S. Aktas; G. L. Alberghi; J. Albert; J. Albert; P. Albicocco; Guillaume Lucas Albouy; S. Alderweireldt; Z. L. Alegria; M. Aleksa; Martin Aleksa; C. Alexa; T. Alexopoulos; F. Alfonsi; M. Algren; M. Alhroob; B. Ali; B. Ali; Hanadi Ali; S. Ali; M. Aliev; G. Alimonti; W. Alkakhi; C. Allaire; B. M. M. Allbrooke; Jonny Allen; Jonny Allen; P. P. Allport; A. Aloisio; F. Alonso; C. Alpigiani; Zainab Mohammad K Alsolami; A. Álvarez Fernández; Mario Alves Cardoso; M. G. Alviggi; M. Aly; Y. Amaral Coutinho; A. Ambler; C. Amelung; Christoph Amelung; C. G. Ames; Thiziri Amezza; D. Amidei; Baktash Amini; Kyle Amirie; Artem Amirkhanov; S. P. Amor Dos Santos; K. R. Amos; Dimitra Amperiadou; S. An; Shiwen An; T. Andeen; J. K. Anders; J. K. Anders; A. Andreazza; S. Angelidakis; A. Angerami; A. V. Anisenkov; A. Annovi; C. Antel; E. Antipov; M. Antonelli; F. Anulli; M. Aoki

Lepton; Muon; Neutrino; Electroweak interaction; Boson; MAJORANA; Lepton number; Electroweak scale; Atlas (anatomy); Physics; Particle physics; Nuclear physics; Standard Model (mathematical formulation); ATLAS experiment; Atlas detector; Elementary particle; Electron; Dark matter; Physics beyond the Standard Model; Sterile neutrino; Large Hadron Collider; Particle decay

2026-02-14https://doi.org/10.1140/epjc/s10052-025-15191-wThe European Physical Journal C 20261Tuberculous Chronic Prostatitis: a Neglected DiseaseAn interesting and timely review on prostatitis was recently published in JAMA by Borget et al. (1).However, an important omission must be highlighted: tuberculous chronic prostatitis.In the review, tuberculosis is mentioned only once, under the "Epidemiology and Risk Factors" section of chronic bacterial prostatitis: "Risk factors for chronic bacterial prostatitis include prior acute bacterial prostatitis, urethral surgery or catheterization, urinary stasis, unprotected anal intercourse, and genitourinary tuberculosis." This limited reference has also been observed in other reviews and guidelines, underscoring that tuberculous chronic prostatitis remains a neglected condition (2).Nearly 90% of new tuberculosis cases occur in 30 countries, including Brazil and 29 countries in Africa and Asia.Nevertheless, due to migration and globalization, tuberculosis must be regarded as a worldwide health concern.Urogenital tuberculosis, and specifically prostatic involvement, though uncommon in developed countries, has been documented globally (3).Importantly, Mycobacterium tuberculosis is a treatable cause of chronic prostatitis and is underdiagnosed rather than rare.In Russia, Kulchavenya et al. followed a cohort of 73 patients with chronic prostatitis for at least two years, diagnosing tuberculous prostatitis in 17 patients (23.3%).This included 2 cases (11.8%) initially classified as nonbacterial chronic prostatitis and 15 cases (88.2%) classified as bacterial chronic prostatitis (4).More recently, our group in Brazil published in this journal a qualitative study analyzing 18 patients with prostatic tuberculosis (5).In 10 patients (55.6%), the presentation was chronic prostatitis, either recurrent (2 patients) or persistent with sterile pyuria (8 patients).All patients achieved pain resolution with pharmacological treatment.Notably, 6 patients were diagnosed within one year, coinciding with the implementation of systematic tuberculosis screening for all chronic prostatitis cases.Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) substantially impairs quality of life and remains therapeutically challenging.However, CP/CPPS is also a clinical manifestation of prostatic tuberculosis and may be effectively treated when recognized.Therefore, reviews and guidelines on prostatitis should emphasize that: Patients with CP/CPPS must be systematically screened for tuberculosis using culture and nucleic acid amplification testing of urine and semen.André Avarese de Figueiredo; Augusto de Azevedo Barreto; Victor Silvestre Soares Fanni

Disease; Tuberculosis; MEDLINE; Population; Incidence (geometry); Medicine; Intensive care medicine

2026-04-01https://doi.org/10.1590/s1677-5538.ibju.2025.0521International braz j urol 20261Measurement of the W-boson angular coefficients and transverse momentum in $$p\!p$$ collisions at $$\sqrt{s}=13$$ TeV with the ATLAS detectorAbstract The angular distributions of Drell–Yan lepton pairs provide sensitive probes of the underlying dynamics of quantum chromodynamics (QCD) effects in vector-boson production. This paper presents for the first time the measurement of the full set of angular coefficients together with the differential cross-section as a function of the transverse momentum of the W boson, in the full phase space of the decay leptons. The measurements are performed separately for the $$W^-$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msup> <mml:mi>W</mml:mi> <mml:mo>-</mml:mo> </mml:msup> </mml:math> and $$W^+$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msup> <mml:mi>W</mml:mi> <mml:mo>+</mml:mo> </mml:msup> </mml:math> channels. The analysis uses proton–proton collision data recorded by the ATLAS experiment at the Large Hadron Collider in 2017 and 2018, during special low-luminosity runs with a reduced number of interactions per bunch crossings (pile-up). The data correspond to an integrated luminosity of 338 pb $$^{-1}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mmultiscripts> <mml:mrow/> <mml:mrow/> <mml:mrow> <mml:mo>-</mml:mo> <mml:mn>1</mml:mn> </mml:mrow> </mml:mmultiscripts> </mml:math> at a centre-of-mass energy of $$\sqrt{s} = 13$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:msqrt> <mml:mi>s</mml:mi> </mml:msqrt> <mml:mo>=</mml:mo> <mml:mn>13</mml:mn> </mml:mrow> </mml:math> TeV. The low pile-up environment provides excellent experimental conditions for high-precision measurements of W -boson production. All results agree with theoretical predictions incorporating finite-order QCD corrections up to order $$\alpha _S^2$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msubsup> <mml:mi>α</mml:mi> <mml:mi>S</mml:mi> <mml:mn>2</mml:mn> </mml:msubsup> </mml:math> .G. Aad; E. Aakvaag; B. Abbott; S. Abdelhameed; K. Abeling; N. J. Abicht; S. H. Abidi; M. Aboelela; A. Aboulhorma; H. Abramowicz; Y. Abulaiti; B. S. Acharya; A. Ackermann; C. Adam Bourdarios; L. Adamczyk; S. V. Addepalli; M. J. Addison; J. Adelman; A. Adiguzel; T. Adye; A. A. Affolder; Y. Afik; M. N. Agaras; A. Aggarwal; C. Agheorghiesei; F. Ahmadov; S. Ahuja; S. Ahuja; X. Ai; G. Aielli; A. Aikot; M. Ait Tamlihat; B. Aitbenchikh; M. Akbiyik; T. P. A. Åkesson; A. V. Akimov; D. Akiyama; N. N. Akolkar; S. Aktas; G. L. Alberghi; J. Albert; U. Alberti; P. Albicocco; G. L. Albouy; S. Alderweireldt; Z. L. Alegria; M. Aleksa; I. N. Aleksandrov; C. Alexa; T. Alexopoulos; F. Alfonsi; M. Algren; M. Alhroob; B. Ali; H. M. J. Ali; S. Ali; S. W. Alibocus; M. Aliev; G. Alimonti; W. Alkakhi; C. Allaire; B. M. M. Allbrooke; D. R. Allen; J. S. Allen; J. F. Allen; P. P. Allport; A. Aloisio; F. Alonso; C. Alpigiani; Z. M. K. Alsolami; A. Alvarez Fernandez; M. Alves Cardoso; M. G. Alviggi; M. Aly; Y. Amaral Coutinho; A. Ambler; C. Amelung; M. Amerl; C. G. Ames; T. Amezza; D. Amidei; B. Amini; K. Amirie; A. Amirkhanov; S. P. Amor Dos Santos; K. R. Amos; D. Amperiadou; S. An; C. Anastopoulos; T. Andeen; J. K. Anders; A. C. Anderson; A. Andreazza; S. Angelidakis; A. Angerami; A. V. Anisenkov; A. Annovi; C. Antel; E. Antipov; M. Antonelli

Quantum chromodynamics; Large Hadron Collider; Transverse plane; Atlas (anatomy); Collision; Phase space; Hadron; Detector; Boson; Physics; Particle physics; Nuclear physics; Lepton; Luminosity; Atlas detector; ATLAS experiment; Collider; Coupling (piping); Compact Muon Solenoid; Photon; Standard Model (mathematical formulation); Angular momentum

2026-05-06https://doi.org/10.1140/epjc/s10052-025-15264-wThe European Physical Journal C 20261Six-dimensional cosmological models with conformal extensionsAbstract We consider the background cosmological solutions in the 6 D (six-dimensional) model with one time and five space coordinates. The theory of our interest has the action composed by the Einstein term, cosmological constant, and two conformal terms constructed from the third powers of the Weyl tensor. It is shown how the highest derivative terms in the equations of motion can be isolated that opens the way for their numerical integration. There are flat anisotropic solutions which make one of the flat isotropic subspaces to be static. Depending on the value of bare cosmological constant, either two-dimensional or three-dimensional subspace can be static. In particular, there is a physically favorable solution with three “large” space coordinates and two extra inner dimensions stabilized. This solution is stable for a wide range of coupling constants, but this requires a special value of the bare cosmological constant.Daniel Müller; S. G. Rubin; Ilya Shapiro; A. V. Toporensky

Conformal map; Linear subspace; Action (physics); Subspace topology; Cosmological constant; Isotropy; Space (punctuation); Einstein; Coupling (piping); Equations of motion; Physics; Theoretical physics; Mathematical physics; Motion (physics); Conformal symmetry; Metric expansion of space; Classical mechanics; Dimension (graph theory); Perfect Cosmological Principle; Cosmological model; Manifold (fluid mechanics); Geodesic; Cosmology; Anisotropy; Spacetime; Friedmann–Lemaître–Robertson–Walker metric; Range (aeronautics)

2026-05-01https://doi.org/10.1007/s10714-026-03556-9General Relativity and Gravitation 20261Search for electroweak <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"> <mml:mi>t</mml:mi> <mml:mover accent="true"> <mml:mi>t</mml:mi> <mml:mo stretchy="false">¯</mml:mo> </mml:mover> <mml:mi>W</mml:mi> <mml:mi>j</mml:mi> </mml:math> production in multileptonic final states at <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"> <mml:msqrt> <mml:mi>s</mml:mi> </mml:msqrt> <mml:mo>=</mml:mo> <mml:mn>13</mml:mn> <mml:mtext> </mml:mtext> <mml:mtext> </mml:mtext> <mml:mi>TeV</mml:mi> </mml:math> with the ATLAS detector and bounds on effective field theory operatorsA search is presented for the electroweak production of a top-quark pair in association with a <a:math xmlns:a="http://www.w3.org/1998/Math/MathML" display="inline"> <a:mi>W</a:mi> </a:math> boson and at least one additional jet known as the <c:math xmlns:c="http://www.w3.org/1998/Math/MathML" display="inline"> <c:mi>t</c:mi> <c:mover accent="true"> <c:mi>t</c:mi> <c:mo stretchy="false">¯</c:mo> </c:mover> <c:mi>W</c:mi> <c:msub> <c:mi>j</c:mi> <c:mi>EW</c:mi> </c:msub> </c:math> process. This process has embedded within it a <g:math xmlns:g="http://www.w3.org/1998/Math/MathML" display="inline"> <g:mi>t</g:mi> <g:mi>W</g:mi> </g:math> -scattering vertex, which is probed directly for the first time. The collision data were collected with the ATLAS detector during Run 2 of the LHC and correspond to an integrated luminosity of <i:math xmlns:i="http://www.w3.org/1998/Math/MathML" display="inline"> <i:mn>140</i:mn> <i:mtext> </i:mtext> <i:mtext> </i:mtext> <i:msup> <i:mi>fb</i:mi> <i:mrow> <i:mo>−</i:mo> <i:mn>1</i:mn> </i:mrow> </i:msup> </i:math> at <k:math xmlns:k="http://www.w3.org/1998/Math/MathML" display="inline"> <k:msqrt> <k:mi>s</k:mi> </k:msqrt> <k:mo>=</k:mo> <k:mn>13</k:mn> <k:mtext> </k:mtext> <k:mtext> </k:mtext> <k:mi>TeV</k:mi> </k:math> . The search uses same-charge pairs of electrons and muons together with jets, of which at least one is <m:math xmlns:m="http://www.w3.org/1998/Math/MathML" display="inline"> <m:mi>b</m:mi> </m:math> -tagged. The properties of the most forward jet relative to the rest of the event are used to discriminate the electroweak <o:math xmlns:o="http://www.w3.org/1998/Math/MathML" display="inline"> <o:mi>t</o:mi> <o:mover accent="true"> <o:mi>t</o:mi> <o:mo stretchy="false">¯</o:mo> </o:mover> <o:mi>W</o:mi> <o:msub> <o:mi>j</o:mi> <o:mi>EW</o:mi> </o:msub> </o:math> production process from its strong <s:math xmlns:s="http://www.w3.org/1998/Math/MathML" display="inline"> <s:mi>t</s:mi> <s:mover accent="true"> <s:mi>t</s:mi> <s:mo stretchy="false">¯</s:mo> </s:mover> <s:mi>W</s:mi> </s:math> production counterpart. A measured (expected) 95% CL upper limit on the cross section is set at <w:math xmlns:w="http://www.w3.org/1998/Math/MathML" display="inline"> <w:msub> <w:mi>σ</w:mi> <w:mrow> <w:mi>t</w:mi> <w:mover accent="true"> <w:mi>t</w:mi> <w:mo stretchy="false">¯</w:mo> </w:mover> <w:mi>W</w:mi> <w:msub> <w:mi>j</w:mi> <w:mi>EW</w:mi> </w:msub> </w:mrow> </w:msub> <w:mo><</w:mo> <w:mn>251</w:mn> <w:mtext> </w:mtext> <w:mtext> </w:mtext> <w:mi>fb</w:mi> </w:math> (230 fb), to be compared with the expected Standard Model (SM) cross section of 47.7 fb. Limits are set on the SM effective field theory (EFT) operators <ab:math xmlns:ab="http://www.w3.org/1998/Math/MathML" display="inline"> <ab:msub> <ab:mi>O</ab:mi> <ab:mrow> <ab:mi>H</ab:mi> <ab:mi>t</ab:mi> </ab:mrow> </ab:msub> </ab:math> and <cb:math xmlns:cb="http://www.w3.org/1998/Math/MathML" display="inline"> <cb:msubsup> <cb:mi>O</cb:mi> <cb:mrow> <cb:mi>H</cb:mi> <cb:mi>Q</cb:mi> </cb:mrow> <cb:mrow> <cb:mo stretchy="false">(</cb:mo> <cb:mn>1</cb:mn> <cb:mo stretchy="false">)</cb:mo> </cb:mrow> </cb:msubsup> </cb:math> , which modify the electroweak couplings of the top quark through contributions to the <gb:math xmlns:gb="http://www.w3.org/1998/Math/MathML" display="inline"> <gb:mi>t</gb:mi> <gb:mi>W</gb:mi> </gb:math> -scattering vertex. The interpretation acts as a case study to emphasize the importance of energy-dependent sensitivity, multiprocess, and multioperator EFT contributions.G. Aad; E. Aakvaag; B. Abbott; S. Abdelhameed; K. Abeling; N. J. Abicht; S. H. Abidi; M. Aboelela; A. Aboulhorma; H. Abramowicz; Y. Abulaiti; B. S. Acharya; A. Ackermann; C. Adam Bourdarios; L. Adamczyk; S. V. Addepalli; M. J. Addison; J. Adelman; A. Adiguzel; T. Adye; A. A. Affolder; Y. Afik; M. N. Agaras; A. Aggarwal; C. Agheorghiesei; F. Ahmadov; S. Ahuja; S. Ahuja; X. Ai; G. Aielli; A. Aikot; M. Ait Tamlihat; B. Aitbenchikh; T. P. A. Åkesson; A. V. Akimov; D. Akiyama; N. N. Akolkar; S. Aktas; G. L. Alberghi; J. Albert; U. Alberti; P. Albicocco; G. L. Albouy; S. Alderweireldt; Z. L. Alegria; M. Aleksa; I. N. Aleksandrov; C. Alexa; T. Alexopoulos; F. Alfonsi; M. Algren; M. Alhroob; B. Ali; H. M. J. Ali; S. Ali; S. W. Alibocus; M. Aliev; G. Alimonti; W. Alkakhi; C. Allaire; B. M. M. Allbrooke; D. R. Allen; J. S. Allen; J. F. Allen; P. P. Allport; A. Aloisio; F. Alonso; C. Alpigiani; Z. M. K. Alsolami; A. Alvarez Fernandez; M. Alves Cardoso; M. G. Alviggi; M. Aly; Y. Amaral Coutinho; A. Ambler; C. Amelung; M. Amerl; C. G. Ames; T. Amezza; D. Amidei; B. Amini; K. Amirie; A. Amirkhanov; S. P. Amor Dos Santos; K. R. Amos; D. Amperiadou; S. An; C. Anastopoulos; T. Andeen; J. K. Anders; A. C. Anderson; A. Andreazza; S. Angelidakis; A. Angerami; A. V. Anisenkov; A. Annovi; C. Antel; E. Antipov; M. Antonelli; F. Anulli

Electroweak interaction; Large Hadron Collider; Pair production; Muon; Top quark; Effective field theory; Boson; Atlas (anatomy); Technicolor; Quark; Physics; Particle physics; Nuclear physics; Production (economics); Standard Model (mathematical formulation); Event (particle physics); Quantum field theory; Collision; Gauge boson; Lepton; Branching fraction; Detector; Elementary particle

2026-04-06https://doi.org/10.1103/p5nz-95m3Physical review. D/Physical review. D. 20261Search for Beyond the Standard Model physics with anomaly detection in multilepton final states in pp collisions at $$\sqrt{s}=13~\textrm{TeV}$$ with the ATLAS detectorAbstract A model-agnostic search for Beyond the Standard Model physics is presented, targeting final states with at least four light leptons (electrons or muons). The search regions are separated by event topology and unsupervised machine learning is used to identify anomalous events in the full 140 fb $$^{-1}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mmultiscripts> <mml:mrow/> <mml:mrow/> <mml:mrow> <mml:mo>-</mml:mo> <mml:mn>1</mml:mn> </mml:mrow> </mml:mmultiscripts> </mml:math> of proton–proton collision data collected with the ATLAS detector during Run 2. No significant excess above the Standard Model background expectation is observed. Model-agnostic limits are presented in each topology, along with limits on several benchmark models including vector-like leptons, wino-like charginos and neutralinos, or smuons. Limits are set on the flavourful vector-like lepton model for the first time.G. Aad; E. Aakvaag; B. Abbott; S. Abdelhameed; K. Abeling; N. J. Abicht; S. H. Abidi; M. Aboelela; A. Aboulhorma; H. Abramowicz; Y. Abulaiti; B. S. Acharya; A. Ackermann; C. Adam Bourdarios; L. Adamczyk; S. V. Addepalli; M. J. Addison; J. Adelman; A. Adiguzel; T. Adye; A. A. Affolder; Y. Afik; M. N. Agaras; A. Aggarwal; C. Agheorghiesei; F. Ahmadov; S. Ahuja; S. Ahuja; X. Ai; G. Aielli; A. Aikot; M. Ait Tamlihat; B. Aitbenchikh; M. Akbiyik; T. P. A. Åkesson; A. V. Akimov; D. Akiyama; N. N. Akolkar; S. Aktas; G. L. Alberghi; J. Albert; U. Alberti; P. Albicocco; G. L. Albouy; S. Alderweireldt; Z. L. Alegria; M. Aleksa; I. N. Aleksandrov; C. Alexa; T. Alexopoulos; F. Alfonsi; M. Algren; M. Alhroob; B. Ali; H. M. J. Ali; S. Ali; S. W. Alibocus; M. Aliev; G. Alimonti; W. Alkakhi; C. Allaire; B. M. M. Allbrooke; D. R. Allen; J. S. Allen; J. F. Allen; P. P. Allport; A. Aloisio; F. Alonso; C. Alpigiani; Z. M. K. Alsolami; A. Alvarez Fernandez; M. Alves Cardoso; M. G. Alviggi; M. Aly; Y. Amaral Coutinho; A. Ambler; C. Amelung; M. Amerl; C. G. Ames; T. Amezza; D. Amidei; B. Amini; K. Amirie; A. Amirkhanov; S. P. Amor Dos Santos; K. R. Amos; D. Amperiadou; S. An; C. Anastopoulos; T. Andeen; J. K. Anders; A. C. Anderson; A. Andreazza; S. Angelidakis; A. Angerami; A. V. Anisenkov; A. Annovi; C. Antel; E. Antipov; M. Antonelli

Atlas (anatomy); Lepton; Physics beyond the Standard Model; Standard Model (mathematical formulation); Detector; Atlas detector; Anomaly detection; Physics; Particle physics; Benchmark (surveying); Event (particle physics); Large Hadron Collider; Anomaly (physics); Set (abstract data type); Data set; ATLAS experiment; Collision

2026-03-11https://doi.org/10.1140/epjc/s10052-025-15218-2The European Physical Journal C 20261Measurements of differential cross-sections of WbWb production in the dilepton channel in pp collisions at $$ \sqrt{s}=13 $$ TeV using the ATLAS detectorA bstract At the Large Hadron Collider, the WbWb final state is expected to be dominated by $$ t\overline{t} $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mi>t</mml:mi> <mml:mover> <mml:mi>t</mml:mi> <mml:mo>¯</mml:mo> </mml:mover> </mml:math> production with a contribution from single-top processes. Differential cross-sections for WbWb production in the dilepton decay channel are measured at the particle level as a function of various kinematic variables. The analysis is based on data from proton-proton collisions at a centre-of-mass energy of $$ \sqrt{s}=13 $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msqrt> <mml:mi>s</mml:mi> </mml:msqrt> <mml:mo>=</mml:mo> <mml:mn>13</mml:mn> </mml:math> TeV, recorded by the ATLAS detector at the Large Hadron Collider over the period from 2015 to 2018, corresponding to an integrated luminosity of 140 fb − 1 . Measurements are performed within the fiducial phase-space defined by the presence of two b -jets and one electron and one muon of opposite charges. The differential cross-sections are corrected for detector effects and unfolded to the particle level. Results are compared with predictions from Monte Carlo event generators at next-to-leading order in perturbative quantum chromodynamics; overall the measurements are in reasonable agreement with several generator setups, although no single prediction is able to describe all measured distributions simultaneously. These measurements provide valuable constraints on the modelling of WbWb production and the interference between doubly resonant and singly resonant WbWb production.Georges Aad; Erlend Aakvaag; B. Abbott; Sara Abdelhameed; K. Abeling; Nils Julius Abicht; S. H. Abidi; Mohammed Aboelela; A. Aboulhorma; H. Abramowicz; Y. Abulaiti; B. S. Acharya; Anke Ackermann; C. Adam Bourdarios; L. Adamczyk; Sagar Addepalli; Matthew John Addison; J. Adelman; A. Adıgüzel; T. Adye; A. A. Affolder; Y. Afik; M. N. Agaras; A. Aggarwal; C. Agheorghiesei; F. Ahmadov; S. Ahuja; X. Ai; G. Aielli; A. Aikot; M. Ait Tamlihat; B. Aitbenchikh; M. Akbiyik; T. P. A. Åkesson; A. V. Akimov; D. Akiyama; Nilima Nilesh Akolkar; S. Aktas; G. L. Alberghi; J. Albert; P. Albicocco; Guillaume Lucas Albouy; S. Alderweireldt; Z. L. Alegria; M. Aleksa; I. N. Aleksandrov; C. Alexa; T. Alexopoulos; F. Alfonsi; M. Algren; M. Alhroob; B. Ali; H. M. J. Ali; S. Ali; Samuel William Alibocus; M. Aliev; G. Alimonti; W. Alkakhi; C. Allaire; B. M. M. Allbrooke; Jonny Allen; Julia Frances Allen; P. P. Allport; A. Aloisio; F. Alonso; C. Alpigiani; Zainab Mohammad K Alsolami; A. Álvarez Fernández; Mario Alves Cardoso; M. G. Alviggi; M. Aly; Y. Amaral Coutinho; A. Ambler; C. Amelung; Christoph Amelung; C. G. Ames; Thiziri Amezza; D. Amidei; Baktash Amini; Kyle Amirie; Artem Amirkhanov; S. P. Amor Dos Santos; K. R. Amos; Dimitra Amperiadou; Shiwen An; C. Anastopoulos; T. Andeen; J. K. Anders; Adam Campbell Anderson; A. Andreazza; S. Angelidakis; A. Angerami; A. V. Anisenkov; A. Annovi; C. Antel; E. Antipov; Mario Antonelli; F. Anulli; M. Aoki; T. Aoki

Large Hadron Collider; Muon; Detector; Atlas (anatomy); Hadron; Monte Carlo method; Luminosity; Production (economics); Atlas detector; Channel (broadcasting); Physics; Nuclear physics; Particle physics; Muon collider; Collider; Differential (mechanical device); Event generator; Interference (communication); Electron; Pair production; ATLAS experiment

2026-02-13https://doi.org/10.1007/jhep02(2026)153Journal of High Energy Physics 20261Electroweak diboson production in association with a high-mass dijet system in semileptonic final states from pp collisions at $$\sqrt{s} = 13$$ TeV with the ATLAS detectorAbstract This paper reports the observation of electroweak diboson ( WW / WZ / ZZ ) production in association with a high-mass dijet system, in which final states with one boson decaying leptonically and the other boson decaying hadronically are studied. The hadronically decaying W / Z boson is reconstructed as either two small-radius jets or one large-radius jet with jet substructure requirements. The data analyzed correspond to an integrated luminosity of $$140 \ \text {fb}^{-1}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:mn>140</mml:mn> <mml:mspace/> <mml:msup> <mml:mtext>fb</mml:mtext> <mml:mrow> <mml:mo>-</mml:mo> <mml:mn>1</mml:mn> </mml:mrow> </mml:msup> </mml:mrow> </mml:math> of proton–proton collisions at a center-of-mass energy of $$\sqrt{s}=13$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:msqrt> <mml:mi>s</mml:mi> </mml:msqrt> <mml:mo>=</mml:mo> <mml:mn>13</mml:mn> </mml:mrow> </mml:math> TeV collected with the ATLAS detector during the 2015-2018 data taking at the Large Hadron Collider. The electroweak production of WW / WZ / ZZ in association with two jets is observed in a phase space dominated by vector-boson scattering with a significance of $$7.4\sigma $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:mn>7.4</mml:mn> <mml:mi>σ</mml:mi> </mml:mrow> </mml:math> (expected $$6.1\sigma $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:mn>6.1</mml:mn> <mml:mi>σ</mml:mi> </mml:mrow> </mml:math> ) and the signal strength is determined to be $$1.28^{+0.23}_{-0.21}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:mn>1</mml:mn> <mml:mo>.</mml:mo> <mml:msubsup> <mml:mn>28</mml:mn> <mml:mrow> <mml:mo>-</mml:mo> <mml:mn>0.21</mml:mn> </mml:mrow> <mml:mrow> <mml:mo>+</mml:mo> <mml:mn>0.23</mml:mn> </mml:mrow> </mml:msubsup> </mml:mrow> </mml:math> . The corresponding production cross section in a fiducial phase space is measured in addition. The signal strengths of both electroweak and QCD associated diboson productions are furthermore measured in a two-dimensional fit, the result of which agrees with the Standard Model prediction. The data are interpreted in the context of a dimension-8 effective field theory to probe anomalous quartic gauge couplings resulting in the first set of exclusion limits on the Wilson coefficients in the semileptonic channel reported by the ATLAS Collaboration. The observed limits for the S02, T0 and M0 operators are $$(-\,3.96< f_{S02} / \Lambda ^4 < 3.96)$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:mo>(</mml:mo> <mml:mo>-</mml:mo> <mml:mspace/> <mml:mn>3.96</mml:mn> <mml:mo><</mml:mo> <mml:msub> <mml:mi>f</mml:mi> <mml:mrow> <mml:mi>S</mml:mi> <mml:mn>02</mml:mn> </mml:mrow> </mml:msub> <mml:mo>/</mml:mo> <mml:msup> <mml:mi>Λ</mml:mi> <mml:mn>4</mml:mn> </mml:msup> <mml:mo><</mml:mo> <mml:mn>3.96</mml:mn> <mml:mo>)</mml:mo> </mml:mrow> </mml:math> TeV $$^{-4}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mmultiscripts> <mml:mrow/> <mml:mrow/> <mml:mrow> <mml:mo>-</mml:mo> <mml:mn>4</mml:mn> </mml:mrow> </mml:mmultiscripts> </mml:math> , $$(-\,0.25< f_{T0} / \Lambda ^4 < 0.22)$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:mo>(</mml:mo> <mml:mo>-</mml:mo> <mml:mspace/> <mml:mn>0.25</mml:mn> <mml:mo><</mml:mo> <mml:msub> <mml:mi>f</mml:mi> <mml:mrow> <mml:mi>T</mml:mi> <mml:mn>0</mml:mn> </mml:mrow> </mml:msub> <mml:mo>/</mml:mo> <mml:msup> <mml:mi>Λ</mml:mi> <mml:mn>4</mml:mn> </mml:msup> <mml:mo><</mml:mo> <mml:mn>0.22</mml:mn> <mml:mo>)</mml:mo> </mml:mrow> </mml:math> TeV $$^{-4}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mmultiscripts> <mml:mrow/> <mml:mrow/> <mml:mrow> <mml:mo>-</mml:mo> <mml:mn>4</mml:mn> </mml:mrow> </mml:mmultiscripts> </mml:math>Georges Aad; Erlend Aakvaag; B. Abbott; Sara Abdelhameed; K. Abeling; Nils Julius Abicht; S. H. Abidi; Mohammed Aboelela; A. Aboulhorma; H. Abramowicz; Yiming Abulaiti; B. S. Acharya; Anke Ackermann; C. Adam Bourdarios; L. Adamczyk; S. V. Addepalli; Matt Addison; J. Adelman; Aytul Adiguzel; T. Adye; A. A. Affolder; Y. Afik; M. N. Agaras; Anamika Aggarwal; C. Agheorghiesei; F. Ahmadov; S. Ahuja; X. Ai; G. Aielli; A. Aikot; M. Ait Tamlihat; B. Aitbenchikh; M. Akbiyik; T. P. A. Åkesson; A. V. Akimov; D. Akiyama; Nilima Nilesh Akolkar; S. Aktas; G. L. Alberghi; J. Albert; Pietro Albicocco; Guillaume Lucas Albouy; S. Alderweireldt; Z. L. Alegria; Martin Aleksa; I. N. Aleksandrov; C. Alexa; T. Alexopoulos; Fabrizio Alfonsi; M. Algren; M. Alhroob; B. Ali; Hanadi Ali; S. Ali; Samuel William Alibocus; M. Aliev; G. Alimonti; W. Alkakhi; C. Allaire; Benedict Allbrooke; Jonny Allen; Julia Frances Allen; P. P. Allport; A. Aloisio; F. Alonso; C. Alpigiani; Zainab Mohammad K Alsolami; A. Álvarez Fernández; Mario Alves Cardoso; M. G. Alviggi; M. Aly; Y. Amaral Coutinho; A. Ambler; Christoph Amelung; M. Amerl; Christoph Ames; Thiziri Amezza; D. Amidei; Baktash Amini; Kyle Amirie; Artem Amirkhanov; S. P. Amor Dos Santos; K. R. Amos; Dimitra Amperiadou; Shiwen An; C. Anastopoulos; T. Andeen; J. K. Anders; Adam Campbell Anderson; Attilio Andreazza; S. Angelidakis; A. Angerami; A. V. Anisenkov; A. Annovi; C. Antel; E. Antipov; M. Antonelli; Fabio Anulli; M. Aoki; T. Aoki

Electroweak interaction; Atlas (anatomy); Large Hadron Collider; Vector boson; Tevatron; Gauge boson; Quantum chromodynamics; Boson; Higgs boson; Physics; Particle physics; Nuclear physics; Standard Model (mathematical formulation); Context (archaeology); Phase space; Hadron; Jet (fluid); Production (economics); ATLAS experiment; Atlas detector; Detector

2026-04-30https://doi.org/10.1140/epjc/s10052-025-15217-3The European Physical Journal C 20261β-Cyclodextrin supramolecular complexes of Plinia peruviana leaves extract: advanced physicochemical characterization and enhanced anti-inflammatory and wound-healing activityPriscila de Lima Paula; Francisco J. R. Mejías; Alexandra G. Durán; Ari S.O. Lemos; Elaine Soares Coimbra; Maria Clara Machado Resende Guedes; Gilson Costa Macedo; Lara Melo Campos; Luiz Fernando Cappa de Oliveira; Ângelo M. L. Denadai; Francisco A. Macı́as; Rodrigo Luiz Fabri

Cytotoxicity; Supramolecular chemistry; Nitric oxide; Biocompatible material; Biological activity; Curcumin; Structure–activity relationship; Chemistry; Biochemistry; Combinatorial chemistry; Ellagic acid; Antioxidant; Cosmeceutical; MTT assay; Natural product; Stereochemistry

2026-05-01https://doi.org/10.1016/j.jddst.2026.108403Journal of Drug Delivery Science and Technology 20261High prevalence of G6PD mutations in blood donors from the Brazilian Amazon region.BACKGROUND: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a genetic condition caused primarily by single nucleotide polymorphisms (SNPs). It is the most prevalent enzymopathy globally and directly impacts the ability of red blood cells to respond to oxidative stress. This study aimed to determine the prevalence of G6PD variants in Amazon blood donors. MATERIALS AND METHODS: A cross-sectional study was conducted at the Foundation of Hemotherapy and Hematology of Amazonas (HEMOAM) between January and June of 2024. The study analyzed 5,000 donor samples using the quantitative polymerase chain reaction (qPCR) to detect G6PD genetic variants. RESULTS: G6PD variants were present in 364 (7.28%) donors, with the most common being c.376A>G (3.82%), c.292G>A (1.92%), and simultaneous c.292G>A/376A>G (0.90%). Other rare variants were also identified, including c.653C>T, c.1093G>A, c.968T>C; c.632A>T; c.1429G>A; c.700G>T; c.1192G>A and c.197T>A/c.202G>A, representing 0.64% of the total. Most donors exhibiting mutations were male (71.7%), with a mean age of 34.1±11.9 years for males and 34.0±10.5 years for females. The most prevalent blood group in both sexes was O+, with a frequency of 59.7% in males and 61.9% in females. DISCUSSION: This study constitutes the most extensive molecular testing for G6PD mutations in the state of Amazonas, offering a comprehensive overview of G6PD deficiency (G6PDd) in the region. The estimated prevalence rate of G6PD mutations among Manaus blood donors was 7.28%, which is consistent with other findings in Brazil. In conclusion, G6PDd has the potential to compromise red blood cell quality during storage and their survival post-transfusion. This study enhanced the methods used to identify mutations impacting blood storage, with the aim of improving transfusion safety and efficacy.Juliana Nascimento Vitoriano da Silva; Marcela Maria de Souza; Ana Caroline Santos Castro; Lorena Alves Santos; Marcelo Reis do Nascimento; Érico Jorge Silva Freitas; Iarla Priscila Castro Tavares; Monique Moraes Pinto Luciano; Monik Oney Oliveira do Nascimento; Fernando Lopes Oliveira Gomes; Jessica Shellcy Vital Campelo; Rajendranath Ramasawmy; Nelson Abrahim Fraiji; Sérgio Roberto Lopes Albuquerque; José Pereira de Moura Neto

Amazon rainforest; Blood transfusion; Blood donations; Glucosephosphate Dehydrogenase Deficiency; Mutation; Red blood cell; Medicine; Immunology; Biology

2026-01-31https://pubmed.ncbi.nlm.nih.gov/41183279PubMed 20261Measurement of the Higgs boson production in association with top quarks in multilepton final states in pp collisions at $$ \sqrt{s}=13 $$ TeV with the ATLAS detectorA bstract A measurement of the associated production of a top-quark pair with the Higgs boson ( $$ t\overline{t}H $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mi>t</mml:mi> <mml:mover> <mml:mi>t</mml:mi> <mml:mo>¯</mml:mo> </mml:mover> <mml:mi>H</mml:mi> </mml:math> ) in multilepton final states is presented. The analysis is based on a data sample of proton-proton collisions at $$ \sqrt{s}=13 $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msqrt> <mml:mi>s</mml:mi> </mml:msqrt> <mml:mo>=</mml:mo> <mml:mn>13</mml:mn> </mml:math> TeV recorded with the ATLAS detector at the CERN Large Hadron Collider and corresponding to an integrated luminosity of 140 fb − 1 . Six final states defined by the number and flavour of reconstructed charged leptons are combined in a simultaneous likelihood fit to extract the $$ t\overline{t}H $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mi>t</mml:mi> <mml:mover> <mml:mi>t</mml:mi> <mml:mo>¯</mml:mo> </mml:mover> <mml:mi>H</mml:mi> </mml:math> signal and constrain the most relevant backgrounds. The measured $$ t\overline{t}H $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mi>t</mml:mi> <mml:mover> <mml:mi>t</mml:mi> <mml:mo>¯</mml:mo> </mml:mover> <mml:mi>H</mml:mi> </mml:math> cross-section normalised to Standard Model (SM) prediction is $$ {\sigma}_{t\overline{t}H}/{\sigma}^{\mathrm{SM}}=0.{63}_{-0.19}^{+0.20} $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msub> <mml:mi>σ</mml:mi> <mml:mrow> <mml:mi>t</mml:mi> <mml:mover> <mml:mi>t</mml:mi> <mml:mo>¯</mml:mo> </mml:mover> <mml:mi>H</mml:mi> </mml:mrow> </mml:msub> <mml:mo>/</mml:mo> <mml:msup> <mml:mi>σ</mml:mi> <mml:mi>SM</mml:mi> </mml:msup> <mml:mo>=</mml:mo> <mml:mn>0</mml:mn> <mml:mo>.</mml:mo> <mml:msubsup> <mml:mn>63</mml:mn> <mml:mrow> <mml:mo>−</mml:mo> <mml:mn>0.19</mml:mn> </mml:mrow> <mml:mrow> <mml:mo>+</mml:mo> <mml:mn>0.20</mml:mn> </mml:mrow> </mml:msubsup> </mml:math> . This result corresponds to an observed (expected) significance of 3.3 σ (5.3 σ ). Additionally, two other fits are used to measure the $$ t\overline{t}H $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mi>t</mml:mi> <mml:mover> <mml:mi>t</mml:mi> <mml:mo>¯</mml:mo> </mml:mover> <mml:mi>H</mml:mi> </mml:math> cross-section differentially in bins of the Higgs boson transverse momentum in the simplified template cross-section framework, and to extract the associated production cross-section of a single top-quark with the Higgs boson ( tH ) together with the $$ t\overline{t}H $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mi>t</mml:mi> <mml:mover> <mml:mi>t</mml:mi> <mml:mo>¯</mml:mo> </mml:mover> <mml:mi>H</mml:mi> </mml:math> one. The CP structure of the top quark-Higgs boson Yukawa coupling is probed through an analysis of $$ t\overline{t}H $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mi>t</mml:mi> <mml:mover> <mml:mi>t</mml:mi> <mml:mo>¯</mml:mo> </mml:mover> <mml:mi>H</mml:mi> </mml:math> and tH events. The results are compatible with the SM hypothesis, and values of the mixing angle between CP -even and CP -odd top-Higgs Yukawa couplings of | α | > 62 ° are excluded at 68% confidence level.G. Aad; Erlend Aakvaag; B. Abbott; Sara Abdelhameed; K. Abeling; Nils Julius Abicht; S. H. Abidi; Mohammed Aboelela; A. Aboulhorma; H. Abramowicz; B. S. Acharya; Anke Ackermann; C. Adam Bourdarios; L. Adamczyk; S. V. Addepalli; Matthew John Addison; J. Adelman; Aytul Adiguzel; T. Adye; A. A. Affolder; Yoav Afik; M. N. Agaras; A. Aggarwal; C. Agheorghiesei; F. Ahmadov; S. Ahuja; S. Ahuja; X. Ai; G. Aielli; A. Aikot; M. Ait Tamlihat; B. Aitbenchikh; T. P. A. Åkesson; D. Akiyama; Nilima Nilesh Akolkar; S. Aktas; G. L. Alberghi; J. Albert; Una Helena Alberti; Pietro Albicocco; Guillaume Lucas Albouy; S. Alderweireldt; Z. L. Alegria; Martin Aleksa; C. Alexa; I. N. Aleksandrov; T. Alexopoulos; Fabrizio Alfonsi; Malte Algren; M. Alhroob; B. Ali; Hanadi Ali; S. Ali; Samuel William Alibocus; M. Aliev; G. Alimonti; W. Alkakhi; C. Allaire; Benedict Allbrooke; Derrick Allen; Jonny Allen; Julia Frances Allen; A. Aloisio; F. Alonso; C. Alpigiani; Zainab Mohammad K Alsolami; A. Álvarez Fernández; Mario Alves Cardoso; Mariagrazia Alviggi; M. Aly; A. Ambler; Christoph Amelung; Christoph Amelung; C. G. Ames; Thiziri Amezza; Baktash Amini; Kyle Amirie; Artem Amirkhanov; S. P. Amor Dos Santos; Dimitra Amperiadou; Shiwen An; Christos Anastopoulos; T. Andeen; J. K. Anders; Adam Campbell Anderson; Attilio Andreazza; S. Angelidakis; A. Angerami; A. V. Anisenkov; A. Annovi; C. Antel; E. Antipov; Mario Antonelli; Fabio Anulli; Masato Aoki; T. Aoki; M. A. Aparo; L. Aperio Bella; M. Apicella; C. Appelt

Large Hadron Collider; Higgs boson; Yukawa potential; Lepton; Boson; Top quark; Standard Model (mathematical formulation); ATLAS experiment; Atlas (anatomy); Physics; Particle physics; Nuclear physics; Pair production; Quark; Luminosity; Hadron; Detector; Coupling (piping); Production (economics); Elementary particle

2026-05-15https://doi.org/10.1007/jhep05(2026)183Journal of High Energy Physics 20261Development, characterization, and evaluation of chitosan gel with tea tree oil for odontogenic infectionsThis study developed and evaluated the stability of a chitosan (Ch) and tea tree oil (TTO) gel formulation to prevent dental biofilm formation and the development of odontogenic infections. Three gels were developed: a control hydroxyethylcellulose gel containing sunflower seed oil (CG), a chitosan gel containing sunflower seed oil (ChG), and a chitosan gel containing tea tree oil (Ch+TTOG). Organoleptic and physicochemical characterizations, as well as evaluation of the antimicrobial activity and cytotoxicity of the three gels, were performed. The gels remained stable in appearance, color, odor, and taste under all storage conditions evaluated. The pH of the gels (ChG and Ch+TTOG) ranged from 5.54 to 6.11 over time. The viscosity of the three gels showed pseudoplastic and thixotropic behavior. Raman spectroscopy confirmed the molecular stability of the gels. The ChG and Ch+TTOG gels showed inhibitory activity against Aggregatibacter actinomycetemcomitans, Streptococcus sanguinis, Streptococcus sobrinus, and Candida albicans. The Ch+TTOG gel stood out for maintaining inhibitory action at lower concentrations for up to three months, especially when stored at 4°C. The gels showed no cytotoxicity to the tested cells, with viability exceeding 70%. The Ch+TTOG gel demonstrated organoleptic and physicochemical stability under different storage conditions, antimicrobial activity, and absence of cytotoxicity, suggesting its potential to prevent dental biofilm formation and the development of caries and periodontal diseases.Fernanda Ramos de Faria; Mariana Simões de Oliveira; Michel de Oliveira Sales Júnior; Amanda Marota de Oliveira; Daphne Fonseca de Coppoli Lanferini; Antonio Carlos Sant apos Ana; Raphael Fortes Marcomini; Luiz Fernando Grespan Setz; Ana Carolina Morais Apolônio; Márcio José da Silva Campos

Chitosan; Organoleptic; Antimicrobial; Sunflower oil; Thixotropy; Polysaccharide; Aggregatibacter actinomycetemcomitans; Biofilm; Demineralization; Chemistry; Food science; Microbiology; Chromatography; Chitin; Essential oil; Streptococcus mitis; Eucalyptus oil; Bacteria; Preservative; Tea tree oil; Cytotoxicity

2026-04-15https://doi.org/10.1016/j.microb.2026.100720The Microbe 20261Search for signatures of electroweakinos with photons, jets, and large missing transverse momentum in $$ \sqrt{s}=13 $$ TeV pp collisions with the ATLAS detectorA bstract A search for final states characterised by at least one isolated high transverse-momentum photon, jets and large missing transverse momentum is presented. Such a final state might occur in gauge-mediated supersymmetric models where a pair of binos and higgsinos mix to form neutralinos, one of which decays into a photon plus a gravitino while the other decays into a Higgs boson, a Z boson or a photon, plus a gravitino. The search is performed using the full Run-2 data sample of 140 fb − 1 of $$ \sqrt{s}=13 $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msqrt> <mml:mi>s</mml:mi> </mml:msqrt> <mml:mo>=</mml:mo> <mml:mn>13</mml:mn> </mml:math> TeV proton-proton collisions collected by the ATLAS detector at the Large Hadron Collider. No significant excess of events is observed above the Standard Model prediction and model-dependent exclusion limits at the 95% confidence level are set. These limits are interpreted in terms of the masses of gauginos, which are excluded up to 1.2 TeV depending on their branching ratios, and on their branching ratios as a function of their mass.G. Aad; Erlend Aakvaag; B. Abbott; Sara Abdelhameed; Kira Abeling; Nils Julius Abicht; S. H. Abidi; Mohammed Aboelela; A. Aboulhorma; H. Abramowicz; Y. Abulaiti; B. S. Acharya; Anke Ackermann; C. Adam Bourdarios; L. Adamczyk; Sagar Addepalli; Matthew John Addison; J. Adelman; Aytul Adiguzel; T. Adye; A. A. Affolder; Yoav Afik; M. N. Agaras; A. Aggarwal; C. Agheorghiesei; F. Ahmadov; S. Ahuja; X. Ai; G. Aielli; A. Aikot; M. Ait Tamlihat; B. Aitbenchikh; M. Akbiyik; T. P. A. Åkesson; A. V. Akimov; Daiya Akiyama; Nilima Nilesh Akolkar; S. Aktas; G. L. Alberghi; J. Albert; Una Helena Alberti; P. Albicocco; Guillaume Lucas Albouy; S. Alderweireldt; Z. L. Alegria; Martin Aleksa; C. Alexa; I. N. Aleksandrov; Theodoros Alexopoulos; Fabrizio Alfonsi; Malte Algren; M. Alhroob; B. Ali; Hanadi Ali; S. Ali; Samuel William Alibocus; Malik Aliev; G. Alimonti; W. Alkakhi; C. Allaire; Benedict Allbrooke; Jonny Allen; Julia Frances Allen; P. P. Allport; A. Aloisio; F. Alonso; C. Alpigiani; Zainab Mohammad K Alsolami; A. Álvarez Fernández; Mario Alves Cardoso; M. G. Alviggi; M. Aly; A. Ambler; Christoph Amelung; Christoph Amelung; C. G. Ames; Thiziri Amezza; D. Amidei; Baktash Amini; Kyle Amirie; Artem Amirkhanov; S. P. Amor Dos Santos; K. R. Amos; Dimitra Amperiadou; Shiwen An; C. Anastopoulos; T. Andeen; J. K. Anders; Adam Campbell Anderson; A. Andreazza; S. Angelidakis; A. Angerami; A. V. Anisenkov; A. Annovi; C. Antel; E. Antipov; M. Antonelli; Fabio Anulli; Masato Aoki; T. Aoki

Large Hadron Collider; Higgs boson; Atlas (anatomy); Atlas detector; Gravitino; Branching fraction; Hadron; Detector; Boson; Physics; Particle physics; Nuclear physics; ATLAS experiment; Standard Model (mathematical formulation); Supersymmetry; Transverse plane; Limit (mathematics); CMB cold spot; Branching (polymer chemistry)

2026-04-17https://doi.org/10.1007/jhep04(2026)150Journal of High Energy Physics 20261Measurement of the top-quark mass using decays with a J/ψ meson at $$ \sqrt{s}=13 $$ TeV with the ATLAS detectorA bstract The top-quark mass is measured using top-quark decays producing an isolated lepton and J / ψ meson reconstructed in its μ + μ − decay mode. The data sample was recorded with the ATLAS detector in proton-proton collisions at a centre-of-mass energy of $$ \sqrt{s}=13 $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msqrt> <mml:mi>s</mml:mi> </mml:msqrt> <mml:mo>=</mml:mo> <mml:mn>13</mml:mn> </mml:math> TeV during Run 2 of the Large Hadron Collider, corresponding to an integrated luminosity of 140 fb − 1 . The measurement is based on the invariant mass m ( ℓμ + μ − ) of the system made of the isolated lepton ℓ from the W boson decay and the non-isolated μ + μ − pair from a J / ψ decay of a b -hadron, exploiting its sensitivity to the top-quark mass. An unbinned maximum-likelihood fit to the m ( ℓμ + μ − ) distribution is performed to extract the top-quark mass. The top-quark mass is measured to be m top = 172.17 ± 0.80 (stat) ± 0.81 (syst) ± 1.07 (recoil) GeV, with a total uncertainty of 1.56 GeV. The third uncertainty arises from changing the dipole parton shower gluon-recoil scheme used in top-quark decays.G. Aad; Erlend Aakvaag; Braden Keim Abbott; Sara Abdelhameed; Kira Abeling; Nils Julius Abicht; S. H. Abidi; Mohammed Aboelela; A. Aboulhorma; Halina Abramowicz; Yiming Abulaiti; B. S. Acharya; Anke Ackermann; C. Adam Bourdarios; L. Adamczyk; Sagar Addepalli; Matthew John Addison; J. Adelman; Aytul Adiguzel; T. Adye; A. A. Affolder; Y. Afik; M. N. Agaras; A. Aggarwal; C. Agheorghiesei; F. Ahmadov; S. Ahuja; S. Ahuja; X. Ai; G. Aielli; A. Aikot; M. Ait Tamlihat; B. Aitbenchikh; M. Akbiyik; T. P. A. Åkesson; Andrei Akimov; Daiya Akiyama; Nilima Nilesh Akolkar; S. Aktas; G. L. Alberghi; J. Albert; Una Helena Alberti; Pietro Albicocco; Guillaume Lucas Albouy; S. Alderweireldt; Z. L. Alegria; Martin Aleksa; C. Alexa; I. N. Aleksandrov; Theodoros Alexopoulos; F. Alfonsi; Malte Algren; M. Alhroob; B. Ali; Hanadi Ali; S. Ali; Samuel William Alibocus; Malik Aliev; G. Alimonti; W. Alkakhi; C. Allaire; Benedict Allbrooke; Derrick Allen; Jonny Allen; Julia Frances Allen; P. P. Allport; A. Aloisio; F. Alonso; C. Alpigiani; Zainab Mohammad K Alsolami; A. Alvarez Fernandez; M. Alves Cardoso; M. G. Alviggi; M. Aly; A. Ambler; Christoph Amelung; M. Amerl; C. G. Ames; Thiziri Amezza; D. Amidei; Baktash Amini; Kyle Amirie; Artem Amirkhanov; S. P. Amor Dos Santos; K. R. Amos; Dimitra Amperiadou; Shiwen An; C. Anastopoulos; T. Andeen; J. K. Anders; Adam Campbell Anderson; Attilio Andreazza; Stylianos Angelidakis; A. Angerami; A. V. Anisenkov; A. Annovi; Claire Antel; E. Antipov; M. Antonelli; Fabio Anulli

Lepton; Atlas (anatomy); Invariant mass; Parton shower; Luminosity; Large Hadron Collider; Detector; Atlas detector; Meson; Physics; Particle physics; Nuclear physics; Hadron; ATLAS experiment; Boson; Particle decay; Parton; Dipole; Standard Model (mathematical formulation); D meson; Lepton number; Mass distribution

2026-04-14https://doi.org/10.1007/jhep04(2026)099Journal of High Energy Physics 20261Search for higgsinos in compressed mass spectra using low-momentum tracks in pp collisions at $$ \sqrt{s}=13 $$ TeV with the ATLAS detectorA bstract This paper presents two searches for the electroweak production of higgsinos with compressed mass spectra using 140 fb − 1 of $$ \sqrt{s}=13 $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msqrt> <mml:mi>s</mml:mi> </mml:msqrt> <mml:mo>=</mml:mo> <mml:mn>13</mml:mn> </mml:math> TeV proton-proton collision data collected by the ATLAS experiment at the Large Hadron Collider. Events are required to feature an energetic jet, large missing transverse momentum, and at least one low-momentum charged particle that serves as a candidate higgsino decay product. In the first search, targeting higgsino mass splittings in the range of 0.3–1 GeV, the higgsinos are expected to predominantly decay into pions that are identified as low-momentum charged particles with large transverse impact parameters due to the long higgsino lifetime ( cτ ≈ 𝒪(0 . 1–10 mm)), and neural networks are used to discriminate between signal and background processes. The second search targets larger mass splittings in the range of 1–3 GeV, where the higgsinos are expected to decay promptly into low-momentum leptons, one of which is identified by dedicated low-momentum electron or muon taggers based on neural networks utilising tracking and calorimeter information. No significant excess above the Standard Model prediction is observed in either search and the results are interpreted within simplified models, to set lower limits on the masses of the higgsino-like charginos and neutralinos. Together, these searches exclude chargino masses below 126 GeV at 95% confidence level for mass splittings between the chargino and lightest neutralino in the range of 0.3–2 GeV. This represents the first ATLAS constraints in a portion of this parameter space and surpasses the limits previously set by other experiments.G. Aad; Erlend Aakvaag; B. Abbott; Sara Abdelhameed; Kira Abeling; Nils Julius Abicht; S. H. Abidi; Mohammed Aboelela; A. Aboulhorma; H. Abramowicz; Y. Abulaiti; B. S. Acharya; Anke Ackermann; C. Adam Bourdarios; L. Adamczyk; S. V. Addepalli; Matthew John Addison; J. Adelman; A. Adıgüzel; T. Adye; A. A. Affolder; Y. Afik; M. N. Agaras; A. Aggarwal; C. Agheorghiesei; F. Ahmadov; S. Ahuja; X. Ai; G. Aielli; A. Aikot; M. Ait Tamlihat; B. Aitbenchikh; M. Akbiyik; T. P. A. Åkesson; A. V. Akimov; Daiya Akiyama; Nilima Nilesh Akolkar; S. Aktas; G. L. Alberghi; J. Albert; Una Helena Alberti; Pietro Albicocco; Guillaume Lucas Albouy; S. Alderweireldt; Z. L. Alegria; Martin Aleksa; I. N. Aleksandrov; C. Alexa; T. Alexopoulos; Fabrizio Alfonsi; M. Algren; M. Alhroob; B. Ali; Hanadi Ali; S. Ali; Samuel William Alibocus; Malik Aliev; G. Alimonti; W. Alkakhi; C. Allaire; Benedict Allbrooke; Jonny Allen; Julia Frances Allen; P. P. Allport; A. Aloisio; F. Alonso; C. Alpigiani; Zainab Mohammad K Alsolami; A. Álvarez Fernández; Mario Alves Cardoso; M. G. Alviggi; M. Aly; Y. Amaral Coutinho; A. Ambler; Christoph Amelung; Christoph Amelung; Christoph Ames; Thiziri Amezza; D. Amidei; Baktash Amini; Kyle Amirie; Artem Amirkhanov; S. P. Amor Dos Santos; K. R. Amos; Dimitra Amperiadou; Shiwen An; Christos Anastopoulos; T. Andeen; J. K. Anders; Adam Campbell Anderson; A. Andreazza; S. Angelidakis; A. Angerami; A. V. Anisenkov; A. Annovi; C. Antel; E. Antipov; M. Antonelli; F. Anulli; M. Aoki

Chargino; Higgsino; Neutralino; Large Hadron Collider; Atlas (anatomy); Muon; Electroweak interaction; ATLAS experiment; Pion; Physics; Particle physics; Nuclear physics; Gluino; Range (aeronautics); Superpartner; Transverse mass; Hadron; Randall–Sundrum model; Pair production; Mass spectrum; Supersymmetry

2026-06-08https://doi.org/10.1007/jhep06(2026)094Journal of High Energy Physics 20261The Riemann problem for three-phase foam flow in porous mediaAbstract Gas injection in the context of the three-phase flow in porous media appears in applications such as Enhanced Oil Recovery, aquifer remediation, and carbon capture, utilization, and storage (CCUS). In general, this technique suffers from a difficulty related to excessive gas mobility, which can be circumvented by using foam. This study addresses the non-linear system of differential equations describing the three-phase foam flow based on Corey relative permeability functions. A major obstacle is an umbilic point, where the characteristic wave velocities for different families coincide, complicating the identification of stable wave structures. We developed a methodology to solve the Riemann problem describing the three-phase foam displacement in the case when the gas viscosity exceeds that of oil and water. To allow the analysis, we assume foam in local equilibrium (or maximum foam texture), resulting in a constant mobility reduction factor (MRF). These simplifications allowed the classification of possible solutions for the injection of foamed gas and water mixtures under a wide range of initial conditions within the framework of non-classical Conservation Law Theory. As a relevant industrial application of the proposed solution, we investigate the conditions resulting in oil bank formation. Besides improving the general physical understanding of foam flow in a porous medium, this analysis can be applied to calibrate numerical simulators and perform uncertainty quantification. Our analytical estimates were validated through numerical simulations.Luis Lozano; Grigori Chapiro; D. Marchesin

Porous medium; Context (archaeology); Viscosity; Flow (mathematics); Permeability (electromagnetism); Viscous fingering; Displacement (psychology); Enhanced oil recovery; Porosity; Mechanics; Petroleum engineering; Relative permeability; Darcy's law; Numerical analysis; Mathematics; Riemann problem; Partial differential equation; Geotechnical engineering; Aquifer; Capillary action; Fluid dynamics

2026-05-12https://doi.org/10.1007/s10596-026-10424-7Computational Geosciences 20261pedrolugao/FittingAedes: Predictions of Aedes Dynamical Population - v2Second version of publishable code for the paper Spatial and temporal prediction of Aedes aegypti population with atmospheric and urban forms dependence. Accurately predicting mosquito population dynamics in cities requires models that couple climatic sensitivity with urban spatial heterogeneity. We developed a spatially explicit, climate-driven framework that integrates satellite imagery, field observations, and biology to simulate \textit{Aedes aegypti} dynamics across heterogeneous urban landscapes. A novel decomposition technique was introduced to disentangle entomological observations from mixed urban sites into landscape-specific time series for houses, streets, and parks. We provide a robust parameter estimation through a constrained inverse problem, revealing distinct temperature responses and biological processes across environments. Model validation against both egg and adult mosquito data from five Brazilian cities yielded strong correlations with the majority falling between $\rho$ = 0.4 and 0.8, confirming the model ability to reproduce observed spatiotemporal patterns. This integration of climate dependence, landscape quantification, and empirical validation provides a potential tool for anticipating mosquito abundance across space and time. By identifying periods and locations of elevated risk, the framework supports targeted, cost-effective interventions against dengue and other vector-borne diseases in a rapidly urbanizing and warming world.Lugão, Pedro; Silva, Monalisa; Cascelli, Raphael; Chapiro, Grigori

Population; Temporal scales; Spatial ecology; Climate change; Aedes aegypti; Abundance (ecology); Field (mathematics); Aedes; Geography; Ecology; Environmental science; Climate model; Climatology; Estimation; Population model; Meteorology; Econometrics

2026-02-25https://doi.org/10.5281/zenodo.17681328Zenodo (CERN European Organization for Nuclear Research) 20261Electricity Demand Forecasting Using Federated and Centralized Learning: Assessment of Key ComponentsPaulo Vitor B. Ramos; Walquiria Silva; Bruno Leonardo N. Dias; Saulo Moraes Villela; Hugo Morais; Lucas I Pereira

Leverage (statistics); Demand forecasting; Demand response; Electricity; Key (lock); Electricity demand; Smart grid; Feature selection; Range (aeronautics); Computer science; Artificial intelligence; Machine learning; Regression analysis; Convolutional neural network; Deep learning; Operations research; Demand patterns; Regression; Energy demand

2026-01-01https://doi.org/10.2139/ssrn.6000258SSRN Electronic Journal 20261Entre a censura e a autonomia: desafios educacionais frente aos movimentos reacionáriosO objetivo deste artigo é discutir a partir de três casos de docentes que sofreram punições por abordar determinadas temáticas em salas de aula, como ondas negacionistas e conservadoras agem no cerceamento da prática docente. Nesse sentido, selecionamos três reportagens, de ocorrência brasileira, que mostram como conteúdos de biologia podem trazer questões para o trabalho docente, principalmente no que diz respeito ao controle do trabalho em sala de aula. Analisamos o impacto de duas ondas que ameaçam a docência e o ensino de biologia, que são os negacionistas e conservadores, em especial no que se articulam com movimentos de cerceamento, como o Movimento Escola Sem Partido. Compreender como tais grupos agem e suas formas de tentar silenciar determinadas temáticas e conteúdos, se mostra nevrálgico em um contexto em que a ciência é colocada à prova constantemente. Assim, evidenciamos tais articulações e argumentamos a favor de um trabalho coletivo e plural no qual possa desenvolver táticas de resistência que valorizem professores e professoras bem como possibilita um ensino de biologia contextualizado e que possibilite enfrentar os negacionismos.Bruno Felipe Venancio; Jéssica Gomes das Mercês; Sandra Escovedo Selles

Plural; Context (archaeology); Politics; Work (physics); Humanities; Sociology; Philosophy

2026-01-01https://doi.org/10.17227/bio-grafia.vol.19.num36-23363Bio-grafía 20261Front Cover: Tetra‐Cationic Pyridyl‐Porphyrins With Peripheral Rhenium(I) Complexes: Photophysics, Photobiological, and BSA‐Binding Properties (Eur. J. Inorg. Chem. 1/2026)The Front Cover highlights the synthesis, characterization and photophysics of tetra-cationic porphyrins containing peripheral tricarbonyl-ReI complexes in interaction with bio-macromolecules such as bovine serum albumin (BSA). More information can be found in the Research Article by B. A. Iglesias and co-workers (DOI: 10.1002/ejic.202500530).Rafaela C. Copello; André S. Polo; Rafael de Q. Garcia; Leonardo De Boni; Luiz Antônio S. Costa; Henrique F.V. Victória; Klaus Krambrock; Otávio Augusto Chaves; Bernardo A. Iglesias

Front cover; Bovine serum albumin; Peripheral; Characterization (materials science); Front (military); Chemistry; Cover (algebra); Polymer chemistry; Nanotechnology; Biophysics

2026-01-01https://doi.org/10.1002/ejic.70139European Journal of Inorganic Chemistry 20261Second Virial Coefficients for N 2 ···H 2 and NH···NHHigh Resolution Image Download MS PowerPoint Slide Thermodynamic properties of real gases can be accurately described using realistic intermolecular potential energy surfaces. In this work, a first-order correction to the ideal gas equation of state is introduced through the computation of the classical second virial coefficient, B ( T ), derived from the configurational partition function, which explicitly depends on the intermolecular interaction potential. As a case study, the double many-body expansion (DMBE) potential energy surface for the ground electronic state of the N 2 H 2 system was employed to derive pairwise interaction potentials for H 2 ···N 2 and NH···NH. These potentials were used to numerically evaluate the canonical partition function. Second virial coefficients, compressibility factors, and constant-volume heat capacities were computed in the temperature range 30–2000 K. The calculated B ( T ) values for H 2 ···N 2 are in good agreement with previous literature data, while the results for NH···NH lie within expected trends observed for similar systems.Marcos D. S. Alves; Maikel Y. Ballester

Virial coefficient; Virial expansion; Compressibility; Intermolecular force; Computation; Ideal gas; Virial theorem; Ground state; Real gas; Thermodynamics; Statistical physics; Intermolecular interaction; Compressibility factor; Physics; Equation of state; Chemistry; Range (aeronautics); Internal energy; Canonical ensemble; Specific heat; Partition (number theory); Pairwise comparison; Interaction energy; Potential energy

2026-01-02https://doi.org/10.1021/acs.jpca.5c04624The Journal of Physical Chemistry A 20261Brazil's health tax at a crossroads: safeguarding the constitutional victory against ultra-processed foodsBrazil faces a watershed moment for its public health policy. In 2023, the country achieved a constitutional milestone by instituting a Selective Tax to discourage the consumption of products detrimental to health and the environment.1 As Latin America's largest nation, with over 212 million inhabitants, Brazil's health policies exert considerable influence both regionally and globally. Yet this historic advance faces a constant risk of erosion from legislative manoeuvres driven by corporate interests, a conflict that epitomises the global tension between evidence-informed policymaking and the aggressive commercial determinants of health.Felipe Silva Neves; Larissa Loures Mendes; Eduardo Augusto Fernandes Nilson; Inês Rugani Ribeiro de Castro; Rafael Moreira Claro; Daniela Silva Canella; Ísis Eloah Machado; Ariene Silva do Carmo; Mariana Carvalho de Menezes; Deborah Carvalho Malta

Safeguarding; Victory; Legislation; Government (linguistics); Public health; Political science; Law; Business; Public administration

2026-01-02https://doi.org/10.1016/j.lana.2025.101363The Lancet Regional Health - Americas 20261Reply to “Enhancing methodological rigor in mechanical insufflation-exsufflation weaning studies: Commentary on patient selection, long-term outcomes, and psychological assessment”Cristiane Bastos Netto; Maycon Moura Reboredo; Erich Vidal Carvalho; Bruno Valle Pinheiro

Weaning; MEDLINE; Rigour; Ventilator weaning; Medicine; Psychiatry; Psychotherapist; Intensive care medicine

2026-01-01https://doi.org/10.1016/j.medin.2025.502302Medicina Intensiva 20261Automated Machine Learning for the Prediction of Compression Index of SoilsJonathan do Amaral Braz; Camila Martins Saporetti; Leonardo Goliatt

Settlement (finance); Compression (physics); Mean squared error; Index (typography); Empirical modelling; Data compression; Machine learning; Computer science; Artificial intelligence; Data mining; Predictive modelling; Soil water; Mathematics; Property (philosophy)

2026-01-01https://doi.org/10.1007/978-3-032-07738-7_15Studies in systems, decision and control 20261Flexibility optimization from distributed storage resources under stochastic uncertaintiesLílian Venturi Pinheiro; Thiago Ribeiro de Barros; Leonardo Willer De Oliveira; Janaína G. Oliveira; Tiago André Soares; BRUNO HENRIQUES DIAS

Flexibility (engineering); Scheduling (production processes); Energy storage; Photovoltaic system; Distributed generation; Operational planning; Stochastic optimization; Voltage; Stochastic programming; Computer science; Reliability engineering; Engineering; Control engineering; Mathematical optimization; Key (lock); Battery (electricity); Demand response; Mode (computer interface); Stochastic modelling

2026-01-02https://doi.org/10.1016/j.epsr.2025.112674Electric Power Systems Research 20261A inclusão fomentada por um centro de atendimento educacional especializado: Estudo de caso do CRAEDI / Governador Valadares (MG)O conhecimento sobre o Atendimento Educacional Especializado (AEE) e de sua gestão é de suma importância para referendar a formação de professores e gestores escolares, bem como para estabelecer políticas públicas na educação. Neste sentido, esta pesquisa objetiva analisar o papel social do Centro Municipal de Referência e Apoio à Educação Inclusiva (CRAEDI) de Governador Valadares (MG). A pesquisa consiste em um estudo de caso. A escolha do CRAEDI se fundamenta na peculiaridade de que o seu AEE vai além do modelo das salas de recursos multifuncionais, conforme preconizado pelo Decreto 7611/2011 (Brasil, 2011), permitindo o atendimento a todas as escolas a partir de um único centro. Os resultados apontam que o CRAEDI contribui para a inclusão e a melhoria do desenvolvimento cognitivo, social e emocional de crianças com deficiência e com altas habilidades/superdotação nas escolas regulares. Além disso, os alunos do CRAEDI têm maiores chances de ingressar no mercado de trabalho e de participar de atividades sociais, considerando suas expectativas futuras. O êxito das ações do CRAEDI deve-se ao fato de que o princípio da inclusão e da acessibilidade permeia a competência humana de seus profissionais, bem como sua estrutura física, tecnológica e seu Projeto Político Pedagógico.Stela Cristina Hott Corrêa; Silvana Lopes Nogueira; Kascilene Gonçalves Machado

Decree; Work (physics); Citizenship; Order (exchange); Humanities; Philosophy; Sociology

2026-01-02https://doi.org/10.21527/2179-1309.2026.123.16185Revista Contexto & Educação 20261Comparação entre os efeitos de diferentes protocolos de treinamento resistido sobre parâmetros cardiovasculares clínicos e ambulatoriais de idosos hipertensosIntroduction: Resistance training (RT) promotes numerous musculoskeletal and functional benefits and is recommended for elderly hypertensive subjects. The effects of RT with blood flow restriction (BFR) have been little investigated in this population. Objective: To compare the effects of RT recommended by the Brazilian Guidelines for Arterial Hypertension and RT with RFS on clinical and ambulatory cardiovascular variables of elderly hypertensive subjects. Methodology: Hypertensive elderly subjects were randomly divided into two experimental groups: Without RFS (N=14) and With RFS (N=13). The groups underwent an intervention period (10 weeks of RT, 2 sessions/week, 4 exercises performed unilaterally, 3 sets until moderate fatigue, with a 90s interval between sets). The Without RFS Group performed RT at an intensity of 50% of 1RM. The With RFS Group performed RT at an intensity of 30% of 1RM and with cuffs inflated to 70% of the total blood flow occlusion pressure. Before and after the intervention period, the volunteers underwent assessment of blood pressure and heart rate in clinical and ambulatory conditions. Results: Compared to pre-intervention values, none of the RT types promoted clinical and ambulatory cardiovascular changes (P>0.05). No significant differences were observed between the two experimental groups (P>0.05). Conclusions: It is concluded that none of the intervention types promoted clinical and ambulatory cardiovascular changes, so there was no difference between the effects of RT recommended by the Brazilian Guidelines for Arterial Hypertension and RT with RFS in elderly hypertensive subjects.Diego Alves dos Santos; Ciro José Brito; Danielle Lorentz Villaça; Alex Sandro Seccato; Susana América Ferreira; Diego Ignácio Valenzuela Pérez; Cláudia Lúcia De Moraes Forjaz; Andréia Cristiane Carrenho Queiroz

Ambulatory; Ambulatory blood pressure; Blood pressure; Resistance training; Hemodynamics; Heart rate; Medicine; Cardiology; Physical therapy; Internal medicine; Intensity (physics); Blood flow; Surgery; Significant difference

2026-01-03https://doi.org/10.47197/retos.v75.113245Retos 20261Further insights in the relationship between religiosity and telomere lengthJuliane Piasseschi de Bernardin Gonçalves; Thais Chile; Vanessa J.R. de Paula; Marcus Zulian Teixeira; Salma Rose Ribeiz; Martin Schalling; Geraldo F. Busatto; Giancarlo Lucchetti; Homero Vallada

Religiosity; Telomere; Cellular Aging; MEDLINE; Psychology; Genetics; Developmental psychology; Biology

2026-01-03https://doi.org/10.1016/j.jpsychores.2026.112517Journal of Psychosomatic Research 20261Spiropyran-Modified Cellulose for Dual Solvent and Acid/Base Vapor SensingStimuli-responsive materials based on renewable biopolymers are highly attractive for developing sustainable chemical sensors. Here, two spiropyran derivatives (SP1 and SP2) were synthesized and covalently grafted onto cellulose, yielding the functional materials Cel-SP1 and Cel-SP2. Cellulose was selected as a biocompatible, biodegradable, and renewable support able to provide a stable, hydrogen-bond-rich microenvironment for chromic responses. Raman spectroscopy confirmed successful esterification, while SEM-EDS analyses revealed preserved cellulose morphology and the incorporation of nitrogen-rich spiropyran moieties. Both materials exhibited pronounced solvatochromic and pH-dependent behaviors in the solid state. Diffuse reflectance measurements revealed distinct bathochromic or hypsochromic shifts depending on solvent polarity and specific solute–matrix interactions, with DMF and DMSO producing the strongest responses. Under acidic vapors, both materials generated new absorption bands consistent with the formation of protonated merocyanine species, whereas basic vapors promoted partial or full reversion to the spiropyran form. Cel-SP1 and Cel-SP2 also displayed solvent- and pH-dependent luminescence, with Cel-SP2 showing a markedly higher sensitivity to protonation. Prototype solvent strips and acid/base vapor indicators demonstrated fast, naked-eye, reversible chromic transitions. These results highlight spiropyran-modified cellulose as an effective, renewable platform for dual solvent and acid/base vapor sensing.Daniel D. S. de Sá; João P. C. Trigueiro; Luiz F. C. de Oliveira; Hernane Silva Barud; Frank Alexis; Roberto S. Nobuyasu; Flávio B. Miguez; Frederico B. De Sousa

Spiropyran; Solvatochromism; Cellulose; Solvent; Hypsochromic shift; Raman spectroscopy; Absorption (acoustics); Materials science; Photochemistry; Chemical engineering; Chemistry; Absorption spectroscopy; Spectroscopy; Merocyanine; Bathochromic shift; Organic chemistry

2026-01-04https://doi.org/10.3390/chemosensors14010017Chemosensors 20261Quality of life in university professors: association with components of spirituality and professional achievementBackground University professors face considerable workload pressures and professional demands that can negatively affect their quality of life (QoL). Positive emotions associated with spirituality and religiousness (S/R) have been linked to enhanced QoL in various populations; however, limited research has explored this relationship among university professors. Objective To examine the association between spirituality/religiousness and quality of life among university professors, identifying the most influential spiritual facets and relevant sociodemographic predictors. Methods This cross-sectional study included 213 professors from a public university in Goiás, Brazil. Participants completed the WHOQOL-BREF (QoL) and WHOQOL-SRPB (S/R) instruments, both validated for the Brazilian population. Results Seven of the eight S/R facets showed significant positive correlations ( p ≤ 0.01) with QoL domains. The strongest associations were observed in the psychological domain, particularly for hope and optimism ( r = 0.67), spiritual strength ( r = 0.62), and faith ( r = 0.59). Regression analyses indicated that these facets were the strongest independent predictors of overall QoL ( R 2 = 0.28). Professional and sociodemographic factors such as academic degree, job satisfaction, professional recognition, and income were also associated with higher QoL, while holding multiple employment contracts was inversely related to it. Conclusion Higher levels of S/R were positively associated with QoL among university professors. These findings highlight the potential value of integrating spirituality-based activities into university wellness programs as effective strategies to promote well-being and help faculty manage occupational demands.Cezimar Correia Borges; Renata Custódio Maciel; Uitarany do Prado Lemes; Matias Noll; María Alves Barbosa; Celmo Celeno Porto; PATRÍCIA ROBERTA DOS SANTOS; Giancarlo Lucchetti; Weder Alves da Silva; Celaine Ribeiro; Vicente Aprigliano; Marina Silveira; Gerson Ferrari; Alberto Souza Sá Filho

Spirituality; Association (psychology); Quality of life (healthcare); Value (mathematics); Well-being; Quality (philosophy); Student life; Psychology; Clinical psychology; Medical education; Applied psychology; Gerontology

2026-01-05https://doi.org/10.3389/fpsyg.2025.1735377Frontiers in Psychology 20261Das técnicas de costura às técnicas de siEste trabalho investiga as relações entre moda, técnica e pensamento filosófico, a partir da elaboração de uma coleção autoral composta por vinte looks, dividida em quatro famílias conceituais, inspiradas na obra de Michel Foucault. O objetivo deste artigo é apresentar o desenvolvimento da referida coleção e refletir sobre como a moda, enquanto linguagem e prática técnica, pode incorporar discursos teóricos e conceituais, neste caso, no que tange aos conceitos foucaultianos de poder, controle, panoptismo, disciplina, subjetividade, resistência, verdade e parresía. Trata-se, possivelmente, da primeira coleção de moda autoral a tomar a obra de Michel Foucault como eixo conceitual e estético, propondo um diálogo inédito entre o pensamento foucaultiano e os processos criativos no campo da moda. A metodologia adotada segue os princípios propostos por Doris Treptow para o desenvolvimento de coleções de moda, articulando pesquisa de tendências, definição de público-alvo, cartela de cores, escolha de materiais e construção das roupas. As análises foram realizadas a partir das fotografias dos looks confeccionados, permitindo observar como os conceitos foucaultianos foram traduzidos em forma, textura e modelagem a partir das técnicas da moda. Os resultados apontam que a moda pode atuar como meio crítico e expressivo, capaz de desestabilizar convenções sociais, fomentar a emergência de novas subjetividades e engendrar experiências estéticas comprometidas com o pensamento. Dessa forma, o estudo contribui para expandir as articulações possíveis entre teoria e prática, inserindo a criação de moda no campo das elaborações conceituais e nos debates sobre as técnicas que a constituem.Marcelino Gomes dos Santos; Durval Muniz de Albuquerque Júnior; Aline Gabriel Freire

Michel foucault; Field (mathematics); Politics; Context (archaeology); Subject (documents); Relation (database); Philosophy; Humanities; Sociology

2026-01-01https://doi.org/10.5965/1982615x19472026077Modapalavra e-periódico 20261Ultrasound-assisted Hydration Improves Germination and Early Growth of Moringa oleifera Under Salinity StressMateus Aparecido dos Santos; Flaviana Coelho Pacheco; Moisés Henrique Almeida Gusmão; Irene Andressa; Ana Flávia Coelho Pacheco; Paulo Henrique Costa Paiva; Fernando Teixeira Gomes

Seedling; Germination; Moringa; Radicle; Salinity; Saline; Seed treatment; Abiotic component; Agronomy; Biology; Horticulture; Chemistry; Osmotic pressure

2026-01-05https://doi.org/10.1007/s42729-025-02978-9Journal of soil science and plant nutrition 20261Prevalence of and factors associated with sarcopenia in patients on hemodialysis in Brazil: findings from the multicenter SARC-HD studyObjective: The understanding of sarcopenia in patients on hemodialysis from middle-income countries remains underexplored. We investigated the prevalence of and factors associated with sarcopenia in patients undergoing hemodialysis in Brazil. Methods: (SARC-HD) multicenter study. Muscle strength was assessed by handgrip, muscle mass by calf circumference, and physical performance by the 4-m gait speed test. Sarcopenia was diagnosed and staged as probable, confirmed, or severe based on the revised European Working Group on Sarcopenia in Older People (EWGSOP2) consensus. Associated factors were investigated with adjustment for potential confounders. Results: A total of 983 patients (median age 59 years; 48% ≥ 60 years; 40% female) from 19 dialysis centers were analyzed. The prevalences of probable, confirmed, and severe sarcopenia were 12, 9, and 5%, respectively. Sarcopenia prevalence increased with age, ranging from 7 to 45% in the male individuals and from 4 to 21% in the female individuals. In the fully adjusted model, older age [≥60 years; adjusted odds ratio (aOR): 3.30, 95% confidence interval (CI): 2.09-5.21], male sex (aOR: 1.77, 95% CI: 1.13-2.77), white ethnicity (aOR: 1.88, 95% CI: 1.23-2.87), and diabetes as the etiology/comorbidity of chronic kidney disease (CKD) (aOR: 1.83, 95% CI: 1.20-2.91) were independently associated with higher odds of sarcopenia. Nevertheless, overweight (aOR: 0.38, 95% CI: 0.24-0.60) and obesity (aOR: 0.11, 95% CI: 0.05-0.26) were associated with lower odds. After sensitivity analyses based on dialysis prescription, only older age, white ethnicity, overweight, and obesity remained independently associated with sarcopenia. Conclusion: One in four patients on hemodialysis had some stage of sarcopenia. Independent risk factors associated with sarcopenia were older age and white ethnicity, whereas overweight and obesity were protective factors. These findings may help identify hemodialysis patients at increased risk of sarcopenia, thereby promoting early screening, diagnosis, and treatment strategies.Marvery Peterson Pinheiro Duarte; Otavio NOBREGA; Barbara P. Vogt; Marina S. Pereira; Fábio A. Vieira; Maryanne Z. C. Silva; Henrique S. Disessa; Dario R. Mondini; Rodrigo Rosso Krug; Bruna M. Sant’Helena; Daiana Cristine Bündchen; M. Böhlke; Angélica Nickel Adamoli; Ricardo Moreno Lima; Antônio J. Inda‐Filho; Carla María Avesani; Maycon Moura Reboredo; Heitor S. Ribeiro; the SARC-HD Study Group

Hemodialysis; Sarcopenia; Overweight; Multicenter study; Obesity; Risk factor; Comorbidity; Medicine; Internal medicine; Incidence (geometry); Risk assessment; Intensive care medicine

2026-01-05https://doi.org/10.3389/fmed.2025.1671237Frontiers in Medicine 20261One-year results of XEN 45® gel stent in open-angle glaucoma and its impact on glaucoma medication-related costsR.A.P. Guedes; D.A.G. Moraes; D.M. Gravina; V.M.P. Guedes; A. Chaoubah

Glaucoma; Stent; Reduction (mathematics); Intraocular pressure; Glaucoma surgery; Visual field; Medicine; Ophthalmology; Surgery; Eye disease

2026-01-05https://doi.org/10.1016/j.jfo.2025.104750Journal Français d Ophtalmologie 20261Unequal Burdens, Unequal Pay: Household Chores and Wages in BrazilManuela La Rosa; Flaviane Souza Santiago; Kênia Barreiro de Souza

Affect (linguistics); Wage; Face (sociological concept); Working hours; Time allocation; Labour economics; Economics; Demographic economics

2026-01-07https://doi.org/10.21203/rs.3.rs-8158483/v1Research Square 20261The relative age effect in Brazilian national basketball teams over timeIntroduction In basketball, identifying and developing potential athletes is crucial, and the Relative Age Effect (RAE) plays an important role in this process. However, could this effect interfere in the selection of elite players? Objective The aim of the present study was to evaluate the RAE in Brazilian male and female basketball national teams in official competitions and to examine its association with the competition type, age category and collective performance. Methods A total of 1,585 athletes were analyzed, including 703 males and 882 females. The mean age of the male athletes was 20.99 years old (±5.80), and their mean height was 196.72 cm (±9.36), while the female athletes had a mean age of 20.83 years old (±5.80) and a mean height of 179.00 cm (±6.44). The sample consisted of athletes who participated in world and continental competitions between 2002 and 2023, in the U15, U16, U17, U18, U19 and senior categories. The data were collected from the International Basketball Federation's website ( https://www.fiba.basketball ). Athletes' months of birth were categorized into quartiles and semesters, and the medalists and non-medalists team performance was analyzed, considering world and continental competitions besides youth vs. senior categories. To investigate the RAE across categories, the Chi-Square ( χ 2 ) test for quartiles was applied. To analyze the association of the RAE (semester) with competition type, outcome and category, the Chi-Square ( χ 2 ) test was used as well. Results The findings revealed a significant presence of the RAE ( p &lt; 0.001) across all groups analyzed, regardless of gender, competition type, category or team performance. No associations were observed between semester of birth and competition type or team performance for either gender. Regarding category type, a significant association was found between being born in the first semester and participating in youth competitions for males ( p = 0.03) and females ( p = 0.003). Conclusion The RAE is present at the elite level of Brazilian basketball over time, showing association only with the type of category.M. M. Pereira; Francisco Zacaron Werneck; Gabriel Torres da Silva; Hélder Zimmermann Oliveira; Lívia Costa dos Reis Souza; Pedro Silva Carvalho; Davi Romeiro Soares Alves; Dilson Borges Ribeiro Junior

Basketball; Elite; Association (psychology); Athletes; League; Psychology; Demography

2026-01-06https://doi.org/10.3389/fspor.2025.1716826Frontiers in Sports and Active Living 20261Brazilian Society of Surgical Oncology: Guidelines and Consensus Statement for Palliative Surgery in OncologyBACKGROUND AND OBJECTIVE: Palliative surgery in oncology aims to relieve symptoms, improve quality of life, and respect patient autonomy in advanced cancer. This study aimed to develop evidence-based recommendations for safely indicating and performing palliative surgeries in Brazil, considering clinical, ethical, and multidisciplinary aspects. METHODS: A modified Delphi consensus was conducted with nine experts from the Brazilian Society of Surgical Oncology, including surgical and clinical oncologists, palliative care specialists, and a psychologist. Sixteen key recommendations were formulated based on literature review and a national survey identifying gaps in training, communication, and technical safety. Consensus was defined as ≥ 80% agreement, achieved in a single round. RESULTS: Recommendations emphasize individualized patient selection based on functional status, frailty, prognosis, and symptom severity. Multidisciplinary evaluation, shared decision-making, clear communication, and consideration of minimally invasive techniques were prioritized. Palliative procedures focus on symptom control rather than survival extension, with evidence supporting improved quality of life, reduced hospital admissions, and enhanced oral intake. CONCLUSIONS: Palliative surgery should be guided by strict clinical criteria, multidisciplinary planning, and patient-centered communication. Active patient participation, ethical deliberation, and evidence-based practices ensure safe, effective, and humanized care, avoiding futile or disproportionate interventions.Audrey Cabral Ferreira de Oliveira; J Hammes; Isabela Maria Alves de Almeida Oliva; Lara Andrade Mendes Mangieri; Ronald Enrique Delgado Bocanegra; Marcos Gonçalves Adriano; Ana Caroline Fonseca Alves; Eliel Oliveira de Araújo; Jairo Cerqueira de Almeida Teixeira; Patricia Isabel Bahia Mendes Freire; Larissa de Jesus Almeida; Raquel Lacerda Dantas de Farias; Heládio Feitosa e Castro Neto; Alexandre Ferreira Oliveira; R Ribeiro; Rodrigo Nascimento Pinheiro

Palliative surgery; Statement (logic); Multidisciplinary approach; Palliative care; Surgical oncology; Multidisciplinary team; MEDLINE; Compassionate Use; Medicine; General surgery; Intensive care medicine; Cancer surgery; Position statement; Surgery; Oncologic surgery; Palliative treatment; Palliative Therapy; Family medicine

2026-01-07https://doi.org/10.1002/jso.70189Journal of Surgical Oncology 20261Raw data, photographs and R scripts for the study of socio-ecological seed exchange networks in quilombola communities, BrazilThis repository contains the raw data, photographs, and R scripts used in the study “Socio-agronomic features define the structure of socio-ecological seed exchange networks”. Data were collected through ethnographic and ethnobotanical fieldwork conducted in five quilombola communities located in the rural area of Mariana, Minas Gerais, Brazil. The dataset includes raw interview data, information on seed varieties and crops exchanged, socio-agronomic attributes of participants, and relational data used to construct socio-ecological seed exchange networks. Photographic records document seeds, crops, and fieldwork contexts, supporting qualitative interpretation and transparency of the research process. The R scripts provided reproduce the analytical workflow applied in the associated article, including data organization, network construction, calculation of network metrics, and statistical analyses. This dataset is published to ensure transparency, reproducibility, and reuse of ethnobiological data related to agrobiodiversity conservation and traditional seed exchange systems.Isabella Fernandes Fantini; Gustavo Taboada Soldati; Felipe Costa

Scripting language; Workflow; Relational database; Raw data; Ethnobotany; Reuse; Transparency (behavior); Construct (python library); Computer science; Geography; World Wide Web; Database; Qualitative research; Metadata; Agricultural biodiversity; Ethnography

2026-01-06https://doi.org/10.5281/zenodo.18166370Zenodo (CERN European Organization for Nuclear Research) 20261On the Stability of Foam Displacement Simulations in Porous MediaP. Z. S. Paz; F. A. N. Obiang; F. F. de Paula; Grigori Chapiro

Porous medium; Saturation (graph theory); Discretization; Viscosity; Displacement (psychology); Amplitude; Hydrogeology; Porosity; Materials science; Mechanics; Permeability (electromagnetism); Stability (learning theory); Shock (circulatory); Computer simulation; Numerical analysis; Enhanced oil recovery; Viscous fingering; Shock wave; Numerical stability; Void (composites)

2026-01-07https://doi.org/10.1007/s11242-025-02277-yTransport in Porous Media 20261Table S1. Supplementary table for Oliveira et al. 2026. Updated distribution range of two worm lizard species (Amphisbaena alba and A. fuliginosa) based on citizen science and literature review. Reptiles & Amphibians, 33(1).Table S1. Supplementary table containing records of occurrence of Amphisbaena alba and Amphisbaena fuliginosa (Squamata: Amphisbaenidae).J. Oliveira Henrique; Nocelli Vanessa; C. Costa Henrique

Table (database); Lizard; Range (aeronautics); Sauria; Citizen science; Geography; Ecology; Distribution (mathematics); Zoology

2026-01-06https://doi.org/10.5281/zenodo.18162937Zenodo (CERN European Organization for Nuclear Research) 20261Comparison of Uncemented and Hybrid Hip Arthroplasty: Protocol for a Brazilian Randomized Controlled TrialBackground: Total hip arthroplasty is a highly successful procedure for treating hip arthritis, improving patients' pain, function, and quality of life (QoL). Scarce publications on total hip arthroplasty performance using Brazilian-manufactured materials report results comparable to those from other countries. Objective: The aim of this study is to compare the clinical, radiographic, functional, pain, and QoL outcomes of patients who underwent surgery with a national hybrid prosthesis (with femoral cementation) versus patients who underwent surgery with a national uncemented prosthesis. Methods: This study is a single-center, single-surgeon, single-approach, pragmatic, double-blinded, and prospective randomized trial. A total of 120 patients will be enrolled and randomly allocated in a 1:1 ratio to 2 groups: the hybrid group and the uncemented group. The incidence of complications (during and after surgery) and the restoration of normal anatomical parameters on postoperative radiographs will be assessed using radiographic parameters. Participants' QoL, joint mobility, function, and satisfaction will be evaluated using the 12-Item Short Form Health Survey version 2 questionnaire, hip range of motion, the Harris Hip Score, and a numeric rating scale. Prosthesis survival will be analyzed using the annual revision surgery rate from 1 to 5 years, and up to 10 years. Results: The project did not receive external funding. Data collection began in October 2024 and is ongoing, with completion expected in December 2029. As of April 2025, 72 participants have been enrolled. Preliminary data analysis has been initiated and is ongoing. The first results are expected to be published in the first half of 2026. Conclusions: This study is a pragmatic clinical trial that uses blinding to evaluate national implants for both hybrid and uncemented hip arthroplasty. Successful completion of this study may provide clinical evidence on the performance of national implants and identify a preferred implant construct (hybrid or uncemented), if any, for hip replacement in Brazil.Bruno Gonçalves Schröder e Souza; ISABELLA DIAS LACERDA; MATHEUS MALTA VASCONCELOS; NATHÁLIA LACERDA FURTADO; Julia Machado Vieira; Iasmim Sand Ferreira de Souza; Marco Antônio Perígolo Magalhães; Leonã Aparecido Homem do Amaral; Luiz Guilherme Vidal Assad; Carlos Henrique Cavaglieri Silveira Silva; Carolina Tsen; Valdeci Manoel de Oliveira

Randomized controlled trial; Protocol (science); Hip arthroplasty; Arthroplasty; Total hip arthroplasty; Randomization; Medicine; Physical therapy; Surgery; Hip surgery; MEDLINE

2026-01-07https://doi.org/10.2196/79721JMIR Research Protocols 20261Raw data, photographs and R scripts for the study of socio-ecological seed exchange networks in quilombola communities, BrazilThis repository contains the raw data, photographs, and R scripts used in the study “Socio-agronomic features define the structure of socio-ecological seed exchange networks”. Data were collected through ethnographic and ethnobotanical fieldwork conducted in five quilombola communities located in the rural area of Mariana, Minas Gerais, Brazil. The dataset includes raw interview data, information on seed varieties and crops exchanged, socio-agronomic attributes of participants, and relational data used to construct socio-ecological seed exchange networks. Photographic records document seeds, crops, and fieldwork contexts, supporting qualitative interpretation and transparency of the research process. The R scripts provided reproduce the analytical workflow applied in the associated article, including data organization, network construction, calculation of network metrics, and statistical analyses. This dataset is published to ensure transparency, reproducibility, and reuse of ethnobiological data related to agrobiodiversity conservation and traditional seed exchange systems.Isabella Fernandes Fantini; Gustavo Taboada Soldati; Felipe Costa

2026-01-06https://doi.org/10.5281/zenodo.18166369Zenodo (CERN European Organization for Nuclear Research) 20261Hierarchical Analysis of Physical Activity Determinants in Brazilian Adolescents: A Cross-Sectional StudyBackground: Physical inactivity during adolescence remains a major public health concern, yet its multifactorial determinants are not fully understood in low- and middle-income settings. Objective: To identify and quantify the determinants of physical activity (PA) among Brazilian adolescents using a hierarchical logistic regression model that reflects the theoretical ordering of distal to proximal factors. Methods: A cross-sectional study was conducted with 856 adolescents (13–19 years). Data were obtained from the validated Brazilian Youth Risk Behavior Survey and the Brazilian Economic Classification Criteria (ABEP) socioeconomic questionnaire. PA was dichotomized according to World Health Organization recommendations. Hierarchical logistic regression examined five theoretical blocks: sociodemographic, anthropometric, substance use, weight/diet, and sedentary behavior. Results: Overall, 5 out of 17 predictors were significant in the full model. extended Body mass index (eBMI) was negatively associated with physical activity (OR = 0.331, 95% CI: 0.169–0.647, p = 0.001), while body mass was positively associated (OR = 2.078, 95% CI: 1.045–4.135, p = 0.037). Working status (OR = 1.235, 95% CI: 1.035–1.475, p = 0.019) and weight loss attempts (OR = 1.327, 95% CI: 1.042–1.690, p = 0.022) increased the odds of being active, whereas current smoking reduced it (OR = 0.715, 95% CI: 0.517–0.990, p = 0.043). Model discrimination improved progressively (AUC = 0.577 to 0.692). Conclusions: Physical activity among Brazilian adolescents was primarily influenced by behavioral and perceptual rather than demographic factors. These findings highlight the need for integrated interventions promoting muscle development, body positivity, and smoking prevention.Arley Santos Leão; Roberto Jerônimo dos Santos Silva; N. Almeida; Cinthya Luiza Rezende Oliveira; Diego Ignácio Valenzuela Pérez; Esteban Aedo–Muñoz; Ciro José Brito; Júlio Manuel Cardoso Martins; Aldo Matos da Costa

Physical activity; Psychological intervention; Perception; Multilevel model; Motor activity; Psychology; Environmental health; Gerontology

2026-01-08https://doi.org/10.3390/sports14010031Sports 20261Costureiras de bairro e a vida multicosturaEste artigo tem como objetivo abordar tipos generalizados de técnicas de costura, industrial, artesanal e doméstica, para discutir a possibilidade de existência de multicosturas em um mundo dominado por uma monocostura industrial. A partir do diálogo entre as teorias de Heidegger (2006 [1953]) e Hui (2020), sobre a técnica no mundo moderno, e de pesquisas que investigam costureiras no Brasil, este trabalho coloca em perspectiva o lugar técnico deste ofício. Este exercício leva a reflexão sobre a possibilidade de “costureiras de bairro” exercerem múltiplas técnicas de costura simultaneamente, considerando suas práticas heterogêneas, desenvolvidas em suas trajetórias, principalmente por não ser uma profissão institucionalizada. Julga-se as práticas das “costureiras de bairro” um importante objeto de estudo em relação a técnica na moda e no vestuário. O estudo sugere que uma perspectiva de tempo não linear acerca das técnicas de costura, como se apresenta na maioria das referências bibliográficas do campo da moda, como alta-costura > prêt-à-porter > fast-fashion, seja capaz de resgatar outros modos de costura.Eliza Dias Möller; Elisabeth Murilho da Silva

Perspective (graphical); Field (mathematics); Object (grammar); Subject (documents); Feeling; Context (archaeology); Perception; Argument (complex analysis); Cognition; Focus (optics); Sociology; Epistemology; Humanities; Qualitative research; Set (abstract data type); Exploratory research

2026-01-01https://doi.org/10.5965/1982615x19472026047Modapalavra e-periódico 20261AVALIAÇÃO DO DESEMPENHO DE UM SISTEMA DE FILTRAÇÃO EM MÚLTIPLAS ETAPAS NO TRATAMENTO DA ÁGUA DE UMA ESCOLA RURALO Brasil enfrenta muitos desafios em assegurar o acesso universal à água potável, o que fica refletido nos altos índices de doenças de veiculação hídrica do país. A situação é mais crítica nas áreas rurais, que se diferem dos centros urbanos em muitos aspectos e necessitam de tecnologias apropriadas. Este estudo de caso visa avaliar o desempenho de um sistema de Filtração em Múltiplas Etapas (FiME) implementado em uma escola da área rural, de forma a alcançar as exigências da portaria de potabilidade da água de consumo. A avaliação do tratamento da água envolveu análises laboratoriais da água bruta, filtrada e após desinfecção, durante o ano de 2023. Os parâmetros de qualidade analisados foram: cor aparente, turbidez, pH, temperatura, ferro, fósforo, cloro residual livre e E. coli. O sistema FiME, demonstrou excelente desempenho com eficiência de remoção de E. coli em torno de 80%. As análises da água bruta confirmaram a compatibilidade da qualidade da água com as exigências do sistema de tratamento, mesmo diante das alterações em suas características devido às diferenças no regime de chuva durante o período de um ano, evidenciando sua adequabilidade ao cenário rural. Já as análises da água tratada confirmaram a eficiência do sistema em produzir água potável. O monitoramento do sistema permitiu determinar a periodicidade para limpeza do filtro em aproximadamente quatro meses, para manutenção do bom funcionamento, além de confirmar a necessidade da etapa de desinfecção.Bruna Ruback; Renata de Oliveira Pereira; Paula Rafaela Silva Fonseca; Fernanda Deister Moreira

Context (archaeology); Limiting; Quality (philosophy); Political science; Humanities

2026-01-08https://doi.org/10.9771/gesta.v0i3.66717Revista Eletrônica de Gestão e Tecnologias Ambientais 20261Rehabilitation using non-conventional implants with zygomatic anchorage: case reportRehabilitation in the atrophic maxilla is considered a challenge due to the difficulty of achieving anchorage for conventional implants in conditions of structural bone deficiency. Furthermore, alternative approaches for implant-supported rehabilitation have been developed to increase predictability and reduce the need for bone remodeling procedures. In this case report, a patient with severe bone loss underwent an alternative oral rehabilitation technique using zygomatic, transnasal, and pterygoid implants, restoring both functional and aesthetic aspects. The methodology employed proved to be effective and safe when properly indicated.Marcelo Gabriel de Oliveira; Rafael Espinoza Nieves; Thiago Borges Mattos; Lidia Batista Conrado Martins; Paola Ferreira Galito; Ive Couto

Rehabilitation; Maxilla; Reduction (mathematics); Zygomatic bone; Prosthesis; Medicine; Orthodontics; Dentistry

2026-01-08https://doi.org/10.52641/cadcajv11i1.1503Cadernos Cajuína 2026171 In vitro embryo production using yeast extract to replace fetal calf serum: effects on embryo quality and pregnancy ratesL. A. G. Martinhao; J. G. V. Grazia; L. A. Martins; O. A. C. Faria; D. N. Ribas; I. N. Garcia; J. H. M. Viana

Reproductive technology; Embryo culture; Embryo; Embryo quality; Fetus; Pregnancy; Oogenesis; Reproductive immunology; Yeast; Biology; Andrology; Fertilisation; In vitro; In vitro fertilisation; Embryo cryopreservation; Pregnancy rate; Cryopreservation; Embryo transfer; Folliculogenesis; Gametogenesis

2026-01-08https://doi.org/10.1071/rdv38n1ab71Reproduction Fertility and Development 20261FERRAMENTA AUTOMATIZADA PARA MONITORAMENTO ASSISTENCIAL DE ARBOVIROSES NA ATENÇÃO PRIMÁRIA À SAÚDEAs arboviroses configuram-se como importante desafio para a saúde pública, especialmente em municípios de médio porte como Juiz de Fora-MG, onde fatores ambientais, climáticos e sociais favorecem a circulação de vírus como dengue, chikungunya e oropouche. Na Atenção Primária à Saúde (APS), compreender o impacto dessas doenças na demanda assistencial é essencial para apoiar a organização dos serviços, a alocação de recursos e o planejamento de respostas rápidas. Até a experiência relatada, o processo decisório municipal baseava-se quase exclusivamente em indicadores epidemiológicos, sem monitoramento sistemático de indicadores assistenciais. Nesse contexto, desenvolveu-se um estudo metodológico que contemplou elaboração e implantação de uma ferramenta automatizada, elaborada no Google Sheets, alimentada por dados do e-SUS APS extraídos em formato CSV. A lógica de cálculo contemplou série histórica de 2020 a 2025, abrangendo atendimentos e procedimentos relacionados às arboviroses, incluindo provas diagnósticas, registros por CIAP-2 e CID-10 e atividades coletivas de combate ao Aedes aegypti. Como resultados, a ferramenta qualificou a agilidade das análises, reduziu a necessidade de manipulação manual e fortaleceu a capacidade da APS de identificar variações sazonais, subsidiando estratégias de resposta e decisões intersetoriais. Evidenciou-se ainda potencial de replicabilidade, por demandar apenas recursos amplamente disponíveis e permitir adaptação para outros agravos. Como considerações finais, verificou-se que é possível, com baixo custo e tecnologias acessíveis, aprimorar o monitoramento assistencial, fortalecer a integração entre vigilância e atenção e consolidar um modelo metodológico aplicável em diferentes contextos, contribuindo para a gestão em saúde e para a resolutividade da APS. Trata-se de produto da monografia de conclusão de curso da Especialização em Saúde Coletiva na área de concentração Saúde Digital da Universidade Federal da Bahia, a ser defendido em 2026.Cosme Rezende Laurindo

Chikungunya fever; Medical care; Health services; Medicine; Gynecology; Physics

2026-01-08https://doi.org/10.5281/zenodo.18180922Zenodo (CERN European Organization for Nuclear Research) 20261Global occurrence of perfluorooctane sulfonate and perfluorooctanoic acid in waters: systematic review and preliminary health risk assessmentT. O. G. Assunção; G. A. R. Kelmer; R. O. Pereira

Perfluorooctanoic acid; Perfluorooctane; Sulfonate; Risk assessment; Human health; Water quality; Environmental health; Environmental chemistry; Chemistry; Environmental science; Public health; Legislation

2026-01-08https://doi.org/10.1007/s42108-025-00471-8International Journal of Energy and Water Resources 20261FERRAMENTA AUTOMATIZADA PARA MONITORAMENTO ASSISTENCIAL DE ARBOVIROSES NA ATENÇÃO PRIMÁRIA À SAÚDEAs arboviroses configuram-se como importante desafio para a saúde pública, especialmente em municípios de médio porte como Juiz de Fora-MG, onde fatores ambientais, climáticos e sociais favorecem a circulação de vírus como dengue, chikungunya e oropouche. Na Atenção Primária à Saúde (APS), compreender o impacto dessas doenças na demanda assistencial é essencial para apoiar a organização dos serviços, a alocação de recursos e o planejamento de respostas rápidas. Até a experiência relatada, o processo decisório municipal baseava-se quase exclusivamente em indicadores epidemiológicos, sem monitoramento sistemático de indicadores assistenciais. Nesse contexto, desenvolveu-se um estudo metodológico que contemplou elaboração e implantação de uma ferramenta automatizada, elaborada no Google Sheets, alimentada por dados do e-SUS APS extraídos em formato CSV. A lógica de cálculo contemplou série histórica de 2020 a 2025, abrangendo atendimentos e procedimentos relacionados às arboviroses, incluindo provas diagnósticas, registros por CIAP-2 e CID-10 e atividades coletivas de combate ao Aedes aegypti. Como resultados, a ferramenta qualificou a agilidade das análises, reduziu a necessidade de manipulação manual e fortaleceu a capacidade da APS de identificar variações sazonais, subsidiando estratégias de resposta e decisões intersetoriais. Evidenciou-se ainda potencial de replicabilidade, por demandar apenas recursos amplamente disponíveis e permitir adaptação para outros agravos. Como considerações finais, verificou-se que é possível, com baixo custo e tecnologias acessíveis, aprimorar o monitoramento assistencial, fortalecer a integração entre vigilância e atenção e consolidar um modelo metodológico aplicável em diferentes contextos, contribuindo para a gestão em saúde e para a resolutividade da APS. Trata-se de produto da monografia de conclusão de curso da Especialização em Saúde Coletiva na área de concentração Saúde Digital da Universidade Federal da Bahia, a ser defendido em 2026.Cosme Rezende Laurindo

Chikungunya fever; Medical care; Health services; Medicine; Gynecology; Physics

2026-01-08https://doi.org/10.5281/zenodo.18180923Zenodo (CERN European Organization for Nuclear Research) 20261124 CRISPR electroporation of bovine zygotes for beta-lactoglobulin gene editing: embryo viability following handmade biopsy and impact on gene analysisC. D. Vieira; H. P. Pereira; E. D. Souza; L. C. Brandt Jesus; N. Z. Saraiva; C. S. Oliveira; L. S. A. Camargo

Electroporation; Reproductive technology; CRISPR; Embryo culture; Zygote; Transgenesis; Embryo; Gene; Biology; Reproductive immunology; Theriogenology; Genetics; Oogenesis; Biopsy; Molecular biology; Genome editing; Cell biology; Embryonic stem cell

2026-01-08https://doi.org/10.1071/rdv38n1ab124Reproduction Fertility and Development 20261Hematopoietic cell transplantation outcomes in public centers in Brazil: analysis of the Brazilian Registry of Hematopoietic Cell Transplantation and Cellular Therapy, 2012–2024This study provides a national overview of hematopoietic cell transplantation (HCT) outcomes in the Brazil’s public healthcare network, using data consolidated in the Brazilian Registry of Hematopoietic Cell Transplantation and Cellular Therapy (RBTCH-TC). A total of 5,923 first HCTs performed between 2012 and 2024 across 19 public centers were analyzed. Median follow-up among survivors reached 24.5 months, reflecting recent improvements in follow-up completeness and data reliability within the registry. Overall survival, relapse, and non-relapse mortality (NRM) rates were generally consistent with international benchmarks, despite the resource limitations characteristic of a publicly funded system. NRM was concentrated in the first year after allogeneic HCT, whereas relapse remained the predominant cause of late mortality across both autologous and allogeneic procedures. Acute graft versus-host disease (GVHD) was more frequent among recipients of mismatched related and unrelated donors, while chronic GVHD occurred more often in matched related donor transplants. These findings highlight the complexity of transplant care in the public setting and underscore the importance of standardized data collection, integration across centers, and long-term surveillance to support continuous quality improvement. Strengthening national collaborative initiatives such as the RBTCH-TC remains essential for guiding evidence-based strategies and improving patient outcomes throughout Brazil’s public transplant network.Anderson João Simione; CA Silva; Nelson Hamerschlak; Afonso Vigorito; Heliz Regina Alves das Neves; A Seber; Carmem Maria Sales Bonfim Bonfim; Vergílio Antônio Rensi Colturato; Samir Nabhan; Vanderson Geraldo Rocha; George Maurício Navarro Barros; Décio Lerner; Liane Esteves Daudt; Juliana Folloni Fernandes; Marcos Paulo Colella; Alexandre Silvério; Rodolfo Daniel de Almeida Soares; Gustavo Machado Teixeira; Victor Gottardello Zecchin; Abrahão Elias Hallack Neto; Rony Schaffel; Rodolfo Calixto; Simone De Castro Resende Franco; Gianne Donato Costa Veloso; Vaneuza Araújo Moreira Funke; Fernando Barroso Duarte

Hematopoietic cell; Transplantation; Hematopoietic stem cell transplantation; Public health; Disease; Health care; Epidemiology; Medicine; Intensive care medicine; Oncology; Internal medicine; MEDLINE

2026-01-08https://doi.org/10.46765/2675-374x.2025v7n1e317JOURNAL OF BONE MARROW TRANSPLANTATION AND CELLULAR THERAPY 20261Does a Federal Penitentiary impact crime? Evidence from Catanduvas, BrazilThe investment in prison infrastructure is a policy to fight crime. On the other hand, if it influences in the spatial displacement of crime, the construction of a penitentiary may generate negative localized effects. Dispite this, there are few studies evaluating the potential localized effects arising from the establishment of new maximum-security prisons. We use a 24-year longitudinal data on sinthetic control models to estimate the impacts of the construction of the Catanduvas Maximum-Security Penitentiary on homicide rates in its microregion. Furthermore, we combine the observation of spatial spillover effects with the synthetic control methodology to achieve better fit between the pretreatment control and the synthetic unit. Our findings suggest a transient and isolated increase in local homicidies, which support that the prison did not act as a catalyst for long-term local violence.Leonardo Schmitz Mosca; Luiz Pedro Couto Santos Silva; Eduardo Almeida; Marco Antônio Jorge

Prison; Control (management); Spillover effect; Investment (military); Displacement (psychology); Homicide; Public policy; Political science; Economics; Crime control; Public economics; Business; Panel data; Longitudinal data

2026-01-09https://doi.org/10.54766/rberu.v20i1.1128Revista Brasileira de Estudos Regionais e Urbanos 20261Synthetic cannabinoids in hair: a review of recent findings and analytical methods by LC-MS/MSRafaela S. Pereira; Olívia B.O. Moreira; M. Silva de Oliveira; Claudiane Costa Canuto; Diogo O.C. Lemos; Lucas M. Duarte; Silvana Vianna Rodrigues

Synthetic cannabinoids; Forensic toxicology; Drugs of abuse; MEDLINE; Chemistry; Biochemical engineering; Management science

2026-01-09https://doi.org/10.1016/j.aca.2026.345078Analytica Chimica Acta 20261A new way to identify the composition of lipids in milk from different animal species by Raman and infrared spectroscopyThaís Lourenço Oliveira; Gabriela de Paula Oliveira; Luiz Fernando Cappa de Oliveira

Chemometrics; Degree of unsaturation; Raman spectroscopy; Principal component analysis; Absorbance; Animal fat; Fourier transform infrared spectroscopy; Analytical Chemistry (journal); Composition (language); Chemistry; Spectroscopy; Food science; Infrared spectroscopy; Raw milk; Animal species; Chemical composition; Infrared; Chromatography; Lipidomics; Fourier transform; Bovine milk

2026-01-10https://doi.org/10.1016/j.foohum.2026.101009Food and Humanity 20261Sistema Regional de Inovação: Uma análise sobre as configurações científicas e tecnológicas de Minas GeraisTendo em vista o papel da inovação para o desenvolvimento socioeconômico de uma região, os agentes locais que contribuem para as atividades inovativas precisam ser analisados acuradamente. Isso a fim de que ações sejam tomadas de forma precisa e impulsionem o progresso científico e tecnológico da região estudada. Desse modo, o objetivo do trabalho é dimensionar o sistema regional de inovação de Minas Gerais a partir de uma análise de componentes principais. Os resultados permitem classificar as 66 microrregiões mineiras em 4 grupos distintos, nomeadamente: regiões criadoras de conhecimento, regiões urbanas demandantes, regiões rurais com potencial para desenvolvimento e regiões subdesenvolvidas industrialmente. É possível perceber que as microrregiões do estado de Minas Gerais divergem em suas capacidades de criação de conhecimento e em suas estruturas urbanas e industriais. Tal conclusão corrobora a visão corrente de que o cenário inovativo mineiro é desigual e subdesenvolvido tal qual o cenário nacional.Letícia Rodrigues; Rosa Lívia Gonçalves Montenegro; Eduardo Gonçalves

Regional development; Context (archaeology); Work (physics); Local Development; Geography; Political science

2026-01-09https://doi.org/10.54766/rberu.v20i1.1189Revista Brasileira de Estudos Regionais e Urbanos 20261Functional capacity in sickle cell disease: A pilot study with 1-minute sit-to-stand testBACKGROUND: Sickle cell disease, the most prevalent monogenic recessive genetic disorder in the world, is characterized by two main pathogenic mechanisms: vaso-occlusion and hemolysis. These characteristics lead to reduced tolerance to physical exertion and, consequently, a reduced functional capacity which can be assessed using the one-minute sit-to-stand test. Complications from sickle cell disease result in poor quality of life, increased absenteeism from school and work, and impaired social interaction. METHOD: Between January 2023 and April 2024, a pilot cross-sectional study was conducted with sickle cell disease patients aged from 18 to 60 years. The one-minute sit-to-stand test, Borg's perceived exertion scale, and the SF-36 quality of life questionnaire were utilized. Patients were monitored during the test. The sample was dichotomized based on test performance and SF-36 scores. Furthermore, clinical and demographic variables were analyzed. MAIN RESULTS: Fifty-eight individuals participated in the final analysis. The mean age was 29.84 ± 11.20 years; 55.1 % were men, and 79.3 % identified themselves as Black or mixed race. The most prevalent genotype was hemoglobin SS (67.2 %), and 77.5 % were taking Hydroxyurea. The group with a better performance in the one-minute sit-to-stand test showed better quality of life as assessed using the SF-36 questionnaire. CONCLUSION: Functional capacity is a significant factor in the autonomy and quality of life of patients with sickle cell disease. The one-minute sit-to-stand test is a low-cost and easily applicable test, which can contribute to the assessment of functional capacity in the routine follow-up of these patients.Michele Barroso Thomaz; Lucas Fernandes Suassuna; Júlia Campos Fabri; Isabela de Oliveira Araújo; Júlia Carneiro Almeida; Daniela de Oliveira Werneck Rodrigues

Test (biology); Quality of life (healthcare); Cell; Quality (philosophy); Autonomy; Medicine; Intensive care medicine; Physical therapy

2026-01-10https://doi.org/10.1016/j.htct.2025.106230Hematology Transfusion and Cell Therapy 20261New item in the diet of Blacksmith Treefrog (Boana faber) tadpoles in an urban area of southeastern BrazilFig. 1), a medium-sized hylid that is nocturnally active in arboreal habitats and is frequently found in anthropic environments (Eterovick et al. 2020), occurs in eastern and southern Brazil, southeastern Paraguay, and Misiones, Argentina (Frost 2024).Reproduction of B. faber generally occurs between December and March and the benthic tadpoles are black upon hatching and and turn different shades of brown as they develop (Eterovick et al. 2020).On 23 February 2024, we observed tadpoles at stages 22 and 36 (Gosner 1960) identified as B. faber based on morphological characteristics described in Eterovick et al. (2020) and Pezzuti et al. (2021) feeding on floating aquatic macrophytes (Limnobium laevigatum [Hydrocharitaceae] and Lemna aequinoctialis and Spirodela sp.[Araceae]) in a 30-liter aquarium in an urban area of Ritpolis, Minas Gerais, Brazil (-21.0234,-44.3199) (Fig. 2).Boana faber is common in urban areas and it used the aquarium opportunistically for spawning.The tadpoles also fed on unidentified filamentous algae growing on the substrate in the aquarium.No other food was provided.The aquarium, which was not equipped with a pump, heater, or light, was placed 150 cm above the ground in a residential garden explicitly for observing aquatic macrophyte development.Little is known about the diet of larval Boana spp., although Pollo et al. (2019) stated that tadpoles of B. cordobae fed primarily on microalgae in a flouride-rich stream in Argentina.Generally, hylid tadpoles feed primarily on algae (e.g., Santos et al. 2016), although necrophagy has been recorded (e.g., Dias et al. 2021).To the best of our knowledge, however, this is the first report of aquatic macrophytes (angiosperms) in the diet of the larvae of any species of Boana.Glauco Cássio de Sousa Oliveira; Catalina do Nascimento Lopez; Alexandre de Assis Hudson

Urban area; Urban environment; Population; Urban ecosystem; Urbanization; Biology; Ecology; Geography

2026-01-09https://doi.org/10.17161/randa.v33i1.23339Reptiles & Amphibians 20261Um caminho entre dois papasO texto apresenta resultados de pesquisa em torno dos desafios para as igrejas cristãs e suas lideranças, sobretudo para o pontificado de Leão XIV, oriundos dos contextos dos pluralismos socioculturais atuais e das possibilidades de diálogos inter-religiosos. Metodologicamente, eles foram agrupados para análise e apresentação em dois momentos. O primeiro se refere a um breve inventário de experiências de diálogo e cooperação inter-religiosa no pontificado de Francisco, somadas à descrição do caráter aberto e ecumênico de seus pronunciamentos, em especial as encíclicas Laudato Si’ e Fratelli Tutti. No segundo momento, são indicados três passos que podem contribuir no enfrentamento dos desafios no tocante ao pluralismo. Trata-se de esforços em compreender e valorizar a diversidade religiosa, cultivar formas novas, críticas e plurais de conhecimento e estabelecer posturas justas e de efetivo diálogo para além das formalidades eclesiásticas. Abstract: The text presents research findings regarding the challenges faced by Christian churches and their leadership, especially for the pontificate of Leo XIV, arising from the contexts of current sociocultural pluralisms and the possibilities of inter-religious dialogue. Methodologically, these were grouped for analysis and presentation in two parts. The first is a brief inventory of experiences of inter-religious dialogue and cooperation during Pope Francis’s pontificate, combined with a description of the open and ecumenical nature of his statements, particularly the encyclicals Laudato Si’ and Fratelli Tutti. In the second part, three steps are outlined that can contribute to addressing the challenges related to pluralism. These involve efforts to understand and value religious diversity, cultivate new, critical, and plural forms of knowledge, and establish fair and effective dialogue postures beyond ecclesiastical formalities. Keywords: Interreligious dialogue; Pope Francis; Pope Leo XIV; Pluralisms; Church and society.Cláudio De Oliveira Ribeiro

Plural; Value (mathematics); Presentation (obstetrics); Sociocultural evolution; Scarcity; Sociology; Humanities; Political science; Social science; Environmental ethics

2026-01-12https://doi.org/10.29386/reb.v85i332.6708Revista Eclesiástica Brasileira 20261P-184. Helminth co-infection in leprosy: Innocent bystander or immune dysregulator?Abstract Background Leprosy, a neglected tropical disease also called Hansen’s disease, remains a public health challenge in Brazil. Helminth infections have been shown to be associated with leprosy, but results have been mixed. We present preliminary results from a longitudinal cohort to address this question. Figure 1. Cytokine and chemokine comparisons across infection groups. Comparison of log transformed cytokine and chemokine concentrations across 4 clinical groups. Helminth infection is defined as being seropositive for either Schistosoma mansoni and Strongyloides stercoralis. LID+/ LID- signifies seropositivity for anti-LID1 antibodies. Boxes represent median (line), first and third quartiles. Outliers represented by dots. Methods Individuals ages 3 years and up (n=1315) were enrolled in eastern Minas Gerais, Brazil, and screened for anti-LID1, a Mycobacterium leprae specific antibody. Those positive without a history of leprosy and anti-LID1 negative controls were enrolled in the longitudinal study and evaluated for leprosy over time. Helminth serology (Schistosoma mansoni (SM) and Strongyloides stercoralis (SS)) by multiplexed beaded assay and stool helminth exams were performed at the onset. We then measured cytokines and chemokines from PBMC stimulated by M. leprae (ML) antigen at time 0. Results Seventy-seven (6%) individuals tested positive for anti-LID1. Of the longitudinal cohort (n = 153), 17 (11%) were seropositive for SM and 11 (7%) for SS. One individual tested positive for SM by stool. Twenty (26%) anti-LID1+ individuals were diagnosed with leprosy, half at the initial visit. Seropositivity for either SM or SS was associated with a lower likelihood of leprosy (RR = 0.83, 95% CI 0.69, 0.99) in anti-LID1+ individuals. Median concentrations of CXCL8 (p=0.07) were lower in SM-ML seropositive individuals compared to anti-LID1+ alone, and IL17, IL2, IL6 showed interesting trends in co-infection (Figure 1). Conclusion While helminths have not been associated with risk of leprosy in our cohort to date, the immune findings suggest a potential alteration of cytokine / chemokine response in co-infected (or co-seropositive) individuals. Interestingly, we found similar results with CXCL8 and IL17 in a previous study on co-infection, highlighting a potential mechanistic pathway that should be further studied. Disclosures All Authors: No reported disclosuresJessica K. Fairley; Santino Diaz-Palma; Heloine Martins Leite; Maisa Pereira Vieira; Lorena B P Oliveira; Pedro H F Marçal; Audra Bass; Marcos D S Pinheiro; Erica B M Silva; Julie A Clennon; Thomas R. Ziegler; Lance A. Waller; Jose A. G. Ferreira; Jeffrey M. Collins; Lúcia Alves Oliveira Fraga

Strongyloides stercoralis; Schistosoma mansoni; Strongyloidiasis; Leprosy; Helminths; Serology; Immune system; Cohort; Helminthiasis; Antigen; Immunology; Medicine; Chemokine; Strongyloides; Seroconversion; Schistosoma; Antibody; Hygiene hypothesis; Helminth infections; Immunoglobulin E

2026-01-01https://doi.org/10.1093/ofid/ofaf695.407Open Forum Infectious Diseases 20261Prostituição e modernização urbana: desterritorialização das trabalhadoras do sexo em Juiz de Fora nos séculos XIX-XXThe aim of this study is to analyze the deterritorialization of sex workers on Santa Rita Street in Juiz de Fora in the late 19th and early 20th centuries. A documentary and journalistic analysis was conducted using the newspaper O Pharol in order to understand the factors that led to the removal of this activity. The results indicate that this process was consolidated with Resolution No. 864 of May 1921, which prohibited the housing of “people with immoral lifestyles” in the city center. As a consequence, accompanied by repressive actions by the government and Juiz de Fora society, sex workers were displaced from Santa Rita. These women were reterritorialized in socially devalued areas located on the outskirts of the urban center. The study contributes to the understanding of the impacts of urbanization on marginalized populations, highlighting normative and social processes that reinforce spatial inequalities.Vitória Maria Hipólito Pires

Deterritorialization; Government (linguistics); Urbanization; Normative; Newspaper; Context (archaeology); Poverty; Social issues; Sociology; Gender studies; Criminology; Political science; Geography; Ethnology; Humanities; Order (exchange)

2026-01-01https://doi.org/10.5212/rlagg.v.16.i2.0003Revista Latino-americana de Geografia e Genero 20261Versificação Adversarial em Português como Operador de Jailbreak em LLMsEvidências recentes mostram que a versificação de prompts constitui um mecanismo adversarial altamente eficaz contra LLMs alinhados. O estudo “Adversarial poetry as a universal single-turn jailbreak mechanism in large language models” demonstra que instruções recusadas em prosa tornam-se executáveis quando convertidas em verso, produzindo “até 18×” mais falhas de segurança em benchmarks derivados do MLCommons AILuminate. Poemas versificados manualmente alcançam cerca de 62% de ASR, e versões automatizadas ~43%, com alguns modelos ultrapassando 90% de sucesso em turno único. O efeito é estrutural — sistemas treinados com RLHF, Constitutional AI e pipelines híbridos apresentam degradação consistente sob variações semiótico-formais mínimas. A versificação desloca o prompt para regiões latentes pouco supervisionadas, revelando guardrails excessivamente dependentes de padrões de superfície. Essa dissociação entre robustez aparente e vulnerabilidade real expõe limitações profundas dos atuais regimes de alinhamento. A ausência de avaliações em português, língua de alta complexidade morfossintática, rica tradição métrico-prosódica e mais de 250 milhões de falantes, constitui uma lacuna crítica. Protocolos experimentais devem parametrizar escansão, métrica e variação prosódica para testar vulnerabilidades específicas a padrões lusófonos, atualmente ignorados.Joao Queiroz

Adversarial system; Vulnerability (computing); Interpretation (philosophy); Work (physics); Economics; Philosophy; Humanities; Welfare economics

2026-01-13https://doi.org/10.1590/scielopreprints.14563 20261Nutritional status of patients with colostomy and ileostomy undergoing surgery due to remove colorectal cancer: a cross-sectional studyThis study aimed to compare the nutritional status of cancer patients with colostomy and ileostomy. This is a cross-sectional and descriptive study. This study was carried out in a Brazilian public health service, with 44 patients with intestinal stomas caused by colorectal cancer. Data was obtained through consultation of medical records, a food frequency questionnaire and anthropometric, nutritional and laboratory tests. Of the 44 patients, 29 underwent colostomy and 15 underwent ileostomy. Arm circumference and arm muscle circumference were significantly smaller in patients that underwent ileostomy (P= 0.004 and P= 0.050, respectively). Biochemical tests showed a similar frequency of lactose intolerance in both groups and the presence of fecal fat only in patients that underwent ileostomy (n=4; 26.7%). No differences were found between groups regarding dietary data; however, low energy and protein intake was identified. Understanding the nutritional status of patients with colostomy and ileostomy is essential to assist in research in the area, clinical, nutritional assessment, and preventing nutritional disorders.Ana Carolline Pereira da Silva; Ana Lívia de Oliveira; Ana Paula Boroni Moreira; Isabel Cristina Gonçalves Leite

Colostomy; Ileostomy; Waist; Defecation; Colorectal cancer; Lactose intolerance; Medicine; Surgery; General surgery; Internal medicine; Medical nutrition therapy; Medical record

2026-01-13https://doi.org/10.54033/cadpedv23n1-082Caderno Pedagógico 20261Reproductive efficiency of Bos indicus cows under different estradiol-free ovulation synchronization protocolsThe objective was to evaluate the fertility of Bos indicus cows submitted to an ovulation synchronization protocol without estrogen (E2). In experiment 1, injectable P4 (P4i) was administered 10 days (D-10) before the TAI protocol. On D0, cows received one intravaginal P4 device and estradiol benzoate (EB; Control) or buserelin acetate (GnRH/EC and 2GnRH). On D8, devices were removed, and all cows received eCG and PGF2α. Additionally, cows received estradiol cypionate (EC) on D8 (Control and GnRH/EC) or buserelin acetate on D10 (2GnRH). In Experiment 2, cows in the Control group underwent a protocol similar to Experiment 1. Cows in the GnRH/EC, 2GnRH/48h, and 2GnRH/54h groups were pre-synchronized with an intravaginal P4 device (D-7) and received gonadorelin and an intravaginal P4 device on D0. P4 devices were removed on D8, and all cows received eCG and PGF2α. Furthermore, the GnRH/EC group received EC, and cows in the 2GnRH/48h and 2GnRH/54h groups were administered GnRH 48 h (h) after removal of the P4 device. TAI was performed 48 (2GnRH/48h) or 54h (2GnRH/54h) after removal of the P4 device. In all experiments, the follicular diameter on D8 was greater in cows that received GnRH on D0 (P ≤ 0.01) as well as a greater ovulation rate on D0 (P ≤ 0.01). Furthermore, estrus expression was greater in cows receiving EC (P = 0.001; Exp. 2). P/AI was greater in the Control group (P = 0.001; Exp. 2). In conclusion, removal of estradiol in ovulation synchronization protocols resulted in lower fertility relative to E2-based controls.Lucas Araújo Lemos; Laís Reis Carvalho; Matheus Pedroso Vicente; L.M.S. Simões; Leonardo Silva Fernandes do Vale; José Camisão de Souza; J. N. S. Sales

Ovulation; Follicular phase; Estradiol benzoate; Buserelin; Estrous cycle; Estrus synchronization; Estrogen; Animal science; Biology; Andrology; Fertility; Reproduction; Hormone; Medicine; Endocrinology

2026-01-13https://doi.org/10.1016/j.theriogenology.2026.117830Theriogenology 20261INSTRUMENTOS DE MENSURAÇÃO DAS COMPETÊNCIAS SOCIOEMOCIONAIS: Revisão integrativa e proposta de um modelo estruturalAs competências socioemocionais são conhecidas como um construto multifatorial que pode apresentar diversas dimensões advindas de diferentes modelos teóricos. O objetivo deste estudo foi pesquisar instrumentos de competências socioemocionais publicados na literatura, para análise e proposição de um novo modelo estrutural. Para isso, foi conduzida uma revisão integrativa que buscou analisar artigos, dissertações e teses publicadas entre os anos de 2004 e 2019, nas bases de dados: Latin American and Caribbean Health Science Literature (Lilacs), Scientific Electronic Library Online (SciELO), Web of Science, Biblioteca Digital Brasileira de Teses e Dissertações e no Scholar Google. A coleta identificou 17 instrumentos em um total de 855 publicações. Foram identificados 13 instrumentos internacionais e 4 nacionais. Os resultados mais significativos demonstraram que 88% das pesquisas ocorreram no contexto educacional, sendo apenas 15% conduzidas com universitários, demonstrando a existência de uma carência de estudos com essa população. Nenhuma pesquisa conduziu uma revisão criteriosa para identificação de instrumentos existentes e apenas 6 pesquisas especificaram modelos teóricos para a construção dos fatores e seus itens. Conclui-se que, a proposta de um modelo estrutural construído neste estudo, pode contribuir fortemente com pesquisadores para o desenvolvimento de instrumentos psicométricos mais robustos.Rodrigo Rodrigues de Souza; Luiz Carlos Victorino Souza Junior; Lígia Abreu Cruz

Context (archaeology); Set (abstract data type); Data collection; Audit; Humanities; Computer science; Philosophy

2026-01-14https://doi.org/10.22289/2446-922x.v12a1a5Psicologia e Saúde em Debate 20261Erratum: Precision measurement of the $$B^0$$ meson lifetime using $$B^0 \rightarrow J/\psi K^{*0}$$ decays with the ATLAS detectorA measurement of the $B^0$ meson lifetime using $B^0 \to J/\psi K^{*0}$ decays in data from 13 TeV proton-proton collisions with an integrated luminosity of 140 fb$^{-1}$ recorded by the ATLAS detector at the LHC is presented. The measured effective lifetime is $ \tau = 1.5053 \pm 0.0012 ~\mathrm{(stat.)} \pm 0.0035 ~\mathrm{(syst.)~ps}. $ The average decay width, extracted from the effective lifetime and using a parameter from external sources, is $ \Gamma_d = 0.6643 \pm 0.0005 ~\mathrm{(stat.)} \pm 0.0016 ~\mathrm{(syst.)} \mathrm{ps}^{-1}, $ where the uncertainties are statistical and systematic. The uncertainty due to external sources is negligible at the given precision. The earlier ATLAS measurement of $\Gamma_s$ in the $B^0_s \to J/\psi\phi$ decay was used to derive a value for the ratio of the average decay widths $\Gamma_d$ and $\Gamma_s$ for $B^0$ and $B^0_s$ mesons respectively, of $ \frac{\Gamma_d}{\Gamma_s} = 0.9910 \pm 0.0022 ~\mathrm{(stat.)} \pm 0.0036 ~\mathrm{(syst.)}. $ The measured lifetime, average decay width and decay width ratio are in agreement with theoretical predictions and with measurements by other experiments. This measurement provides the most precise result of the effective lifetime of the $B^0$ meson to date.G. Aad; E. Aakvaag; B. Abbott; Sara Abdelhameed; Karin Abeling; N. J. Abicht; S. H. Abidi; Mohammed Aboelela; A. Aboulhorma; H. Abramowicz; H. Abreu; Y. Abulaiti; B. S. Acharya; Alexander Ackermann; C. Adam Bourdarios; L. Adamczyk; S. V. Addepalli; M. J. Addison; J. Adelman; A. Adiguzel; T. Adye; A. A. Affolder; Y. Afik; M. N. Agaras; J. Agarwala; A. Aggarwal; C. Agheorghiesei; F. Ahmadov; W. S. Ahmed; S. Ahuja; X. Ai; G. Aielli; A. Aikot; M. Ait Tamlihat; Brahim Aitbenchikh; M. Akbiyik; T. P. A. Åkesson; A. V. Akimov; D. Akiyama; N. N. Akolkar; S. Aktas; K. Al Khoury; G. L. Alberghi; J. Albert; P. Albicocco; G. L. Albouy; S. Alderweireldt; Z. L. Alegria; Martin Aleksa; I. N. Aleksandrov; Călin Alexa; T. Alexopoulos; F. Alfonsi; M. Algren; M. Alhroob; B. Ali; H. M. J. Ali; S. Ali; S. W. Alibocus; M. Aliev; G. Alimonti; W. Alkakhi; C. Allaire; B. M. M. Allbrooke; J. F. Allen; C. A. Allendes Flores; P. P. Allport; A. Aloisio; Fernando Martín Alonso; C. Alpigiani; Z. M. K. Alsolami; M. Alvarez Estevez; A. Alvarez Fernandez; M. Alves Cardoso; M. G. Alviggi; M. Aly; Y. Amaral Coutinho; A. Ambler; C. Amelung; M. Amerl; C. G. Ames; D. Amidei; B. Amini; K. Amirie; S. P. Amor Dos Santos; K. R. Amos; D. Amperiadou; S. An; V. Ananiev; C. Anastopoulos; T. Andeen; J. K. Anders; A. C. Anderson; S. Y. Andrean; A. Andreazza; S. Angelidakis; A. Angerami; A. V. Anisenkov; A. Annovi; C. Antel

Detector; Meson; Atlas (anatomy); Atlas detector; Large Hadron Collider; Particle identification; Physics; Particle physics; Nuclear physics

2026-01-15https://doi.org/10.1140/epjc/s10052-025-15188-5The European Physical Journal C 20261Reservatórios no limite: como modelos matemáticos podem ajudar a reduzir crises hídricasPedro Villa; Ricardo Santos Silva Amorim; Alisson Lopes Rodrigues

Context (archaeology); Term (time); Perspective (graphical); Political science

2026-01-16https://doi.org/10.64628/ade.69eyrtdff 20261Psychometric properties of an adapted working alliance scale among LatinosObjective: To assess the psychometric properties (i.e., internal consistency reliability, factorial validity, concurrent validity, and discriminant validity) of the Working Alliance with Smoking Cessation Program (WASCOP) Scale, an adapted scale of working alliance designed for "non-traditional" therapeutic settings. Methods: , a randomized clinical trial assessing the efficacy of a culturally accommodated mobile smoking cessation intervention among Latinos. The sample included 374 participants who completed at least 10 of the 12 WASCOP items. Analyses included Cronbach's alpha, exploratory factor analysis, and Spearman's correlations with study satisfaction and smoking self-efficacy. Results: = 0.91). Factor analysis supported a two-factor structure. WASCOP scores were moderately correlated with program satisfaction (r = 0.530) and weakly with self-efficacy (r = 0.318), supporting construct and discriminant validity. Conclusion: The 10-item WASCOP Scale possesses acceptable internal consistency reliability, construct validity, and concurrent validity among Latinos. These findings support it potential applications in both research and clinical settings.Francisco Cartujano-Barrera; Alessandra Fabrino Bretas Cupertino; Daimarelys Lara; Laisa Marcorela Andreoli Sartes; Jeffrey W. Ramos-Santiago; Ciara A. Torres; Dora Ponce; Delwyn Catley; Lisa Sanderson Cox; Ana Paula Cupertino

Scale (ratio); Construct validity; Internal consistency; Construct (python library); Alliance; Psychometrics; Concurrent validity; Test validity; Psychology; Applied psychology; Social psychology; Consistency (knowledge bases); Clinical psychology; Reliability (semiconductor); Developmental psychology; Predictive validity

2026-01-16https://doi.org/10.3389/fpsyg.2025.1646855Frontiers in Psychology 20261TRENS, TRILHOS E ESTAÇÕESEntre o final do século XIX e as primeiras décadas do século XX, as ferrovias eram vistas no Brasil como sinônimas do progresso e a chegada de suas estações era aguardada com grande apreensão. De fato, elas funcionaram como importantes agentes de organização dos territórios, incluindo a região que compreende o sul da Zona da Mata mineira e a parte contígua do estado do Rio de Janeiro, recorte territorial dessa pesquisa, que abrange o trecho localizado entre as estações ferroviárias de Três Rios/RJ e Mariano Procópio, em Juiz de Fora/MG. Essa região, no período destacado, caracterizava-se pela grande produção cafeeira, e a chegada dos trens implicou no seu dinamismo econômico, com grande movimentação de cargas e passageiros, especialmente nas localidades servidas por suas estações, em volta das quais se instalavam comercio, escolas, correios, ou seja, intensa dinâmica social e econômica. Não há dúvidas que a ferrovia impactou a organização territorial regional, mas a questão que buscamos responder foi outra: a ferrovia criou povoações a partir de suas estações, ou aproveitou-se da prévia existência dessas povoações para implantá-las? Os resultados apontam para uma necessária revisão de conceitos, pois como constatado, as estações ferroviárias foram implantadas em povoações já existentes, que tinham posição estratégica para o escoamento da produção do café, esse sim, o principal definidor da localização de trens, trilhos e estações.Pedro José de Oliveira Machado; Wagner Barbosa Batella; Luciano Alves Soares Caramez; Matheus de Sousa Jacinto

State (computer science); Work (physics); Period (music); Product (mathematics); Perspective (graphical); Geography; Humanities

2026-01-16https://doi.org/10.70261/er.v27i2.75075Espaço em Revista 20261Postural and cardiorespiratory responses to emotionally-laden whole-body expressionsPostural and autonomic adjustments are commonly described during the observation of emotional stimuli. Thus, this study investigated the physiological impact of emotional images viewing revealed by whole-body expressions. Body sway and cardiorespiratory signals were recorded in thirty-nine healthy young people who maintained an upright stance while observing 20 neutral, 20 happiness (positive) or 20 anger (negative) images from the Bodily Expressive Action Stimulus Test (BEAST) database. Participants rated each image considering their valence and arousal dimensions with the Self-Assessment Manikin. Additionally, emotional recognition level was rated using a three alternative-forced-choice task (happiness, anger, and neutral). A repeated-measures one-way analysis of variance (ANOVA) was used to compare the main physiological variables among emotionally-laden blocks. Valence statistically differed among blocks. The emotional recognition rate was above 70% for all blocks. There was a significant decrease in body sway area during the observation of anger whole-body expressions compared to the neutral and happiness ones. The mean power frequency in the medial-lateral axis showed a significant increase during viewing anger images compared to the neutral one. Further, there was a significant increase in the heart rate variability during observation of anger whole-body expressions compared to the happiness one. These findings revealed physiological adjustments in the observer while viewing whole-body expressions consistent with the emotional processing experience. Therefore, the observation of images depicting anger whole-body expressions led to postural and autonomic changes in agreement with defensive responses (”postural immobility”). • Impact of physiological and psychological responses during the observation of emotionally-laden whole-body expressions. • The observation of anger whole-body images cause body adjustments consistent with defensive response. • Autonomic and postural adjustments were consistent with postural immobility. • The physiological changes seem to reflect the emotional contagion experience.Mariana Rodrigues Alves; Anaelli Aparecida Nogueira‐Campos; Adriana Ribeiro de Macedo; Angela Nogueira Neves; Talita Peixoto Pinto; Fabio Vieira dos Anjos; Cláudia D. Vargas; Luís Aureliano Imbiriba

Anger; Happiness; Arousal; Cardiorespiratory fitness; Valence (chemistry); Heart rate; International Affective Picture System; Facial expression; Psychology; Audiology; Emotionality; Stimulus (psychology); Analysis of variance; Heart rate variability; Emotion recognition; Autonomic nervous system; Psychophysiology; Developmental psychology; Vigilance (psychology)

2026-01-17https://doi.org/10.1016/j.bbr.2026.116049Behavioural Brain Research 20261FERRAMENTA AUTOMATIZADA PARA MONITORAMENTO ASSISTENCIAL DE ARBOVIROSES NA ATENÇÃO PRIMÁRIA À SAÚDEResumo As arboviroses seguem como desafio relevante para a saúde pública. Na Atenção Primária à Saúde (APS), monitorar o impacto dessas doenças na demanda assistencial é essencial para organizar serviços, alocar recursos e planejar respostas oportunas. Apesar da ampla produção de indicadores epidemiológicos, persiste uma lacuna nacional na sistematização de indicadores assistenciais a partir de bases rotineiras, limitando a gestão baseada em evidências e a capacidade preditiva da rede. Nesse cenário, este estudo metodológico, inédito ou um dos primeiros no Brasil, elaborou e implantou ferramenta automatizada em Google Sheets, alimentada por dados do e-SUS APS (CSV). A lógica de cálculo utilizou série histórica de 2020 a 2025 e incluiu atendimentos e procedimentos relacionados às arboviroses, como exames, registros por CIAP-2 e CID-10 e atividades coletivas. A ferramenta aumentou a agilidade analítica, reduziu a manipulação manual e fortaleceu a capacidade da APS de detectar variações sazonais e apoiar decisões intersetoriais. Evidenciou-se potencial de replicabilidade, por exigir recursos amplamente disponíveis e permitir adaptação a outros agravos. Conclui-se que tecnologias acessíveis e de baixo custo, como a elaborada e disponível para uso, podem qualificar o monitoramento assistencial, integrar vigilância e atenção e apoiar a resolutividade da APS em diferentes contextos. Palavras-chaves Saúde Digital, Atenção Primária à Saúde, Infecções por Arbovirus, Indicadores de Gestão, Tecnologia de Baixo CustoCosme Rezende Laurindo

Extracellular vesicles; Video recording; Congenital disease; Clinical Practice; Medicine; Gynecology

2026-01-17https://doi.org/10.5281/zenodo.18284483Zenodo (CERN European Organization for Nuclear Research) 20261FERRAMENTA AUTOMATIZADA PARA MONITORAMENTO ASSISTENCIAL DE ARBOVIROSES NA ATENÇÃO PRIMÁRIA À SAÚDEResumo As arboviroses seguem como desafio relevante para a saúde pública. Na Atenção Primária à Saúde (APS), monitorar o impacto dessas doenças na demanda assistencial é essencial para organizar serviços, alocar recursos e planejar respostas oportunas. Apesar da ampla produção de indicadores epidemiológicos, persiste uma lacuna nacional na sistematização de indicadores assistenciais a partir de bases rotineiras, limitando a gestão baseada em evidências e a capacidade preditiva da rede. Nesse cenário, este estudo metodológico, inédito ou um dos primeiros no Brasil, elaborou e implantou ferramenta automatizada em Google Sheets, alimentada por dados do e-SUS APS (CSV). A lógica de cálculo utilizou série histórica de 2020 a 2025 e incluiu atendimentos e procedimentos relacionados às arboviroses, como exames, registros por CIAP-2 e CID-10 e atividades coletivas. A ferramenta aumentou a agilidade analítica, reduziu a manipulação manual e fortaleceu a capacidade da APS de detectar variações sazonais e apoiar decisões intersetoriais. Evidenciou-se potencial de replicabilidade, por exigir recursos amplamente disponíveis e permitir adaptação a outros agravos. Conclui-se que tecnologias acessíveis e de baixo custo, como a elaborada e disponível para uso, podem qualificar o monitoramento assistencial, integrar vigilância e atenção e apoiar a resolutividade da APS em diferentes contextos. Palavras-chaves Saúde Digital, Atenção Primária à Saúde, Infecções por Arbovirus, Indicadores de Gestão, Tecnologia de Baixo CustoCosme Rezende Laurindo

Extracellular vesicles; Video recording; Congenital disease; Clinical Practice; Medicine; Gynecology

2026-01-17https://doi.org/10.5281/zenodo.18284482Zenodo (CERN European Organization for Nuclear Research) 20261Acute Physiological Responses to Prolonged Sedentary Behavior: Impact on Cardiovascular Function and Muscle Activity in Young AdultsBackground: Prolonged sitting has been associated with adverse cardiovascular and neuromuscular responses; however, the temporal onset of these acute physiological changes remains unclear. This study aimed to determine the acute effects of prolonged sitting on blood flow, blood pressure, and muscle activity. Methods: A non-controlled clinical trial was conducted with 21 healthy adults (22.5 ± 1.60 years), both male and female. Participants remained seated continuously for three hours, with data collected every 20 min, including infrared thermography, blood pressure, and electromyographic activity. Skin temperature was measured using infrared thermography on the calf region of both legs, and the mean temperature was analyzed. Systolic and diastolic blood pressure were measured using an oscillometric device, and mean arterial pressure was subsequently calculated. Muscle activity was assessed through surface electromyography, using median frequency and root mean square values. Statistical analysis was performed using the Friedman test and the Durbin–Conover post hoc test, along with a subjective trend analysis of each variable over time. Results: A significant reduction was observed in both calf skin temperature and median frequency after 60 min of uninterrupted sitting (p < 0.05). Mean and systolic blood pressure exhibited an increasing trend after 160 min (p < 0.05). Conclusions: The exposure–response data from this study may contribute to the planning of future interventions aimed at refining recommendations for breaking up prolonged sitting periods.Jonas Ribeiro Gomes Silva; Antônio Ribeiro Neto; Dernival Bertoncello; Jeffer Eidi Sasaki; Moacir Marocolo; Nicolas Bueno Alves; Sheilla Tribess; Ciro José Brito; Jair Sindra Virtuoso Júnior

Sitting; Blood pressure; Diastole; Young adult; Adverse effect; Post-hoc analysis; Hemodynamics; Medicine; Cardiology; Internal medicine; Anesthesia; Photoplethysmogram; Mean arterial pressure; Statistical significance

2026-01-19https://doi.org/10.3390/jfmk11010041Journal of Functional Morphology and Kinesiology 20261Opinions, Attitudes and Beliefs Regarding Spirituality and Religiosity in the Clinical Practice of Dental Students: A Cross‐Sectional StudyOBJECTIVES: To investigate the opinions, attitudes and beliefs of dental students regarding the role of spirituality and religiosity (S/R) in clinical practice. METHODS: This cross-sectional study was conducted in a Brazilian dental school. The Brazilian-Portuguese version of the Network for Research Spirituality and Health (NERSH) questionnaire was used. Descriptive analyses were conducted to report data and logistic regression models were constructed to identify the factors associated with students' opinions, attitudes and beliefs about S/R. RESULTS: A total of 336 undergraduate dental students (response rate = 83.1%) were included, predominantly females (66.4%) and mean age of 22.2 (SD: 3.6) years. Most students identified as moderately/very spiritual (69.6%) and religious (64.9%), considered it appropriate to address S/R when a patient/relative brings them up (69%), and agreed that beliefs could greatly influence a patient's health (61%). This influence was also noted for dental conditions such as temporomandibular joint dysfunction (68.5%), periodontal disease (63.4%) and dental caries (50.4%). However, most (78.0%) had never addressed S/R during consultations and did not receive formal training (84.8%). Seven out of ten students reported barriers that discourage them from discussing S/R, including fear of offending patients, professional neutrality and subject discomfort. Generally, older students, male students, those at more advanced stages of the programme, and those with stronger S/R beliefs tended to have more positive opinions and attitudes toward the subject. CONCLUSION: Although most dental students hold positive opinions and attitudes toward S/R in clinical practice, structured training and systematic approaches remain lacking. These findings underscore the importance of non-biological factors in dentistry.Ana Paula de Almeida Nunes; Alessandra Lamas Granero Lucchetti; Rodrigo Guerra de Oliveira; Ana Júlia de Figueiredo Firmino; Oscarina da Silva Ezequiel; Giancarlo Lucchetti

Religiosity; Clinical Practice; Spirituality; Dental practice; MEDLINE; Psychology; Clinical psychology; Psychotherapist; Medical education

2026-01-18https://doi.org/10.1111/eje.70090European Journal Of Dental Education 20261Interactions between brown adipose tissue activity and exercise modality on metabolic kinetics: a crossover study in trained individualsin AERO-LBAT; p = 0.004). Carbohydrate oxidation displayed a characteristic biphasic decline but showed no significant differences between groups. In contrast, lipid oxidation peaked later and was substantially higher in the HBAT groups, with the most pronounced effect following HIIE. Protein oxidation remained minimal and consistent across all conditions. These findings demonstrate that elevated BAT activity is associated with increased exercise-induced energy expenditure and enhanced lipid utilization during the latter stages of exercise, with HIIE showing the most robust metabolic associations in individuals with high BAT activity.Dany Alexis Sobarzo Soto; Diego Ignácio Valenzuela Pérez; N. Almeida; Bianca Miarka; Armin Isael Alvarado Oyarzo; João Carlos Bouzas Marins; Manuel Sillero‐Quintana; Andréia Cristiane Carrenho Queiroz; Ciro José Brito

Lipid oxidation; Energy expenditure; Crossover study; Brown adipose tissue; Thermogenesis; Basal metabolic rate; Specific dynamic action; Aerobic exercise; Calorimetry; Adipose tissue; Internal medicine; Endocrinology; Chemistry; Basal (medicine); Exercise physiology; Animal science; Substrate (aquarium); Lipid metabolism; Medicine; White adipose tissue; Energy metabolism; Carbohydrate

2026-01-18https://doi.org/10.1016/j.jtherbio.2026.104392Journal of Thermal Biology 20261Predictive accuracy of the 8- and 12-item versions of the DASS-21 in measuring depression, anxiety and stress in Brazilian university studentsOBJECTIVES: To evaluate the predictive value of the DASS-8 and DASS-12 scales, derived from the full DASS-21, in assessing mental health among Brazilian university students, highlighting the innovation of validating ultra-brief instruments specifically designed to maintain high psychometric performance while enabling rapid, large-scale mental health screening in resource-constrained academic settings. STUDY DESIGN: Multicenter cross-sectional study. METHODS: Study carried out with students at eight public universities in Brazil. Data was collected through a self-completed online questionnaire. Symptoms of depression, anxiety, and stress were assessed using the DASS-21. The concurrent validity of the reduced versions of the DASS-12 and DASS-8 was determined using ROC curve analyses and sensitivity, specificity, and accuracy tests, using the DASS-21 as a reference standard. Regression models evaluated the invariance between sociodemographic and health factors with mental health outcomes in the DASS-21; DASS-12 and DASS-8. RESULTS: A total of 8650 study participants were evaluated, the majority were female (65.7 %) and aged between 18 and 22 (54.2 %). The DASS-21; 12 and 8 had excellent internal consistency (α and ω ≥ 0.91). ROC curve analysis yielded AUC values indicating strong predictive validity, with the DASS-12 reported 0.93, 0.91, and 0.90, while the DASS-8 showed AUCs of 0.92, 0.90, and 0.89 for depression, anxiety, and stress, respectively. Sensitivity ranged from 94 % to 97 % for depression, 84 %-94 % for anxiety, and 87 %-96 % for stress, with high specificity and accuracy across all subscales (>90 %). Factors associated with symptoms across the three subscales by DASS-21 were similar to those identified by DASS-12 and DASS-8. CONCLUSION: The DASS-8 and DASS-12 scales showed reliability and effectiveness in screening for symptoms of depression, anxiety, and stress in Brazilian university students.Luiz Menezes-Júnior; Waléria de Paula; Bruna Carolina Rafael Barbosa; Carolina Martins dos Santos Chagas; Clareci Silva Cardoso; Eulilian Dias de Freitas; Fernanda de Carvalho Vidigal; Helian Nunes de Oliveira; Luciana Neri Nobre; Luciana Saraiva da Silva; Adriana Lúcia Meireles

Reliability (semiconductor); Stress (linguistics); Anxiety; Psychometrics; Predictive validity; Validity; Clinical psychology; Psychology; Psychological stress

2026-01-19https://doi.org/10.1016/j.puhe.2026.106150Public Health 20261Editorial: Novel therapeutic targets in autoimmune diseases: intestinal microbiota and adaptive immunity regulationThe authors declare that no Generative AI was used in the creation of this manuscript. 16Any alternative text (alt text) provided alongside figures in this article has been generated by Frontiers 17 with the support of artificial intelligence and reasonable efforts have been made to ensure accuracy, 18 including review by the authors wherever possible. If you identify any issues, please contact us. 19All claims expressed in this article are solely those of the authors and do not necessarily represent those 21 of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product 22 that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed 23 or endorsed by the publisher. 24Autoimmune diseases comprise more than 80 different diseases and affect an increasing 25 number of people, with women between the ages of 20 and 40 being the most affected. Autoimmune 26 diseases are a significant burden on the healthcare system and are characterized by the presence of 27 autoreactive T lymphocytes or autoantibodies, which may be physiologically or pathologically 28 induced.Caio César de Souza Alves; Sandra Bertelli Ribeiro de Castro; Alessa Sin Singer Brugiolo

Acquired immune system; Hygiene hypothesis; Immunity; Affect (linguistics); Gut flora; Product (mathematics); Immunology; Medicine; Generative grammar; Biology; Autoimmunity

2026-01-20https://doi.org/10.3389/fimmu.2026.1779062Frontiers in Immunology 20261La Costituzione brasiliana del 1988 e i regimi politici: un profilo di storia intellettuale (1972-2019)Questo articolo formula una storia intellettuale della Costituzione brasiliana del 1988 in occasione del suo 30° anniversario, descrivendo le fratture che hanno accompagnato la sua nascita e le controversie politiche e ideologiche che hanno segnato la sua esistenza. Il testo descrive tre momenti dell’immaginario politico costituzionale. La prima riguarda la questione della natura e dei confini del potere costituente e, di conseguenza, del modello dell’Assemblea costituente in grado di porre fine al ciclo autoritario (1977-1994). Il secondo si riferisce ai dibattiti giuridici e politici che hanno avuto luogo dopo che il regime politico ha raggiunto la dimensione della routine, che ha riguardato il suo modello di governance, ovvero come i poteri politici – esecutivo, legislativo e giudiziario – dovevano relazionarsi tra loro (1994-2013). Infine, questo studio ambisce a dare una spiegazione dell’attuale crisi costituzionale (2013-2018), partendo dalla tesi contrastante dei due modelli attraverso i quali la Costituzione era stata interpretata: quello del presidenzialismo di coalizione e quello della “giudizializzazione” della politica.Christian Edward Cyril Lynch; Jorge Chaloub

Repeal; Authorization; Medieval history; Humanities; Political science

2026-01-13https://doi.org/10.63277/gsc.v40i.4448Giornale di storia costituzionale 20261Toward Cardiac Electrophysiology Digital Twins with an Efficient Open Source Scalable Solver on GPU ClustersFile description The following repository contains all the necessary files to reproduce the manuscript "Toward Cardiac Electrophysiology Digital Twins with an Efficient Open Source Scalable Solver on GPU Clusters". Among the files are the following: monoalg3d_config_files.zip = All the configuration files for the computational simulations: "Benchmark myocardium cuboid", "Purkinje-Muscle-Junction calibration" and "Large-scale biventricular simulations"; monoalg3d_purkinje_networks.zip = All the Purkinje networks and PMJ files for the "Purkinje-Muscle-Junction calibration" and "Large-scale biventricular simulations"; monoalg3d_polaris_job_files.zip = All the job files to execute the "Benchmark myocardium cuboid", "Large-scale biventricular simulations" and "Purkinje-Muscle-Junction calibration" simulations on the Polaris supercomputer; monoalg3d_source_files.zip = the custom source files to build MonoAlg3D on Polaris. This file contains the implemented custom functions for the "domains_library", "extra_data_library" and "matrix_assembly_library". In addition, the modified version of the ToR-ORd cellular model for T-wave personalisation is also provided within the "models_library" folder; monoalg3d_ventricular_meshes.zip = All the ventricular meshes in ALG format used for the "Purkinje-Muscle-Junction calibration" and "Large-scale biventricular simulations". Build and configuration MonoAlg3D is developed by Rafael Sachetto Oliveira et al., Int J Numer Method Biomed Eng (2018) (the original solver is available on GitHub at: MonoAlg3D_C). To configure the solver for this study follow the build procedures on the solver`s GitHub repository and copy the source files from monoalg3d_source_files.zip. Build the solver again with the command: ./build.sh -f Biventricular meshes The human biventricular mesh and ECG electrodes positions were derived from MRI data in Lyon et al., Front Physiol (2018) and Minchole et al., Front Physiol (2019) and can be found in https://zenodo.org/records/14046617 (referred to as Subject/Control 2 as in Camps et al., Med Image Anal (2024)). The ALG columns for the biventricular meshes have the following syntax: 54250,21250,250,250,250,250,0.000399119,1,0.249467,1,1,0.626517,-0.775963,-0.00453349,0.168679,0.130518,0.97453,0.758425,0.614972,-0.213462,7.15285928592859 54750,21250,250,250,250,250,0.0196224,1,0.245434,1,1,0.590492,-0.781949,0.0278572,0.136531,0.13876,0.979878,0.770388,0.574527,-0.192601,7.15285928592859 55250,21250,250,250,250,250,0.0190111,1,0.2414,1,1,0.587508,-0.783926,0.0437592,0.10975,0.136908,0.982621,0.776757,0.573408,-0.170214,7.15285928592859 55750,21250,250,250,250,250,0.0183998,1,0.237367,1,1,0.584524,-0.785903,0.0596612,0.0829692,0.135057,0.985363,0.783125,0.572289,-0.147828,7.3178097809781 1st Column: Coordinate x of the centre of the cell (units in micrometres); 2nd Column: Coordinate y of the centre of the cell (units in micrometres); 3rd Column: Coordinate z of the centre of the cell (units in micrometres); 4th Column: Half discretization in the x direction (units in micrometres); 5th Column: Half discretization in the y direction (units in micrometres); 6th Column: Half discretization in the z direction (units in micrometres); 7th Column: Transmurality: range=[0, 1]; 8th Column: Transmurality labels: 1-ENDO, 2-MID, 3-EPI; 9th Column: Base to apex heterogeneity: range=[0, 1]; 10th Column: Fast endocardium layer: 0=FAST ENDO, 1=NORMAL, 2=DENSE, 3=SPARSE; 11th Column: Infarct stage: 1=Healthy, 2=Borderzone, 3=Infarcted-stage1, 4=Infarcted-stage2, ... 12th-14th Columns: Fiber orientation f vector: fx, fy and fz values 15th-17th Columns: Fiber orientation s vector: sx, sy and sz values 18th-20th Columns: Fiber orientation n vector: nx, ny and nz values 21th Column: IKs scaling factor. For the "Purkinje-Muscle-Junction calibration" simulations the dense/sparse biventricular wedges were generated using the "src/main_clip_mesh.c" script by extracting a part of the biventricular mesh with a box around the specified Purkinje terminals, as depicted on Figure 2A from the main manuscript. Fibre fields were derived as in Doste et al., Int J Numer Method Biomed Eng (2019). The fast endocardium layer region was generated following Camps et al., Med Image Anal (2024). Scaling factors for the IKs current were calculated following Camps et al., Med Image Anal (2025). Purkinje network The Purkinje network and Purkinje-Muscle-Junctions were inferred in Camps et al., Med Image Anal (2024) by a minimal Purkinje network, which was later expanded by an extra branching procedure following Berg et al., Sci Rep (2023). Run and dispatch simulations To execute the simulations located in the configuration files (monoalg3d_config_files.zip), just execute: ./bin/MonoAlg3D -c <configuration_file_path> Simulations that use the MPI batch will need MPI configured and can be executed with: mpiexec --np ${NMPIPROCESS} -ppn ${NRANKS_PER_NODE} --depth=${NDEPTH} --cpu-bind depth [GPU_AFFINITY_SCRIPT] ./bin/MonoAlg3D_batch -c <batch_configuration_file> All simulations were dispatched on Polaris using the job files (monoalg3d_polaris_job_files.zip) with the command: qsub <job_file>Lucas Arantes Berg; Rafael Sachetto Oliveira; Julia Camps; Lucas Marins Ramalho de Lima; Joventino Campos; Zhinuo Jenny Wang; Rubén Doste; Alfonso Bueno‐Orovio; Rodrigo Weber dos Santos; Blanca Rodriguez

Solver; Open source; Scalability; Polygon mesh; Source code; File format; Computer science; Parallel computing; Computational science; Computer graphics (images)

2026-01-20https://doi.org/10.5281/zenodo.15041476Zenodo (CERN European Organization for Nuclear Research) 20261Toward Cardiac Electrophysiology Digital Twins with an Efficient Open Source Scalable Solver on GPU ClustersFile description The following repository contains all the necessary files to reproduce the manuscript "Toward Cardiac Electrophysiology Digital Twins with an Efficient Open Source Scalable Solver on GPU Clusters". Among the files are the following: monoalg3d_config_files.zip = All the configuration files for the computational simulations: "Benchmark myocardium cuboid", "Purkinje-Muscle-Junction calibration" and "Large-scale biventricular simulations"; monoalg3d_purkinje_networks.zip = All the Purkinje networks and PMJ files for the "Purkinje-Muscle-Junction calibration" and "Large-scale biventricular simulations"; monoalg3d_polaris_job_files.zip = All the job files to execute the "Benchmark myocardium cuboid", "Large-scale biventricular simulations" and "Purkinje-Muscle-Junction calibration" simulations on the Polaris supercomputer; monoalg3d_source_files.zip = the custom source files to build MonoAlg3D on Polaris. This file contains the implemented custom functions for the "domains_library", "extra_data_library" and "matrix_assembly_library". In addition, the modified version of the ToR-ORd cellular model for T-wave personalisation is also provided within the "models_library" folder; monoalg3d_ventricular_meshes.zip = All the ventricular meshes in ALG format used for the "Purkinje-Muscle-Junction calibration" and "Large-scale biventricular simulations". Build and configuration MonoAlg3D is developed by Rafael Sachetto Oliveira et al., Int J Numer Method Biomed Eng (2018) (the original solver is available on GitHub at: MonoAlg3D_C). To configure the solver for this study follow the build procedures on the solver`s GitHub repository and copy the source files from monoalg3d_source_files.zip. Build the solver again with the command: ./build.sh -f Biventricular meshes The human biventricular mesh and ECG electrodes positions were derived from MRI data in Lyon et al., Front Physiol (2018) and Minchole et al., Front Physiol (2019) and can be found in https://zenodo.org/records/14046617 (referred to as Subject/Control 2 as in Camps et al., Med Image Anal (2024)). The ALG columns for the biventricular meshes have the following syntax: 54250,21250,250,250,250,250,0.000399119,1,0.249467,1,1,0.626517,-0.775963,-0.00453349,0.168679,0.130518,0.97453,0.758425,0.614972,-0.213462,7.15285928592859 54750,21250,250,250,250,250,0.0196224,1,0.245434,1,1,0.590492,-0.781949,0.0278572,0.136531,0.13876,0.979878,0.770388,0.574527,-0.192601,7.15285928592859 55250,21250,250,250,250,250,0.0190111,1,0.2414,1,1,0.587508,-0.783926,0.0437592,0.10975,0.136908,0.982621,0.776757,0.573408,-0.170214,7.15285928592859 55750,21250,250,250,250,250,0.0183998,1,0.237367,1,1,0.584524,-0.785903,0.0596612,0.0829692,0.135057,0.985363,0.783125,0.572289,-0.147828,7.3178097809781 1st Column: Coordinate x of the centre of the cell (units in micrometres); 2nd Column: Coordinate y of the centre of the cell (units in micrometres); 3rd Column: Coordinate z of the centre of the cell (units in micrometres); 4th Column: Half discretization in the x direction (units in micrometres); 5th Column: Half discretization in the y direction (units in micrometres); 6th Column: Half discretization in the z direction (units in micrometres); 7th Column: Transmurality: range=[0, 1]; 8th Column: Transmurality labels: 1-ENDO, 2-MID, 3-EPI; 9th Column: Base to apex heterogeneity: range=[0, 1]; 10th Column: Fast endocardium layer: 0=FAST ENDO, 1=NORMAL, 2=DENSE, 3=SPARSE; 11th Column: Infarct stage: 1=Healthy, 2=Borderzone, 3=Infarcted-stage1, 4=Infarcted-stage2, ... 12th-14th Columns: Fiber orientation f vector: fx, fy and fz values 15th-17th Columns: Fiber orientation s vector: sx, sy and sz values 18th-20th Columns: Fiber orientation n vector: nx, ny and nz values 21th Column: IKs scaling factor. For the "Purkinje-Muscle-Junction calibration" simulations the dense/sparse biventricular wedges were generated using the "src/main_clip_mesh.c" script by extracting a part of the biventricular mesh with a box around the specified Purkinje terminals, as depicted on Figure 2A from the main manuscript. Fibre fields were derived as in Doste et al., Int J Numer Method Biomed Eng (2019). The fast endocardium layer region was generated following Camps et al., Med Image Anal (2024). Scaling factors for the IKs current were calculated following Camps et al., Med Image Anal (2025). Purkinje network The Purkinje network and Purkinje-Muscle-Junctions were inferred in Camps et al., Med Image Anal (2024) by a minimal Purkinje network, which was later expanded by an extra branching procedure following Berg et al., Sci Rep (2023). Run and dispatch simulations To execute the simulations located in the configuration files (monoalg3d_config_files.zip), just execute: ./bin/MonoAlg3D -c <configuration_file_path> Simulations that use the MPI batch will need MPI configured and can be executed with: mpiexec --np ${NMPIPROCESS} -ppn ${NRANKS_PER_NODE} --depth=${NDEPTH} --cpu-bind depth [GPU_AFFINITY_SCRIPT] ./bin/MonoAlg3D_batch -c <batch_configuration_file> All simulations were dispatched on Polaris using the job files (monoalg3d_polaris_job_files.zip) with the command: qsub <job_file>Lucas Arantes Berg; Rafael Sachetto Oliveira; Julia Camps; Lucas Marins Ramalho de Lima; Joventino Campos; Zhinuo Jenny Wang; Rubén Doste; Alfonso Bueno‐Orovio; Rodrigo Weber dos Santos; Blanca Rodriguez

Solver; Open source; Scalability; Polygon mesh; Source code; File format; Computer science; Parallel computing; Computational science; Computer graphics (images)

2026-01-20https://doi.org/10.5281/zenodo.15041475Zenodo (CERN European Organization for Nuclear Research) 20261Sensorial function in children with congenital Zika syndrome: what is the relationship with motor function?OBJECTIVE: To investigate sensory impairments in children with congenital Zika syndrome (CZS) and the relationship with motor function. METHODS: This is a cross-sectional, analytical study of medical records of children with CZS who were assisted by a support center for children with microcephaly in northeastern Brazil. General data about the children and their caregivers were recorded. Data from the Gross Motor Function Measure (GMFM-88) score and Gross Motor Function Classification System classification were recorded for motor function assessment, and the Sensory Profile 2 score was recorded for sensory function. RESULTS: A total of 32 children with a mean age of 53.4±10.8 months participated in the study. The GMFM-88 score was positively correlated with the total score of the Sensory Profile 2 (r=0.49, p=0.004) and with the scores for tactile (r=0.44, p=0.011), vestibular (r=0.41, p=0.019), and proprioceptive (r=0.35, p=0.045) systems. When adjusted for age, only children under 50 months old (n=16) presented these correlations (tactile: r=0.69, p=0.003, vestibular: r=0.74, p=0.001, and proprioceptive: r=0.63, p=0.009). CONCLUSIONS: The tactile, vestibular, and proprioceptive systems were correlated with the gross motor function in children under 50 months old with CZS. These findings suggest the clinical relevance of considering both sensory and motor domains in the evaluation and care of children with CZS, supporting the need for early and integrated sensory-motor interventions.Ana Stela Salvino de Brito; Chanazy Ayalla de Castro Meira; Karinny Michelle Alves Moreira; Thayla Amorim Santino; Jousilene de Sales Tavares; Gabriela Lopes Gama; Adriana Melo

Motor function; Sensory system; Proprioception; Gross motor skill; Motor activity; Relevance (law); Function (biology); Medicine; Physical medicine and rehabilitation; Pediatrics; Audiology; Motor skill

2026-01-01https://doi.org/10.1590/1984-0462/2026/44/2025112Revista Paulista de Pediatria 20261Entre ontoteologia e o último deus: Notas sobre a relação entre ética e religião em Martin HeideggerEste artigo pretende analisar os limites e horizontes da relação entre ética e religião a partir de M. Heidegger. Dispomo-nos a responder à seguinte problemática: de que modo a obra de Heidegger suporta as ambiguidades da relação entre ética e religião? Consideramos que há certa ambiguidade nessa relação que se demonstra de um modo na releitura da tradição e de outro na projeção das possibilidades. No primeiro caso, fundamentamo-nos no conceito de ontoteologia, enquanto, no segundo, apropriamo-nos da noção de habitar. Nossa hipótese fundamental é que tanto no pensamento da ética da tradição quanto na abertura para uma ética originária, elementos religiosos são fundamentais e, consequentemente, ambíguos. PALAVRAS-CHAVE: Martin Heidegger. Ética. Religião.Danilo Mendes

Perspective (graphical); Relation (database); Object (grammar); Subject (documents); Modernity; Interpretation (philosophy); Theme (computing); Philosophy; Epistemology; Humanities

2026-01-20https://doi.org/10.20911/21799024v16n2p70/2025Pensar-Revista Eletrônica da FAJE 20261From Rotations to Unitaries: Reversible Quantum Processes and the Emergence of the SU(2)−SO(3) HomomorphismAbstract We present an operational reconstruction of the well-known two-to-one homomorphism between the groups SU(2) and SO(3), grounded in the physical description of quantum state preparation and evolution. Starting from the connection between vectors in three-dimensional physical space and quantum states of two-level systems, we investigate how reversible transformations–modeled as completely positive and trace-preserving maps–give rise to a correspondence between spatial rotations and unitary operations. Our approach reveals how this group-theoretic structure naturally emerges from physical constraints, particularly the preservation of purity and reversibility in quantum processes. Beyond its theoretical relevance, the construction offers a pedagogically accessible framework for introducing core ideas in quantum mechanics and symmetry groups, making the abstract correspondence between SU(2) and SO(3) tangible through experimentally meaningful procedures.V.G Valle; B. F. Rizzuti

Homomorphism; Unitary state; Quantum; Space (punctuation); Quantum operation; Symmetry (geometry); Quantum process; Quantum state; Physical system; Theoretical physics; State (computer science); Core (optical fiber); Mathematics; Symmetry group; Physics; Quantum mechanics; Connection (principal bundle); Algebra over a field; Pure mathematics; Class (philosophy); Group (periodic table); Object (grammar); Quantum system

2026-01-01https://doi.org/10.1590/1806-9126-rbef-2025-0374Revista Brasileira de Ensino de Física 20261A Machine Learning Framework for the Prediction of Propeller Blade Natural FrequenciesCharacterization of propeller blade vibrations is essential to ensure aerodynamic performance, minimize noise emissions, and maintain structural integrity in aerospace and unmanned aerial vehicle applications. Conventional high-fidelity finite-element and fluid–structure simulations yield precise modal predictions but incur prohibitive computational costs, limiting rapid design exploration. This paper introduces a data-driven surrogate modeling framework based on a feedforward neural network to predict natural vibration frequencies of propeller blades with high accuracy and a dramatically reduced runtime. A dataset of 1364 airfoil geometries was parameterized, meshed, and analyzed in ANSYS 2024 R2 across a range of rotational speeds and boundary conditions to generate modal responses. A TensorFlow/Keras model was trained and optimized via randomized search cross-validation over network depth, neuron counts, learning rate, batch size, and optimizer selection. The resulting surrogate achieves R2>0.90 and NRMSE<0.08 for the second and higher-order modes, while reducing prediction time by several orders of magnitude compared to full finite-element workflows. The proposed approach seamlessly integrates with CAD/CAE pipelines and supports rapid, iterative optimization and real-time decision support in propeller design.Nícolas Lima Oliveira; Afonso Celso de Castro Lemonge; Patrícia Habib Hallak; Konstantinos Kyprianidis; Stavros Vouros

Propeller; Artificial neural network; Airfoil; Vibration; Noise (video); Surrogate model; Range (aeronautics); Aerodynamics; Modal; Computer science; Engineering; Artificial intelligence; Support vector machine; Machine learning; Feed forward; Blade element momentum theory; Modal analysis; Closing (real estate); Blade (archaeology)

2026-01-21https://doi.org/10.3390/machines14010124Machines 20261P0695 Revisiting Risankizumab vs Ustekinumab in Crohn’s Disease: A Systematic Review-Informed Bayesian Reanalysis of the SEQUENCE TrialAbstract Background In the SEQUENCE trial, risankizumab demonstrated non-inferiority to ustekinumab in clinical remission and was superior in attaining endoscopic remission by week 48. However, concerns have been raised about potential bias due to the open-label design and higher withdrawal rates in the ustekinumab arm. A Bayesian reanalysis using as-observed data and informative priors from prior randomized trials may offer a more balanced and decision-relevant estimate of comparative efficacy. This study aims to evaluate and compare the clinical and endoscopic efficacy of risankizumab and ustekinumab in moderate-to-severe Crohn’s disease through a Bayesian framework that synthesizes SEQUENCE trial data with prior evidence from randomized controlled trials. Methods We performed a systematic review of randomized controlled trials reporting clinical or endoscopic remission with risankizumab or ustekinumab in moderate-to-severe Crohn’s disease. The PubMed search (August 31, 2025) followed PRISMA 2020 guidelines and was registered in PROSPERO. Data extracted from the eligible trials were used to construct empirically derived beta priors for each treatment. A Bayesian conjugate beta-binomial model was applied to the as-observed data from the SEQUENCE trial to generate posterior distributions for clinical remission (CDAI &lt;150) and endoscopic remission (SES-CD ≤4 with no subscore &gt;1) at week 48. Sensitivity analyses were conducted using alternative prior assumptions, including non-informative and conservative priors. Results Among 1,192 identified studies, 47 were clinical trials. After detailed screening, six were selected as prior sources: FORTIFY for risankizumab, and IM-UNITI, Rutgeerts et al. (2008), GALAXI-1, GALAXI 2/3, and VIVID-1 for ustekinumab. Posterior estimates for clinical remission were 61.7% for risankizumab (95% CrI: 56.7–66.5) and 49.2% for ustekinumab (95% CrI: 45.2–53.3), with a 99.9% probability of superiority. For endoscopic remission, rates were 36.7% (95% CrI: 31.8–41.6) and 23.8% (95% CrI: 21.0–26.6), also favoring risankizumab with &gt;99.9% probability. Across all sensitivity analyses, posterior probabilities consistently exceeded 99%, and credible intervals excluded the null. Conclusion This Bayesian reanalysis reinforces the superiority of risankizumab over ustekinumab in both clinical and endoscopic remission, with posterior probabilities of superiority exceeding 99% in all models. By formally incorporating prior evidence and quantifying uncertainty, Bayesian methods enhance interpretability and support robust therapeutic decisions in Crohn’s disease. References: Ferrante M, Panaccione R, Baert F, Bossuyt P, Colombel JF, Danese S, et al. Risankizumab as maintenance therapy for moderately to severely active Crohn’s disease: results from the multicentre, randomised, double-blind, placebo-controlled, withdrawal phase 3 FORTIFY maintenance trial. Lancet. 2022 May 28;399(10343):2031–46. doi:10.1016/S0140-6736(22)00466-4. Peyrin-Biroulet L, Chapman JC, Colombel JF, Caprioli F, D’Haens G, Ferrante M, et al. Risankizumab versus Ustekinumab for Moderate-to-Severe Crohn’s Disease. N Engl J Med. 2024 Jul 18;391(3):213–23. doi:10.1056/NEJMoa2314585. Danese S, Panaccione R, Feagan BG, Afzali A, Rubin DT, Sands BE, et al. Efficacy and safety of 48 weeks of guselkumab for patients with Crohn’s disease: maintenance results from the phase 2, randomised, double-blind GALAXI-1 trial. Lancet Gastroenterol Hepatol. 2024 Feb;9(2):133–46. doi:10.1016/S2468-1253(23)00318-7. Feagan BG, Sandborn WJ, Gasink C, Jacobstein D, Lang Y, Friedman JR, et al. Ustekinumab as induction and maintenance therapy for Crohn’s disease. N Engl J Med. 2016 Nov 17;375(20):1946–60. doi:10.1056/NEJMoa1602773. Ferrante M, D’Haens G, Jairath V, Danese S, Chen M, Ghosh S, et al. Efficacy and safety of mirikizumab in patients with moderately-to-severely active Crohn’s disease: a phase 3, multicentre, randomised, double-blind, placebo-controlled and active-controlled, treat-through study. Lancet. 2024 Dec 14;404(10453):2423–36. doi:10.1016/S0140-6736(24)01762-8. Rutgeerts P, Gasink C, Chan D, Lang Y, Pollack P, Colombel JF, et al. Efficacy of ustekinumab for inducing endoscopic healing in patients with Crohn’s disease. Gastroenterology. 2018 Oct;155(4):1045–58. doi:10.1053/j.gastro.2018.06.035. Panaccione R, Feagan BG, Afzali A, Rubin DT, Reinisch W, Panés J, et al; GALAXI 2 & 3 Study Group. Efficacy and safety of intravenous induction and subcutaneous maintenance therapy with guselkumab for patients with Crohn’s disease (GALAXI-2 and GALAXI-3): 48-week results from two phase 3, randomised, placebo and active comparator-controlled, double-blind, triple-dummy trials. Lancet. 2025 Jul 26;406(10501):358–75. doi:10.1016/S0140-6736(25)00681-6. Heuts S, Kawczynski MJ, Velders BJJ, Brophy JM, Hickey GL, Kowalewski M. Statistical primer: an introduction into the principles of Bayesian statistical analyses in clinical trials. Eur J Cardiothorac Surg. 2025;67(4):ezaf139. doi:10.1093/ejcts/ezaf139. Taylor, C., Puxty, K., Quasim, T., & Shaw, M. (2025). Understanding Bayesian analysis of clinical trials: an overview for clinicians. Critical care science, 37, e20250267. https://doi.org/10.62675/2965-2774.20250267 Conflict of interest: Dr. da Silva, Bruno César: Bruno has served as Speaker for J & J and Takeda Santana, Genoile Oliveira: Honoraria - Abbvie, Johnson & Johnson, Ferring, Takeda. Research - Abivax, Takeda, Johnson & Johnson, Roche, Sanofi, Polpharma. Advisory board - Abbvie, Johnson & Johnson, MSD. da Costa, Lilia Carolina Carneiro: No conflict of interest Chebli, Julio: Speaker Janssen, Takeda, Abbott, Abbvie, PfizerB C da Silva; G O Santana; L C C da Costa; J Chebli

Ustekinumab; Randomized controlled trial; Prior probability; Clinical trial; Bayesian probability; Credible interval; Posterior probability; Medicine; Internal medicine; Bayes' theorem; Randomization; MEDLINE

2026-01-01https://doi.org/10.1093/ecco-jcc/jjaf231.876Journal of Crohn s and Colitis 20261Uma análise filosófica do agente violento contra a escolaO objetivo deste texto é contribuir com uma reflexão filosófica sobre o tema das violências contra a escola considerando particularmente um aspecto: o agente da violência e o seu dogmatismo ingênuo agudo e cáustico. A perspectiva que sustenta a argumentação deste texto parte da caracterização deste agente violento, mostrando que ele, em sua dimensão violenta, não elabora discursos de ódio, mas tão somente frases de ódio. Ao levar sua violência para a escola, além de todo o horror que ele provoca, uma de suas expectativas é transferir para o domus da escola os mesmos elementos e objetos presentes no domus da violência. Finalmente, proponho que o enfrentamento do dogmatismo ingênuo agudo e cáustico seja realizado criando experiências baseadas em uma racionalidade argumentativa cooperativa e também em experiências negativas intelectuais, que apoiem professoras e professores nos diálogos, de fato, democráticos, considerando como valores que sustentam esses diálogos o respeito, a cooperação, a incerteza, engenhada pelo incentivo de uma inquietação existencial e pelo valor do dizer, este último como fundamento da Pedagogia da Dizibilidade. Palavras-chave: Discurso; Escola; Filosofia; Pedagogia da Dizibilidade; Violência. A philosophical analysis of the violent agent against school Abstract: The objective of this text is to contribute to a philosophical reflection on the topic of violence against schools, particularly considering one aspect: the agent of violence and his acute and caustic naive dogmatism. The perspective that supports the arguments of this text is based on the characterization of this violent agent, showing that he, in his violent dimension, does not create hate speeches, but only hateful phrases. When taking his violence to school, in addition to all the horror it causes, one of his expectations is to transfer the same elements and objects present in the domus of violence to the school domus. Finally, I propose that the confrontation of acute and caustic naive dogmatism be carried out by creating experiences based on a cooperative argumentative rationality and also on negative intellectual experiences, which support teachers in dialogues, in fact, democratic, considering as values that sustain these dialogues the respect, cooperation, uncertainty, engendered by the encouragement of existential restlessness and the value of saying, the latter as the foundation of the Pedagogy of Sayability. Keywords: Speech; School; Philosophy; Pedagogy of Sayability; Violence. Une analyse philosophique de l’agent violent contre l’école Résumé: L’objectif de ce texte est de contribuer à une réflexion philosophique sur le thème de la violence à l’école, en considérant notamment un aspect: l’agent de la violence et son dogmatisme naïf aigu et caustique. La perspective qui soutient les arguments de ce texte repose sur la caractérisation de cet agent violent, montrant que lui, dans sa dimension violente, ne crée pas de discours de haine, mais seulement des phrases haineuses. Lorsqu’il transporte sa violence à l’école, outre toute l’horreur qu’elle provoque, une de ses attentes est de transférer les mêmes éléments et objets présents dans la domus de la violence à la domus de l’école. Enfin, je propose que la confrontation du dogmatisme naïf aigu et caustique se fasse en créant des expériences basées sur une rationalité argumentative coopérative et aussi sur des expériences intellectuelles négatives, qui soutiennent les enseignants dans des dialogues, en fait démocratiques, considérant comme des valeurs qui soutiennent ces dialogues le respect, la coopération, l’incertitude, engendrés par l’encouragement de l’inquiétude existentielle et la valeur du dire, cette dernière comme fondement de la Pédagogie de la Dicibilité. Mots clés: Discours; École; Philosophie; Pédagogie de la Dicibilité; Violence. Data de registro: 10/01/2025 Data de aceite: 24/09/2025Rita Pimenta

Perspective (graphical); Value (mathematics); Meaning (existential); Relation (database); Feeling; Argument (complex analysis); Politics; Context (archaeology); Philosophy; Humanities; Epistemology; Reflection (computer programming); Sociology; Psychology

2026-01-22https://doi.org/10.14393/revedfil.v39a2025-76601EDUCAÇÃO E FILOSOFIA 20261Additional file 1 of The relationship between executive functions and mathematics: a systematic review with meta-analysis of longitudinal studiesSupplementary Material 1Pedro Paulo Marci Tette; Cláudia Nascimento Guaraldo Justi; Francis Ricardo dos Reis Justi

Executive summary; Systematic review; Set (abstract data type); Longitudinal data; Interpretation (philosophy); Psychology; Cognitive psychology; Computer science

2026-01-01https://doi.org/10.6084/m9.figshare.31120924.v1Figshare 20261The relationship between executive functions and mathematics: a systematic review with meta-analysis of longitudinal studiesAbstract Objective This study examined the relationship between executive functions (EF) and mathematical skills throughout development using a meta-analysis of longitudinal studies. Method This study included (a) longitudinal studies that (b) reported correlations between EF measures (assessed at Time 1) and mathematics outcomes (assessed at Time 2) in (c) typically developing samples ranging in age from birth to 18 years. Studies were excluded if they were (a) not written in English or Portuguese, (b) aggregated data from typical and atypical populations, or (c) combined data from children and adolescents without distinction. A systematic search was conducted in October 2021 and later updated in 2025 using PsycINFO, SciELO, and PubMed. The risk of publication bias was assessed using funnel plot analysis and Egger’s test. A random-effects meta-analysis was performed. Results Twenty-nine studies involving children and adolescents (n = 104,295; M_age at Time 1 = 5.4 years; M_age at Time 2 = 8.4 years) were included. The overall correlation between EF and mathematics was moderate and statistically significant (r = 0.30, 95% CI [0.24, 0.36]). Among EF components, working memory showed the strongest association with mathematical performance (r = 0.43, 95% CI [0.35, 0.50]), followed by cognitive flexibility (r = 0.34, 95% CI [0.27, 0.42]) and inhibitory control (r = 0.21, 95% CI [0.13, 0.29]). Age and study quality did not significantly moderate the relationship between EF and mathematics. Conclusion The findings suggest that EF, particularly working memory, is a meaningful predictor of mathematical performance across development. These results underscore the importance of early EF assessment in informing interventions designed to prevent math learning difficulties. Despite the low risk of publication bias, the high heterogeneity observed in most analyses suggests the influence of additional moderating variables that warrant further investigation.Pedro Paulo Marci Tette; Cláudia Nascimento Guaraldo Justi; Francis Ricardo dos Reis Justi

Working memory; Funnel plot; Longitudinal study; Executive functions; Cognitive flexibility; Cognition; Longitudinal data; Correlation; Psychology; Developmental psychology; Flexibility (engineering); Meta-analysis; Inhibitory control; Association (psychology); Typically developing; Clinical psychology

2026-01-01https://doi.org/10.6084/m9.figshare.c.8254483.v1Figshare 20261Additional file 2 of The relationship between executive functions and mathematics: a systematic review with meta-analysis of longitudinal studiesSupplementary Material 2Pedro Paulo Marci Tette; Cláudia Nascimento Guaraldo Justi; Francis Ricardo dos Reis Justi

Executive summary; Systematic review; Set (abstract data type); Longitudinal data; Interpretation (philosophy); Psychology; Cognitive psychology; Computer science

2026-01-01https://doi.org/10.6084/m9.figshare.31120927.v1Figshare 20261The relationship between executive functions and mathematics: a systematic review with meta-analysis of longitudinal studiesOBJECTIVE: This study examined the relationship between executive functions (EF) and mathematical skills throughout development using a meta-analysis of longitudinal studies. METHOD: This study included (a) longitudinal studies that (b) reported correlations between EF measures (assessed at Time 1) and mathematics outcomes (assessed at Time 2) in (c) typically developing samples ranging in age from birth to 18 years. Studies were excluded if they were (a) not written in English or Portuguese, (b) aggregated data from typical and atypical populations, or (c) combined data from children and adolescents without distinction. A systematic search was conducted in October 2021 and later updated in 2025 using PsycINFO, SciELO, and PubMed. The risk of publication bias was assessed using funnel plot analysis and Egger's test. A random-effects meta-analysis was performed. RESULTS: Twenty-nine studies involving children and adolescents (n = 104,295; M_age at Time 1 = 5.4 years; M_age at Time 2 = 8.4 years) were included. The overall correlation between EF and mathematics was moderate and statistically significant (r = 0.30, 95% CI [0.24, 0.36]). Among EF components, working memory showed the strongest association with mathematical performance (r = 0.43, 95% CI [0.35, 0.50]), followed by cognitive flexibility (r = 0.34, 95% CI [0.27, 0.42]) and inhibitory control (r = 0.21, 95% CI [0.13, 0.29]). Age and study quality did not significantly moderate the relationship between EF and mathematics. CONCLUSION: The findings suggest that EF, particularly working memory, is a meaningful predictor of mathematical performance across development. These results underscore the importance of early EF assessment in informing interventions designed to prevent math learning difficulties. Despite the low risk of publication bias, the high heterogeneity observed in most analyses suggests the influence of additional moderating variables that warrant further investigation.Pedro Paulo Marci Tette; Cláudia Nascimento Guaraldo Justi; Francis Ricardo dos Reis Justi

Warrant; Psychological intervention; Executive functions; Moderation; Longitudinal study; Systematic review; Psychology; Cognitive psychology; Developmental psychology; Applied psychology; Cognition

2026-01-22https://doi.org/10.1186/s41155-025-00362-1Psicologia Reflexão e Crítica 20261Genetic polymorphisms in headache attributed to temporomandibular disorder: A case-control studyThe aim of this study was to examine the relationship between three single nucleotide polymorphisms (SNPs): -308 G/A TNF-α , -174 G/C IL-6 , and C677T MTHFR and the presence of headache attributed to temporomandibular disorder (HATMD). This case-control study included a total of 68 patients with HATMD and 200 controls, aged 18 years and older. Both sets of participants included both genders. The diagnosis followed the diagnostic criteria for temporomandibular disorders (DC/TMD). The temporomandibular disorder pain screen was also applied. The -308 G/A TNF-α and 677 C/T MTHFR SNPs were genotyped using polymerase chain reaction-restriction fragment polymorphism (PCR-RFLP), and -174 G/C IL-6 SNP was performed by PCR. Allele frequencies and logistic regression analysis were used to assess the association between HATMD and genotypes. The results revealed that the AA genotype of -308 G/A TNF-α SNP (OR GG/AA = 0.20, 95% CI: 0.0568-0.7724,p=0.0290) and the CT genotype of C677T MTHFR SNP (OR CC/CT = 0.40, 95% CI: 0.2224-0.7350, p= 0.0042) were protective factors for HATMD risk. No significant association was found between -174G/C IL-6 SNP and the risk of HATMD (OR GG/CC = 0.58, 95% CI: 0.2122-1.6367, p= 0.45). The -308 G/A TNF-α and C677T MTHFR SNPs were identified as protective factors against the development of HATMD. • The -308 G/A TNF-α polymorphism showed a protective effect against HATMD. • The -174G/C IL- 6 polymorphism was not associated with HATMD. • Patients with the C677T MTHFR polymorphism are less likely to have HATMD.C. Campello; Cleidiel Aparecido Araújo Lemos; Elker Lene Santos de Lima; Renata Silva Melo Fernandes; Maria Tereza Cartaxo Muniz

Single-nucleotide polymorphism; Methylenetetrahydrofolate reductase; Genotype; SNP; Polymorphism (computer science); Medicine; Genetics; Bioinformatics; Internal medicine; Genetic variants

2026-01-22https://doi.org/10.1016/j.archoralbio.2026.106523Archives of Oral Biology 20261Additional file 2 of The relationship between executive functions and mathematics: a systematic review with meta-analysis of longitudinal studiesSupplementary Material 2Pedro Paulo Marci Tette; Cláudia Nascimento Guaraldo Justi; Francis Ricardo dos Reis Justi

Executive summary; Systematic review; Set (abstract data type); Longitudinal data; Interpretation (philosophy); Psychology; Cognitive psychology; Computer science

2026-01-01https://doi.org/10.6084/m9.figshare.31120927Figshare 20261Política de inclusão regional: proposta para formulação e implementação em uma Universidade Federal no Vale do Rio DoceEste relatório técnico propõe a criação de uma política de inclusão regional para a UFJF em Governador Valadares, visando combater a alta evasão e o baixo preenchimento de vagas em cursos menos concorridos. A autora realiza um diagnóstico detalhado do perfil dos estudantes e das causas da ociosidade acadêmica, sugerindo que a instituição adote critérios de bonificação regional para democratizar o acesso local. A proposta inclui um plano de ação estruturado em sete etapas, utilizando ferramentas de gestão como o 5W2H e o Gráfico de Gantt para orientar a implementação. O objetivo final é fortalecer o papel da universidade no desenvolvimento socioeconômico do Vale do Rio Doce, garantindo a fixação de profissionais qualificados na região.Franciele Ambrósio Dias; Nathalia Carvalho Moreira

Gantt chart; Context (archaeology); Line drawings; Humanities

2026-01-22https://doi.org/10.5281/zenodo.18342044Zenodo (CERN European Organization for Nuclear Research) 20261Política de inclusão regional: proposta para formulação e implementação em uma Universidade Federal no Vale do Rio DoceEste relatório técnico propõe a criação de uma política de inclusão regional para a UFJF em Governador Valadares, visando combater a alta evasão e o baixo preenchimento de vagas em cursos menos concorridos. A autora realiza um diagnóstico detalhado do perfil dos estudantes e das causas da ociosidade acadêmica, sugerindo que a instituição adote critérios de bonificação regional para democratizar o acesso local. A proposta inclui um plano de ação estruturado em sete etapas, utilizando ferramentas de gestão como o 5W2H e o Gráfico de Gantt para orientar a implementação. O objetivo final é fortalecer o papel da universidade no desenvolvimento socioeconômico do Vale do Rio Doce, garantindo a fixação de profissionais qualificados na região.Franciele Ambrósio Dias; Nathalia Carvalho Moreira

Gantt chart; Context (archaeology); Line drawings; Humanities

2026-01-22https://doi.org/10.5281/zenodo.18342043Zenodo (CERN European Organization for Nuclear Research) 20261The relationship between executive functions and mathematics: a systematic review with meta-analysis of longitudinal studiesAbstract Objective This study examined the relationship between executive functions (EF) and mathematical skills throughout development using a meta-analysis of longitudinal studies. Method This study included (a) longitudinal studies that (b) reported correlations between EF measures (assessed at Time 1) and mathematics outcomes (assessed at Time 2) in (c) typically developing samples ranging in age from birth to 18 years. Studies were excluded if they were (a) not written in English or Portuguese, (b) aggregated data from typical and atypical populations, or (c) combined data from children and adolescents without distinction. A systematic search was conducted in October 2021 and later updated in 2025 using PsycINFO, SciELO, and PubMed. The risk of publication bias was assessed using funnel plot analysis and Egger’s test. A random-effects meta-analysis was performed. Results Twenty-nine studies involving children and adolescents (n = 104,295; M_age at Time 1 = 5.4 years; M_age at Time 2 = 8.4 years) were included. The overall correlation between EF and mathematics was moderate and statistically significant (r = 0.30, 95% CI [0.24, 0.36]). Among EF components, working memory showed the strongest association with mathematical performance (r = 0.43, 95% CI [0.35, 0.50]), followed by cognitive flexibility (r = 0.34, 95% CI [0.27, 0.42]) and inhibitory control (r = 0.21, 95% CI [0.13, 0.29]). Age and study quality did not significantly moderate the relationship between EF and mathematics. Conclusion The findings suggest that EF, particularly working memory, is a meaningful predictor of mathematical performance across development. These results underscore the importance of early EF assessment in informing interventions designed to prevent math learning difficulties. Despite the low risk of publication bias, the high heterogeneity observed in most analyses suggests the influence of additional moderating variables that warrant further investigation.Pedro Paulo Marci Tette; Cláudia Nascimento Guaraldo Justi; Francis Ricardo dos Reis Justi

2026-01-01https://doi.org/10.6084/m9.figshare.c.8254483Figshare 20261Additional file 1 of The relationship between executive functions and mathematics: a systematic review with meta-analysis of longitudinal studiesSupplementary Material 1Pedro Paulo Marci Tette; Cláudia Nascimento Guaraldo Justi; Francis Ricardo dos Reis Justi

Executive summary; Systematic review; Set (abstract data type); Longitudinal data; Interpretation (philosophy); Psychology; Cognitive psychology; Computer science

2026-01-01https://doi.org/10.6084/m9.figshare.31120924Figshare 20261Immunological and metabolic importance of palliative medicine in nutritional therapy: a systematic reviewIntroduction: In the palliative care (PC) setting, levels of nutritional knowledge, emotional support, and the impact and severity of the disease can influence important immunological and metabolic responses in patients. Furthermore, the spiritual and religious (S/R) impact associated with an adequate diet for energy homeostasis is evident. Objective: To describe, through a systematic review, the immunological and metabolic importance of palliative medicine in nutritional therapy. Methods: The systematic review guidelines of the PRISMA Platform were followed. The search was conducted from June to August 2025 in the Scopus, Embase, PubMed, Science Direct, Scielo, and Google Scholar databases. Study quality was based on the GRADE instrument, and risk of bias was analyzed according to the Cochrane tool. Results and Conclusion: A total of 91 articles were found. A total of 24 articles were fully evaluated, and 14 were included and developed in this systematic review study. Using the Cochrane risk-of-bias tool, the overall assessment revealed six studies with a high risk of bias and 29 studies that did not meet the GRADE and AMSTAR-2 criteria. Most studies presented homogeneous results, with X2=73.7%>50%. The conclusion is that there is still a shortage of clinical trials on home-based PC for geriatric cancer patients, resulting in poor information and a lack of evidence. Home-based interventions appear feasible and have a positive effect on pain control and functional status, but more high-quality studies are needed. Spiritual care may be particularly important during times of illness, suffering, or near the end of life, when patients seek comfort. Patients in PC are complex, with multiple clinical, psychological, social, and spiritual problems. Using a multidisciplinary approach, especially appropriate nutritional therapy, can improve the quality of life of patients and their families. It is essential to train, expand, and integrate PC teams, allowing patients a better quality of life until their death.Glauce Lippi de Oliveira; Isabele Helaine Rabelo Dias; Francisco Alfredo Sampaio Cruz; Cristiano Villanova Andrade; Fernanda Assis Vianello Alvim; Pablo Wanglon Richter; Cristina Moraes Osório Leite; Leonardo Vieira Lima; Vaneska Carvalho Bezerra de Brito; F Durante

Systematic review; Economic shortage; Psychological intervention; Disease; Homogeneous; Palliative care; MEDLINE; Medicine; Intensive care medicine; Alternative medicine; Cancer; Cochrane collaboration; Clinical trial

2026-01-22https://doi.org/10.54448/ijn26103International Journal of Nutrology 20261Madame Bovary: histeria, feminilidade e desejo entre Flaubert e FreudEste ensaio analisa características comportamentais de Emma Bovary, protagonista da obra Madame Bovary (1857), de Gustave Flaubert, a partir da metapsicologia freudiana, com o objetivo de interpretar Emma Bovary como figura paradigmática da histeria feminina burguesa do século XIX e de discutir como seus impasses subjetivos condensam tensões entre desejo, feminilidade e crítica social. A pesquisa adota abordagem qualitativa, descritivo‑analítica, tomando o romance como corpus principal e articulando-o a conceitos formulados por Freud em seus estudos sobre a histeria, sobre a feminilidade e sobre a teoria da sexualidade. A análise organiza-se em torno de aspectos que evidenciam a insatisfação conjugal, os devaneios idealizantes, os adultérios, os sintomas corporais e o suicídio de Emma, interpretando-os à luz do desejo inconsciente, da castração e da estrutura histérica. Mostra-se que a personagem encena, simultaneamente, um protesto contra o destino feminino burguês e uma busca impossível por compensação fálica no amor, na maternidade e no consumo. Conclui-se que a leitura freudiana enriquece a compreensão do romance ao evidenciar seu diálogo com formas históricas de opressão de gênero, sugerindo desdobramentos tanto para a crítica literária quanto para a reflexão psicanalítica sobre a feminilidade e o mal‑estar diante de uma sociedade discriminatória.Avanúzia Ferreira Matias; Carla Poennia Gadelha Soares; Janicleide Vidal Maia; Ravena Régia de Sousa Barbosa; Wilson Rocha Rodrigues; Lúcia Santos; Victor Franklin Matias Silva; Denise Cristina de Souza Ribeiro; Ticiane de Fatima Lacerda Dantas; Herberto Araújo Souza

Romance; Order (exchange); Love and hate; Character (mathematics); Philosophy; Humanities; Art; Psychoanalysis

2026-01-22https://doi.org/10.52641/cadcajv11i1.1671Cadernos Cajuína 20261More than a Thickener: Xanthan Gum as a Vehicle for the Herbicidal Extract of Saussurea lappa and Its Rheological CharacterizationThe increasing demand for food is the driving force behind the search for novel, more selective, and less hazardous agrochemicals. Natural products are gaining prominence recently due to the promise of being green agrochemicals, but many natural products are poorly soluble in water, which reduces their applicability. In this work, we successfully formulated a water-insoluble Saussurea lappa root extract into a stable aqueous suspension using xanthan gum. The colloidal suspension was characterized by rheology, dynamic light scattering, and zeta potential. The results demonstrated that the suspension is a stable, sprayable, shear-thinning viscoelastic system (weak gel). A series of S. lappa solutions with xanthan gum were prepared and tested against five plant species, observing the inhibitory effect on the shoots and roots. The results were also compared with the commercial herbicide Dual. The S. lappa extract presented results comparable to or even greater than Dual for Lactuca sativa, Cucumis sativus, Brachiaria decumbens, and Bidens pilosa. However, it showed low inhibitory activity for Sorghum bicolor, highlighting its potential for selective weed control. This work illustrates xanthan gum as an effective vehicle for formulating insoluble natural products and demonstrates that S. lappa extract is a promising candidate for developing novel herbicides.Shafiu Mustapha; Bryan N. S. Pinto; Ângelo M. L. Denadai; Elson S. Alvarenga

Xanthan gum; Rheology; Zeta potential; Suspension (topology); Aqueous suspension; Colloid; Chemistry; Food science; Chromatography; Viscoelasticity; Raw material; Polysaccharide

2026-01-22https://doi.org/10.3390/plants15020337Plants 20261Brazilian Society of Rheumatology – 2025 recommendations on vaccination in immune-mediated rheumatic diseasesBACKGROUND: Patients with immune-mediated rheumatic diseases (IMRD) are at increased risk for infections due to both disease-related immune dysregulation and immunosuppressive therapy. Despite the benefits of vaccination, immunization rates in this population remain suboptimal, often due to concerns about safety, efficacy, and their potential for inducing disease flare. Regional-specific guidelines are necessary to address the particular epidemiological issues and aspects of the healthcare systems, especially in countries like Brazil. OBJECTIVE: To provide updated, evidence-based, and nationally relevant recommendations on vaccination in adult patients with IMRD in Brazil, focusing on immunogenicity, safety and disease activity outcomes. METHODS: A multidisciplinary task force from the Brazilian Society of Rheumatology conducted a systematic review and meta-analysis of studies addressing eleven clinical questions related to vaccine safety and efficacy in IMRD. Studies were selected using predefined PICO criteria. Risk of bias was assessed using JBI tools, and the certainty of evidence was evaluated with the GRADE approach. Statements were developed and submitted to a Delphi-based voting process; consensus was achieved if ≥80% of the panelists voted “agree” or “strongly agree” for all the statements. RESULTS: Eleven recommendations were developed based on a systematic review of the literature, with meta-analyses conducted when appropriate. Inactivated vaccines demonstrated a favorable safety profile, with low flare rates and no significant increase in disease activity, even under immunosuppression. Live attenuated vaccines, including yellow fever, were considered safe when administered according to timing protocols. Immunogenicity may be reduced in patients receiving methotrexate, mycophenolate, corticosteroids, rituximab, and JAK inhibitors, although this does not appear to compromise clinical protection in most cases. Temporary treatment interruption was associated with improved immunogenicity in selected contexts, but without consistent evidence of clinical benefit and with potential risks related to disease control. Specific guidance was provided for influenza and hepatitis B vaccination, as well as for prioritizing vaccination before initiating immunosuppression whenever feasible. Statements also addressed the approach to revaccination and post-vaccination serologic testing. Despite the overall very low to moderate certainty of evidence, most recommendations reached strong consensus (≥80% agreement). Shared decision-making and individualized strategies were emphasized across all scenarios. CONCLUSION: These recommendations offer tailored guidance for improving vaccination strategies in IMRD patients in Brazil. Given the heterogeneity of evidence, clinical decisions should be individualized, considering disease activity, treatment regimen, vaccine availability, and patient preferences. Shared decision-making is essential in all scenarios to enhance vaccine uptake and align preventive care with patient-centered management.Gecilmara Salviato Pileggi; Vítor Alves Cruz; Ana Cristina de Medeiros-Ribeiro; Ana Karla Guedes de Melo; André Gustavo Cunha Trolese; Anna Carolina Faria Moreira Gomes Tavares; Cristiano Augusto de Freitas Zerbini; Erika Biegelmeyer; Flávia Maria Matos Melo Campos Peixoto; Gilda Aparecida Ferreira; Joana Starling de Carvalho; Ketty Lysie Libardi Lira Machado; Lílian David de Azevedo Valadares; Marcelo de Medeiros Pinheiro; NATALIA SARZI SARTORI; Priscila Dias Cardoso Ribeiro; Rejane Maria Rodrigues de Abreu Vieira; Ricardo Machado Xavier; Sandra Lúcia Euzébio Ribeiro; Vanessa de Oliveira Magalhães; Viviane Angelina de Souza

Vaccination; Systematic review; Population; Epidemiology; Disease; Immunization; Rheumatology; Health care; Medicine; Family medicine; Intensive care medicine; Public health; MEDLINE; Herd immunity; Immunology; Immunogenicity; Meta-analysis; Alternative medicine; Clinical trial

2026-01-23https://doi.org/10.1186/s42358-026-00520-8Revista Brasileira de Reumatologia 20261Major clinical outcomes of dietary therapy in patients with lipedema in the preoperative period of plastic surgery: a systematic reviewIntroduction: The first clinical study on dietary therapy in lipedema showed improvement in general body composition and in specifically affected areas (upper and lower limbs) with the consumption of a low-carbohydrate diet and foods high in antioxidants inspired by the Mediterranean diet. Objective: It was to explore the main directions of dietary therapy in patients with lipedema as a pre-operative management tool for plastic surgery. Methods: The PRISMA Platform systematic review rules were followed. The research was carried out from August to September 2025 in the Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: A total of 127 articles were found, and 33 articles were evaluated in full, and 23 were included and developed in the present systematic review study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 15 studies with a high risk of bias and 29 studies that did not meet GRADE and AMSTAR-2. Most studies showed homogeneity in their results, with X2=71.5%>50%. It was concluded that in the pre-operative phase of plastic surgery for lipedema, the ketogenic diet effectively induced weight loss and fat mass, including in the limbs, areas considered unresponsive to dietary therapy in patients with lipedema. The best results were obtained with the combination of the ketogenic diet and carboxytherapy, which showed both an improvement in body composition and a reduction in pain, as well as an improvement in sleep quality. Healthy eating patterns for lipedema can be whole foods, enzyme-rich, plant-based, or ketogenic. Research favors plant-based low-carb diets, which correlate with decreased all-cause mortality relative to animal-based diets. Furthermore, vitamin D levels must be monitored and normalized in people with lipedema. A low-calorie diet based on foods rich in anti-inflammatory and antioxidant nutrients could contribute to the well-being of patients with lipedema, improving quality of life, and reducing asthenia, pain, and anxiety. Selenium can reduce oxidative stress, which plays an important role in lipedema. MicroRNAs produced by the stromal vascular fraction of lipedema represent important therapeutic targets for the treatment of lipedema. Precision nutrition is an emerging branch of nutrition science that aims to use omics technologies (metabolomics) to better target the nutritional treatment of lipedema.Isabele Helaine Rabelo Dias; Glauce Lippi de Oliveira; Francisco Alfredo Sampaio Cruz; Cristiano Villanova Andrade; Fernanda Assis Vianello Alvim; Pablo Wanglon Richter; Cristina Moraes Osório Leite; Leonardo Vieira Lima; Vaneska Carvalho Bezerra de Brito; F Durante

Ketogenic diet; Dietary therapy; Weight loss; Cochrane Library; Mediterranean diet; Systematic review; Dietary management; Meta-analysis; Medicine; Surgery; Internal medicine; Pediatrics; Medical nutrition therapy; MEDLINE; Physical therapy

2026-01-22https://doi.org/10.54448/mdnt26102MedNEXT Journal of Medical and Health Sciences 20261Incidents and Adverse Events Associated With Peripherally Inserted Central Catheters in NeonatologyBACKGROUND AND AIM: Peripherally inserted central catheters (PICCs) are essential in neonatal intensive care units for prolonged venous access. Despite their benefits, PICCs are associated with multiple complications. This scoping review mapped incidents and adverse events related to PICC use in neonates. METHODS AND MATERIALS: The protocol was registered on the Open Science Framework (DOI: 10.17605/OSF.IO/HKU4C). The review followed the Joanna Briggs Institute methodology and PRISMA-ScR guidelines. Searches were conducted in PubMed, EMBASE, Scopus, LILACS, BDENF, WPRO, Cochrane Library, Google Scholar, and OATD, including gray literature and reference lists. Eligibility criteria were defined using the PCC (Population, Concept, Context) framework. Two independent reviewers screened and selected studies. RESULTS: From 569 records, 24 studies met the criteria. Thirty-four types of incidents and adverse events were identified, most frequently catheter occlusion, bloodstream infection, mechanical damage, displacement, phlebitis, thrombosis, and accidental removal. The included studies varied by country, design, and sample size, with a predominance of retrospective and descriptive approaches. CONCLUSION: Peripherally inserted central catheter use in neonates carries risks that require systematic monitoring and preventive strategies. The evidence mapping highlights the need for standardized protocols and interdisciplinary training to strengthen neonatal patient safety.L. A. R. Silva; Fabio da Costa Carbogim; Herica Silva Dutra; Delma Conceição Soares da Silva; Aires Garcia dos Santos; Álvaro Francisco Lopes de Sousa; Andre Luiz Silva Alvim

Peripherally inserted central catheter; Neonatology; Adverse effect; Catheter; Adverse drug event; Medicine; Intensive care medicine; Emergency medicine; Medical emergency; MEDLINE

2026-01-23https://doi.org/10.1097/jpn.0000000000000980The Journal of Perinatal & Neonatal Nursing 20261Single and combined exposures to glyphosate and 2,4-D herbicides: impacts on membrane integrity, cell-cycle dynamics, and nucleolar activity in Allium cepaThis study aimed to examine the cytogenotoxic effects of attributed to exposure to herbicides glyphosate and 2,4-D, applied individually and in combination, on root meristematic cells of Allium cepa. The tested concentrations (0.1, 1, 10, 100, or 1000 μg/L) represent environmentally realistic levels frequently detected in freshwaters. Mixtures contained equimolar concentrations of each herbicide: M-1 (0.1 + 0.1), M-2 (1 + 1), M-3 (10 + 10), M-4 (100 + 100), and M-5 (1000 + 1000). Cell viability, mitotic index, chromosomal abnormalities, and micronuclei frequencies, as well as the number of nucleoli per nucleus were determined, together with cytotoxic parameters analyzed by flow cytometry. When applied individually, both herbicides exhibited cyto- and/or genotoxic activity. The mixtures reduced cell viability and induced cytotoxic and genotoxic responses, including mutagenic effects in M-1, M-3, and M-4. Nucleolar alterations, cell cycle delays, and cell death occurred with all treatments. Most mixture responses were equal to or greater than those of the individual herbicides. Data demonstrated that, even at environmentally relevant concentrations, combined exposure to glyphosate and 2,4-D intensified cytogenotoxic effects, reinforcing the importance of the need to consider mixture toxicity in environmental risk assessments.Gabriele Bitencourt Tavares; José Marcello Salabert de Campos; Tatiana da Silva Souza

Micronucleus test; Nucleolus; Glyphosate; Cell cycle; Toxicity; Mitosis; Genotoxicity; Cytotoxic T cell; Mitotic index; Cell; Chemistry; Membrane; Flow cytometry; Meristem; Micronucleus; Cytotoxicity; Biology; Plant cell; Cell membrane; Viability assay; Ecotoxicology; Binucleated cells; Cell growth; DNA damage; Toxicology; Biochemistry; Cell biology; Cell division

2026-01-24https://doi.org/10.1080/15287394.2026.2619858Journal of Toxicology and Environmental Health 20261Remimazolam compared with propofol, dexmedetomidine, and midazolam for adult sedation in flexible bronchoscopy: a systematic review and meta-analysisBACKGROUND: Remimazolam, a short-acting benzodiazepine, has emerged as a potential safer alternative for sedation in Flexible Bronchoscopy (FB). This meta-analysis compares its efficacy and safety with Propofol, Dexmedetomidine, and Midazolam in adult patients undergoing FB. METHODS: PubMed, Embase, and Cochrane databases were searched on July 17, 2025, for trials comparing Remimazolam with other sedatives. Primary outcomes included hypotension, bradycardia, and intraprocedural opioid consumption; secondary outcomes were hypoxia, respiratory depression, patient satisfaction, induction time, and recovery time. Pooled Risk Ratios (RR), Mean Differences (MD), and Standardized Mean Differences (SMD) were calculated using a random-effects model in R (4.4.0). Risk of bias was assessed using the RoB2 tool, and subgroup analyses were conducted for each comparator. RESULTS: Eleven trials (1,884 patients) were included. Remimazolam reduced respiratory depression (RR = 0.44 [95% CI 0.29; 0.67]; p = 0.0002; I² = 0%), hypoxia incidence (RR = 0.60 [95% CI 0.39; 0.93]; p = 0.0227; I² = 64.7%), bradycardia (RR = 0.39 [95% CI 0.20; 0.77]; p = 0.0069; I² = 52.3%), and hypotension (RR = 0.61 [95% CI 0.40; 0.95]; p = 0.0289; I² = 74.0%) compared to all sedatives. Compared to Propofol, Remimazolam reduced the incidence of hypotension (RR = 0.42 [95% CI 0.31; 0.58]; p < 0.0001; I² = 0%), respiratory depression (RR = 0.41 [95% CI 0.25; 0.68]; p = 0.0005; I² = 12.3%), but increased induction time (MD = 0.61 min [95% CI 0.23; 0.99]; p = 0.002; I² = 90.9%). Compared to Dexmedetomidine, it improved satisfaction (SMD = 0.23 [95% CI 0.07; 0.39]; p = 0.004; I² = 0%) and reduced recovery time (MD = -1.79 min [95% CI -2.66; -0.92]; p < 0.001; I² = 90.7%), hypoxia incidence (RR = 0.49 [95% CI 0.28; 0.88]; p = 0.0162; I² = 60.3%), and induction time (MD = -2.21 min [95% CI -2.41; -2.00]; p < 0.001; I² = 0%). Compared to Midazolam, Remimazolam increased sedation success (RR = 2.03 [95% CI 1.40; 2.95]; p = 0.0002; I² = 50%), shortened induction time (MD = -0.69 min [95% CI -1.37; -0.01]; p = 0.047; I² = 81.5%), and recovery time (MD = -4.49 min [95% CI -7.06; -1.92]; p < 0.001; I² = 40.9%). CONCLUSIONS: Remimazolam reduced respiratory depression overall and demonstrated improved safety, faster recovery, and greater efficacy compared to Propofol, Dexmedetomidine, and Midazolam, respectively, supporting its potential as an effective alternative for sedation in FB. Nonetheless, substantial heterogeneity in certain outcomes and the relatively small sample size in some comparisons limit the generalizability of our findings. SYSTEMATIC REVIEW PROTOCOL: PROSPERO (CRD 42024568148).Luiz Fábio Silva Ribeiro; Lucas Rezende de Freitas; Tauãna Terra Cordeiro de Oliveira; Laiz Gomes Carneiro Novaes; Rafael Arsky Lombardi

Midazolam; Sedation; Hypnotic; Action (physics); Benzodiazepine; Medicine; Anesthesia

2026-01-24https://doi.org/10.1016/j.bjane.2026.844729Brazilian Journal of Anesthesiology (English Edition) 20261Dataset of IoT Monitoring and Energy Consumption in a Smart Laboratory for EducationRodrigo Mendes Peixoto

Energy consumption; Internet of Things; Energy (signal processing); Consumption (sociology); Data collection; Key (lock); Computer science; Real-time computing

2026-01-24https://doi.org/10.5281/zenodo.18361326Zenodo (CERN European Organization for Nuclear Research) 20261Review of case studies on innovation initiatives in the Brazilian Construction IndustryDanielle Rios Garcia; Samara de Carvalho Pedro; Juliana Barros de Oliveira; Júlia Castro Mendes

Productivity; Workforce; Construction industry; Relevance (law); Process (computing); Construction management; Resistance (ecology); Business; Variety (cybernetics); Social impact; Business failure; Economic growth

2026-01-01https://doi.org/10.2139/ssrn.6124339SSRN Electronic Journal 20261Post-Newtonian expansion of scale-dependent gravityScale-dependent gravity is an extension of general relativity in which the Newton and cosmological constants may vary slightly with the energy scale due to remnant low-energy quantum effects. A fundamental feature of this approach is the scale-setting procedure. In a previous work, a covariant expression for the scale, consistent with conservation laws, was established. Here, we apply the full Will-Nordtvedt version of the parameterized post-Newtonian (PPN) formalism to this framework, assuming that the constants can be expressed as a power series in the scale. We find that a new potential arises at the first post-Newtonian order, which is absent from the standard PPN formalism. This potential modifies the definitions of pressure and internal energy but does not affect center-of-mass orbits and is, therefore, not constrained by Solar System tests.Nicolas R. Bertini; Marcos H. Novaes

Covariant transformation; Quantum gravity; Formalism (music); Parameterized complexity; General relativity; f(R) gravity; Power series; Quantum; Physics; Classical mechanics; Gravitation; Expression (computer science); Potential energy

2026-01-22https://doi.org/10.1103/s2c1-gndlPhysical review. D/Physical review. D. 20261Avaliação do uso de terapia de reposição hormonal em mulheres no climatério e menopausaObjetivo: Avaliar a frequência do uso da terapia de reposição hormonal (TRH) e seus efeitos sobre os sintomas e a percepção de bem-estar em mulheres climatéricas e menopausadas. Métodos: Estudo transversal com 264 mulheres em climatério e menopausa, avaliadas por meio de questionário online aplicado entre novembro de 2024 e outubro de 2025. Foram incluídas variáveis clínicas, sintomas, tipo de TRH e percepção de qualidade de vida. O nível de significância adotado foi de p < 0,05. Resultados: A média de idade foi de 54 ± 7,17 anos, com menopausa aos 47,4 ± 5,91 anos. Os sintomas mais prevalentes foram fogachos (48,8%), insônia (22,7%) e irritabilidade (17,7%). Apenas 41,3% utilizavam TRH, sendo o gel transdérmico (27,5%) e a via oral (22,9%) as formas mais empregadas. Entre as não usuárias, o principal motivo foi a ausência de prescrição médica (48,3%). Entre as usuárias, 80% relataram boa adaptação e 61,1% melhora expressiva da qualidade de vida. Conclusão: A TRH mostrou impacto positivo na qualidade de vida e no controle dos sintomas climatéricos, mas ainda é subutilizada devido ao receio de riscos e à hesitação médica na prescrição.Ana Luisa Teixeira; Ana Luiza Vieira Campos Bráulio; Flavyanne Salles Silva; LIVIA RODARTE PINTO DE AGUIAR; Marina Camargos de Figueirêdo Neves; Nayla Yasmin Faria da Silva; Juliana Barroso Zimmermmann

Quality of life (healthcare); Population; Hormone; Randomized controlled trial; Incidence (geometry); Medicine; Gynecology

2026-01-22https://doi.org/10.25248/reas.e22699.2026Revista Eletrônica Acervo Saúde 20261Dataset of IoT Monitoring and Energy Consumption in a Smart Laboratory for EducationRodrigo Mendes Peixoto

Energy consumption; Internet of Things; Energy (signal processing); Consumption (sociology); Data collection; Key (lock); Computer science; Real-time computing

2026-01-24https://doi.org/10.5281/zenodo.18361327Zenodo (CERN European Organization for Nuclear Research) 20261Emotion regulation and body image across the eating disorder symptom severity spectrum: a comparative analysis of young and middle-aged womenEating disorders (EDs) are rising, yet research predominantly focuses on younger women, leaving midlife women understudied. This study examined how emotion dysregulation and body image concerns relate to disordered eating symptoms across emerging adulthood (EA, 18–30 years) and middle adulthood (MA, 45–65 years) and across levels of ED symptom severity. Participants were 1055 women (317 EA lower-symptom-severity, 298 MA lower-symptom-severity, 211 EA higher-symptom-severity, 229 MA higher-symptom-severity). Emotion dysregulation was measured with the Difficulties in Emotion Regulation Scale-18 (DERS-18), body image concerns with the Body Image Concerns Inventory (BICI), and disordered eating symptoms with the Eating Disorder Examination Questionnaire (EDE-Q) and the Eating Attitudes Test-26 (EAT-26). Psychometric analyses, including confirmatory factor analyses and measurement invariance testing are detailed in the Supplemental Materials. Multiple-group structural equation modeling (MGSEM) was conducted to examine whether associations between predictors and outcomes differed by age and symptom severity. Associations varied across age and symptom severity. Difficulties with emotional clarity, impulse control, and appearance dissatisfaction were consistently associated with higher ED symptoms, whereas greater emotional awareness was linked to lower symptoms in some groups. Difficulties with goal-directed behaviors, nonacceptance, limited access to emotion regulation strategies, and social avoidance showed both positive and negative associations depending on age and symptom severity. Findings underscore the need for developmentally informed, transdiagnostic approaches to ED prevention beyond early adulthood. Subscale-level analyses revealed that commonly defined “risk factors” may also be associated with adaptive or protective patterns, highlighting the complexity of these associations across the female lifespan. These insights support more nuanced, strength-based approaches to inform early detection, prevention, and intervention across the ED spectrum. Eating disorders (EDs) can affect individuals at any age, yet most research has focused on young women, leaving women in midlife underrepresented. This study explored how difficulties with managing emotions and concerns about body image relate to ED symptoms in younger (emerging adult) and middle-aged women, and across different levels of symptom severity. We found that body image concerns were strongly linked to ED symptoms in all groups, though in some cases, appearance-related avoidance was also associated with lower body dissatisfaction, suggesting a more complex role. Emotion regulation difficulties were more strongly tied to ED symptoms in middle-aged women, and some aspects of emotion regulation—such as emotional awareness—were consistently linked to lower ED symptoms, showing potential resilience. These findings highlight the importance of considering both age and severity when understanding and treating EDs. They also point to the need for prevention and treatment approaches that are tailored to women’s emotional and body image experiences at different stages of life.Maria Bazo Perez; Pedro Henrique Berbert de Carvalho; Leslie D. Frazier

Intervention (counseling); Eating disorders; Disordered eating; Young adult; Affect (linguistics); Psychology; Clinical psychology; Developmental psychology; Medicine

2026-01-26https://doi.org/10.1186/s40337-026-01531-yJournal of Eating Disorders 20261Raw data supporting the study: Prebiotic-like and antioxidant properties of Pereskia aculeata leaf mucilage in the modulation of skin-associated bacteriaThis repository contains the raw and processed datasets (Excel files) supporting the findings reported in the manuscript entitled “Prebiotic-like and antioxidant properties of Pereskia aculeata leaf mucilage in the modulation of skin-associated bacteria”, submitted to the Journal of Applied Microbiology. The data include experimental measurements and statistical analyses used to generate the results presented in the study.Elita Scio

Mucilage; Mucilage; Antioxidant; Antioxidant; Aculeata; Aculeata; Raw material; Raw material; Chemistry; Food science; Bacteria; Botany

2026-01-25https://doi.org/10.5281/zenodo.18367155Zenodo (CERN European Organization for Nuclear Research) 20261Raw data supporting the study: Prebiotic-like and antioxidant properties of Pereskia aculeata leaf mucilage in the modulation of skin-associated bacteriaThis repository contains the raw and processed datasets (Excel files) supporting the findings reported in the manuscript entitled “Prebiotic-like and antioxidant properties of Pereskia aculeata leaf mucilage in the modulation of skin-associated bacteria”, submitted to the Journal of Applied Microbiology. The data include experimental measurements and statistical analyses used to generate the results presented in the study.Elita Scio

Mucilage; Mucilage; Antioxidant; Antioxidant; Aculeata; Aculeata; Raw material; Raw material; Chemistry; Food science; Bacteria; Botany

2026-01-25https://doi.org/10.5281/zenodo.18367154Zenodo (CERN European Organization for Nuclear Research) 20261Predictive Factors of Better Patient Satisfaction After Phenol‐Croton Peel: A Retrospective Study of 102 PatientsBACKGROUND: Phenol-croton peels are the gold standard for treating sun-damaged skin and static wrinkles; their long-term outcomes and patient satisfaction rates have yet to be thoroughly investigated. AIMS: To evaluate patient satisfaction and both short- and long-term cutaneous side effects in individuals undergoing phenol-croton peels. MATERIALS AND METHODS: This retrospective cohort study analyzed 102 female patients who underwent phenol-croton peels and were followed up until 3 months after the procedure to assess short-term side effects and to identify any long-term side effects that persisted beyond this period. Univariate and multivariate analyses were performed to assess patient satisfaction and long-term cutaneous side effects. RESULTS: Ninety-two percent of patients rated their satisfaction as 4 or 5. Persistent cutaneous side effects were observed in 12% of cases (hypopigmentation: 6, hyperpigmentation: 5, dryness: 1). Despite mild hypopigmentation, five patients expressed willingness to undergo the procedure again. In the univariate analyses, full-face treatment, increasing age, and the absence of cutaneous side effects were significantly associated with higher satisfaction scores (p < 0.05). In the multivariate model, age and the absence of cutaneous side effects remained independently and significantly associated with the outcome. Full-face treatment, although not statistically significant in the final model, showed a trend toward association and contributed to the overall adjustment. Notably, cutaneous side effects decreased at follow-up performed at least 15 months after the procedure compared to follow-up conducted within 3 months post-procedure (p = 0.039). CONCLUSIONS: Phenol-croton peels demonstrated high satisfaction rates despite occasional prolonged cutaneous side effects. However, these side effects significantly decreased at ≥ 15 months post-procedure compared to ≤ 3 months post-procedure. Careful patient selection and expertise in performing this procedure remain crucial for optimizing outcomes.Gustavo Carneiro Nogueira; Raquel Iracema de Freitas Macedo Oliveira; Mariana Rocha Andrade; Bárbara Arze Rocha; Naides Carneiro Nogueira; Márcio Roberto Silva; Ana Carolina Tardin Rodrigues de Medeiros; Marina Vieira Rodrigues de Queiroz; Felipe Xavier Cló; Ticiano Teixeira Cesar Clo; Carlos Gustavo Wambier; Gisele Viana de Oliveira

Patient satisfaction; Retrospective cohort study; Selection (genetic algorithm); Patient experience; MEDLINE; Patient data; Medicine; Emergency medicine; Physical therapy; Patient care; Surgery; Health care

2026-01-25https://doi.org/10.1111/jocd.70609Journal of Cosmetic Dermatology 20261The Intestine: Development, Functions, and Its Impact on Disease Risk across the LifespanThe intestine plays a central role in the immune system, continuously interacting with antigens, dietary components, and the microbiota. Intestinal immune processes are increasingly recognized for their influence on the development of both local and systemic diseases, with long-term effects on health and disease progression. This review provides an overview of intestinal development, encompassing its maturation from conception, temporal changes, regenerative capacity, interactions with the microbiota, and involvement in disease. Early life, particularly critical periods such as pregnancy and lactation, may represent a "window of opportunity," establishing lasting conditions that either increase disease risk or confer protection in adulthood. Understanding the regulatory factors, regional and temporal variations, and existing knowledge gaps is essential for guiding clinical practice, as well as for the prevention and treatment of diseases.Poliana Guiomar de Almeida Brasiel; Sheila Cristina Potente Dutra Luquetti

Disease; Immune system; Pregnancy; Disease prevention; Risk assessment; Medicine; Intensive care medicine; Immunology

2026-01-20https://doi.org/10.2174/0115733963400365251201134405Current Pediatric Reviews 20261Melatonin Alleviates Aluminum Toxicity in Pfaffia glomerata by Modulating Tolerance MechanismsAbstract Aluminum (Al) toxicity is the main factor limiting agricultural production in acidic soils around the world. In this scenario, melatonin (MET) has emerged as a promising approach to alleviate Al toxicity. Thus, we investigated morphophysiological responses of Pfaffia glomerata (Spreng.) Pedersen, a medicinal plant, to Al toxicity and MET application. Plants were grown in vitro for 40 days in MS medium (control) supplemented with Al, MET, and Al + MET. Aluminum had genotoxic effects, inducing DNA damages and endoreduplication, which resulted in growth arrest, mainly in roots. Al also decreased the photosynthetic rate and the contents of pigments, carbohydrates, amino acids, and proteins. On the other hand, all these effects were improved in plants supplemented with MET. This is supported by the up-accumulation of proteins involved in organic acids exudation (AHA2), photosynthesis (transketolase, rubisco activase, and photosystem I P700 apoprotein A2), amino acid biosynthesis (chorismate synthase 1 and aspartokinase/homoserine dehydrogenase), and cell expansion and differentiation (rough sheath 2, beta tubulin b6, and tubulin beta chain-like). Moreover, MET enhanced CAT, SOD, and GABA, reinforcing its antioxidant role and reducing DNA damage and endoreduplication, which preserved QC identity and root elongation. Al toxicity impaired growth and carbon–nitrogen metabolism, whereas MET mitigated these effects by boosting photosynthesis, antioxidant defenses, and Al sequestration, decreasing Al adherence to roots. Thus, MET serves as a protective molecule against Al toxicity in P. glomerata .Michelle M. V. Almeida; Juliane M. Henschel; Tatiane D. Silva; Luiza E. G. Monteiro; Mateus S. Rodrigues; Tadeu R. Oliveira; Auxiliadora O. Martins; Sérgio H. S. Felipe; Evandro A. Fortini; Elyabe M. Matos; Lyderson F. Viccini; Diego S. Batista; Claudete Santa-Catarina; Vanildo Silveira; Wagner L. Araújo; Wagner C. Otoni

Toxicity; Antioxidant; Photosynthesis; Melatonin; Photosystem II; RuBisCO; Plant physiology; Photosynthetic efficiency; Biochemistry; Chemistry; Biology; Pharmacology; Growth inhibition; DNA damage; Amino acid

2026-01-27https://doi.org/10.1007/s00344-025-12031-9Journal of Plant Growth Regulation 20261Energy recovery from the anaerobic co-digestion of ricotta cheese whey and dairy cattle manureThis study evaluated biogas production, methane concentration and yield, as well as the potential for energy production of anaerobic co-digestion of ricotta cheese whey and dairy cattle manure in 60 L plug flow reactors. Four reactors were operated: three with different proportions of ricotta cheese whey (20, 40, and 80%) and a control reactor containing only dairy cattle manure. The reactors were operated for 106 days, with a hydraulic retention time of 30 days. In all reactors, pH remained near neutrality, and alkalinity stayed above 2,500 mg L⁻¹. Notably, only the reactor with 80% ricotta cheese whey demonstrated more efficient removal of total solids, volatile solids, biochemical oxygen demand, and chemical oxygen demand, with average reductions of 54, 69, 69, and 78%, respectively. However, the reactor operated with 40% ricotta cheese whey produced the highest accumulated biogas volume, surpassing the 80% ricotta cheese whey reactor by 36 L, with a realistic extrapolation of electricity production estimated at 1.67 kWh m-³. Although methane yields were close to theoretical maximum values and methane concentrations showed no significant differences between treatments, the results confirm the effectiveness of anaerobic co-digestion in the treating of agro-industrial waste. The 40% ricotta cheese whey and 60% dairy cattle manure ratio stands as a promising alternative for biogas production.Larice Aparecida Santana; Guilherme Henrique Da Silva; Jailton da Costa Carneiro; Isabela Gomes Da Motta; Henrique Vieira de Mendonça; Marcelo Henrique Otênio

Biogas; Manure; Dairy cattle; Alkalinity; Anaerobic exercise; Methane; Bioenergy; Chemistry; Anaerobic digestion; Pulp and paper industry; Total dissolved solids; Food science; Hydraulic retention time

2026-01-18https://doi.org/10.14393/bj-v42n0a2026-75046Bioscience Journal 20261AShE – A Shadow Estimator for Augmented Reality Systems on Mobile PlatformsThis work presents a geometric method for estimating the directional light vector in a scene, enabling realistic shadow generation in augmented reality through image segmentation and inverse rendering. The solution is designed for mobile devices, eliminating the need for specialized hardware and machine learning-based algorithms. The method employs standard cameras and fiducial markers to project realistic shadows on virtual objects, ensuring coherent visual integration with the real environment. The experiments demonstrated that the proposed approach achieved an average angular error of 11.42° for synthetic datasets, effectively estimating scene illumination and generating visually convincing shadow projections. Qualitative tests indicate that the system performs well under various lighting conditions, although it faces limitations in scenarios with translucent objects or diffuse lighting. The results suggest that this solution can serve as an efficient and accessible alternative for augmented reality applications on mobile devices, enhancing immersion and realism without requiring complex computational infrastructure.André Luís Braga Dutra; Rodrigo Luis de Souza da Silva

Augmented reality; Shadow (psychology); Segmentation; Mobile device; Virtual reality; Estimator; Fiducial marker; Computer vision; Computer science; Artificial intelligence; Computer graphics (images); Shadow mapping; Image segmentation; Visualization

2026-01-23https://doi.org/10.5753/jis.2026.6127Journal on Interactive Systems 20261A Digital Game to Motivate and Empower Women in Learning Algorithms for Computer ScienceBackground: High dropout and failure rates in introductory Computer Science courses, such as Algorithms, represent a challenge, with dropout rates particularly high among female students. Traditional teaching methods do not always maintain engagement, highlighting the need for innovative approaches that promote motivation and learning. Purpose: This study proposes the development of ProgramADAs, a digital educational game to support female undergraduate students in Computer Science and related fields. The goal of the game is to stimulate interest in the Algorithms course by providing an engaging learning experience and contributing to the reduction of dropout and failure rates. Methods: ProgramADAs was developed by students who have previously taken Algorithms, allowing their experiences to shape the creation of an educational game aligned with the challenges faced by female students. The game is customizable and incorporates game elements to promote engagement. To evaluate its effectiveness, the authors conducted two studies: the first analyzed the game’s potential as a motivational strategy, and the second assessed its usability and player experience. Results: The results indicate that ProgramADAs has significant potential as a motivational teaching tool. The usability evaluation yielded positive scores, suggesting that the game is educationally relevant and effective in supporting the teaching and learning of Algorithms. Conclusion: The results suggest that ProgramADAs has the potential to increase female students’ engagement in Algorithms. Its interactive and customizable features make it a valuable resource for improving the learning experience and addressing challenges of motivation and retention in Computer Science.Luana Lauschner Avilez Vilarinho; Bárbara de Melo Quintela; Luciano Jerez Chaves; Pedro Henrique Dias Valle; Alessandreia Marta de Oliveira

Dropout (neural networks); Usability; Game based learning; Educational game; Game design; Resource (disambiguation); Computer game; Serious game; Computer science; Multimedia; Game play; Game Developer

2026-01-22https://doi.org/10.5753/jis.2026.5626Journal on Interactive Systems 20261Carnitine Deficiency Cardiomyopathy: A Rare Late Diagnosis in AdulthoodThaiz Ruberti Schmal; leonardo Rodrigo Castilho; Bernardo Augusto Lima; Pedro Lawall Carvalho; Camille Schmal Santos; Natalya Goncalves Pereira; Helio Lima Brito Jr.

Angiology; MEDLINE; Carnitine; Young adult; Medicine; Internal medicine; Pediatrics; Endocrinology; Gastroenterology

2026-01-01https://doi.org/10.1016/j.jocmr.2025.102200Journal of Cardiovascular Magnetic Resonance 20261Synchronous Telemedicine Versus In‐Person Care in Hepatitis C Treatment: A Systematic Review and Meta‐AnalysisInequitable access to HCV treatment persists, particularly for rural and marginalised populations. Synchronous telemedicine (TM) could mitigate access barriers, but its comparative effectiveness versus in-person care is uncertain. We performed a systematic review and meta-analysis comparing synchronous TM with in-person care for HCV. The primary outcome was sustained virologic response (SVR); secondary outcomes were treatment initiation and completion. Subgroup analyses examined study design, therapy era (interferon vs. direct-acting antivirals [DAAs]), and setting (rural vs. non-rural). Narrative synthesis addressed people who use drugs (PWUD), incarcerated populations, pandemic-era cohorts, and economic evaluations. Fifteen studies involving 7.459 patients (2 RCTs, 13 observational) were included (13 meta-analysed). For SVR, the pooled effect showed no significant difference between interventions (odds ratio [OR] 1.60, 95% CI 0.69-3.68). Treatment initiation and completion were also not significantly different overall (initiation OR 7.59, 95% CI 0.79-72.81; completion OR 2.50, 95% CI 0.76-8.25), although exclusion of single influential studies yielded significant benefits for TM in sensitivity analyses. Subgroups suggested context-specific advantages: TM favoured SVR in rural settings (OR = 4.19, 95% CI 1.28-13.73) and in RCTs (OR = 10.42, 95% CI 7.41-14.67). Narrative evidence indicated that TM improved linkage and cure among PWUD and incarcerated individuals, preserved efficacy during COVID-19, and reduced costs. Overall, synchronous TM seems comparable to in-person care overall and may be superior in rural and marginalised populations.Igor Boechat Silveira; Gustavo Procópio Silva; Arthur Victor de Holanda Sampaio; Milena Ramos Tomé; Jingying Elena Chen; Alana Vitória Santos de Jesus; Guilherme Grossi Lopes Cançado

Psychological intervention; Telemedicine; Hepatitis C; Primary care; Narrative review; MEDLINE; Hepatitis C virus; Chronic hepatitis; Medicine; Internal medicine; Intensive care medicine; Linkage (software); Family medicine; Rural area; Subgroup analysis

2026-01-28https://doi.org/10.1111/jvh.70144Journal of Viral Hepatitis 20261Competition or Collusion? Bid-Level Evidence from Medical Gas ProcurementThis document consists of the R and Python codes containing the results for the development of the article "Competition or Collusion?Bid-Level Evidence from Medical Gas Procurement"Luan Michel Soares Pereira; Claudio Ribeiro Lucinda; Douglas Silveira

Procurement; Competition (biology); Gas industry; Government procurement; Third party; Business; Industrial organization; Commerce

2026-01-29https://doi.org/10.5281/zenodo.18407984Zenodo (CERN European Organization for Nuclear Research) 20261Competition or Collusion? Bid-Level Evidence from Medical Gas ProcurementThis document consists of the R and Python codes containing the results for the development of the article "Competition or Collusion? Bid-Level Evidence from Medical Gas Procurement".Luan Michel Soares Pereira; Claudio Ribeiro Lucinda; Douglas Silveira

Procurement; Competition (biology); Gas industry; Government procurement; Third party; Business; Industrial organization; Commerce

2026-01-29https://doi.org/10.5281/zenodo.18407859Zenodo (CERN European Organization for Nuclear Research) 20261Competition or Collusion? Bid-Level Evidence from Medical Gas ProcurementThis document consists of the R and Python codes containing the results for the development of the article "Competition or Collusion? Bid-Level Evidence from Medical Gas Procurement".Luan Michel Soares Pereira; Claudio Ribeiro Lucinda; Douglas Silveira

Procurement; Competition (biology); Gas industry; Government procurement; Third party; Business; Industrial organization; Commerce

2026-01-29https://doi.org/10.5281/zenodo.18407860Zenodo (CERN European Organization for Nuclear Research) 20261Previne Brasil: avaliação do indicador de gestantes com exames para sífilis e HIV no período de 2018 a 2023Objetivo: Avaliar o perfil epidemiológico e o conhecimento de gestantes e puérperas sobre saúde bucal, bem como a efetividade de ações educativas realizadas por acadêmicos de odontologia na Atenção Primária à Saúde. Métodos: Estudo transversal, quantitativo e descritivo com 33 mulheres e 20 acadêmicos de odontologia. Aplicaram-se questionários e palestras educativas sobre aleitamento materno e higiene bucal, avaliando o conhecimento antes e após as ações. Resultados: A maioria das participantes apresentou baixa escolaridade e vulnerabilidade socioeconômica, além de desconhecimento sobre cuidados odontológicos próprios e do bebê. Após as intervenções, observou-se melhora significativa no aprendizado e adesão às práticas preventivas, além de maior procura por atendimento odontológico. Conclusão: As ações educativas mostraram-se eficazes na ampliação do conhecimento em saúde bucal e na integração ensino-serviço-comunidade, reforçando a importância da atuação do cirurgião-dentista e dos acadêmicos junto às gestantes e puérperas.Laura Bassoli Baldiotti Benicio; Thais de Oliveira Gozzo; N. Caldeira; Lise Maria Carvalho Mendes; Fábio da Costa Carbogim; Flávia Azevedo Gomes- Sponholz; Nayara Gonçalves Barbosa

Human immunodeficiency virus (HIV); Breastfeeding; Primary care; Primary health care; Breast feeding; Medicine; Gynecology

2026-01-29https://doi.org/10.25248/reas.e21665.2026Revista Eletrônica Acervo Saúde 20261Impact of Multimodal Right Ventricular Assessment in Patients with Resistant Hypertension and Obstructive Sleep ApneaThaiz Ruberti Schmal; Leonardo H. Mendonca; Pedro H.P. Guimaraes; Pedro Gorgulho Martins; Ludimila O.C. Ouverney; JOSE RODRIGUEZ CASTRO; G. Lorenzi; Thiago G.S. Souza

Obstructive sleep apnea; Resistant hypertension; Angiology; Sleep apnea; MEDLINE; Medicine; Cardiology; Internal medicine

2026-01-01https://doi.org/10.1016/j.jocmr.2025.102355Journal of Cardiovascular Magnetic Resonance 20261Direita radical, populismo e democraciaEm consequência do declínio universal do regime democrático, partidos de direita radical (PDRs) estão ganhando influência política e poder através de eleições democráticas e já não mais por golpes de estado ou meios extraconstitucionais. Passaram a conquistar assentos em legislaturas nacionais e regionais, posições em gabinetes e na chefia de Estados. Tal fenômeno tem inspirado uma plêiade de estudos sobre os PDRs, sob diferentes abordagens, alguns dos quais procuram descrever o tipo de eleitor que está na base de tal sucesso. Há um consenso na literatura que a extrema direita utiliza estratégias ancoradas na evocação de discursos de ódio alinhados ao populismo, à xenofobia, ao racismo, à homofobia e à intolerância disseminadas no seio das sociedades. Cabe assinalar ainda que tais estratégias sinalizam uma espécie de colonização do imaginário popular, e assim salientam a importância do universo cultural e simbólico enquanto dimensão central de uma disputa por hegemonia e poder. Objetivo: Este artigo se propõe identificar as estratégias políticas e os componentes ideológicos- culturais comuns entre os apoiadores da direita radical nos Estados Unidos, na Alemanha e no Brasil. Tal escolha se justifica pelo peso político e econômico desses países, bem como sua capacidade de “exportar” o modelo antidemocrático para países da América e Europa. Conclusão: O artigo conclui que apesar de todas ameaças, a democracia nos países estudados tem se mostrado resiliente em parte como reação ao próprio radicalismo da extrema-direita. Tal movimento de resistência tem sido liderado por todos aqueles que foram “agredidos pela realidade”.Orlando Lyra de Carvalho Júnior

Government (linguistics); Democracy; Politics; Order (exchange); State (computer science); Political science; Philosophy; Humanities

2026-01-26https://doi.org/10.23925/1982-6672.2025v17i52p156-179Aurora Revista de Arte Mídia e Política 20261Competition or Collusion? Bid-Level Evidence from Medical Gas ProcurementThis document consists of the R and Python codes containing the results for the development of the article "Competition or Collusion?Bid-Level Evidence from Medical Gas Procurement"Luan Michel Soares Pereira; Claudio Ribeiro Lucinda; Douglas Silveira

Procurement; Competition (biology); Gas industry; Government procurement; Third party; Business; Industrial organization; Commerce

2026-01-29https://doi.org/10.5281/zenodo.18407983Zenodo (CERN European Organization for Nuclear Research) 20261Conceptual evolution and methodological challenges of value-added in educational assessment: A scoping review 1971–2024It refers to the bibliometric data used in the study “Conceptual Evolution and Methodological Challenges of Value-Added in Educational Assessment: A Scoping Review (1971–2024).”Kelly Alice Barbosa Macêdo; Maria Eugénia Ferrão; Vieira, Marcel de Toledo

Field (mathematics); Perspective (graphical); Qualitative research; Context (archaeology); Work (physics); Research methodology; Engineering ethics; Sociology; Management science; Epistemology; Knowledge management; Data science

2026-01-01https://doi.org/10.5281/zenodo.18409731Open MIND 20261NFT Collection Classification: A Multimodal Approach Integrating Metadata and Textual Embeddings with Supervised LearningSamuel de Oliveira Ribeiro; Markesley Ramos do Nascimento; Dayan Ramos Gomes; Saulo Moraes Villela; Glauber Dias Gonçalves

Metadata; Preprocessor; Embedding; Supervised learning; Class (philosophy); Semi-supervised learning; Multimodal learning; Computer science; Artificial intelligence; Natural language processing; Machine learning; Word embedding; Data pre-processing; Deep learning; Information retrieval; Training set; Semantics (computer science)

2026-01-01https://doi.org/10.1007/978-3-032-15984-7_17Lecture notes in computer science 20261On the Combination of Machine Learning Techniques with Simulated Annealing to Identify Professional Accounts in EthereumJúlia Almeida Valadares; Saulo Moraes Villela; Heder Soares Bernardino; Alex Borges Vieira

Simulated annealing; Precision and recall; Artificial neural network; Deep learning; Training set; Computer science; Machine learning; Artificial intelligence; Data mining

2026-01-01https://doi.org/10.1007/978-3-032-15984-7_18Lecture notes in computer science 20261COI based phylogeny and morphological characterization of a Brazilian population of Lambornella trichoglossa (Ciliophora: Tetrahymenidae)In this work, the morphological characterization and molecular phylogeny (SSU rDNA and COI) of Lambornella trichoglossa Foissner, 2003, found in phytotelmata environments in southeastern Brazil is presented. The morphological study performed with silver impregnation techniques demonstrated parameters similar to those recorded in the type population, and additional new information was also obtained, including the conjugation process and the occurrence of specimens with an increased number of caudal cilia. The phylogenetic reconstructions based on both markers suggest the inclusion of L. trichoglossa in the genus Tetrahymena Furgason, 1940. The COI sequence obtained in this work is the first mitochondrial sequence of the genus Lambornella deposited in GenBank and published in a scientific article.Vítor Ribeiro-Halfeld

Phylogenetics; Phylogenetic tree; Genus; GenBank; Molecular phylogenetics; Morphology (biology); Biology; Evolutionary biology; Population; Zoology; Type (biology); Mitochondrial DNA; Sequence (biology); Taxonomy (biology); Morphological analysis

2026-01-27https://doi.org/10.22201/ib.20078706e.2026.97.5732Revista Mexicana de Biodiversidad 20261Conceptual evolution and methodological challenges of value-added in educational assessment: A scoping review 1971–2024Refers to: The bibliometric data used in the study “Conceptual evolution and methodological challenges of value aggregation in educational evaluation: a scoping review (1971–2024)”. The appendix of the study.Kelly Alice Barbosa Macêdo; Maria Eugénia Ferrão; Vieira, Marcel de Toledo

Value (mathematics); Field (mathematics); Conceptual framework; Work (physics); Research methodology; Engineering ethics; Management science; Sociology; Epistemology; Data science; Knowledge management; Computer science

2026-01-01https://doi.org/10.5281/zenodo.18409730Zenodo (CERN European Organization for Nuclear Research) 20261Measurement of the top-quark Yukawa coupling from $$ t\overline{t} $$ production in the lepton+jets final state using pp collisions at $$ \sqrt{s}=13 $$ TeV with the ATLAS detectorA bstract The top-quark Yukawa coupling is extracted from the distribution of the top-quark pair ( $$ t\overline{t} $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mi>t</mml:mi> <mml:mover> <mml:mi>t</mml:mi> <mml:mo>¯</mml:mo> </mml:mover> </mml:math> ) invariant mass in proton-proton collisions using 140 fb − 1 of data at $$ \sqrt{s}=13 $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msqrt> <mml:mi>s</mml:mi> </mml:msqrt> <mml:mo>=</mml:mo> <mml:mn>13</mml:mn> </mml:math> TeV collected in 2015–2018 by the ATLAS experiment at the Large Hadron Collider. In the region near the production threshold, the $$ t\overline{t} $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mi>t</mml:mi> <mml:mover> <mml:mi>t</mml:mi> <mml:mo>¯</mml:mo> </mml:mover> </mml:math> invariant mass spectrum is sensitive to electroweak virtual corrections, including contributions from Higgs boson exchange, thereby providing sensitivity to the top-quark Yukawa coupling. This is the first measurement in ATLAS that aims to obtain this coupling exploiting this approach. The $$ t\overline{t} $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mi>t</mml:mi> <mml:mover> <mml:mi>t</mml:mi> <mml:mo>¯</mml:mo> </mml:mover> </mml:math> system is reconstructed in the single-lepton final state, requiring exactly one isolated electron or muon and at least four jets with at least two identified as originating from b -quarks. The measured Yukawa coupling is found to be in good agreement with the Standard Model prediction. An upper limit on the top-quark Yukawa coupling strength of Y t < 2 . 1 relative to the Standard Model prediction is observed at 95% confidence level, consistent with the expected sensitivity.Georges Aad; E. Aakvaag; B. Abbott; S. Abdelhameed; Karin Abeling; N. J. Abicht; S. H. Abidi; Mohammed Aboelela; A. Aboulhorma; H. Abramowicz; Y. Abulaiti; B. S. Acharya; Alexander Ackermann; C. Adam Bourdarios; L. Adamczyk; S. V. Addepalli; M. J. Addison; J. Adelman; A. Adiguzel; T. Adye; A. A. Affolder; Y. Afik; M. N. Agaras; A. Aggarwal; F. Ahmadov; F. Ahmadov; S. Ahuja; S. Ahuja; X. Ai; G. Aielli; A. Aikot; M. Ait Tamlihat; Brahim Aitbenchikh; T. P. A. Åkesson; A. V. Akimov; D. Akiyama; N. N. Akolkar; S. Aktas; G. L. Alberghi; Jeffrey Ryan Albert; Una Helena Alberti; P Albicocco; G. L. Albouy; S. Alderweireldt; Z. L. Alegria; Martin Aleksa; I. N. Aleksandrov; Călin Alexa; T. Alexopoulos; F. Alfonsi; M. Algren; B. Ali; B. Ali; H. M. J. Ali; S. Ali; S. W. Alibocus; M. Aliev; G. Alimonti; W. Alkakhi; C. Allaire; B. M. M. Allbrooke; D. R. Allen; J. S. Allen; J. S. Allen; P. P. Allport; A. Aloisio; Fernando Martín Alonso; C. Alpigiani; Z. M. K. Alsolami; A. Alvarez Fernandez; M. Alves Cardoso; M. G. Alviggi; Moustafa H. Aly; Y. Amaral Coutinho; A. Ambler; C. Amelung; M. Amerl; C. G. Ames; T. Amezza; D. Amidei; B. Amini; K. Amirie; A. Amirkhanov; S. P. Amor Dos Santos; K. R. Amos; D. Amperiadou; S. An; C. Anastopoulos; T. Andeen; J. K. Anders; A. C. Anderson; A. Andreazza; S. Angelidakis; A. Angerami; A. V. Anisenkov; A. Annovi; W. Wiedenmann; E. Antipov; M. Antonelli; F. Anulli

2026-01-19https://doi.org/10.1007/jhep01(2026)117Journal of High Energy Physics 20261Optimizing Model Merging Configurations for Brazilian Portuguese Sentiment and Hate Speech Classification with TIES-Merging and SaDEViviane Galvão; Heder Bernardino

Brazilian Portuguese; Adaptation (eye); Sentiment analysis; Portuguese; Language model; Emotion detection; Speech processing; Computer science; Artificial intelligence; Machine learning; Natural language processing; Differential evolution

2026-01-01https://doi.org/10.1007/978-3-032-15990-8_21Lecture notes in computer science 20261Mobiliário urbano: abrigos para passageiros protegidos por desenho industrialO mobiliário urbano, no seu conjunto variado de exemplos, possui um papel importante no âmbito industrial e para a constituição da paisagem urbana. Este artigo tem por objetivo analisar o design de quatro abrigos para passageiros que possuem a proteção por desenho industrial. Metodologicamente foi realizada uma revisão narrativa de literatura e uma pesquisa exploratória no banco de dados do Instituto Nacional de Propriedade Industrial (INPI) para se identificar os abrigos para passageiros que possuem a proteção por desenho industrial. Verifica-se que os casos de referência possuem similaridades de projetos que primam pelas funções práticas do objeto. Conclui-se que a proteção por desenho industrial salvaguarda, valoriza e incentiva a prática profissional em alto nível.Danielle Lopes Vilas; A M Cruz Filho; Frederico BRAIDA

Work (physics); Context (archaeology); Field (mathematics); License; Business

2026-01-29https://doi.org/10.29147/datjournal.v10i3.1094DAT Journal 20261Formation of smectite from weathered Archean rocksJ.H. de Araújo; M.F. Ginani; F.A.B. de França; L.C. de Souza

Weathering; Archean; Clay minerals; Outcrop; Hydrothermal circulation; Parent rock; Geology; Geochemistry; Chemical composition; Mineralogy; Mineral; Greenstone belt

2026-01-31https://doi.org/10.1016/j.jsames.2026.105980Journal of South American Earth Sciences 20261METABOLIC SYNDROMEMetabolic syndrome (MS) constitutes one of the greatest challenges in global public health, characterized by a set of interrelated changes that substantially increase the risk of cardiovascular diseases, type 2 diabetes and mortality. It occurs especially in women, the elderly and individuals with low education. Such findings highlight structural inequalities that require an intersectional and interdisciplinary approach when formulating care strategies. This integrative review aimed to synthesize recent scientific evidence on the epidemiology, pathophysiological mechanisms and care and decision-making strategies related to MS. The search was carried out in June 2025 in the Scopus, PubMed, CINAHL, LILACS, SciELO, Google Scholar and Web of Science databases, using DeCS and MeSH descriptors, with a time frame from 2015 to 2025. Of the 1,238 studies initially identified, 10 met the inclusion criteria. The results showed a global prevalence of MS between 20% and 30%, with rates of 38.4% in the Brazilian adult population, especially in women, the elderly and individuals with low education. Studies have highlighted central mechanisms such as insulin resistance, chronic low-grade inflammation and endothelial dysfunction, in addition to serious clinical consequences. The need for multidisciplinary care models, cultural adaptation of clinical protocols and integration of digital technologies and artificial intelligence to optimize clinical decision-making and treatment personalization was also identified. It is concluded that tackling MS requires integrated interventions, robust public policies and investments in technological innovation, in addition to strengthening multidisciplinary care and the development of population-based preventive strategies.Sthélio Freitas Macedo; Shayene Thamalla Mendes dos Santos; Ana Paula Santos Resende; Milene Izabel Pezarini Jiacon; Joice Gomide Nolasco de Assis

Multidisciplinary approach; Metabolic syndrome; Personalization; Public health; Disease; Metabolic disease; Diabetes mellitus; Inclusion (mineral); Medicine; Gerontology; Set (abstract data type); Intensive care medicine; MEDLINE; Globalization; Type 2 diabetes; Type 2 Diabetes Mellitus; Health care

2026-01-31https://doi.org/10.51249/gei.v7i01.2824Revista Gênero e Interdisciplinaridade 20261A multiclass cost–latency aware framework for multi-tiered cloud storage optimization via access pattern forecastingEfficient management of cloud storage resources requires intelligent tier allocation strategies that balance cost optimization with performance requirements. While previous approaches have focused on binary classification schemes for storage tiering, real-world scenarios demand more granular solutions that can adapt to diverse user preferences and workload characteristics. This paper extends our previous work on access frequency prediction by proposing a comprehensive multiclass machine learning framework for intelligent cloud storage tiering. The proposed framework incorporates a novel three-tier classification system ( Cold / Warm / Hot ) and integrates user-centric preferences through a cost-weight parameter, enabling dynamic adaptation to varying preferences along the cost-latency spectrum. We demonstrate the framework’s effectiveness through extensive experiments on real-world access patterns, where we assess the performance of thirteen machine learning algorithms under various user preference profiles. The results show that our multiclass approach achieves cost reductions of up to 40% compared to a static tiering strategy, while providing Pareto-optimal solutions for different user profiles. Through comprehensive Pareto frontier analysis, we demonstrate the framework’s ability to provide transparent trade-off visualization, enabling informed decision-making for cloud storage administrators. Our main contributions are: a multiclass classification approach for storage tiering, the integration of user preferences via parameterized optimization, a comparative analysis of multiple algorithms across different preference configurations, and a practical validation of the framework’s applicability in production cloud storage environments.Flávio A.A. Motta; Saulo Moraes Villela; Heder Soares Bernardino; Glauber Dias Gonçalves; Alex Borges Vieira

Cloud computing; Cloud storage; Workload; Adaptation (eye); Benchmark (surveying); Resource allocation; Parameterized complexity; Multiclass classification; Computer science; Distributed computing; Machine learning; Pareto principle; Information repository; Resource (disambiguation); Database; Artificial intelligence; Computer data storage; Data mining; Resource management (computing); Binary number; Data access

2026-02-03https://doi.org/10.1016/j.comcom.2026.108437Computer Communications 20261Regulatory and Policy ConsiderationsFernanda Maria Policarpo Tonelli; Flávia Cristina Policarpo Tonelli; Joice Cristina de Paula; Iasmin Fernandes Emediato; Luiz Felipe Elver Santana Soares; Vinícius Marx Silva Delgado; Naony Sousa Costa Martins

Environmental remediation; Environmental policy; Pollution; Human health; Environmental pollution; Ecosystem; Environmental planning; Risk analysis (engineering); Business; Environmental resource management; Natural resource economics; Balance (ability); Environmental science

2026-01-01https://doi.org/10.1007/978-981-95-5743-1_10 20261A Hipocarbonic Binder Strategy Through the Reuse of Crushed Tempered GlassThe reuse of waste generated in various sectors has become a sustainable alternative. Advances in research highlight its potential as a secondary raw material to produce construction materials, contributing to the reduction in waste disposal while mitigating the intensive exploitation of natural resources. Tempered glass is rarely used in recycling and in the production of new materials. Therefore, this study evaluated the applicability of using it, after glass crushing, as a partial replacement for natural sand in the production of cement products. Thus, natural sand was replaced by 25% and 50% with sand resulting from glass crushing, and the mechanical properties (mechanical strength) and porosity (water absorption and void index) of the cementitious mixtures (mortars) were evaluated at 28 days, as well as their chemical properties and CO2 emissions. Glass powder (a result of crushing glass) was added to the mixtures to maximize the use of residual materials and improve the performance of the composite. The results demonstrate gains of approximately 10% in the studied properties with the substitution of natural sand with crushed tempered glass sand, and above 24% for the addition of glass powder, i.e., the addition of 20% powder glass tends to contribute favorably to the performance of cementitious mixtures, supporting the production of more sustainable building materials and making it an appropriate strategy for the circular economy.Maria Teresa Gomes Barbosa; Mayara Carelli de Paula Costa; Nelson Luís Gonçalves Dias de Souza

Reuse; Glass recycling; Cementitious; Raw material; Cement; Porosity; Natural stone; Absorption of water; Materials science; Waste management; Glass production; Composite material; Metallurgy; Flat glass; Environmental science; Void (composites); Building material

2026-02-02https://doi.org/10.3390/app16031483Applied Sciences 20261A metapsicologia do sadismo-masoquismo em Freud e a sua relação com as teorias pulsionaisEste trabalho propõe uma análise dos conceitos de sadismo e masoquismo nas obras de Freud, com o objetivo de evidenciar como a teoria do sadismo-masoquismo e as teorias pulsionais se articularam e se influenciaram mutuamente. Em sua primeira teoria pulsional, Freud relaciona o sadismo ao componente agressivo da pulsão que se tornou exacerbado e independente e que, por conta disso, dominou a tendência sexual do sujeito, enquanto o masoquismo é considerado uma continuação do sadismo que retornou contra a própria pessoa. Na segunda teoria das pulsões, com a introdução do conceito de pulsão de morte, a ênfase anteriormente dada ao sadismo recai sobre o masoquismo, agora considerado primário. O masoquismo corresponderia à parte da pulsão de morte que permaneceu no organismo ligada à libido, e o sadismo, parte dessa pulsão desviada aos objetos do mundo externo e posta a serviço da função sexual. Concluímos que não somente a introdução do conceito de pulsão de morte na obra de Freud implicou uma reformulação importante em sua teoria do sadomasoquismo, mas os próprios conceitos de sadismo e masoquismo também exerceram, de certo modo, uma influência na reformulação de sua teoria das pulsões.Renan Dutra da Cunha; Daniel Omar1939- Perez

Subject (documents); Meaning (existential); Perspective (graphical); Argument (complex analysis); Relation (database); Philosophy; Epistemology

2026-02-02https://doi.org/10.47456/sofia.v15i1.48567Sofia 20261O governo do 1° Visconde de Barbacenano Estado do Brasil: comunicação política,provimentos militares e redes de poder(1671-1675)O artigo analisa o governo de Afonso Furtado de Castro do Rio de Mendonça, 1º visconde de Barbacena, no Estado do Brasil (1671-1675), com foco na comunicação política interna e nos provimentos de serventias militares. Para analisar como a comunicação foi usada para estruturar as redes de poder e as negociações com elites locais utilizam-se fontes diversas como correspondências, provimentos, cartas patentes e consultas do conselho ultramarino. Metodologicamente o estudo combina análise quantitativa e qualitativa das correspondências e das serventias providas, para compreender os mecanismos de governação e as estratégias do visconde de Barbacena. A análise explora a interação entre a esfera política e militar, detalhando como a comunicação favoreceu tanto interesses particulares quanto as demandas do império português. Destacase a relevância de Afonso Furtado de Mendonça na articulação política atlântica, o uso estratégico de nomeações para consolidar redes de influência e os desafios de governar um território extenso e complexo. Conclui-se que a comunicação política foi central para consolidar o poder régio e gerenciar conflitos locais, revelando uma governança marcada por contínuas negociações.Hugo André Flores Fernandes Araújo

Government (linguistics); Governo; Power (physics); Order (exchange); Political science; Humanities

2026-01-30https://doi.org/10.19053/uptc.20275137.n32.2026.18713Historia y Memoria 20261No-local-broadcasting theorem for nonsignaling behaviors and assemblagesAdrian Solymos; Carlos H. S. Vieira; Cristhiano Duarte; Zoltán Zimborás

Set (abstract data type); Feature (linguistics); Sequence (biology); Algebra over a field; Mathematics; Pure mathematics; Computer science

2026-02-03https://doi.org/10.1103/q5gp-yjkdPhysical review. A/Physical review, A 20261P. Salgado - Psicologia da Revolução.pdfGustavo gabaldo

2026-01-01https://doi.org/10.48331/scielodata.gbgbhr/xdk0gjOpen MIND

20261P. Salgado - O que é o integralismo.pdfGustavo gabaldo

2026-01-01https://doi.org/10.48331/scielodata.gbgbhr/skhclrOpen MIND

20261O. de Faria - O Destino do Socialismo.pdfGustavo gabaldo

2026-01-01https://doi.org/10.48331/scielodata.gbgbhr/yotiuuOpen MIND

20261G. Barroso - História secreta do Brasil.pdfGustavo gabaldo

2026-01-01https://doi.org/10.48331/scielodata.gbgbhr/wu8aqjOpen MIND

20261G. Barroso - O integralismo de Norte a Sul.pdfGustavo gabaldo

2026-01-01https://doi.org/10.48331/scielodata.gbgbhr/sdkqshOpen MIND

20261O. de Faria - Cristo e César.pdfGustavo gabaldo

2026-01-01https://doi.org/10.48331/scielodata.gbgbhr/jq4bvzOpen MIND

20261P. Salgado - A doutrina do Sigma.pdfGustavo gabaldo

2026-01-01https://doi.org/10.48331/scielodata.gbgbhr/rvdbytOpen MIND

20261DESAFIOS NO DIAGNÓSTICO DE INFECÇÕES PADIÁTRICAS CONGÊNITAS: UM RELATO DE EXPERIÊNCIAINTRODUCTION: Stigmas and taboos surrounding sexually transmitted infections (STIs) hinder diagnosis and treatment, especially in cases of congenital transmission. During the pediatrics internship, challenges were encountered regarding misinformation and rejection of care, highlighting the importance of early diagnosis, a humanized approach, and combating prejudice through dialogue and public policies. REPORT: The student was responsible for the clinical evolution of some newborns at a maternity hospital during the pediatrics internship, while facing difficulties in dealing with the family’s refusal to accept the diagnosis, particularly when it came to STIs. This sometimes resulted in hospital evasion and interruption of the recommended treatment. DISCUSSION: The experience emphasized the importance of clinical practice in medical training, allowing the development of diagnostic, therapeutic, and socioemotional competencies. During the experience, the relevance of prenatal care in preventing severe outcomes was highlighted, particularly in terms of early diagnosis and the implementation of preventive interventions. The emotional impact on families, often intensified by the revelation of the diagnosis, reinforces the need for an empathetic and multidisciplinary approach. These actions aim to minimize complications, strengthen treatment adherence, and promote comprehensive care, ensuring not only clinical effectiveness but also the humanized quality of care. CONCLUSION: The experience provided both technical and biopsychosocial learning and highlighted the importance of integrating the emotional aspects of families in the management of congenital pediatric infections. In this context, it is essential to enhance the effectiveness of assertive and therapeutic communication by training the team to deal more effectively with cultural and emotional barriers. Additionally, it is necessary to strengthen psychosocial support, promoting more empathetic and humanized care to ensure treatment adherence and prevent hospital evasion.Sara Bezerra Motta Câmara; julia de Melo Gonçalves; Mariana Abreu Gandarela; Guilherme De Andrade Ruela

Misinformation; Psychosocial; Biopsychosocial model; Ignorance; Prejudice (legal term); Multidisciplinary approach; Relevance (law); Medicine; Nursing; Psychotherapist; Psychology

2026-02-02https://doi.org/10.53843/bms.v11i15.1013Brazilian Medical Students 20261P. Salgado - O Sofrimento Universal.pdfGustavo gabaldo

2026-01-01https://doi.org/10.48331/scielodata.gbgbhr/pv5kkzOpen MIND

20261Notas metodológicas - Gabaldo (Jan. 2026).pdfO texto tem como objetivo explicitar o percurso de pesquisa que deu origem ao artigo, detalhando as escolhas teóricas, analíticas e empíricas mobilizadas ao longo da investigação. A nota busca situar o trabalho no campo do pensamento político-social brasileiro, esclarecer os critérios de seleção das fontes, o recorte temporal adotado e os procedimentos de análise empregados, oferecendo ao leitor elementos para compreender como o argumento foi construído e em que tradições intelectuais e debates metodológicos ele se ancora.Gustavo gabaldo

Work (physics); Context (archaeology); Field (mathematics); Philosophy; Humanities

2026-01-01https://doi.org/10.48331/scielodata.gbgbhr/6dfjcwOpen MIND 20261O. de Faria - Maquiavel e o Brasil.pdfGustavo gabaldo

2026-01-01https://doi.org/10.48331/scielodata.gbgbhr/of19zgOpen MIND

20261G. Barroso - A Sinagoga Paulista.pdfGustavo gabaldo

2026-01-01https://doi.org/10.48331/scielodata.gbgbhr/kfrojhOpen MIND

20261Pesquisas em pensamento político-social brasileiro, o caso do antissemitismo entre intelectuais fascistas da década de 1930As Notas Metodológicas explicitam o percurso intelectual e analítico que deu origem ao artigo “As linguagens antissemitas dos intelectuais fascistas brasileiros (1931–1937)”, situando-o no campo do pensamento político-social brasileiro e em diálogo com abordagens interdisciplinares da história das ideias, da sociologia dos intelectuais e da teoria política. O texto parte da concepção do antissemitismo como linguagem política ou repertório semântico historicamente disponível, mobilizado por intelectuais afinados com cosmovisões fascistas no Brasil do entreguerras. O recorte empírico concentra-se no período 1931–1937, considerado o momento mais fecundo do pensamento fascista brasileiro, coincidindo com a produção dos principais ensaios políticos de Otávio de Faria, Plínio Salgado e Gustavo Barroso, bem como com a trajetória da Ação Integralista Brasileira até sua dissolução. A escolha desse intervalo permite analisar a circulação e a modulação das linguagens antissemitas sem avançar para as inflexões políticas do Estado Novo.Gustavo gabaldo

Field (mathematics); Experimental science; Philosophy

2026-02-03https://doi.org/10.48331/scielodata.gbgbhrOpen MIND 20261G. Barroso - O Integralismo em Marcha.pdfGustavo gabaldo

2026-01-01https://doi.org/10.48331/scielodata.gbgbhr/twfofiOpen MIND

20261P. Salgado - A Quarta Humanidade.pdfGustavo gabaldo

2026-01-01https://doi.org/10.48331/scielodata.gbgbhr/ruoyc2Open MIND

20261G. Barroso - Reflexões de um bode.pdfGustavo gabaldo

2026-01-01https://doi.org/10.48331/scielodata.gbgbhr/5sxmeqOpen MIND

20261G. Barroso - Judaísmo, maçonaria e comunismo.pdfGustavo gabaldo

2026-01-01https://doi.org/10.48331/scielodata.gbgbhr/gwrevyOpen MIND

20261G. Barroso - Brasil Colônia de Banqueiros.pdfGustavo gabaldo

2026-01-01https://doi.org/10.48331/scielodata.gbgbhr/93yswdOpen MIND

20261Read_me - Gabaldo (2026).docxGustavo gabaldo

2026-01-01https://doi.org/10.48331/scielodata.gbgbhr/lof5gyOpen MIND

20261P. Salgado - Páginas de combate.pdfGustavo gabaldo

2026-01-01https://doi.org/10.48331/scielodata.gbgbhr/dgiq8uOpen MIND

20261Challenges associated with the use of ChatGPT in health researchDear Editor, Vieira et al.() report titled “ChatGPT: immutable insertion in health research and researchers’ lives”, and Daungsupawong et al.() subsequent comments on that report consider the use of artificial intelligence (AI)—specifically ChatGPT—in health research, and discuss the advantages that this technology offers. Daungsupawong et al.() complement Vieira et al.() report by suggesting the association of new technological resources to expand the application of AI in health research. Both articles warn of potential errors and failures associated with the use [...]Marcos Henrique de Castro e Souza; Érika Mageste de Almeida Candido; Warley Oliveira Silva; Flávio Narciso de Carvalho; Maria Eduarda Finoti Alberice; Antônio Márcio Resende do Carmo

Complement (music); Public health; Health services; Digital health; MEDLINE; Key (lock); Health care; Public relations; Medicine; Political science

2026-01-01https://doi.org/10.31744/einstein_journal/2026ce1471Einstein (São Paulo) 20261Notas metodológicas - Gabaldo (Jan. 2026).pdfGustavo gabaldo

2026-01-01https://doi.org/10.48331/scielodata.gbgbhr/hxy83wSciELO - Scientific Electronic Library Online Dataverse

20261Quality-by-Design Compounding of Semisolids Using an Electronic Mortar and Pestle Device for Compounding Pharmacies: Uniformity, Stability, and CleaningBackground/Objectives: Manual preparation of semisolid formulations (creams, ointments, gels) is prone to variability in mixing energy and time, which may compromise uniform API distribution. This study aimed to evaluate an Electronic Mortar and Pestle (EMP; Unguator™) as a standardized compounding tool, with objectives to: (i) validate stability-indicating UHPLC methods; (ii) assess content uniformity across jar strata; (iii) quantify the impact of mixing time and rotation speed via design of experiments (DOE); and (iv) verify cleaning effectiveness and cross-contamination risk. Methods: Five representative formulations were compounded: urea 40%, clobetasol 0.05%, diclofenac 2.5% in hyaluronic acid 3% gel, urea 10% + salicylic acid 1%, and hydroquinone 5%. UHPLC methods were validated per ICH Q2(R2) and stress-tested under acid, base, oxidative, thermal, and UV conditions. Homogeneity was assessed by stratified sampling (top/middle/bottom). A 32 factorial DOE (time: 2/6/10 min; speed: 600/1500/2400 rpm) modeled effects on % label claim and RSD. Cleaning validation employed hydroquinone as a tracer, with swab sampling pre-/post-use and post-sanitization analyzed by HPLC. Results: All UHPLC methods met specificity, linearity, precision, accuracy, and sensitivity criteria and were stability-indicating (Rs ≥ 1.5). Formulations achieved 90–110% label claim with strata CV ≤ 5%. DOE revealed speed as the dominant factor for clobetasol, urea, and diclofenac, while time was more influential for salicylic acid; gels exhibited curvature, indicating diminishing returns at high rpm. Model-predicted optima were implementable on the Unguator™ with minor rounding of rpm/time. Cleaning validation confirmed post-sanitization residues below LOQ and <10 ppm acceptance. Conclusions: The Unguator™ provides a practical, parameter-controlled route for compounding pharmacies to standardize semisolid preparations, achieving reproducible layer-to-layer content uniformity within predefined criteria under the evaluated conditions through programmable set-points and validated cycles. DOE-derived rpm–time relationships define an operational design space within the studied ranges and support selection of implementable device settings and set-points. Importantly, the DOE-derived “optima” in this study are optimized for assay-based content uniformity (mean % label claim and strata variability). Cleaning validation supports a closed, low-cross-contamination workflow, facilitating consistent routines for both routine and complex formulations. Overall, the work implements selected QbD elements (QTPP—Quality Target Product Profile; CQA—Critical Quality Attribute definition; CPP—Critical Process Parameter identification; operational design space; and a proposed control strategy) and should be viewed as a step toward broader lifecycle QbD implementation in compounding.Hudson Polonini; Carolina Schettino Kegele; Savvas Koulouridas; Marcone Augusto Leal de Oliveira

Compounding; Factorial experiment; Hydroquinone; Mortar; Homogeneity (statistics); Mixing (physics); Materials science; Chromatography; Process engineering; Pulp and paper industry; Urea

2026-02-04https://doi.org/10.3390/pharmaceutics18020205Pharmaceutics 20261Read_me - Bolda(2026).docxGustavo gabaldo

2026-01-01https://doi.org/10.48331/scielodata.gbgbhr/yxul7sOpen MIND

20261Short-term inflation expectations evaluation in the presence of instabilitiesAbstract Modern macroeconomic theory and central bank practices have made expectations management a key ingredient in successful monetary policy. However, the challenge is greater in emerging economies, which are prone to instability and crises. Given that Brazil has frequently experienced major economic fluctuations, we study the behavior and forecasting performance of inflation expectations in a way that is robust to the presence of instabilities. The proposed tests provide more evidence against the rationality of the forecast for survey-based private forecasts. Furthermore, they uncover an informational or methodological advantage behind the medians of inflation expectations reported in the last five business days, and in forecasts in which the distance from the publication date of the observed IPCA prevails in relation to the projection time in the survey.Sidney M. Caetano; João H. G. Mazzeu

Inflation (cosmology); Rationality; Business cycle; Rational expectations; Position (finance); Emerging markets; Monetary policy; Economic stability; Economics; Econometrics; Monetary economics; Central bank; Projection (relational algebra); Relation (database); Deflation; Inflation targeting

2026-02-01https://doi.org/10.1007/s00181-025-02850-wEmpirical Economics 20261Brazilian version of the Fear of Falls Scale: translation, cross-cultural adaptation and validationAbstract Fear of falling can be present in the daily lives of patients with Parkinson's disease (PD) due to their predisposition to falls. The main objective of this study was to translate the Fear of Falls Scale (FFS) into Brazilian Portuguese, adapt it cross-culturally, and validate it. A multicenter, cross-sectional study was conducted with PD patients fluent in Brazilian Portuguese, recruited from five research centers in Brazil. Descriptive analysis characterized the sample and compared the data. Cronbach's α and McDonald's ω coefficients were used to assess the internal consistency of the scale. No significant differences were observed between the translated versions T1 and T2. The B1 and B2 versions did not present significant divergences in the back-translation from the original scale. The Movement Disorder Society – Unified Parkinson Disease Rating Scale (MDS-UPDRS) part III significantly correlated with motor skills (rho = 0.56, 0.43–0.67; p ≤ 0.001) and fear of falling (rho = 0.48, 0.34–0.60; p ≤ 0.001). Higher stages on the modified Hoehn & Yahr scale were associated with a greater decline in motor skills and a greater fear of falling (p < 0.001). The total internal consistency of balance-related motor skills and fear of falling was considered sufficiently reliable. Cronbach's α values were 0.96, 0.91, and 0.90; while McDonald's ω values were 0.96, 0.92, and 0.91, respectively. The Brazilian version of the FFS proved to be valid and reliable for assessing fear of falling in people with PD.Carla Marineli Saraiva do Amaral; A. da S. Gomes; Rafael Barbosa Mokdeci Surerus; Pedro Pigozzo Senra Lacerda; Vanessa Fernandes De Oliveira; Stephanie Suzanne de Oliveira Scott; Samuel Brito de Almeida; Walberto Silva dos Santos; Thiago Cardoso Vale; Fernanda Martins Maia Carvalho; Pedro Braga-Neto

Fear of falling; Internal consistency; Rating scale; Falling (accident); Scale (ratio); Consistency (knowledge bases); Poison control; Sample (material); Psychology; Physical medicine and rehabilitation; Clinical psychology

2026-01-01https://doi.org/10.1055/s-0045-1815738Arquivos de Neuro-Psiquiatria 20261Blood pressure and vascular responses during exercise in offspring of diabetes parents: The role of the muscle metaboreflexBACKGROUND: This study aimed to compare blood pressure and vascular responses during isometric handgrip exercise and muscle metaboreflex activation in the offspring of parents with type 2 diabetes and individuals without a family history of diabetes. METHODS: The sample consisted of a family history of type 2 diabetes parents (n = 12; 30.92 ± 4.87 years) and those without a family history of diabetes (n = 12; 28.42 ± 5.43 years). Blood pressure (Dixtal®), heart rate (ECG-Dixtal®) and muscle blood flow (Hokanson®) were recorded for 3 min at baseline and 3 min during isometric handgrip exercise (Saehan®). Immediately after the exercise, circulatory occlusion was performed for 2 min to assess muscle metaboreflex activation. Additionally, the vascular conductance was calculated. A two-factor repeated measures analysis of variance was conducted to test for possible differences between the groups for all variables under baseline conditions and during isometric handgrip exercise and to analyse the muscle metaboreflex activation. A significance level of p < 0.05 was adopted. RESULTS: Blood pressure, heart rate, muscle blood flow and vascular conductance showed similar baseline values in both groups, with significant and similar increases during the isometric handgrip exercise. Furthermore, for muscle metaboreflex activation, the systolic, diastolic and mean blood pressure values were significantly and similarly increased compared with baseline in both groups. CONCLUSIONS: The blood pressure and vascular responses during isometric handgrip exercise, as well as the muscle metaboreflex activation of blood pressure, are preserved in the offspring of parents with type 2 diabetes compared to those without a family history of diabetes.Aline Toledo de Oliveira; Tuany Mageste Limongi; Josária Ferraz Amaral; Lilian Pinto da Silva; Jefferson da Silva Novaes; Daniel Godoy Martinez; Mateus Camaroti Laterza

Blood pressure; Isometric exercise; Offspring; Diabetes mellitus; Hemodynamics; Vascular disease; Vascular smooth muscle; Medicine; Internal medicine; Cardiology; Endocrinology; Type 2 diabetes

2026-02-03https://doi.org/10.1111/cpf.70042Clinical Physiology and Functional Imaging 20261The Trajectory of Data-Driven Structural Health Monitoring: A Review from Traditional Methods to Deep Learning and Future Trends for Civil InfrastructuresStructural Health Monitoring (SHM) plays a critical role in ensuring the safety, integrity, longevity and economic efficiency of civil infrastructures. The field has undergone a profound transformation over the last few decad... | Find, read and cite all the research you need on Tech Science PressLUIZ Tadeu Dias Júnior; Rafaelle Piazzaroli Finotti; Flavio de Souza Barbosa; Alexandre Abrahão Cury

Structural health monitoring; Deep learning; Field (mathematics); Modal; Emerging technologies; Transformation (genetics); Artificial intelligence; Computer science; Data science; Engineering; Risk analysis (engineering); Big data; Trajectory

2026-01-01https://doi.org/10.32604/cmes.2026.075433Computer Modeling in Engineering & Sciences 20261Diversity and pathogen surveillance in chigger mites across Brazil's five biogeographic regionsThe expansion of land use in Brazil has caused biodiversity loss and increased human interaction with parasites and pathogens previously restricted to natural ecosystems. Chigger mites are ectoparasites during the larval stage and can cause skin reactions or transmit pathogens to their hosts, including humans. This study aimed to evaluate the diversity of chiggers collected from all five Brazilian biogeographical regions, along with pathogen surveillance. Specimens were subjected to both morphological taxonomy and endogenous control, followed by PCR assays targeting pathogens of the genera Borrelia, Orientia, and Rickettsia. The analyses revealed a high species richness, including two novel records in Brazil: the genus Boshkerria and the species Quadraseta antillarum. Additionally, the genus Quadraseta tested positive for Rickettsia sp., while tests for the other agents were negative. This is the first report of a Rickettsia sp. agent detected in a Quadraseta nymph.Isabella Pereira Pesenato; Ricardo Bassini-Silva; Ana Cláudia Calchi; Sueli Akemi Taniwaki Miyagi; Ester Nascimento da Costa; Carlos Cezar Trigo Nasser-Felix; Glauber Meneses Barboza de Oliveira; Maurício Cláudio Horta; Gabriela Cousandier; Jonas Sponchiado; Ralph Maturano; Graziela Tolesano-Pascoli; Renata Duarte Alquezar; Camile Lugarini; Ariane Ferreira; Luciano Moreira Lima; Erika Hingst-Zaher; Josivânia Soares Pereira; Darci Moraes Barros-Battesti; Marcelo B. Labruna; Fernando de Castro Jacinavicius

Biodiversity; Acari; Larva; Pathogen; Genus; Taxonomy (biology); Human pathogen; Biology; Zoology; Ecology; Arthropod; Transmission (telecommunications); Biological pest control; Rickettsia; Entomology

2026-02-06https://doi.org/10.1016/j.parint.2026.103248Parasitology International 20261Machine Learning-Driven Discovery of Indole/Oxoindole–Piperazine Scaffolds as Dual MAO-B/Sig-1R Ligands for Neurodegenerative DisordersThis study explores the dual modulation of monoamine oxidase B (MAO-B) and the Sigma-1 receptor (Sig-1R) as a promising multitarget strategy for central nervous system drug discovery. Robust QSAR-based machine learning models were developed using curated ChEMBL datasets, achieving high predictive performance and revealing key structural features associated with dual activity. Virtual screening of natural compounds identified candidates with multitarget potential, which were further validated by molecular docking and molecular dynamics simulations, establishing general SAR principles to support rational molecular design and lead prioritization in multitarget medicinal chemistry.Ulisses Candido da Silva; Miller Santos Ferreira; EDUARDO BORBA ALVES; Vieira Moura Paixão, Valéria; Igor Rodrigues Lapa; Micaela Marina Barbosa Nogueira; Rodrigues, Ricardo; Wanda P. Almeida; Marisi Gomes Soares; Daniela Aparecida Chagas‐Paula; Albert Katchborian Neto; Tiago Branquinho Oliveira; Danielle Ferreira Dias

chEMBL; Virtual screening; Drug discovery; Dual (grammatical number); Rational design; Prioritization; Key (lock); Drug; Computational biology; Chemistry; Computer science; Docking (animal); Neuroscience; Pharmacophore; Drug design; Monoamine oxidase

2026-03-05https://doi.org/10.5281/zenodo.18500367Open MIND 20261Educação Ambiental e Agroecologia: formação docente e diversidade pedagógicaEste artigo tem por objetivo dialogar sobre os fundamentos da Educação Ambiental e Agroecologia, mobilizando-os em experiências de formação docente e diversidade pedagógica, a partir de um projeto de pesquisa e extensão desenvolvido na Universidade Federal de Juiz de Fora (UFJF). Tendo em vista um modo de produção capitalista predatório, que acentua o pauperismo da classe trabalhadora e provoca o colapso socioambiental, torna-se essencial romper com a hegemonia do capital e a dominação do seu padrão de ser e estar, construindo caminhos para a diversidade de saberes, conhecimentos e formas de produzir a existência humana, referenciado nas demandas populares e nas reais necessidades humanas.Guilherme Goretti Rodrigues; Simone Ribeiro; Dileno Dustan Lucas de Souza

Diversity (politics); Capital (architecture); Context (archaeology); Work (physics); Linguistic diversity; Humanities; Political science; Sociology

2026-02-02https://doi.org/10.36661/2238-9717.2026n47.15285Fronteiras Revista Catarinense de História 20261Manual de Calouros: Instituto de Artes e Design da Universidade Federal de Juiz de Fora - 2026O Manual de Calouros – Instituto de Artes e Design da UFJF (2026) é um guia informativo produzido de forma independente para auxiliar estudantes ingressantes no Instituto de Artes e Design da Universidade Federal de Juiz de Fora. A publicação reúne orientações práticas sobre a chegada à universidade, circulação no campus, infraestrutura do IAD, serviços acadêmicos, sistemas institucionais, transporte, alimentação e oportunidades de vivência universitária. O conteúdo foi organizado a partir da experiência discente, com linguagem acessível e foco no uso cotidiano do campus. O manual inclui mapas, informações operacionais e referências úteis para facilitar a adaptação dos novos estudantes ao ambiente universitário e à dinâmica do curso, considerando procedimentos e serviços vigentes no ano de 2026. Esta obra integra a série Manuais de Calouros Independentes da UFJF e não possui vínculo institucional oficial com a universidade, tendo caráter informativo, educativo e de interesse público.João Pedro de Assis Almada; Jean Victor de Paula; Elis Gomes de Almeida Vieira; Nicole Ferreira Luiz; Thiago Henrique Martins Silva

Visibility; Work (physics); Critical discourse analysis; Process (computing); Political science; Humanities

2026-01-01https://doi.org/10.5281/zenodo.18489626Open MIND 20261Exploring stakeholder perceptions of peer support initiatives in the management of diabetes in low- and middle-income countries: An online survey studyPeer support is an effective strategy to promote self-management behaviors and improve well-being in those with cardiometabolic disease, including type 2 diabetes mellitus (T2DM). There is limited knowledge about stakeholder perceptions regarding peer support programs in low- and middle-income countries (LMICs). The study assessed stakeholders' awareness and understanding of peer support initiatives for T2DM, and explored their perceived barriers and readiness for implementation. A cross-sectional, self-administered online survey with branching logic was distributed to stakeholders across macro- (health policy), meso (tertiary hospital), and micro (community) levels of LMIC healthcare systems from June 1 to December 15, 2023. Quantitative data were analyzed descriptively; qualitative data underwent thematic content analysis. A total of 69 respondents from 25 LMICs participated in the survey. Due to branching logic and response attrition, 53 surveys (77%) had complete responses. Most respondents were medical doctors (n = 35, 50.7%) and a large proportion worked in tertiary hospitals (n = 27, 39.1%). Thirty-nine respondents (56.5%) were aware of peer support; among the 38 respondents with complete data, 29 (76%) reported active involvement in T2DM peer support initiatives. Of 15 responses to open-ended questionnaires regarding barriers to T2DM peer support, 9 (60%) cited concerns about limited resources and lack of funding. Local leadership (mean ± standard deviation: 3.4 ± 1.2), resource allocation (2.7 ± 1.4), and sustainability planning (2.7 ± 1.4) showed the highest perceived readiness on a 5-point Likert scale (1 = strongly disagree, 5 = strongly agree). Stakeholders in LMICs demonstrate awareness and active involvement in T2DM peer support programs. While limited resources and funding remain significant barriers, local leadership, resource allocation, and sustainability planning showed the highest perceived readiness, indicating promising foundations for implementation. Strengthening these areas through targeted support could facilitate the expansion and sustainability of peer support initiatives in resource-constrained settings.Bishal Gyawali; Soahum Bagchi; Zainab Atiyah Dakhil; Israa Fadhil Yaseen; Fathima Aaysha Cader; Lilian Pinto da Silva; Pooja Dewan; Diana Sherifali; Sheila Klassen

Stakeholder; Thematic analysis; Peer support; Likert scale; Perception; Sustainability; Survey data collection; Scale (ratio); Qualitative property; Medical education; Medicine; Psychology; Peer review; Health care; Qualitative research; Social support; Nursing; Knowledge management; Computer-assisted web interviewing

2026-02-05https://doi.org/10.1371/journal.pgph.0005840PLOS Global Public Health 20261Granular organic fertilizers from livestock waste via integrated UF-RO and granulation with soil performance evaluationThe production of granular organic fertilizers from dairy farming waste (cattle manure and dairy cattle wastewater) was evaluated. The wastewater was pretreated using ultrafiltration (UF) integrated to reverse osmosis (RO) to concentrate nutrients (nitrogen, phosphorus, and potassium) and to recover water, improving the sustainability of the process. The concentrated streams were incorporated into solid residues during the granulation process to produce granular fertilizers. The organic fertilizers were evaluated according to their nutrient release potential via soil column leaching tests, soil fertilization potential, as well as environmental (avoidance tests and greenhouse gas emission) and economic perspectives related to their uses. The increase in nutrient content in fertilizers enhances the feasibility of using these materials, as it decreases the required quantity for application and transport. The use of fertilizers formulated from UF concentrate contributes to a greater increase in organic matter in the soil, making them particularly suitable as soil conditioners. On the other hand, fertilizers produced from RO concentrate act primarily as nutrient sources, meeting the immediate needs of plants. Column leaching tests indicated that granular organic fertilizers enhanced nutrient retention in the upper soil layer (0–10 cm), limiting nutrient losses to deeper layers. Compared with incineration, soil application resulted in 32-fold lower GHG emissions (CO₂ and N₂O), corresponding to an approximate 97% reduction. Granular fertilizers also exhibited lower fertilization costs (US$0.26–0.45/ha), with ROc-based formulations being the most economical. Overall, the results demonstrate the technical, environmental, and economic feasibility of producing granular fertilizers from dairy cattle residues, supporting circular economy principles.Thais Girardi Carpanez; Livia M.C. Castro; Bruna L. Moreira; Julia B L S Carneiro; Eduarda V. S. Gomes; Fernanda R. C. Damasceno; Marcelo H. Otenio; Jonathas BG Silva; Julio Cézar Balarini; Miriam C.S. Amaral; Victor Rezende Moreira

Leaching (pedology); Nutrient; Granulation; Organic matter; Manure; Fertilizer; Soil organic matter; Soil conditioner; Greenhouse gas; Environmental science; Agronomy; Waste management; Environmental engineering; Biodegradable waste; Pulp and paper industry; Soil fertility; Organic fertilizer; Digestate

2026-02-05https://doi.org/10.1016/j.susmat.2026.e01908Sustainable materials and technologies 20261Heterogeneous stacking strategy for modeling flowing bottom-hole pressure of oil wellsAccurately predicting Flowing Bottom-Hole Pressure (FBHP) is critical for optimizing oil and gas production. Existing predictive methods often rely on oversimplified or complex, yet computationally expensive, models that fail to capture the intrinsic nonlinearities of well dynamics, leading to inaccurate predictions and potential economic losses. This paper introduces a three-layer heterogeneous stacking ensemble model to address the latter challenge. In particular, the key novelty of the developed work is a hierarchical architecture that integrates five distinct Machine Learning (ML) base learners, two meta-learners, and a final super-learner, i.e. , an additional meta-model that combines the outputs of the meta-learners to capture complex, non-linear relationships in the data. When evaluated on a field dataset (total dataset samples N = 795 ; test set samples N = 199 ), the proposed Super Learner Stacking model (ST-S) demonstrated superior predictive performance on the independent test set, achieving R-squared ( R 2 ) = 0 . 857 ± 0 . 006 and Root Mean Squared Error (RMSE) = 146 . 382 ± 2 . 806 . In addition, the ST-S model outperformed all individual models and simpler stacking ensembles reported in the article. As a result, the developed ST-S model provides a robust, data-driven tool for FBHP prediction, achieving high predictive accuracy without resorting to computationally expensive methods, thereby supporting improved well management and production optimization. • Accurate FBHP prediction using heterogeneous stacking ensemble • Super learner architecture improves FBHP prediction accuracy. • Ensemble outperforms individual models for oil well optimization. • Uncertainty analysis allows assessing model reliability and robustness. • Shapley analysis highlight key features influencing FBHP.Deivid Campos; Bruno da Silva Macêdo; Oscar Ikechukwu Ogali; Matteo Bodini; Dmitriy A. Martyushev; Farouk Al-Fahaidy; Camila Martins Saporetti; Leonardo Goliatt

Stacking; Set (abstract data type); Reliability (semiconductor); Ensemble forecasting; Field (mathematics); Test set; Benchmark (surveying); Ensemble learning; Key (lock); Computer science; Data mining; Machine learning; Work (physics); Predictive modelling; Component (thermodynamics); Artificial intelligence; Uncertainty quantification; Novelty; Algorithm; Test data

2026-02-05https://doi.org/10.1016/j.uncres.2026.100331Unconventional Resources 20261Systematic review of melatonin metabolism and circadian cycle regulation in the treatment of obesity and liver diseasesIntroduction: In the context of obesity and liver disease, sleep disorders are associated with several metabolic disorders, including insulin resistance, obesity, hypertension, fatty liver disease, and cardiometabolic complications. In this regard, melatonin (N-[2-(5-methoxy-1H-indol-3-yl)ethyl] acetamide) stands out. It is a neurohormone secreted by the pineal gland and plays a fundamental role in maintaining the circadian rhythm. Objective: To present the main considerations regarding the importance of melatonin and circadian regulation, as well as the effect of melatonin supplementation on obesity and liver disease. Methods: The systematic review guidelines of the PRISMA Platform were followed. The search was conducted from May to June 2025 across the Scopus, Embase, PubMed, and ScienceDirect, Scielo, and Google Scholar databases. Study quality was based on the GRADE instrument, and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: A total of 182 articles were found. A total of 58 articles were evaluated, and 51 were included in this systematic review. Using the Cochrane risk of bias tool, the overall assessment resulted in 15 studies with a high risk of bias and 21 studies that did not meet the GRADE criteria. Most studies presented homogeneous results, with X2=95.8%>50%. It was concluded that metabolic and liver diseases affect thousands of individuals worldwide, worsening quality of life and mainly compromising the productive period. Studies involving drug and molecular therapies are proposed to control the progression of these diseases. A molecular analysis involving epigenetic, biochemical, and inflammatory aspects related to melatonin supplementation is needed to clarify the effect of melatonin supplementation on obesity and liver diseases, including NAFLD and HCC. The elucidation of the antioxidant and antiinflammatory effect of melatonin and its use as a synergistic agent in weight loss, as well as in liver diseases, in personalized treatment, were highlighted.Francisco Alfredo Sampaio Cruz; Glauce Lippi de Oliveira; Isabele Helaine Rabelo Dias; Cristiano Villanova Andrade; Fernanda Assis Vianello Alvim; Pablo Wanglon Richter; Cristina Moraes Osório Leite; Leonardo Vieira Lima; Vaneska Carvalho Bezerra de Brito; F Durante

Melatonin; Circadian rhythm; Context (archaeology); Obesity; Systematic review; Pineal gland; Meta-analysis; Medicine; Endocrinology; Internal medicine; Bioinformatics; Fatty liver; Physiology

2026-02-04https://doi.org/10.54448/ijn26s102International Journal of Nutrology 20261Machine Learning-Driven Discovery of Indole/Oxoindole–Piperazine Scaffolds as Dual MAO-B/Sig-1R Ligands for Neurodegenerative DisordersThis study explores the dual modulation of monoamine oxidase B (MAO-B) and the Sigma-1 receptor (Sig-1R) as a promising multitarget strategy for central nervous system drug discovery. Robust QSAR-based machine learning models were developed using curated ChEMBL datasets, achieving high predictive performance and revealing key structural features associated with dual activity. Virtual screening of natural compounds identified candidates with multitarget potential, which were further validated by molecular docking and molecular dynamics simulations, establishing general SAR principles to support rational molecular design and lead prioritization in multitarget medicinal chemistry.Ulisses Candido da Silva; Miller Santos Ferreira; EDUARDO BORBA ALVES; Vieira Moura Paixão, Valéria; Igor Rodrigues Lapa; Micaela Marina Barbosa Nogueira; Rodrigues, Ricardo; Wanda P. Almeida; Marisi Gomes Soares; Daniela Aparecida Chagas‐Paula; Albert Katchborian Neto; Tiago Branquinho Oliveira; Danielle Ferreira Dias

2026-03-05https://doi.org/10.5281/zenodo.18500366Zenodo (CERN European Organization for Nuclear Research) 20261Manual de Calouros: Instituto de Artes e Design da Universidade Federal de Juiz de Fora - 2026O Manual de Calouros – Instituto de Artes e Design da UFJF (2026) é um guia informativo produzido de forma independente para auxiliar estudantes ingressantes no Instituto de Artes e Design da Universidade Federal de Juiz de Fora. A publicação reúne orientações práticas sobre a chegada à universidade, circulação no campus, infraestrutura do IAD, serviços acadêmicos, sistemas institucionais, transporte, alimentação e oportunidades de vivência universitária. O conteúdo foi organizado a partir da experiência discente, com linguagem acessível e foco no uso cotidiano do campus. O manual inclui mapas, informações operacionais e referências úteis para facilitar a adaptação dos novos estudantes ao ambiente universitário e à dinâmica do curso, considerando procedimentos e serviços vigentes no ano de 2026. Esta obra integra a série Manuais de Calouros Independentes da UFJF e não possui vínculo institucional oficial com a universidade, tendo caráter informativo, educativo e de interesse público.João Pedro de Assis Almada; Jean Victor de Paula; Elis Gomes de Almeida Vieira; Nicole Ferreira Luiz; Thiago Henrique Martins Silva

Visibility; Work (physics); Critical discourse analysis; Process (computing); Political science; Humanities

2026-01-01https://doi.org/10.5281/zenodo.18489625Zenodo (CERN European Organization for Nuclear Research) 20261Bridging the Simulation Gap: Physics-Interpretable Machine Learning Framework for In Silico Fatigue Life Prediction of Additively Manufactured PolymersRafael Meyer

Interpretability; Bridging (networking); Random forest; Process (computing); Curse of dimensionality; Support vector machine; Ensemble learning; Monte Carlo method; Ensemble forecasting; Machine learning; Artificial intelligence; Computer science; Uncertainty quantification; Inference; Surrogate model; Genetic programming; Design of experiments; Structured prediction; Feature selection; Statistical inference; Model selection

2026-02-05https://doi.org/10.21203/rs.3.rs-8735376/v1Research Square 20261Galleria mellonella pode ser comparada a modelos mamíferos para ensaios in vivo?Objetivo: Conduzir uma revisão sistemática sobre o uso de Galleria mellonella como modelo não mamífero para estudos in vivo e avaliar seu potencial como análogo a modelos mamíferos. Métodos: Esta revisão seguiu as diretrizes PRISMA, com a questão norteadora: “A G. mellonella pode ser utilizada como análogo a modelos mamíferos em ensaios biológicos?”, definida pela estratégia PICOs. As buscas foram realizadas no PubMed, MEDLINE Ovid, Scopus e Web of Science. Os critérios de inclusão foram estudos in vivo que realizaram os mesmos ensaios tanto em G. mellonella quanto em modelos mamíferos, publicados como artigos originais em inglês, português ou espanhol. Foram excluídos outros modelos de insetos e revisões. O risco de viés foi avaliado com a ferramenta SYRCLE modificada. Resultados: Sete estudos foram incluídos, investigando virulência, eficácia antimicrobiana e toxicidade em G. mellonella e em modelos mamíferos. Um estudo apresentou baixo risco de viés, cinco risco moderado e um risco alto. Foram observadas tendências comparáveis em virulência e eficácia de fármacos, embora a heterogeneidade metodológica tenha limitado comparações diretas. Conclusão: G. mellonella é um modelo pré-clínico valioso, mas não pode substituir integralmente os estudos em mamíferos. Seu melhor uso é como ferramenta preliminar de triagem, sendo necessárias pesquisas comparativas adicionais para validar sua relevância translacional. Palavras-chave: ensaios biológicos; grande traça da cera; modelo mamífero.Vitória Batista Clemente; Matheus Fernandes Lasneau Moraes; Taleessa Vieira Gomes; Amanda Marota de Oliveira; Mariana Simões de Oliveira; Ana Carolina Morais Apolônio

Galleria mellonella; Context (archaeology); Pyralidae; Variety (cybernetics); Scopus; Biology

2026-01-01https://doaj.org/article/89d2c79a127e4231a7d9bf73fe36fe66DOAJ (DOAJ: Directory of Open Access Journals) 20261Melatonin and treatment of patients with obesity and meta-inflammation: a meta-analysisIntroduction: According to the World Atlas of Obesity, overweight and obesity will affect nearly 3 billion adults (approximately 50% of the global adult population) by 2030. Melatonin therapy (MEL) and its pharmacological analogues are notable therapeutic agents for treating various pathologies, including obesity, metabolic diseases, and diabetes. Objective: A meta-analysis of melatonin therapy in the treatment of patients with obesity and meta-inflammation was conducted. Methods: The PRISMA systematic review guidelines were followed. Randomized clinical trials, prospective studies, and retrospective studies were included in the analysis. The literature search was conducted from July to August 2025 and was based on Web of Science, Scopus, Embase, PubMed, Lilacs, Ebsco, Scielo, and Google Scholar, covering scientific articles from various periods to the present. Results and Conclusion: Eighteen clinical studies with 4,678 participants were selected for this meta-analysis. According to the GRADE instrument, most studies presented homogeneous results, with X2=96.8%>50%. Considering the Cochrane risk of bias tool, the overall assessment resulted in 20 studies with a high risk of bias and 24 studies that did not meet the GRADE and AMSTAR-2 criteria. It was concluded that melatonin supplementation with an average of 5.0 mg significantly reduced body weight and reduced comorbidities in patients with obesity and meta-inflammation. Melatonin also regulates food intake, regulating the production and secretion of insulin, glucagon, and cortisol, and plays an important role in insulin signaling, with its deficiency having diabetogenic effects.Fernanda Assis Vianello Alvim; Francisco Alfredo Sampaio Cruz; Glauce Lippi de Oliveira; Isabele Helaine Rabelo Dias; Cristiano Villanova Andrade; Pablo Wanglon Richter; Cristina Moraes Osório Leite; Leonardo Vieira Lima; Vaneska Carvalho Bezerra de Brito; F Durante

Melatonin; Overweight; Obesity; Meta-analysis; Systematic review; Homogeneous; Prospective cohort study; MEDLINE; Medicine; Internal medicine; Endocrinology; Clinical trial; Affect (linguistics)

2026-02-05https://doi.org/10.54448/ijn26106International Journal of Nutrology 20261Colonização e Ensino de Design no Brasil: pesquisa-ação e experiências de decolonialidade no ensino da ModaEste artigo apresenta o percurso e os resultados do projeto Colonização e o Ensino de Design no Brasil – uma análise do currículo do curso de Design-Moda da Universidade Federal do Ceará (UFC), desenvolvido no âmbito do NAÏF – Núcleo de Estudos em Arte, Inovação, Moda e Design. A pesquisa, de caráter qualitativo e natureza de pesquisa-ação, utilizou a metodologia da narrativa de formação como dispositivo de reflexão crítica sobre o ensino de moda. Buscou-se compreender como a colonialidade do saber se manifesta nos currículos de cursos de design de moda e propor caminhos de decolonização a partir de práticas pedagógicas transformadoras. Entre os resultados destacam-se a publicação do Decolonial Zine: Fashion and Decoloniality in Brazil, em parceria com o Research Collective for Decoloniality and Fashion (Holanda), e a criação da disciplina Moda e Ativismo, que amplia o debate sobre diversidade, representatividade e epistemologias do Sul no campo da moda.Cyntia Tavares Marques de Queiroz; Michelle Medrado; Natalia Rosa Epaminondas

Decoloniality; Field (mathematics); Context (archaeology); Higher education; Problematization; Sociology; Philosophy; Humanities; Epistemology

2026-02-01https://doi.org/10.5965/259446301012026e8128Revista de Ensino em Artes Moda e Design 20261Efeitos agudos do exercício aeróbico com restrição de fluxo sanguíneo sobre a pressão arterial: uma revisão sistemáticaIntroduction: The acute effects of aerobic exercise with blood flow restriction (AE+BFR) on systolic, diastolic, and mean blood pressure remain scarce and inconsistent in the literature. Objective: To systematically review the acute effects of AE+BFR on systolic (SBP), diastolic (DBP), and mean blood pressure (MBP) in adults and older adults. Methods: Searches were conducted in October 2025 in PubMed, EMBASE, Cochrane Library, LILACS, Scopus, and gray literature. Randomized controlled trials comparing the acute effects of a single session of AE+BFR with conventional aerobic exercise (AE-C) on blood pressure were included. Two independent reviewers performed study selection, data extraction, and assessment of risk of bias (RoB 2) and certainty of evidence (GRADE). Results: Eight studies, totaling 130 participants, were included. The qualitative synthesis indicated that seven studies found no differences in SBP, DBP, or MBP after AE+BFR compared with AE-C. One study reported an increase in DBP immediately after AE+BFR (79.23 ± 10.56 vs. 69.69 ± 8.79 mmHg; p = 0.001). All studies showed some concerns regarding risk of bias, and the certainty of evidence was rated as very low for all three outcomes. Conclusions: Most studies indicate that AE+BFR does not acutely change SBP, DBP, or MBP compared with conventional aerobic exercise. However, the small number of studies, heterogeneity of protocols, and very low certainty of evidence suggest that the findings should be interpreted with caution.Susana América Ferreira; Pedro Ian Barbalho Gualberto; Luís Fernando Deresz; Diego Alves dos Santos; Ciro José Brito; Andréia Cristiane Carrenho Queiroz

Blood pressure; Aerobic exercise; Randomized controlled trial; Meta-analysis; Hemodynamics; Certainty; Diastole; Medicine; Internal medicine; Cardiology; Physical therapy; Myocardial infarction

2026-02-06https://doi.org/10.47197/retos.v76.118320Retos 20261Implementation Science in the Development of a Care Pathway for Chronic Chagas Disease: An Experience from a Municipality in Minas GeraisBACKGROUND: Chagas disease (CD) is a neglected endemic infectious disease. Primary health care (PHC) is responsible for delivering care to patients with CD in an integrated manner with other levels of the health system. We aimed to describe the use of implementation science (IS) as a tool for developing a care pathway for patients with CD from the perspective of the Brazilian Chronic Care Model (BCCM). METHODS: This study was conducted in the large municipality of Minas Gerais, Brazil. A diagnostic phase was conducted to identify barriers and facilitators related to CD care. The findings from this stage were analyzed using IS frameworks. Subsequently, the BCCM was adapted as a logical model to guide the creation of a care pathway. Health managers and professionals from the municipalities were trained to implement the proposed actions. After implementation, process and outcome indicators were monitored over a 12-month period. RESULTS: IS proved to be an effective strategy for applying BCCM to patients with CD in PHC settings. A total of 267 health professionals were trained. After the intervention, the following indicators increased: risk factor screening, serological testing, diagnosis, and antiparasitic treatment for CD. CONCLUSION: The development of a CD care pathway using IS tools integrated with the BCCM enabled the incorporation of processes into PHC and suggested that this model may be replicated in other contexts as well as for other chronic conditions requiring longitudinal care.Ana Carolina de Oliveira Gonçalves; Nayara Ragi Baldoni; Nayara Dornela Quintino; Wanessa Vinhal; Bruno Henrique Faria Melo; Sarah Rocha Dessimoni; Taise Aparecida Rodrigues Ferreira Santos; Katiuscia Francisca Ferreira Oliveira; Carlos Henrique Valente Moreira; Laura Marques Azevedo; Ariela Mota Ferreira; Ester Cerdeira Sabino; A L P R Ribeiro; Cláudia Di Lorenzo Oliveira; Maurílio de Souza Cazarim; Clareci Silva Cardoso

Chronic care; Care pathway; Chronic disease; Chagas disease; Critical pathways; MEDLINE; Nursing; Medicine; Environmental health

2026-01-01https://doi.org/10.1590/0037-8682-0381-2025Revista da Sociedade Brasileira de Medicina Tropical 20261“PORQUE EU FAÇO MATEMÁTICA DIFERENTE”O artigo aborda a educação matemática inclusiva e objetiva analisar a construção de territorialidades por estudantes com transtorno do espectro autista do Ensino Médio. A metodologia foi descritiva, de tipo qualitativo, e os dados foram produzidos por meio de oficina de mapas mentais e entrevistas semiestruturadas. A análise mostra a mobilização, pelos estudantes, de conhecimentos matemáticos diversos para a representação de espaços e relações na escola e sala de aula, bem como a redução das perspectivas do ensino da matemática às operações fundamentais. Conclui que a cartografia apresenta potencialidades para a educação matemática inclusiva.Mario Cleone de Souza; Fernanda Arçari Fachetti; Maria Gabriela Parenti Bicalho

Subject (documents); Active listening; Order (exchange); Period (music); Work (physics); Identity (music); Agency (philosophy); Pedagogy; Sociology; Psychology; Political science; Mathematics education; Linguistics; Epistemology

2026-01-30https://doi.org/10.30681/reps.v16i3.14011Eventos Pedagógicos 20261Elaboração e validação de protocolo clínico de enfermagem para dermatite associada à incontinência em pediatria*Objetivo: Elaborar e validar o conteúdo de um protocolo clínico de enfermagem para o tratamento de crianças com dermatite associada à incontinência com o uso adjuvante da laserterapia de baixa intensidade. Método: Estudo metodológico desenvolvido entre 2022 e 2024, através das etapas de revisão de literatura, construção e validação do protocolo clínico. Este protocolo foi estruturado em 10 tópicos a partir da recomendação das diretrizes metodológicas para elaboração de protocolos clínicos do Ministério da Saúde, avaliado por enfermeiros especialistas considerando os temas de clareza, coerência, relevância e completude. Resultados: Os conteúdos foram estruturados em torno do uso de fraldas descartáveis com trocas frequentes, uso de produtos adequados para a higiene e aplicação de produtos para a proteção da pele, conforme recomendados pela literatura, além do emprego da Laserterapia de Baixa Intensidade como tratamento adjuvante. O índice de validação de conteúdo para cada tópico verificado variou entre 91,6% e 100%. Conclusão: O protocolo clínico foi considerado válido para o tratamento de dermatites associadas à incontinência no contexto pediátrico.Gabriela Beims Gapski; J Girond; Jane Cristina Anders; Kelli Borges dos Santos; Anna Julia Trindade Bittencourt

Context (archaeology); Nursing care; Nursing process; MEDLINE; Medicine; Gynecology; Humanities

2026-02-01https://doaj.org/article/def583ce23fc4f9fb4842961beaa2b90DOAJ (DOAJ: Directory of Open Access Journals) 20261Fatores associados à resistência de docentes e discentes de cursos de Odontologia brasileiros frente à temática LGBTQIAPN+O objetivo deste estudo foi avaliar, em uma amostra de 156 coordenadores pedagógicos, as possíveis associações entre a resistência dos corpos docentes e/ou discente de cursos de Odontologia frente à temática LGBTQIAPN+ com o desenvolvimento de atividades curriculares distintas ao cuidado da saúde bucal da população LGBTQIAPN+ e com algumas características institucionais. Dentre as principais informações descobertas, duas se destacaram, sendo elas: em cenários acadêmicos resistentes à temática LGBTQIAPN+ predominaram os cursos de Odontologia que não desenvolveram atividades curriculares voltadas ao cuidado da saúde bucal de pessoas LGBTQIAPN+; os cursos de Odontologia privados foram os que mais prevaleceram entre os com presença e ausência de resistência junto à temática LGBTQIAPN+. Conclui-se que as informações levantadas neste estudo podem subsidiar futuras políticas públicas de atenção odontológica, educacionais inclusivas, voltadas à redução das iniquidades bucais experienciadas por essa população vulnerável.Mariana Alvim Fagundes; AC Paula; Mialhe Fl; Letícia Miquelitto GASPARONI; Mabel Miluska Suca Salas; Valéria de Oliveira; Werônica Jaernevay Silveira Mitterhofer; Carlos Botazzo; Luiz Eduardo de Almeida

Population; Work (physics); Qualitative research; Curriculum; Humanities; Sociology; Medical education

2026-02-07https://doi.org/10.30979/brazjdenteduc.v26.2439Brazilian Journal of Dental Education 20261Efficient protein precipitation approach driven by design of experiment for rapid lc–ms/ms quantification of β-lactam and quinolone residues in milkAbstract This work presents the development and validation of a rapid and selective method for the quantification of residues of β-lactam and quinolone antibiotics (Penicillin G, Oxacillin, Cloxacillin, Ceftiofur, Enrofloxacin, and Ciprofloxacin, using Dicloxacillin and Sarafloxacin as internal standards) in raw bovine milk. Twenty distinct sample preparation methods were evaluated using design of experiments (DOE), with the most efficient option involving a single step of protein precipitation using a mixture of organic solvents acetone/acetonitrile at a ratio of 75:25 (v/v), assisted by ultrasonic bath. After centrifugation, the supernatant was injected into an Ultra-performance Liquid Chromatography system coupled with Electrospray Ionization Triple Quadrupole Mass Spectrometry (UPLC-ESI-QqQ-MS/MS). The separation occurred in 4.5 min using a reversed-phase Acquity UPLC BEH C18 column (1.7 µm, 50 × 2.1 mm), with the mobile phase consisting of water with 0.1% formic acid and acetonitrile. Multiple Reaction Monitoring (MRM) acquisition mode was employed in MS for high sensitivity and selectivity. The method was validated in accordance with the criteria established by Commission Implementing Regulation (EU) 2021/808, indicating recoveries from 81.1 to 107.8%, with coefficients of variation below 9% for both repeatability and intralaboratory reproducibility, and trueness in the maximum residue limit (MRL) concentration level ranging from 96,9 to 108,7%. Linearity, selectivity, matrix effect, CCα, robustness, detection limits, and quantification limits (LoQ) were also evaluated, achieving LoQ values as low as 0.1 × MRL. The method was successfully applied to eight milk samples collected from tanks on commercial farms.Michelle Daiane de Almeida Loures; Marcelo Porto Bemquerer; Rafael Henrique Marques; Matheus Resende Nobre; Humberto de Mello Brandão; Marcone Augusto Leal de Oliveira

Protein precipitation; Formic acid; Detection limit; Repeatability; Mass spectrometry; Residue (chemistry); Sample preparation; Analyte; Selected reaction monitoring; Chromatography; Chemistry; Triple quadrupole mass spectrometer; Liquid chromatography–mass spectrometry; Electrospray ionization; Electrospray; Matrix (chemical analysis); High-performance liquid chromatography; Maximum Residue Limit; Quinolone

2026-02-07https://doi.org/10.1007/s11694-026-04045-yJournal of Food Measurement & Characterization 20261Three musketeers of Brazilian ethology: A tribute to César Ades, Werner Robert Schmidek, and Mateus José Rodrigues Paranhos da CostaArtur Andriolo; Gelson Genaro

Tribute; Pet therapy; HUBzero; Art; Humanities

2026-02-07https://doi.org/10.1016/j.applanim.2026.106952Applied Animal Behaviour Science 20261A Bayesian Meta‐Analysis of Renin−Angiotensin System Inhibitors Following TAVRBACKGROUND: Aortic stenosis leads to left ventricular remodeling, hypertrophy, and fibrosis, increasing the risk of heart failure. Renin-angiotensin system (RAS) inhibitors may mitigate these adverse effects and improve clinical outcomes. Despite advancements in transcatheter aortic valve replacement (TAVR), substantial mortality, heart failure readmissions, and other complications persist. AIMS: This study aimed to evaluate the impact of RAS inhibitor therapy following TAVR on clinical outcomes. METHODS: We conducted a systematic review and Bayesian meta-analysis following the Cochrane Handbook for Systematic Reviews of Interventions. A comprehensive search of PubMed, Embase, and Cochrane was performed to identify studies comparing RAS inhibitor (RASi) use versus non-use in patients undergoing TAVR for aortic stenosis. Odds ratios (OR) and 95% credible intervals (CrI) were estimated using a Bayesian random-effects model. Between-study heterogeneity was quantified using the posterior distribution of the heterogeneity parameter (τ). Posterior probabilities (PP) of treatment benefit were calculated, with clinically meaningful effects defined as P (OR < 0.8). All analyses were performed using R version 4.5.0. RESULTS: A total of 12 studies comprising 35,988 patients were included, of whom 17,026 (47.3%) received RASi therapy. The mean age ranged from 78.9 to 84.4 years. Post-TAVR RASi use was associated with a 79.4% probability of a clinically relevant reduction in all-cause mortality and a 99.5% probability of a clinically relevant reduction in cardiovascular mortality. There was a 54% probability of a clinically relevant reduction in heart failure hospitalization and a negligible (2.26%) probability of a reduction in the odds of myocardial infarction in the RASi group. CONCLUSIONS: RASi therapy following TAVR is associated with reduced odds of mortality and heart failure readmission.Vinícius Martins Rodrigues Oliveira; Lucas Barbosa; P Antonio Machado Gomes De Sousa; Ana Paula Duarte Lima; Masayuki Akabane; Arthur Borges; Edmundo Damiani Bertoli; Elísio Bulhões; Carlos Alexandre Farias; Roberto Mazetto; Paulo Roberto Ferreira Tartuce Filho; Robert Willian Anastácio Alcântara; Tiago Costa Bignoto; Brunna Pileggi; Humberto Graner Moreira; Ludimilla Tartuce

Odds; Bayesian probability; Heart failure; Odds ratio; Bayesian network; Medicine; Cardiology; Internal medicine; Intensive care medicine; Bayes' theorem; MEDLINE

2026-02-08https://doi.org/10.1002/ccd.70506Catheterization and Cardiovascular Interventions 20261Una psicología sin diván: Efectos de la práctica contemplativa sostenida del budismo tibetano sobre la neuroplasticidad y los procesos psicológicos. Una revisión sistemáticaAntecedentes: Las prácticas de meditación sostenidas o intensivas del budismo tibetano constituyen un sistema riguroso de entrenamiento mental y una sofisticada "psicología operativa". Si bien la evidencia empírica sugiere su capacidad para inducir transformaciones beneficiosas en procesos psicológicos y en el cerebro, no había sido sintetizada de manera integral y crítica. Objetivo: Analizar la evidencia empírica sobre los efectos de la meditación tibetana sostenida o intensiva en adultos, examinando procesos psicológicos clave (regulación emocional, control cognitivo, procesamiento autorreferencial, meta-conciencia) y sus correlatos de neuroplasticidad. Métodos: Se realizó una revisión sistemática conforme a los lineamientos PRISMA 2020 en cinco bases de datos (PubMed, PsycINFO, ERIC, SciELO, LILACS), identificando estudios empíricos sobre prácticas como śamatha, vipassana y métodos de compasión en contextos de experticia o retiros intensivos. Resultados: De 354 registros, se incluyeron 33 estudios. La síntesis reveló un patrón convergente organizado en tres dominios interconectados: 1) reconfiguración de la Red Neuronal por Defecto (menor activación y mayor conectividad con redes de control), 2) fortalecimiento del control cognitivo y atencional con mayor eficiencia neural, y 3) transformación de la regulación afectiva y cultivo de cualidades prosociales. Se documentaron cambios estructurales (ínsula, hipocampo) y funcionales que sustentan estas mejoras. Conclusión: Los hallazgos apoyan sólidamente que la meditación tibetana sostenida e intensiva actúa como un entrenamiento mental autoadministrado de alta eficacia, capaz de inducir una transformación neuropsicológica medible. La evidencia no solo sienta bases para su integración en marcos de salud psicológica, sino que valida su estatus como un sistema de desarrollo humano integral. Se requiere más investigación longitudinal para establecer trayectorias causales y explorar el papel de los métodos avanzados y del contexto filosófico-motivacional.Alberto Abad

Control (management); Behavioral therapy; Perceived control; Humanities; Psychology; Philosophy

2026-02-09https://doi.org/10.1590/scielopreprints.14711 20261Climate change, thermal comfort, and low-income residences: Insights from post-occupancy evaluations of concrete wall buildings in Brazil• Systematic review maps thermal comfort outcomes in Brazilian concrete wall housing. • Thermal discomfort reported across diverse climatic zones. • Only 13% of evaluated dwellings met acceptable comfort criteria. • Evidence gap: no studies in regions representing 76% of national territory. • First multi-climate study comparing thermal response and comfort in concrete-wall housing. The concrete wall construction system (CW) has gained prominence in Brazil, particularly in low-income residence projects, due to its high productivity. However, its thermal performance has been subject to scrutiny in a country with significant climatic diversity and increasing exposure to extreme weather. This systematic review analyzed Post-Occupancy Evaluations (POEs) focused on the thermal comfort of CW housing in Brazil. It revealed a scarcity of publications (only 19), most concentrated in the Southeast and South regions. No studies were identified in bioclimatic zones 1R, 3A, 4A, 5B, 6A, and 6B, which represent 76% of the territory. Only 3 case studies out of 23 (13%) in cold and mixed climates reported positive results above 80% satisfaction. Most POEs indicated negative comfort outcomes in extreme climates, with reports of discomfort during summer and winter. The lack of technical data and standardized methodologies compromise comparability. These findings reveal environmental, social, and health implications associated with the widespread adoption of CW systems, particularly for vulnerable populations. We conclude by highlighting the urgent need for research in underrepresented regions and for methodological standardization to support more reliable evaluations of thermal comfort and climate-related vulnerability as part of future impact assessment and housing policy analysis.Danielle Rios Garcia; Vítor Freitas Mendes; Clarice Fernandes Moraes; Maísa Maria Quintão Cabral; Iara Barbosa Andrade Rodrigues Silva; Júlia Castro Mendes

Thermal comfort; Vulnerability (computing); Climate change; Residence; Compromise; Built environment; Standardization; Environmental science; Scarcity; Environmental planning; Environmental resource management; Diversity (politics); Scrutiny; Cold climate

2026-02-01https://doi.org/10.1016/j.seta.2026.104847Sustainable Energy Technologies and Assessments 20261Elementos de custo a serem considerados em estimativas para estudos de microcusteio em terapia de diálise peritoneal (DP) na América LatinaResumo Introdução: As principais ferramentas para a tomada de decisões clínicas baseadas no uso eficiente de recursos são estudos de avaliação econômica que permitem avaliar tanto os custos quanto os benefícios de diferentes terapêuticas, com diretrizes adequadas para a elaboração de relatórios. Este estudo teve como objetivo desenvolver um checklist de elementos de custo de consumo a serem considerados em estimativas para estudos de microcusteio em diálise peritoneal (DP). Métodos: Foram trabalhadas quatro etapas, seguidas de análise e interpretação dos dados. Três etapas foram realizadas para o desenvolvimento do questionário de elementos de custo direto: 1ª – elaboração da primeira versão do checklist; 2ª – avaliação e expansão com a aplicação do método Delphi; 3ª – realização de dois painéis de especialistas; e 4ª – aplicação do questionário a profissionais de 18 países latino-americanos. Critérios de inclusão: profissionais com pelo menos um ano de experiência clínica e/ou administrativa em DP. Foi realizado um ajuste por distribuição de probabilidade discreta. Foram considerados lotes de distribuição por categoria de elementos de custo por país. Aplicou-se o método de estimação por máxima verossimilhança, e a classificação estatística dos ajustes foi estimada utilizando o Critério de Informação de Akaike. Resultados: Foram validados 596 questionários, com sete dimensões e 41 elementos. A partir dos resultados de cada lote, foi possível segmentar os elementos em três opções de escolha, com probabilidade de avaliar um elemento como muito importante, classificando assim os elementos de custo. Conclusão: O checklist favorece um dimensionamento econômico mais equitativo em estudos comparativos, possibilitando a comparação de valores econômicos em DP entre países, considerando os elementos de custo adequados.Celso Souza de Moraes- Júnior; Natalia Orihuela; Natália Maria da Silva Fernandes; Laura Cortés Sanabria; Luciane Senra de Souza Braga; Pablo Amair; Uriel Winik; Angelica Viviana Manchinelli; Marta Susana Adragna; Eliseo Antonio Guzmán; Cristina Vallve; Roger Ayala Ferrari; Rodrigo José Álvarez; Hernán Jaramillo Mendoza; Viviane Calice-Silva; Erwin I. Campos; Raúl Plata-Cornejo; Régulo Valdés; Ricardo Silvariño; Harold David Alvarez; Rosana Chaud; Alejandro Concepción Orozco; Gustavo Moretta; José Carolino Divino- Filho

Work (physics); Context (archaeology); Reliability (semiconductor); Computer science; Physics

2026-02-09https://doi.org/10.1590/2175-8239-jbn-2025-0202ptBrazilian Journal of Nephrology 20261The Use of Photovoice as a Teaching Strategy for Nursing Students: A Scoping ReviewBackground: University education has shifted from being professor-centered to student-centered, through the use of new methodological strategies, one of which is Photovoice, which can be especially useful for nursing students. Aims: Review the current evidence on the use of Photovoice as a teaching method for nursing students. Methods: A scoping review of articles published in peer-reviewed journals about use of Photovoice as an educational strategy was conducted using the databases PubMed, Scopus, Cumulative Index to Nursing and Allied Health Literature, PsycINFO, and Web of Science, with no restrictions on language or date of publication. From a total of 343 articles found in the search process, 18 were included for final analysis. Conclusion: Photovoice can be a valuable educational strategy for nurse students, particularly when a holistic student-centered approach that can elicit not only knowledge but also perceptions, attitudes, empathy, community sense, and skills is desired.Bárbara Badanta; María González-Cano-Caballero; Giancarlo Lucchetti; Rocío De Diego-Cordero

Photovoice; Nurse education; Nursing research; Nurse educator; Nursing literature; MEDLINE; Community health; Nursing; Medicine; Psychology; Medical education; Health education; Health care; Occupational health nursing

2026-02-09https://doi.org/10.1177/10784535261419563Creative Nursing 20261Cost elements to be considered in estimates for microcosting studies in peritoneal dialysis (PD) therapy in Latin AmericaINTRODUCTION: The main tools for making clinical decisions based on efficient use of resources are economic evaluation studies that allow the assessment of both the costs and benefits of different therapeutics, with appropriate guidelines for preparing reports. This study aimed to develop a checklist of consumable cost elements to be considered in estimates for micro-costing studies in peritoneal dialysis (PD). METHODS: Four stages were conducted, followed by data analysis and interpretation. Three stages were carried out to develop the direct cost elements questionnaire: 1st - designing the first version of the checklist; 2nd - evaluating and expanding it using the Delphi method; 3rd - conducting two expert panels; and 4th - applying the questionnaire to professionals from 18 Latin American countries. Inclusion criteria: professionals with at least one year of clinical and/or administrative experience in PD. A discrete probability distribution adjustment was performed. Distribution lots were considered according to the category of cost elements for each country. The maximum likelihood estimation method was applied, and the statistical classification of the adjustments was assessed using the Akaike Information Criterion. RESULTS: A total of 596 questionnaires, comprising seven dimensions and 41 elements, were validated. From the results of each batch, it was possible to segment the elements into three choice options, with the probability of evaluating an element as very important, thus allowing for the classification of the cost elements. CONCLUSION: The checklist favors more equitable economic dimensioning in comparative studies, making it possible to compare economic values in PD across countries, while considering the appropriate cost elements.Celso Souza de Moraes- Júnior; Natalia Orihuela; Natália Maria da Silva Fernandes; Laura Cortés Sanabria; Luciane Senra de Souza Braga; Pablo Amair; Uriel Winik; Angelica Viviana Manchinelli; Marta Susana Adragna; Eliseo Antonio Guzmán; Cristina Vallve; Roger Ayala Ferrari; Rodrigo José Álvarez; Hernán Jaramillo Mendoza; Viviane Calice-Silva; Erwin I. Campos; Raúl Plata-Cornejo; Régulo Valdés; Ricardo Silvariño; Harold David Alvarez; Rosana Chaud; Alejandro Concepción Orozco; Gustavo Moretta; José Carolino Divino- Filho

Latin Americans; Peritoneal dialysis; Checklist; Dimensioning; Health economics; Cost–benefit analysis; Cost effectiveness; Medicine; Intensive care medicine

2026-02-09https://doi.org/10.1590/2175-8239-jbn-2025-0202enBrazilian Journal of Nephrology 20261FITOTERÁPICOS E DESEMPENHO MUSCULAR: EVIDÊNCIAS RECENTES SOBRE GANHO DE MASSA E TESTOSTERONA EM HOMENS ATIVOSO uso de fitoterápicos como alternativa natural aos esteroides anabolizantes tem ganhado destaque no campo da nutrição esportiva, sendo impulsionado pela busca da melhora do desempenho físico e da composição corporal. No entanto, a eficácia e a segurança do uso dessas substâncias ainda necessitam de comprovação científica consistente. Este estudo teve como objetivo revisar as recentes evidências sobre os principais fitoterápicos comercializados visando o aumento da testosterona e da massa muscular, sendo eles Tribulus terrestres, Eurycoma longifólia, Withania somnifera, Mucuna pruriens, Fadogia agrestis e Bulbine natalenses. Trata-se de uma revisão sistemática da literatura realizada nas bases de dados “PubMed”, “Scopus”, “Web of Science” e “Google Acadêmico”. Foram selecionados 11 artigos, tanto em inglês quanto em português, considerando estudos do período entre janeiro de 2020 a outubro de 2025, com amostras compostas por homens jovens, saudáveis e fisicamente ativos. Os resultados indicaram que a Withania somnifera apresentou os efeitos mais consistentes, como redução do cortisol, melhora da força e da recuperação muscular, mas sem aumento significativo da testosterona. A Eurycoma longifólia demonstrou benefícios em relação ao bem-estar e o estresse, mas sem impacto hormonal relevante. Já Tribulus terrestres, Mucuna pruriens, Fadogia agrestis e Bulbine natalenses apresentaram eficácia limitada e riscos potenciais de toxicidade hepática e renal. Conclui-se que os estudos atuais ainda são bem limitados, não apresentando resultados significativos sobre o aumento da testosterona e ganho de massa muscular. Sendo assim, o uso dessas substâncias deve ser realizado com cautela e sob orientação profissionalNatalia Rodrigues dos Reis; Patrícia Rodrigues Ferreira; Tamara de Souza Jones; Thaynara Gonçalves de Souza; Vanessa Muniz Rosa

Withania somnifera; Letrozole; Caloric theory; Aromatase; Body weight; Weight gain; Medicine; Traditional medicine

2026-02-09https://doi.org/10.61164/e496na03Revista Multidisciplinar do Nordeste Mineiro 20261APPLE Study Protocol: Post-market Validation of the PreemieTest® Device for Neonatal Screening in Diverse Birth Scenarios — A Multicenter, Prospective Cohort StudyRoberta Lins Gonçalves; Sinval Sousa da Costa Neto; Daniele de Almeida Soares-Marangoni; Lysien I. Zambrano; Gabriela Silveira Neves; Alexandre Lopes Miralha; Abel Valente da Silva; Tainá Costa Pereira Lopes; Julie Andrez Ramos de Andrade Vieira; Amanda Valente da Silva; Ana Júlia Teixeira Costa; Evelyn Cristinne Costa Lima; Nayara Bezerra Bessa; Barbara Lira Bahia; PÉRSIDA GOMES DE SOUZA ROCHA; Francelio Silva de Sousa Júnior; Júlio Cesar Bertoso Lima; Hanna Lettícia Oliveira Lima; Roseany Cavalcante da Silva; Giovanna Dantas de Araújo; Ariany Estefany da Silva; Ana Carolina Aguirres Braga; Amanda de Oliveira Arguelho; Geovana Beatriz Pereira Mendes; Ellen Kathellen Sá de Souza; Iris Vicuña Julião Dias; Mariateresa Martines; Maria Luiza Kohatsu Arakaki; Géssy Cardoso Santos; Talita Cândida da Silva Almas Cabral; Gessilene Buzaglo Mori; Janderson Borges do Nascimento; Itzel Carolina Fuentes Barahona; Ana Michell Lopez; Ivan Espinoza; Eleonora Espinoza; Henry Castro; Héctor Manuel Carranza Coello; Amanda Resende Chagas; Scheila Tompai Marinho; Silvana Alves Pereira

Logistic regression; Usability; Concordance; Prospective cohort study; Cohort study; Missing data; Confounding; Cohort; Medicine; Protocol (science); Gestational age; Pediatrics; Pregnancy; Data collection; MEDLINE; Data quality; Emergency medicine

2026-02-09https://doi.org/10.21203/rs.3.rs-7521098/v1Research Square 20261Dataset on motor and functional skills and DatasetThis repository contains the supplementary materials of the study entitled “XXXXX”. The dataset includes raw and processed motor performance data assessed using the Movement Assessment Battery for Children – Second Edition (MABC-2) and the Pediatric Evaluation of Disability Inventory – Computer Adaptive Test (PEDI-CAT), as well as statistical analysis files and supporting documentation.Cristiani Junqueira; Guilherme Menezes Lage; Debora Miranda; nadia valentini; António Alvim-Soares; Lidiane Aparecida Fernandes

Raw data; Test (biology); Statistical analysis; Raw score; Movement assessment; Computerized adaptive testing; Computer science; Artificial intelligence; Data mining; Machine learning; Test data

2026-02-10https://doi.org/10.5281/zenodo.18603069Open MIND 20261A computational optimization approach to reduce emissions and fuel costs in waste collection servicesEffective solid waste management is essential for environmental protection and public health. Municipal Solid Waste (MSW) collection and transportation are crucial components of solid waste management, accounting for up to 80% of total resource allocation. These costs stem from labor expenses, high fuel consumption, and vehicle maintenance. Intensive vehicle usage during these stages leads to substantial energy consumption, atmospheric pollutant emissions, and urban congestion. Route planning offers a promising strategy for reducing costs and emissions associated with waste collection and transportation. Route optimization, also known as the Vehicle Routing Problem (VRP), provides a structured approach to route planning. This study aims to develop a computational model for optimizing waste collection and transportation routes for a small Brazilian municipality, Sapucaia. The proposed optimization problem is addressed using two tools: the Open Source Routing Machine (OSRM) and the Vehicle Routing Open-source Optimization Machine (VROOM). Furthermore, this study includes estimates of greenhouse gas emissions resulting from fuel combustion during waste collection and transportation. For this purpose, a GHG emissions calculation methodology based on the Brazilian GHG Protocol is adopted. The optimization results demonstrate a significant reduction in the total distance traveled. As a consequence of these shorter distances, fuel consumption is also reduced, leading to concomitant decreases in costs and CO 2 e emissions.Sara Crislei de Souza Soares; Vítor Fernandes Reis; Matteo Bodini; Nikolay O. Nikitin; Camila M. Saporetti; Leonardo Goliatt

Greenhouse gas; Fuel efficiency; Municipal solid waste; Waste collection; Vehicle routing problem; Total cost; Work (physics); Combustion; Waste management; Engineering; Environmental science; Environmental economics; Routing (electronic design automation); Resource (disambiguation)

2026-02-11https://doi.org/10.1016/j.latran.2026.100052Latin American Transport Studies 20261On the variation, distribution and evolutionary history of Myotis armiensis (Chiroptera, Vespertilionidae) along Neotropical mountain rangesAbstract Myotis armiensis was recently described from specimens collected in the mountain ranges of Costa Rica, Panama, and Ecuador. During a systematic revision of Neotropical Myotis , we identified additional specimens from Venezuela and Colombia. Using an integrative approach that combined morphological traits, cytochrome b sequences, and ecological niche modeling, we assessed the geographic variation of M. armiensis . Our findings indicate that this species can be structured into two allopatric populations: one in the Talamanca Cordillera of Central America, and another restricted to the South American Andes and Cordillera de La Costa in Venezuela. These populations are reciprocally monophyletic, exhibiting genetic distances greater than 3% and notable morphometric variation. The diversification of this taxon likely occurred during the Pleistocene, possibly driven by environmental fluctuations associated with glacial cycles. It is possible that M. armiensis comprises two recently diverged lineages, but future studies incorporating broader datasets are needed to properly assess the taxonomic status of these populations.Roberto Leonan M. Novaes; Marco Antônio Guimarães; Aldo Caccavo; Don E. Wilson; Marcelo Weksler; Ricardo Moratelli

Allopatric speciation; Taxon; Animal ecology; Morphometrics; Phylogeography; Niche; Biogeography; Glacial period; Taxonomy (biology); Biology; Ecology; Ecological niche; Environmental niche modelling; Diversification (marketing strategy); Range (aeronautics); Zoology

2026-02-10https://doi.org/10.1007/s42991-026-00563-wMammalian Biology 20261Dataset on motor and functional skills and DatasetThis repository contains the supplementary materials of the study entitled “XXXXX”. The dataset includes raw and processed motor performance data assessed using the Movement Assessment Battery for Children – Second Edition (MABC-2) and the Pediatric Evaluation of Disability Inventory – Computer Adaptive Test (PEDI-CAT), as well as statistical analysis files and supporting documentation.Cristiani Junqueira; Guilherme Menezes Lage; Debora Miranda; nadia valentini; António Alvim-Soares; Lidiane Aparecida Fernandes

Raw data; Test (biology); Statistical analysis; Raw score; Movement assessment; Computerized adaptive testing; Computer science; Artificial intelligence; Data mining; Machine learning; Test data

2026-02-10https://doi.org/10.5281/zenodo.18603070Zenodo (CERN European Organization for Nuclear Research) 20261AVALIAÇÃO DA ORALIDADE EM PESQUISAS NA FORMAÇÃO DE PROFESSORES: CONSIDERAÇÕES SOBRE CRITÉRIOS E ESTRATÉGIASNeste trabalho, analisamos os critérios e as estratégias de avaliação de gêneros orais em um conjunto de pesquisas realizadas com práticas de oralidade na formação docente. Para discussão teórica, retomamos as concepções de oralidade como prática social (Marcuschi, 2001), assim como perspectivas e critérios de avaliação em um viés processual, como parte da aprendizagem e do aperfeiçoamento dos alunos (Suassuna, 2007; Araújo; Suassuna, 2020). Como metodologia, realizamos uma pesquisa documental, em que 19 trabalhos (dissertações, teses e artigos) foram analisados a partir de um conjunto de cinco categorias para critérios de avaliação e sete estratégias avaliativas. Os dados revelam que, apesar da diversidade de critérios e estratégias avaliativas presentes na literatura, poucos são adotados na totalidade dos trabalhos. Como consequência, as práticas avaliativas de produção oral e as estratégias de avaliação necessitam de maior visibilidade e adoção pelos docentes, com vistas não só a explicitar aos graduandos questões a serem aperfeiçoadas na própria fala, como também repercutir na escola básica, na futura prática profissional desses licenciandos, como uma atividade fundamental para o desenvolvimento de estudantes.Rafaela das Dores Soares; TÂNIA GUEDES MAGALHÃES; Laís Lopes de Souza Gonçalves

Orality; Perspective (graphical); Subject (documents); Context (archaeology); Humanities; Philosophy

2026-01-26https://doi.org/10.26694/rles.v30i62.6778Linguagens Educação e Sociedade 20261MANEJO CIRÚRGICO DA OSTEONECROSE DOS MAXILARES ASSOCIADA AO USO DE BISFOSFONATOS: ABORDAGENS E DESAFIOS TERAPÊUTICOSA osteonecrose dos maxilares associada ao uso de bisfosfonatos representa uma condição clínica complexa, caracterizada por comprometimento do reparo ósseo e elevada morbidade. Apesar do predomínio histórico de abordagens conservadoras, o manejo cirúrgico tem sido progressivamente incorporado como estratégia terapêutica em casos refratários ou em estágios mais avançados da doença. O presente estudo teve como objetivo realizar uma revisão narrativa da literatura acerca do manejo cirúrgico da osteonecrose dos maxilares associada ao uso de bisfosfonatos, enfatizando as diferentes abordagens terapêuticas e os desafios clínicos envolvidos. A busca bibliográfica foi conduzida nas bases de dados PubMed/MEDLINE, SciELO e literatura científica internacional indexada, contemplando artigos publicados entre 2014 e 2024. Foram incluídos 20 estudos, entre revisões de literatura, séries de casos e relatos clínicos. A análise evidenciou ampla heterogeneidade quanto às técnicas cirúrgicas empregadas e ausência de protocolos padronizados, refletindo a natureza multifatorial da doença. Observou-se que a indicação cirúrgica deve ser individualizada, considerando a extensão da necrose, o estado sistêmico do paciente e a resposta ao tratamento conservador. O manejo adequado dos tecidos moles mostrou-se fator determinante para o sucesso terapêutico, enquanto as terapias adjuvantes apresentaram resultados promissores, porém sustentados por evidências limitadas. Conclui-se que o manejo cirúrgico constitui abordagem relevante no tratamento da osteonecrose dos maxilares associada aos bisfosfonatos, devendo ser pautado em avaliação criteriosa e abordagem multidisciplinar, enquanto novos estudos de maior robustez metodológica são necessários para a consolidação de diretrizes clínicas baseadas em evidências.Lúcio José Assis Da Silva; Reyglas Carvalho Moraes; Daiana Lisboa Bonfim; Aline Vieira Nascimento Priesnitz; Beatriz Bernardo Passos; Matheus Cunha Palouso; Adnaleila Silva de Medeiros Brandão; Rebeca Vidal Capelupi; Valeska Paulino Da Silva; Roberto Machado Cruz; Wilton Costa Neto; Thimóteo de Almeida Barbosa; Fernanda scharf; Elcivan Ferreira De Oliveira Júnior; Rafael Veloso Rebello; Alex França da Silva; Marcelo Vitale; Letícia Luana Moreira Da Silva; Paulo Cecílio De Oliveira Júnior; Paulo Cesar Ulson De Souza; Vitória Valeska Silva Nascimento; Lara Marques Motta; Otávio Henrique da Silva Leal; Antonio Francisco Costa; Ana Júlia Toledo Tavares

Disease; Chemotherapy; Context (archaeology); Medicine; Gynecology

2026-02-10https://doi.org/10.56238/levv17n57-028LUMEN ET VIRTUS 20261Milk Kefir Beverage Improves Histomorphometry, Reduces Inflammatory Infiltrates and Desulfovibrio and Increases Lactobacillus in IL‐10 −/− MiceABSTRACT This study aimed to evaluate the effects of milk kefir on parameters related to inflammatory bowel disease (IBD) in interleukin‐10 knockout (IL‐10 −/− ) mice. Sixteen C57BL/6J IL‐10 −/− male mice were divided into two experimental groups. The control group ( n = 8) received 0.4 mL of whole milk (UHT) and the kefir group ( n = 8) received 0.4 mL of a fermented beverage made from milk kefir grains (2.4 × 10 8 colony‐forming units [CFU]), both administered via gavage for 4 weeks. Feces were collected and body weight was measured weekly. At the end of the study, the animals were anesthetized and euthanized, and the small intestine and cecum content were collected for analysis. Proximate composition of kefir and microbiological analysis were conducted. Histomorphometry measurements and quantification of short‐chain fatty acids (SCFAs) were conducted in small intestine. SFCAs were also evaluated in cecum content, and microbiota composition was evaluated in fecal samples. The kefir beverage improved histomorphometry characteristics of the small intestine, increased the number of goblet cells, reduced inflammatory infiltrates, increased Lactobacillus , and reduced Desulfovibrio , suggesting attenuation of the inflammatory process. Furthermore, the kefir beverage increased the concentration of butyrate, a short‐chain fatty acid with anti‐inflammatory properties, in the small intestine, which may also be associated with reduced inflammation in this group.Iasmim Xisto Campos; Vinicius Fernandes Paris; Mariana de Fátima Albuquerque Pereira; Gabriela de Cássia Ávila Alpino; Andressa Ladeira Bernardes; Larissa Gabriela Morais de Ávila; Marcella Duarte Villas Mishima; Manoela Maciel dos Santos Dias; Soraya Torres Gaze Jangola; Tiago Mendes; Maria do Carmo Gouveia Pelúzio

Kefir; Cecum; Feces; Small intestine; Inflammation; Fermentation; Inflammatory bowel disease; Composition (language); Food science; Medicine; Chemistry; Lactic acid; Fatty acid; Short-chain fatty acid

2026-02-01https://doi.org/10.1111/1750-3841.70879Journal of Food Science 20261Videoteca digital sobre o uso de máscara para a população brasileira: construção, validação e avaliaçãoObjetivo: Desenvolver uma videoteca digital sobre o uso de máscara para a população brasileira. Método: Estudo metodológico desenvolvido em 2021 e 2022, nas seguintes etapas: busca dos temas, estudo teórico, elaboração dos vídeos, validação dos vídeos por especialistas, adequação após validação, avaliação do público-alvo, adequação após avaliação do público-alvo e disponibilização. Utilizou-se o programa Powtoon® para a construção dos vídeos e o Video Software Development Company para a edição. Adotou-se o Índice de Concordância com mínimo de 0,7. Resultados: A videoteca digital foi desenvolvida e composta por nove vídeos explicativos. Validada por 12 especialistas, apresentou Índice de Concordância médio global de 1,0. Na avaliação por 15 representantes do público-alvo, a videoteca obteve resultados satisfatórios em todos os aspectos. Considerações finais: Desenvolvida como uma inovadora tecnologia educacional para disseminar informações sobre o uso de máscaras pela população na pandemia, a videoteca digital foi considerada adequada por especialistas e representantes do público-alvo.Hevelyn dos Santos da Rocha; Milena Cristina Couto Guedes; Natália Maria Vieira Pereira Caldeira; Fernanda Garcia Bezerra Góes; Maithê de Carvalho e Lemos Goulart; Jennifer Costa Sales Honorato; Fernanda Maria Vieira Pereira- Ávila

Digital signal; Software; Work (physics); Context (archaeology); Humanities; Philosophy; Computer science

2026-02-05https://doi.org/10.19175/recom.v16i0.5630Revista de Enfermagem do Centro-Oeste Mineiro 20261Epidemiological and clinical profile of respiratory viral infections in 2021: integrated surveillance during the COVID-19 pandemicBackground The COVID-19 pandemic disrupted the seasonality and detection patterns of other respiratory viruses, complicating syndromic surveillance and clinical management in several regions, including Brazil.Objectives To describe the epidemiological, clinical and hospitalization profiles of patients with laboratory-confirmed respiratory viral infections diagnosed in 2021, comparing SARS-CoV-2 variants, influenza B, respiratory syncytial virus (RSV), human rhinovirus (HRV) and negative cases.Methods We conducted a retrospective analysis of molecular diagnostic results and clinical – epidemiological data from 337 patients/samples. Analyses included logistic regression to estimate odds ratios (ORs) for risk factors and principal component analysis (PCA) to explore symptom clustering.Findings SARS-CoV-2 (Gamma variant), HRV, RSV and influenza B were the most frequently detected viruses. PCA revealed virus-specific symptom clusters, with notable overlap among pathogens. Compared with Delta, Gamma showed higher clinical severity (OR ~ 3.0; CI95%: 1.21–7.32). Diabetes and obesity were significantly associated with COVID-19. Coinfections were infrequent and not linked to greater severity.Main conclusions Findings support integrated respiratory surveillance using multiplex PCR in sentinel settings, variant-aware clinical screening and timely genomic characterization to guide care pathways and inform local public health actions.Katia Ozanic; Aripuanã Sakurada Aranha Watanabe; Antônio Charlys da Costa; Vanessa Galdeno Freitas; Eva Maria de Assis de Carvalho; Vanessa Cordeiro Dias; Vânia Lúcia da Silva; ALESSANDRA BARBOSA FERREIRA MACHADO; Cláudio Galuppo Diniz

Epidemiology; Pandemic; Respiratory system; Epidemiological surveillance; Coronavirus disease 2019 (COVID-19); Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); 2019-20 coronavirus outbreak; Medicine; Virology; Intensive care medicine; Respiratory tract infections; Pneumonia; Coronavirus; Pandemic influenza

2026-01-02https://doi.org/10.1080/17460794.2026.2624957Future Virology 20261Dataset for ER/NR discrimination in CYGNO via machine learningThis dataset contains the hybrid data (Monte Carlo + Real Noise) used for ER/NR discrimination analysis. Files description:1. features_data.csv: - Contains extracted features for Classical ML models. - Label column: 'particle_type' (0 for ER, 1 for NR, 2 for Noise). 2. images_data.h5: - Contains the pre-processed sCMOS images for Deep Learning models (cropped to 224x224). - The data is already split into training and testing sets to ensure reproducibility. - Internal Structure (HDF5 groups/datasets): * 'train_images': (N_train, 224, 224, 1) - float32 array of cropped event images for training. * 'train_labels': (N_train,) - int32 array of labels for training. * 'test_images': (N_test, 224, 224, 1) - float32 array of cropped event images for testing. * 'test_labels': (N_test,) - int32 array of labels for testing. * Attribute 'class_names': encoded list of class names corresponding to the labels. 3. split_indices.json: - Contains the indices used to divide data into Train and Test sets. - Keys: 'train', 'test'.Luan Gomes Mattosinhos de Carvalho

Event (particle physics); Class (philosophy); Pattern recognition (psychology); Training set; Deep learning; Test data; Noisy data; Artificial intelligence; Computer science; Machine learning

2026-02-12https://doi.org/10.5281/zenodo.18624068Zenodo (CERN European Organization for Nuclear Research) 20261Information needs about peripheral arterial disease: Perspectives from healthcare providers, health students, and patientsCarolina Machado de Melo Felix; Gabriela Lima de Melo Ghisi; Lílian Pinto da Silva; Bárbara de Cássia Dias Fagundes; Camila Kümmel Duarte; Marcella Guimarães Assis; Danielle Aparecida Gomes Pereira

Information needs; Arterial disease; Peripheral; Health care; Health information; MEDLINE; Medicine; Intensive care medicine; Medical emergency; Needs assessment; Information system

2026-02-12https://doi.org/10.1016/j.jvn.2026.01.005Journal of Vascular Nursing 20261Formulation of Tryptanthrin incorporated in Pluronic-based copolymers aiming biomedical purposesBruno H. Vilsinski; Ana Flávia dos Santos Fuzaro; Maria de Paula Rodrigues; Thais de Souza Oliveira; Frederico Silva; Jacy Gameiro; Richard Michael Grazul; M. de Almeida; Wilson Braz; Caroline R. Bender; Julia Eduarda Spode; Paulo de Souza

Micelle; Cytotoxicity; Bioavailability; Copolymer; Drug delivery; Viability assay; Natural product; Solubilization; Aqueous solution; Chemistry; Combinatorial chemistry; Nanotechnology; Solubility; Materials science; Nanoparticle; Drug carrier; In vitro; Aqueous medium

2026-01-01https://doi.org/10.2139/ssrn.6221289SSRN Electronic Journal 20261Dataset - privateDescription pending.Luan Gomes Mattosinhos de Carvalho

2026-02-12https://doi.org/10.5281/zenodo.18624067Zenodo (CERN European Organization for Nuclear Research)

20261A APLICAÇÃO DA REALIDADE VIRTUAL COMO ESTRATÉGIA PEDAGÓGICA VOLTADA AO APRIMORAMENTO DO RACIOCÍNIO CLÍNICO EM PSIQUIATRIA E SAÚDE MENTAL: REVISÃO ESCOPOOBJETIVO: Mapear e analisar as evidências mais atuais sobre a aplicação da Realidade Virtual (VR) como estratégia pedagógica voltada ao aprimoramento do raciocínio clínico em psiquiatria e saúde mental, identificando tipos de intervenções, contextos educacionais, resultados de aprendizagem e lacunas na produção científica. MÉTODOS: Revisão de escopo, realizada entre dezembro de 2025 a janeiro de 2026, conduzida conforme as recomendações metodológicas do Instituto Joanna Briggs e orientada pelo checklist PRISMA-ScR, com protocolo registrado na Open Science Framework. A pergunta norteadora foi formulada a partir do mnemônico PCC: P – estudantes e profissionais da área da saúde; C – aplicação da VR como estratégia pedagógica; C – ensino em psiquiatria e saúde mental. Foram incluídos estudos completos, de acesso livre, publicados nos últimos cinco anos, em todos os idiomas, que abordassem o uso da VR em contextos educacionais voltados à psiquiatria e saúde mental. Excluíram-se estudos fora do contexto educacional ou que não discutissem a VR com finalidade pedagógica. As buscas foram realizadas nas bases PubMed, Medline, Scopus, Embase e Cochrane Library, com busca complementar no Google Acadêmico. A seleção e extração dos dados foram conduzidas por dois revisores independentes. RESULTADOS E DISCUSSÃO: Foram incluídos 12 estudos, com predomínio de revisões sistemáticas, metanálises e ensaios controlados, majoritariamente desenvolvidos em cursos de graduação em enfermagem e medicina. As intervenções concentraram-se no uso de VR imersiva, pacientes virtuais interativos e pacientes padronizados virtuais, aplicados principalmente em ambientes acadêmicos simulados. Os resultados apontam melhora consistente do raciocínio clínico, da competência percebida, das habilidades comunicacionais e da empatia, especialmente quando associados a debriefing estruturado e possibilidade de repetição dos cenários. Observou-se heterogeneidade metodológica, predomínio de avaliações de curto prazo e limitada investigação sobre transferência do aprendizado para a prática clínica real. CONCLUSÃO: A VR configura-se como estratégia pedagógica promissora para o aprimoramento do raciocínio clínico em psiquiatria e saúde mental, sobretudo quando integrada a desenhos pedagógicos robustos. Apesar dos benefícios observados, persistem lacunas relacionadas à avaliação longitudinal dos efeitos, à diversidade de contextos educacionais e à padronização metodológica, indicando a necessidade de pesquisas futuras que avaliem impactos sustentados na prática profissional.Nelson Pinto Gomes; Sadi Antonio Pezzi Junior; Elisabete Soares de Santana; Pedro Ernesto Teles Barbosa; Adna Lopes Ferreira Xavier; Ana Clara Netto Armando Fiche; Thaís Ribeiro de Moura; Ana Carolina Gottardi Wilhelm; Heloisa Ribeiro Borges; Mônica Beatriz Ferreira; Carlos Lopatiuk; Renata Trindade Gonçalves

Checklist; Internship; Perception; Context (archaeology); Psychology; Applied psychology; Humanities; Medical education

2026-02-09https://doi.org/10.18623/rvd.v23.n4.4518Veredas do Direito Direito Ambiental e Desenvolvimento Sustentável 20261MITIGATION OF DIAGNOSTIC UNCERTAINTY IN PSYCHIATRY AND MENTAL HEALTH IN PRIMARY CARE: A SCOPING REVIEWOBJECTIVE: To map and analyze recent scientific evidence on the mitigation of diagnostic uncertainty in psychiatry as a core element of clinical decision-making in primary mental health care, identifying diagnostic strategies, care practices, and organizational approaches. METHODS: Scoping review conducted between December 2025 and January 2026, following Joanna Briggs Institute recommendations and reported according to PRISMA-ScR. The research question was structured using the PCC framework. Studies published in the last five years, in any language, addressing diagnostic uncertainty in primary mental health care were included. Searches were performed in PubMed, Medline, Scopus, Embase, and Cochrane Library, with complementary searches in Google Scholar. Data selection and extraction were performed independently by two reviewers. RESULTS AND DISCUSSION: Twelve studies were included. Findings indicate that mitigating diagnostic uncertainty relies on integrating diagnostic tools, collaborative and measurement-based care practices, and organizational strategies. Care practices predominated, while organizational interventions were less frequently addressed, highlighting important gaps. CONCLUSION: Reducing diagnostic uncertainty in primary mental health care requires sustained, integrated strategies combining longitudinal follow-up, structured communication, standardized assessment tools, and collaborative care models to improve clinical decision-making and diagnostic safety.Nelson Pinto Gomes; Sadi Antonio Pezzi Junior; Elisabete Soares de Santana; BEATRIZ SOUZA LEAL; Alexandre Edu Rassy; João Vitor Gomes Braga; Milena Fernandes da Silveira; Daniel Gomes Fialho; Ticiano Magalhães Dantas; Pedro Ernesto Teles Barbosa; Islandia Maria Rodrigues Silva; João Paulo Lopes da Silva; Renata Trindade Gonçalves

Mental health; Psychological intervention; Primary care; MEDLINE; Data extraction; Mental health care; Health care; Medicine; Nursing; Primary health care; Collaborative Care; Psychology; Psychiatry; Integrated care; Diagnostic test

2026-02-11https://doi.org/10.18623/rvd.v23.n4.4838Veredas do Direito Direito Ambiental e Desenvolvimento Sustentável 20261Machine learning for bead geometry prediction in 5083-H112 aluminum laser welding considering a challenging datasetLaser welding of 5083-H112 aluminum alloy presents several challenges due to the material’s high reflectivity and thermal conductivity. Consequently, it becomes difficult to establish a processing window that properly associates parameters with the desired weld bead geometry. This study aims to analyze and compare the predictive performance of five widely used machine learning regression techniques (Support Vector Regression, Decision Trees, Random Forest, K-Nearest Neighbors, and Artificial Neural Networks) for estimating weald bead geometry, considering a challenging dataset. It has small size, high process variance, and a discontinuity corresponding to the conduction-to-keyhole transition, thereby providing an important benchmark for assessing the models' capability of calibration on limited datasets. Weld bead width and penetration depth were selected as outputs, while scanning speed and power as inputs. A total of 99 bead-on-plate experiments were performed by combining 11 levels of laser power (1000 to 4600 W) and three levels of scanning speed (0.5, 1.0, and 4.0 m/min), within each parameter combination, process repeatability was accessed. The dataset was split into training (80%) and testing (20%) subsets. The best hyperparameters for each machine learning technique were determined by using GridSearch and five-fold cross-validation. The K-Nearest Neighbors technique resulted as the most recommended due to its low mean absolute percentage error, 4.68% for width and 8.35% for penetration depth, combined with the generation of smoother curves for physical plausibility. Feature importance analysis highlighted laser power as predominant factor. The proposed techniques demonstrate strong potential for industrial implementation, specially assisting technical personnel in defining process windows. • Comparison of five ML regression techniques for aluminum laser welding; • Challenging dataset with low repeatability and discontinuities; • KNN achieved low MAPE and produced smoother weld bead predictions; • Laser power identified as the dominant factor in weld bead geometry; • ML techniques show strong potential for industrial real-time implementation.Luiz Eduardo dos Santos Paes; J I Andrade; Carlos Antonio Ribeiro Duarte; André Alves de Resende; Rafael de Oliveira Teloli; João Marcos Souza Dias; Julián Arnaldo Ávila; Moisés Luiz Lagares; Leonardo Rosa Ribeiro da Silva; Tiago Vieira da Cunha; Elisan dos Santos Magalhães; Ivan Francisco Vieira Filho; Gustavo Henrique Truppel; Milton Pereira

Hyperparameter; Laser power scaling; Welding; Support vector machine; Repeatability; Artificial neural network; Metrology; Laser beam welding; Surface metrology; Materials science; Machine learning; Artificial intelligence; Mechanical engineering; Calibration; Computer science; Power (physics); Laser; Process window; Benchmark (surveying); Process (computing); Penetration depth; Gaussian process

2026-02-13https://doi.org/10.1016/j.jmrt.2026.02.084Journal of Materials Research and Technology 20261Comparação de Três Versões do Modelo de Sel’kovNo presente trabalho, apresentamos três versões do modelo de Sel’kov(1968 [8]). A versão clássica, usado para descrever oscilações glicolíticas, uma versão em derivada fracionária de Caputo, dada em [6], que foi usada para descrever fenômenos microssísmicos e nossa proposta em derivadas fracionárias baseado na técnica apresentado em [4] e [5] onde teremos o operador de Riemann-Liouville presente no modelo. Usando o método numérico L1, apresentaremos uma comparação das três formas do modelo de Sel’kov exibindo as soluções, trajetórias de fase e pontos de equilíbrio.Sandro R. Mazorche; Esther S. M. Gonçalves; Tiago F. C. Santos

Context (archaeology); Term (time); Function (biology); Humanities; Philosophy

2026-02-13https://doi.org/10.5540/03.2026.012.01.0265Proceeding Series of the Brazilian Society of Computational and Applied Mathematics 20261Desafios da Impressão em Filamento ABS em Impressoras 3D de Baixo CustoA manufatura aditiva tem revolucionado a produção de materiais em diversas áreas, incluindo design, engenharia, educação e saúde. O presente estudo está inserido no âmbito do pro jeto de extensão LabMaker Multidisciplinar: Tecnologias 3D para Diversas Áreas, da Universidade Federal de Juiz de Fora (UFJF), que visa difundir a cultura maker em escolas, além de atender de mandas internas, como a produção de modelos anatômicos para o ensino na área da saúde. Dentre os modelos produzidos, destacam-se as pelves impressas em 3D, desenvolvidas a partir de tomografias computadorizadas, processadas em softwares especializados para a posterior impressão. O material usado foi o ABS (acrilonitrila butadieno estireno), escolhido por sua resistência comparada a outros tipos de filamentos. Contudo, devido ao uso de impressoras de baixo custo e sem compartimento fechado, a impressão em ABS apresentou desafios relacionados à variação térmica, resultando no fenômeno de delaminação. Este trabalho visa propor uma solução para viabilizar a utilização deste filamento em impressoras abertas utilizando uma cobertura feita em papelão, buscando mitigar os erros que podem ocorrer durante o processo de impressão. Para isso, foram realizados testes de impressão com e sem a cobertura e com porcentagens de preenchimento distintas. Ao final, foram comparadas as qualidades das impressões e discutida a eficiência da cobertura em papelão.Ewerson S. Rodrigues; M.H.A. Ribeiro; Camilla M. Calil; Alessandreia Marta de Oliveira; Flávia S. Bastos

Humanities; Physics

2026-02-13https://doi.org/10.5540/03.2026.012.01.0272Proceeding Series of the Brazilian Society of Computational and Applied Mathematics 20261Olimpíada MirimO intuito deste trabalho é discutir a importância da realização da Olimpíada Mirim nos anos iniciais do Ensino Fundamental I, para que os alunos possam, desde pequenos, estabelecer um relacionamento mais próximo com a Matemática e desenvolver cada vez mais o seu pensamento lógico-racional. Além disso, pretende-se debater os desafios encontrados durante a aplicação da prova, bem como os benefícios decorrentes da participação dos alunos nas provas.Isabela M. Moreira; Letícia S. Costa; Samir J. Copar; Joana D. A. S. da Cruz; Flaviana A. Ribeiro; Sandro R. Mazorche

Work (physics); Theme (computing); Scope (computer science); Order (exchange); Subject (documents); Philosophy; Psychology

2026-02-13https://doi.org/10.5540/03.2026.012.01.0321Proceeding Series of the Brazilian Society of Computational and Applied Mathematics 20261Calendário da Caravana da MatemáticaA Caravana da Matemática é um projeto de extensão que promove a popularização da Matemática presencialmente nas escolas de Juiz de Fora e região e virtualmente pelas redes sociais. Uma das ações do projeto é a publicação do Calendário da Caravana da Matemática, um calendário publicado no formato de posts diários nas redes sociais do projeto, que traz curiosidades e fatos matemáticos sempre relacionados ao número ordinal do dia do ano. Nesse trabalho, apresentamos essa experiência de divulgação Matemática, refletindo sobre sua produção e seu impacto junto ao público do projeto e também na formação dos discentes envolvidos.Beatriz Motta; Reginaldo Braz; Sandro Rodrigues Mazorche; Nelson Louza; Sara Santos; Thales Marciano

Representation (politics); Context (archaeology); Work (physics); Humanities

2026-02-13https://doi.org/10.5540/03.2026.012.01.0258Proceeding Series of the Brazilian Society of Computational and Applied Mathematics 20261Medical students’ mental health, quality of life, motivation, and learning approaches before, during and after COVID-19: findings from a 4-wave repeated cross-sectional surveyThis study examined changes in mental health, quality of life, academic motivation, and learning approaches before, during, and after the COVID-19, pandemic. The secondary objectives included identifying factors associated with these outcomes and investigating the mediating role of motivation in the relationship between learning approaches and mental health. This repeated cross-sectional survey included four distinct cohorts of medical students (n = 1,860) assessed in 2016, 2018, 2020, and 2022. Mental health (DASS-21), quality of life (WHOQOL-BREF), academic motivation (Academic Motivation Scale), and learning approaches (Revised Two-Factor Study Process Questionnaire) were used. Analyses included ANOVA, linear regression, and mediation models. While no significant differences in mental health were observed across cohorts, a positive trend emerged during the COVID-19 period, marked by increased deep learning, reduced surface learning, and higher scores in physical and environmental QoL compared with the other three non-COVID time points. Further, motivation was found to be higher during the COVID time point than in the pre-COVID (2018) period. The COVID-19 differences were further supported by linear regression, which showed that sex, age, income, ethnicity, stage of medical training, and study hours were associated with at least one of the assessed outcomes. Mediation models offered the additional insight that surface learning may increase amotivation, which, in turn, may result in worse mental health, whereas deep learning may have suppressive mediation. These findings underscore the importance of learning approaches in shaping motivation and mental health of medical students, showing that even in vulnerable situations, deeper learning approaches can minimize mental distress.Maria do Carmo Mattos Martins; Giancarlo Lucchetti; João Pedro Torres Neiva Rodrigues; Raquel Vieira Torres; Mariana Brandão Sampaio; Isadora de Cássia Oliveira Leal; Vitória Mesquita Campos Mendes; Jéssica Aparecida Gomes Cotta; Natalia Castro Pecci Maddalena; Alessandra Lamas Granero Lucchetti

Mental health; Mediation; Quality (philosophy); Repeated measures design; Affect (linguistics); Structural equation modeling; Psychology; Clinical psychology; Applied psychology; Developmental psychology; Quality of life (healthcare)

2026-02-13https://doi.org/10.1080/13548506.2026.2623309Psychology Health & Medicine 20261Traveling Waves for the Newtonian Foam Displacement in Porous MediaThis work presents an analytical study of three partial differential equations systems that describe foam flow models in porous media. The first two models consider the surfactant concentration fixed above the critical micellar concentration: First Order Kinetic model and a simplified version of the Stochastic Bubble Population balance model. A significant difference between these models is the influence of critical water saturation in the first model. The third model generalizes the second by varying the surfactant concentration and considering gas mobility that depends on the surfactant concentration. We study the traveling wave solutions of such systems using phase portrait analysis. All obtained analytical solutions are confirmed using direct numerical simulations of the system of partial differential equations. The second model is validated with experimental data.Rosmery V. Q. Zavala; Luis F. Lozano; Grigori Chapiro

Porous medium; Partial differential equation; Work (physics); Bubble; Traveling wave; Displacement (psychology); Pulmonary surfactant; Saturation (graph theory); Mechanics; Materials science; Newtonian fluid; Non-Newtonian fluid; Thermodynamics; Population; Flow (mathematics); Mathematics; Physics; Differential equation; Porosity; Mathematical analysis; Critical speed

2026-02-13https://doi.org/10.5540/03.2026.012.01.0342Proceeding Series of the Brazilian Society of Computational and Applied Mathematics 20261Solução do problema de Riemann descrevendo o deslocamento de espuma com adsorção aplicado à indústria de petróleoMotivados pelo deslocamento de espuma em meios porosos com adsorção linear, estendemos trabalhos já existentes para o escoamento bifásico contendo um traçador ativo descrito por um sistema de leis de conservação não estritamente hiperbólico. Classificamos as soluções no plano de fase contendo todos os possíveis estados à esquerda e à direita conectados por uma sequência de ondas compatíveis. Destacamos que existem regiões de parâmetros onde mais de uma sequência de ondas compatíveis ocorre. Mostramos que o modelo implementado no CMG-STARS, descrevendo o deslocamento de espuma em meios porosos com adsorção, satisfaz as propriedades necessárias para aplicar a teoria desenvolvida. Apresentamos regiões de parâmetros onde o modelo do CMG-STARS possui uma falta de unicidade da solução no plano de fase, levando a uma perda de estabilidade estrutural. Mostramos também que este modelo é bem-posto no sentido de Hadamard, podendo apresentar oscilações devido à perda de estabilidade estrutural. Descrevemos o bando de surfactante como uma sequência de dois problemas de Riemann, determinamos cenários onde a espuma apresenta um melhor desempenho e avaliamos o impacto da adsorção.Giulia C. Fritis; Pavel S. Paz; Luis F. Lozano; Grigori Chapiro

Firth; Heading (navigation); Work (physics)

2026-02-13https://doi.org/10.5540/03.2026.012.01.0337Proceeding Series of the Brazilian Society of Computational and Applied Mathematics 20261Simulação Computacional do Deslocamento de Espuma Considerando a Adsorção de SurfactanteEste trabalho estuda numericamente a influência da adsorção de surfactante em escoamentos bifásicos líquido-gás em meios porosos heterogêneos. Neste contexto, um modelo de espuma em equilíbrio local é adotado e a espuma é tratada como um fluido não-Newtoniano. Incluindo os efeitos do surfactante na fase líquida e levando em conta os efeitos de adsorção cinética e em equilíbrio do surfactante, uma formulação de fluxo fracionário baseada na pressão global é utilizada, resultando em um sistema que acopla o problema de Darcy com as equações do transporte para as saturações de fluido e concentração de surfactante. Essas equações são divididas em dois subsistemas que são resolvidos por um algoritmo numérico sequencial que combina um método híbrido de elementos finitos para aproximar o sistema de Darcy com um método de volumes finitos de alta ordem para encontrar as saturações de fluido e concentração de surfactante. Um método de diferenças finitas implícitas é adotado para a discretização no tempo e os problemas hidrodinâmico e hiperbólico são resolvidos usando um algoritmo escalonado em diferentes escalas de tempo. Os resultados numéricos mostram o impacto negativo dos efeitos de adsorção na eficiência de varredura do gás em escoamentos bifásicos em meios porosos heterogêneos.Filipe F. de Paula; Iury Igreja; Grigori Chapiro

Work (physics); Data flow model; Unsteady flow; Flow (mathematics); Physics; Humanities

2026-02-13https://doi.org/10.5540/03.2026.012.01.0335Proceeding Series of the Brazilian Society of Computational and Applied Mathematics 20261AUTOPERCEPÇÃO POSITIVA DE SAÚDE E FATORES ASSOCIADOS EM IDOSOS COM DOENÇAS CRÔNICAS EM BELO HORIZONTE: VIGITEL 2019 E 2020Objetivo: Descrever e comparar a autopercepção positiva de saúde e fatores associados em idosos com diabetes e/ou hipertensão, entre janeiro e dezembro de 2019 e, janeiro a abril de 2020. Métodos: Estudo observacional do tipo transversal repetido com dados do Vigitel de Belo Horizonte, Minas Gerais. Realizou-se regressão logística binária para estimar efeitos das variáveis sobre a autopercepção. Resultados: Em 2019 e 2020, a amostra constituiu-se de (n=623) e (n=314) idosos, respectivamente. Não houve diferença estatisticamente significativa nas proporções de autopercepções positivas entre os períodos. Observou-se diferenças estatisticamente significativas entre autopercepção positiva e fatores associados: histórico de tabagismo (ß2019= 0,137; ß2020= -0,420), consumo de frutas e hortaliças (ß2019= 0,438; ß2020= -0,084), tempo de tela (ß2019= 0,326; ß2020= -0,069), tabagismo (ß2019= -0,207; ß2020= 0,500), consumo de álcool (ß2019= -0,338; ß2020= 0,224) e baixo peso (ß2019=-0,131; ß2020= 0,201. Conclusão: A autopercepção positiva de saúde relacionou-se à adoção de comportamentos protetores à saúde. Palavras-chave: saúde do idoso; doenças não transmissíveis; Autoavaliação; covid-19; inquéritos populacionais.Samara Moreira de Paula Paiva; Ronaldo Rocha Bastos

Observational study; Epidemiology; Cross-sectional study; Public health; Population; Medicine; Gynecology; Gerontology

2026-02-12https://doi.org/10.59788/resp.v4i1.237Revista de Epidemiologia e Saúde Pública - RESP 20261Modeling Nanoparticle-Stabilized Foam Flow in Porous MediaFoam injection with nanoparticles can be useful in various subsurface applications, particularly in challenging field conditions such as oil production in the Brazilian Pre-Salt. By enhancing foam stabilization, nanoparticles improve their effectiveness as mobility-control agents in gas flooding. We propose new models of nanoparticle-stabilized foam flow in porous media, accounting for nanoparticle transport and its effect on reducing foam mobility. The first model considers foam at local equilibrium and is governed by a non-strictly hyperbolic system of conservation laws. The existence and uniqueness of a global solution as a sequence of waves are proved using entropy conditions. The analytical solution is utilized to evaluate the impact of nanoparticles on key industrial parameters such as breakthrough time, water production, and pressure drop over time. We also perform sensitivity analysis and uncertainty quantification studies. The second and more complex model accounts for particle retention and permeability reduction. In this case, a steady-state semi-analytical solution is presented. It is then used to investigate the impact of nanoparticle retention on water saturation, foam’s apparent viscosity, and pressure drop profiles. We also discuss two opposing effects of retention on pressure drop and how models that neglect one or both of these effects underestimate pressure.Tatiana D. Assis; Grigori Chapiro

Porous medium; Enhanced oil recovery; Pressure drop; Nanofluid; Nanoparticle; Permeability (electromagnetism); Porosity; Uniqueness; Materials science; Mechanics; Petroleum engineering; Drop (telecommunication); Entropy (arrow of time); Relative permeability; Conservation of mass; Flow (mathematics); Fluid dynamics

2026-02-13https://doi.org/10.5540/03.2026.012.01.0313Proceeding Series of the Brazilian Society of Computational and Applied Mathematics 20261Engagement strategies for people living with leprosy: a scoping review of studies published from 1992 to 2024BACKGROUND: Leprosy is an infectious disease that can cause permanent deformities if untreated. Stigmatization contributes to treatment abandonment and social exclusion. Engaging patients and families may improve health outcomes. This scoping review mapped studies on engagement strategies for people with leprosy. METHODS: Database searches were conducted up to February 2025, including original studies that addressed engagement strategies for individuals with leprosy, as well as their families and communities. Terms related to “leprosy” and “health behavior” guided the search in EMBASE, Scopus, BVS/Lilacs, Medline/PubMed, and Web of Science. Independent selection and data extraction were conducted and strategies synthesized using the adapted 6W4H tool. They were classified into five engagement levels: Inform about health, Inform about engagement, Empower, Partner and Integrate. RESULTS: Eighteen studies published between 1992 and 2024 were included. The identified strategies consisted prevention of disability (POD) interventions (n = 3; 16.67%), mobile applications for health education and leprosy case detection (n = 2; 11.11%), self-help groups (SHG) (n = 2; 11.11%), self-care group (SCG)(n = 1; 5.76%), community project to improve attitudes towards leprosy (n = 1; 5.76%), lesson plans for health education on leprosy (n = 1; 5.76%), community project to reduce stigma related to leprosy (n = 1; 5.76%), face-to-face meetings between people with leprosy and the general public (n = 1; 5.76%), text messages for monitoring pharmacological treatment of leprosy patients (n = 1; 5.76%), self-care education program (n = 1; 5.76%), educational podcast (n = 1; 5.76%), training for healthcare professionals and community health agents (n = 2; 11.11%), and education on self-examination and fictional television works (n = 1; 5.76%). The main objectives were health education (n = 5; 27.78%) and deformity prevention (n = 6; 33.33%). Most strategies were led by healthcare professionals (n = 10; 55.56%) and targeted individuals affected by leprosy (n = 12; 66.67%). The most common level of engagement was Empower (n = 8; 44.44%) and none were identified as reaching Partner or Integrate levels, highlighting an important gap in strategies that promote deeper forms of engagement. CONCLUSIONS: The review highlights several engagement strategies, especially those enabling the levels Inform about Health and Empower. However, literature lacks strategies promoting deeper engagement, such as Partner and Integrate, highlighting the need for new approaches.Letícia Guedes Morais Gonzaga de Souza; João Lucas Braga Perin; Mariana Moreira Drumond; Carina Carvalho Silvestre; Sabrina Cerqueira-Santos; Genival Araujo dos Santos Júnior

Public health; Leprosy; Community engagement; Stigma (botany); Health education; Psychological intervention; Social stigma; Health promotion; Program evaluation; Medicine; Medical education; Family medicine; Qualitative research; Nursing; Data extraction; Health services research; Social media; Health communication; Gerontology; Health care; MEDLINE

2026-02-14https://doi.org/10.1186/s13690-026-01857-8Archives of Public Health 20261INTEGRATION OF ACTIVE LEARNING METHODOLOGIES IN THE TEACHING OF MAXILLOFACIAL PATHOLOGY: EXPERIENCE REPORT AND CRITICAL ANALYSISThis study aims to descriptively and reflectively report the experiences of undergraduate dental students who participated in active learning methodologies in the Maxillofacial Pathology II and III courses. This observational study explored the implementation of case-based, team-based, problem-based, and project-based learning strategies. These methodologies were employed throughout the academic semester and incorporated into the courses’ assessment criteria. The integration of active learning methodologies served as a pedagogical strategy to facilitate students’ knowledge construction. These approaches made learning more meaningful and enhanced information retention, while also promoting a more engaging, dynamic, and collaborative learning environment by valuing teamwork. However, successful implementation requires faculty training in active methodologies and active student engagement to achieve optimal learning outcomes. In conclusion, active learning methodologies proved to be effective instructional strategies, as they contributed to the development of essential competencies for the students’ professional education.Marco Antônio Fulco Júnior; Daniel José da Silva Honorio; Laura Rocha Martins; Ana Júlia Fortes Sena; Savio Abreu de Araújo; Lorrayne Naysla de Paula; Júlia Campos Fabri; Iasminy Soares de Oliveira Roeles; Gisele Maria Campos Fabri

Active learning (machine learning); Problem-based learning; Experiential learning; Teaching method; Cooperative learning; Blended learning; Collaborative learning; Computer science; Medical education; Learning cycle; Professional development; Educational measurement

2026-02-13https://doi.org/10.51891/rease.v12i2.24197Revista Ibero-Americana de Humanidades, Ciências e Educação 20261Monitoring adherence and patient-reported outcomes during subcutaneous immunotherapy for house dust mites with the AllergyVax app/web platformBackground: Adherence to treatment and outcome monitoring remain major challenges in allergen immunotherapy. Objective: This study evaluated a digital strategy for monitoring adherence and clinical outcomes of subcutaneous immunotherapy (SCIT) through the AllergyVax mobile and web platform. Methods: This prospective observational study followed 83 patients receiving SCIT through the AllergyVax digital platform for 12 months. Patient-reported outcomes were assessed with the Rhinitis Control Assessment Test and the Asthma Control Test at baseline and predefined follow-up intervals. Both adherence and clinical outcomes were analyzed longitudinally in the same patient group. Methodologic limitations include absence of a control group and relatively short follow-up. Results: The assessment of adherence to SCIT revealed that 84.3% of patients adhered to treatment, 7.2% were recovered adherent patients, and 8.4% dropped out after 12 months of treatment. We compared subgroups by analyzing adherence in patients with rhinitis alone versus those with rhinitis and asthma, as well as between male and female patients. None of the comparisons revealed statistically significant differences between the groups. Conclusions: The digital platform facilitates SCIT management by improving adherence and strengthening patient engagement.Matheus Fonseca Aarestrup; Fernando Monteiro Aarestrup; Paula Fonseca Aarestrup; Beatriz Julião V Aarestrup; Edir Paula Cheloni Aarestrup; Akinori Cardozo Nagato; José Otávio Amaral Correa

Dust mites; Immunotherapy; Patient-reported outcome; Quality of life (healthcare); MEDLINE; Medicine; Dermatology; Immunology

2026-02-14https://doi.org/10.1016/j.jacig.2026.100670Journal of Allergy and Clinical Immunology Global 20261Population Heterogeneity of Diabetes in Indigenous Peoples of the Americas: A Systematic Scoping Review of the Existing LiteratureBackground: In the Americas, the number of people living with diabetes is expected to rise from 92 million in 2024 to 120 million by 2050. Indigenous populations may experience distinct biological, environmental, and sociocultural risk factors; however, they are often treated as a homogeneous group in epidemiological research, and consolidated evidence on diabetes prevalence across diverse Indigenous populations remains limited. This scoping review examines the prevalence of diabetes among Indigenous populations in the Americas. Methods: Following PRISMA-ScR guidelines, we conducted a systematic scoping review of population-based studies reporting the prevalence of diabetes among Indigenous adult populations in the Americas. Searches were performed in PubMed and Scopus. Collected data included study location, Indigenous group, population characteristics, diagnostic criteria, and test used and reported prevalence estimates. Results: Sixty documents encompassing 73 studies met the inclusion criteria, representing 45,503 individuals from 16 countries between 1975 and 2025. The total number of ethnic groups represented was 111, and 12 studies did not identify a specific ethnic group. Fasting blood glucose (FBG) was the most frequently used diagnostic method, followed by the oral glucose tolerance test (OGTT). Estimates of the prevalence of diabetes varied widely across populations, regions, and time periods. Five studies—from Brazil, Chile, Colombia, Mexico, and Paraguay—did not identify any cases of diabetes. Among studies reporting cases, prevalence ranged from 1 to 70% in North America, 5 to 14% in Central America, and 1 to 29% in South America. Conclusions: The prevalence of diabetes among Indigenous populations varied widely across the region, with substantially higher estimates reported in North America than in Central and South America. The decline in published studies in recent years suggests reduced research attention to this topic. The marked heterogeneity identified in this review underscores the need for standardized measurement approaches to support population-specific strategies aligned with personalized care and precision public health.Alberto Barcelo; Roy Wong-McClure; Felicia Cañete; Ethel Santacruz; Noelia Cañete; Arise Garcia de Siqueira Galil

Indigenous; Ethnic group; Diabetes mellitus; Epidemiology; Population; Prevalence; Type 2 diabetes; MEDLINE; Medicine; Demography; Environmental health; Gerontology; Systematic review; Geography; Homogeneous

2026-02-14https://doi.org/10.3390/jpm16020116Journal of Personalized Medicine 20261Pressure-sensitive adhesive methodologies as a framework for advancing mucoadhesive testingLuciana Cláudia Diniz Tavares; Samuel Lopes de Souza; Raphael Fortes Marcomini; Ana Carolina Morais Apolônio

Mucoadhesion; Adhesive; Bioadhesive; Pharmaceutics; Materials science; Materials testing; Engineering; Nanotechnology

2026-02-14https://doi.org/10.1016/j.jddst.2026.108150Journal of Drug Delivery Science and Technology 20261Análise Numérica dos Efeitos da Corrosão Ascendente e Descendente em Pilares Metálicos de Pórticos de GalpõesObjective - To numerically evaluate the impact of atmospheric corrosion on the mechanical behavior of steel columns in portal frames, considering different heights and directions of deterioration propagation. The study aims to understand how thickness loss influences the stiffness and stability of the structure, supporting design and preventive maintenance decisions. Methodology - The research was carried out through numerical modeling using the Abaqus® software, based on the theoretical model proposed by Vogel (1985). Simulations were performed with B21 beam elements, using a 200 mm mesh size. Corrosion scenarios with progressive thickness reductions were considered over exposure periods of 7, 15, 25, and 50 years, according to the guidelines of ABNT NBR ISO 9223 (2024). Originality/Relevance - The work proposes an approach that correlates the height and direction of corrosion with the loss of structural performance, highlighting critical regions and typical deterioration patterns in steel columns. Results - The results show that ascending corrosion exhibits gradual effects, becoming significant only when it reaches approximately 1.0 m in height, whereas descending corrosion causes noticeable deterioration with extensions as small as 0.4 m. A reduction in stiffness and an earlier onset of structural instability were observed, even with small displacement variations. Theoretical/Methodological Contributions - The study enhances the understanding of localized corrosion effects in structural steel members, presenting a replicable finite element–based simulation method. Social and Environmental Contributions - The research reinforces the importance of durability and sustainability in steel structures, promoting the rational use of resources through preventive maintenance strategies and extension of service life. The practical application of the results may reduce rehabilitation costs, minimize material waste, and contribute to more resilient and environmentally responsible buildings.Camila Souza Carvalho; Maria Ávila Branquinho

Corrosion; Stiffness; Beam (structure); Durability; Reduction (mathematics); Work (physics); Finite element method; Displacement (psychology); Structural engineering; Materials science; Sustainability; Geotechnical engineering; Stability (learning theory); Material properties

2026-02-15https://doi.org/10.17271/23178604145020266243Periódico Técnico e Científico Cidades Verdes 20261Ciliate symbionts of bivalves with notes on their worldwide geographic distributionRosaura Mayén‐Estrada; Sthefane Dávila; Roberto Júnio Pedroso Dias

Ciliate; Ectotherm; Invertebrate; Population; Mollusca; Cosmopolitan distribution; Biology; Ecology; Zoology

2026-02-16https://doi.org/10.48580/dg7jqThe Catalogue of Life 20261Novelties on Lippia sect. Goniostachyum (Verbenaceae): a new variety from the Brazilian Cerrado and additional nomenclatural and taxonomic notesPedro Henrique Cardoso; Luiz Menini Neto; Marcelo Trovó; Fátima Regina Gonçalves Salimena

Variety (cybernetics); Lippia; Taxonomy (biology); Taxon; Key (lock); Biology; Geography

2026-02-16https://doi.org/10.48580/dghh7The Catalogue of Life 20261Exploring Sisyrinchium (Iridaceae) diversity in the Atlantic Forest Biome: three new species in S. sect. ViperellaCamila Dellanhese Inácio; Eduardo Damasceno Lozano; Kelly Antunes; Mabel R. Báez-Lizarazo; Lilian Eggers

Diversity (politics); Species diversity; Atlantic forest; Ectotherm; Biodiversity; Ecology; Geography

2026-02-16https://doi.org/10.48580/dtwjThe Catalogue of Life 20261Taxonomic updates in Brazilian Stachytarpheta (Verbenaceae) with atropurpureous to black corollas: Two new species and a new synonymPedro Henrique Cardoso; Luiz Menini Neto; Andressa Cabral; Marcelo Trovó

Synonym (taxonomy); Taxonomy (biology); Key (lock); Holotype; Biological classification; Biology; Geography; Zoology

2026-02-16https://doi.org/10.48580/d6p8The Catalogue of Life 20261A new species of Aplectana Railliet & Henry (Nematoda: Cosmocercidae) in Amphisbaena alba Linnaeus (Squamata: Amphisbaenidae) from Minas Gerais State, BrazilFabiano Matos Vieira; Paula Araujo Gonçalves; Sueli de Souza Lima; Bernadete Maria de Sousa; Luís Cláudio Muniz-Pereira

Taxonomy (biology); Ophidia; Paratype; Holotype; Biology; Zoology; Geography

2026-02-16https://doi.org/10.48580/df9cThe Catalogue of Life 20261A morphometric approach and recircumscription of the Stachytarpheta longispicata complex (Verbenaceae)Pedro Henrique Cardoso; Luiz Menini Neto; Nádia Silvia Somavilla; Marcelo Trovó

Telithromycin; Animal model; Component (thermodynamics); Biology; Medicine

2026-02-16https://doi.org/10.48580/d48vyThe Catalogue of Life 20261A long-hidden pigmy shows itself again after almost a century: the rediscovery and lectotypification of Pygmaeorchis brasiliensis (Laeliinae, Orchidaceae)Marcelo Rodrigues Miranda; Samyra Gomes Furtado; Luiz Menini Neto

Taxonomy (biology); Phylogenetic tree; Nomenclature; Holotype; Biology; Geography

2026-02-16https://doi.org/10.48580/d7bjThe Catalogue of Life 20261Systematic review of the genera Rhabdostyla Kent 1880 and Orborhabdostyla Foissner et al. 2010 (Ciliophora, Peritrichia, Epistylididae)Pedro Mendes De Souza; Mariana Fonseca Rossi; Roberto Júnio Pedroso Dias

Indigenous; Identification (biology); Exposition (narrative); History; Geography

2026-02-16https://doi.org/10.48580/dfr3zThe Catalogue of Life 20261Effects of pulmonary rehabilitation on the perception of happiness in individuals with COPD: A randomized clinical trialLayla Cristine de Toledo; Cristino Carneiro Oliveira; Joice Gomide Nolasco de Assis; Larissa Guimarães Paiva; Leandro Ferracini Cabral; Carla Malaguti; Anderson José

Randomized controlled trial; Perception; Happiness; Rehabilitation; Clinical trial; Medicine; Physical therapy; Pulmonary rehabilitation; Quality of life (healthcare); Physical medicine and rehabilitation

2026-02-16https://doi.org/10.1016/j.bjpt.2026.101577Brazilian Journal of Physical Therapy 20261A new species of Passiflora section Dysosmia (Passifloraceae s. s.) from the Atlantic Forest, southeast BrazilAndreza Magro Moraes; Michaele Alvim Milward-de-Azevedo; Ana Paula G. De Faria

Section (typography); Passiflora; Southeast asia; Subgenus; Taxonomy (biology); Geography; Biology

2026-02-16https://doi.org/10.48580/d4b5pThe Catalogue of Life 20261Passiflora acreana, a new species of Passiflora subgenus Passiflora (Passifloraceae sensu stricto) from Acre, BrazilAna Carolina Mezzonato‐Pires; M. Silveira; MAYK HONÓRIO

Subgenus; Passiflora; Sensu; Passifloraceae; Taxonomy (biology); Biology; Botany

2026-02-16https://doi.org/10.48580/dcb4sThe Catalogue of Life 20261Redescription and geographical distribution of Leiostracus obliquus (Reeve, 1849) (Mollusca, Gastropoda, Simpulopsidae)Maria Isabel P. F. Macedo; Ximena M. C. Ovando; Sthefane D'Ávila

Distribution (mathematics); Ectotherm; Population; Biogeography; Geography; Biology; Ecology

2026-02-16https://doi.org/10.48580/d4brlThe Catalogue of Life 20261A new combination in Verbenaceae and a new synonym in Lamiaceae from BrazilSalimena, Fátima Regina G.; Múlgura, Maria Ema; Harley, Raymond

Verbenaceae; Lamiaceae; Synonym (taxonomy); Key (lock); Biology; Geography

2026-02-16https://doi.org/10.48580/d8vpThe Catalogue of Life 20261A new proterochampsid (Archosauriformes: Proterochampsia) from the Late Triassic of southern Brazil and the emergence of archosaurian hind limb traitsRodrigo Temp Müller; Maurício Silva Garcia; André de Oliveira Fonseca

Hindlimb; Lower limb; Population; Ectotherm; Biology; Paleontology; Geography; Geology

2026-02-16https://doi.org/10.48580/d9rdzThe Catalogue of Life 20261On the type locality of Ameivula ocellifera (Spix, 1825) (Squamata, Teiidae), with a neotype designationEliana F. Oliveira; Henrique C. Costa; Vinícius A. São-Pedro; Ricardo Marques; Diego J. Santana; Guarino Rinaldi Colli; Daniel Oliveira Mesquita; Gabriel C. Costa

Type (biology); Type locality; Locality; Sequence (biology); Natural (archaeology); Geography

2026-02-16https://doi.org/10.48580/d9697The Catalogue of Life 20261In silico characterization of class II plant defensins from Arabidopsis thalianaLaura S.M. Costa; Allan; S. Pires; Neila B. Damaceno; Pietra O. Rigueiras; Mariana Rocha Maximiano; Octavio L. Franco; William F. Porto

In silico; Arabidopsis thaliana; Class (philosophy); Arabidopsis; Gene; Biology; Chemistry; Computational biology; Cell biology; Genetics; Biochemistry

2026-02-16https://doi.org/10.48580/ddvjdThe Catalogue of Life 20261Rediscovery of Obeliscus agassizi Pilsbry, 1906 (Gastropoda, Subulinidae, Obeliscinae), annotated checklist of species of Obeliscus Beck, 1837 and first description of the anatomy for the genusSthefane D'Ávila; Luiz Ricardo L. Simone; Luiz Fernando Cappa de Oliveira; Laurent Charles; Philippe Maestrati

Checklist; Genus; Taxonomy (biology); Single specimen; Zoology; Biology; Anatomy; Geography

2026-02-16https://doi.org/10.48580/dy7pThe Catalogue of Life 20261Checklist of ciliates (Alveolata: Ciliophora) that inhabit in bromeliads from the Neotropical RegionCarlos Alberto Durán-Ramírez; Roberto Júnio Pedroso Dias; Rosaura Mayén Estrada

Checklist; Taxonomy (biology); Biodiversity; Habitat; Invertebrate; Ecology; Biology; Geography

2026-02-16https://doi.org/10.48580/df3fThe Catalogue of Life 20261A checklist of species of the family Zoothamniidae (Ciliophora: Peritrichia) symbionts of crustaceansRosaura Mayén‐Estrada; Roberto Júnio Pedroso Dias

Crustacean; Checklist; Invertebrate; Taxonomy (biology); Key (lock); Biology; Zoology; Ecology

2026-02-16https://doi.org/10.48580/dbzyThe Catalogue of Life 20261The confused taxonomy of Pseudolaelia irwiniana (Orchidaceae) with two new synonymsBerg, Cassio Van Den; Luiz Menini Neto

Taxonomy (biology); Terminology; Synonym (taxonomy); Linguistics; Computer science; Natural language processing; Artificial intelligence

2026-02-16https://doi.org/10.48580/dgjzrThe Catalogue of Life 20261Abstract PS5-06-17: Sentinel lymph node biopsy after neoadjuvant chemotherapy in patients with breast cancer using blue dye alone: Results from a multicenter study in Public Hospitals in BrazilAbstract Introduction: In recent decades, breast cancer surgery has evolved from radical procedures to more conservative approaches, with emphasis on sentinel lymph node biopsy (SLNB), which reduces morbidity without compromising oncologic control. The introduction of neoadjuvant chemotherapy (NAC) has expanded the use of SLNB, even in patients with initially clinically positive axilla (cN1/N2) who converted to clinically negative status after treatment. However, the safety of this technique in cN1/N2 scenarios remains debated, especially given the lack of resources such as dual tracer techniques (using both blue dye and technetium for sentinel node identification) and lymph node clip placement in public health systems. Methods: This multicenter retrospective study analyzed 369 breast cancer patients treated with NAC between 2017 and 2021 at three public hospitals in Brazil. Patients were grouped according to their pre NAC axillary status and the type of axillary surgery performed, either SLNB or axillary lymph node dissection (ALND). All patients had clinically negative axilla following NAC. Objective: The primary objective was to evaluate axillary recurrence in patients who were initially cN1/N2 and converted to cN0. Results: Among patients who underwent SLNB using blue dye alone as the sole mapping method, the axillary recurrence rate was 2.4% in the group initially with clinically negative axilla (cN0) and 2.6% in the initially cN1/N2 group, with no statistical difference. Overall survival (OS) was also similar, at 94.1% in the cN0 group and 89.7% in the cN1/N2 group, without statistical significance (p=0.255), as were the other survival outcomes analyzed. When comparing initially cN1/N2 patients who underwent SLNB or ALND, similar axillary recurrence rates were observed: 2.6% in the SLNB group and 2.3% in the ALND group. OS of 89.7% and 87.8%, respectively, also showing no statistically significant difference. Furthermore, when all 163 patients who underwent SLNB were grouped regardless of initial axillary status and compared to the 206 patients who underwent ALND, the axillary recurrence rates remained comparable: 2.5% in the SLNB group and 1.9% in the ALND group. Other outcomes, including local and locoregional recurrence, disease-free survival, distant disease-free survival and overall survival, also showed similar results between groups. Conclusion: SLNB with blue dye alone, even without complementary techniques, demonstrated acceptable oncologic safety in patients who converted to cN0 after NAC. These findings are especially relevant in resource-limited settings and support the use of less invasive strategies to reduce complications without compromising therapeutic effectiveness. Further studies are needed to validate these results. Keywords: Breast cancer; Sentinel lymph node biopsy; Neoadjuvant chemotherapy; Axillary lymph node dissection; Public Health System. Citation Format: C. Lopes, R. S. Machado, S. Trota, T. Orge, L. Oliveira, D. Torres, F. Bacellar, S. Paiva, L. Piana, J. Bines. Sentinel lymph node biopsy after neoadjuvant chemotherapy in patients with breast cancer using blue dye alone: Results from a multicenter study in Public Hospitals in Brazil [abstract]. In: Proceedings of the San Antonio Breast Cancer Symposium 2025; 2025 Dec 9-12; San Antonio, TX. Philadelphia (PA): AACR; Clin Cancer Res 2026;32(4 Suppl):Abstract nr PS5-06-17.C. Lopes; R. S. Machado; S. Trota; T. Orge; L. Oliveira; D. Torres; F. Bacellar; S. Paiva; L. Piana; José Bines

Axilla; Sentinel lymph node; Breast cancer; Axillary Lymph Node Dissection; Biopsy; Sentinel node; Lymph node; Retrospective cohort study; Neoadjuvant therapy; Medicine; Surgery; Chemotherapy; Lymph; Radiology; Axillary Dissection; Multicenter study; Axillary lymph nodes; Breast surgery; Wide local excision

2026-02-17https://doi.org/10.1158/1557-3265.sabcs25-ps5-06-17Clinical Cancer Research 20261A new species of Aplectana Railliet & Henry (Nematoda: Cosmocercidae) in Amphisbaena alba Linnaeus (Squamata: Amphisbaenidae) from Minas Gerais State, BrazilFabiano Matos Vieira; Paula Araujo Gonçalves; Sueli de Souza Lima; Bernadete Maria de Sousa; Luís Cláudio Muniz-Pereira

Taxonomy (biology); Ophidia; Paratype; Holotype; Biology; Zoology; Geography

2026-02-17https://doi.org/10.48580/df9c.v83The Catalogue of Life 20261Computational science in bioinformatics and biomedicine: From modeling and simulation, to knowledge extraction and artificial intelligenceMario Cannataro; Giuseppe Agapito; Mauro Castelli; Riccardo Dondi; Rodrigo Weber dos Santos; Italo Zoppis

Biomedicine; Computational model; Big data; Computational intelligence; Structural bioinformatics; Biological data; Computational genomics; Grand Challenges; Translational bioinformatics; Computer science; Data science; Artificial intelligence; Visualization; Preprocessor; Modelling biological systems; Knowledge extraction; Computational complexity theory; Supercomputer; Key (lock); Computational problem

2026-02-17https://doi.org/10.1016/j.jocs.2026.102816Journal of Computational Science 20261Letter: The Unresolved Issue of <scp>NSBB</scp> Confounding in Statin Research for Cirrhosis—Authors' ReplyWe thank Huang and colleagues [1] for their thoughtful letter and for highlighting the critical role of non-selective beta-blockers (NSBBs) as a potential effect modifier in the relationship between statin therapy and clinical outcomes in cirrhosis. We agree that the interplay between statins and NSBBs is central to the pharmacotherapy of portal hypertension, and that heterogeneity in NSBB exposure across studies may introduce confounding and contribute to between-study variability. While our original publication [2] partially addressed this issue via a sensitivity analysis for the haemodynamic outcome of hepatic venous pressure gradient (HVPG), we acknowledge that applying similarly rigorous approaches to clinical endpoints would be informative and could further clarify whether the observed benefits of statins are independent of, or synergistic with, concomitant NSBB therapy. In response to their suggestion, we performed a post hoc sensitivity analysis of all-cause mortality and hepatic decompensation, restricting inclusion to the randomised controlled trials (RCTs) where NSBBs were administered as a standardised co-intervention in both study arms [3-6]. Within this NSBB-standardised subset, statin therapy remained significantly associated with lower all-cause mortality (OR 0.39; 95% CI 0.21–0.74; I2 = 0.0%) (Figure 1A). This finding suggests that the survival benefit of statins may be additive to that of NSBBs and could plausibly reflect pleiotropic effects beyond portal pressure reduction, including improvements in liver microvascular function, nitric oxide regeneration and modulation of systemic inflammation. For hepatic decompensation, the NSBB-standardised subset yielded an OR of 0.68 (95% CI 0.46–1.02; I2 = 0.0%) (Figure 1B). Consistent with the overall RCT analysis, this estimate did not reach conventional statistical significance, although the direction of effect remained protective and aligned with the signal observed across observational studies. This is relevant, as the cardiovascular/metabolic benefits of statins typically emerge with prolonged treatment and are well established in long-term follow-up studies [7, 8]. Accordingly, the absence of statistical significance for decompensation in RCTs may reflect limited follow-up and/or power rather than the absence of a biologically meaningful effect, especially in the light of the consistent mortality and haemodynamic signals. We acknowledge, however, that NSBB use is incompletely and inconsistently reported in observational cohorts, which limits the ability to adequately account for this key covariate. Although adjusted analyses were used where available, observational evidence remains susceptible to residual confounding and should be interpreted cautiously. While these findings are encouraging, we recognise that heterogeneity in treatment duration/doses, types of statins used, disease severity/stage and cirrhosis aetiology remain other major limitations of the current evidence base. Adequately powered, large-scale trials with standardised concomitant NSBB therapy, careful phenotyping of portal hypertension stage and sufficient follow-up will be essential to more definitively delineate the independent (and potentially synergistic) effects of statin therapy on clinically meaningful endpoints. In the interim, we continue to support the Baveno VII [9] recommendation to encourage statin use in patients with cirrhosis who have an approved indication, with appropriate caution in decompensated disease. At the same time, we note with excitement that the growing body of evidence raises the possibility that statins may ultimately assume a broader role as disease-modifying agents in cirrhosis. Bernardo de Faria Moraes: conceptualization, writing – original draft, methodology, formal analysis, data curation. Gustavo André Pedral Diniz Leite: conceptualization, investigation. Igor Boechat Silveira: conceptualization, investigation. Gabriel André Pedral Diniz Leite: conceptualization, investigation. Maria Luisa Motta Fonseca: conceptualization, investigation. Leonardo Corrêa Suffert: conceptualization, investigation. Luisa Medeiros Visentini: conceptualization, investigation. Luis Pedro Possapp Beis: conceptualization, investigation. Guilherme Grossi Lopes Cançado: conceptualization, validation, supervision, writing – review and editing, data curation. The authors have nothing to report. The authors have nothing to report. The authors declare no conflicts of interest. This article is linked to Moraes et al. papers. To view these articles, visit https://doi.org/10.1111/apt.70526 and https://doi.org/10.1111/apt.70558. The data that support the findings of this study are available from the corresponding author upon reasonable request.Bernardo de Faria Moraes; Gustavo André Pedral Diniz Leite; Igor Boechat Silveira; Gabriel André Pedral Diniz Leite; Maria Luisa Motta Fonseca; LEONARDO CORREA SÜFFERT; Luisa Medeiros Visentini; Luis Pedro Possapp Beis; Guilherme Grossi Lopes Cançado

Confounding; Statin; Randomized controlled trial; Concomitant; Pharmacotherapy; Clinical trial; Blood pressure; Meta-analysis; Medicine; Internal medicine; Intensive care medicine; Cardiology; Nitric oxide; HMG-CoA reductase; MEDLINE

2026-02-16https://doi.org/10.1111/apt.70563Alimentary Pharmacology & Therapeutics 20261Redescription and geographical distribution of Leiostracus obliquus (Reeve, 1849) (Mollusca, Gastropoda, Simpulopsidae)Maria Isabel P. F. Macedo; Ximena M. C. Ovando; Sthefane D'Ávila

Distribution (mathematics); Ectotherm; Population; Biogeography; Geography; Biology; Ecology

2026-02-17https://doi.org/10.48580/d4brl.v18The Catalogue of Life 20261Automated Calculation of the Disruption Index: A Reproducible Computational Workflow for Large-Scale Bibliometric AnalysesABSTRACT Bibliometric analyses have become essential for understanding scientific production and innovation dynamics; however, large-scale applications remain limited by challenges related to data extraction, preprocessing, citation network reconstruction, and reproducibility, particularly when using PubMed-indexed records. This study presents a fully automated and reproducible computational workflow for large-scale bibliometric analyses based on the Disruption Index (DI). The pipeline enables systematic retrieval of PubMed data, standardized metadata processing, construction of citation networks, and calculation of DI values within a fixed post-publication citation window. Implemented in Python, the workflow integrates automated querying, XML parsing, data consolidation, and network-based citation classification, allowing scalable and transparent analyses that are infeasible through manual approaches. In a demonstrative application focused on orthodontic literature, the pipeline processed more than 67,000 articles and reconstructed over 300,000 citation relationships, resulting in a final analytical sample of 3,234 articles with indexed references and citations. The automated framework ensures methodological transparency, facilitates replication, and substantially reduces the time and technical barriers associated with advanced bibliometric studies. By providing an open and extensible solution for calculating the Disruption Index at scale, this workflow supports robust assessments of scientific innovation and consolidation and can be readily adapted to other biomedical research domains indexed in PubMed.Analina Braga Apolinário; Kaio Vinicius Vieira; Ana Karolina Mendes Mathias Costa; L. C. Lucas Freitas; Isabela Sales Pinheiro; Robert Willer Farinazzo Vitral; Márcio José da Silva Campos

Workflow; Pipeline (software); Metadata; Scalability; Science Citation Index; XML; Bibliometrics; Citation; Computer science; Data science; Data mining; Information retrieval; Database; Consistency (knowledge bases); Search engine indexing; Citation analysis; Software engineering

2026-02-16https://doi.org/10.64898/2026.02.12.705484bioRxiv (Cold Spring Harbor Laboratory) 20261A checklist of species of the family Zoothamniidae (Ciliophora: Peritrichia) symbionts of crustaceansRosaura Mayén‐Estrada; Roberto Júnio Pedroso Dias

Crustacean; Checklist; Invertebrate; Taxonomy (biology); Key (lock); Biology; Zoology; Ecology

2026-02-17https://doi.org/10.48580/dbzy.v90The Catalogue of Life 20261Conceptual evolution and methodological challenges of value-added in educational assessment: A scoping review 1971–2024Refers to: The bibliometric data used in the study “Conceptual evolution and methodological challenges of value aggregation in educational evaluation: a scoping review (1971–2024)”. The appendix of the study.Macêdo, Kelly Alice Barbosa; Ferrão, Maria Eugénia; Vieira, Marcel de Toledo

2026-01-01https://doi.org/10.5281/zenodo.18665963Zenodo (CERN European Organization for Nuclear Research) 20261Sleep in adolescence and suicidal ideationThis study analyzed sociodemographic and sleep-related factors associated with suicidal ideation among adolescents in public schools in Florianópolis, Brazil. The cross-sectional study included 1026 adolescents (14–19 years; 51.3% boys). Suicidal ideation (dependent variable) was assessed through three dimensions: thoughts, planning, and attempts. Associations were tested with sociodemographics, sleep duration, daytime sleepiness, and subjective sleep need. Prevalence rates were 22.1% (thoughts), 13.2% (planning), and 8.0% (attempts), with higher rates among girls (p < 0.001). Logistic regression showed girls had 1.96-fold higher odds of suicidal thoughts (95%CI:1.41–2.71) vs. boys; adolescents aged 14–16 had 1.46-fold higher odds (95%CI:1.07–2.01) vs. 17–19-year-olds. Excessive daytime sleepiness (OR = 2.00; 95%CI:1.36–2.92) and perceiving a need for ≥3 hours more sleep (OR = 1.51; 95%CI:1.06–2.17) were significant risk factors. Female sex and daytime sleepiness showed the strongest associations with suicidal ideation, highlighting the need for early screening in sleep-deprived adolescents.Jéssica de Jesus Dutra Lopes; Brunna Haryel Rosa Martins Honorato; Andreia Meneghetti; Rubian Diego Andrade; Andréia Pelegrini; Érico Pereira Gomes Felden

Suicidal ideation; Logistic regression; Odds; Odds ratio; Sleep (system call); Excessive daytime sleepiness; Ideation; Injury prevention; Clinical psychology; Medicine; Psychiatry; Psychology; Suicide prevention; Poison control; Depression (economics); Affect (linguistics); Demography

2026-02-17https://doi.org/10.1080/09291016.2026.2626769Biological Rhythm Research 20261Hybrid evolutionary machine learning framework optimizing biochar production in biomass pyrolysisGrowing interest in renewable energy worldwide has heightened the need for efficient modeling of biomass conversion. This study proposes a hybrid framework coupling five machine-learning models (ELM, ANN, RF, SVR, and XGB) with six population-based optimizers (SGA, PSO, DE, ABC, GWO, and xNES) to predict biochar yield in biomass pyrolysis. The database contains 423 experimental records from 44 lignocellulosic feedstocks, integrating proximate/elemental properties with operating conditions. Five learning algorithms were benchmarked, and each was tuned by every optimizer, enabling a systematic direct comparison of 30 hybrid configurations. Evolutionary hyperparameter tuning, evaluated using 5-fold cross-validation and 30 stratified train–test repetitions, improved accuracy and generalization relative to non-optimized learners. The best configuration (ABC–XGB) achieved R 2 = 0 . 815 , RMSE = 3.845, and MAE = 2.199 on the test sets. ANOVA ( p < 0 . 05 ) indicates that performance differences are driven mainly by the ML estimator rather than the optimizer, although DE, ABC, and GWO provided stable tuning across runs. Reliability was further examined using propagation-based uncertainty quantification with bounded input sampling, yielding narrow confidence intervals, near-zero mean prediction error, and low variability. The proposed evolutionary-ML surrogate model captures nonlinear thermochemical relationships and supports the design, optimization, and control of biomass pyrolysis and related bioenergy systems.Deivid Campos; Ricardo Ervilha; Matteo Bodini; Camila Martins Saporetti; Leonardo Goliatt

Biochar; Biomass (ecology); Hyperparameter; Bioenergy; Evolutionary algorithm; Generalization; Yield (engineering); Reliability (semiconductor); Computer science; Machine learning; Environmental science; Renewable energy; Pyrolysis; Mathematics; Mean squared error; Estimator; Support vector machine; Artificial intelligence

2026-02-17https://doi.org/10.1016/j.fuproc.2026.108419Fuel Processing Technology 20261Readaptação Funcional e Sofrimento Psíquico na Enfermagem: Análise Crítica Sobre a Gestão do TrabalhoObjetivo: Analisar as repercussões da readaptação funcional informal e do desvio de função na saúde mental de uma enfermeira do setor público. Método: Relato de experiência descritivo-reflexivo, fundamentado na vivência profissional em uma instituição pública de saúde. A análise foi realizada mediante a articulação da prática institucional com a literatura sobre saúde do trabalhador, enfermagem, gestão do trabalho e as diretrizes da Organização Mundial da Saúde. Resultados: A ausência de formalização pericial e de planejamento organizacional converteu a readaptação em um isolamento funcional. O ambiente administrativo, desprovido de suporte e com ambiguidade de papéis, atuou como novo estressor, intensificando o sofrimento ético-político e a desvalorização profissional. Conclusão: A readaptação, quando reduzida a um manejo administrativo sem amparo técnico, falha em seu caráter protetivo e agrava o adoecimento mental. Evidencia-se a necessidade de modelos de gestão que promovam ambientes laborais compatíveis com as condições dos profissionais de enfermagem.Raquel dos Santos Rosa Peixoto

Data collection; Work (physics); Context (archaeology); Field (mathematics); Event (particle physics); Qualitative research; Psychology; Social psychology; Developmental psychology

2026-02-18https://doi.org/10.36489/nursing.2026v31i333p13171-13179Nursing Edição Brasileira 20261Catalyst-free visible-light mediated α-alkylation of quinazolines and pyrrolo[2,1-f][1,2,4]triazineQuinazolines are found in numerous commercially available drugs. Herein, we report a catalyst-free photochemical approach for the direct alkylation of these N -heterocycles under mild conditions. Additionally, late-stage functionalization of bioactive natural products—including caffeine, quinine derivative and flavone—was successfully achieved. Notably, the protocol also enabled the selective C7-functionalization of the pyrrolo[2,1- f ][1,2,4]triazine core without requiring pre-functionalization, representing the first example of this transformation accomplished through a photochemical process. Using the optimized reaction condition, 17 alkylated heterocycles were prepared in 10-81% yield. • Alkylation of aminoquinazolines and derivatives through a photochemical process • First report of photochemical alkylation in pyrrolo[2,1- f ][1,2,4]triazine • Mild conditions for C-H functionalization in compounds of biological potentialJhonathan R. N. dos Santos; Victor Biagio A. Sciota; Geovana F. Vargas; Camila Batista Pinto; Giovanni W. Amarante; Javier Ellena; Arlene G. Corrêa

Alkylation; Surface modification; Derivative (finance); Reaction conditions; Transformation (genetics); Chemistry; Combinatorial chemistry; Organic chemistry; Photochemistry

2026-02-18https://doi.org/10.1016/j.tet.2026.135195Tetrahedron 20261Book Review: Alternative (Im)Mobilities by Maria Alice de Faria Nogueira de Faria NogueiraMaria Alice (ed.), Alternative (Im)Mobilities (Abingdon and New York: Routledge, 2023), 159 pp., $53.99. ISBN: 9781032124315.Leonardo Francisco de Azevedo

Alice (programming language); Master/slave; Art; Art history; Humanities

2026-02-18https://doi.org/10.1177/00225266261422996The Journal of Transport History 20261Self-selected Recovery in High-intensity Interval Training Promotes Positive Responses in Affect, Pleasure, and Mood in Young PeopleIntroduction High-Intensity Interval Training (HIIT) with self-selected recovery can promote positive emotional responses. This study aimed to verify the acute responses to HIIT with fixed recovery and to select high scorers on the state of affect, enjoyment, and mood in healthy young people. Methods Nineteen participants took part in the study (19.0±1.0 years, 64.0±9.2 kg, 169.1±8.5, and 22.0±2.0 BMI). They performed 10 x 30 s (95% V peak ) with 1 min recovery (HIIT RecA - active - 40% V peak ) and self-selected (HIIT Rec-B ). Affect, enjoyment, and mood were assessed before and after HIIT (both conditions). Results In both conditions, for time 1 and 2 were positive in positive ( p =.170, EF: .102) and negative ( p =.0.90, EF: .151) affect, pleasure ( p =.010, EF: .315), and mood domains (tension: p <.001, EF: .673; depression: p =.015, EF: .286), anger: p =.033, EF: .230, and mental confusion: p <.001, EF: .451). In contrast, there was a reduction in the vigor domain and an increase in fatigue, with no differences in all emotional variables for condition and time*condition ( p >.05). Conclusion Thus, selected self-recovery may be a strategy in prescribing HIIT with possibilities of not interfering with the emotional aspects, researched here.Leandro Sant’Ana; Jeferson Macedo Vianna; Bruno Travassos; Fábio Yuzo Nakamura; Diogo Teixeira; Fabiana Rodrigues Scartoni; Amândio Dias; Raul Antunes; Filipe Rodrigues; Rui Matos; Sérgio Machado; Diogo Monteiro

Mood; Interval training; Affect (linguistics); Interval (graph theory); Emotional regulation; High-intensity interval training; Psychology; Clinical psychology; Pleasure; Association (psychology); Medicine; Developmental psychology

2026-02-18https://doi.org/10.2174/0117450179378796260109054752Clinical Practice and Epidemiology in Mental Health 20261Additional file 1 of Brazilian Society of Rheumatology – 2025 recommendations on vaccination in immune-mediated rheumatic diseasesSupplementary Material 1Gecilmara Salviato Pileggi; Vítor Alves Cruz; Ana Cristina de Medeiros-Ribeiro; Ana Karla Guedes de Melo; André Gustavo Cunha Trolese; Anna Carolina Faria Moreira Gomes Tavares; Zerbini, Cristiano Augusto de Freitas; Erika Biegelmeyer; Flávia Maria Matos Melo Campos Peixoto; Gilda Aparecida Ferreira; Joana Starling de Carvalho; Ketty Lysie Libardi Lira Machado; Lílian David de Azevedo Valadares; M. Pinheiro; NATALIA SARZI SARTORI; Priscila Dias Cardoso Ribeiro; Rejane Maria Rodrigues de Abreu Vieira; R. São Francisco Xavier; Sandra Lúcia Euzébio Ribeiro; Vanessa de Oliveira Magalhães; Viviane Angelina de Souza

Vaccination; Rheumatology; Epidemiology; MEDLINE; Rheumatoid arthritis; Medicine; Family medicine; Internal medicine

2026-01-01https://doi.org/10.6084/m9.figshare.31367670Figshare 20261Additional file 3 of Brazilian Society of Rheumatology – 2025 recommendations on vaccination in immune-mediated rheumatic diseasesSupplementary Material 3Gecilmara Salviato Pileggi; Vítor Alves Cruz; Ana Cristina de Medeiros-Ribeiro; Ana Karla Guedes de Melo; André Gustavo Cunha Trolese; Anna Carolina Faria Moreira Gomes Tavares; Zerbini, Cristiano Augusto de Freitas; Erika Biegelmeyer; Flávia Maria Matos Melo Campos Peixoto; Gilda Aparecida Ferreira; Joana Starling de Carvalho; Ketty Lysie Libardi Lira Machado; Lílian David de Azevedo Valadares; M. Pinheiro; NATALIA SARZI SARTORI; Priscila Dias Cardoso Ribeiro; Rejane Maria Rodrigues de Abreu Vieira; R. São Francisco Xavier; Sandra Lúcia Euzébio Ribeiro; Vanessa de Oliveira Magalhães; Viviane Angelina de Souza

Vaccination; Rheumatology; MEDLINE; Epidemiology; Alternative medicine; Medicine; Family medicine; Internal medicine

2026-01-01https://doi.org/10.6084/m9.figshare.31367676.v1Figshare 20261Biomarcadores Moleculares na Detecção Precoce do Câncer BucalMaíla Silva Marciano; Maria Eduarda da Silva Felix; Giovana Caroline Siqueira Batista; Dhafny Marcolino Dias; Isabella Correa de Paula; Ana Beatriz do Nascimento; Nayara Cristina de Sousa; Gabryelle Geovana Bento; Larissa Cazarim Elias; Tony Eduardo Costa; Gisele Maria Campos Fabri

Disease; Incidence (geometry); Population; Epidemiology; MEDLINE; Medicine

2026-02-11https://doi.org/10.22533/at.ed.8208242610025Revista Brasileira de Saúde 20261Additional file 2 of Brazilian Society of Rheumatology – 2025 recommendations on vaccination in immune-mediated rheumatic diseasesSupplementary Material 2Gecilmara Salviato Pileggi; Vítor Alves Cruz; Ana Cristina de Medeiros-Ribeiro; Ana Karla Guedes de Melo; André Gustavo Cunha Trolese; Anna Carolina Faria Moreira Gomes Tavares; Zerbini, Cristiano Augusto de Freitas; Erika Biegelmeyer; Flávia Maria Matos Melo Campos Peixoto; Gilda Aparecida Ferreira; Joana Starling de Carvalho; Ketty Lysie Libardi Lira Machado; Lílian David de Azevedo Valadares; M. Pinheiro; NATALIA SARZI SARTORI; Priscila Dias Cardoso Ribeiro; Rejane Maria Rodrigues de Abreu Vieira; R. São Francisco Xavier; Sandra Lúcia Euzébio Ribeiro; Vanessa de Oliveira Magalhães; Viviane Angelina de Souza

Vaccination; Rheumatology; MEDLINE; Epidemiology; Rheumatoid arthritis; Medicine; Family medicine; Internal medicine

2026-01-01https://doi.org/10.6084/m9.figshare.31367673.v1Figshare 20261Additional file 2 of Brazilian Society of Rheumatology – 2025 recommendations on vaccination in immune-mediated rheumatic diseasesSupplementary Material 2Gecilmara Salviato Pileggi; Vítor Alves Cruz; Ana Cristina de Medeiros-Ribeiro; Ana Karla Guedes de Melo; André Gustavo Cunha Trolese; Anna Carolina Faria Moreira Gomes Tavares; Zerbini, Cristiano Augusto de Freitas; Erika Biegelmeyer; Flávia Maria Matos Melo Campos Peixoto; Gilda Aparecida Ferreira; Joana Starling de Carvalho; Ketty Lysie Libardi Lira Machado; Lílian David de Azevedo Valadares; M. Pinheiro; NATALIA SARZI SARTORI; Priscila Dias Cardoso Ribeiro; Rejane Maria Rodrigues de Abreu Vieira; R. São Francisco Xavier; Sandra Lúcia Euzébio Ribeiro; Vanessa de Oliveira Magalhães; Viviane Angelina de Souza

Vaccination; Rheumatology; MEDLINE; Epidemiology; Rheumatoid arthritis; Medicine; Family medicine; Internal medicine

2026-01-01https://doi.org/10.6084/m9.figshare.31367673Figshare 20261Brazilian Society of Rheumatology – 2025 recommendations on vaccination in immune-mediated rheumatic diseasesAbstract Background Patients with immune-mediated rheumatic diseases (IMRD) are at increased risk for infections due to both disease-related immune dysregulation and immunosuppressive therapy. Despite the benefits of vaccination, immunization rates in this population remain suboptimal, often due to concerns about safety, efficacy, and their potential for inducing disease flare. Regional-specific guidelines are necessary to address the particular epidemiological issues and aspects of the healthcare systems, especially in countries like Brazil. Objective To provide updated, evidence-based, and nationally relevant recommendations on vaccination in adult patients with IMRD in Brazil, focusing on immunogenicity, safety and disease activity outcomes. Methods A multidisciplinary task force from the Brazilian Society of Rheumatology conducted a systematic review and meta-analysis of studies addressing eleven clinical questions related to vaccine safety and efficacy in IMRD. Studies were selected using predefined PICO criteria. Risk of bias was assessed using JBI tools, and the certainty of evidence was evaluated with the GRADE approach. Statements were developed and submitted to a Delphi-based voting process; consensus was achieved if ≥80% of the panelists voted “agree” or “strongly agree” for all the statements. Results Eleven recommendations were developed based on a systematic review of the literature, with meta-analyses conducted when appropriate. Inactivated vaccines demonstrated a favorable safety profile, with low flare rates and no significant increase in disease activity, even under immunosuppression. Live attenuated vaccines, including yellow fever, were considered safe when administered according to timing protocols. Immunogenicity may be reduced in patients receiving methotrexate, mycophenolate, corticosteroids, rituximab, and JAK inhibitors, although this does not appear to compromise clinical protection in most cases. Temporary treatment interruption was associated with improved immunogenicity in selected contexts, but without consistent evidence of clinical benefit and with potential risks related to disease control. Specific guidance was provided for influenza and hepatitis B vaccination, as well as for prioritizing vaccination before initiating immunosuppression whenever feasible. Statements also addressed the approach to revaccination and post-vaccination serologic testing. Despite the overall very low to moderate certainty of evidence, most recommendations reached strong consensus (≥80% agreement). Shared decision-making and individualized strategies were emphasized across all scenarios. Conclusion These recommendations offer tailored guidance for improving vaccination strategies in IMRD patients in Brazil. Given the heterogeneity of evidence, clinical decisions should be individualized, considering disease activity, treatment regimen, vaccine availability, and patient preferences. Shared decision-making is essential in all scenarios to enhance vaccine uptake and align preventive care with patient-centered management.Gecilmara Salviato Pileggi; Vítor Alves Cruz; Ana Cristina de Medeiros-Ribeiro; Ana Karla Guedes de Melo; André Gustavo Cunha Trolese; Anna Carolina Faria Moreira Gomes Tavares; Zerbini, Cristiano Augusto de Freitas; Erika Biegelmeyer; Flávia Maria Matos Melo Campos Peixoto; Gilda Aparecida Ferreira; Joana Starling de Carvalho; Ketty Lysie Libardi Lira Machado; Lílian David de Azevedo Valadares; M. Pinheiro; NATALIA SARZI SARTORI; Priscila Dias Cardoso Ribeiro; Rejane Maria Rodrigues de Abreu Vieira; R. São Francisco Xavier; Sandra Lúcia Euzébio Ribeiro; Vanessa de Oliveira Magalhães; Viviane Angelina de Souza

Vaccination; Systematic review; Population; Epidemiology; Disease; Disease; Immunization; Rheumatology; Health care; Medicine; Family medicine; Intensive care medicine; Public health; MEDLINE; Meta-analysis; Herd immunity; Immunogenicity; Immunology; Alternative medicine; Clinical trial; Multidisciplinary approach

2026-01-01https://doi.org/10.6084/m9.figshare.c.8317053Figshare 20261Additional file 3 of Brazilian Society of Rheumatology – 2025 recommendations on vaccination in immune-mediated rheumatic diseasesSupplementary Material 3Gecilmara Salviato Pileggi; Vítor Alves Cruz; Ana Cristina de Medeiros-Ribeiro; Ana Karla Guedes de Melo; André Gustavo Cunha Trolese; Anna Carolina Faria Moreira Gomes Tavares; Zerbini, Cristiano Augusto de Freitas; Erika Biegelmeyer; Flávia Maria Matos Melo Campos Peixoto; Gilda Aparecida Ferreira; Joana Starling de Carvalho; Ketty Lysie Libardi Lira Machado; Lílian David de Azevedo Valadares; M. Pinheiro; NATALIA SARZI SARTORI; Priscila Dias Cardoso Ribeiro; Rejane Maria Rodrigues de Abreu Vieira; R. São Francisco Xavier; Sandra Lúcia Euzébio Ribeiro; Vanessa de Oliveira Magalhães; Viviane Angelina de Souza

Vaccination; Rheumatology; MEDLINE; Epidemiology; Alternative medicine; Medicine; Family medicine; Internal medicine

2026-01-01https://doi.org/10.6084/m9.figshare.31367676Figshare 20261Influence of anticoagulants and processing time in haematological analysis in butter ray ( Dasyatis hypostigma – <scp>Santos & Carvalho</scp> , 2004), maintained under human careAbstract Dasyatis hypostigma is a species of ray found primarily in coastal and estuarine waters of the Atlantic Ocean. It plays an important role in marine ecosystems by regulating populations of small fish and invertebrates. The aim of this study was to evaluate the influence of different anticoagulants and processing times on the haematological parameters of D. hypostigma , as well as to describe the morphology of its blood cells. Blood samples from 11 D. hypostigma individuals housed at the Marine Aquarium of Rio de Janeiro were collected following tonic immobilization techniques and distributed into tubes containing different anticoagulants (K 2 EDTA, sodium citrate, lithium heparin and sodium heparin). The samples were analysed immediately after collection and again 6 h later. The results showed significant effects of the anticoagulants on haematological parameters such as packed cell volume, mean corpuscular haemoglobin concentration and mean corpuscular volume. Time also influenced some parameters, particularly in samples treated with sodium heparin, where minor variations in cell counts were observed. Morphological analysis of the blood cells revealed typical characteristics of various leukocytes, erythrocytes and thrombocytes. Lithium heparin is the anticoagulant of choice for processing blood samples from D. hypostigma , although sodium heparin may also be used. EDTA and citrate should not be used for this species. Samples should be processed as promptly as possible. To the best of our knowledge, this is the first study to describe the blood cell morphology of D. hypostigma .Marthiellen Roosevelt de Lima Felix; Verônica Takatsuka; Amadeo A. Alcantara; Matheus Felix de Góes; Larissa de Souza Mendes; Wellington Bandeira da Silva; Guilherme Nunes de Souza; Aline Moreira de Souza

Anticoagulant; Heparin; Sodium; Sodium citrate; Heparin sodium; Blood cell; Biology; Whole blood; Red blood cell; Human blood; Animal science; Physiology; Estuary

2026-02-19https://doi.org/10.1111/jfb.70360Journal of Fish Biology 20261Brazilian Society of Rheumatology – 2025 recommendations on vaccination in immune-mediated rheumatic diseasesAbstract Background Patients with immune-mediated rheumatic diseases (IMRD) are at increased risk for infections due to both disease-related immune dysregulation and immunosuppressive therapy. Despite the benefits of vaccination, immunization rates in this population remain suboptimal, often due to concerns about safety, efficacy, and their potential for inducing disease flare. Regional-specific guidelines are necessary to address the particular epidemiological issues and aspects of the healthcare systems, especially in countries like Brazil. Objective To provide updated, evidence-based, and nationally relevant recommendations on vaccination in adult patients with IMRD in Brazil, focusing on immunogenicity, safety and disease activity outcomes. Methods A multidisciplinary task force from the Brazilian Society of Rheumatology conducted a systematic review and meta-analysis of studies addressing eleven clinical questions related to vaccine safety and efficacy in IMRD. Studies were selected using predefined PICO criteria. Risk of bias was assessed using JBI tools, and the certainty of evidence was evaluated with the GRADE approach. Statements were developed and submitted to a Delphi-based voting process; consensus was achieved if ≥80% of the panelists voted “agree” or “strongly agree” for all the statements. Results Eleven recommendations were developed based on a systematic review of the literature, with meta-analyses conducted when appropriate. Inactivated vaccines demonstrated a favorable safety profile, with low flare rates and no significant increase in disease activity, even under immunosuppression. Live attenuated vaccines, including yellow fever, were considered safe when administered according to timing protocols. Immunogenicity may be reduced in patients receiving methotrexate, mycophenolate, corticosteroids, rituximab, and JAK inhibitors, although this does not appear to compromise clinical protection in most cases. Temporary treatment interruption was associated with improved immunogenicity in selected contexts, but without consistent evidence of clinical benefit and with potential risks related to disease control. Specific guidance was provided for influenza and hepatitis B vaccination, as well as for prioritizing vaccination before initiating immunosuppression whenever feasible. Statements also addressed the approach to revaccination and post-vaccination serologic testing. Despite the overall very low to moderate certainty of evidence, most recommendations reached strong consensus (≥80% agreement). Shared decision-making and individualized strategies were emphasized across all scenarios. Conclusion These recommendations offer tailored guidance for improving vaccination strategies in IMRD patients in Brazil. Given the heterogeneity of evidence, clinical decisions should be individualized, considering disease activity, treatment regimen, vaccine availability, and patient preferences. Shared decision-making is essential in all scenarios to enhance vaccine uptake and align preventive care with patient-centered management.Gecilmara Salviato Pileggi; Vítor Alves Cruz; Ana Cristina de Medeiros-Ribeiro; Ana Karla Guedes de Melo; André Gustavo Cunha Trolese; Anna Carolina Faria Moreira Gomes Tavares; Zerbini, Cristiano Augusto de Freitas; Erika Biegelmeyer; Flávia Maria Matos Melo Campos Peixoto; Gilda Aparecida Ferreira; Joana Starling de Carvalho; Ketty Lysie Libardi Lira Machado; Lílian David de Azevedo Valadares; M. Pinheiro; NATALIA SARZI SARTORI; Priscila Dias Cardoso Ribeiro; Rejane Maria Rodrigues de Abreu Vieira; R. São Francisco Xavier; Sandra Lúcia Euzébio Ribeiro; Vanessa de Oliveira Magalhães; Viviane Angelina de Souza

2026-01-01https://doi.org/10.6084/m9.figshare.c.8317053.v1Figshare 20261Additional file 1 of Brazilian Society of Rheumatology – 2025 recommendations on vaccination in immune-mediated rheumatic diseasesSupplementary Material 1Gecilmara Salviato Pileggi; Vítor Alves Cruz; Ana Cristina de Medeiros-Ribeiro; Ana Karla Guedes de Melo; André Gustavo Cunha Trolese; Anna Carolina Faria Moreira Gomes Tavares; Zerbini, Cristiano Augusto de Freitas; Erika Biegelmeyer; Flávia Maria Matos Melo Campos Peixoto; Gilda Aparecida Ferreira; Joana Starling de Carvalho; Ketty Lysie Libardi Lira Machado; Lílian David de Azevedo Valadares; M. Pinheiro; NATALIA SARZI SARTORI; Priscila Dias Cardoso Ribeiro; Rejane Maria Rodrigues de Abreu Vieira; R. São Francisco Xavier; Sandra Lúcia Euzébio Ribeiro; Vanessa de Oliveira Magalhães; Viviane Angelina de Souza

Vaccination; Rheumatology; Epidemiology; MEDLINE; Rheumatoid arthritis; Medicine; Family medicine; Internal medicine

2026-01-01https://doi.org/10.6084/m9.figshare.31367670.v1Figshare 20261Assessment of the Effect of Various Teaching Strategies on Medical Students' Skills, Attitudes, and Comfort During Gynecological Examinations: A Randomized Controlled TrialINTRODUCTION: Few studies have evaluated the stress-related factors experienced by medical students during gynecological examination training or the effectiveness of different teaching strategies involving real patients. This study aims to assess the impact of 3 distinct instructional approaches, each incorporating a commercially available pelvic examination simulator, on medical students' clinical skills, attitudes, and comfort levels when performing gynecological examinations. METHODS: A total of 138 clerkship students received a commercially available pelvic examination simulator and were randomly assigned to the following interventions: reading a handout (reading), watching a video of pelvic examination on a pelvic model (model video), or watching a video of patient experience with pelvic examinations (testimonial video). Skill performance, measures of fear/anxiety/comfort, and overall satisfaction were assessed during both simulated and real patient encounters to evaluate the impact of each teaching modality. RESULTS: Mixed analysis of variance revealed statistically significant differences in all dependent variables for time (all P < 0.001) and for the time × group interaction on the Fear of Pelvic Examination Scale (F-PEXS) for discomfort ( P = 0.038). Post hoc analyses between subjects in the real-life environment revealed higher total F-PEXS ( P = 0.034) and F-PEXS discomfort ( P = 0.009) scores for the model video compared with reading and higher scores for the testimonial video compared with reading on the pelvic examination checklist ( P = 0.034). CONCLUSIONS: Despite good acquisition of skills, the model video group demonstrated greater fear of performing pelvic examinations. By contrast, the reading group exhibited the lowest acquisition of skills, but lower levels of fear. The testimonial video group exhibited good acquisition of skills and low fear levels. These findings support the ongoing discussion and potential implementation of brief, targeted educational strategies for teaching pelvic examination techniques.Luciano Fernandes Loures; Alessandra Lamas Granero Lucchetti; Sabrine Teixeira Ferraz Grünewald; Oscarina da Silva Ezequiel; G. M. Lucchetti

Randomized controlled trial; Dreyfus model of skill acquisition; Reading (process); Knowledge acquisition; Video recording; Testimonial; Medicine; Physical therapy; Physical medicine and rehabilitation

2026-02-20https://doi.org/10.1097/sih.0000000000000917Simulation in Healthcare The Journal of the Society for Simulation in Healthcare 20261Corrigendum to “Nasal microbiota and clinical features in acute flu-like illness: COVID-19 status and long COVID follow-up” [International Journal of Infectious Diseases 162 (2026) 108196 https://doi.org/10.1016/j.ijid.2025.108196]The authors regret that an error was identified in the Methods section of the article. Specifically, the subsection titles “Gut microbiota data processing” and “Gut microbiota analysis” are incorrect. Although the content of these sections is accurate, it refers to nasal microbiota, not gut microbiota.Carolina Alves Costa Silva; Adriele Pinheiro Bomfim; Julliane Dutra Medeiros; Jéssica de Jesus Silva; Ana Beatriz Cazé-Ceron; Thiago Cerqueira‐Silva; Ricardo Khouri; Aldina Barral; Manoel Barral-Netto; Gabriel da Rocha Fernandes; Cynara Gomes Barbosa; Viviane S․ Boaventura

Coronavirus disease 2019 (COVID-19); Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); 2019-20 coronavirus outbreak; Pandemic; Coronavirus Infections; Medicine; Virology; Intensive care medicine; Immunology; Infectious disease (medical specialty)

2026-02-20https://doi.org/10.1016/j.ijid.2026.108441International Journal of Infectious Diseases 20261PNEUMONIAS RELACIONADAS COM A ASSISTÊNCIA À SAÚDE: EPIDEMIOLOGIA, PATOGENIA, FATORES DE RISCO, EVOLUÇÃO, DIAGNÓSTICO, TRATAMENTO E PREVENÇÃOA pneumonia é a segunda infecção relacionada com a assistência à saúde mais comum no ambiente hospitalar e a primeira em UTIs. O objetivo do trabalho foi realizar uma revisão narrativa sobre pneumonias hospitalares. Realizou-se uma pesquisa bibliográfica sobre o assunto nos últimos 8 anos. Foram feitas consultas em livros, teses, dissertações, revistas científicas e artigos disponíveis em bases de dados como Scielo, LILACS, Pubmed, Medline, ScienceDirect que permitiram a obtenção de informações com enfoque na epidemiologia, patogenia, fatores de risco, evolução, diagnóstico, tratamento e prevenção das pneumonias relacionadas com a assistência à saúde. As pneumonias possuem incidência global, afetando predominantemente indivíduos do sexo masculino e aqueles com presença de comorbidades. Afetam indivíduos de todas as idades, com destaque para aqueles com mais de 50 anos e podem ser causadas por diversos micro-organismos, como Streptococcus pneumoniae, Pseudomonas aeruginosa, Acinetobacter baumannii, Staphylococcus aureus e enterobactérias, como Klebsiella pneumoniae, Escherichia coli, entre outros. O diagnóstico é clínico, radiológico e laboratorial e o tratamento é inicialmente empírico, com antimicrobianos de amplo espectro, até que haja resultado do teste de suscetibilidade aos antimicrobianos, momento em que é feito o descalonamento e a terapia antimicrobiana é dirigida para o micro-organismo isolado. A importância das pneumonias hospitalares, com destaque para as pneumonias associada à ventilação mecânica em UTIs, é clara, fazendo-se necessário mais e melhores estudos epidemiológicos, pesquisas sobre estratégias mais fáceis e de menor custo na sua prevenção, além da capacitação contínua dos profissionais de saúde, a fim de melhorar o prognóstico dos pacientes afetados.R. L. S. da Silva; Michel Rodrigues Moreira

Pneumonia; Staphylococcus aureus; Hospital-acquired pneumonia; Antimicrobial; MEDLINE; Klebsiella infections; Klebsiella; Medicine; Gynecology; Dermatology; Intensive care medicine; Pseudomonas aeruginosa; Streptococcus; Cross infection

2026-02-20https://doi.org/10.47820/recima21.v7i1.7401RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218 20261DETERMINANTS OF MOTOR COMPETENCE IN CHILDREN: ASSOCIATIONS WITH SOCIODEMOGRAPHIC, ANTHROPOMETRIC, AND BODY COMPOSITION FACTORSMotor competence (MC) can be defined as the level of skilled performance in different motor tasks. However, the influence of variables related to body composition and anthropometric measures has not yet been fully clarified. Therefore, the aim of this study was to evaluate the association between MC and sociodemographic, biological, and physical activity factors in children. This cross-sectional study was conducted with 172 children of both sexes, aged 6 to 10 years, from a municipal school. Motor competence was assessed using the Körperkoordinationstest für Kinder (KTK). Height, weight, waist circumference, leg length, foot length, and wingspan were measured. Body Mass Index (BMI) and waist-to-height ratio (WHtR) were calculated. Body composition was assessed by bioelectrical impedance analysis, providing body fat percentage, fat mass, and muscle mass. Bivariate and multivariate analyses were performed using Multiple Correspondence Analysis (MCA) and Multiple Linear Regression, with a significance level of 5%. The mean MC score was 42.66 (± 10.97) points. Significant associations were observed with age, body fat percentage, WHtR, leg length, wingspan, and participation in extracurricular physical activity. MCA indicated a moderate association between higher MC, older age, adequate body fat percentage, and physical activity practice. Multiple regression analysis demonstrated positive associations of MC with age, BMI, and wingspan, and negative associations with body fat percentage and waist circumference. It is concluded that motor competence shows independent associations with biological factors, especially age, wingspan, and body composition indicators. These findings reinforce the need for multifactorial approaches in the assessment and intervention of motor competence in children, considering sociodemographic, biological, and behavioral aspects.Marcio Vidigal Miranda; Naruna Pereira Rocha; Fernanda Martins de Albuquerque; Valter Paulo Neves Miranda; Maria Elisa Caputo Ferreira

Bioelectrical impedance analysis; Anthropometry; Competence (human resources); Waist; Body mass index; Bivariate analysis; Body fat percentage; Bayesian multivariate linear regression; Multivariate analysis; Psychology; Medicine; Physical therapy; Linear regression; Fat mass; Physical activity; Motor skill; Multivariate statistics; Regression analysis

2026-02-19https://doi.org/10.66104/0h68ct15Revista Multidisciplinar do Nordeste Mineiro 20261Abstract PS5-10-03: The Influence of Sociodemographic Factors on Barriers to Breast Cancer ScreeningAbstract Background: Identifying barriers to cancer screening is essential for developing effective strategies to enhance organized screening programs. Aims: This study aims to investigate the impact of sociodemographic factors on barriers to breast cancer screening in the state of São Paulo, a region marked by significant socioeconomic disparities. Methods: A cross-sectional study was conducted using a representative sample of women aged 50 to 69 years, who were users of the Brazilian Health System. Data were gathered through a semi-structured questionnaire designed to assess sociodemographic factors and barriers to breast cancer screening. The sociodemographic factors analyzed as independent variables included age group (50-59; 60-69); education (illiterate; elementary; high school; college graduate); income relative to the minimum wage (&lt;1 minimum wage; 1-2 minimum wages; ≥2 minimum wages); skin color (white; brown; black; yellow); employment status (employed; unemployed); type of employment (domestic work; private sector; public sector; employer; self-employed; unpaid worker); municipality of residence (Metropolitan Region of São Paulo; countryside 1; countryside 2); presence of chronic disease (yes; no); and health insurance (yes; no). Barriers to breast cancer screening were analyzed as dependent variables, grouped into six personal barriers (fear of diagnosis, embarrassment, other priorities, work schedule, pain, and forgetting to schedule) and four system-related barriers (difficulty scheduling the test, long wait time, distance to the screening facility, and difficulty obtaining results). These barriers were assessed through a 5-point Likert scale and logistic regression models were used to examine the relationships between the sociodemographic factors and cancer screening barriers. Results: The most common personal barrier to breast cancer screening was pain during mammography (59%), while the primary system-related barrier was long waiting times (44%). Regarding individual barriers, women with chronic diseases were more likely to fear discovering a serious issue (OR: 3.01; 95% CI 1.2-7.5). Residing in the metropolis was associated with higher odds of embarrassment (OR: 4.7; 95% CI 3.0-7.2) but showed an inverse relationship with pain (OR: 0.3; 95% CI 0.0-0.5). Women with brown and black skin were more likely to feel embarrassed during examination (OR: 2.5; 95% CI 1.2-3.6), while being employed was linked to forgetting to schedule the exam (OR: 3.3; 95% CI 2.1-5.9). Regarding system-related barriers, residing in the metropolis was associated with greater difficulty in scheduling a mammogram (OR: 2.7; 95% CI 1.3-5.8). Furthermore, employment status, having only elementary education, and being brown or black were linked to longer waiting times for results (OR: 3.0; 95% CI 1.5-7.1, OR: 2.9; 95% CI 1.3-6.3, and OR: 2.2; 95% CI 1.1-3.9). Conversely, employment status showed an inverse association with difficulty in scheduling a mammogram (OR: 0.4; 95% CI 0.1-0.7). Conclusion: Barriers to breast cancer screening differ based on sociodemographic factors. Brown or black skin color, residence in the metropolis, employment status, and chronic diseases were predictors of women-related barriers, while brown or black skin color, lower education levels, employment status, and living in the metropolis were predictors of system-related barriers. To improve mammography coverage and successfully implement an organized breast cancer screening program, it is essential to engage healthcare managers in developing key strategies to overcome these barriers. Collaborative efforts are crucial to ensure equitable access to screening and reduce disparities in breast cancer outcomes. These findings offer valuable insights for guiding the implementation of organized breast cancer screening programs in middle-income settings. Citation Format: A. B. Câmara, C. Luizaga, L. Cury, C. Carlos, R. López, A. Carvalho, B. Partha, W. Victor. The Influence of Sociodemographic Factors on Barriers to Breast Cancer Screening [abstract]. In: Proceedings of the San Antonio Breast Cancer Symposium 2025; 2025 Dec 9-12; San Antonio, TX. Philadelphia (PA): AACR; Clin Cancer Res 2026;32(4 Suppl):Abstract nr PS5-10-03A. B. Câmara; C. Luizaga; Lise Cury; C. Carlos; R. López; André L. Carvalho; B. Partha; W. Victor

Breast cancer screening; Breast cancer; Socioeconomic status; Cancer screening; Logistic regression; Marital status; Rural area; Likert scale; Family income; Medicine; Residence; Household income; Scale (ratio); Environmental health; Gerontology; Public health; Cancer; Health care; Demography; Disease; Family medicine

2026-02-17https://doi.org/10.1158/1557-3265.sabcs25-ps5-10-03Clinical Cancer Research 20261Teoria do Conhecimento em "O Nome da Rosa"O artigo trata das discussões a respeito da natureza e dos limites do conhecimento, conforme são abordadas no livro "O Nome da Rosa", de Umberto Eco.Luciano Caldas Camerino Camerino

Subject (documents); Context (archaeology); Action (physics); Perspective (graphical); Identity (music); Philosophy; Humanities; Epistemology

2026-02-20https://doi.org/10.5281/zenodo.18716172Open MIND 20261Teoria do Conhecimento em "O Nome da Rosa"O artigo trata das discussões a respeito da natureza e dos limites do conhecimento, conforme são abordadas no livro "O Nome da Rosa", de Umberto Eco.Luciano Caldas Camerino Camerino

Subject (documents); Context (archaeology); Action (physics); Perspective (graphical); Identity (music); Philosophy; Humanities; Epistemology

2026-02-20https://doi.org/10.5281/zenodo.18716173Zenodo (CERN European Organization for Nuclear Research) 20261Abstract PS5-10-17: Barriers to Breast Cancer Screening from the Perspective of Primary Care ProfessionalsAbstract Background: Cancer screening consists of the early detection of breast cancer in asymptomatic populations, with the goal of reducing disease-related mortality.Aims: This study aims to assess the knowledge and barriers to breast cancer screening from the perspective of primary care professionals, investigating associations between professionals characteristics, knowledge, and these barriers, with the goal of developing effective strategies to improve the screening program in the state of São Paulo, Brazil—a region marked by significant socioeconomic disparities. Methods: This cross-sectional study included a sample of 50 Primary Health Centers (PHCs) in the state of São Paulo. A population survey was conducted with a representative sample of 401 primary care professionals. Collected data include professional’s knowledge and characteristics, and barriers to breast cancer screening. These barriers were assessed through a 5-point Likert scale and associated with professionals’ characteristics and knowledge using multinomial logistic regression models. Interviews were conducted using a semi-structured questionnaire designed with RedCap™ software. Analyses were performed using the SPSS v.29 software. Results: Among the professionals interviewed, 82.8% are women and 52.9% are under the age of 44. A majority (88.2%) were employed in the health sector, with 32.6% working in nursing and 18.8% in medicine, while 11.8% held administrative positions. Only 60% were familiar with the guidelines for breast cancer screening and 64% were aware of the law ensuring cancer diagnosis within 30 days. Knowledge levels ranged from 37% to 89%, with higher awareness observed among nurses. From the professionals perspective, the most significant obstacle to breast cancer screening was long waiting times to undergo mammograms, reported by 35% of respondents. Other notable challenges included difficulties in verifying whether the target population was up to date with mammograms (33%) and excessive demand at the PHC (32%). These barriers were mainly reported by nurses, physicians, and professionals working in the Metropolitan Region of São Paulo. Importantly, knowledge on breast cancer guidelines showed an inverse association with the difficulty in informing the target population about the mammographic screening and its importance, while knowledge on cancer diagnosis legislation was associated with perceptions about long waiting times for screening and diagnostic procedures. Notably, 73% of professionals agreed that the absence of a health information system for screen women with abnormal test results compromises the effectiveness of breast cancer screening programs. Conclusion: The implementation of an organized breast cancer screening program requires strategic actions, specially aimed at reducing the long waiting times and ensuring the target population is up to date with the screening exam. These strategies may be tailored according to the professional role and geographic region of primary care. Furthermore, ongoing training to enhance the knowledge of both healthcare and administrative personnel is essential for addressing barriers to breast cancer screening—particularly those related to delays in screening and diagnosis. A robust and well-integrated information system is also critical to support the effective screening and follow-up of the target population. Collectively, these strategies are being undertaken to guide the establishment of an organized, sustainable, and population-based breast cancer screening program in São Paulo, Brazil. Citation Format: A. B. Câmara, C. Luizaga, L. Cury, C. Contreras, R. Lopes, A. Carvalho, P. Basu, V. Wünsch Filho. Barriers to Breast Cancer Screening from the Perspective of Primary Care Professionals [abstract]. In: Proceedings of the San Antonio Breast Cancer Symposium 2025; 2025 Dec 9-12; San Antonio, TX. Philadelphia (PA): AACR; Clin Cancer Res 2026;32(4 Suppl):Abstract nr PS5-10-17A. B. Câmara; C. Luizaga; Lise Cury; Carlos Alberto Huaira Contreras; Roberto Iglesias Lopes; André L. Carvalho; Pallavi Basu; V. Wünsch Filho

Breast cancer screening; Breast cancer; Cancer screening; Primary care; Likert scale; Logistic regression; Population; Cancer; Health care; Medicine; Family medicine; Nursing; Health professionals; Socioeconomic status; Scale (ratio); Primary health care; Multinomial logistic regression; Perspective (graphical); Gynecology

2026-02-17https://doi.org/10.1158/1557-3265.sabcs25-ps5-10-17Clinical Cancer Research 20261Exploring motor behavior through transcranial magnetic stimulation: a comprehensive tutorial from the neurobiomechanics and motor control perspectivesBackground: Transcranial Magnetic Stimulation (TMS) has emerged as a powerful tool for investigating motor behavior, primarily by analyzing the motor evoked potential (MEP) properties. Aim: This tutorial provides an integrated framework for understanding TMS from the neurobiomechanics and motor control perspectives. Method: We describe the role of surface electromyography (sEMG) in recording MEPs alongside protocols for electrode placement, the influence of whole and body parts in corticospinal excitability, principles of TMS instrumentation, neuronavigation techniques, robotics for precise TMS coil positioning, and TMS combined with electroencephalography (EEG). Conclusion: By integrating foundational concepts and practical guidelines on TMS applications – including MEP analysis, EEG integration, and neuronavigation – this tutorial provides researchers with a comprehensive framework for designing and interpreting studies effectively, thereby advancing the knowledge of motor control and biomechanics.Marco A. C. Garcia; Ana L. Y. De Nadai; Victor Hugo Moraes; Tiago S. Lopes; Thais C. Marchetti; Lucas Betioli; Victor H. Souza

Transcranial magnetic stimulation; Motor control; Electromyography; Robotics; Electroencephalography; Motor learning; Rehabilitation robotics; Neuronavigation; Psychology; Computer science; Neuroscience; Artificial intelligence; Physical medicine and rehabilitation; Human–computer interaction; Control (management); Neurorehabilitation

2026-02-20https://doi.org/10.20338/bjmb.v19i1.503Brazilian Journal of Motor Behavior 20261“Que só os casados possam entrar na governança das câmaras das vilas”:Este estudo faz parte de uma pesquisa mais ampla cujo objetivo é investigar as redes de alianças, o sistema de casamentos e os modos de transmissão patrimonial em Minas Gerais. A partir de um “exercício de micro-história” ou de um estudo de caso inspirado nessa metodologia, partimos de duas freguesias do termo de Mariana nas Minas Gerais no século XVIII, para discutir tanto os aspectos mais gerais e quantitativos sobre o sistema de casamentos, como também apreender a dinâmica de construção das redes horizontais e verticais de solidariedade na região. Especificamente neste artigo, nos concentraremos na análise do sistema de casamentos em São Sebastião, uma das freguesias que faz parte do estudo mais amplo, no período de maior dinamismo da atividade mineradora, ou seja, até a década de 1760. Faremos um corte mais verticalizado para explorar os matrimônios mistos entre mulheres forras e homens cativos e abordaremos os diversos enlaces matrimoniais ocorridos no interior de um grupo familiar da elite residente na região.Carla María Carvalho de Almeida

Order (exchange); Period (music); Work (physics); Humanities; Art

2026-01-01https://doaj.org/article/9c74ba84d439485db478503fb958cae9DOAJ (DOAJ: Directory of Open Access Journals) 20261Implementação de OKR na polícia federal: recomendações a partir do caso da superintendência de Polícia Federal em RondôniaEste relatório técnico analisa os desafios da implementação da metodologia OKR na Polícia Federal, focando especificamente no caso da superintendência de Rondônia. O estudo identifica uma lacuna entre a adoção formal do modelo e sua prática, marcada por uma gestão centralizada e metas que desconsideram as especificidades regionais da Amazônia. Entre os principais problemas apontados estão a falta de capacitação dos servidores e o excesso de indicadores, o que dilui o foco estratégico e gera retrabalho. Como solução, o autor propõe recomendações práticas, como a criação de objetivos táticos locais e o fortalecimento de ciclos de feedback mais participativos. O objetivo final é transformar o OKR em uma ferramenta de gestão real, promovendo maior engajamento institucional e eficiência operacional.Allan de Souza Ferreira Mattos; Nathalia Carvalho Moreira

Context (archaeology); Order (exchange); Term (time); Physics; Political science; Philosophy; Humanities

2026-02-21https://doi.org/10.5281/zenodo.18726629Open MIND 20261EditorialEditorial Locus Revista de História. V. 31 n. 1 Mirando o futuro É com satisfação que colocamos no ar o primeiro número do volume 31 da Locus: Revista de História. Neste número, o dossiê revisita os debates do colóquio que marcou as celebrações dos 20 anos do PPGH/UFJF e aprofunda as discussões nele presentes sobre a metodologia da micro-história, pensada em perspectiva global, a partir das noções de colonialidade e translocalidade. Traz também uma homenagem ao historiador Giovanni Levi e seu papel fundacional neste campo. Publicamos a conferência por ele proferida no colóquio e uma entrevista inédita então concedida a Mônica Ribeiro de Oliveira e Maíra Vendrame. Os organizadores do dossiê, Hevelly Ferreira Acruche e Robert Daibert Jr. introduzem a riqueza da discussão e o conjunto dos artigos em sua Apresentação. Confiram. Refletir sobre o caminho percorrido é atitude que mira o futuro. Neste número, celebramos também a crescente procura da revista, com artigos em estreito diálogo com a área de concentração e as linhas de pesquisa do Programa. A sessão livre vem densa e instigante. As discussões sobre patrimônio e arte se fazem presentes, honrando a tradição. O Patrimônio enquanto inconsciente da historiografia é o título do inspirador artigo de Rogério Mattos, sobre a necessidade de incorporar as novas construções e vivências do patrimônio de herança negra para a construção de uma agenda inovadora tanto na escrita como no ensino de história. Na sequência, Enrique Normando Cruz apresenta, em espanhol, o artigo Contexto y nuevos datos históricos acerca de un pintor al Noroeste del Río de la Plata (Jujuy, siglo XVIII), a partir de novas e originais informações sobre a obra e trajetória do pintor Diego de Aliaga. Transtemporalidade e o anacronismo das imagens: uma leitura possível da obra A imperatriz antropófaga, de Fernando Lindote, escrito por Rodolpho Bastos e Rafaela Barbieri, fecha o conjunto de reflexões neste campo, explorando o conceito de anacronismo das imagens de George Didi-Huberman e as contribuições sobre experiências temporais de Reinhart Koselleck, para explorar na tela de 2017 do pintor catariense Fernando Lindote, “as marcas da colonização, da resistência dos povos colonizados e de temporalidades antigas”. A política e os usos políticos do passado não poderiam estar de fora dos temas abordados nesta rica sessão livre. Partidos para quê? Quatro questões sobre os partidos políticos na Primeira República (1889–1930) de Surama Conde Sa Pinto abre a sequência em grande estilo, revistando o clássico tema das eleições e dos partidos políticos na Primeira Repúbica brasileira, em que a autora é reconhecida especialista. Continuando com temas clássicos da historiografia politica brasileira, A Classe Militar no século XIX: A imprensa como campo de discussão e definição da instituição militar de Fenanda de Santos Nascimento analisa o discursos dos periódicos militares brasileiros de 1850 a 1881, entendendo a imprensa militar do período como “canal de disseminação de ideias sobre o que é ser militar” em um momento em que ainda não se formara um discurso efetivamente institucional. Fechamos a trilogia com Paradoxos dos direitos humanos e a judicialização dos crimes da ditadura civil-militar brasileira (1973-2023), de Camila Cristina Silva, que aborda a contraditória história do terrorismo de estado na ditatura civil-militar brasileira como problema jurídico. Ainda não é tudo. Para concluir, retornamos à translocalidade como problema e fechamos com histórias africanas e latino-americanas, territórios fecundos da reflexão coletiva do PPGH/UFJF. Pastores africanos no horizonte da “ocupação” da Angola central: Ngulu, Keto e a expansão da missão congregacional (c. 1880-1900) , de Jéssica Evelyn Pereira dos Santos, aborda as primeiras missões protestantes estabelecidas na região de Angola Central a partir da trajetória de dois jovens que se tornaram pastores, professores e líderes comunitários. Por fim, Milton Ferreira Santos resenha o livro Historia mínima de las derechas latinoamericanas de Ernesto Bohoslavsky e Priscila Emanoeli Rodrigues Cozer a coletânea Os tempos da justiça: História, infâncias e direitos humanos na América Latina, organizada por Silvia Maria Fávero Arend e Humberto da Silva Miranda, ambos editados em 2023. Boa leitura! Hebe Mattos, editora Juiz de Fora, julho 2025Hebe Mattos

Context (archaeology); Theme (computing); Subject (documents); Interpretation (philosophy); Order (exchange); Humanities; Sociology; Philosophy

2026-01-01https://doaj.org/article/ba5d28eb73a54d75b22cf0d79ce9881eDOAJ (DOAJ: Directory of Open Access Journals) 20261As crencas e valores de Getulio Vargas e seus informantes na politica externa brasileira antes da Segunda Guerra MundialO artigo investiga os impactos das crenças e valores de Getúlio Vargas e de seus informantes no processo de formulação da política externa brasileira, sobretudo nos “bastidores da diplomacia”, entre 1934 e 1937. A investigação inspira-se nas propostas da História Transnacional e na Teoria das Elites, para analisar como o conjunto de crenças e valores do presidente e de sua elite de informantes relacionaram-se a decisões estratégicas e práticas diplomáticas confidenciais. A análise demonstra como a rede de informantes operava nos bastidores da diplomacia, oferecendo uma leitura não tradicional das relações exteriores brasileiras que antecederam a Segunda Guerra Mundial.Filipe Queiroz de Campos

Foreign policy; Hegemony; Politics; Elite; Face (sociological concept); Context (archaeology); Narrative; Political science; Humanities; Sociology; Gender studies

2026-01-01https://doaj.org/article/623e01c739784b47a32e558d3339bd4aDOAJ (DOAJ: Directory of Open Access Journals) 20261Celebrando a renovação!Editorial do Volume 31, número 2, 2025, da Locus: Revista de História (UFJF) Celebrando a renovação! É com senso de dever cumprido que apresento o segundo número do Volume 31 da Locus: Revista de História. O novo número é todo formado por artigos inéditos. O dossiê ora publicado, organizado por Ismara Izepe de Souza, do Departamento de Relações Internacionais da Universidade de São Paulo, e por Filipe Queiróz de Campos, pesquisador no Laboratório de História Política e Social do PPGH/UFJF e professor substituto no Departamento de História da mesma instituição, reflete sobre os 80 anos do final da Segunda Guerra Mundial, abordando o tema de uma perspectiva, ao mesmo tempo, global e latino-americana. Os artigos reunidos no dossiê “O Brasil, a América Latina e a Segunda Guerra Mundial” honram a tradição das linhas de pesquisa do PPGH/UFJF, em suas reflexões mais amplas sobre história global, saberes situados, história política e usos políticos do passado. Como sugerido pela capa, revisitar a Segunda Guerra a partir de um ponto de vista latinoamericano, é também revisitar as relações de poder entre os Estados Unidos e a América Latina. Um tema que não poderia ser mais atual. Convido os leitores a lerem a apresentação, escrita pelos organizadores, e a conhecerem os oito instigantes artigos nele reunidos. Três artigos avulsos fecham o volume, abordando temas clássicos de história política e da história social, também de uma perspectiva global e situada. O artigo “Os interesses do estado do Amazonas na Constituinte de 1890-1891”, de Geisimara Soares Matos, analisa a atuação política do Amazonas na elaboração da constituição de 1891. Em “O anarquismo italiano e a contrarrevolução preventiva: a análise de Luigi Fabbri sobre o fascismo”, Rafael Viana da Silva descortina o caráter pioneiro da análise crítica do fascismo italiano elaborada pelo pensador anarquista Luigi Fabri (1877-1935). Por fim, os sentidos das alforrias no processo de expansão escravista da cultura do cacau na Bahia da primeira metade do século XIX é o tema do artigo “Alforrias e libertos na ascensão da economia cacaueira de Ilhéus (BA), 1810-1850”, de Marcelo Loyola, Ivanice Ortiz e Raiza da Hora. Este editorial foi escrito e o presente número definitivamente fechado pela equipe de gerentes editoriais, eles próprios e suas equipes todos pós-graduandas e pós-graduandos do PPGH/UFJF, entre as festas de final de ano de 2025. Sem Ana Amélia Gimenez no controle do fluxo de artigos, Alina Nunes e Chrigor Libério na revisão editorial, Gabriel Machado na diagramação final, Jéssica Toledo no design gráfico e Joyce Mirella na coordenação de comunicação, ele não existiria. Com este segundo número de 2025, celebramos dois anos de trabalho conjunto e eu concluo meu período como editora da revista. Ao grupo de gerentes editoriais e às suas equipes, meu muito obrigado! Foi um trabalho gratificante. A partir do próximo número, minha colega Denise Nascimento assumirá a tarefa. Bem-vinda! A todos, boa leitura. Hebe Mattos,Hebe Mattos

Public figure; Politics; Spanish Civil War; Humanities; Philosophy; Political science

2026-01-01https://doaj.org/article/a1165604802a48e49bd48c668097a0fbDOAJ (DOAJ: Directory of Open Access Journals) 20261Implementação de OKR na polícia federal: recomendações a partir do caso da superintendência de Polícia Federal em RondôniaEste relatório técnico analisa os desafios da implementação da metodologia OKR na Polícia Federal, focando especificamente no caso da superintendência de Rondônia. O estudo identifica uma lacuna entre a adoção formal do modelo e sua prática, marcada por uma gestão centralizada e metas que desconsideram as especificidades regionais da Amazônia. Entre os principais problemas apontados estão a falta de capacitação dos servidores e o excesso de indicadores, o que dilui o foco estratégico e gera retrabalho. Como solução, o autor propõe recomendações práticas, como a criação de objetivos táticos locais e o fortalecimento de ciclos de feedback mais participativos. O objetivo final é transformar o OKR em uma ferramenta de gestão real, promovendo maior engajamento institucional e eficiência operacional.Allan de Souza Ferreira Mattos; Nathalia Carvalho Moreira

Context (archaeology); Order (exchange); Term (time); Physics; Political science; Philosophy; Humanities

2026-02-21https://doi.org/10.5281/zenodo.18726630Zenodo (CERN European Organization for Nuclear Research) 20261A posição brasileira no processo de negociação do Tratado sobre Empresas e Direitos Humanos das Nações UnidasA Resolução 26/9 (A/HRC/RES/26/9), assinada em 2014, estabeleceu o Grupo de Trabalho Intergovernamental Aberto sobre Corporações Transnacionais e outros Empreendimentos Comerciais em relação aos Direitos Humanos (OEIGWG), com o objetivo de desenvolver um instrumento vinculante sobre empresas transnacionais e direitos humanos no âmbito do Conselho de Direitos Humanos das Nações Unidas. O presente trabalho tem como objetivo analisar a posição da delegação brasileira durante as negociações do Tratado sobre Empresas e Direitos Humanos, confrontando essas posições com a legislação vigente no ordenamento jurídico brasileiro. A metodologia adotada envolveu a observação participante, por meio da inserção no Homa - Instituto Brasileiro de Direitos Humanos e Empresas, além da análise documental dos rascunhos do instrumento vinculante e dos relatórios das sessões de negociação, que são periodicamente divulgados pela ONU no site do Grupo de Trabalho.Manoela Carneiro Roland; Ana Laura Marcondes de Souza Figueiredo

Human rights; Work (physics); Social rights; Trade union; Political science

2026-01-01https://doaj.org/article/4da3037becef4dd0a0b958e85141ea01DOAJ (DOAJ: Directory of Open Access Journals) 20261Acesso ao diagnóstico da tuberculose na perspectiva das pessoas acometidas pela doença: um estudo transversalObjetivo: Identificar os aspectos que dificultam o acesso ao diagnóstico da tuberculose sob a ótica da pessoa acometida, na perspectiva de contribuir para a melhoria nas ações de controle da doença. Material e Métodos: Estudo transversal, de cunho avaliativo, constituído por 105 pessoas com tuberculose que realizavam as consultas de controle na Atenção Primária à Saúde e no Serviço de Referência Especializado de um município prioritário mineiro. Utilizou-se o instrumento PCATool-Tuberculose na versão dos doentes para a coleta dos dados e o resultado foi analisado no software R pela estatística descritiva de cada uma das variáveis referentes ao componente “acesso ao diagnóstico” do questionário. Resultados: O acesso ao diagnóstico apresenta fragilidades que se relacionam com questões do sistema de saúde e da pessoa acometida pela tuberculose, com o primeiro acesso e diagnóstico ocorrendo nos serviços de saúde de alta complexidade tecnológica, busca tardia para os cuidados com a saúde na percepção do adoecimento, dificuldades de identificação precoce dos sintomáticos respiratórios pelos profissionais de saúde, assim como sucessivas visitas aos serviços para conseguir atendimento e diagnosticar a doença. Conclusão: O acesso ao diagnóstico da tuberculose é influenciado não apenas por fatores organizacionais do sistema de saúde, mas também por determinantes individuais e sociais relacionados ao adoecimento. Esses aspectos revelam vulnerabilidades nos serviços de atenção à tuberculose, comprometendo o controle da doença. Diante disso, o fortalecimento da Atenção Primária à Saúde mostra-se essencial para enfrentar tais fragilidades e minimizar os impactos das desigualdades sociais sobre o cuidado ao doente. te.Angélica Aparecida Amarante Terra; Girlene Alves da Silva; Luciane Teixeira Passos Giarola

Work (physics); Control (management); Institution; Political science; Humanities; Medicine; Sociology

2026-01-01https://doaj.org/article/de04e84bef1443499ad5e75ccd9421c5DOAJ (DOAJ: Directory of Open Access Journals) 20261Accuracy of cone-beam computed tomography in detecting MB2 canals in maxillary molarsObjective: To evaluate the accuracy of cone-beam computed tomography (CBCT) in detecting second mesiobuccal (MB2) canals in maxillary first molars. Methods: A systematic review was conducted in accordance with PRISMA 2020 and registered in PROSPERO (CRD420251067699). Searches were performed in MEDLINE (via PubMed), BVS, LILACS, Cochrane Library, and Google Scholar for studies published between 2013 and 2025. Eligible studies included clinical trials, observational studies, systematic reviews, and meta-analyses evaluating CBCT for MB2 detection in maxillary first molars. Exclusion criteria were case reports, animal studies, and experimental models. Data extraction covered study design, population characteristics, imaging protocols, and MB2 prevalence. The certainty of evidence was assessed with the GRADE approach. Results: From 2,502 records, seven studies met the inclusion criteria. CBCT showed higher diagnostic accuracy than conventional radiographs, with MB2 prevalence ranging from 69.6% to 92%. No significant differences were found between right and left maxillary molars. Findings regarding sex and age were inconsistent, while ethnicity, Vertucci classifications, and inter-orifice distances were reported as influencing factors. Certainty of Evidence ranged from moderate to high. Final considerations: CBCT is a reliable and accurate tool for detecting MB2 canals in maxillary first molars, improving diagnostic capacity, treatment planning, and endodontic outcomes.Maria Clara Fernandes Ribeiro Dantas; Carine Carolaine Schmitz Barbosa; Ana Helena Alves de Castro Polisseni Cotta; Quézia Soares de Paula; Marcelo Tarcísio Martins

Cone beam computed tomography; Computed tomography; Population; Molar; Data extraction; Inclusion and exclusion criteria; Medicine; Orthodontics; Dentistry; Observational study; Diagnostic accuracy; MEDLINE

2026-02-21https://doi.org/10.25248/reas.e21944.2026Revista Eletrônica Acervo Saúde 20261DA FORMA AO PROCESSO: REFLEXÕES SOBRE BIOMIMÉTICA, MODELAGEM PARAMÉTRICA E IMPLICAÇÕES PROJETUAIS NO AMBIENTE CONSTRUÍDONo contexto do ambiente construído, a biomimética tem sido frequentemente incorporada ao projeto por meio de abordagens centradas na forma, o que limita sua compreensão como uma estratégia orientada por processos, guiada por desempenho, adaptação e organização sistêmica. Em resposta a essa lacuna, este artigo propõe uma reflexão teórica que desloca a biomimética da imitação morfológica para uma abordagem fundamentada em princípios funcionais, sistêmicos e adaptativos observados nos sistemas naturais. O objetivo é discutir como a modelagem paramétrica, articulada à Design Science Research (DSR), pode contribuir, em nível conceitual, para a tradução desses princípios em parâmetros e variáveis projetuais aplicáveis ao ambiente construído. Metodologicamente, a pesquisa adota a DSR como referencial epistemológico e analítico, posicionando-se nas fases iniciais de conscientização do problema e enquadramento conceitual, sem propor ou validar empiricamente artefatos. O estudo fundamenta-se em revisão crítica da literatura e na articulação conceitual entre biomimética, processos naturais e modelagem paramétrica, buscando evidenciar convergências relevantes para o campo do projeto. Como resultado, o artigo propõe um enquadramento teórico-metodológico que delineia caminhos conceituais para a operacionalização da biomimética como processo, destacando o papel da modelagem paramétrica na organização de relações, na exploração de variações e na simulação de comportamentos. Conclui-se que a abordagem proposta contribui para o debate teórico sobre biomimética e projeto, indicando implicações metodológicas e perspectivas futuras para investigações empíricas e abordagens computacionais emergentes no ambiente construído.Flávia Mattos; Ana Carolina Lacorte De Assis; Natália Fernandes da Motta; Ercília de Stefano; Marcos Martins Borges; José Alberto Barroso Castañon

Context (archaeology); Field (mathematics); Work (physics); Order (exchange); Philosophy; Humanities; Physics

2026-02-23https://doi.org/10.56238/arev8n2-106Aracê. 20261Por uma formação inicial de professores de valorização do contexto da prática docenteO presente texto apresenta como pano de fundo a importância da dimensão prática no processo de formação inicial de professores para atuar na educação básica. Discorre sobre o desequilíbrio na relação teoria-prática e a baixa efetividade dos estágios supervisionados observados nos cursos de Pedagogia, especialmente se comparados a alguns programas de iniciação à docência que, no Brasil, surgem para suprir essas fragilidades. São programas que têm conseguido agregar valor à formação inicial, mas que, por não operarem mudanças concretas na estrutura dos cursos, sinalizam para a urgência de que os estágios supervisionados sejam revistos e robustecidos com base em ações, como: a mobilização do professor da escola (supervisor) como co-formador dos futuros professores, o fomento de relações de parceria e diálogo entre professores (da universidade e da escola) e o planejamento de atividades e projetos que coloquem os licenciandos em contato direto com questões concretas do cotidiano escolar, sob orientação dos professores. São ações que buscam aproximar o conhecimento prático profissional do conhecimento acadêmico e reconhecer a co-responsabilidade dos atores envolvidos no processo formativo.Deniele Pereira Batista

Context (archaeology); Process (computing); Initial training; Humanities; Philosophy

2026-02-11https://doaj.org/article/7c85d6eda8e24f33b8881bb7d8fa659bDOAJ (DOAJ: Directory of Open Access Journals) 20261The impact of pulp disease on oral health-related quality of life in children aged 6 to 10 yearsOBJETIVES: To investigate the prevalence of pulp involvement and its impact on the quality of life of children aged 6 to 10 years. MATERIALS AND METHODS: Cross-sectional study with 363 schoolchildren. Were applied to children the “Child Perceptions Questionnaire” (CPQ 8–10), which assesses the impact of oral health on quality of life (OHRQoL). Oral clinical examinations were performed on the children to detect exposure of the dental pulp. RESULTS: Of the 363 children, 73 (28.2%) had at least one pulp-exposed tooth. There was an association between lower maternal schooling and the impact on OHRQoL, both for maternal schooling from 9 to 11 years of schooling (OR = 1.23; 95% CI: 1.00-1.51; p = 0.045) and for 8 years or less of schooling (OR = 1.26; 95% CI: 1.00-1.59; p = 0.045), compared to 12 years or more of maternal schooling. Children with pulp exposure were associated with an impact on OHRQoL model adjustment (OR = 1.49; 95% CI: 1.22–1.81; p < 0.001). CONCLUSION: The prevalence of pulp involvement in children aged 6 to 10 years was 28.2%. Children with pulp involvement had a worse perception of quality of life related to oral health, with an impact on emotional, social, and functional aspects, as well as limitations caused by oral problems. CLINICAL RELEVANCE: Epidemiological studies commonly address data on caries experience using the classic DMFT/dmft index, which records data on the average number of decayed, missing and filled teeth, but does not provide information on dental pulp exposure, which many It can sometimes have harmful consequences and can impact the quality of life related to oral health in children.Patrícia Gomes Fonseca; Maria Letícia Ramos-Jorge; Bianca Oliveira de Carvalho; Maria Eliza da Consolação Soares; Izabella Barbosa Fernandes

Oral health; Pulp (tooth); Epidemiology; Quality of life (healthcare); Disease; Perception; Medicine; Dentistry; Environmental health; Age groups

2026-02-23https://doi.org/10.1007/s00784-026-06770-6Clinical Oral Investigations 20261Usefulness of environmental DNA for Biomphalaria glabrata and Schistosoma mansoni surveillance and control of low schistosomiasis endemic areas in BrazilSchistosomiasis is a neglected parasitic disease that continues to affect hundreds of millions of people worldwide, particularly in developing countries. In Brazil, chemotherapy combined with access to safe water and improved sanitation has been effective in reducing the number of severe clinical cases. However, despite the current low endemicity, active transmission persists in several regions, where both infected individuals and the intermediate host , Biomphalaria glabrata , remain present. Therefore, more sensitive and scalable methods are needed to detect parasite dispersion and the presence of intermediate hosts in these areas. This study employed environmental DNA (eDNA) and real-time PCR (qPCR) to evaluate a molecular surveillance strategy for the detection of Schistosoma mansoni and B. glabrata in aquatic environments across municipalities in Minas Gerais, Brazil. Among 18 water sampling sites, S. mansoni and B. glabrata DNA were detected in 10 and 4 locations, respectively, with co-detection of both species in three municipalities. These findings highlight the potential of eDNA-based monitoring as a sensitive and non-invasive tool for environmental surveillance in low-endemicity settings. This approach can support more efficient management and control strategies for schistosomiasis. • An environmental DNA detection assay was developed for Schistosomiasis mansoni intermediate host in Brazil. • Detection of Schistosoma mansoni and its intermediate hosts is important for preventing the emergence of new schistosomiasis cases. • The newly designed technique was performed using water samples collected from different low endemic places from Brazil.Matheus Pereira de Araújo; Marcos José Marques; Raquel Lopes Martins Souza; Luiz Felipe Leomil Coelho; Masashi Kirinoki; Satoru Kawai; Áureo Almeida de Oliveira; Florence Mara Rosa; Megumi Sato; Megumi Sato; Marcello Otake Sato; Marcello Otake Sato

Biomphalaria glabrata; Schistosoma mansoni; Environmental DNA; Schistosomiasis; Sanitation; Biomphalaria; Schistosoma; Transmission (telecommunications); Biology; Sampling (signal processing); Intermediate host; Ecology; Zoology

2026-02-24https://doi.org/10.1016/j.meegid.2026.105911Infection Genetics and Evolution 20261A difícil acolhida do Pluralismo ReligiosoThis essay aims to present the steps that mark the recent ecclesial trajectory about the theme of interreligious openness. Taking as its starting point the path of dialogue that began with the Second Vatican Council (1962-1965), this reflection intends to follow the subsequent developments lived by the Catholic Church in this dialogical field. The proposal presented in this essay aims to show how, in much of its activity, the ecclesial community has remained hostage to a traditional axiom: extra ecclesiam nulla saluus (outside the Church there is no salvation). It will equally seek to point out recent theological developments that signal the affirmation of a pluralism of principle.Faustino Luiz Couto Teixeira

Dialogical self; Theme (computing); Religious pluralism; Pluralism (philosophy); Ecclesiology; Missiology; Point (geometry); Sociology; Theology; Epistemology; Reflection (computer programming)

2026-01-30https://doi.org/10.25247/2595-3788.2025.v8n2.p222-237Fronteiras - Revista de Teologia da Unicap 20261Dynamic State-of-Charge Modeling in Battery Energy Storage Systems With Power Ramp-Rate ControlThis paper presents a vectorized approach for modeling and tuning the state‑of‑charge (SOC) dynamics in Battery Energy Storage Systems (BESS) equipped with power ramp‑rate control (PRRC). The SOC evolution is formulated in discrete time, and parameter estimation is performed using Differential Evolution (DE) integrated with Anatem, a dynamic simulation tool used for electromechanical transient studies. The study compares the traditional generic (WECC‑based) SOC model, which employs a fixed‑gain integrator, with a proposed variable‑gain integrator that adapts to BESS active power through a piecewise‑linear function. The methodology is validated using real SCADA data from a 1.1‑MW photovoltaic plant coupled with a 0.95‑MW/0.49‑MWh BESS in Brazil. Measurements were sampled at 1‑second intervals, while Anatem simulations employed a 50‑ms integration step to ensure numerical accuracy and appropriate representation of converter‑level dynamics. A reference day and multiple operational scenarios were used for calibration and cross‑validation. Results show that the variable‑gain formulation reduces the Root Mean Square Error (RMSE) by 57–91% compared with the standard generic model, providing improved fidelity during rapid charge and discharge transitions. The method also enhances the alignment between simulated and measured active‑power behavior, supporting robust ramp‑rate compliance and improved representation of BESS operational limits. The proposed framework is suitable for both short‑term dynamic simulations and long‑term operational analyses and can be extended to hybrid configurations and other control functions requiring parameter tuning from real operational data. The findings highlight the importance of dynamic gain adaptation for accurate SOC modeling in hybrid PV–BESS systems and support the applicability of the method in stability studies, operational planning, and hybrid system design.André Fernando Schiochet; Gustavo Jacques Friedrich; João Alberto Passos Filho; Janaina Gonçalves de Oliveira

Integrator; Control theory (sociology); Battery (electricity); Stability (learning theory); Energy storage; Representation (politics); Power (physics); Photovoltaic system; Electric power system; Computer science; Control engineering; State of charge; Automatic Generation Control; Benchmark (surveying); Energy (signal processing); Control system; Calibration; Controller (irrigation)

2026-01-01https://doi.org/10.1109/access.2026.3666451IEEE Access 20261Role of Bi2O3 on structural and optical properties of Nd3+ doped boron-tellurite glassesÍcaro T. Lima; Felipe A. Carvalho; Meruva Reddy Sai Seshadri; R.T. Alves; Leandro S. Ávila; Leonarde do Nascimento Rodrigues; Maria Jose Bell; Virgílio de Carvalho dos Anjos

Bismuth; Band gap; Raman spectroscopy; Photoluminescence; Analytical Chemistry (journal); Indium; Luminescence; Doping; Attenuation coefficient; Refractive index; Materials science; Extrapolation; Absorption (acoustics); Laser; Boron; Chalcogenide; Phonon; Dopant; G band; Optoelectronics; Absorption spectroscopy; Excitation; Direct and indirect band gaps; 3D optical data storage; Atomic orbital; Atomic electron transition

2026-01-01https://doi.org/10.2139/ssrn.6295261SSRN Electronic Journal 20261Autoavaliação de cursos na pós-graduação: um estudo fundamentado na perspectiva de monitoramento de discentes e egressos do Mestrado Profmat da UFJFEste artigo tem como base uma pesquisa de mestrado profissional, cujo objetivo foi investigar o processo de autoavaliação de curso do Mestrado Profissional em Matemática em Rede Nacional (Profmat) da Universidade Federal de Juiz de Fora (UFJF), com foco no acompanhamento de discentes e egressos. O percurso metodológico adotado incluiu pesquisas bibliográfica e documental, pesquisa de campo, além de uma revisão de literatura sobre os eixos teóricos: autoavaliação, gestão participativa e monitoramento de discentes e egressos, ressaltando a importância da integração dessas práticas para a condução do processo de autoavaliação. Esse referencial subsidiou a análise dos dados produzidos por meio dos questionários aplicados a discentes, egressos e docentes do Profmat-UFJF. A pesquisa revelou, em grande parte, uma avaliação positiva da formação ofertada pelo curso, apontando oportunidades de aprimoramento relacionadas à gestão da autoavaliação e do monitoramento, à política de relacionamentos e ao projeto acadêmico do Programa. Como produto final, foram elaboradas propostas de intervenção direcionadas ao aprimoramento do processo de autoavaliação do curso, que contemplam a perspectiva de gestão participativa, com o olhar para o monitoramento de seus discentes e egressos.Flávia Barbosa Borges; Marco Aurélio Kistemann Junior; Juliana Aparecida Cantarino Toledo

Process (computing); Work (physics); Research methodology; Humanities; Psychology

2026-02-23https://doi.org/10.18675/1981-8106.v.36.n.71.s19415Educação 20261SMOKING, GENDER AND EDUCATIONThis article analyzes educational discourses and practices aimed at preventing smoking among adolescents, with an emphasis on gender relations. Based on a narrative literature review, studies published between 2022 and 2025 that address the interface between health, education, and youth were systematized. The results were organized into two categories: (1) educational strategies in the school and community context and (2) discourses and perceptions about smoking and gender. The analysis showed that educational actions focused on listening, dialogue, and intersectorality have a greater impact on the critical formation of adolescents. Furthermore, preventive campaigns still reproduce moralizing and stigmatizing discourses, especially directed at girls, which can compromise adherence to care practices. It is concluded that smoking prevention requires approaches sensitive to social markers, especially gender, promoting integrated, emancipatory educational practices connected to youth realities.Christiane Valéria Balbino Canuto; Ana Elisa de Oliveira Alho; Leônidas Nelson Martins Júnior; Thiago Resende da Silva

Compromise; Narrative; Context (archaeology); Perception; Narrative inquiry; Social environment; Sociology; Psychology; Gender studies; Pedagogy

2026-02-24https://doi.org/10.51249/gei.v7i01.2867Revista Gênero e Interdisciplinaridade 20261WOMEN'S HEALTH AND EDUCATIONThis article aims to analyze the interrelationships between women's health, educational practices, and public policies, based on a narrative review of academic productions published between 2022 and 2025. The research identified health education experiences aimed at different groups of women, considering markers such as territory, class, race, gender identity, and context of social vulnerability. The analysis of the texts allowed the construction of two thematic categories: (1) Health education as an emancipatory tool: women's voices, bodies, and practices; and (2) Challenges and invisibilities in public health policies for women in vulnerable contexts. The results demonstrate that health education, when guided by dialogue, active listening, and the valuing of popular knowledge, contributes to strengthening women's autonomy and protagonism. On the other hand, persistent limitations in public policies are evident, which still reproduce models centered on motherhood and neglect the diversities of gender, race, and territory. It is concluded that the effective implementation of comprehensive women's health care depends on the articulation between transformative educational actions, inclusive policies, and practices committed to equity and social justice.Beatriz Aline Ferreira Brito Rodrigues; Cristiane Teles Frazão; Bárbara Monique Alves Desidério; Letícia Araújo Ferreira Passos; Larissa Barbosa Santos; Brendha Daminelle Lima Cavalcante; Leônidas Nelson Martins Júnior

Autonomy; Transformative learning; Public health; Health care; Context (archaeology); Health education; Health policy; Narrative; Social determinants of health; Sociology; Public relations; Health promotion; Neglect; Equity (law); Public policy; Thematic analysis; Narrative inquiry; Health equity; Political science; Pedagogy; Psychology; Social policy; Articulation (sociology); Empowerment; Nursing

2026-02-24https://doi.org/10.51249/gei.v7i01.2869Revista Gênero e Interdisciplinaridade 20261HEALTH EDUCATION AND CARE PRACTICES IN THE CONTEXT OF PREVENTABLE DISEASESHealth education has become an essential strategy for tackling preventable diseases within the context of the Brazilian Unified Health System (SUS). This article presents a narrative literature review to analyze how educational practices have been mobilized as an instrument of care and prevention, especially in territories marked by social vulnerabilities. National studies published in the last ten years were analyzed, with an emphasis on intersectoral experiences, participatory methodologies, and pedagogical devices aimed at health promotion. The findings were organized into two categories: (1) health education and the prevention of preventable diseases in the SUS and (2) interfaces between public policies, territories, and care. It was observed that educational practices planned and sensitive to local contexts contribute to strengthening primary care, empowering individuals, and promoting health equity. However, challenges such as policy discontinuity, insufficient professional training, and fragmentation of actions still persist. It is concluded that health education, beyond the transmission of information, should be understood as a dialogical, emancipatory, and intersectoral process, capable of generating transformations in the living and health conditions of the population.Sthélio Freitas Macedo; Leônidas Nelson Martins Júnior; Jaqueline da Silva Izidoro; Uberlândia Islândia Barbosa Dantas de Meneses; Bruna Kelly Neto Santos; Annelissa Andrade Virgínio de Oliveira; Ana Lídia Coutinho dos Santos; Josefa Maria da Silva; Leila de Cássia Tavares da Fonsêca

Context (archaeology); Public health; Health education; Citizen journalism; Health care; Health policy; Narrative; Nursing; Medicine; Public relations; Narrative review; Political science; Health promotion; Social determinants of health

2026-02-24https://doi.org/10.51249/gei.v7i01.2873Revista Gênero e Interdisciplinaridade 20261Plural e compromissada com a justiçaO texto apresenta resultados de pesquisa sobre a teologia latino-americana das religiões, com um inventário das principais obras, autores e autoras que estão na gênese e no desenvolvimento dessa perspectiva teológica. Metodologicamente, os temas e visões foram agrupados em três eixos norteadores da pesquisa, a saber: (I) a importância pública das religiões para os processos de promoção da paz e da justiça, associada ao valor da mística e da alteridade na formação de espiritualidades ecumênicas; (II) a necessidade de mudança de lugar teológico a partir da realidade das culturas religiosas afro-indígenas; e (III) a contribuição da teologia feminista da libertação para o debate do pluralismo religioso. Entre os resultados obtidos destacam-se: (a) a constatação de que se fez necessária, para a teologia latino-americana das religiões, uma atenção especial à articulação entre a capacidade de diálogo dos grupos religiosos e os desafios em torno da defesa dos direitos humanos e da terra, pressupondo que a espiritualidade ecumênica requer visão dialógica, profunda sensibilidade com as questões que afetam a vida humana e inclinação para a promoção da justiça e da paz; (b) o reconhecimento de que a espiritualidade ecumênica que emerge do pluralismo religioso tem como valores a dimensão mística e a alteridade, e isso incidirá nos processos religiosos e sociais, favorecendo perspectivas utópicas, democráticas e doadoras de sentido; e (c) no caso da teologia cristã, é crucial destacar a centralidade do Reino de Deus como categoria fundamental no método teológico.Cláudio De Oliveira Ribeiro

Perspective (graphical); Plural; Field (mathematics); Historicity (philosophy); Alterity; Politics; Dimension (graph theory); Domain (mathematical analysis); Philosophy; Epistemology; Theology; Sociology; Humanities; Value (mathematics); Inequality

2026-01-30https://doi.org/10.25247/2595-3788.2025.v8n2.p238-264Fronteiras - Revista de Teologia da Unicap 20261Sociabilidades, sensibilidades e modernidade capitalistaA Cidade – assumida, vivenciada e compreendida por nós como lócus no qual se torna possível o engendramento de experiências, mesmo em meio a um tempo presente atravessado por inúmeras informações que rapidamente se convertem em esquecimentos – conectou, neste dossiê, pessoas de diferentes lugares e instituições.Maria Sílvia Duarte Hadler; Cyntia Simioni França; Sônia Regina Miranda

Field (mathematics); Interpretation (philosophy); Meaning (existential); Context (archaeology); Sociology; Humanities; Epistemology; Philosophy

2026-02-03https://doi.org/10.20396/resgate.v33i00.8682091Resgate Revista Interdisciplinar de Cultura 20261HUMAN CARE AND MENTAL HEALTH EDUCATIONThis article analyzes the relationships between human care, mental health education, and gender, based on a narrative review of scientific literature published between 2021 and 2024. The investigation focused on understanding how educational practices can contribute to mental health care, especially in contexts marked by social inequalities and marginalized subjectivities. The analysis of the studies resulted in two thematic categories: (1) Popular education and emancipatory care in mental health; and (2) Gender invisibilities and challenges to comprehensive care. The results show that educational practices sensitive to territory, listening, and diversity produce bonds and strengthen the autonomy of subjects experiencing psychological distress. On the other hand, the persistence of biomedical models and the neglect of social markers of difference hinder access to and effectiveness of care. It is concluded that mental health education should be understood as a political and pedagogical process, capable of mobilizing individual and collective transformations, provided it is supported by principles of equity, intersectionality, and social justice.Bárbara Monique Alves Desidério; Leônidas Nelson Martins Júnior; Sílvia Ximenes Oliveira; Douglas Bento das Chagas; Claudia Nunes Travassos Peixoto; Erivelto Ferreira de Oliveira; Bruna Amâncio Gondim

Mental health; Autonomy; Neglect; Health care; Narrative; Thematic analysis; Mental health law; Middle Eastern Mental Health Issues & Syndromes; Psychology; Mental health care; Diversity (politics); Sociology; Politics; Mental illness

2026-02-24https://doi.org/10.51249/gei.v7i01.2870Revista Gênero e Interdisciplinaridade 20261CHRONIC DISEASE AND HEALTH EDUCATIONThis article aims to discuss the training challenges faced by healthcare professionals in the care of people with chronic diseases, with an emphasis on promoting gender-sensitive educational practices. Based on a narrative literature review, studies published between 2023 and 2025 that address the interface between health education, professional training, social vulnerabilities, and care strategies in different territories were analyzed. The analysis highlighted two central categories: the need for critical and intersectional training, and the role of community spaces and digital technologies in mediating care. The results indicate that educational actions continue to be anchored in biomedical models, often disregarding gender inequalities and the sociocultural realities of those receiving care. Initiatives based on dialogue, listening, and valuing popular knowledge, as well as the use of media such as podcasts and discussion groups, proved effective in promoting autonomy and adherence to treatment. It is concluded that educational practices that incorporate intersectional and community perspectives are fundamental to building comprehensive, fair, and welcoming care for people with chronic diseases.Milene Izabel Pezarini Jiacon; Jéssica Barreto Pereira; Viviane Cristina Vieira da Silva; Suenny Alves dos Santos; Mayonara Fabíola Silva Araújo; Marília Andreza de Arruda; Leônidas Nelson Martins Júnior

Autonomy; Sociocultural evolution; Health care; Chronic disease; Narrative; Chronic care; Patient education; Health professionals; Community of practice; Medicine; Nursing; Sociology; Public relations; Inequality; Diversity (politics); Reflexivity; Medical education; Health education; Pedagogy; Professional development; Gerontology

2026-02-24https://doi.org/10.51249/gei.v7i01.2866Revista Gênero e Interdisciplinaridade 20261CHILDHOOD, GENDER, AND HEALTH PROMOTIONThis article analyzes the interfaces between childhood, gender, and health promotion through a narrative literature review, focusing on educational experiences aimed at comprehensive child care. Published works from 2020 to 2025 that address intersectoral actions in the field of health education, considering the child as a subject of rights and a producer of culture, were selected. The discussion was organized into two thematic categories: (1) intersectoral educational actions in child health promotion and (2) gender and childhood: stereotypes, vulnerabilities, and educational strategies. The results indicate that intersectoral educational practices sensitive to diversity generate positive impacts on children's autonomy, self-care, and socialization. Furthermore, they reveal that promoting health in childhood requires confronting gender stigmas present in educational and health institutions. It is concluded that comprehensive child care demands pedagogical strategies based on dialogue, active listening, and the valuing of differences, articulating education, health, and equity from early childhood.Taís dos Santos Leite; Andrea Cordeiro da Silva; Gabriela Neves Cavalcante Nascimento; Esther Pereira da Silva; Yolanda Abrantes Paletot; Leônidas Nelson Martins Júnior

Health promotion; Health care; Promotion (chess); Health education; Equity (law); Narrative; Health equity; Narrative review; Public relations; Economic growth; Political science; Nursing; Sociology; Health policy; Psychology; Diversity (politics); Thematic analysis; Public health

2026-02-24https://doi.org/10.51249/gei.v7i01.2868Revista Gênero e Interdisciplinaridade 20261NORMATIVIDADE CURRICULAR E FRAGILIDADES EPISTEMOLÓGICAS NA FORMAÇÃO INICIAL EM EDUCAÇÃO FÍSICAA Educação Física (EF) constitui componente curricular da Educação Básica e está inserida na área de Linguagens, Códigos e suas Tecnologias, conforme diretrizes estabelecidas pela Base Nacional Comum Curricular (BNCC). Este artigo examina a formação inicial de professores de Educação Física para compreender se e como os Projetos Pedagógicos de Curso (PPCs) expressam alinhamento com a concepção da Educação Física orientada pela área de Linguagens, Códigos e suas Tecnologias. Para tal demos ênfase à análise dos objetivos do curso e do perfil do egresso de Educação Física das instituições públicas de ensino superior do estado de Minas Gerais. Foram pesquisados dezoito PPCs divulgados nos sites oficiais dessas instituições em novembro de 2025. A análise documental foi a abordagem metodológica utilizada para tratar tais documentos. O estudo revelou que a inserção da formação inicial em Educação Física a área das Linguagens, Códigos e suas Tecnologias embora esteja formalmente assegurada na maioria dos PPCs, essa vinculação se apresenta frágil e pouco justificada do ponto de vista epistemológico nos objetivos e perfis do egresso analisados nos PPCs dos cursos.Ludmila Mourão; Ayra Lovisi Oliveira; Ronald Rodrigues Malaquias; Charles Willian da Silva Cruz; Geisiana Gonçalves de Almeida; João Vitor de Souza Moreira; Bárbara Aparecida Bepler Pires; Wilson Alviano

Humanities; Philosophy; Sociology

2026-02-23https://doi.org/10.51891/rease.v12i2.24253Revista Ibero-Americana de Humanidades, Ciências e Educação 20261DIABETES MELLITUS AND EDUCATIONAL TOOLS IN THE HEALTHCARE SYSTEMDiabetes Mellitus is one of the most prevalent chronic diseases in the Brazilian population, requiring effective educational strategies to promote self-care and quality of life. This article aims to analyze the use of pedagogical devices in the care of people with diabetes within the Brazilian Unified Health System (SUS), based on a narrative literature review. Eight articles published between 2018 and 2025 were selected, addressing experiences in health education, interdisciplinary practices, and pedagogical tools aimed at coping with the disease. The results were organized into two thematic categories: (1) health education and the strengthening of self-care in Diabetes Mellitus; and (2) pedagogical devices and the role of the SUS in continuing education. It was found that pedagogical devices – such as discussion groups, workshops, teaching materials, and digital technologies – contribute to the autonomy of users and the humanization of care. However, challenges such as the training of professionals, the valorization of educational practices, and institutional support still limit the reach of these strategies. It is concluded that the incorporation of pedagogical practices in diabetes care should be strengthened as a health promotion policy, in dialogue with the principles of popular education and the Brazilian Unified Health System (SUS).Sthélio Freitas Macedo; Suenny Alves dos Santos; Leônidas Nelson Martins Júnior; Jaqueline da Silva Izidoro; Samuel Guedes de Souza Araújo; Louise Passos Vigolvino Macêdo; Lúcia Gomes de Souza Silva

Autonomy; Health care; Healthcare system; Narrative; Coping (psychology); Thematic analysis; Health promotion; Health education; Medicine; Nursing; Medical education; Digital health; Promotion (chess); Quality (philosophy); Patient education; Diabetes mellitus

2026-02-24https://doi.org/10.51249/gei.v7i01.2872Revista Gênero e Interdisciplinaridade 20261Cosmic Strings and Negative $$\Lambda $$: Probing the Infant Universe in Einstein-Æther TheoryAbstract In this work, we analyze a quantized cosmological model within the framework of Einstein-Aether theory, with matter content described by a cosmic string fluid and the presence of a negative cosmological constant. The quantization is performed using the minisuperspace formalism with a perfect fluid via the velocity potentials approach, which allows for the interpretation of the fluid-associated variable as an internal time. The resulting Wheeler-DeWitt equation is solved, yielding normalizable eigenstates and associated wave packets. Employing both the many-worlds and the de Broglie-Bohm interpretations, we determine the dynamics of the scale factor and the behavior of the quantum potential. The results demonstrate the absence of singularities in our model, and the independence of the probability density with respect to the spatial curvature.A. Oliveira Castro Júnior; G. A. Monerat; F. G. Alvarenga; G. Oliveira-Neto; F. R. Manhães; E. V. Corrêa Silva; V. J. Monteiro; J. C. G. Tedesco

Minisuperspace; Cosmic string; Quantization (signal processing); Formalism (music); Gravitational singularity; String theory; COSMIC cancer database; Quantum cosmology; Universe; Physics; Quantum; Classical mechanics; Theoretical physics; Primordial fluctuations; Wheeler–DeWitt equation; String (physics); Mathematical physics; Eigenvalues and eigenvectors; Cosmological perturbation theory

2026-02-24https://doi.org/10.1007/s13538-026-02009-7Brazilian Journal of Physics 20261Ecologia, poder e mobilidade: operacionalizando a descolonização na prática psicológica através do modelo por capasEste ensaio teórico propõe que o Modelo Ecológico por Capas das Diretrizes Multiculturais da APA (2017) constitui um contexto operacional essencial para responder às críticas descoloniais e ao viés WEIRD na psicologia transcultural. Partindo do reconhecimento da diversidade cultural como realidade fundamental (Matsumoto & Juang, 2004), o artigo sintetiza as críticas ao extrativismo intelectual e à hegemonia ocidental no campo (Anjum & Aziz, 2024; Henrich et al., 2010). Argumenta-se que a reconceitualização do movimento humano como “mobilidade transcultural” (Cresswell, 2006; Abad, 2023) oferece um objeto de estudo mais fluido e adequado para o modelo. A análise demonstra como cada nível do modelo ecológico – da relação bidireccional (Nível 1) ao clima societal (Nível 4) – fornece um ponto de entrada concreto para aplicar princípios de justiça epistêmica, interseccionalidade (Crenshaw, 1989) e reflexividade crítica. Conclui-se que a integração consciente deste modelo com perspectivas descoloniais e o conceito de mobilidade possibilita uma prática psicológica verdadeiramente situada, capaz de intervir simultaneamente nas dimensões individual, relacional e estrutural do sofrimento e do bem-estar em contextos multiculturais.Alberto Abad; Luís Antônio Monteiro Campos; Ana Lucia Mendes Teixeira

Context (archaeology); Object (grammar); The Imaginary; Human being; Philosophy; Humanities; Epistemology; Sociology

2026-02-24https://doi.org/10.52641/cadcajv11i3.2127Cadernos Cajuína 20261PROFESSIONAL TRAINING IN HEALTH, GENDER, AND CAREProfessional health education faces significant challenges in addressing the complexity of care in contexts marked by social factors such as gender, race, class, and sexuality. This article presents a narrative literature review to analyze how training processes have (or have not) incorporated practices and knowledge geared towards comprehensive and equitable care. Based on the analysis of academic articles published between 2018 and 2023, two thematic categories were identified: (1) limitations and advances in health education focusing on equity and (2) care, identity, and the recognition of vulnerable populations. The findings highlight the persistence of traditional pedagogical models, with low inclusion of critical content on diversity and inequalities. In contrast, interdisciplinary experiences, participatory methodologies, and public policies focused on equity have emerged as promising strategies. It is concluded that overcoming inequalities in care necessarily requires critical, intersectional training committed to human rights and social justice.Leônidas Nelson Martins Júnior; Viviane Cristina Vieira da Silva; Marta Maria da Silva Lira-Batista; Emille Raulino de Barros; Damião Lucas Viana Roly; Nathan Santos de Oliveira

Equity (law); Thematic analysis; Health care; Inclusion (mineral); Citizen journalism; Health equity; Narrative; Social equality; Medical education; Psychology; Sociology; Public relations; Participatory action research; Social care; Professional development; Political science; Diversity (politics); Public health; Nursing; Public policy

2026-02-24https://doi.org/10.51249/gei.v7i01.2874Revista Gênero e Interdisciplinaridade 20261CONTRIBUTION OF CUMARU AND CASSAVA TO THE ECONOMIC VIABILITY OF AGROFORESTRY SYSTEMS IN THE EASTERN AMAZONAgroforestry systems (AFS) are composed of arrangements of species that allow for different productive strategies and augment the economy in rural properties and communities, such as in agrarian reform settlements, mainly in the Brazilian Amazon. In the cultivated spaces, it is possible to plan the staggering of production, as the system can consider plant and animal species to provide combinations of food, raw materials, and environmental services. In this work, the economic viability of two species in Agroforestry Systems in the Sustainable Development Project (SDP) Paraíso in Alenquer, in the state of Pará, was evaluated. Data were collected for the period from 2018 to 2021, calculating the following variables: revenues, costs/expenses, profit/loss, payback period, Net Present Value (NPV), Equivalent Annual Value (EAV), and Internal Rate of Return (IRR). All analyses were carried out considering this five-year time frame, showing that the highest profitability of cassava occurs in operations with scale for the production of flour, as well as gains from the sale of tonka bean or cumaru (Dipteryx odorata). The AFS are economically viable with high profitability in most productive arrangements. The low investment, flour sales strategies, and the high demand for tonka beans allow the producers to recoup investments in less than 8 months.Francisco Igo Leite Soares; Thiago Almeida Vieira; Marco Aurélio Oliveira Santos; Francisco Cleiton da Silva Paiva; Marilene Bizerra Da Costa; Kennedy Paiva Da Silva

Profitability index; Internal rate of return; Net present value; Production (economics); Payback period; Amazon rainforest; Agriculture; Raw material; Agrarian society; Agroforestry; Business; Agricultural science; Agricultural economics; Scale (ratio); Value (mathematics); Cash crop; Present value; Investment (military); Economics; Economic feasibility

2026-02-24https://doi.org/10.51249/gei.v7i01.2878Revista Gênero e Interdisciplinaridade 20261MANEJO TERAPÊUTICO DO BLOQUEIO ATRIOVENTRICULAR TOTAL (BAVT): ESTABILIZAÇÃO AGUDA E SUPORTE VITALO bloqueio atrioventricular total (BAVT) constitui uma condição clínica potencialmente grave, caracterizada pela dissociação completa entre atividade atrial e ventricular, podendo evoluir com instabilidade hemodinâmica e risco de morte súbita. Esta revisão narrativa teve como objetivo sintetizar evidências recentes acerca da etiologia, apresentação clínica, estratégias de estabilização aguda e manejo terapêutico do BAVT, com ênfase na identificação de causas reversíveis e nas indicações de suporte definitivo. Observou-se ampla heterogeneidade etiológica, com predomínio de casos idiopáticos em adultos jovens, embora distúrbios metabólicos, alterações eletrolíticas, isquemia miocárdica, sarcoidose e toxicidade medicamentosa também tenham sido descritos. Em pediatria, parcela significativa dos pacientes apresenta diagnóstico precoce e evolução assintomática inicial, porém com alta taxa de necessidade de implante de marcapasso ao longo do seguimento. A identificação de causas reversíveis, como intoxicação farmacológica ou inflamação miocárdica, mostrou impacto direto na conduta, podendo evitar a implantação definitiva do dispositivo. Na ausência de reversibilidade, o marcapasso permanente constitui a principal estratégia terapêutica, sendo a escolha da via de implante dependente de fatores clínicos e anatômicos. Entre as complicações tardias, destaca-se a cardiomiopatia induzida por estimulação ventricular direita crônica, com potencial indicação de terapia de ressincronização cardíaca. Conclui-se que o manejo do BAVT requer abordagem sistematizada, investigação etiológica criteriosa e individualização terapêutica, especialmente em populações jovens, nas quais a definição precoce da causa pode impactar significativamente o prognóstico a longo prazo.Fernando Malachias de Andrade Bergamo; Ryan Rafael Barros De Macedo; Felipe Ladeira Pereira; Nicoli Viana Alves; Felipe Diogo Pinto Mestrinho Pereira; João Pedro Santiago De Faria; Carlos Eduardo Rodrigues Nogueira; Thiago Rezende Rangel Rodrigues; Nicolas Schafer Vicente; Pablo André Brito de Souza; Alberto Cavalcante De Sousa; João Fernandes Floriano; Ana Cássia Silva Oliveira

Atrioventricular block; Myocardial ischemia; Tachycardia; Ventricular Repolarization; Medicine; Gynecology; Cardiology

2026-02-24https://doi.org/10.56238/levv17n57-079LUMEN ET VIRTUS 20261GENDER, EDUCATION AND POPULATIONS IN SITUATIONS OF SOCIAL VULNERABILITY AND THEIR ASPECTS OF HEALTH PROMOTIONThis article aims to analyze, through a narrative literature review, the interfaces between gender, education, and health promotion aimed at populations in situations of social vulnerability. The research was based on studies published between 2012 and 2023, encompassing educational experiences and public policies that address social determinants of health. The analysis revealed two main categories: (1) health education as an instrument of citizenship and resistance and (2) the invisibility of social markers and the limitations of public policies. The results indicate that educational practices guided by listening, territory, and intersectionality can strengthen the protagonism of marginalized subjects, expanding their access to rights and social participation. However, the persistence of biomedical approaches, intersectoral fragmentation, and the low critical training of professionals still limit the effectiveness of affirmative action policies. It is concluded that health promotion in contexts of inequality requires educational practices committed to social justice, equity, and the recognition of diversity.Leônidas Nelson Martins Júnior; Juliana da Silva Santos; Sílvia Ximenes Oliveira; Patrícia Trindade Benites; LUCAS KAYAN DE OLIVEIRA NASCIMENTO; Renata Corrêa Bezerra de Araújo

Intersectionality; Vulnerability (computing); Health promotion; Public health; Invisibility; Promotion (chess); Social determinants of health; Health equity; Action (physics); Public relations; Sociology; Political science; Citizenship; Social inequality; Social vulnerability; Health education; Narrative; Inequality; Racism; Psychology; Public policy; Social policy; Health policy

2026-02-24https://doi.org/10.51249/gei.v7i01.2871Revista Gênero e Interdisciplinaridade 20261AGING, GENDER AND CAREThis article aims to analyze educational processes focused on the care of older adults, emphasizing the intersections between aging, gender, and care, based on a narrative literature review. The research included eight published studies, selected based on their theoretical and empirical relevance. Data analysis identified two central thematic categories: (1) health education as a strategy for promoting active and participatory aging; and (2) gender inequalities and invisibilities that particularly impact older women in care settings. The results show that educational practices grounded in dialogue, intergenerationality, and the valuing of popular knowledge contribute to the autonomy and protagonism of older adults. At the same time, they point to the urgent need for public policies sensitive to gender issues and diversity in old age. It concludes that educational processes are powerful tools for building more equitable, humanized, and inclusive healthcare for the older population.Beatriz Aline Ferreira Brito Rodrigues; Éricles Dias Alves; Mariane Lorena Souza Silva; Eric Santos Santana; Marília Andreza de Arruda; Jordana Dayze de Carvalho Souza; Sabrina Regina Costa Moreira; Fransueide Sales de Medeiros; Denise Cristiane de Oliveira Onibeni; Leônidas Nelson Martins Júnior

Autonomy; Narrative; Older people; Thematic analysis; Citizen journalism; Health care; Diversity (politics); Inequality; Sociology; Participatory action research; Psychology; Narrative review; Grounded theory; Nursing; Gerontology; Medical education; Point (geometry); Public relations; Empirical research

2026-02-24https://doi.org/10.51249/gei.v7i01.2865Revista Gênero e Interdisciplinaridade 20261Metabolomic and transcriptomic effects of melatonin and gut microbiota through microbes and exosomes on muscle regeneration and enhancement of sports performance: a systematic reviewIntroduction: Sleep and recovery are essential for optimizing exercise performance. However, the effectiveness of melatonin supplementation in improving sleep quality and next-day physical performance remains uncertain. Research has demonstrated the ergogenic effect of melatonin (N-acetyl-5-methoxytryptamine) (MEL) in increasing exhaustive aerobic activity. Associated with the effects of MEL, adult tissue stem cells (mesenchymal stem cells) mediate homeostasis and regeneration of tissues and organs, integrating signaling cues and metabolic inputs with the release of exosomes and microRNAs to enhance athletic performance. Objective: It was demonstrated through a systematic review study the regulation of melatonin and gut microbiota by cellular and molecular metabolic pathways, such as microRNAs and exosomes, in the process of muscle regeneration and increased sports performance. Methods: The PRISMA Platform systematic review rules were followed. The research was carried out from July to August 2025 in the Scopus, Embase, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: A total of 136 articles were found, and 55 articles were evaluated in full and 29 were included and developed in the present systematic review study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 25 studies with a high risk of bias and 12 studies that did not meet GRADE and AMSTAR-2. Most studies showed homogeneity in their results, with X2=82.9%>50%. It was concluded that administering 6 mg of melatonin at night improved performance during high-intensity exercise the following day and enhanced perceived recovery up to 72 hours after exercise. Melatonin intake during training has beneficial effects on physical performance and protects tissues against the deleterious effects of reactive oxygen species and cellular damage. Furthermore, nocturnal melatonin supplementation during an athlete's intense training session alleviated oxidative stress, leukocytosis, and cellular damage, and improved performance recovery. Melatonin plays important roles in regulating the regenerative activities of mesenchymal stem cells, which, along with nutrients, modulate the activities of exosomes and microRNAs in the muscle regeneration process.Cristiano Villanova Andrade; Fernanda Assis Vianello Alvim; Francisco Alfredo Sampaio Cruz; Glauce Lippi de Oliveira; Isabele Helaine Rabelo Dias; Pablo Wanglon Richter; Cristina Moraes Osório Leite; Leonardo Vieira Lima; Vaneska Carvalho Bezerra de Brito; F Durante

Melatonin; Microvesicles; Gut flora; Metabolomics; Systematic review; microRNA; Transcriptome; Bioinformatics; Biology; Physiology; Regeneration (biology); Homeostasis; Medicine; Stem cell; Energy homeostasis; Cochrane Library

2026-02-24https://doi.org/10.54448/mdnt26s102MedNEXT Journal of Medical and Health Sciences 20261Associação dos sintomas da COVID-19 com o sexo e doenças crônicas não-transmissíveisO objetivo deste estudo foi analisar a relação de doenças crônicas não-transmissíveis (DCNT’s), sexo, e idade com sintomas prevalentes em indivíduos com COVID-19. Coletaram-se dados dos registros de participantes de um programa de extensão com testes de detecção molecular da COVID-19 de 2020 a 2023. O teste de chi-quadrado e o risco relativo foram utilizados para avaliar a associação das características individuais com a severidade dos sintomas (leves, moderados e graves), considerando p<0,05. Dos 9.371 participantes, a maioria era adulta e do sexo feminino. Sintomas leves da COVID-19 foram relatados por mais de 50% destes, enquanto sintomas moderados/graves por 45,4%. A maioria dos casos positivos com DCNT’s eram do sexo feminino, mas a gravidade dos sintomas mostrou associação com sexo masculino e hipertensão (p<0,05). O sexo masculino e hipertensão arterial foram características que representaram maior risco para desenvolver sintomas moderados/graves da COVID-19.Caroline Freitas Ochôa; Angela Giovana Batista; Daniel Ângelo Sganzerla Graichen; Fernanda Sarturi; Luiz Anildo Anacleto da Silva; Terimar Facin Ruoso

Disease; Incidence (geometry); Context (archaeology); Epidemiology; Depression (economics); Medicine; Gynecology

2026-02-25https://doi.org/10.17765/2176-9206.2026v19e13191Saúde e Pesquisa 20261A popularização da ciência em vídeos curtosEsta pesquisa exploratória, de natureza qualitativa e interpretativista, insere-se no campo da Linguística Aplicada e objetiva definir o vídeo-minuto de divulgação científica enquanto gênero de texto, a partir do levantamento de regularidades linguísticas e multimodais em exemplares desse gênero oral disponíveis no Youtube. Para tanto, lançamos mão de discussões teóricas pautadas em Bronckart (2004, 2006, 2008), Dolz e Schnewly (2004) e Marcuschi (2001, 2003), de modo a discutir o surgimento de novos gêneros de texto com o avanço tecnológico, em especial com o uso de redes sociais. Selecionamos para o corpus 10 vídeos, os quais foram analisados de acordo com o quadro teórico-metodológico do Interacionismo Sociodiscursivo. Foram identificadas regularidades que permitiram a construção de um modelo didático de gênero, o que pode contribuir tanto para a didatização deste gênero em sala aula, o que é previsto inclusive na Base Nacional Comum Curricular (BNCC), quanto para a divulgação científica em outros contextos de uso. Palavras-chave: Vídeo-minuto de divulgação científica; Modelo didático de gênero; Gênero de texto oral.Carolina Alves Fonseca; Poliana De Oliveira Cunha

Context (archaeology); Process (computing); Action (physics); Work (physics); Perspective (graphical); Field (mathematics); Domain (mathematical analysis); Computer science; Philosophy; Physics

2026-02-25https://doi.org/10.35499/tl.v19i2.24713Tabuleiro de Letras 20261Desafios e limites do plano Pena Justa para superação do estado de coisas inconstitucionalO artigo tem por objetivo apresentar uma análise inicial do Pena Justa — Plano Nacional para o Enfrentamento do Estado de Coisas Inconstitucional nas Prisões Brasileiras —, elaborado em cumprimento de decisão proferida pelo Supremo Tribunal Federal no âmbito da Arguição de Descumprimento de Preceito Fundamental 347. Após apresentar o processo de elaboração e estrutura do Plano, o artigo apresenta desafios para o cumprimento de seus objetivos.João Guilherme Leal Roorda; João Pedro Teixeira de Faria Viana; Igor Pereira de Paula

Work (physics); Meaning (existential); Subject (documents); Order (exchange); Political science; Philosophy; Humanities

2026-02-24https://doi.org/10.5281/zenodo.18644495Open MIND 20261A cosmologia africana em perspectivaAnalisamos, neste artigo, a cosmologia africana a partir da obra Mulungu (2007), do escritor moçambicano Adelino Timóteo, investigando como a espiritualidade, a morte e a magia se manifestam na construção simbólica da narrativa. Para tanto, através da análise crítica da obra, com suporte em referências teóricas sobre a espiritualidade, ancestralidade e cosmologia africana, exploramos as diversas maneiras como a morte é compreendida nas comunidades africanas, com destaque no papel dos espíritos na vida dos vivos. Doravante, analisamos a complexidade da magia no universo timoteano, destacando a importância da palavra e de amuletos na manipulação das energias. A pesquisa revela que a espiritualidade africana se materializa pela conexão entre os vivos e os mortos que vivem na dimensão transcendente, pois nas religiões tradicionais africanas a morte não simboliza o fim, mas a passagem para outras formas de vida. Por outro lado, ficou sugerido para nós, na narrativa, que a manifestação da magia depende das intenções de quem a usa, podendo ser para o bem ou para o mal, sendo movida e materializada por meio da palavra e de amuletos, que se configuram como objetos sagrados.Amosse Jorge Gelo; Tércia Costa Valverde

Humanity; Publish or perish; African culture; Humanities; Art

2026-02-25https://doi.org/10.35499/tl.v19i2.26088Tabuleiro de Letras 20261Desafios e limites do plano Pena Justa para superação do estado de coisas inconstitucionalO artigo tem por objetivo apresentar uma análise inicial do Pena Justa — Plano Nacional para o Enfrentamento do Estado de Coisas Inconstitucional nas Prisões Brasileiras —, elaborado em cumprimento de decisão proferida pelo Supremo Tribunal Federal no âmbito da Arguição de Descumprimento de Preceito Fundamental 347. Após apresentar o processo de elaboração e estrutura do Plano, o artigo apresenta desafios para o cumprimento de seus objetivos.João Guilherme Leal Roorda; João Pedro Teixeira de Faria Viana; Igor Pereira de Paula

Work (physics); Meaning (existential); Subject (documents); Order (exchange); Political science; Philosophy; Humanities

2026-02-24https://doaj.org/article/3c1b5c684f614f12a791a16a5fd7f79bDOAJ (DOAJ: Directory of Open Access Journals) 20261Market-Driven Transmission and Storage Co-Planning Expansion to Mitigate Market PowerThe restructuring of electric power systems has introduced challenges regarding the mitigation of market power, where network congestion can be strategically exploited to increase energy prices. This paper proposes a proactive approach for the Market-Driven Transmission and Storage Expansion Co-Planning (MD-TSECP), specifically designed to neutralize potential market power exercise. The formulation is presented as a bilevel stochastic optimization model where the upper level minimizes the total annualized investment costs and consumer payments, subject to a stringent constraint on the Average Nodal Price Deviation Index (ANPDI). The lower level simulates hourly electricity market clearing under diverse wind generation and load demand scenarios. To address the inherent non-convexity and NP-hard nature of the bilevel structure, a hybrid solution methodology is developed, coupling a Genetic Algorithm (GA) for discrete investment decisions with Linear Programming (LP) for operational market clearing. Numerical case studies on the modified IEEE 24-bus system demonstrate that the integrated expansion of transmission lines and Energy Storage Systems (ESS) reduces the total annualized expansion cost by 7.5% compared to traditional planning, while maintaining the same market competitiveness target (Ih≤ 0.20). The results conclude that the co-optimization of ESS and transmission assets effectively acts as a nodal price stabilizer, ensuring competitive energy pricing and enhancing overall social welfare in deregulated environments.Lucas Santiago Nepomuceno; Arthur N. de Paula; Edimar J. de Oliveira; L. E. G. de Oliveira

Electricity market; Bilevel optimization; Market clearing; Investment (military); Electric power system; Restructuring; Energy storage; Genetic algorithm; Electricity; Constraint (computer-aided design); Computer science; Mathematical optimization; Linear programming; Transmission (telecommunications); Demand response; Stochastic programming; Transmission system; Electricity generation; Optimization problem; Energy market; Spot market; Game theory; Electric power transmission; Peak demand; Nonlinear programming; Wind power

2026-01-01https://doi.org/10.1109/access.2026.3668111IEEE Access 20261Letter: Statins for Cirrhosis: Are we Ready to Move From Cardiovascular Prophylaxis to Portal Pressure Management? Authors' ReplyWe read with great interest the correspondence by Dr. Ismaiel [1] regarding our systematic review and meta-analysis [2]. We appreciate his thoughtful appraisal of the evolving role of statins in cirrhosis and his emphasis on the apparent discrepancy between the robust mortality benefit observed in our analysis, supported mechanistically by hepatic venous pressure gradient reduction, and the more conservative recommendations of current major guidelines [3, 4]. Dr. Ismaiel correctly highlights a key nuance in our findings: Although statin therapy significantly reduced all-cause mortality in randomised controlled trials (RCTs), the reduction in hepatic decompensation did not reach statistical significance within the RCT subgroup (odds ratio 0.75; 95% CI 0.52–1.09). He further raises the possibility that ‘healthy user bias’ in observational studies and differences in baseline disease severity may contribute to the apparent liver-specific benefits observed outside the randomised setting. To address this issue, we conducted a post hoc exploratory meta-regression restricted to RCTs, thereby minimising confounding related to treatment selection in observational data. We examined whether baseline disease severity, assessed using the study-level mean or median Model for End-Stage Liver Disease (MELD) score for the overall population, modified the treatment effect of statins. This analysis included six RCTs [5-10] reporting MELD scores, spanning a baseline severity range of approximately 6–15. For all-cause mortality, we observed no significant interaction between baseline MELD score and statin efficacy (Figure 1A; slope = 0.02; p = 0.851). This finding suggests the survival benefit observed in RCTs was consistent across the range of disease severity represented in these trials and was not driven solely by trials with lower MELD scores. Similarly, for hepatic decompensation, meta-regression showed no significant interaction with baseline MELD score (Figure 1B; slope = −0.09; p = 0.226), indicating the lack of statistical significance for this outcome in RCTs was consistent regardless of the average disease severity of the study populations. We acknowledge important limitations. This analysis is exploratory, includes a small number of trials and is inherently vulnerable to ecological bias and limited power; therefore, it cannot define an optimal ‘sweet spot’ for statin therapy across the full spectrum of cirrhosis. An individual patient data meta-analysis would be valuable to better delineate effect modification by disease severity, to account for competing risks and to more precisely characterise safety thresholds, particularly in patients with decompensated disease. Finally, we agree that safety remains central to cautious guideline recommendations as current evidence suggests that higher-dose vastatin in decompensated cirrhosis may increase rhabdomyolysis risk, supporting careful patient selection and conservative dosing regimens. In conclusion, although statins have not yet demonstrated a statistically significant reduction in hepatic decompensation in RCTs, the mortality benefit observed in randomised trials appears robust and not materially modified by baseline MELD score within the severity ranges studied. These findings reinforce the biological and clinical plausibility of statins as disease-modifying agents in cirrhosis, while underscoring the need for larger, long-term randomised studies to define their optimal and safest use. The authors' declarations of personal and financial interests are unchanged from those in the original article [2]. Bernardo de Faria Moraes: conceptualization, writing – original draft, formal analysis, methodology, data curation. Gustavo André Pedral Diniz Leite: investigation, writing – review and editing. Igor Boechat Silveira: investigation, writing – review and editing. Gabriel André Pedral Diniz Leite: investigation, writing – review and editing. Maria Luisa Motta Fonseca: investigation, writing – review and editing. Leonardo Corrêa Suffert: investigation, writing – review and editing. Luisa Medeiros Visentini: investigation, writing – review and editing. Luis Pedro Possapp Beis: investigation, writing – review and editing. Guilherme Grossi Lopes Cançado: conceptualization, supervision, data curation, writing – review and editing, methodology, writing – original draft, project administration. The authors have nothing to report. The authors nothing to report. Guarantor of the article: BFM and GGLC. The authors declare no conflicts of interest. This article is linked to Moraes et al. papers. To view these articles, visit https://doi.org/10.1111/apt.70526 and https://doi.org/10.1111/apt.70591. The data that support the findings of this study are available from the corresponding author upon reasonable request.Bernardo de Faria Moraes; Gustavo André Pedral Diniz Leite; Igor Boechat Silveira; Gabriel André Pedral Diniz Leite; Maria Luisa Motta Fonseca; LEONARDO CORREA SÜFFERT; Luisa Medeiros Visentini; Luis Pedro Possapp Beis; Guilherme Grossi Lopes Cançado

Blood pressure; MEDLINE; Disease; Clinical trial; Medicine; Intensive care medicine; Cardiology

2026-02-24https://doi.org/10.1111/apt.70599Alimentary Pharmacology & Therapeutics 20261pedrolugao/FittingAedes: Predictions of Aedes Dynamical Population - v2Second version of publishable code for the paper Spatial and temporal prediction of Aedes aegypti population with atmospheric and urban forms dependence. Accurately predicting mosquito population dynamics in cities requires models that couple climatic sensitivity with urban spatial heterogeneity. We developed a spatially explicit, climate-driven framework that integrates satellite imagery, field observations, and biology to simulate \textit{Aedes aegypti} dynamics across heterogeneous urban landscapes. A novel decomposition technique was introduced to disentangle entomological observations from mixed urban sites into landscape-specific time series for houses, streets, and parks. We provide a robust parameter estimation through a constrained inverse problem, revealing distinct temperature responses and biological processes across environments. Model validation against both egg and adult mosquito data from five Brazilian cities yielded strong correlations with the majority falling between $\rho$ = 0.4 and 0.8, confirming the model ability to reproduce observed spatiotemporal patterns. This integration of climate dependence, landscape quantification, and empirical validation provides a potential tool for anticipating mosquito abundance across space and time. By identifying periods and locations of elevated risk, the framework supports targeted, cost-effective interventions against dengue and other vector-borne diseases in a rapidly urbanizing and warming world.Pedro H. G. Lugão; Monalisa Silva; Raphael Cascelli; Grigori Chapiro

2026-02-25https://github.com/pedrolugao/FittingAedes/tree/v2.0.0Open MIND 20261Práticas com gêneros orais no métier docenteO presente artigo apresenta resultado de uma pesquisa cujo objetivo é analisar a presença de gêneros orais no trabalho de docentes de Língua Portuguesa do Ensino Fundamental II e Médio pelos quais eles interagem em práticas escolares. Compreendemos a importância das práticas orais profissionais na formação inicial para que, em sua futura atuação, os docentes possam realizar seu trabalho no campo escolar. Como referencial teórico, retomamos estudos sobre a formação para o agir profissional e os gêneros do métier docente, além de pesquisas que relacionam oralidade ao trabalho do professor. Quanto aos aspectos metodológicos, elaboramos entrevistas semiestruturadas com quatro professoras de Língua Portuguesa da educação básica, de diversas instituições de Minas Gerais. Após os dados serem gravados em vídeo, transcritos e analisados, os resultados revelam que as docentes interagem por variadas práticas orais em seu trabalho, mediadas pelos gêneros do seu métier, para as quais não foram preparadas, como a mediação de conflitos, as reuniões diversificadas e as orientações de estagiários, que requerem um discurso oral profissional específico. Consideramos que é necessário incluir reflexões explícitas sobre os gêneros orais do métier na formação inicial, haja vista a necessidade do domínio de um discurso oral para a docência.Joaquim Junior da Silva Castro; TÂNIA GUEDES MAGALHÃES; Pollyanne Bicalho Ribeiro

Work (physics); Subject (documents); Order (exchange); Discipline; Humanities; Sociology

2026-02-25https://doi.org/10.35499/tl.v19i2.24494Tabuleiro de Letras 20261Effect of intranasal detomidine in horses undergoing odontoplastyThis study aimed to evaluate the effects of intranasal administration of detomidine at a dose of 30 μg kg-1 in horses undergoing odontoplasty. Thirteen healthy, crossbred horses were used, and the following parameters were measured: heart rate (HR), respiratory rate (f), systolic arterial pressure (SAP), rectal temperature (RT), head height relative to the ground (HH), blood glucose (BG), intestinal motility (GI motility), sedation score, and the presence of upper eyelid and lip ptosis. Measurements were taken at baseline (M0) and at 10, 30, 60, 90, and 120 min after intranasal administration. Hematocrit (Hct) and leukogram (LEU) were evaluated at M30, M60, M90, and M120. Periodontal sensitivity was assessed at M30 and during the odontoplasty procedure (upper, lower, and incisor teeth), as well as at its conclusion. Statistically significant differences (p ≤ 0.05) were observed for HR, f, RT, Hct, WBC, HH, and GI motility. No significant changes were found in SAP or BG. All animals exhibited more pronounced sedation at M90. Periodontal sensitivity was detected in 69.23% of the animals, all of which responded to dental floating of the lower incisors. Intranasal detomidine at a dose of 30 µg kg-1 promotes mild sedation in horses, with a late onset and without clinically relevant cardiovascular changes, but is insufficient to allow periodontal procedures when used alone.Alline Morgana Silva Leite; Camille Alexandra Carvalho e Silva; Ianna Lins Teodoro Napoleão; Laura Bárbara Brito Cunha Lima; Ana Beatriz Oliveira Lara; Cândice Mara Bertonha; Joana Zafalon Ferreira

Detomidine; Sedation; Heart rate; Respiratory rate; Hematocrit; Blood pressure; Nasal administration; Medicine; Anesthesia; Premedication; Acepromazine; Respiratory system; Surgery

2026-02-19https://doi.org/10.5433/1679-0359.2025v46n6p1999Semina Ciências Agrárias 20261Combined spinal degeneration:Subacute combined degeneration (SCD) of the spinal cord is a rare neurological condition associated with cobalamin deficiency. We report the case of a 48-year-old man presented with sensory ataxia, pyramidal signs, and ineffective erythropoiesis secondary to hypovitaminosis B12. Spinal MRI revealed extensive hyperintensity in the posterior and lateral funiculi. Anti-parietal cell antibodies were positive, and upper endoscopy showed severe atrophic pangastritis, consistent with autoimmune atrophic gastritis. The investigation of hypoproliferative anemia, combined with dorsolateral spinal cord syndrome, allows for the consideration of SCD and should include the measurement of not only vitamin B12 but also more sensitive biomarkers, such as: homocysteine and methylmalonic acid. SCD should be included in the differential diagnosis of subacute spinal cord syndromes, as it is a potentially reversible condition with high morbidity.Gabriel Almeida Santos; Leandro Lima da Silva; Vinícius Neves Marcos; Giulia Balbi

Subacute Combined Degeneration; Spinal cord; Cobalamin; Vitamin B12; Hyperintensity; Intrinsic factor; Erythropoiesis; Hyperhomocysteinemia; Medicine; Pathology; Central nervous system disease; Cord; Spinal Cord Diseases

2026-02-25https://doi.org/10.46979/rbn.v61i4.68666Revista brasileira de neurologia 20261O ato de fotografar a vida da cidadeThis work seeks to reflect on the educational power of narratives from elderly people in Juiz de Fora, a city that became a reference for modernity in Between the 19th and 20th centuries. In this city, one particular photographer became known for capturing urban life and its ordinary practitioners through almost six decades: Jorge Couri. If, on one hand, listening to the voices of people who have experienced life in this city throughout decades leads us to observe both the singularity and the plurality of urban life, on the other, capturing this narrated time allows us to understand social processes that shape Social Memory in its conflicts, tensions and movements.Antônio Carlos Siqueira Dutra; Sônia Regina Miranda

Narrative; Active listening; Power (physics); Modernity; Social life; Work (physics); Ethnography; Sociology; Humanities; Gender studies; Aesthetics

2026-02-03https://doi.org/10.20396/resgate.v33i00.8679772Resgate Revista Interdisciplinar de Cultura 20261A esfera pública plataformizada: big techs, desinformação e a erosão democráticaEste artigo examina a reconfiguração da esfera pública no contexto da plataformização digital, analisando como o modelo de negócios das big techs e a mediação algorítmica intensificam a desordem informacional e representam uma ameaça à democracia deliberativa. Partindo do referencial teórico de Jürgen Habermas, o estudo adota uma abordagem qualitativa de revisão bibliográfica crítica para investigar a transformação do espaço público em uma arena fragmentada pela desinformação e polarização. A análise demonstra que a lógica de engajamento das plataformas, orientada por interesses econômicos, corrói as bases do debate democrático ao priorizar conteúdos viralizáveis em detrimento da precisão informativa e do pluralismo. Conclui-se que a erosão da esfera pública representa um esvaziamento substancial do regime democrático, uma vez que a desinformação, ao distorcer a realidade, paralisa o julgamento racional, corrompe o espaço público e fragiliza o vínculo entre cidadania e decisão política.Bruna De Oliveira Pereira; Wagner Silveira Rezende

Context (archaeology); Big data; Citizenship; Subject (documents); Computer science; Epistemology; Philosophy; Humanities; Pure mathematics

2026-01-14https://doi.org/10.12957/rqi.2025.94040REVISTA QUAESTIO IURIS 20261Conservative surgical approach for mandibular odontogenic keratocyst associated with guided tissue regeneration: a case reportOdontogenic keratocyst (OKC) is a cystic lesion with locally aggressive behavior and high recurrence rates, making treatment decisions complex. Conservative approaches have been proposed to preserve oral structures; however, few cases have reported their association with bone reconstruction. This report describes a pediatric case of extensive mandibular OKC managed conservatively with associated bone regeneration. An 11-year-old female patient presented with a radiographic finding of an extensive asymptomatic intraosseous lesion in the right mandible. Incisional biopsy and decompression device placement were performed, with initial diagnosis of dentigerous cyst. After six months, the device was replaced by a smaller one to promote bone neoformation. Nine months later, a second surgery was performed with device removal, extraction of teeth 47 and 48, and lesion enucleation. Histopathology confirmed OKC. At 28 months postoperatively, recurrence adjacent to the right first molar was detected, and a new conservative procedure was carried out, incorporating bone grafting with sticky bone. The patient was followed up for six months, showing absence of recurrence and graft healing. Despite initial misdiagnosis and multiple surgeries, conservative management preserved the stomatognathic system and avoided ablative procedures. Postoperative follow-up enabled early detection of recurrence and timely intervention associated with bone reconstruction.LAURA VIEIRA DE ALBUQUERQUE; Yuri de Lima Medeiros; Lívia Marques dos Santos; Kelly dos Anjos Melo Pereira; Bruno Augusto Benevenuto de Andrade; Daniel Amaral Alves Marlière

Keratocyst; Bone grafting; Asymptomatic; Lesion; Radiography; Biopsy; Conservative treatment; Decompression; Medicine; Surgery; Radiology; Odontogenic cyst; Mandible (arthropod mouthpart); Histopathology; Conservative management; Dentistry; Bone erosion

2026-02-20https://doi.org/10.5327/2525-5711.434JORDI - Journal of Oral Diagnosis 20261Structural and microvascular retinal changes following bariatric surgery: a prospective studyBACKGROUND: This study sought to evaluate structural retinal changes, mainly microvascular ones, in obese patients undergoing bariatric surgery. METHODS: Obese patients who were candidates for bariatric surgery at University of São Paulo Medical School Clinics Hospital were recruited. Each participant underwent ophthalmic evaluation with ultra-widefield retinography, optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) obtained within one month before and six months following the surgical procedure. Structural OCT parameters (subfoveal choroidal thickness, mean peripapillary nerve fiber layer thickness, central foveal thickness, and macular volume) and OCTA parameters (peripapillary vascular density, macular vascular density, area, perimeter and circularity of the foveal avascular zone - FAZ - of both superficial and deep vascular complexes) were calculated and compared. RESULTS: 42 participants were included (83.3% female, mean age 47 years) of whom 24 (57.14%) were diabetic and 18 (42.86%) were non-diabetic. Of this sample, 81 eyes were evaluated. Six months after bariatric surgery, a significant increase in central foveal thickness (from 258±26 μm to 260±25 μm, p < 0.001), macular volume (from 8.6 ± 0.4 mm³ to 8.7 ± 0.4 mm³, p < 0.001), peripapillary vascular density (from 63 ± 8% to 65 ± 8%, p = 0.003) and macular vascular density in the superficial (from 27 ± 4.7% to 28 ± 4.4%, p = 0.005) and deep vascular complexes (29 ± 3.9% to 31 ± 3.5%, p < 0.001) were observed. No significant changes were detected in the metrics of the FAZ, subfoveal choroidal thickness and mean peripapillary nerve fiber layer thickness. CONCLUSIONS: In this study, bariatric surgery was associated with improved retinal microvascular perfusion, as demonstrated by the increase in macular and peripapillary vascular density. The increase in central foveal thickness and macular volume may be secondary to improved microvascular perfusion.Lívia da Silva Conci; Leandro Bortolon Bissoli; Davi Paraguassu de Sousa Martins; Cleide Guimarães Machado; André Carvalho Kreuz; Rony Carlos Preti; Leonardo Proveti Cunha; Alexandre Grobbério Pinheiro; Marco Aurelio Santo; Mario Luiz Ribeiro Monteiro; Leandro Cabral Zacharias

Retinal; Nerve fiber layer; Prospective cohort study; Foveal avascular zone; Optic nerve; Optical coherence tomography angiography; Optical coherence tomography; Foveal; Medicine; Ophthalmology; Surgery; Perimeter; Visual acuity; Angiography; Fundus (uterus); Diabetic retinopathy

2026-02-26https://doi.org/10.1186/s40942-026-00819-0International Journal of Retina and Vitreous 20261Dental Care Access Among Children and Adolescents With Autism Spectrum Disorder: A Cross Sectional Survey in Juiz de Fora, BrazilABSTRACT Aims To investigate the conditions of access to dental care among children and adolescents with Autism Spectrum Disorder (ASD) in Juiz de Fora, Brazil, and to identify the main barriers faced by this population. Methods and Results This cross sectional study used a convenience sampling strategy. Data were collected from 130 parents or caregivers of children and adolescents with ASD through a structured questionnaire disseminated via institutions and digital platforms. The instrument was developed based on previous studies and reviewed by experts to ensure content validity. Descriptive analyses and Pearson's chi‐square ( χ 2 ) tests were performed. Most children with ASD (70.8%) had received dental care at least once, but 56.2% did not undergo regular follow‐up. The main barriers were difficulty finding specialized professionals (54.5%), financial constraints (42.0%), and behavioral limitations (23.9%). Younger children and those with higher family income, level 1 support, and verbal communication showed better adherence and behavior during dental care. Associations are reported without effect sizes or confidence intervals, as these analyses were not included in the study design. Conclusion Although most children and adolescents with ASD in Juiz de Fora had received dental care, ongoing barriers hinder consistent access, as identified through associative—not causal—relationships, given the cross sectional nature of the study. The shortage of specialized professionals, behavioral challenges, and financial difficulties remain major barriers to access. Early age, verbal communication, and higher family income were associated with, rather than predictive of, better access and adherence.Pedro Mattos Cardoso; Laís Canêdo Martins; Fernanda Campos Machado; Camila Faria Carrada; Flávia Almeida Ribeiro Scalioni

Cross-sectional study; Autism spectrum disorder; Autism; Economic shortage; Dental care; Psychological intervention; Medicine; Psychiatry; Psychology; Family medicine; Clinical psychology; Environmental health

2026-02-26https://doi.org/10.1111/scd.70158Special Care in Dentistry 20261LPG Humidity Sensor With Carbonyl-Rich Graphene-Oxide CoatingIn this study, we investigated the relative humidity (RH) sensor performance using long-period fiber gratings (LPG) covered with carbonyl-rich graphene oxide (CGO). The LPG was produced using the electric-arc-heating process on single-mode fiber (SMF-28). The CGO was synthesized utilizing changes in the Hummers technique, two oxidation processes, and extended oxidation periods. Furthermore, the humidity sensor was created by dip-coating the LPG active region of the fiber with CGO. As a result, we discovered that, when RH varies, the extremely hydrophilic CGO coating alters the effective refractive index of cladding modes. At room temperature (25°C), the sensor sensitivity was reported to be between 40% and 70% RH. High sensitivity (0.0153dB/%RH), good linearity (99%), and minimal hysteresis in the measured range were obtained. Given these considerations and the fact that RH sensors based on LPG coated with CGO are inexpensive, compact in size, have no electromagnetic interference, are easily integrated into remote sensing, and can be easily fabricated on large scales, this new sensor may be a promising technology for RH sensing.João Victor Bomtempo Castro; Anne Caroline Fernandes; Nayton C. Vicentini; Giovanni Romeu Carvalho; Cristiano Legnani; Alessandro Henrique de Lima; Renato L. Faraco; Felipe Oliveira Barino; Marcus Vinicius P. De Souza; Jonas H. Osório; Jefferson Esquina Tsuchida; Ulysses R. C. Vitor; Diogo V. N. Coelho; Welber G. Quirino; Alexandre Bessa dos Santos

Coating; Graphene; Cladding (metalworking); Oxide; Relative humidity; Refractive index; Hysteresis; Fiber optic sensor; Materials science; Optoelectronics; Humidity; Composite material; Optical fiber; Temperature measurement; Fiber; Atmospheric temperature range; Sensitivity (control systems); Linearity

2026-01-01https://doi.org/10.1109/access.2026.3668462IEEE Access 20261Política habitacional no Brasil: o direito à moradia sob a concretude das relações de poderPelo presente artigo busca-se realizar um levantamento histórico dos processos de criação e desenvolvimento da política habitacional no Brasil, a partir de quando ela foi formalmente pensada como política pública de Estado, desde a instituição do BNH, passando pelo Programa Minha Casa Minha Vida e pelo Programa Casa Verde e Amarela. A compreensão da política habitacional pela via de sua representação histórica, ajudou a delinear a complexa relação entre saber e poder atuantes nos modelos de uma prática que vem sendo redesenhada desde a metade do século XX em torno do argumento do déficit habitacional e da ideologia da casa própria. Numa articulação interdisciplinar que, além de jurídica, é histórica, social, econômica e filosófica, buscou-se compreender as condições permissivas pelas quais a política habitacional é uma produção de poder intimamente articulada com a noção de crise sintomatizada pelo déficit habitacional presente no país ao longo dos últimos 60 anos. Chegando ao seu objetivo final, o artigo problematiza, desde uma crítica arqueológica, a ancoragem da política de promoção de acesso à moradia à noção de crise permanente como uma constante histórica que a condiciona à imprevisibilidade da lógica econômica de custo-benefício na distribuição de recursos.Regina Lúcia Gonçalves Tavares

Power (physics); Context (archaeology); Economic shortage; Ideology; Humanities; Political science

2026-01-07https://doi.org/10.12957/rdc.2025.88323Revista de Direito da Cidade 20261Análise espacial da oferta da fisioterapia ambulatorial no sistema público do BrasilObjetivo: Identificar a presença de aglomerados assistenciais e diferenças conforme o porte populacional dos municípios e coeficiente de fisioterapeutas que atendem pelo SUS (CoFSUS). Métodos: Estudo ecológico com análise espacial de dados dos 5.570 municípios do Sistema de Informações Ambulatorias (SIA) e Cadastro Nacional de Estabelecimentos de Saúde do Sistema Único de Saúde (SUS) de 2024. Foram aplicados testes não paramétricos e análise de autocorrelação espacial para identificar padrões e aglomerados. Resultados: O registro do serviço de fisioterapia dos municípios do Brasil foi de 58,9% (3.281 municípios). Foi menor em municípios de pequeno porte I (47,1%), porém estes tiveram a melhor média [0,37 – DP (0,44)] e mediana 0,25 [Q1 (0,11)-Q3(0,48)] para o coeficiente de atendimento ambulatorial (CoA) Não foram encontradas diferenças nas comparações dos municípios pequenos com as metrópoles. Encontrou-se ínfima correlação (r=0,167, p<0,01) entre o CoA e CoFSUS por 1.000 habitantes dos municípios. A análise espacial mostrou correlação positiva fraca (Moran global=0,11) e aglomerados de vazios assistenciais. Conclusão: A oferta da fisioterapia ambulatorial no sistema público é assimétrica e não depende do porte populacional ou da proporção de fisioterapeutas que atendem pelo SUS.Peterson Marco de Oliveira Andrade; Otávio Amarante Cunha Acipreste; Charlene Rezende da Silva; Simone Lacerda Bispo; Leandro Roberto de Macedo; Fernanda de Oliveira Ferreira

Work (physics); Data collection; Population; Health care; Medicine; Humanities

2026-02-26https://doi.org/10.33448/rsd-v15i2.50710Research Society and Development 20261Measurements of differential cross-sections of WbWb production in the dilepton channel in pp collisions at $$ \sqrt{s}=13 $$ TeV using the ATLAS detectorA bstract At the Large Hadron Collider, the WbWb final state is expected to be dominated by $$ t\overline{t} $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mi>t</mml:mi> <mml:mover> <mml:mi>t</mml:mi> <mml:mo>¯</mml:mo> </mml:mover> </mml:math> production with a contribution from single-top processes. Differential cross-sections for WbWb production in the dilepton decay channel are measured at the particle level as a function of various kinematic variables. The analysis is based on data from proton-proton collisions at a centre-of-mass energy of $$ \sqrt{s}=13 $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msqrt> <mml:mi>s</mml:mi> </mml:msqrt> <mml:mo>=</mml:mo> <mml:mn>13</mml:mn> </mml:math> TeV, recorded by the ATLAS detector at the Large Hadron Collider over the period from 2015 to 2018, corresponding to an integrated luminosity of 140 fb − 1 . Measurements are performed within the fiducial phase-space defined by the presence of two b -jets and one electron and one muon of opposite charges. The differential cross-sections are corrected for detector effects and unfolded to the particle level. Results are compared with predictions from Monte Carlo event generators at next-to-leading order in perturbative quantum chromodynamics; overall the measurements are in reasonable agreement with several generator setups, although no single prediction is able to describe all measured distributions simultaneously. These measurements provide valuable constraints on the modelling of WbWb production and the interference between doubly resonant and singly resonant WbWb production.G. Aad; E. Aakvaag; B. Abbott; Sara Abdelhameed; Karin Abeling; N. J. Abicht; S. H. Abidi; Mohammed Aboelela; A. Aboulhorma; H. Abramowicz; Y. Abulaiti; B. S. Acharya; Alexander Ackermann; C. Adam Bourdarios; L. Adamczyk; S. V. Addepalli; M. J. Addison; J. Adelman; A. Adiguzel; Tim Adye; A. A. Affolder; Y. Afik; M. N. Agaras; A. Aggarwal; C. Agheorghiesei; F. Ahmadov; S. Ahuja; X. Ai; G. Aielli; A. Aikot; M. Ait Tamlihat; Brahim Aitbenchikh; M. Akbiyik; T. P. A. Åkesson; A. V. Akimov; D. Akiyama; N. N. Akolkar; S. Aktas; G. L. Alberghi; Jeffrey Ryan Albert; P. Albicocco; G. L. Albouy; S. Alderweireldt; Z. L. Alegria; Martin Aleksa; I. N. Aleksandrov; Călin Alexa; T. Alexopoulos; F. Alfonsi; M. Algren; M. Alhroob; B. Ali; H. M. J. Ali; S. Ali; S. W. Alibocus; M. Aliev; G. Alimonti; W. Alkakhi; C. Allaire; B. M. M. Allbrooke; J. S. Allen; Julia Frances Allen; P. P. Allport; A. Aloisio; Fernando Martín Alonso; C. Alpigiani; Z. M. K. Alsolami; A. Alvarez Fernandez; M. Alves Cardoso; M. G. Alviggi; M. Aly; Y. Amaral Coutinho; A. Ambler; C. Amelung; M. Amerl; C. G. Ames; T. Amezza; D. Amidei; B. Amini; K. Amirie; A. Amirkhanov; S. P. Amor Dos Santos; K. R. Amos; Dimitra Amperiadou; S. An; C. Anastopoulos; T. Andeen; J. K. Anders; A. C. Anderson; A. Andreazza; S. Angelidakis; A. Angerami; A. V. Anisenkov; A. Annovi; C. Antel; E. Antipov; M. Antonelli; F. Anulli; Mayumi Aoki; T. Aoki

Large Hadron Collider; Muon; Event generator; Detector; Atlas (anatomy); Hadron; Monte Carlo method; Luminosity; Muon collider; Physics; Particle physics; Nuclear physics; Production (economics); Pair production; Atlas detector; Collider; Differential (mechanical device); Generator (circuit theory); Channel (broadcasting); Standard Model (mathematical formulation); Electron; ATLAS experiment

2026-02-13https://doi.org/10.1007/jhep02(2026)153Journal of High Energy Physics 20261Effect of neuromuscular electrical stimulation associated with therapeutic exercise on pain, function, and strength of people with knee osteoarthritis: a systematic review with meta-analysis of randomized clinical trials with GRADE recommendationsObjective To determine whether NMES combined with therapeutic exercise improves pain, function, and muscle strength compared to exercise alone in adults with KOA.Methods We searched nine databases (PubMed, MEDLINE-Ovid, EMBASE, Cochrane Library, Web of Science, Scopus, SPORTDiscus, LILACS, SciELO) up to 5 April 2025. Randomized controlled trials comparing NMES + exercise with exercise alone were eligible. Two reviewers independently screened records, extracted data, and assessed methodological quality and risk of bias using the PEDro scale and the RoB 2. Random-effects meta-analyses generated mean differences (MD) or standardized mean differences (SMD). Certainty of the evidence was assessed with GRADE (PROSPERO CRD42023393616).Results Eight trials (354 participants; mean age ≈59 years; 71% women) were included. Immediately post-intervention, NMES + exercise did not reduce pain versus exercise alone (SMD −0.90, 95% CI −1.84 to 0.03; I2 = 84%). At 8–12 weeks, small benefits were observed for pain (SMD −1.30, 95% CI −1.87 to −0.73; I2 = 0%) and TUG (SMD −0.67, 95% CI −0.98 to −0.35). No differences were found for WOMAC total or quadriceps strength. Certainty was very low.Conclusions NMES + exercise may modestly improve long-term pain and mobility in KOA, though evidence certainty is very low.Andressa Costa da Silva; Geovanna Cândido Rafael; Rayane Quintão Castro; Priscila Monteiro Veras; Cyntia Pace Schmitz Corrêa; Jennifer Granja Peixoto; Fabiana Roberta Nunes Carnaúba; Marco Antônio Cavalcanti Garcia; Carla Malaguti; Diogo Carvalho Felício; Diogo Simões Fonseca

Randomized controlled trial; Clinical trial; Functional electrical stimulation; Muscle strength; Exercise therapy; Rehabilitation; Medicine; Physical medicine and rehabilitation; Physical therapy

2026-02-26https://doi.org/10.1080/09638288.2026.2633271Disability and Rehabilitation 20261Uso de impressão 3D em restauração do tipo endocrown após tratamento de lesão endoperiodontal: relato de caso com seguimento clínico de 3 anosObjetivo: Relatar um caso clínico de tratamento de lesão endoperiodontal, seguido de restauração endocrown com resina impressa e proservação de 3 anos. Detalhamento do caso: Paciente adulto do sexo masculino apresentava extensa lesão periapical, perda óssea alveolar e destruição coronária associada ao dente 44. A terapia endodôntica foi realizada durante 30 dias, com trocas semanais de medicação intracanal após instrumentação biomecânica inicial. Exames radiográficos mostraram regressão significativa da lesão, permitindo raspagens periodontais e controle contra a formação de biofilme. Um ano depois, foi realizada a restauração do tipo endocrown. Para tal, a seguinte sequência clínica foi adotada: preparo interno do espaço da câmara pulpar com broca 3131, preparo externo do término cervical em chanfro com broca 4138, acabamento do preparo, moldagem com silicone de adição, vazamento do modelo em gesso tipo IV, registro oclusal, restauração endocrown provisória em resina acrílica cor 66, escaneamento laboratorial dos modelos, planejamento digital da restauração e impressão em resina NanoLab (A2, Wilcos), seguida de cimentação resinosa autoadesiva. Considerações finais: A associação entre as terapias endodôntica e periodontal, seguida da reabilitação com endocrown impressa em resina, permitiu a preservação do dente 44 em função e estável na arcada, mantendo-se saudável após 3 anos de acompanhamento.Pillar Gonçalves Pizziolo; Bruna Cordeiro Cupertino; Sthéfane de Fátima Brito Francisco; André Luiz Moreira Souza da Silva; Vítor Knop Detoni; Anamaria Pessôa Pereira Leite; Laisa Araújo Cortinês Laxe

Silicone; Speech therapy; Computed tomography; Medicine

2026-02-26https://doi.org/10.25248/reas.e22603.2026Revista Eletrônica Acervo Saúde 20261Reconciling the role of ileal bile acid transporter inhibitors as symptom-directed therapy in primary biliary cholangitis: a focused meta-analysisIgor Boechat Silveira; Bernardo de Faria Moraes; Rodolfo Augusto Assis Rezende; Guilherme Grossi Lopes Cançado

Bile acid; Transporter; Primary (astronomy); Ursodeoxycholic acid; Bile acid malabsorption; Medicine; Pharmacology; Internal medicine; Gastroenterology; Ileum

2026-01-28https://doi.org/10.1097/meg.0000000000003108European Journal of Gastroenterology & Hepatology 20261Anti-CGRP monoclonal antibodies for chronic migraine with medication-overuse headache: a conservative meta-analysisChronic migraine (CM) is often complicated by medication-overuse headache (MOH), worsening disability. Although withdrawal of overused medications is recommended, adherence is poor and relapse is frequent. Monoclonal antibodies (mAbs) targeting the calcitonin gene-related peptide (CGRP) pathway may offer an effective preventive option without requiring discontinuation, but current evidence is limited by few and heterogeneous randomized controlled trials (RCTs).To systematically assess the efficacy and safety of anti-CGRP mAbs in treating CM with MOH (CM + MOH) under a conservative approach.The PubMed, Embase, and Cochrane Central databases were searched for RCTs comparing anti-CGRP mAbs with placebo in adults with CM + MOH. The primary outcome was the mean change in monthly migraine days (MMDs) at 3 months. The secondary outcomes included acute medication use, disability, drug overuse resolution, response rate, and adverse events (AEs). Random-effects models with Sidik-Jonkman estimator and Knapp-Hartung adjustments pooled effect sizes.We included seven RCTs, totalling 3,094 patients. Anti-CGRP mAbs significantly reduced MMDs (mean difference [MD] = -0.35; 95%CI: -0.43 to -0.26) and acute medication use (MD = -0.35; 95%CI: -0.51 to -0.19) compared with placebo. Higher rates, of ≥ 50%, of response (risk ratio [RR] = 1.94; 95%CI: 1.60-2.34) and drug overuse resolution (RR = 1.38; 95%CI: 1.04-1.83) were observed, with no significant increase in AEs (RR = 1.09; 95%CI: 0.85-1.40).Anti-CGRP mAbs were effective and well tolerated in CM + MOH, representing a viable alternative, especially for patients unable to discontinue acute medications. Further research should assess long-term outcomes and subgroup effects.Luana Miyahira Makita; GABRIELA DAS GRAÇAS DOS SANTOS CAROLINO; Yuri Gubitose de Souza; H. C. Brito; Mariana Oliveira; Giovana Schlichta Adriano Kojima; Milena Ramos Tomé; Júlia dos Santos Monteiro; Yasmin Bastos Faller; Élcio Juliato Piovesan; Mário Fernando Prieto Peres

Chronic Migraine; Placebo; Migraine; Adverse effect; Meta-analysis; Randomized controlled trial; Monoclonal antibody; Monoclonal; Medicine; Internal medicine; Drug; MEDLINE; Clinical trial; Placebo response

2026-02-27https://doi.org/10.1055/s-0046-1817018Arquivos de Neuro-Psiquiatria 20261Impact of ionic imbalances on rat cardiomyocyte function in pulmonary arterial hypertension: insights from energy dispersive X-ray spectroscopy and scanning electron microscopy analysisAbstract Calcium, sodium and potassium are essential for the contractile function of cardiomyocytes. In pulmonary arterial hypertension (PAH), intracellular calcium dynamics are impaired, affecting contractility and leading to heart failure. Energy-dispersive X-ray spectroscopy associated with scanning electron microscopy (EDS-SEM) technique can be useful for mapping the distribution of these minerals in cardiac tissue. This study aimed to investigate chronic ionic imbalances in the cardiac tissue of a monocrotaline (MCT) induced PAH model, using EDS-SEM, and to evaluate the impact of these imbalances on the contractile function of isolated RV myocytes. Twenty-eight Wistar rats were assigned to Control and PAH groups, with PAH induced by MCT. Right ventricular (RV) function was assessed by echocardiography at day 24. On day 25, cardiac tissue was analyzed by EDS-SEM to quantify electrolytes and by Western blotting, and RV myocyte contractility was measured. Student’s t-test was performed to compare the groups. Animals with PAH showed reduced final weight, increased cardiac and RV weight, and reduced RV systolic function compared to controls. EDS-SEM analysis revealed lower Ca and Na density in cardiac tissue of PAH animals. The expression of Ca 2+ regulatory proteins was reduced in the PAH group, and the contractility of isolated myocytes was impaired, exhibiting decreased amplitude, contraction velocity, and relaxation velocity. In conclusion, the study demonstrates that MCT-induced ionic imbalances, specifically reduced Ca and Na, disrupt excitation–contraction coupling proteins, leading to impaired cardiomyocyte contractility and contributing to the RV dysfunction observed in PAH.Leôncio Lopes Soares; Luciano Bernardes Leite; Bruno Rocha Avila Pelozin; Sebastião Felipe Ferreira Costa; Luiz Otávio Guimarães-Ervilha; Renê Chagas da Silva; Mariana Machado-Neves; Emily Correna Carlo Reis; Tiago Fernandes; Edilamar Menezes Oliveira; Antônio José Natali

Contractility; Myocyte; Contraction (grammar); Cardiac myocyte; Calcium; Cardiac function curve; Intracellular; Internal medicine; Cardiology; Chemistry; Biophysics; Pulmonary hypertension; Endocrinology; Medicine; Muscle contraction

2026-02-28https://doi.org/10.1007/s00421-026-06175-zEuropean Journal of Applied Physiology 20261Regional Variation in Congenital Heart Surgery in Brazil: A National Database AnalysisIntroduction: The absence of a congenital heart surgery national registry limits understanding of access, surgical volume, and mortality. This study analyzes the Brazilian administrative data to assess procedural distribution, outcomes, and regional disparities in congenital heart surgery. Methods: Retrospective analysis of the National Database (SIH/SUS) via DATASUS from January 2019 to December 2023. Ten benchmark congenital heart disease (CHD) surgeries were included. Admissions, in-hospital deaths, and mortality rates were extracted and stratified by region (North, Northeast, South, Southeast, and Center-West). Data were indexed per 100,000 live births using SINASC. Mann-Whitney and Fisher's exact tests were applied ( P -value < .05). Results: Of 9509 operations, the Southeast region performed 3661 (38.5%), followed by the South region (2261; 23.8%), then the Northeast (2.087; 22%), the Center-West (893; 9.4%), and the North region (607; 6.4%). Overall, in-hospital mortality was 6.4% (609/9509), with significant variation: 11.7% (105/893) in the Center-West and 11.2% (68/607) in the North versus 4.1% (86/2087) in the Northeast ( P -value < .0001). Mortality reached 24.6% (79/321) for transposition of the great arteries, 32.9% (24/73) for truncus arteriosus, and 60.4% 125/207) for the Norwood operation. Indexed by live births, the South performed up to 3 times more surgeries than the North. Conclusion: DATASUS National administrative data reveal significant disparities in access and outcomes for CHD surgery in Brazil, with mortality well above international benchmarks. Findings underscore the urgent need for investment in infrastructure, specialized workforce training, and creation of a national registry to improve equity and quality of care for children with CHDs.Leonardo Augusto Miana; Jeffrey P. Jacobs; Juan P.U. Passos; Marcelo B. Jatene

National database; Workforce; Heart disease; Equity (law); Mortality rate; Retrospective cohort study; Cardiac surgery; Medicine; Pediatrics; Heart defect; Database; Surgery

2026-02-27https://doi.org/10.1177/21501351261418275World Journal for Pediatric and Congenital Heart Surgery 20261OS MÉTODOS E ESTRATÉGIAS DE PREPARAÇÃO FÍSICA APLICADOS À LUTADORES DE DIFERENTES MODALIDADES ESPORTIVAS DE COMBATE: UMA REVISÃO NARRATIVA DE LITERATURAEsta pesquisa teve o objetivo de realizar uma revisão narrativa da literatura sobre os métodos e estratégias de preparação física aplicados a lutadores de diferentes modalidades esportivas de combate. Foi realizada uma revisão narrativa de literatura, utilizando os descritores e seus sinônimos: “Combat Sports”, “Physical Conditioning”, “Periodization”, “Sports Psychology”, “Physical Education and Training”. A busca foi realizada nas bases de dados Scholar Google e PubMed. Foram selecionados, os estudos que apresentaram os descritores e seus sinônimos ou no título ou no resumo do texto, de modo a contribuir para os achados sobre o tema desta pesquisa. 20 artigos foram inclusos nesta pesquisa. Com base nos artigos analisados, quatro grandes eixos temáticos foram estruturados, sendo: 1) As capacidades (bio)motoras na preparação física para lutadores; 2) A importância do profissional de educação física no planejamento da preparação física de lutadores; 3) A preparação psicológica, técnica e tática na preparação de lutadores; 4) Modelo de periodização na preparação física de lutadores. Conclui-se que a preparação física de lutadores é multifacetada, pois deve considerar capacidades motoras como velocidade, potência, força, agilidade, flexibilidade, coordenação motora, condicionamento aeróbio e anaeróbio. Além destes, considera-se aspectos técnicos, táticos, psicológicos, fisioterápicos e nutricionais. A atuação do profissional de educação física é essencial para garantir a avaliação, análise e organização adequada da preparação física do lutador. Neste processo o trabalho interprofissional é importante para garantir o desempenho atlético do lutador.Natalia Rodrigues dos Reis; Jefferson da Silva Novaes; João Vitor de Souza Moreira; Camille dos Reis Molina; André Calil e Silva; Guilherme de Jesus do Nascimento; Jeferson Macedo Vianna; Aline Aparecida de Souza Ribeiro

Context (archaeology); Domain (mathematical analysis); Quality (philosophy); Academic community; Humanities; Philosophy; Art

2026-02-27https://doi.org/10.66104/vqy4yz76Revista Multidisciplinar do Nordeste Mineiro 20261Horta- PáginaPara a primeira edição dessa horta-página, nosso espaço de plantar texto, propus que pudéssemos escrever de outras formas. Acredito que o como fazemos seja fundamental. Ensaio talvez fosse a categoria de texto mais próxima da liberdade oral que eu gostaria de chamar à nossa coletividade, que mais rimaria com aquilo que estamos criando e estudando. São ensaios experimentais, sobre nossas pesquisas, sobre nossas angústias de pesquisa, sobre as rotas coletivas que criamos, em devir, sobre as afetividades que existem quando se faz pesquisa no sul global, junto dos nossos territórios e viventes. Demarcamos politicamente nossas formas de fazer pesquisa, de construir conhecimento em partilha, em confluência, em atravessamento afetivo, de compor dobras, dobras e mais dobras, de inventá-las. Demarcamos sem pudor ou constrangimento. Não iremos disputar palavras que já nascem roubadas, definições científicas construídas sobre a égide da violência. Queremos outras palavras, outras formas, outras dobras, outras ciências, outras cons-ciências, outras rotasAna Carolina Pedrosa Pontes; Luiza Pedrosa Guimarães; Georgianna Gabriella Dantas; Farias Hannah Nunes; Thiago Novato; dos Santos Renata Tanan; Santana de Oliveira, Talbert Igor; Júlia Oliveira Rossatti; Anael Kaleu dos Santos Avelino

Intervention (counseling); Context (archaeology); Portuguese; Christian ministry

2026-02-28https://doi.org/10.5281/zenodo.18809648Zenodo (CERN European Organization for Nuclear Research) 20261Localized Vaginal Drug Delivery Using Chitosan Films Incorporating Mitracarpus frigidus Extract: From Physicochemical Design to In Vivo Antifungal EfficacyThayná Gomes Ferreira; Júlia Bertolini Fajardo; Mariana Hauck Vianna; Ana Bárbara Polo; Ari S.O. Lemos; Thalita de Freitas Souza; Lara M. Campos; Núbia Benini Andrade; Mariane Rocha Cordeiro Comitre; Lucas de Araújo Carvalho; Maria Clara Guedes; Emmilly de Oliveira Alves; Elaine Soares Coimbra; Gilson Costa Macedo; Renato Dantas-Medeiros; Luiz Fernando Cappa de Oliveira; Marcelo Gonzaga de Freitas Araújo; Guilherme Diniz Tavares; Thaís Nogueira Barradas; Ângelo Denadai; Rodrigo Furlan Silva Fabri

Thermogravimetric analysis; Zeta potential; Chitosan; Candida albicans; In vivo; Drug delivery; Antifungal drug; Particle size; Vulvovaginal Candidiasis; Chemistry; Controlled release; Matrix (chemical analysis); Antifungal; Drug; Biofilm; Fourier transform infrared spectroscopy; Antimicrobial

2026-01-01https://doi.org/10.2139/ssrn.6299555SSRN Electronic Journal 20261Horta- PáginaPara a primeira edição dessa horta-página, nosso espaço de plantar texto, propus que pudéssemos escrever de outras formas. Acredito que o como fazemos seja fundamental. Ensaio talvez fosse a categoria de texto mais próxima da liberdade oral que eu gostaria de chamar à nossa coletividade, que mais rimaria com aquilo que estamos criando e estudando. São ensaios experimentais, sobre nossas pesquisas, sobre nossas angústias de pesquisa, sobre as rotas coletivas que criamos, em devir, sobre as afetividades que existem quando se faz pesquisa no sul global, junto dos nossos territórios e viventes. Demarcamos politicamente nossas formas de fazer pesquisa, de construir conhecimento em partilha, em confluência, em atravessamento afetivo, de compor dobras, dobras e mais dobras, de inventá-las. Demarcamos sem pudor ou constrangimento. Não iremos disputar palavras que já nascem roubadas, definições científicas construídas sobre a égide da violência. Queremos outras palavras, outras formas, outras dobras, outras ciências, outras cons-ciências, outras rotasAna Carolina Pedrosa Pontes; Luiza Pedrosa Guimarães; Georgianna Gabriella Dantas; Farias Hannah Nunes; Thiago Novato; dos Santos Renata Tanan; Santana de Oliveira, Talbert Igor; Júlia Oliveira Rossatti; Anael Kaleu dos Santos Avelino

Intervention (counseling); Context (archaeology); Portuguese; Christian ministry

2026-02-28https://doi.org/10.5281/zenodo.18809649Zenodo (CERN European Organization for Nuclear Research) 20261Educação sexual e autonomia feminina: evidências de aprendizagem a partir de uma intervenção pedagógicaEnsinar sexualidade é uma tarefa complexa, pois envolve fatores culturais, sociais e religiosos que moldam as percepções dos indivíduos sobre o tema. Considerando esses obstáculos, este estudo analisou a implementação de uma sequência didática estruturada em metodologias ativas, com enfoque no ciclo menstrual e no uso da pílula anticoncepcional, visando promover a aprendizagem significativa e fomentar a autonomia das estudantes. A sequência didática foi aplicada para alunos do 1º ano do Ensino Médio durante as aulas de Biologia e organizada em módulos sequenciais que articularam problematização, investigação e reflexão crítica. A avaliação da aprendizagem, realizada por meio de instrumentos diagnósticos antes e após a intervenção, evidenciou avanços expressivos: houve aumento de 40,1% nas respostas corretas e redução de 27,1% nas respostas incorretas. Os resultados indicam que a abordagem adotada potencializa a compreensão conceitual e contribui para a formação crítica dos alunos, reforçando a relevância da educação sexual como prática emancipatória no espaço escolar.Jayme Rosignoli Júnior; Patrícia E. de Almeida

Interpretation (philosophy); Autonomy; Relation (database); Affect (linguistics); Perspective (graphical); Reading (process); Subject (documents); Context (archaeology); Psychology; Social psychology; Epistemology; Set (abstract data type)

2026-03-02https://doi.org/10.1590/scielopreprints.15188 20261Microstrip T-Resonator: Review, Design, and Error Assessment for Dielectric CharacterizationThis paper presents a comprehensive study of the Microstrip T-Resonator (MTR) for dielectric characterization of PCB substrates. Due to conflicting assumptions in available models, we evaluate two Microstrip T-Resonator (MTR) configurations: MTR-S (Short Substrate), without substrate extension beyond the stub, and MTR-E (Extended Substrate), with substrate extension beyond the stub. Microstrip discontinuities, particularly the open end, significantly affect dielectric characterization. Specifically, the effective length used for relative permittivity extraction relies on an open-end correction derived for extended substrates, making MTR-E the appropriate choice for this parameter. Loss tangent estimation, in turn, depends on radiation loss models that assume the substrate terminates at the open end of the resonator, as in the MTR-S configuration. Thus, this work investigates the MTR methodology and the effects of substrate extension on dielectric characterization accuracy. Relative permittivity and loss tangent are estimated using measured and simulated data, and the results are employed to assess the error and deviation of each configuration. The analysis highlights that aligning device geometry with model assumptions significantly improves estimation accuracy, particularly for loss tangent, which exhibits greater variation with substrate termination.Lucas D. Coelho; Marcelo E.V. Segatto; Álvaro A. M. De Medeiros; Ulysses R. C. Vitor

Microstrip; Dissipation factor; Dielectric; Permittivity; Dielectric loss; Characterization (materials science); Relative permittivity; Materials science; Substrate (aquarium); Tangent; Approximation error; Scattering parameters; Optoelectronics; Electronic engineering; Extension (predicate logic); Optics; Computer science; Reduction (mathematics); Work (physics); Computational physics

2026-01-01https://doi.org/10.1109/access.2026.3669383IEEE Access 20261EDUCAÇÃO INCLUSIVA E DIVERSIDADE: DESAFIOS E REPRESENTATIVIDADE NO ESPAÇO ESCOLARA educação inclusiva enfrenta barreiras estruturais e culturais persistentes que impactam a equidade no cenário educacional brasileiro. Este estudo, configurado como um ensaio teórico fundamentado em uma revisão integrativa da literatura, analisa as práticas pedagógicas e as políticas públicas voltadas à diversidade. O objetivo central é investigar como a representatividade e a sensibilização docente atuam como catalisadores no fortalecimento de uma escola efetivamente inclusiva. A metodologia seguiu o protocolo de seis etapas para revisões integrativas, garantindo o rigor e a rastreabilidade dos achados. A análise demonstra que a inclusão transcende a mera presença física do aluno com deficiência, exigindo a eliminação de barreiras atitudinais e arquitetônicas. Os resultados sugerem que a vantagem pedagógica reside na "engenharia de inclusão": transformar a diversidade em um ativo de aprendizagem coletiva, sustentada por uma governana educacional robusta. Conclui-se que a representatividade nos materiais didáticos e a formação continuada são pilares indispensáveis para a construção de um ambiente escolar que respeite as trajetórias individuais e promova a emancipação social.Jeovane Soares Rodrigues; Francisco das Chagas de Mesquita Costa; Francisca Gecielma de Oliveira Torres; Andréa Aparecida de Souza Alves; Flavia Patrícia Martins Ferreira; Luciane Batista Teixeira; Mirella Claudino Oliveira Silva; Cristina Hill Fávero

Work (physics); Control (management); Physics; Humanities

2026-03-02https://doi.org/10.66104/awn1kw76Revista Multidisciplinar do Nordeste Mineiro 20261The hazing gap: The concealed burden in Brazilian medical schools and the need for validated assessment toolsThe university learning environment plays a crucial role in shaping students’ mental health and overall well-being. Although these settings are often associated with personal and academic growth, they can also expose students to conditions that contribute to psychological distress1. Recent evidence shows that certain aspects of college life, especially in medical schools, are linked to high rates of anxiety and depression among medical students. Factors such as academic pressure, performance demands, and the broader institutional culture help explain these findings2,3. For newly admitted students, these factors are predominantly linked to the process of entering a new environment. The transition into university often involves seeking belonging within groups such as sports teams, student organizations, and residence communities4. Initiation rituals are part of this integration process and can range from welcoming and harmless to violent and abusive5. These violent and potentially abusive practices are collectively known as “hazing”, which includes various forms of violence, such as gender or racial violence, bullying, and institutional violence6.Euripedes Constantino Miguel; Giancarlo Lucchetti; Rodolfo Furlan Damiano; Clarissa Garcia; Laura Fernandes Berto; Rodrigo Hadade; Juliane Piasseschi de Bernardin Gonçalves; Bianca Besteti Fernandes Damiano; Elizabeth J. Allan; David Kerschner; Oscarina da Silva Ezequiel; Alessandra Lamas Granero Lucchetti; Lisabeth F. DiLalla; Homero Vallada

Mental health; Anxiety; Depression (economics); Suicide prevention; Process (computing); Residence; Poison control; Human factors and ergonomics; Psychology; Medical education; Social psychology; Occupational safety and health

2026-02-04https://doi.org/10.11606/issn.1679-9836.v104iesp.e-243104Revista de Medicina 20261EFICÁCIA E SEGURANÇA DE PRÓTESES CONTROLADAS POR MICROPROCESSADOR EM AMPUTADOS TRANSFEMORAIS: UMA REVISÃO SISTEMÁTICA DE ESTUDOS CONTROLADOSEsse artigo buscou avaliar a eficácia e segurança das próteses controladas por microprocessador em pacientes com amputação transfemoral unilateral (UTA). Métodos: Foi conduzida uma revisão sistemática seguindo as diretrizes PRISMA, com busca nas bases de dados Medline/PubMed, Cochrane e Embase. Foram incluídos 16 estudos, dos quais 11 eram ensaios clínicos randomizados. Resultados: As MPKs demonstraram superioridade em diversos testes de mobilidade, com significância estatística (p < 0,05) em testes como TUG e 10MWT, além de reduzir quedas, melhorar a qualidade de vida e promover maior satisfação em relação à prótese, também com significância estatística, particularmente em pacientes MFCL K2 e K3. Além disso, demonstrou-se que indivíduos com menor mobilidade podem se beneficiar mais do C-Leg® e Kenevo®, enquanto aqueles em faixa etária mais baixa e maior mobilidade podem se beneficiar mais com o Genium®. Conclusão: As MPKs proporcionam benefícios funcionais e de segurança em pacientes com amputação transfemoral, especialmente nos níveis K2 e K3. O Genium® parece mais adequado para pacientes mais jovens e ativos, enquanto o C-Leg® oferece uma boa relação entre funcionalidade e segurança.Hugo Lorran Souza Costa; Bárbara Morando Kalil Patrício; Bruno Ribeiro de Lima; Breno Alves de Souza Vaz

Context (archaeology); Quality (philosophy); Balance (ability); Value (mathematics); Medicine; Philosophy; Gynecology

2026-03-02https://doi.org/10.51891/rease.v12i3.24712Revista Ibero-Americana de Humanidades, Ciências e Educação 20261Influence of carbohydrate on the microparticulation process of whey proteins: structural modifications and indicators of the Maillard ReactionWith the growing demand for lactose-reduced foods, the development of versatile ingredients has gained prominence. This study evaluated the production of microparticulated whey proteins (MWP) with lactose (WL), glucose, and galactose (WGG) or without added carbohydrates (WOC), maintaining 6% protein. Structural modifications were analysed by particle size, sedimentation, chromatography, hydrophobicity, and sulfhydryl groups, in addition to the quantification of Maillard reaction markers. The samples presented similar size distribution and thermal denaturation, indicating a standardized process. The absence of carbohydrates preserved sulfhydryl groups, which may affect stability. Hydrophobicity correlated with changes in secondary structure. Among the Maillard markers, lysine, carboxymethylysine, and pyrraline remained stable; however, furosine and dicarbonyl compounds were higher in MWP-WGG due to the presence of glucose and galactose. Lactulose appeared only in products with lactose. The results indicate that the presence of carbohydrates, rather than their type, influences microparticulation, making MWP-WGG a promising ingredient for reduced-lactose products.Igor de Paula; Natalia Casas Mesa; Alan Frederick Wolfschoon-Pombo; Uwe Schwarzenbolz; Thomas Henle; Ítalo Tuler Perrone; Luiz Fernando Cappa de Oliveira; Rodrigo Stephani

Maillard reaction; Lactose; Lactulose; Carbohydrate; Galactose; Polysaccharide; Chemistry; Food science; Xylose; Chromatography; Whey protein; Glycation; Ingredient; Amadori rearrangement; Organic chemistry; Biochemistry

2026-03-03https://doi.org/10.1016/j.idairyj.2026.106615International Dairy Journal 20261Prioritizing neglected food species in nutritional studies using expert-knowledge and explainable AIFood biodiversity is vital for human health and the development of sustainable food systems. However, research on neglected and underutilized species is limited by funding, uneven research capacity, and the challenge of balancing ecological, cultural, and public health considerations, requiring innovative prioritization approaches. Using Brazil as a model, this study inventories 369 neglected food species across algae, aquatic fauna, wild terrestrial vertebrates, insects, mushrooms, and plants. A mixed-methods approach, combining expert knowledge and explainable AI (LightGBM and SHAP value analysis), identified key factors for prioritizing species for food composition and consumption studies. The inventory is dominated by plants (29.5%) and wild vertebrates (24.4%), with significant gaps in nutritional data, particularly for algae, insects, and wild vertebrates. Over 36,000 recipes using neglected species were identified. In both food composition (R2: 0.677) and consumption studies (R2: 0.782), recipe number and species occurrence across different states were the most influential features in predicting prioritization. These findings emphasize the role of cultural uses and local accessibility in shaping nutritional research priorities. We urge increased research on neglected species to bridge data gaps and integrate them into food systems, promoting sustainable diets in Brazil and other tropical regions.Michelle Cristine Medeiros Jacob; Aline Martins de Carvalho; Angela Giovana Batista; Aníbal de Freitas Santos Júnior; Antonio Augusto Ferreira Carioca; Célia Morais; Cínthia Baú Betim Cazarin; Daniel Tregidgo; Danilo Vicente Batista de Oliveira; Dirce Maria Lobo Marchioni; Eliana Bistriche Giuntini; Elias Jacob de Menezes Neto; Fillipe de Oliveira Pereira; Gabriela de Farias Moura; Hani R. El Bizri; Ingrid Wilza Leal (org.) Bezerra; Jailane de Souza Aquino; João Victor Mendes da Silva; Josiane Steluti; Juliana Kelly da Silva-Maia; Juliana Araujo Teixeira; Lara Juliane Guedes da Silva; Letícia Zenóbia de Oliveira Campos; Marcela Ãlvares Oliveira; Maria Elieidy Gomes de Oliveira; Mariana de Paula Drewinski; Marina Maintinguer Norde; Nelson Menolli; Priscila F. M. Lopes; Rafael Ricardo Vasconcelos da Silva; Rômulo Romeu Nóbrega Alves; Samara Camile Gomes da Silva; Sávio Marcelino Gomes; Severina Carla Vieira Cunha Lima; Thaís Q. Morcatty; Ulysses Paulino Albuquerque

Prioritization; Biodiversity; Consumption (sociology); Novel food; Global biodiversity; Food consumption; Public health; Food systems; Sustainability; Geography; Ecology; Environmental resource management; Biology; Healthy food; Traditional knowledge; Animal species; Key (lock)

2026-03-02https://doi.org/10.1038/s41598-026-39484-6Scientific Reports 20261hCG is not an alternative to eCG in the TAI protocol in Bos indicus cows, but it increases the efficiency of TAI protocols in cows that do not show estrusThe study evaluated the use of hCG at different times in the TAI protocol on the fertility of Bos indicus cows. In Experiment 1, cows received a progesterone device and 2 mg of estradiol benzoate (EB) on D0. The device was removed on D8.5 (study A) or D7 (study B), followed by 500 µg of cloprostenol and 1 mg of EB or estradiol cypionate. At this moment, cows were assigned to Control (no treatment), eCG (300 IU), or hCG (150 IU) groups. TAI occurred 36 h (A) or 48 h (B) post-device removal. In Experiment 2, in studies A and B, treatments [Control, GnRH (100 µg), or hCG (1000 IU)] were administered at TAI. In study C, cows received or did not receive 500, 800, or 1000 IU of hCG at TAI. In Experiment 1, cows of the control group had lower follicular growth (P < 0.01), and cows of the hCG group had greater estrus expression (P = 0.006) and early ovulation (P = 0.001). However, the cows of the hCG and control groups had lower P/AI (P = 0.01). In Experiment 2, cows of the hCG group had greater ovulation rates (P = 0.03) and pregnancy rates (P = 0.04). In study C, 1000 IU of hCG at TAI increased (tendency) the fertility (P = 0.07). In conclusion, hCG is not an effective alternative to eCG at device removal. However, 1000 IU of hCG at the time of insemination improves fertility in cows that did not express estrus.Matheus Pedroso Vicente; Laís Reis Carvalho; L.M.S. Simões; Lucas Araújo Lemos; Leonardo Teixeira; Kaio Batista dos Reis; Rodolfo Daniel Mingoti; H. Ayres; Laís Mendes Vieira; José Camisão de Souza; José Nélio de Sousa Sales

Ovulation; Follicular phase; Estradiol benzoate; Insemination; Artificial insemination; Cloprostenol; Fertility; Estrous cycle; Medicine; Pregnancy; Pregnancy rate; Equine chorionic gonadotropin; Andrology; Ovulation induction; Endocrinology; Luteal phase; Internal medicine; Animal science; Biology; Hormone

2026-03-02https://doi.org/10.1016/j.anireprosci.2026.108164Animal Reproduction Science 20261O Uso de Classificadores na Libras para a Construção de Conceitos sobre Ligações Químicas: um estudo semióticoTeaching Chemistry in a school that aims to be inclusive of deaf people involves the work of the Educational Translator/Interpreter, who needs to express complex and abstract concepts in Brazilian Sign Language - Libras that, sometimes, do not yet have a specific sign-term. At this context, there is a recurring use of classifiers to represent chemical phenomena and their subjects in Libras. Therefore, this article proposes to discuss, based on C. S. Peirce's semiotic theory, linguistic and semiotic aspects in the use of classifiers linked to the concept of 'chemical bond' and its relations with the production of meaning. The data were obtained in a Chemistry class with the theme 'Octet Rule', in the 1st year of High School, with the presence of a deaf student, in which, through filming that directed the focus on an Educational Portuguese Interpreter /Libras, it was possible to verify that the classifiers appeared as a productive resource with regard to the progressive construction of the concept of chemical bond and other terminologies that connect to such chemical phenomenon.Kevin Lopes Pereira; Marcelo Giordan; Ivoni Freitas-Reis

Semiotics; Interpreter; Theme (computing); Portuguese; Class (philosophy); Sign (mathematics); Linguistics; Psychology; Chemistry; Focus (optics); Resource (disambiguation); Sign language; Epistemology; Sociology; Cognitive science

2026-03-02https://doi.org/10.22600/1518-8795.ienci/2026v31n1p35Investigações em Ensino de Ciências 20261Entre pixels e percepções: a imagem dos cientistas geradas por IAEste estudo investiga como ferramentas de Inteligência Artificial (IA) generativa e representa visualmente cientistas e pesquisadores com ênfase na reprodução de estereótipos de gênero, raça e idade. A pesquisa analisou imagens criadas por ChatGPT, Microsoft Copilot e Bing Image Creator a partir dos termos “cientista” e “pesquisador”. A análise considerou critérios como gênero, cor da pele, idade, ambiente, vestimenta e elementos simbólicos. Os resultados mostraram que ChatGPT e Copilot reforçam estereótipos clássicos — como o cientista branco em jaleco — com variações de gênero conforme o termo utilizado. Já o Bing Image Creator apresentou maior diversidade, retratando cientistas em grupos colaborativos. O estudo contribui para o debate sobre os impactos socioculturais das tecnologias emergentes e propõe uma reflexão crítica sobre o uso educacional dessas ferramentas. Promover uma ciência mais inclusiva também exige revisar as imagens que alimentam o imaginário coletivo sobre quem pode ocupar esse lugar.Ingrid Nunes Derossi; André Vitor Carvalho

Image (mathematics); Pixel; Group (periodic table); Field (mathematics); Linguistics; Computer science; Philosophy; Epistemology; Mathematics; Humanities; Sociology; Mathematics education

2026-03-03https://doi.org/10.30905/rde.v10i1.1076DEVIR EDUCAÇÃO 20261Exploração mineira e o reassentamento em Cateme no distrito de Moatize - descaso ou prática de corrupção:Moçambique tem sido palco de um notável movimento de grandes empresas multinacionais em busca da exploração de recursos minerais, com destaque para a extração de carvão mineral na província de Tete, distrito de Moatize, a principal área de mineração do país. Neste artigo, propomos uma reflexão sobre as responsabilidades da empresa brasileira Vale, que conduziu um processo de reassentamento da população de Moatize em 2009 para a localidade de Cateme, a 40 km da vila sede de Moatize. Esse processo foi marcado por diversas reivindicações e insatisfações, tanto por parte dos atingidos quanto por organizações da sociedade civil moçambicana e estrangeiras, como a Human Rights Watch, que o consideraram repleto de falhas. Por meio de entrevistas e análise documental de relatórios de instituições da sociedade civil envolvidas no processo, adotamos uma perspectiva crítica em relação aos critérios de desapropriação de terras e às formas utilizadas para o reassentamento dos atingidos, além do não cumprimento das promessas feitas pela empresa. Isso resultou na violação dos direitos dos cidadãos, diante do silêncio das entidades governamentais, provocando impactos socioambientais que culminam em conflitos, pois tais impactos transcendem sua simplicidade, e suas consequências são vivenciadas atualmente. Uma pesquisa de campo, de natureza qualitativa e exploratória, foi realizada entre setembro de 2024 e fevereiro de 2025, período em que foram entrevistados, dentre os atingidos e técnicos dos serviços provinciais de infraestrutura que tutelam os serviços de recursos minerais, buscou-se entender os contornos e critérios utilizados no processo de reassentamento. Duas lições ou conclusões podem ser tiradas: um possível descaso da empresa Vale Moçambique sobre a precariedade a que foram submetidos os atingidos pelo reassentamento forçado e, por outro lado, o exacerbado nível de corrupção no governo de Moçambique, que permaneceu imune diante das atrocidades e violações aos direitos dos atingidos.Mário Miguel Fernando Ali; Bruno Milanez; Lúcia da Costa Ferreira

Process (computing); Work (physics); Theme (computing); Promotion (chess); Constitution; State (computer science); Subject (documents); Political science; Humanities; Philosophy; Balance (ability)

2026-01-26https://doi.org/10.12957/tamoios.2026.94418Revista Tamoios 20261Corporatização do território e minério-dependência:O objetivo deste artigo é analisar a formação da minério-dependência em Conceição do Mato Dentro (MG) a partir das evidências empíricas coletadas através de dados secundários. A investigação demonstrou que, apesar dos indicadores econômicos e sociais vultuosos, a implementação do Projeto Minas-Rio, sob responsabilidade da companhia Anglo American, não logrou superar os entraves ao desenvolvimento e, muito pelo contrário, está consolidando uma condição minério-dependente no município.Gustavo Iorio; Tádzio Peters Coelho

Context (archaeology); Subject (documents); Work (physics); Scope (computer science)

2026-01-26https://doi.org/10.12957/tamoios.2026.87204Revista Tamoios 20261SOCIETY 5.0 AND GYMNASTICS FOR ALL: A SYSTEMATIC REVIEWIn Society 5.0, the integration of technology with human life aims to put the human being at the center of all processes, ensuring that innovations respect and improve the true essence of the human experience. Gymnastics for All (GfA) is a practice recognized for its plurality, developed and practiced collectively, and flexible to group interests. This systematic review aims to identify how the aspirations of Society 5.0 are consistent with the precepts of GfA in the specialized literature. We conducted a search in Scielo, Scopus and Periódicos Capes databases. The search was conducted with the term "gymnastics for all", in English and Portuguese. 430 articles were identified, of which 28 were analyzed. The results are presented in five categories related to Society 5.0: Quality of Life; Soft Skills; Culture; Corporeality and Technology. We argue that GfA's potential aligns with the demands of Society 5.0, contributing to the promotion of a sport that values an active corporeality, essential for human development in contemporary times. The findings show that GfA can promote quality of life, aligning with Society 5.0's focus on human well-being, developing social skills and cooperation, essential for coexistence and personal development. Cultural appreciation at events and festivals promotes a critical and democratic understanding of popular culture. GfA promotes autonomy and self-esteem, important for personal and collective development and has demonstrated technological adaptability in times of crisis, integrating technology and human well-being. Therefore, GfA is aligned with the desires of Society 5.0 by centering the human being and promoting multifactorial quality of life.Claudia Correa; Juliana Andrade Vitral; Michele Viviene Carbinatto; Luísa Ávila da Costa Costa; Clara Mockdece Neves

Autonomy; Promotion (chess); Quality (philosophy); Adaptability; Human development (humanity); Democracy; Global citizenship; Product (mathematics); Sociology; Public relations; Engineering ethics; Scopus; Social change; Contemporary society

2026-02-28https://doi.org/10.52165/sgj.18.1.135-148Science of Gymnastics Journal 20261Conformidade das Retenções Previdenciárias Sobre Serviços em uma Empresa de Minas GeraisA presente pesquisa analisou a importância dos controles internos na mitigação de infrações fiscais, com ênfase na retenção e recolhimento de tributos incidentes sobre serviços tomados. O estudo abordou a relação entre a ausência de mecanismos de controle e a incidência de penalidades fiscais, bem como os impactos da implementação de melhorias estruturais no processo de conferência das obrigações tributárias. A metodologia adotada combinou revisão bibliográfica e estudo de caso, permitindo a análise detalhada do Auto de Infração ocorrido na empresa investigada. Os resultados demonstraram que a ausência de um sistema robusto de compliance fiscal foi determinante para o descumprimento das exigências tributárias, evidenciado pela falta de um fluxo organizado de conferência e pelo desconhecimento técnico dos responsáveis pela retenção de tributos. A implementação de controles internos eficazes reduz a exposição a autuações, melhora a eficiência operacional e fortalece a reputação corporativa, sendo um diferencial competitivo em um cenário regulatório complexo. Palavras-chave: Controles Internos. Compliance Tributário. Retenção de Tributos. ABSTRACT This research analyzed the importance of internal controls in mitigating tax infractions, with an emphasis on the withholding and collection of taxes levied on services received. The study addressed the relationship between the absence of control mechanisms and the incidence of tax penalties, as well as the impacts of implementing structural improvements in the process of verifying tax obligations. The methodology adopted combined a literature review and a case study, allowing for a detailed analysis of the Notice of Infraction issued to the investigated company. The results demonstrated that the absence of a robust tax compliance system was decisive for the non-compliance with tax requirements, evidenced by the lack of an organized verification flow and the lack of technical knowledge of those responsible for withholding taxes. The implementation of effective internal controls reduces exposure to audits, improves operational efficiency, and strengthens corporate reputation, representing a competitive advantage in a complex regulatory environment. Keywords: Internal Controls. Tax Compliance. Tax Withholding.Rodrigo Ferraz de Almeida; Lucas Fernando da Silva

Compliance (psychology); Tax evasion; Deductive method; Notice; Welfare economics; Humanities; Political science

2026-02-01https://doi.org/10.12819/2026.23.2.5Revista FSA 20261Protocolo para inserção de DIU de cobre na Atenção Primária à Saúde: ampliando e fortalecendo o acesso aos direitos sexuais e reprodutivos da mulherEste relato de experiência descreve a implantação de um protocolo para inserção do Dispositivo Intrauterino de Cobre por médicos da Atenção Primária à Saúde no município de Governador Valadares, visando ampliação do acesso aos direitos sexuais e reprodutivos das mulheres. O desenvolvimento da proposta baseou-se na construção colaborativa de um protocolo municipal e distribuição de insumos nas unidades básicas de saúde. A experiência foi exitosa, com apoio da gestão e adesão dos profissionais, contudo houve desafios como resistências culturais e estruturais. Os resultados demonstraram que a descentralização da inserção do DIU na APS contribuiu para ampliar o acesso e fortalecer a resolutividade e o vínculo com as mulheres do território, bem como favoreceu o planejamento familiar, fortalecendo as diretrizes das políticas nacionais de saúde da mulher. Conclui-se que a construção e execução do protocolo para inserção de Dispositivo Intrauterino na Atenção Primária à Saúde é exequível, replicável em outros municípios e contribui para a equidade em saúde, autonomia feminina e redução de gravidezes não planejadas, reforçando o papel estratégico da Atenção Primária à Saúde na garantia de direitos sexuais e reprodutivos.Guilherme Rhis; Lélia Cápua Nunes; Simone de Pinho Barbosa

Decentralization; Autonomy; Government (linguistics); Christian ministry; Political science; Humanities; Medicine; Gynecology

2026-03-03https://doi.org/10.18310/2446-4813.2026v12nsup3.4875Saúde em Redes 20261Avaliação da aprendizagem com o uso do ChatGPT: aprendizagens para a docência em químicaEste trabalho é resultado de uma pesquisa que teve como objetivo, investigar, na concepção dos licenciandos em Química, as contribuições e limitações do ChatGPT na elaboração de uma questão, para avaliar a aprendizagem de um conteúdo químico, abordado no Ensino Médio. A avaliação da aprendizagem é uma das atividades docentes e como pode ser elaborada com o auxílio da inteligência artificial generativa, é importante que os licenciandos reflitam sobre sua utilização. Para alcançarmos tal objetivo, elaboramos uma questão avaliativa, no âmbito da disciplina Avaliação do Processo de Ensino e Aprendizagem de Química, que está presente na matriz curricular das licenciaturas em Química de uma universidade federal, localizada em Minas Gerais, alinhando a temática avaliação junto ao uso da inteligência artificial generativa. A partir das respostas dos cinco licenciandos em Química, matriculados na disciplina, construímos os dados e os interpretamos pela Análise de Conteúdo. Verificamos que os licenciandos identificaram que o ChatGPT forneceu respostas que precisam ser revistas e corrigidas. Isso indica que os futuros professores não utilizarão as informações obtidas sem se certificarem que estão corretas, o que indica ser uma aprendizagem para a docência. Diante dos resultados obtidos, ressaltamos a importância da realização de outras pesquisas, pois ainda há uma lacuna na produção de conhecimento sobre a formação de professores em práticas avaliativas envolvendo inteligência artificial generativa.Andréia Francisco Afonso; Augusto Theodoro de Carvalho

Process (computing); Subject (documents); Data collection; Scope (computer science); Point (geometry); Perspective (graphical); Context (archaeology); Philosophy; Epistemology; Psychology; Humanities; Sociology

2026-03-03https://doi.org/10.30905/rde.v10i1.1173DEVIR EDUCAÇÃO 20261Prontuário Eletrônico do Cidadão como ferramenta para análise de demanda e planejamento das ações na Estratégia Saúde da FamíliaObjective: To develop a technical product based on the analysis of electronic health record data and population registry reports, using public health system care criteria, to enable planning of the weekly work schedule for doctors and nurses. The aim is to reorganize the professional agenda to better balance spontaneous and scheduled demand. Methods: A cross-sectional study conducted in primary care in a municipality in Minas Gerais, Brazil, with three Family Health units covering the entire population. Data from the Azul Family Health Strategy were analyzed. Variables such as age group, sex, shift, type of service, clinical conduct, and diagnosis were assessed using descriptive statistics. Based on the demand profile and care parameters, a standard weekly schedule was created to reorganize professionals’ agendas, incorporating both spontaneous and scheduled demand. Results: An imbalance was found between spontaneous and scheduled demand, with a predominance of unscheduled visits. The proposed solution reorganized the professionals’ weekly agenda, allocating time for scheduled care, health education, administrative activities, and planning, balancing care parameters with local needs. Conclusions: Reorganizing the work schedule can enhance care quality, increase service resolution, and strengthen primary care principles by valuing health promotion and allowing time for planning and administrative tasks, ultimately improving service organization and user access.Laís Andrade Nunes; Estela Márcia Saraiva Campos

Schedule; Work (physics); Primary care; Health care; Service (business); Population; Health services; Public health; Business; Operations management; Nursing; Product (mathematics); Primary health care; Promotion (chess); Family health; Health promotion; Medicine; Population health

2026-03-03https://doi.org/10.18310/2446-4813.2026v12nsup3.4942Saúde em Redes 20261Personalizing neuromodulation for chronic pain: A connectivity-guided randomized trialAbstract In this randomized, double-blind, controlled trial of 8 weeks of repetitive transcranial magnetic stimulation (rTMS) for chronic pain, we compared the classic primary motor cortex (M1) rTMS with a novel target-selection strategy based on pre-therapy cortical connectivity. Guided by principles of homeostatic plasticity, we tested whether stimulating the cortical site with the lowest pre-therapy global connectivity would be more effective than two active comparators: stimulating the site with the highest pre-therapy global connectivity or stimulating M1 independent of connectivity. Before starting rTMS treatment, TMS-evoked EEG potentials were recorded from four cortical targets: M1, the dorsolateral prefrontal cortex, the anterior cingulate cortex, and the posterosuperior insular cortex. For each target, global connectivity was quantified using a distance-weighted, phase-based index (debiased weighted phase lag index, wPLI) derived from pre- and post-TMS-evoked EEG activity, capturing both the magnitude and spatial extent of TMS-induced oscillatory phase locking across cortical regions. Target allocation in the Low- and High-Connectivity groups was based on this global connectivity measure. Ninety patients with chronic pain were randomized to Low-Connectivity, High-Connectivity, or Classic-M1 groups. Treatment consisted of 12 rTMS sessions delivered over 8 weeks to the assigned target. The primary outcome was the proportion of patients achieving ≥ 30% reduction in pain intensity. Secondary outcomes included continuous change in pain intensity, pain interference, sleep, fatigue, mood, quality of life, and patient global impression of change. No between-group differences were observed for primary or secondary outcomes (p > 0.05). In exploratory analyses, we examined whether pre-therapy local connectivity (within-target wPLI) predicted treatment response. In the Classic-M1 group, lower pre-therapy local M1 connectivity was associated with a greater reduction in pain intensity (r = 0.50, p = 0.005). This association was not observed in the Low- or High-Connectivity groups. A regression model including group-by-connectivity interaction indicated that the relationship between local connectivity and pain reduction differed between the Classic-M1 and High-Connectivity groups (p = 0.038). The results of this clinical trial showed that connectivity-based target allocation using global connectivity did not improve clinical outcomes. However, lower local M1 connectivity was associated with greater pain reduction following Classic-M1 stimulation, suggesting that local M1 connectivity may serve as a potential biomarker of response.Enrico De Martino; Margit M. Bach; Bruno Nascimento Couto; Anne Jakobsen; Pedro Nascimento Martins; Stian Ingemann-Molden; Adenauer G. Casali; Graven-Nielsen Thomas; Daniel Ciampi de Andrade

Transcranial magnetic stimulation; Neuromodulation; Primary motor cortex; Chronic pain; Anterior cingulate cortex; Dorsolateral prefrontal cortex; Randomized controlled trial; Functional magnetic resonance imaging; Electroencephalography; Medicine; Physical medicine and rehabilitation; Neuroscience; Stimulation; Quality of life (healthcare)

2026-03-04https://doi.org/10.64898/2026.03.02.26347430medRxiv 20261Acessibilidade em unidades residenciais da Instituição de Longa Permanência para Idosos Fundação Espírita João de FreitasO envelhecimento populacional impõe desafios urgentes à adequação do ambiente construído, especialmente nas Instituições de Longa Permanência para Idosos - ILPIs, onde o espaço físico desempenha papel determinante na autonomia e segurança dos residentes. Este trabalho tem como objetivo geral apresentar uma análise das condições de acessibilidade espacial em unidades residenciais da ILPI Fundação Espírita João de Freitas, localizada na cidade de Juiz de Fora, Minas Gerais, Brasil. A metodologia adotada foi composta pela técnica da documentação indireta – que proporcionou o embasamento teórico da pesquisa, por meio do estudo dos temas pessoa idosa, Instituição de Longa Permanência para Idosos, acessibilidade espacial e avaliação pós-ocupação - APO – e pela aplicação de um checklist – técnica de APO aqui elaborada com base na norma NBR 9050/2020 – principal referência normativa brasileira referente à acessibilidade – e na RDC n°502 da Agência Nacional de Vigilância Sanitária - Anvisa – resolução direcionada a moradias coletivas institucionais, no Brasil. O checklist foi aplicado nove unidades habitacionais (seis casas térreas e três apartamentos). Os resultados revelaram barreiras físicas críticas, destacando-se a inadequação da largura livre das portas em todas as tipologias, impedindo o fluxo autônomo de cadeirantes. Identificou-se uma disparidade funcional entre as tipologias: enquanto os apartamentos apresentam dimensionamento interno satisfatório nos sanitários e dormitórios, mas falham no acesso (esquadrias), as casas térreas apresentam limitações estruturais de área útil que inviabilizam manobras básicas. Observou-se ainda que na maior parte dos dormitórios, não há comandos de iluminação acessíveis na cabeceira da cama, o que pode comprometer a segurança no período noturno. Por fim, conclui-se que as unidades residenciais da instituição contempladas neste trabalho, demandam intervenções físicas para a promoção da acessibilidade, sendo os apartamentos a tipologia com maior potencial de adaptação imediata mediante o alargamento de vãos, enquanto as casas requerem reestruturações espaciais mais profundas.Yasmin Mello Clavilho de Souza; Daniela Chagas de Araújo Mariano; Samantha Campos Paiva Barrozo; Emmanuel Sá Resende Pedroso; Tatiana Tavares Rodriguez; Fabrício Rezende Fontenelle

Checklist; Population; Older people; Elderly people; Humanities; Medicine

2026-03-04https://doi.org/10.52641/cadcajv11i3.2148Cadernos Cajuína 20261Lippia agrestis (Verbenaceae): a new species from the northern Bahia state, Brazilian CaatingaBased on fieldwork and examination of Lantaneae herbarium collections, Lippia agrestis is here described as a new species. It is characterized by the unique combination of the following traits: leaves with margin entire near the base and conspicuously serrate towards the apex, spikes with peduncles 0.7‒1.5 cm long, basal bracts 0.5‒0.7 × 0.3‒0.4 cm, ovate, internal bracts 0.5‒0.6 × 0.2‒0.3 cm, lanceolate, corolla tubes 1‒1.2 cm long, well surpassing the bracts in length, externally densely pubescent-glandulous, densely sericeous ovary, and drupaceous fruits with a strigose dorsal surface. The species is found in the Raso da Catarina Ecoregion, within the Caatinga domain (Bahia state, Brazil). It grows in sandy, bushy caatinga, at elevations between 405 and 430 m. Illustrations, a distribution map, and comparisons with similar species (Lippia carrascoana, Lantana restingensis, Lippia maximilianii) are provided. A preliminary conservation status assessment suggests that Lippia agrestis qualifies as Endangered (EN).MARIA TÂNIA CORREIA LIMA; Fátima Regina Gonçalves Salimena; Pedro Henrique Cardoso; ADILVA DE SOUZA CONCEIÇÃO

Lippia; Bract; Herbarium; Verbenaceae; Conservation status; Endangered species; Biology; Botany; IUCN Red List; Taxonomy (biology); Lantana; Zoology

2026-03-05https://doi.org/10.11646/phytotaxa.744.2.4Phytotaxa 20261TECHNIQUE, IMAGINARY AND SAMBA – THE INFLUENCE OF ARTIFICIAL INTELLIGENCE IN BRAZILIAN CARNIVAL, 2025This work seeks to survey the ways in which artificial intelligence has affected Brazilian carnival, especially that of samba schools in Rio de Janeiro and São Paulo and its cultural environment. This survey will serve as the basis for a cultural critique that will reflect on the ways in which this imaginary of technique, which imputes to us an almost Faustian urgency of efficiency, productivity, speed and future, affects a cultural manifestation marked by social criticism, revolution and appreciation of community and artisanal work.The basis for this criticism is the theory of archetypological imagery, which is that this epitome of technique is a demarcation of Western ways of feeling, thinking and acting since the 19th century (Durand, 2012). The reasoning is complemented by questions from Neil Postman, for whom the relentless advancement of technology harms the preservation of traditions, impacting mental processes and social relations in a community (1994, p. 12). Far from seeking an apocalyptic alignment that rejects technological transformations, we understand that popular festivals are characterized by social dynamism. However, by questioning the way in which these adherences have been made in an unreflective way, we hope to collaborate with critical thinking and complex reflection on a phenomenon that will affect our own way of relating to tradition.Andriolli Costa; Thales Martins

The Imaginary; Criticism; Epitome; Phenomenon; Cultural heritage; Ethnography; Sociology; Epistemology; Aesthetics

2026-01-02https://doi.org/10.5210/spir.v2024i0.15102AoIR Selected Papers of Internet Research 20261Do Gramado ao ConsoleAnalisou-se o futebol virtual como prática de lazer entre jovens brasileiros, investigando como ressignifica estruturas socioculturais do futebol tradicional. A partir de 250 comentários de uma transmissão da final da Copa do Mundo de EA SPORTS FC 2024 no YouTube, identificaram-se seis eixos: críticas ao jogo; rivalidade e competitividade; discurso de ódio e xenofobia; identidade e clubismo; redes de sociabilidade; e excitação emocional. Os resultados revelam que o futebol virtual não só reproduz, mas transforma dinâmicas tradicionais, mantendo rivalidades mediadas por algoritmos. O anonimato potencializou discursos de ódio e reações emocionais exacerbadas. Conclui-se pela urgência de uma Educação para e pelo Lazer Virtual.Rubian Diego Andrade; Rafael José Gonçalves de Assis; Gisele Maria Schwartz

Subject (documents); Work (physics); Virtual reality; Natural (archaeology); Humanities; Sociology; Computer science

2026-03-01https://doaj.org/article/1b04b45c952b445894d0c6352097b800DOAJ (DOAJ: Directory of Open Access Journals) 20261Mechanical performance of cementitious composites containing nanofibrillated cellulose and steel slagRodrigo Felipe Santos; José Carlos Lopes Ribeiro; José Maria Franco de Carvalho; Washington Luiz Esteves Magalhães; Leonardo Gonçalves Pedroti; Gustavo Henrique Nalon; Gustavo Emílio Soares De Lima

Cellulose; Slag (welding); Cementitious; Composite number; Nanofiber; Materials science; Composite material

2026-03-05https://doi.org/10.1016/j.conbuildmat.2026.145686Construction and Building Materials 20261Does the environmental degradation gradient affect the macroinvertebrate community in springs?Anthropogenic alterations in natural environments can lead to changes in benthic communities, producing profound impacts on ecological processes in spring ecosystems. In this study, the objective was to investigate the effect of different land uses (urban, pasture, eucalyptus, and native forest) on the taxonomic structure and functional feeding groups (FFGs) of benthic macroinvertebrates in springs. The study was conducted in 40 springs located in the Ipanema stream sub-basin, in the municipality of Ipatinga, Minas Gerais, Brazil. All statistical analyses were performed in R software, version 4.5.0. In springs located in native forest, eucalyptus, and pasture areas, the families Chironomidae, Calamoceratidae, and Ceratopogonidae were the most frequent. In contrast, urban areas presented the lowest number of individuals, with Chironomidae, Oligochaeta, and Ceratopogonidae being the most abundant taxa. Vegetation cover percentage varied significantly among land uses, influencing richness and abundance. Richness (114.64; p < 0.005) and abundance (43.646; p < 0.005) were distinct among the evaluated land uses. Our results showed that the taxonomic structure of macroinvertebrate communities responded to the environmental degradation gradient caused by anthropogenic activities, especially urbanization. We verified that the abundance of functional feeding groups was distinct among the land uses, being higher in all categories analyzed in areas of native forest.Alice Arantes Carneiro; Luiza Pedrosa Guimarães; Alessandra Angélica de Pádua Bueno

Affect (linguistics); Degradation (telecommunications); Environmental degradation; Invertebrate; Community; Aquatic environment; Environmental science; Ecology

2026-03-05https://doi.org/10.1080/01650521.2026.2631576Studies on Neotropical Fauna and Environment 20261Inflation targeting and economic performance: an empirical analysisGlobal financial disturbances challenge countries’ ability to maintain stable economic performance, raising questions about the effectiveness of monetary policy frameworks. This study evaluates how inflation-targeting (IT) countries respond to external spillovers compared to non-IT economies. Using entropy balancing combined with a differences-in-differences strategy for 1980–2019, we address self-selection and estimate causal effects on real per capita income, debt-to-GDP, and employment. The results indicate that IT adoption may involve higher employment costs under shifting global conditions, while effects on output and public debt vary across income groups. Overall, the findings suggest that IT economies display heightened vulnerability to external spillovers.Eliene de Sá Farias; Leonardo Bornacki de Mattos; Luciano Ferreira Gabriel

Inflation targeting; Inflation (cosmology); Empirical evidence; Real interest rate; Monetary policy; Economics; Monetary economics; Keynesian economics; Macroeconomics; Econometrics

2026-03-04https://doi.org/10.1080/17520843.2026.2634510Macroeconomics and Finance in Emerging Market Economies 20261Complete genome sequence of the phage UNICOR_HM-QL, a Berlinviru s infecting Escherichia coli and Salmonella with potential for biocontrol in milk for Costeño cheese productionABSTRACT We report the genome sequence of phage UNICOR_HM-QL, isolated from Costeño cheese, a Colombian artisanal fresh cheese produced with raw milk. This lytic phage infects Escherichia coli (ATCC 11229) and Salmonella enterica serovar Enteritidis (ATCC 13076). Comparative genomic analyses assigned UNICOR_HM-QL to the genus Berlinvirus . The genome comprises 39,561 bp with a GC content of 48.9% and encodes 47 coding DNA sequences (CDSs), with no tRNA genes detected.Fernando A Mendoza-Corvis; Pedro Marcus Pereira Vidigal; Humberto Moreira Húngaro; Omar Perez Sierra; Ana Maria Hernández Arteaga; Maryoris E. Soto Lopez

Lytic cycle; Genome; Whole genome sequencing; Gene; Bacteriophage; Raw milk; GC-content; Nucleic acid sequence; DNA sequencing; Biology; Genetics; Microbiology; DNA; Transfer RNA; Virology; Comparative genomics; Genome project

2026-03-05https://doi.org/10.1128/mra.00154-26Microbiology Resource Announcements 20261Ultra-processed foods in research and policyLilian dos Santos Rahal; Patrícia Chaves Gentil; Gisele Ane Bortolini; Felipe Silva Neves; Bruna Pitasi Arguelhes

Blueprint; Complement (music); Raising (metalworking); Key (lock); Business; Political science

2026-03-01https://doi.org/10.1016/s0140-6736(26)00109-1The Lancet 20261Psychometric properties of shortened versions of the Eating Disorder Examination-Questionnaire in Brazilian womenOBJECTIVE: The Eating Disorder Examination-Questionnaire (EDE-Q) is a widely used 28-item instrument for screening eating disorders, of which 22 are attitudinal items used to compute subscale scores and to assess factorial structure, while six open-ended items assess behavioral frequency and are excluded from dimensional analyses. Shorter versions, such as the EDE-Q7, EDE-Q8, and EDE-Q18, have been proposed to enhance accessibility and psychometric properties. This study aimed to evaluate different factorial structures of the EDE-Q and identify the model that best fits a sample of Brazilian adult women. METHODS: A total of 712 women completed the EDE-Q and measures of body satisfaction and sociocultural pressures. The factorial structure was analyzed through confirmatory factor analysis (CFA), and convergent validity and internal consistency were also assessed. RESULTS: The multifactorial structure of the original EDE-Q and the 18-item model did not fit the sample well. Although the 7-item model showed acceptable fit, the 8-item version demonstrated the best fit. The EDE-Q8 factors showed a negative association with appearance evaluation and body area satisfaction, and a positive association with internalization of the thin and muscular body ideal and body mass index. Internal consistency was adequate. CONCLUSION: The 8-item short version of the EDE-Q is a reliable and practical psychometric tool for assessing disordered eating behaviors in Brazilian adult women. Future studies should explore the psychometric performance of the EDE-Q8 across different age ranges, gender groups, and clinical populations to strengthen evidence for its cross-cultural validity and generalizability. LEVEL OF EVIDENCE: Level III, well-designed cohort or case-control analytic studies.Andreia Dutra Gonçalves; Vitoria Bagolin; Pedro Henrique Berbert de Carvalho; Maria Fernanda Laus

Cohort; Psychometrics; Cohort study; Quality of life (healthcare); Psychology; Clinical psychology; Psychiatry

2026-03-06https://doi.org/10.1007/s40519-026-01835-7Eating and Weight Disorders - Studies on Anorexia Bulimia and Obesity 20261The Effect of L-Tryptophan Intake on Dynamic Strength in Paralympic PowerliftingIntroduction: L-tryptophan supplementation has been studied in endurance sports with controversial results, and its influence on maximal strength sports remains largely unexplored. This study investigated whether L-tryptophan supplementation improves dynamic strength indicators in Paralympic powerlifting athletes. Methodology: A randomized, double-blind, crossover clinical trial was conducted with 13 paralympic powerlifting athletes. The athletes were supplemented with L-tryptophan or placebo for 72 hours before training. Strength was assessed using an encoder, measuring mean propulsive velocity (MPV), maximal velocity ( V max ), and power (PO) at different time points (pre, post, 24, and 48 hours) and loads (45% and 80% of 1 RM). Results: L-tryptophan supplementation resulted in higher MPV, V max , and PO values at the pre-exercise time point compared to placebo. However, after exercise, this difference diminished, and the benefits of supplementation were not sustained after 48 hours. Conclusion: L-tryptophan supplementation appears to temporarily improve pre-exercise strength performance in Paralympic powerlifting athletes, possibly by influencing neuromuscular relaxation.Márcio Getirana-Mota; Felipe J. Aidar; Raphael Fabrício de Souza; Ciro José Brito; Taísa Pereira Santos; J. Barbosa Lacerda; LUCIO MARQUES VIEIRA-SOUZA; Georgian Badicu

Body weight; Breaking strength; Strength training; Physical strength; Mathematics; Animal science

2026-03-01https://doi.org/10.1177/11786469261420614International Journal of Tryptophan Research 20261profmsouza/artigo-ress-tempo-espera-prostata: Dados e Código: Tempo de Espera para Tratamento de Neoplasia de Próstata (RESS)Este release contém os dados secundários anonimizados e o script computacional em R referentes ao artigo original: "Tempo para início do tratamento oncológico de neoplasia de próstata no Sistema Único de Saúde: estudo transversal, Minas Gerais, 2014-2019" Autores: Keila Cristina Machado Quintão Vila Real, Leonardo Oliveira Leão e Silva, Márcio Luís Moreira de Souza, Bernardo Gomes Barbosa Nogueira, Suely Maria Rodrigues. Arquivos incluídos nesta versão (v1.0.0): dados_saude_do_homem.csv: Banco de dados anonimizado proveniente dos Registros Hospitalares de Câncer (RHC). script_analise_ress.R: Script comentado contendo todas as etapas de limpeza de dados, estatística descritiva e modelagem inferencial (Regressão Logística). README.md: Documentação do projeto para Ciência Aberta.Márcio Souza

Historical record; Statistical analysis; Domain (mathematical analysis)

2026-03-06https://github.com/profmsouza/artigo-ress-tempo-espera-prostata/tree/v1.0.0Open MIND 20261Multi-Memory Approach for Random Number Generators in FPGARandom number generation is essential in many application domains, including high-energy physics simulations. Implementing Monte Carlo methods that generate samples following a desired probability distribution is particularly challenging on hardware platforms such as FPGAs. Direct implementations of analytical distribution functions are often resource-intensive, making them impractical for real-time systems. An efficient alternative is the use of the inverse cumulative distribution function (CDF), which can be implemented using look-up tables (LUTs). In this approach, a uniformly distributed random number—generated by Linear Feedback Shift Registers (LFSRs)—is used as an address to access LUTs containing discretized x-axis values of the CDF, thereby yielding the target random variable. However, this method presents limited accuracy in low-probability regions of the distribution. To address this issue, this paper proposes a segmented CDF implementation based on multiple LUTs, improving resolution in poorly sampled regions. A cascade of decision logic selects the appropriate memory output, increasing resolution only where necessary while optimizing memory usage. The proposed method was validated through Monte Carlo simulations in particle physics applications, achieving close agreement with theoretical distributions while requiring limited FPGA resources and no DSP blocks.Thiago Campos Acácio Paschoalin; Tiago Motta Quirino; Luciano Manhães de Andrade Filho

Random number generation; Monte Carlo method; Field-programmable gate array; Convolution random number generator; Cumulative distribution function; Cascade; Digital signal processing; Computer science; Algorithm; Computer engineering; Particle filter; Function (biology); Probability distribution; Computational science; Inverse; Implementation; Random access

2026-03-06https://doi.org/10.3390/app16052537Applied Sciences 20261profmsouza/artigo-ress-tempo-espera-prostata: Dados e Código: Tempo de Espera para Tratamento de Neoplasia de Próstata (RESS)Este release contém os dados secundários anonimizados e o script computacional em R referentes ao artigo original: "Tempo para início do tratamento oncológico de neoplasia de próstata no Sistema Único de Saúde: estudo transversal, Minas Gerais, 2014-2019" Autores: Keila Cristina Machado Quintão Vila Real, Leonardo Oliveira Leão e Silva, Márcio Luís Moreira de Souza, Bernardo Gomes Barbosa Nogueira, Suely Maria Rodrigues. Arquivos incluídos nesta versão (v1.0.0): dados_saude_do_homem.csv: Banco de dados anonimizado proveniente dos Registros Hospitalares de Câncer (RHC). script_analise_ress.R: Script comentado contendo todas as etapas de limpeza de dados, estatística descritiva e modelagem inferencial (Regressão Logística). README.md: Documentação do projeto para Ciência Aberta.Márcio Souza

Historical record; Statistical analysis; Domain (mathematical analysis)

2026-03-06https://doi.org/10.5281/zenodo.18890406Zenodo (CERN European Organization for Nuclear Research) 20261O projeto poético de Rupi Kaur: a presença de topoi e o entrelace retórico com a produção de autoria femininaO presente artigo se dedica a investigar o projeto poético da escritora indo-canadense Rupi Kaur em suas três obras publicadas em língua portuguesa, sendo elas Outros jeitos de usar a boca (2017), O que o sol faz com as flores (2018) e Meu corpo minha casa (2020). Tem-se como objetivo compreender de que modo a repetição de topoi, com base nas colocações de Kaur (2018) e Achcar (1994), exerce uma função retórica nessa produção que apresenta um forte teor coletivo e de subversão na atualidade. Além disso, mostra-se também imprescindível apresentar aspectos desse entorno social, a citar o silenciamento e as violências historicamente cultivadas em sociedades basilarmente patriarcais, a fim de melhor estabelecer a relação entre a poesia de Kaur e o movimento feminista para, então, alcançar a conexão com outras escritoras mulheres através dos lugares-comuns. Para tanto, são levadas em consideração análises realizadas por teóricos como Foucault (1997) e Barthes (2004), no ensejo de trazer à tona o recurso da posição-autor e da pluralidade da tessitura textual, para além de compreensões sobre memórias culturais que são criadas a partir de uma escrita com topoi, consoante aos apontamentos de Andrade (2020). Nessa perspectiva, mesmo que de modo ainda preliminar, pretende-se demostrar como são criadas redes de conexão que, em uma visão sistêmica, contribuem para o movimento feminista, as suas pautas e a modificação de padrões hegemônicos.Fernanda Barroso e Silva; Nícea Helena de Almeida Nogueira

Context (archaeology); Domain (mathematical analysis); Modernity; Humanities; Art; Philosophy

2026-03-05https://doi.org/10.4025/actascilangcult.v48i1.73539Acta Scientiarum Language and Culture 20261Artaud e os Tarahumaras: uma releitura mitopoéticaObserva-se que a obra de Antonin Artaud possui um lugar relevante no pensamento contemporâneo, pois sua marcante expressão possibilita diálogos interdisciplinares. As peculiaridades de sua obra apontam para diferentes formas de análise e interpretação. Um dos desafios enfrentados para a compreensão de sua obra decorre do fato de que Artaud não costumava fundamentar suas ideias de modo estritamente linear, objetivo e racional. Nesse sentido, emergem na literatura especializada questionamentos sobre a validade das narrativas desse artista. Diante desse cenário, o presente estudo propõe uma análise que leva em consideração algumas singularidades, sobretudo enfatizando o lugar da faculdade imaginativa na obra artaudiana. Para esta pesquisa, foram selecionados os escritos relacionados à viagem ao México e à experiência entre os povos tarahumaras. Este estudo embasou-se na teoria da psicologia analítica, considerando os dois tipos de pensamento delineados por Carl Gustav Jung: o pensamento dirigido ou linguístico e o mitológico ou de fantasia. Além disso, foram analisados os conteúdos projetivos e compensatórios que emergem das fantasias de Artaud na relação que estabeleceu com os tarahumaras e a importância do mito solar que permeia esse encontro.Hortênsia Isabela Santos Vieira; Walter Melo

Relation (database); Period (music); Domain (mathematical analysis); Structural approach; Philosophy; Humanities

2026-03-06https://doi.org/10.21901/2448-3060/self-2026.vol-11.240Self - Revista do Instituto Junguiano de São Paulo 20261“Petrópolis vai ‘agachar-se’”: a passagem de Alfred Agache por Petrópolis (RJ) durante o Estado Novo no Brasil (1937-1945)O presente artigo pretende elucidar a pouco estudada passagem do urbanista Alfred Agache pelo interior fluminense no início da década de 1940, com especial destaque para seus trabalhos em Petrópolis (RJ). Além disso, espera-se propiciar a compreensão de como o tema Turismo aparece nas proposições de Agache no período. Para tanto, examinaram-se os discursos proferidos pelo urbanista francês sobre o tema com base nas proposições que ele e sua equipe, formada também por outros urbanistas, como Abelardo Coimbra Bueno, elaboraram para a urbanização da cidade mencionada. Tal levantamento foi realizado por meio de pesquisa documental em fontes produzidas no período delimitado (1937-1945). Por fim, realizou-se uma análise das ideias propostas pelos urbanistas, confrontando-as com as intervenções que se concretizaram anos depois, em que sobressai a atividade turística como determinante na cidade nos anos posteriores.André Barcelos Damasceno Daibert

Context (archaeology); Situated; Order (exchange); Tourism; State (computer science); Humanities; Geography

2026-03-06https://doi.org/10.22296/2317-1529.rbeur.202606ptRevista Brasileira de Estudos Urbanos e Regionais 20261Influence of Mood States on Sensory Perceptions Toward Passion Fruit Juice With Different Sugar ContentABSTRACT High sugar intake and exposure to negative mood states are known to influence food‐related decisions; however, the specific effects of short‐term mental fatigue on sensory perception and label evaluation remain unclear. This study investigated the impact of experimentally induced mental fatigue on hedonic responses, ideal sweetness perception, and front‐of‐package label evaluation of passion fruit juice with different sugar contents. One hundred healthy adults (18–60 years) participated in a randomized crossover design, evaluating juice samples (0%, 5%, 10%, 15%, and 20% sucrose) and three label formats under control and Stroop test–induced mental fatigue condition (SMF). Mood alterations were confirmed using the Profile of Mood States (POMS), showing increased tension ( p = 0.013) and confusion ( p = 0.054) and reduced vigor ( p = 0.030) under SMF, leading to a moderate overall mood disturbance ( d = 0.320). Despite the mood changes caused by the SMF, hedonic tests revealed no significant differences between fatigue and control conditions for overall acceptance or ideal sweetness perception; in both conditions, the 10% sucrose sample was rated closest to the ideal and showed the highest acceptance. Similarly, purchase intention did not differ between groups for any label. However, within‐group comparisons indicated that labels without a high‐sugar warning elicited higher purchase intention than those displaying a warning seal, regardless of fatigue state. Analysis of open‐ended responses demonstrated that SMF reduced attention to peripheral visual elements, such as design and brand identification, while attention to critical nutritional information (e.g., sugar content and nutrition facts) remained unchanged. These findings suggest that SMF alters mood but does not significantly impair hedonic judgments or sweetness perception, while selectively narrowing attentional focus during label evaluation.Laura Falavinha Vieira Bresciani; Sabrina Carvalho Bastos; Taynara de Oliveira Ferreira; Filipe Ribeiro; Rhaí André Arriel e Oliveira; Katiúcia Alves Amorim; Jéssica Ferreira Rodrigues

Sweetness; Mood; Profile of mood states; Perception; Taste; Passion fruit; Crossover study; Sugar; Stroop effect; Psychology; Food science; Craving; Clinical psychology; Affect (linguistics); Confusion; Audiology; Arousal; Sensory system; Developmental psychology

2026-02-01https://doi.org/10.1111/joss.70114Journal of Sensory Studies 20261Understanding the solid-state reaction of layered zinc hydroxide nitrate with citric acid: An experimental–computational investigationCamila K.S. Azevedo; Sérgio R. Tavares; Alexandre A. Leitão

Citric acid; Thermogravimetric analysis; Hydroxide; Zinc; Zinc nitrate; Zinc hydroxide; Salt (chemistry); Thermal analysis; Chemistry; Inorganic chemistry; Elemental analysis; Reaction mechanism; Metal hydroxide; Chemical reaction; Characterization (materials science); Lithium hydroxide; Sodium hydroxide; Infrared spectroscopy

2026-03-07https://doi.org/10.1016/j.jssc.2026.125940Journal of Solid State Chemistry 20261Reconstruction of the Historical Ecologically Suitable Areas of Brasiliscincus (Squamata, Scincomorpha, Scincidae): A Review of Records and Insights Into Its Distribution PatternsABSTRACT Ecological niche modelling (ENM) is a valuable tool in climate studies, supporting investigations into species distributions and historical refugia. This approach is especially relevant for lizards in the genus Brasiliscincus whose poorly defined distributional limits underscore the need for ENM‐based studies to better understand their biogeographic patterns. After an extensive record review, we applied ENM to analyse the distribution patterns of Brasiliscincus spp. and assess whether bioclimatic factors predict niche similarity and equivalence between B. agilis and B. heathi . Using Ensemble of Small Models, we mapped habitat suitability for current and historical periods. Additionally, we tested niche equivalence and similarity and assessed niche overlap to quantify shared ecological space between both species. Occurrence records and the potential distribution indicate that B. heathi is distributed across open areas of the Caatinga and Cerrado, whereas B. agilis occurs in the coastal regions of the Atlantic Forest, from Bahia to Rio de Janeiro, including its first record in the state of Minas Gerais. Brasiliscincus caissara , in turn, appears to be restricted to the Restinga ecosystem in the state of São Paulo. No evidence of sympatry was found among these species. Despite their close geographic occurrence, the potential distributions overlapped only minimally and showed low climatic niche overlap, indicating that they occupy distinct niches that are neither equivalent nor more similar than expected by chance. The distribution boundaries between species appear to be shaped by both current and historical climatic suitability, as well as geographical barriers. The boundary between B. agilis and B. heathi coincides with the mouth of the Paraguaçu River and Todos os Santos Bay and B. agilis is separated from B. caissara by only 80 km, with the Serra da Bocaina and Ilha Grande Bay acting as a natural barrier. Our results are supported by models with good performance, consistent with the actual occurrences of B. agilis and B. heathi , in agreement with their evolutionary history, stable climatic areas and Pleistocene refugia.M. S. Neves; Hugo Andrade; Emanuel T. Silva; Thayssa A. Santos; Karoline Ceron; Sofia Velasquez; Henrique C. Costa

Niche; Ecological niche; Environmental niche modelling; Sympatry; Ecosystem; Habitat; Species distribution; Distribution (mathematics); Ecology; Geography; Biogeography; Niche segregation; Climate change; Macroecology; Similarity (geometry)

2026-02-24https://doi.org/10.1111/aec.70186Austral Ecology 20261Thermo-mechanical modelling and experimental production of aluminium circular form detail using three-level hierarchical WAAM modelWire arc additive manufacturing (WAAM) offers significant potential for large-scale metal component production but remains limited by problems such as heat accumulation, residual stresses, and incomplete process automation. This study focuses on the development and validation of a three-level hierarchical WAAM model-bead, layer, and wall-to enable predictive thermo-mechanical simulation and informed experimental fabrication of an aluminium circular form detail. Each hierarchical level is modelled through transient coupled thermal-structural finite element analysis in ABAQUS, incorporating experimentally derived aluminium 6061 material data, heat input implementation through DFLUX, and convection radiation boundary conditions. The methodology includes sequential deposition modelling with 320 beads, thermal monitoring at critical nodes, and structural evaluation of residual stresses. Simulation results show that bead-level heat distribution and residual stresses remain within safe limits, layer-level deposition produces stable thermal oscillations without excessive heat accumulation. While wall-level revealing progressive heat buildup leading to remelting of previously deposited layers. A mitigation strategy is introduced by implementing layer-wise cooling to [Formula: see text]C, which successfully suppresses cumulative thermal loading and restores structural stability. The validated simulations guided an experimental conduction with a robotic GMAW-CMT system, infrared monitoring, and identical process parameters. The manufactured detail closely matches the target geometry, demonstrating the applicability of a three-level hierarchical thermo-mechanical framework for guiding WAAM process planning. This work demonstrates the original contribution of a practical, simulation to experiment workflow based on a three-level hierarchical WAAM model, capable of predicting thermal issues before manufacturing process, informing temperature control strategies and supporting the possibility of the generation of an automated program software for the robot control during the additive manufacturing process.Pavlo Anikin; Flávia Bastos; Galina Shilo

Thermal conduction; Residual; Thermal; Process (computing); Aluminium; Deposition (geology); Finite element method; Workflow; Work (physics); Transient (computer programming); Computer science; Mechanical engineering; Materials science; Residual stress; Fabrication; Heat generation; Domain (mathematical analysis); Production (economics); Material properties; Heat exchanger; Boundary (topology)

2026-03-08https://doi.org/10.1038/s41598-026-42149-zScientific Reports 20261Neurotourism Beyond Promotion: A Neuroaesthetic Analysis of Mediated Landscapes in the TV Series Killing EveTourism is increasingly shaped by visual experiences of place mediated through television series and audiovisual fiction. Although film-induced tourism research has widely examined how media representations influence destination image and tourist responses, limited attention has been given to the perceptual and cognitive processes through which mediated landscapes are visually attended to and mentally organised, particularly from a neuroaesthetic perspective focused on early perceptual and attentional mechanisms in fictional contexts where tourism is not explicit. Addressing this gap, this study adopts a process-oriented neuroaesthetic approach to examine how landscapes in the television series Killing Eve are visually attended to and cognitively processed as destination imagery. An exploratory mixed-methods design combined qualitative content analysis of free recall responses (n = 260) with simulated visual attention modelling based on low-level visual features. The findings reveal a two-stage process of mediated landscape experience: visual attention initially guided by perceptual salience, followed by the selective cognitive stabilisation of certain elements as destination imagery through recall, imagination and narrative association. The study demonstrates that mediated landscapes are not processed as holistic destination images, but as selectively organised and emotionally inflected elements emerging from the interaction between visual attention and imagery processes.Lucília Cardoso; Isabela Novaes-Silva; Guilherme Augusto Pereira Malta; Humberto Fois-Braga; Patrick Moratori; Carla Fraga

Perception; Narrative; Mental image; Tourism; Recall; Perspective (graphical); Cognition; Television series; Cognitive psychology; Psychology; Visual perception; Exploratory research; Eye movement; Cognitive map; Cognitive science; Qualitative analysis; Visual attention; Process (computing)

2026-03-09https://doi.org/10.3390/tourhosp7030078Tourism and Hospitality 20261Inteligência artificial e orientalismo: a propagação do discurso Pró-Israel através de imagens por Carla Zambelli no instagramThis study examines how artificial intelligence-generated images of Palestinians and Israelis circulate on Instagram and shape the Brazilian social imaginary about the conflict. It focuses on posts from the profile of Congresswoman Carla Zambelli, a prominent pro-Israel voice in Brazil. The corpus consists of AI-generated images published between October 7, 2023, and February 23, 2024, addressing the attacks in the Gaza Strip involving Hamas and Israel. The materials were analyzed using Content Analysis (BardinJoão Paulo Malerba; A. G. B. Almeida

The Imaginary; Social media; Photography; Field (mathematics); Artificial intelligence; Art

2026-03-02https://doi.org/10.11606/issn.2176-1507.v33i1p165-192Revista Alterjor 20261Fruit and seed attributes of plants derived from crossing between triploid Passionflower cytotypesTriploid plants are usually sterile or produce non-viable seeds, but may produce fruits. This study examined the morphological and reproductive characteristics of triploid Passiflora cincinnata Masters, with a focus on fruit and seed production. Triploid plants were obtained through in vitro cultivation of the endosperm via somatic embryogenesis, whereas diploid plants were raised through seed germination. Diploid and triploid plants were confirmed by flow cytometry and cytogenetic analyses. Cross-pollination and self-pollination yielded, on average, 18 fruits per plant in the cytotype diploid, while triploids produced only 6 fruits. Diploid plants have more uniform fruits, while triploid plants showed variations in size. Seeds with malformations or absence of zygotic embryos and endosperm were observed in triploid cytotypes, while remaining below 1.5% in diploid cytotypes. It was observed that the highest germination rate of 80% occurred in seeds of the diploid cytotype, compared to 53.3% in triploids. The seedlings from the cross between diploid plants contained 3.29 pg of nuclear DNA and a chromosome number of 2n = 2x = 18, while the seedlings from the cross between triploid plants had progeny with 3.37 pg of nuclear DNA and variable chromosomes numbers, of 2n = 19 (2n + 1), 2n = 15 (2n - 3), and 2n = 16 (2n - 2) chromosomes confirming aneuploidy in the progeny. Stomatal analysis showed that diploid plants displayed the highest stomatal density, whereas triploid and aneuploid plants had the greatest length and width of stomata. The density and width of pavement epidermal cells varied among cytotypes. Meiotic disturbances in triploid plants cause phenotypic alterations in the progeny, resulting in delayed vegetative development, low vigor, non-uniform germination, and death during the juvenile phase. The genetic material of aneuploids is a resource for gene mapping, enabling the modification or production of new cultivars with economically relevant phenotypes.Claudinei da Silva Souza; Marcelo Dias Machado; Alana Jeniffer Alves dos Santos; Gabrielle Balbo Crepaldi; Elyabe Monteiro de Matos; Lyderson Fácio Viccini; Ílio Fealho de Carvalho; Wagner Campos Otoni; Aryane Campos Reis; Diego Ismael Rocha; Maurecilne Lemes da Silva

Ploidy; Endosperm; Meiosis; Germination; Chromosome; Polyploid; Aneuploidy; Zygote; Biology; Botany; Nuclear DNA; Chromosome number; Plant physiology; Embryo; Cytogenetics

2026-03-09https://doi.org/10.1007/s10265-026-01695-3Journal of Plant Research 20261Níveis de atividade física, capacidade funcional e sua associação com a função cognitiva em pacientes em hemodiálise: um estudo TransversalIntroduo: A Hemodilise a terapia renal substitutiva mais comum nos estgios finais da doena renal crnica (DRC).Este tratamento impe uma rotina exigente, mudanas no estilo de vida e at comportamento sedentrio.Nveis baixos de atividade fsica em pacientes em hemodilise esto associados a desfechos clnicos adversos.Objetivo: Investigar o nvel de atividade fsica, o desempenho fsico e sua associao com a funo cognitiva de pacientes em hemodilise.Mtodos: Anlise transversal e secundria, do centro de Porto Alegre includo no estudo multicntrico SARC-HD, que incluiu apenas o centro de Porto Alegre, uma das 19 unidades de dilise em todo o Brasil.Os participantes foram avaliados quanto ao nvel de atividade fsica (Questionrio Internacional de Atividade Fsica -Forma Curta), fora muscular (fora de preenso manual), desempenho fsico (teste de velocidade de marcha em 4 metros e teste sentar e levantar).A funo cognitiva foi avaliada utilizando o Mini Exame do Estado Mental.Resultados: Foram includos 24 pacientes, com idade mdia de 55,96 (17,1) anos e o tempo mdio de HD de 51,63 (52,6) meses.79,16% participavam de um programa de exerccios fsicos intradialticos.Em relao s variveis independentes, observou-se maior nvel de atividade fsica e melhor desempenho fsico, incluindo fora de preenso manual (FPM).Como desfecho, encontrou-se que a melhor funo cognitiva esteve associadaMarianna Duarte da Conceição; Angélica Nickel Adamoli; Catiussa Colling; Maycon Moura Reboredo; Marvery Peterson Pinheiro Duarte; Heitor S. Ribeiro; Rodrigo Ferrari

Transversal (combinatorics); Motor activity; Cognition; Medicine; Psychology

2026-01-01https://doi.org/10.22491/2357-9730.148505Clinical & Biomedical Research 20261Understanding anthropogenic pressures on freshwater ecosystems: recent trends and emerging issues (2019-2023)Abstract Aim To identify and analyze the most frequently investigated anthropogenic pressures and emerging research themes in freshwater ecosystem studies recently published (between 2019 and 2023). Methods A bibliometric literature review was conducted using the Web of Science and Scopus databases. Articles were selected based on predefined search strings related to freshwater systems and human impacts. A total of 5,549 peer-reviewed articles in English were analyzed using the Bibliometrix package in R®, focusing on abstracts and author keywords to detect trends in stressors, contaminants, ecosystem types, and research collaboration networks. Results Rivers were the most frequently studied ecosystems (4,848 records; 90%), followed by lakes (621; 11%) and wetlands (337; 6%). Agriculture (35%), urbanization (28%), and mining (11%) were the top referenced drivers. Mentions of emerging pollutants grew sharply, with microplastics rising from 19 in 2019 to 198 in 2023, surpassing nutrients and pharmaceuticals. China (3,089), the United States (1,207), Canada (353), and Brazil (309) led in research output, with increasing international collaborations and adoption of advanced tools such as machine learning and remote sensing. Conclusions The literature reveals a growing interest in understanding complex human pressures on freshwater ecosystems. Strengthening international cooperation and integrating policy-oriented research emerge as frequently highlighted strategies in the literature to address these challenges.Layla Mayer Fonseca; Gabrielle Passos Pereira Rosário; André Megali Amado

Wetland; Scopus; Urbanization; China; Microplastics; Freshwater ecosystem; Ecosystem; Environmental resource management; Agriculture; Geography; Environmental planning; Environmental science; Livelihood; Ecosystem services; Environmental protection

2026-01-01https://doi.org/10.1590/s2179-975x11024Acta Limnologica Brasiliensia 20261Fine‐scale patterns of genetic structure in three species of forest birds reveal dynamic Pleistocene history within an Amazonian interfluvePhylogeographical studies of Amazonian birds have revealed large intraspecific diversity, even within recognized areas of endemism. To understand the origin and organization of Amazonian diversity, including the influence of current and historical landscapes, we need to evaluate fine‐scale patterns of genetic diversity in relation to detailed information on environmental heterogeneity. We investigated the phylogeography and demographic history of three understorey bird species, the White‐throated Antbird Oneillornis salvini , the Common Scale‐backed Antbird Willisornis poecilonotus and the Blue‐capped Manakin Lepidothrix coronata , with dense sampling within the Purus–Madeira interfluve, which is part of the Inambari area of endemism. Analysis of sequence data of one mitochondrial (mt)DNA marker and two nuclear markers indicates that species went through recent population expansion and have no genetic structure within the interfluve, even though it includes distinct ecoregions and geological formations. These results suggest a recent occupation of the landscape by current populations, in agreement with geological reconstructions that indicate a dynamic Pleistocene history. For the studied understorey bird populations, biogeographical history is a better predictor of genetic diversity than current environmental heterogeneity within the Purus–Madeira interfluve.Affonso Henrique Nascimento de Souza; Camila Duarte Ritter; João M. G. Capurucho; Juliana Menger; Camila C. Ribas

Phylogeography; Amazonian; Genetic structure; Genetic diversity; Pleistocene; Demographic history; Population; Ecology; Geography; Intraspecific competition; Biology; Environmental niche modelling

2026-03-08https://doi.org/10.1111/ibi.70045Ibis 20261Evaluation of the implementation of pharmaceutical care at the JK School Pharmacy of the Universidade Federal dos Vales do Jequitinhonha e MucuriArtigo: Avaliação da implantação do cuidado farmacêutico na Farmácia Escola JK da Universidade Federal dos Vales do Jequitinhonha e Mucuri Por: Juliana Couto Nascimento, Ana Luiza Cardoso Rocha, Ana Flávia dos Reis Souza, Flávia Santos, Josiane Moreira da Costa, Renata Aline de Andrade, João Victor Marques Teixeira URL: https://revista.fcmmg.br/index.php/REES/article/view/832 Couto Nascimento, J., Cardoso Rocha, A. L., dos Reis Souza, A. F., Santos, F., Moreira da Costa, J., Aline de Andrade, R., & Marques Teixeira, J. V. (2026). Avaliação da implantação do cuidado farmacêutico na Farmácia Escola JK da Universidade Federal dos Vales do Jequitinhonha e Mucuri. Revista De Extensão E Educação Em Saúde Ciências Médicas, 5(2), e832. https://doi.org/10.5281/zenodo.18905006 Faculdade Ciências Médicas de Minas Gerais (FCM-MG). Belo Horizonte, MG/Brasil. Revista de Extensão e Educação em Saúde Ciências Médicas | e-ISSN 2965-6400. https://revista.fcmmg.br/index.php/REES/indexJuliana Couto Nascimento; Ana Luiza Cardoso Rocha; Ana Flávia dos Reis Souza; Flávia Santos; Josiane Moreira da Costa; Renata Aline de Andrade; João Victor Marques Teixeira

Pharmacy; Primary care; Health care; Pharmaceutical care; Humanities; Library science; Gerontology; Medicine

2026-01-01https://revista.fcmmg.br/index.php/REES/article/view/832Open MIND 20261Fabrication of silica-based fiber doped with tungsten nanoparticles for second harmonic generation• We have addressed all the comments listed by reviewers. • Attached is a file called Answer to Reviewers Comments in which we listed how we address all the comments. • We also attached the revised manuscript which we have revised accordingly. A novel silica-based fiber doped incorporating sub-stoichiometric tungsten oxide nanoparticles WO (3−x) was developed to investigate second-order nonlinear optical response, with an emphasis on second harmonic generation (SHG). WO (3−x) nanoparticles were synthesized and incorporated into the silica preform core using a modified chemical vapor deposition (MCVD) process combined with solution doping and subsequent drawn into a fiber. Under 1033 nm femtosecond excitation, both the doped preform and the corresponding fiber exhibited a distinct SHG emission band centered at 517 nm consistent with frequency doubling of the fundamental wavelength. The SHG signal increased with pump power following a predominantly quadratic dependence, confirming a second-order nonlinear mechanism in the WO (3−x) doped silica host. From the measured SHG output, a lower bound for the effective nonlinear coefficient was estimated to be d eff ≥ 2.2 × 10 −5 pm/V. These findings demonstrate the feasibility of WO (3−x) nanoparticle doped silica fibers as a second-order nonlinear processes and guided wave frequency conversion.S.M. Aljamimi; N. Grégoire; V. Anjos; Z. Yusoff; Younès Messaddeq

Second-harmonic generation; Doping; Fabrication; Nonlinear optics; Optical fiber; Femtosecond; Fiber; Nanoparticle; Chemical vapor deposition; Materials science; Optoelectronics; Nanotechnology; Tungsten; Wavelength; High harmonic generation; Harmonic; Optics; Sum-frequency generation; Nonlinear system; Silica fiber; Deposition (geology); Fiber laser

2026-03-09https://doi.org/10.1016/j.yofte.2026.104607Optical Fiber Technology 20261Risk Factors for Falls in Patients on Hemodialysis: A 12‐Month Prospective StudyBACKGROUND: Patients on hemodialysis have comorbidities and malnutrition and are subject to polypharmacy, which contributes to disability and sarcopenia. These conditions increase the risk of falls and are associated with fractures, morbidities, substantial costs, nursing home admissions, hospitalization, and mortality. OBJECTIVE: This prospective study evaluated the association of physical function, postural balance, frailty, fear of falling, and quality of life with the occurrence and number of falls within a 12-month interval in patients on hemodialysis. METHODS: Patients were assessed for physical function (gait speed over 15 ft., timed up and go [TUG] test, 5-repetition sit-to-stand [5-STS] test, and handgrip strength), postural balance (Mini-Balance Evaluation Systems Test [Mini-BESTest]), frailty, fear of falling (Falls Efficacy Scale-International [FES-I]), and quality of life (36-Item Short Form Health Survey [SF-36]). Interviews were conducted for 12 months to monitor falls. RESULTS: One hundred twelve patients were included and the incidence rate was 1.62 falls/person-years. The occurrence of falls was associated with the TUG (OR: 1.24; 95% CI: 1.01-1.53) and 5-STS (OR: 1.11, 95% CI: 1.02-1.21) performance and frailty (OR: 7.22, 95% CI: 1.71-30.50). The number of falls was associated with the gait speed (OR: 0.22; 95% CI: 0.06-0.77), TUG test results (OR: 1.37; 95% CI: 1.16-1.62), handgrip strength (OR: 0.95; 95% CI: 0.91-0.99), Mini-BESTest (OR: 0.87; 95% CI: 0.78-0.96), frailty (OR: 4.43; 95% CI: 1.87-10.51), FES-I score (OR: 1.11; 95% CI: 1.06-1.17), and SF-36 scores in the physical functioning (OR: 0.98; 95% CI: 0.96-0.99), physical role (OR: 0.99; 95% CI: 0.98-0.99), and physical component summary (OR: 0.96; 95% CI: 0.92-0.99) domains. CONCLUSIONS: Patients undergoing hemodialysis have a higher incidence of falls. Falls are associated with physical function, postural balance, frailty, and quality of life.Luciana Angélica da Silva de Jesus; Bruno Valle Pinheiro; Ana Clara Cattete Bainha; Rodrigo Schinniger Assun Garcia; L. Correa; Helena Faria Mucci; Erich Vidal Carvalho; Pelagia Koufaki; Lêda Marília Fonseca Lucinda; Cristino Carneiro Oliveira; Maycon Moura Reboredo

Incidence (geometry); Hemodialysis; Prospective cohort study; Risk factor; Poison control; Population; Quality (philosophy); Quality of life (healthcare); Medicine; Emergency medicine; Physical therapy; Occupational safety and health; Injury prevention; Human factors and ergonomics; Medical emergency

2026-03-10https://doi.org/10.1111/hdi.70068Hemodialysis International 20261Remote work, real effects: the impact of telework on Brazil's sectoral structurePurpose This study aims to examine how teleworkers influence Brazil's economic structure. It shifts the focus from organizational adaptation to the systemic effects on employment, income, and sectoral demand, especially in knowledge-intensive services. Design/methodology/approach The study uses input–output (I–O) analysis with 2021 data, combining national accounts with microdata from household surveys (PNAD-C and POF). The study estimates type II multipliers disaggregated by demographics and uses the hypothetical extraction method to simulate the removal of teleworkers' labor supply and consumption from the economy. Findings The results reveal a structural asymmetry: the Brazilian economy is more sensitive to the withdrawal of teleworkers' consumption than to the withdrawal of their labor supply. Although professional services generate strong employment and income multipliers, technology-driven sectors like systems development create limited indirect jobs. Consequently, teleworkers' systemic weight is predominantly driven by their high-income consumption patterns rather than their role in production chains. Originality/value The paper offers a novel dual perspective, viewing teleworkers as both labor inputs and structural vectors of final demand. Through an empirical analysis, it demonstrates how a concentrated workforce alters sectoral dynamics through consumption patterns, thereby mirroring labor market inequalities within the I–O framework.Pedro Leite; MP Nascimento; Fernando Salgueiro Perobelli

Microdata (statistics); Consumption (sociology); Workforce; Demographics; Mirroring; Production (economics); Sectoral analysis; Inequality; Economics; Labour economics; Business; Economic inequality; Industrial organization; Household income; Productivity; Demographic economics; Private consumption; Sharing economy; Supply and demand

2026-03-09https://doi.org/10.1108/jes-08-2025-0631Journal of Economic Studies 20261Mapping the Concept of Flourishing in Mental Health Research: A Scoping ReviewJuliana Eschiavoni Barboza; Taís Oliveira Silva; Willyane de Andrade Alvarenga; Richard Cowden; Humberto Coelho Schubert; Giancarlo Lucchetti; Juliane Piasseschi de Bernardin Gonçalves; Homero Vallada

Flourishing; Mental health; Thematic analysis; Empirical research; Empirical evidence; Field (mathematics); Psychology; Applied psychology; Social psychology; Qualitative research; Mental model; MEDLINE

2026-01-01https://doi.org/10.2139/ssrn.6265718SSRN Electronic Journal 20261Search for Beyond the Standard Model physics with anomaly detection in multilepton final states in pp collisions at $$\sqrt{s}=13~\textrm{TeV}$$ with the ATLAS detectorAbstract A model-agnostic search for Beyond the Standard Model physics is presented, targeting final states with at least four light leptons (electrons or muons). The search regions are separated by event topology and unsupervised machine learning is used to identify anomalous events in the full 140 fb $$^{-1}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mmultiscripts> <mml:mrow/> <mml:mrow/> <mml:mrow> <mml:mo>-</mml:mo> <mml:mn>1</mml:mn> </mml:mrow> </mml:mmultiscripts> </mml:math> of proton–proton collision data collected with the ATLAS detector during Run 2. No significant excess above the Standard Model background expectation is observed. Model-agnostic limits are presented in each topology, along with limits on several benchmark models including vector-like leptons, wino-like charginos and neutralinos, or smuons. Limits are set on the flavourful vector-like lepton model for the first time.G. Aad; E. Aakvaag; B. Abbott; Sara Abdelhameed; K. Abeling; N. J. Abicht; S. H. Abidi; Mohammed Aboelela; A. Aboulhorma; H. Abramowicz; Y. Abulaiti; B. S. Acharya; A. Ackermann; C. Adam Bourdarios; L. Adamczyk; S. V. Addepalli; M. J. Addison; J. Adelman; A. Adiguzel; T. Adye; A. A. Affolder; Y. Afik; M. N. Agaras; A. Aggarwal; C. Agheorghiesei; F. Ahmadov; S. Ahuja; S. Ahuja; X. C. Ai; G. Aielli; A. Aikot; M. Ait Tamlihat; B. Aitbenchikh; M. Akbiyik; T. P. A. Åkesson; A. V. Akimov; D. Akiyama; N. N. Akolkar; S. Aktas; G. L. Alberghi; J. Albert; Una Helena Alberti; P. Albicocco; G. L. Albouy; S. Alderweireldt; Z. L. Alegria; M. Aleksa; I. N. Aleksandrov; C. Alexa; T. Alexopoulos; F. Alfonsi; M. Algren; M. Alhroob; B. Ali; H. M. J. Ali; S. Ali; S. W. Alibocus; M. Aliev; G. Alimonti; W. Alkakhi; C. Allaire; B. M. M. Allbrooke; D. R. Allen; J. F. Allen; J. F. Allen; P. P. Allport; A. Aloisio; F. Alonso; C. Alpigiani; Z. M. K. Alsolami; A. Alvarez Fernandez; M. Alves Cardoso; M. G. Alviggi; M. Aly; Y. Amaral Coutinho; A. Ambler; C. Amelung; M. Amerl; C. G. Ames; T. Amezza; D. Amidei; Baktash Amini; K. Amirie; A. Amirkhanov; S. P. Amor Dos Santos; K. R. Amos; D. Amperiadou; S. An; C. Anastopoulos; T. Andeen; J. K. Anders; A. C. Anderson; A. Andreazza; S. Angelidakis; A. Angerami; A. V. Anisenkov; A. Annovi; C. Antel; E. Antipov; M. Antonelli

Atlas (anatomy); Lepton; Physics beyond the Standard Model; Standard Model (mathematical formulation); Detector; Atlas detector; Anomaly detection; Physics; Particle physics; Benchmark (surveying); Anomaly (physics); Event (particle physics); Large Hadron Collider; Set (abstract data type); Data set; Collision; ATLAS experiment

2026-03-11https://doi.org/10.1140/epjc/s10052-025-15218-2The European Physical Journal C 20261BOAS PRÁTICAS ADOTADAS PELO TRIBUNAL DE CONTAS DO ESTADO DO AMAZONAS: MECANISMOS DE IMPACTO E EFICIÊNCIA NA GESTÃO PÚBLICAO presente estudo investiga como as metodologias adotadas pelo Tribunal de Contas do Estado do Amazonas (TCE Amazonas) influenciam a análise das Prestações de Contas (PC) e os impactos dessas abordagens na transparência, eficiência e governança pública. O problema central da pesquisa se refere a compreender a efetividade dessas estratégias no aprimoramento da gestão pública e na responsabilização dos gestores. A pesquisa, de natureza bibliográfica e documental, busca identificar e descrever as práticas adotadas pelo TCE Amazonas, analisando documentos oficiais, como relatórios de auditoria e pareceres técnicos, e fontes externas, como reportagens e publicações. A metodologia inclui a revisão de literatura sobre fiscalização, análise documental e análise de conteúdo, com ênfase na mídia e na percepção pública das ações do TCE Amazonas. Os resultados demonstram que essas abordagens melhoram a transparência, fortalecem a governança e contribuem para o controle social. Além disso, o estudo revelou os mecanismos de impacto adotados pelo TCE Amazonas e sua influência na eficiência da gestão pública. A pesquisa também forneceu recomendações para a melhoria contínua das práticas de fiscalização e auditoria, tanto no Amazonas quanto em outros estados.Ellen de Moraes e Silva; Márcia Elaine Dias Pinheiro de Azevedo; Hariela Azevedo Feitoza; Tiago Mesquita Feitoza; Fabiane Saraiva Domingues; Dimis da Costa Braga; Ana Carolina Jansen Pereira Cirino Prado

Public policy; Public management; Political science; Humanities; Philosophy

2026-03-08https://doi.org/10.36557/2674-9432.2026v5n1p2328-2354Periódicos Brasil Pesquisa Científica 20261Noctes Atticae: a etimologia antiga na obra de Aulo Gélio (120-180 d.C.)Este artigo apresenta uma etimologia antiga possível nas Noites Áticas (Noctes Atticae) do jurista latino Aulo Gélio (120-180 d.C.). Sob a luz da Historiografia Linguística (HL), propomos uma análise, a partir de passagens escolhidas da obra, acerca da presença de uma reflexão gramatical no que tange à definição e à origem das palavras, especialmente à utilização de neologismos e ao resgate de arcaísmos à época pelos falantes. Assim, conseguimos apreender uma existência da etimologia antiga enquanto possibilidade de reflexão junto ao contexto historiográfico. Palavras-chave: Aulo Gélio; Noites Áticas; Historiografia Linguística; Etimologia antiga.Raphaella Nasser; Alessandro Jocelito Beccari

Context (archaeology); Historiography; Field (mathematics); Order (exchange); Constitution; Philosophy; Humanities

2026-03-10https://doi.org/10.21165/el.v54i3.3862Estudos Linguísticos (São Paulo 1978) 20261Physicochemical properties, biological activity, and anti-cariogenic potential of a novel sodium fluoride–chitosan gelAbstract This study evaluated the effects of a sodium fluoride–chitosan (NaF/Chit) gel without a crosslinker on Streptococcus mutans biofilm, enamel demineralization, and cell viability. The synthesized 5.6% NaF/Chit gel was characterized by rheological tests (steady and oscillatory shear tests and viscosity), Electrical Impedance Spectroscopy (EIS) to measure impedance modulus, real and imaginary components, admittance, and ion dissociation and Fourier Transform Infrared Spectroscopy (FTIR). Enamel blocks were prepared and assigned to five groups (n = 5): 2.8% Chit, 2.8% NaF, 5.6% NaF/Chit, 1.23% commercial acidulated phosphate fluoride (APF) (positive control), and acetic acid (negative control). S. mutans biofilm were grown for 48 h with daily 1-min applications of each group. The colony-forming units (CFU/mL) and the change in the surface Knoop hardness percentage (%KHN) were assessed before and after biofilm growth. Cytotoxicity was tested using RAW 264.7 cells (MTT assay). The 5.6% NaF/Chit gel showed a rigid and thixotropic profile and higher viscosity than the 2.8% Chit gel. EIS confirmed the ion release of Na + and F − ions from the 5.6% NaF/Chit gel. The 5.6% NaF/Chit, 2.8% Chit, and 2.8% APF groups significantly reduced S. mutans CFU/mL compared with the control groups. The 5.6% NaF/Chit was able to significantly reduce enamel %KHN after biofilm exposure (8.3% KHN) compared to other groups. The 5.6% NaF/Chit IC 50 was 0.086 mg/mL. The 5.6% NaF/Chit gel demonstrated favorable physicochemical characteristics and effective biological activity, significantly reducing S. mutans biofilm and enamel demineralization with low cytotoxicity. The 5.6% NaF/Chit suggests promising clinical potential as a cariostatic biomaterial. Graphical AbstractRanam Moreira Reis; Ângelo Márcio Leite Denadai; Wesley William Gonçalves Nascimento; Jeferson Gomes da Silva; Aline Rogéria Freire de Castilho; Sandra Bertelli Ribeiro de Castro; Eliseu Aldrighi Munchow; Puppin-Rontani Rm; Fabíola Galbiatti de Carvalho

Streptococcus mutans; Enamel paint; Demineralization; Biofilm; Thixotropy; Sodium fluoride; Polyvinylpyrrolidone; Sodium; Chemistry; Nuclear chemistry; Sodium hydroxide; Fourier transform infrared spectroscopy; Fluoride; Acetic acid; Knoop hardness test; Chromatography; Dielectric spectroscopy; Phosphate; Sodium salicylate

2026-03-10https://doi.org/10.1007/s10266-026-01359-7Odontology 20261Assessment of the Relationship Between Communication Apprehension and Attitudes Toward Interprofessional Collaboration Among Student PharmacistsOBJECTIVE: To analyze the relationship between communication apprehension and attitudes toward interprofessional collaboration among student pharmacists. METHODS: An observational study was conducted with student pharmacists from a Brazilian university between March and October 2023. Students answered a questionnaire with the Brazilian version of the Personal Report of Communication Apprehension (PRCA-24), the Jefferson Scale of Attitudes Toward Interprofessional Collaboration (EJARCI), and provided sociodemographic data such as gender, age, course semester, and participation in collaborative activities. The Pearson correlation test and t-test were used. The study was approved by the university's ethics committee. RESULTS: A total of 157 students answered the questionnaire, with 79% being female. No significant correlation was found between communication apprehension and attitudes toward interprofessional collaboration. However, female students showed higher levels of communication apprehension than males. Attitudes toward collaboration tended to improve with age and academic progression. Participation in collaborative activities was associated with lower levels of communication apprehension and more positive attitudes toward collaboration. Specifically, students involved in internships and/or study groups showed a decrease in apprehension and an increase in collaborative attitudes. In contrast, participation in projects was associated only with increased collaborative attitudes. CONCLUSION: Although no significant correlation was found between communication apprehension and interprofessional attitudes, gender differences and the impact of collaborative activities were notable. Educators should address both communication apprehension and interprofessional collaboration in their teaching practices. Students are encouraged to engage in collaborative activities involving other health areas and community settings to develop these essential skills.Yuri Vial Marques de Assis; Anna Júlia de Oliveira Silva; Larissa Torres Fernandes; Dyego Carlos Souza Anacleto de Araújo; Carina Carvalho Silvestre

Apprehension; Pharmacy; Communication apprehension; Pharmacy practice; Qualitative research; MEDLINE; Medical education; Psychology; Nursing; Medicine; Applied psychology

2026-03-10https://doi.org/10.1016/j.ajpe.2026.101967American Journal of Pharmaceutical Education 20261Effectiveness and safety of perampanel in patients with lennox-gastaut syndrome: a single-arm meta-analysis with meta-regression and sensitivity analysesBACKGROUND: Lennox-Gastaut syndrome (LGS) is characterized by multiple types of drug-resistant seizures that usually begin during early childhood and typically include tonic seizures with elevated risks of severe injuries, and are commonly associated with cognitive and behavioral impairments. Perampanel blocks glutamate activity at postsynaptic AMPA receptors and has emerged as a potential therapeutic strategy to disrupt the underlying excitatory mechanisms of this syndrome. OBJECTIVES: To evaluate the effectiveness and safety of perampanel in patients with LGS. METHODS: We conducted a systematic review and meta-analysis following Cochrane guidelines. PubMed, Embase, and Cochrane databases were searched for randomized controlled trials (RCTs) or observational studies. Pooled analyses used single-proportion meta-analysis with 95% confidence intervals (CI). RESULTS: Fourteen studies comprising 330 patients were included. The pooled ≥50% responder rate was 46.5% (95% CI 34-59.2), ≥75% responder rate 21.7% (8.2-38.4), seizure freedom 4.9% (0-15.2), and seizure aggravation 4.4% (0-13). Reported adverse events included somnolence (14.0%), irritability (12%), aggression (10.8%), dizziness (5.2%), agitation (3.9%), and psychiatric symptoms (15.1%). Heterogeneity was substantial. CONCLUSION: Perampanel demonstrates clinically meaningful seizure reduction in LGS with modest seizure-freedom and a behaviorally skewed safety profile. Despite heterogeneity and mostly retrospective data, findings support adjunctive use and highlight the need for larger, high-quality RCTs.Amanda Alves Rabelo; Júlia Fraga Castro e Oliveira; Yasmim De Souza Nunes; Carolina Alves Corrêa; Daniel Correa de Castro; GABRIELA DAS GRAÇAS DOS SANTOS CAROLINO; Bernhard J. Steinhoff

Perampanel; Sensitivity (control systems); Epilepsy; Adverse effect; MEDLINE; Medicine; Anesthesia; Internal medicine; Intensive care medicine

2026-03-11https://doi.org/10.1016/j.yebeh.2026.110972Epilepsy & Behavior 20261Technical evolution of concrete in Brazil: a six-decade study (1960s–2020s)Juliana Fadini Natalli; Laís Cristina Barbosa Costa; Julia Castro Mendes; Marina Altoé Caetano; Paulo Ricardo de Matos; Alexandre Araújo Bertini; Ricardo André Fiorotti Peixoto

Work (physics); Process (computing); Feature (linguistics); Welding; Engineering; Forensic engineering

2026-03-11https://doi.org/10.1007/s41024-025-00736-zJournal of Building Pathology and Rehabilitation 20261Examination of Coligands in Mefloquine–Metal Complexes Reveals the Structural Determinants of Activity against Plasmodium falciparum and Schistosoma mansoniHigh Resolution Image Download MS PowerPoint Slide Mefloquine (MQ) is an important component for antiparasitic therapy. Herein, the synthesis and antiplasmodial and antischistosomal activities of MQ–metal complexes of the general formula [M(II)(L)(MQ)]PF 6 are described. Variation of the metal center (platinum and palladium) and coligand (phosphine or bipyridine) consistently yielded MQ coordinated as a N, O -bidentate ligand. Biological evaluation against Plasmodium falciparum and Schistosoma mansoni revealed that the metal center augmented the antiparasitic property of MQ by functioning as a thioredoxin/glutathione reductase-targeting moiety, while the coligand modulated chemical reactivity and physicochemical properties. MQ–Pt complexes displayed high in vivo efficacy. The intracellular accumulation of the metal in parasite cells contributed to the abrogation of essential biochemical pathways. Notably, despite being isostructural, Pd complexes differed from their Pt counterparts in their ligand dissociation behavior. The current work establishes a new structural framework for developing metal-based antiparasitic agents capable of selectively targeting essential parasite biochemical pathways while sparing mammalian cells.Wilmer Villarreal; Helenita Costa Quadros; Legna Colina-Vegas; Sammy Y Aboagye; Godwin Akpeko Dziwornu; Gabriel H. Ribeiro; Ariane Isis Barros; Dawid Jakub Kucharski; Mahsa Rahbari; Christina Brandstädter; Sarah D’Alessandro; Nicoletta Basilico; Keabetswe Masike; Nandi Mehlala; J. Araújo e Nobrega; Victor M. Deflon; Maribel Navarro; Przemysław J. Boratyński; Kelly Chibale; David L. Williams; Alzir A. Batista; Diogo R. M. Moreira

Antiparasitic; Antiparasitic agent; Intracellular; Metal; Structure–activity relationship; Plasmodium falciparum; Ligand (biochemistry); Biological activity; Chemistry; Stereochemistry; Biochemistry; Combinatorial chemistry; Dissociation constant; Intracellular parasite; Parasite hosting

2026-03-11https://doi.org/10.1021/acs.jmedchem.5c03739Journal of Medicinal Chemistry 20261Previsão mensal de vazão para o rio JequitinhonhaStreamflow forecasting is pivotal for mitigating socio‑economic risks and optimizing water‑resources operations, whose inherent variability affects energy production, public supply, and extreme‑event management. Aiming to bridge the national research gap on machine‑learning applications to the Jequitinhonha River, this study developed a CatBoost model capable of delivering reliable monthly forecasts. Daily discharge observations served to train the model, and 31‑day (one‑month) ahead predictions were evaluated with MAPE, RMSE, and KGE, together with 5th–95th‑percentile prediction intervals. The baseline configuration yielded a MAPE of 15.7 %, an RMSE of 26.7 m³/ s, and a KGE of 0.36; expanding the lag window subsequently improved the KGE to 0.54, while the 90 % prediction interval satisfactorily encompassed the observed values. CatBoost thus proved adept at reproducing the Jequitinhonha’s flow regime, yet further advances will depend on longer time series and refined hyperparameter tuning to enhance correlation and diminish bias, consolidating the approach as a promising decision‑support tool for regional water‑resources management.Welson de Avelar Soares Filho; Paula Roberta Souza Carvalho; Celso Bandeira de Melo Ribeiro; Leonardo Goliatt da Fonseca

Baseline (sea); Mean squared error; Lag; Hyperparameter; Interval (graph theory); Bridge (graph theory); Time series; Correlation coefficient; Engineering; Environmental science; Statistics

2026-01-27https://doi.org/10.59824/rmrh.v7.358Revista Mineira de Recursos Hídricos 20261Socio-agronomic features define the structure of socioecological seed exchange network and “on farm” conservation of agrobiodiversity in quilombola communities in BrazilBACKGROUND: Traditional agricultural systems are rooted in the local management, selection, and conservation of agrobiodiversity. Understanding the socioecological dynamics that sustain these systems is essential for developing sustainable practices that ensure food security and sovereignty in the territories of traditional and Indigenous peoples. This study assessed the role of seed exchange networks in on-farm agrobiodiversity conservation in quilombola communities in Brazil that face environmental and political threats. We emphasize the role of socioecological networks and socio-agronomic variables in shaping how agrobiodiversity is maintained, shared, and regenerated across time and space. METHODS: We conducted semi-structured interviews, free listing, participant observation, and guided tours with 48 agrobiodiversity management units (AMUs) from five communities, documenting socio-agronomic variables and ethnovariety richness with botanical identification in the field and literature. We recorded all ethnovarieties shared among internal AMUS - living in the quilombola communities, and external AMUs - outside the territory. We then sorted 15 ethnovarieties per internal AMUs to collect data on seed exchange interactions. Further, we registered data on socio-agronomic variables, ethnovarieties richness, and seed flows (donation and reception) to analyse the properties of AMUs (nodes in the network) and seed exchange patterns in the network, and assess their potential for conserving agrobiodiversity. RESULTS AND DISCUSSION: We documented a total of 359 ethnovarieties. The complete and open network was formed by 185 AMUs - 48 internal and 137 external - which realized 424 events of seed exchanges. Agro-environmental diversity, cultivated area, and the period living in the community were positively associated with AMUs' richness and its centrality in the network, highlighting their role as agrobiodiversity guardians and network bridges. The seed exchange network displayed low nestedness, low connectance, and high modularity, indicating the formation of cohesive subgroups of AMUs with strong exchanges among specific partners and limited intergroup seed flows. These findings reflect social segregation and reveal vulnerabilities, as varieties unevenly distributed across modules may not circulate widely, reducing agrobiodiversity resilience. CONCLUSIONS: We argue that historical and material conditions are critical for sustaining on-farm agrobiodiversity conservation in quilombola territories. Land tenure security and territorial rights are essential for maintaining traditional agroecosystems that integrate ecological knowledge, cultural heritage, and biodiversity management. Strengthening seed exchange connectivity, fostering collaboration across groups - from inside and outside territories - are urgent actions to enhance resilience, safeguard traditional knowledge, and ensure long-term biocultural justice.Isabella Fernandes Fantini; Gustavo Taboada Soldati; Fernanda Vieira da Costa; Thiago da Silva Novato; Fátima Regina Gonçalves Salimena

Agricultural biodiversity; Biodiversity; Agroecosystem; Biodiversity conservation; Food security; Safeguard; Commodification; Traditional knowledge; Agroforestry; Geography; Environmental resource management; Ecology; In situ conservation; Land use; Environmental planning; Agriculture; Business; Sustainability

2026-03-11https://doi.org/10.1186/s13002-025-00847-4Journal of Ethnobiology and Ethnomedicine 20261β-Cyclodextrin-Based Encapsulation of Mitracarpus frigidus Extract Enhances Antifungal Activity Against Candida sppThalita de Freitas Souza; Thayná Gomes Ferreira; Ana Bárbara Polo; Ari S.O. Lemos; Priscila L. Paula; Matheus Torres Branca; Gianluigi Lazzarini; Débora Almeida de Oliveira; Lívia R. Gamarano; Núbia Benini Andrade; Caio Juan Silva Fortes; Gustavo Lucas da Silva Lima; Ângelo Denadai; Rodrigo Furlan Silva Fabri

Candida albicans; Antimicrobial; Antifungal; Minimum inhibitory concentration; Antifungal drugs; Corpus albicans; Zeta potential; Solubility; Chemistry; Microbiology; Traditional medicine; In vitro; Stigmasterol

2026-01-01https://doi.org/10.2139/ssrn.6380338SSRN Electronic Journal 20261Integrated Cloud and Hardware-in-the-Loop Framework for IoT-Based Control and MonitoringThis work introduces a Cloud-in-the-Loop approach that combines Internet of Things (IoT) devices with Hardware-in-the-Loop simulation for testing control and monitoring applications. The proposed architecture employs a three-level hierarchical structure: the first level simulates the Battery Energy Storage System and local power flow control on a Digital Sampling Processor microcontroller, the second level uses an ESP32 microcontroller for Controller Area Network (CAN) communication and data transmission to the cloud, and the third level, implemented with an online broker, enables data storage, analysis and commands. A simplified power flow model and a battery model representation are considered to evaluate long-term operation with one year of climate and load data. Two load management strategies were compared: (i) total load shedding at 0% State of Charge, and (ii) hierarchical load disconnection at predefined SOC thresholds. Results showed that the hierarchical strategy increased the average State of Charge by 25.2% (54.66% vs. 43.64%), prevented interruptions to critical loads. The results show that the proposed framework serves as a flexible step before real deployment, since its cloud-based functions remain unaltered while only the physical hardware is replaced. This approach reduces implementation problems and allows the methodology to be extended to various case studies.Diuary Gonçalves; Ives De O. Furtado; Allan F. Cupertino; Heverton Augusto Pereira; Remus Teodorescu

Microcontroller; Cloud computing; Battery (electricity); Controller (irrigation); State (computer science); Data transmission; State of charge; Representation (politics); CAN bus; Control (management); Computer science; Real-time computing; Embedded system; Distributed computing; Transmission (telecommunications); Flow control (data); Data flow diagram; Load Shedding; Power (physics); Energy management; Power management

2026-03-12https://doi.org/10.18618/rep.e202616Eletrônica de Potência 20261Power Flow-Based Estimation of Short-Circuit Currents From Inverter-Based ResourcesThe generator side of inverter-based resources (IBRs) interfaced with back-to-back converters is electrically decoupled from the grid. During electrical faults, grid-following IBRs behave as voltage-dependent current sources due to grid code requirements and converter control. This paper presents Newton-Raphson formulations for estimating short-circuit currents from IBRs using novel power flow modeling approaches to address voltage-dependent current sources. The work shows how to representdq0current injections, which are typically implemented in control architectures based on phase-locked loops. The power flow formulations are adapted to capture grid codes with different characteristics, such as the injection of negative-sequence currents during unbalanced faults. Comparisons against a field-validated electromagnetic transients (EMT) model reveal mean absolute errors of less than 0.5% for the proposed approach when estimating steady-state short-circuit currents from type IV wind turbine generators under grid-following control.Ramon Abritta; Gabriel M. G. Guerreiro; Alexey Pavlov; B. Børresen; Elisabetta Tedeschi; Ranjan Sharma; Ivo Chaves da Silva

Power (physics); Estimation; Noise (video); Control theory (sociology); Current (fluid); Computer science

2026-01-01https://doi.org/10.1109/oajpe.2026.3673646IEEE Open Access Journal of Power and Energy 20261Suporte Social, Resiliência e Bem-Estar no Trabalho de Motoristas de ÔnibusO trabalho noturno impõe desafios ao bem-estar dos trabalhadores, especialmente em ocupações com longas jornadas, altas demandas e riscos psicossociais. Este estudo investiga relações entre suporte social, resiliência e bem-estar no trabalho (BET) em motoristas de ônibus dos turnos diurno e noturno no estado do Rio de Janeiro. Adotou-se delineamento transversal, quantitativo, correlacional e comparativo. Participaram 219 motoristas avaliados por instrumentos validados: Escala de Bem-Estar no Trabalho, Escala de Resiliência CD-RISC-10 e Escala Multidimensional de Suporte Social Percebido. As análises foram realizadas no software JASP, incluindo estatísticas descritivas, teste de normalidade, correlações, Análise Fatorial Confirmatória e Modelagem de Equações Estruturais. A comparação entre turnos utilizou o teste U de Mann-Whitney. Os resultados indicaram níveis significativamente menores de bem-estar entre motoristas noturnos, associados a alterações do ritmo circadiano. Observou-se associação robusta entre suporte social e resiliência, sendo a resiliência preditora do BET e mediadora dessa relação, com implicações relevantes à saúde.Alexandre da Silva Teixeira; Ana Lucia Mendes Teixeira; Luís Antônio Monteiro Campos; Alberto Abad

Test (biology); Work (physics); Scale (ratio); Field (mathematics); Data collection; Field research; Psychology; Humanities; Social psychology; Applied psychology

2026-03-12https://doi.org/10.58210/rie3746Revista Inclusiones 20261CarboFarm: Data Integration and Knowledge Generation for Agricultural GHG InventoriesLuiz Fernando SANTOS; Regina Braga; José Maria David; Victor Ströele

Greenhouse gas; Decision support system; Data integration; Work (physics); Agriculture; Knowledge extraction; Big data; Knowledge-based systems; Knowledge integration; Computer science; Climate change; Business; Global warming; Environmental economics; Sustainable development; Environmental resource management; Land use; System integration; Information integration

2026-03-12https://doi.org/10.21203/rs.3.rs-8768135/v1Research Square 20261Jabuticaba (Myrciaria cauliflora) Modulates Intestinal Inflammation, Liver Homeostasis, and Brain Gene Expression Along the Gut–Liver–Brain Axis in a DSS-Induced In Vivo ModelBackground/Objectives: Dextran sulfate sodium (DSS) is widely used to induce intestinal injury, reducing intestinal barrier integrity and thus contributing to systemic inflammation and oxidative stress, which may affect liver homeostasis and central nervous system function. In this context, the intake of phenolic compounds and anthocyanins from fruits such as jabuticaba has gained attention due to their antioxidant and anti-inflammatory properties. This study evaluated the effects of jabuticaba in the form of freeze-dried whole fruit, freeze-dried peel, and microencapsulated peel extract on DSS-induced damage to the gut–liver–brain axis in an in ovo model. Methods: Fertile eggs were assigned to five groups: water, DSS, DSS plus whole jabuticaba (WJ), DSS plus jabuticaba peel (JP), and DSS plus microencapsulated jabuticaba peel (JM). Duodenal, colon, and liver gene expressions; and histomorphometry, cecal microbiota, and brain gene expressions were evaluated at hatch. Results: DSS administration increased NF-κB expression and reduced MUC-2 in the duodenum, induced colonic inflammation, altered cecal microbiota, and caused hepatic oxidative stress, evidenced by elevated iNOS and enlarged fat globules, while reducing brain BDNF levels. Jabuticaba treatments mitigated intestinal, hepatic, and neural damage by reducing inflammatory markers; enhancing MUC-2, ZO-2, JAM-2, and claudin-1 expression; increasing villus area and goblet cell numbers; normalizing CAT and SOD activities in the liver; decreasing COX-2; increasing dopamine; and restoring BDNF in the brain. Conclusions: This study demonstrates that jabuticaba exerts protective effects along the gut–liver–brain axis, highlighting its potential as a functional food to support intestinal, hepatic, and brain health.Stephanie Michelin Santana Pereira; Vinícius Parzanini Brilhante de São José; M. H. Huang; LÍVYA ALVES OLIVEIRA; Kelly Aparecida Dias; Júlia d’Almeida Francisquini; Ítalo Tuler Perrone; Ceres Mattos Della Lúcia; Elad Tako

Gene expression; In vivo; Oxidative stress; Inflammation; Central nervous system; Antioxidant; Occludin; Oxidative phosphorylation; Chemistry; Endocrinology; Internal medicine; Pharmacology; Homeostasis; Mucin 2; Intestinal mucosa; Prebiotic

2026-03-12https://doi.org/10.3390/nu18060903Nutrients 20261Revisão sistemática da literatura sobre Terapia Cognitivo-Comportamental em Grupo para Mulheres Vítimas de Violência por Parceiros ÍntimosO artigo apresenta uma revisão sistemática sobre intervenções grupais baseadas na Terapia Cognitivo-Comportamental (TCC) direcionadas a mulheres vítimas de violência por parceiros íntimos, com o objetivo de examinar a estrutura das intervenções, além das estratégias e técnicas terapêuticas empregadas. A pesquisa, realizada nas bases Web of Science e BVS, utilizou a combinação das palavras-chave “Terapia de Grupo” AND “Violência por parceiro íntimo”, “Terapia de Grupo Cognitivo-Comportamental” AND “Violência por parceiro íntimo” e “Psicoterapia de Grupo” AND “Violência por parceiro íntimo”, analisando treze estudos publicados nos últimos dez anos. Observou-se o uso consistente de estratégias como psicoeducação das emoções, técnicas voltadas para a melhora da autoestima, habilidades sociais, atenção plena e tratamento de transtornos psicológicos recorrentes nesse grupo, especialmente o Transtorno de Estresse Pós-Traumático. A análise reforça o papel das intervenções grupais, em contextos com elevada prevalência de violência contra mulheres, como ferramentas essenciais nas políticas de saúde pública.Stela Silva Carvalho; Lélio Moura Lourenço

Exploratory analysis; Population; Yield (engineering); Congenital disease; Medicine

2026-03-11https://doi.org/10.31505/rbtcc.v27i1.2075Revista Brasileira de Terapia Comportamental e Cognitiva 20261Fenton Treatment of Filter Backwash Water for Recycling in DWTPABSTRACT Drinking water treatment plants (DWTPs) generate residues, such as filter backwash water (FBW), that can harm the aquatic environments if discharged into water sources. In this sense, FBW recycling has gained attention. Nevertheless, it requires treatment to maintain operational efficiency and water quality in the DWTP. This work analyzed the main variables interfering with Fenton treatment of FBW from a full‐scale DWTP aiming at removing turbidity and microorganisms. Bench‐scale tests successfully inactivated 100% of Escherichia coli . Desired removal of other parameters (99.1% of turbidity, 99.9% of color, and achieving a 2.5 log 10 reduction of aerobic endospores) occurred during the sedimentation stage. There was a strong influence of the pH sample and the concentration of added hydrogen peroxide on the removal of microorganisms. This study represents an initial stage that should be continued to enable the removal of resistant microorganisms through oxidation by the Fenton reaction in FBW treatment.Luana Valverde Pereira; Matheus Carlos de Sá; Isabella Pereira de Lima; Lucas Coelho Rossi; Taciane de Oliveira Gomes de Assunção; Edgard Henrique Oliveira Dias; Sue Ellen Costa Bottrel; Renata de Oliveira Pereira

Turbidity; Water treatment; Hydrogen peroxide; Filter (signal processing); Water quality; Sedimentation; Sand filter; Degradation (telecommunications); Chemistry; Pulp and paper industry; Environmental science; Environmental chemistry; Wastewater; Portable water purification; Sewage treatment; Environmental engineering; Coagulation; Waste management; Decantation; Suspended solids

2026-03-01https://doi.org/10.1002/wer.70337Water Environment Research 20261Ultrasound pretreatment promotes modifications in the structure and techno-functional properties of powdered goat milk kefir produced by spray drying and freeze-dryingFlaviana Coelho Pacheco; Ana Carolina Campos Dias; Analice Aparecida Vitoria Sipriano; Juliana de Cássia Gomes Rocha; Dirceu Santhiago Trindade; Maria Eduarda Silveira Faria; Irene Andressa; Hiasmyne Silva de Medeiros; José Antônio de Queiroz Lafetá; Paulo Henrique Costa Paiva; Ana Flávia Coelho Pacheco

Spray drying; Kefir; Ultrasound; Dairy industry; Particle size; Rheology; Chemistry; Food science; Chromatography; Chemical engineering

2026-03-13https://doi.org/10.1016/j.idairyj.2026.106624International Dairy Journal 20261BIOACTIVE CHITOSAN FILMS INCORPORATED WITH COPAIFERA OFFICINALIS OLEORESINOral infections, especially in immunocompromised patients, represent a growing therapeutic challenge due to antimicrobial resistance and the limited availability of effective topical alternatives. This study aimed to develop and characterize bioactive chitosan (CH)-based films incorporated with copaiba oleoresin (COR) to contribute to the treatment of oral diseases. Polymeric films containing CH incorporated with different COR concentrations (0.5%, 1%, and 3.5%) were formulated and characterized using Raman and FT-IR spectroscopy. Moisture, swelling, and solubility were evaluated. Cytotoxicity was tested in J774A.1 cells (MTT assay). COR was previously analyzed by GC-MS and subsequently tested for Minimum Inhibitory Concentration (MIC) and Minimum Microbicidal Concentration (MMC) against 17 pathogens of oral relevance. The CH–COR combination was evaluated by the checkerboard method (Fractional Inhibitory Concentration Index, FICI) and biofilm inhibition assay. Spectroscopic analysis confirmed the presence of bioactive compounds with known antimicrobial properties, such as β-caryophyllene and diterpenic acids. COR exhibited MIC values between 26.04–46.87 µg/mL, and CH between 0.1–0.8 mg/mL. The combination demonstrated a synergistic effect against Streptococcus oralis (ATCC 10557) and an additive effect against other strains tested, with bactericidal action and satisfactory inhibition of biofilm formation, with values close to azithromycin control. The films presented moisture content ranging from 15.24% to 20.23%, with lower humidity at higher COR concentrations. Swelling was higher during the first hours, suggesting an ideal dressing replacement around 10 hours. Solubility ranged from 94.1% to 96.5%, which may compromise sustained release. The cytotoxicity of the films was inconclusive due to physical interference in the assay; however, isolated COR was safe and promoted cell growth, and CH demonstrated biocompatibility. CH–COR films exhibited promising physicochemical properties, good initial absorption, high solubility, and antimicrobial potential due to the active compounds incorporated into the matrix. The combination showed synergism against oral pathogens and effective biofilm inhibition, making it a promising candidate for managing oral infections. Further studies are needed to optimize evaluation methods and ensure clinical safety and efficacy.Taleessa Vieira Gomes; Ana Bárbara Polo; Beatriz Vilela Tomé; Daphne F Coppoli Lanferini; Antônio Carlos Sant’Ana; Ana Carolina Morais Apolônio; Laura Lima de Queiroz; Sabrina França Silva; Diogo Montes Vidal

Oleoresin; Officinalis; Chitosan; Calendula officinalis; Folk medicine; Chemistry; Traditional medicine; Food science

2026-03-01https://doi.org/10.1016/j.bjid.2026.104670The Brazilian Journal of Infectious Diseases 20261EVALUATION OF THE ANTIMICROBIAL ACTIVITY OF CORDIA VERBENACEA ESSENTIAL OIL AGAINST DIFFERENT CLINICALLY RELEVANT PATHOGENSThe growing resistance to conventional antimicrobials represents a global public health challenge, encouraging the search for effective and safe therapies. In this context, essential oils have stood out due to their antimicrobial activity, with reduced microbial resistance during their use against pathogens. This study aimed to evaluate the antimicrobial activity of Cordia verbenacea essential oil (EO) against clinically relevant pathogens. The antimicrobial activity was assessed through Minimum Inhibitory Concentration (MIC) and Minimum Microbicidal Concentration (MMC) assays of the EO. The microbial strains included Acinetobacter baumannii (ATCC 19606); Candida albicans (INCQS 40175); Candida tropicalis (ATCC 750); Enterococcus faecalis (ATCC 51299); Enterococcus faecium (ATCC 6569); Klebsiella pneumoniae (ATCC 700603 and BAA 2814); Pseudomonas aeruginosa (INCQS 2742); Staphylococcus aureus (ATCC 29213 and ATCC 33591); Streptococcus mutans (ATCC 25175); Streptococcus oralis (ATCC 10557). MIC and MMC values were determined by the broth microdilution method in Mueller-Hinton broth (MH), following CLSI (2022) guidelines, with visual evaluation of microbial growth and confirmation of microbicidal activity on Brain Heart Infusion (BHI) agar. Tested concentrations ranged from 30 to 0.23 mg/mL, and bacterial and fungal inocula were standardized by McFarland scale at 0.5 × 10⁵ CFU/well and 0.5 × 10³ CFU/well, respectively, with incubation under conditions specific for each microorganism. After MIC testing, it was observed that the EO showed inhibitory activity at 30 mg/mL for S. aureus (ATCC 33591), 25 ± 8.66 mg/mL for E. faecium , 20 ± 8.66 mg/mL for A. baumannii and C. tropicalis , 15 mg/mL for C. albicans and S. aureus (ATCC 29213), 15 ± 7.5 mg/mL for E. faecalis , 0.5 ± 0.42 mg/mL for S. mutans , and greater than 30 mg/mL for the remaining strains. The MMC assay showed that its activity was microbiostatic. The EO demonstrated inhibitory activity at concentrations ranging from 30 to 0.5 mg/mL against the tested microorganisms, but no activity against K. pneumoniae and P. aeruginosa at the tested concentrations. Thus, EO represents a promising natural alternative for the control of clinically relevant pathogens, especially in light of the advance of microbial resistance.Vitória Batista Clemente; Luciana Cláudia Diniz Tavares; Cássia Pereira da Silva; Marília Ulhoa Soares; Amanda Marota de Oliveira; Ana Carolina Morais Apolônio

Essential oil; Antimicrobial; Antibiotics; Medicinal plants; Pathogenic bacteria; Traditional medicine; Medicine; Biology

2026-03-01https://doi.org/10.1016/j.bjid.2026.104641The Brazilian Journal of Infectious Diseases 20261ANTIMICROBIAL ACTIVITY OF ESSENTIAL OILSMicrobial resistance has a major impact on infection control. In this context, the antimicrobial activity of essential oils has gained prominence in modern research, being fundamental to guide their use and to combat microbial resistance. Thus, this study aimed to determine the minimum inhibitory concentration (MIC) and minimum microbicidal concentration (MMC) of four essential oils – Ocimum gratissimum (clove basil), Lantana trifolia (capiçoba), Schinus terebinthifolius (Brazilian peppertree), and Siparuna guianensis (negramina) — against bacterial and fungal strains ( Staphylococcus aureus, Streptococcus sobrinus, Candida tropicalis, Cutibacterium acnes ). Antimicrobial activity was evaluated by the broth microdilution method in Mueller Hinton broth, according to the Clinical and Laboratory Standards Institute (CLSI, 2022) protocol. Tested concentrations ranged from 30 to 0.23 mg/mL. Dimethyl sulfoxide (DMSO) was used as a solvent control and azithromycin (40 µg/mL) as a positive control. Microbial inocula were prepared from the 0.5 McFarland scale and serial dilutions, resulting in concentrations of 0.5 × 10⁵ CFU/mL (bacteria) and 0.5 × 10³ CFU/mL (fungi). After incubation at 37°C for 24 h, the MIC was defined as the lowest concentration that visually inhibited growth. The MMC was determined by plating inhibited wells on BHI agar followed by re-incubation. The four essential oils tested showed variations in antimicrobial activity. Clove basil was the most effective, with MICs between 3.75 and 7.5 mg/mL for all microbial strains. Oils from Brazilian peppertree and negramina showed less expressive activity against this group of microorganisms, with MICs often above 30 mg/mL. Capiçoba oil had variable performance, with good responses against some strains. Overall, the comparison between MIC and MMC indicated a predominant microbicidal effect in the most active oils. The essential oils tested demonstrated in vitro antimicrobial activity, with emphasis on O. gratissimum . Further studies, including in vivo models, are recommended to better evaluate the potential of these natural compounds.Amanda Marota de Oliveira; Matheus Fernandes Lasneau Moraes; Maria Clara Guimarães de Siqueira; Tharcisio Amadeu Tomaz Caetano; Mariana Simões de Oliveira; Ana Carolina Morais Apolônio

Antimicrobial; Broth microdilution; Ocimum; Essential oil; Ocimum gratissimum; Minimum inhibitory concentration; Agar; Microbiology; Biology; Food science; Traditional medicine; Baccharis; Bacterial growth; Minimum bactericidal concentration

2026-03-01https://doi.org/10.1016/j.bjid.2026.104637The Brazilian Journal of Infectious Diseases 20261SUSCEPTIBILITY PROFILE TO PLANT EXTRACTS OF CANDIDA SPP. ISOLATES FROM URINE IN RECENT YEARS IN A UNIVERSITY HOSPITAL OF MINAS GERAISIn the hospital environment, several factors that lead to microbial dysbiosis contribute to the development of fungal infections caused by yeasts of the genus Candida , with the emergence of resistance already documented. Plant extracts have become potential sources for the discovery of bioactive compounds with antimicrobial activity, as new alternatives for the treatment of antifungal-resistant infections are urgently needed. The objective of this study was to evaluate the antifungal potential of plant extracts against Candida species resistant to commercial antifungal agents, isolated from urine samples of hospitalized patients with candiduria in a university hospital in Minas Gerais. Yeasts were isolated and identified between March 2021 and January 2023. For yeasts resistant to one or more commercial antifungal agents, susceptibility tests were carried out using five different plant extracts ( Amaranthus viridis , Stachys lanata , Glycyrrhiza inflata , Pothomorphe umbellata , and Renealmia petasites ) in serial concentrations, by broth microdilution technique, to determine the minimum inhibitory concentration (MIC) of the extract capable of inhibiting fungal growth. Between 2021 and 2023, 42 yeast isolates of different species showed resistance to one or more tested antifungal drugs and were recovered to evaluate the antifungal potential of the plant extracts. The MIC value was higher than the maximum concentration tested (> 1000 µg/mL) for four of the five extracts ( R. petasites , S. lanata , A. viridis , and G. inflata ), suggesting that these did not show significant activity against Candida strains resistant to commercial antifungals. Only the extract of P. umbellata showed moderate inhibitory and fungicidal activity against some Candida strains (26.2%), including 5 strains of C. glabrata (19.2%), 5 strains of C. parapsilosis (71.4%), and one strain of C. kefyr (100%). This study identified a potential antifungal activity for the P. umbellata extract, which remains to be further explored. This finding reinforces the importance of searching for active molecules and potential new drugs, which may provide alternatives to overcome therapeutic limitations, poor bioavailability, and toxicity of current antifungals, as well as the increasing resistance among fungal species.Laura Lavorato Soldati; João Joaquim de Matos; Larissa Negrão Rebelo de Almeida; Maria de Lourdes Junqueira; Caroline Priamo Gama; Danilo de Souza Costa; Ademar Alves da Silva Filho; Francis Moreira Borges; Priscila de Faria Pinto

University hospital; Urine; Antibiotics; Population; Outbreak; Medicine; Microbiology; Biology

2026-03-01https://doi.org/10.1016/j.bjid.2026.104703The Brazilian Journal of Infectious Diseases 20261INTRAORAL DEVICES AS POTENTIAL RESERVOIRS OF PATHOGENS: EFFECT OF ACRYLIC RESIN MANUFACTURING TECHNIQUE, PRINTED AND MILLED ON SUSCEPTIBILITY TO POLYMICROBIAL BIOFILM COLONIZATIONBiofilm development on intraoral devices represents a relevant challenge in clinical practice, especially in immunocompromised patients or those at increased risk of opportunistic infections. We evaluated the influence of surface properties of acrylic resins used in the fabrication of occlusal splints on biofilm formation derived from human saliva, as a representative model of the complexity of oral microbiota. Cylindrical acrylic resin (PMMA) specimens (4.0 × 1.5 mm) were fabricated under three conditions: heat-polymerized (RAT group, control), milled (RAF group), and 3D-printed (RAI group), with n=120 per group. After standardized finishing and polishing, surface free energy (contact angle, θ), roughness (Ra), total biofilm quantification, biofilm extracellular matrix, and surface morphology by scanning electron microscopy (SEM) were evaluated. Statistical analysis used ANOVA with Tukey’s test for physicochemical data and the Mann-Whitney test for microbiological variables (α=0.05). The RAI group had a significantly more hydrophilic surface (55.10 ± 5.82°) than RAF (73.30 ± 4.71°) and RAT (71.70 ± 4.08°) (p<0.001). Although roughness was similar among RAT (13.3 ± 1.44), RAI (13.8 ± 1.52), and RAF (16.1 ± 1.78) (p=0.067), biofilm formation was significantly higher in RAI from day 4 onwards (0.53 ± 0.2) (p<0.05), with marked production of carbohydrate-rich extracellular matrix, which was absent in RAF. The RAF group remained less susceptible to microbial colonization over six days of incubation. SEM images showed that biofilm formation varied according to resin type: RAI had the highest number of bacterial cells at all three time points; RAF showed greater morphological diversity on day 4; and RAT had overall lower colonization, although with an increase on day 4. Manufacturing method influences biofilm formation on PMMA intraoral devices, with relevant implications for the prevention of device-associated infections. 3D printing generates surfaces more prone to bacterial adhesion and extracellular matrix accumulation, potentially representing a risk factor for persistent infections in the oral environment, whereas milling appears to be a more suitable alternative from the standpoint of microbial control.Matheus Fernandes; Rafaela Ladeira Bonato; Beatriz Vilela Tomé; Mariana Simões de Oliveira; Laisa Araújo Cortinês Laxe; Ana Carolina Morais Apolônio

Biofilm; Acrylic resin; Colonization; Manufacturing process; Chemistry; Composite material; Materials science

2026-03-01https://doi.org/10.1016/j.bjid.2026.105004The Brazilian Journal of Infectious Diseases 20261INTEGRATED TUTORED LEARNING SYSTEM: DESCRIPTION OF AN INNOVATIVE PRACTICAL TEACHING MODEL IN THE CARE OF PEOPLE LIVING WITH HIV/AIDSThe 2014 National Curriculum Guidelines (DCN) established active methodologies as fundamental in medical education. The Charles Maguerez arc method and peer learning have emerged as innovative pedagogical strategies in teaching care for people living with HIV/AIDS (PLWHIV). To describe the development and implementation of the Integrated Tutored Learning System (SIAT) in practical teaching of care, treatment, and follow-up for PLWHIV. Descriptive development study of SIAT, a model based on peer learning combined with the arc method, implemented in a specialized HIV/AIDS outpatient clinic in Juiz de Fora. Thirty-four students from the 2nd to the 12th semesters participated, organized in pairs (beginners and advanced), supervised by a specialist tutor. The dynamics followed five stages: observing HIV/AIDS cases, identifying key points, theorizing clinical management, discussing therapeutic hypotheses, and peer teaching. A final anonymous evaluation of the experience was applied. Significant student engagement was observed in practical HIV/AIDS activities. Advanced students developed theoretical summaries and care checklists, while beginners showed active curiosity about clinical management. Integration across basic, clinical, and internship cycles enriched the educational experience. Students reported stronger consolidation of HIV/AIDS knowledge, easier theoretical understanding after practice, and increased autonomy in patient care. The tutor provided essential support at critical moments. Most participants considered the activities fundamental to medical training and recommended them to peers, some developed interest in the field. There was an increase in the number of consultations and positive patient feedback. SIAT proved effective in practical teaching for PLWHIV care, fostering a collaborative environment that facilitates deep learning and development of relevant clinical skills. The integrative approach optimizes the teaching–learning process and aligns theory with practice in HIV/AIDS management. Identified logistical challenges require optimization to ensure model sustainability.Marcos de Assis Moura; Paulo César Apolinário de Souza; Sarah Moreira de Sousa Gomes; Cassiane Freitas Rodrigues

Work (physics); Computer science; Engineering ethics; Medical education; Psychology; Knowledge management

2026-03-01https://doi.org/10.1016/j.bjid.2026.105545The Brazilian Journal of Infectious Diseases 20261EVALUATION OF CIPROFLOXACIN RESISTANCE IN ESCHERICHIA COLI ISOLATED FROM URINE OF OUTPATIENTS WITH AND WITHOUT CHRONIC KIDNEY DISEASEIntroduction/Objectives Urinary tract infections are among the most common bacterial infections in clinical practice, with Escherichia coli as the main etiologic agent. Increasing antimicrobial resistance, especially to fluoroquinolones, represents a significant challenge in empirical management of these infections. Patients with chronic kidney disease (CKD) are particularly susceptible to infections and have greater prior exposure to antimicrobials, hospitalizations and comorbidities, factors that may favor the selection of resistant strains. In this context, it is essential to evaluate ciprofloxacin resistance profiles in E. coli isolated from urine of outpatients, comparing individuals with and without CKD, to guide appropriate therapy and contribute to bacterial resistance control strategies. Methods Cross-sectional study conducted through data collection from urine cultures of patients referred to a teaching hospital located in the Zona da Mata region of Minas Gerais. Urine culture results from 2024 were collected, and parameters analyzed included sex, age, microorganism isolated, resistance to ciprofloxacin and outpatient clinic of origin, which was divided into CKD clinic and general clinic (other medical specialties). This study was approved by the institutional research ethics committee. Results In 2024, 1,958 urine samples were submitted for culture, of which 21.4% (n=419) were positive for a microorganism, 10.3% (n=202) were considered mixed cultures and 68.3% (n=1,337) were negative. Among positive cultures, 78.8% were from female patients, and mean age was 56.3 years. E. coli was isolated in 48.4% (n=203), of which 25.12% (n=51) were resistant to ciprofloxacin. In the CKD clinic, 104 urine cultures were positive for bacteria; E. coli was isolated in 55.8% (n=58), and 44.8% (n=26) of these were resistant to ciprofloxacin. In the general clinic, among 315 positive cultures, E. coli accounted for 46% (n=145), of which 17.24% (n=25) were ciprofloxacin-resistant. Conclusion The data show a significantly higher rate of ciprofloxacin resistance in Escherichia coli isolated from patients with chronic kidney disease compared with patients from the general outpatient clinic. This finding reinforces the need for continuous surveillance of susceptibility profiles, especially in high-risk populations.Janita Soraia de Oliveira da Silva; Rafaela Gonçalves Ferreira; Natália Maria da Silva Fernandes.; Ronaldo Rodrigues da Costa; Luana Carvalho; Patrícia Guedes Garcia

Escherichia coli; Kidney disease; Ciprofloxacin; Urine; Kidney; Urinary system; Medicine; Internal medicine; Microbiology; Antibiotics; Antibiotic resistance; Enterobacteriaceae; Bacteria

2026-03-01https://doi.org/10.1016/j.bjid.2026.104989The Brazilian Journal of Infectious Diseases 20261ACUTE CHAGAS DISEASE IN A CHILD FROM THE INTERIOR OF MINAS GERAISChagas disease is a neglected tropical disease and constitutes an important public health problem in Latin America. Although the chronic form of the disease is the most prevalent, 1,271 cases of acute Chagas disease were confirmed in Brazil between 2021 and 2023. In this context, the present report describes a rare case of acute Chagas disease in a pediatric patient with atypical manifestations, initially investigated as a viral infection. A 2-year-and-4-month-old male patient, born and residing in a rural area of Mendes Pimentel, Minas Gerais, with no previous comorbidities, was admitted to a local emergency care service due to pallor for 15 days and an episode of syncope, without other complaints. He had an up-to-date vaccination history according to the National Immunization Program (PNI) and age-appropriate development. On physical examination, the patient was pale, anicteric, and acyanotic, with lymphadenomegaly in the submandibular, axillary, and inguinal regions measuring less than 2 cm, and a liver palpable 5 cm below the right costal margin. Initial laboratory investigation showed hemoglobin of 5 g/dL and hematocrit of 14.9%, leading to hospital admission for investigation of severe acute anemia and transfusional support, guided by a pediatric hematologist. Unexpectedly, the diagnosis of acute Chagas disease was established through direct visualization of the protozoan Trypanosoma sp. in a peripheral blood smear. Serologies for Epstein-Barr virus, cytomegalovirus, parvovirus B19, and toxoplasmosis were negative. The case was immediately reported, and the patient was treated with benznidazole at 10 mg/kg/day, twice daily, for 60 days, progressing to clinical and laboratory remission, with no complications after one year of treatment and outpatient follow-up with a pediatrician. The described case illustrates an uncommon presentation of acute Chagas disease in an immunocompetent pediatric patient, characterized by the absence of typical clinical signs of acute protozoan infection. Therefore, this report contributes to the recognition of possible variations in disease presentation during the acute phase, reinforcing the importance of maintaining Chagas disease among diagnostic possibilities even in atypical clinical scenarios, given that high clinical suspicion and epidemiological surveillance are fundamental for the control of neglected tropical diseases.Caio Souza Brandão; Patrícia Ferraz Martins; André Luiz Souza Gomes; Rinara Grossi Rocha de Andrade; Junea de Oliveira Garcia Ferrari

Chagas disease; Disease; Epidemiology; Incidence (geometry); Population; Medicine; Environmental health; Pediatrics

2026-03-01https://doi.org/10.1016/j.bjid.2026.105572The Brazilian Journal of Infectious Diseases 20261PULMONARY AND MENINGEAL CRYPTOCOCCOSIS IN AN IMMUNOCOMPETENT PATIENT: A CASE REPORTCryptococcosis is a systemic mycosis caused by Cryptococcus neoformans and Cryptococcus gattii and has worldwide distribution. Its occurrence in immunocompetent individuals is rare, which makes diagnosis challenging due to low suspicion and the diversity of clinical manifestations, and implies delays in treatment and worsening prognosis. This is a descriptive case report study conducted at a teaching hospital in the city of Juiz de Fora, Minas Gerais, aiming to describe an atypical case of cryptococcosis in an immunocompetent patient. The study describes the clinical course, laboratory and imaging findings, and treatment of an immunocompetent patient diagnosed with pulmonary and meningeal cryptococcosis who was hospitalized during April and May 2025 in this service. Information was obtained by reviewing the medical records. The study was conducted in accordance with ethical principles for research involving human beings. A 58-year-old male presented with pleuritic pain in the right hemithorax, night sweats, daily fever, and headache for 25 days. Chest CT revealed an expansive lesion involving the entire upper lobe of the right lung. Transthoracic biopsy of the lesion showed yeast-like structures suggestive of Cryptococcus sp. CSF examination revealed encapsulated yeast-like structures on India ink staining and growth of Cryptococcus sp. in culture. Treatment was carried out with liposomal amphotericin B and flucytosine at standard doses for 28 days, followed by fluconazole 800 mg/day. The patient evolved with worsening ventilatory pattern and dyspnea, as well as radiologic deterioration, and decortication and resection of the right upper lobe were indicated. Tissue and pleural fluid samples were collected for microbiological tests. India ink staining revealed encapsulated yeast-like structures, but no fungal growth was observed in culture. In the postoperative period, continuous suction drainage was used to aid lung re-expansion, and the patient developed nosocomial pneumonia on the 5th postoperative day. Late diagnosis of the disease may impact individual morbidity and mortality. Prospective studies are needed to observe the evolution of the disease in immunocompetent patients in order to support the development of therapeutic and diagnostic guidelines tailored to this population.Amanda Farão Lima Silva; Patrícia Guedes Garcia; Lucas Ribeiro de Andrade Nascimento; Cristiane Marcos Soares Dias Ferreira; Cassimiro Baesso Junior

Cryptococcosis; Meningitis; Mycosis; Disease; Immunocompetence; Medicine; Pathology

2026-03-01https://doi.org/10.1016/j.bjid.2026.105172The Brazilian Journal of Infectious Diseases 20261EPIDEMIOLOGICAL AND BACTERIOLOGICAL PROFILE OF PATIENTS AFFECTED BY HEALTHCARE-ASSOCIATED INFECTIONS IN INTENSIVE CARE UNITS OF A PUBLIC HOSPITAL IN SOUTHERN BAHIAHealthcare-associated infections (HAIs) are among the leading causes of morbidity and mortality worldwide, intensified by rising antimicrobial resistance, especially in intensive care units (ICUs). Southern Bahia lacks data on HAIs. The aim of this study was to characterize the epidemiological, clinical, and laboratory profile of patients diagnosed with HAIs caused by bacteria originating from ICUs in southern Bahia. This is a descriptive, observational study based on analysis of medical records and bacteriological reports of patients admitted to two ICUs of a public hospital located in southern Bahia, between May 2021 and April 2024, with laboratory diagnosis of central venous catheter-associated bloodstream infection (CLABSI), indwelling urinary catheter-associated urinary tract infection (CAUTI), and lower respiratory tract infection (LRTI) acquired in the ICUs. The sample consisted of data from 145 patients, collected after approval by the research ethics committee under CAAE number 74471523.6.0000.5526, approved on December 6, 2023. Culture data were used to determine the incidence of species and their antimicrobial resistance phenotypes. Analyses were performed using Stata 15.0 statistical software. Of the total patients, 33.1% came from units within the same hospital, 17.9% from external healthcare units, and 49% were admitted directly to the ICUs. Most were aged 18–59 years. The most prevalent comorbidity was arterial hypertension (40.7%). Twenty-one percent had a diagnosis of COVID-19. ICU mortality was 54.5%. A total of 159 HAIs were identified; the most frequent was LRTI (49.7%), followed by CLABSI (33.3%) and CAUTI (17%). Gram-negative bacteria were the most frequently isolated (88.4%), with high carbapenem resistance rates in Serratia marcescens (72.0%), Klebsiella pneumoniae (42.9%), and Acinetobacter baumannii/haemolyticus (86.7%). The latter showed 90.0% of isolates resistant to amikacin. Among Gram-positive bacteria, 57.1% of Staphylococcus aureus were methicillin-resistant (MRSA). The bacterial resistance profiles found demonstrate the need to improve infection control strategies and to rationalize antimicrobial use, aiming to reduce circulation of resistant isolates and improve patient care.Maria Clara Cardoso Salgado dos Santos; Lucas Miranda Marques; Danielle Souto de Medeiros; Talita Hevilyn Ramos da Cruz Almeida; Ana Paula Carvalho Mariano; Maisah Meyhr D’Carmo Sodré; Patrícia Guedes Garcia; Luana Carvalho

Epidemiology; Intensive care; Public hospital; Public health; Intensive care unit; Hospital care; Medicine; Emergency medicine; Intensive care medicine; Medical emergency; Incidence (geometry); Hospital admission

2026-03-01https://doi.org/10.1016/j.bjid.2026.105415The Brazilian Journal of Infectious Diseases 20261CHALLENGES FOR SWITCHING INTRAVENOUS TO ORAL ANTIMICROBIALS: PHYSICIAN INERTIA AS A BARRIER IN A BRAZILIAN HOSPITALThe timely switch from intravenous to oral administration is one of the key actions recommended by Antimicrobial Stewardship Programs. This practice offers several benefits, such as minimizing catheter-related adverse events, reducing treatment costs, and shortening hospital stays, without compromising treatment safety or efficacy. Despite this, up to two-thirds of eligible patients remain on intravenous therapy. Recognizing this scenario may help identify opportunities for improvement in clinical practice and support the implementation of standardized protocols. The objective of the study was to evaluate the frequency of prescriptions in which the route of administration was transitioned for ≥ 72 hours and that met the eligibility criteria. This was a cross-sectional study conducted from January 1 to May 31, 2025, in a teaching hospital located in the southern region of Brazil. Inclusion criteria were adult patients (≥ 18 years) hospitalized in critical and non-critical care units who received intravenous antimicrobials and were clinically eligible for conversion to oral therapy, that is, those with a clinical indication for sequential oral therapy according to institutional protocol. All patients receiving prophylactic antibiotic therapy were excluded. During the study period, six cases of antimicrobial route conversion were identified, five of which occurred in non-critical care units. The antimicrobial classes involved were quinolones, penicillins combined with beta-lactamase inhibitors, and macrolides. The findings reveal a low adherence to intravenous-to-oral antimicrobial conversion practices, even among patients hospitalized in non-critical units and receiving antimicrobials with good oral bioavailability. This scenario highlights the urgent need to implement structured strategies within the antimicrobial stewardship program, including tailored clinical protocols, staff training, and audit and feedback processes, to promote safe and effective adoption of conversion practices. Such measures may contribute to the improvement of key hospital indicators, including optimization of institutional resources and patient safety.Manuela Jacques; Marcelo Carneiro; André Milagres Pereira; Rochele Mosmann Menezes; Paula Trevisan; Ingrid Pilz; Felipe Provensi Rangel; Anna Júlia Castoldi Ravazio; Bruna Bombel da Luz; André Luiz Silva Alvim; Caroline Alegransi; Adália Pinheiro Loureiro; Alana Pinheiro Alves

Work (physics); MEDLINE; Inertia; Public health; Medicine; Medical emergency; Intensive care medicine; Emergency medicine

2026-03-01https://doi.org/10.1016/j.bjid.2026.104659The Brazilian Journal of Infectious Diseases 20261MOLECULAR CHARACTERIZATION OF CARBAPENEMASE CO-PRODUCTION IN KLEBSIELLA PNEUMONIAECarbapenem-resistant Klebsiella pneumoniae represents a serious public health threat due to its high prevalence and therapeutic difficulty. This resistance is often associated with the production of carbapenemases such as KPC, NDM, and OXA-48. The dissemination of these isolates in hospital environments requires continuous surveillance and strict infection control measures. In this context, this study aimed to investigate the prevalence and the genes encoding carbapenemases in carbapenem-resistant clinical isolates of K. pneumoniae from hospitalized patients, as well as to verify carbapenemase co-production in these isolates. This is a cross-sectional study conducted between 2020 and 2023 at a public hospital located in the Zona da Mata region of Minas Gerais, Brazil. Carbapenem-resistant K. pneumoniae strains obtained from clinical samples were analyzed. Initial species identification was performed by phenotypic methods and subsequently confirmed by mass spectrometry. Screening for carbapenem resistance was conducted by phenotypic tests, and detection of the resistance genes blaKPC , blaNDM , blaOXA-48 , blaIMP , and blaVIM was carried out by real-time polymerase chain reaction (qPCR). The study was approved by the Human Research Ethics Committee. A total of 67 carbapenem-resistant clinical isolates of K. pneumoniae were included, 30 from the years 2020 to 2022 and 37 from 2023. Molecular analysis revealed that 56.71% (n = 38) of isolates had only the blaKPC gene, while 10.44% (n = 7) expressed only the blaNDM gene. Co-production of blaKPC and blaNDM was identified in 31.35% (n = 21) of samples, and co-production of blaKPC and blaOXA-48 was detected in 1.5% (n = 1). It was observed that all co-production cases occurred in 2023, totaling 22 of the 37 isolates from that period, corresponding to 59.45% of the strains analyzed that year. The detection of K. pneumoniae with co-production of carbapenemase genes demonstrates the complexity of this species’ resistance profile and its clinical relevance in the dissemination of carbapenem resistance. These findings reinforce the need for more effective control strategies, the maintenance of microbiological surveillance programs, and the continuous development of studies to support targeted clinical interventions.Patrícia Guedes Garcia; Ana Clara de Lelis Araújo; Alessandra Figueiredo de Castro Nassar; Lívia Mara Silva; Luana Carvalho; Márcio Roberto Silva; Marcelo Silva Silvério; Olavo dos Santos Pereira Júnior; Romário Costa Fochat

Klebsiella pneumoniae; Bacteria; Escherichia coli; Antibiotics; Enterobacteriaceae; Isolation (microbiology); Klebsiella; Microbiology; Biology; Virology; Chemistry

2026-03-01https://doi.org/10.1016/j.bjid.2026.104650The Brazilian Journal of Infectious Diseases 20261HPV VACCINE COVERAGE IN ADOLESCENTS AND ITS RELATIONSHIP WITH PRIMARY HEALTH CARE IN BELÉM-PA IN THE YEARS 2021 TO 2023Human papillomavirus (HPV) infection is a serious public health problem and one of the main etiological agents of cervical cancer and other anogenital and oropharyngeal neoplasms. The HPV vaccine, provided free of charge by the Sistema Único de Saúde (SUS), is an effective preventive strategy. However, coverage remains uneven between sexes and across territories. To analyze HPV vaccination coverage in adolescents aged 9 to 14 years in the municipality of Belém, Pará, from 2021 to 2023, comparing it with Primary Health Care (PHC) coverage in the same period. Descriptive study with a quantitative approach, based on secondary data from the e-Gestor AB and Programa Nacional de Imunizações information systems of the Departamento de Informática do Sistema Único de Saúde (SI-PNI/Datasus). Information on PHC coverage in the municipality and percentages of quadrivalent HPV vaccination for boys and girls from 2021 to 2023 were collected. PHC coverage in Belém was 26.45% in 2021, 38.12% in 2022 and 31.70% in 2023, remaining below the minimum target of 70%. Vaccination coverage in girls was considerably higher than in boys in all years, reaching 71.20% (2021), 66.98% (2022) and 68.50% (2023). For boys, rates were significantly lower: 32.19% (2021), 32.28% (2022) and 42.14% (2023). It was also observed that changes in PHC coverage did not directly mirror variations in vaccination: despite PHC expansion in 2022, coverage remained stable for boys and slightly decreased for girls. In 2023, PHC coverage declined, but there was a significant increase in vaccination among boys, suggesting that immunization may be influenced by specific actions disconnected from primary care. This disconnection points to weaknesses in the articulation between PHC and vaccination strategies, particularly regarding active case-finding and outreach actions. Weak PHC in Belém hinders effective implementation of public policies that promote comprehensive and equitable immunization. The results reinforce the need for intersectoral actions, with stronger links between health and education, and specific campaigns targeting the vaccine-eligible population to expand equitable access to immunization and reduce existing vulnerabilities.Pâmela Karen Oliveira de Souza Pinho; Laís Gabriela da Silva Neves; Aline Maria Pereira Cruz Ramos; Cintia Yolette Urbano Pauxis Aben‐Athar; Glenda Roberta Oliveira Naiff Ferreira; Natália Maria Vieira Pereira Caldeira

Primary care; Primary health care; Health care; Human papillomavirus; Vaccination; MEDLINE; Medicine; Family medicine; Environmental health; Pediatrics; Population

2026-03-01https://doi.org/10.1016/j.bjid.2026.104947The Brazilian Journal of Infectious Diseases 20261EPIDEMIOLOGY OF CANDIDURIA AND ANTIFUNGAL SUSCEPTIBILITY PROFILE OF ISOLATES FROM RECENT YEARS IN A UNIVERSITY HOSPITAL IN MINAS GERAISIsolation of Candida spp. from urine samples (candiduria) is a common finding in hospitalized patients, especially those with risk factors such as intensive care unit admission, prior broad-spectrum antimicrobial therapy, and indwelling urinary catheters. Interpretation of candiduria relies on clinical and epidemiological data, as it may represent colonization or contamination, but can also indicate infection, other genitourinary pathologies, or even candidemia. This study aimed to retrospectively evaluate the epidemiological profile and antifungal susceptibility of isolates from hospitalized patients with candiduria in a university hospital in Minas Gerais. Yeasts isolated from urine samples of patients with candiduria between March 2021 and January 2023 were evaluated. Secondary data were collected from electronic medical records. Fungal identification was performed using phenotypic methods and MALDI-TOF MS, and isolates were subsequently subjected to commercially available antifungal susceptibility testing. Between 2021 and 2023, 106 yeast isolates were obtained from urine samples of 75 individuals. Most patients were elderly (66.7%), female (75%), hospitalized for prolonged periods in the ICU (41.3%), receiving antimicrobials (97.3%), and had indwelling urinary catheters (90.7%). The mortality rate was 38.7%. The most prevalent Candida species were C. albicans (42.5%), C. glabrata (27.4%), C. tropicalis (16.0%), C. parapsilosis (7.5%), and C. kefyr (2.8%). Antifungal susceptibility testing was performed using the disk diffusion method. The antifungals with the highest resistance rates were fluconazole (34.4%), voriconazole (31.2%), itraconazole (18.3%), and caspofungin (9.7%). C. glabrata showed the highest resistance profile. Proper interpretation of candiduria findings, identification of yeasts from clinical samples, and assessment of antifungal resistance provide valuable information on local epidemiology, guide clinical management, and support appropriate antifungal selection for the treatment of fungal infections.Laura Lavorato Soldati; Larissa Negrão Rebelo de Almeida; Maria de Lourdes Junqueira; Jane Cristina Diniz Correia; Laura Maria Andrade de Oliveira; Tatiana de Castro Abreu Pinto; Francis Moreira Borges; Priscila de Faria Pinto

University hospital; Epidemiology; Antifungal; Incidence (geometry); Regional hospital; Medicine; Environmental health; Internal medicine

2026-03-01https://doi.org/10.1016/j.bjid.2026.105186The Brazilian Journal of Infectious Diseases 20261HPV VACCINE COVERAGE IN ADOLESCENTS AND ITS RELATIONSHIP WITH PRIMARY HEALTH CARE IN BELÉM-PA IN THE YEARS 2021 TO 2023Introduction Human papillomavirus (HPV) infection is a serious public health problem and one of the main etiological agents of cervical cancer and other anogenital and oropharyngeal neoplasms. The HPV vaccine, provided free of charge by the Sistema Único de Saúde (SUS), is an effective preventive strategy. However, coverage remains uneven between sexes and across territories. Objective To analyze HPV vaccination coverage in adolescents aged 9 to 14 years in the municipality of Belém, Pará, from 2021 to 2023, comparing it with Primary Health Care (PHC) coverage in the same period. Method Descriptive study with a quantitative approach, based on secondary data from the e-Gestor AB and Programa Nacional de Imunizações information systems of the Departamento de Informática do Sistema Único de Saúde (SI-PNI/Datasus). Information on PHC coverage in the municipality and percentages of quadrivalent HPV vaccination for boys and girls from 2021 to 2023 were collected. Results PHC coverage in Belém was 26.45% in 2021, 38.12% in 2022 and 31.70% in 2023, remaining below the minimum target of 70%. Vaccination coverage in girls was considerably higher than in boys in all years, reaching 71.20% (2021), 66.98% (2022) and 68.50% (2023). For boys, rates were significantly lower: 32.19% (2021), 32.28% (2022) and 42.14% (2023). It was also observed that changes in PHC coverage did not directly mirror variations in vaccination: despite PHC expansion in 2022, coverage remained stable for boys and slightly decreased for girls. In 2023, PHC coverage declined, but there was a significant increase in vaccination among boys, suggesting that immunization may be influenced by specific actions disconnected from primary care. This disconnection points to weaknesses in the articulation between PHC and vaccination strategies, particularly regarding active case-finding and outreach actions. Conclusion Weak PHC in Belém hinders effective implementation of public policies that promote comprehensive and equitable immunization. The results reinforce the need for intersectoral actions, with stronger links between health and education, and specific campaigns targeting the vaccine-eligible population to expand equitable access to immunization and reduce existing vulnerabilities.Pâmela Karen Oliveira de Souza Pinho; Laís Gabriela da Silva Neves; Aline Maria Pereira Cruz Ramos; Cintia Yolette Urbano Pauxis Aben‐Athar; Glenda Roberta Oliveira Naiff Ferreira; Natália Maria Vieira Pereira Caldeira

Primary care; Primary health care; Health care; Human papillomavirus; Vaccination; MEDLINE; Medicine; Family medicine; Environmental health; Pediatrics; Population

2026-03-01https://doi.org/10.1016/j.bjid.2026.104931The Brazilian Journal of Infectious Diseases 20261HYDROALCOHOLIC EXTRACT OF PUNICA GRANATUM L. (POMEGRANATE) LEAF AND ITS ANTIMICROBIAL EFFECT AGAINST ORAL PATHOGENSIntroduction/Objectives Dental biofilm (DB) is a complex microbial structure associated with caries and periodontal disease, representing a major focus of oral microbiology research. Bacteria such as Streptococcus mutans and Streptococcus sobrinus are cariogenic due to their acid production, which promotes enamel demineralization. Preventing DB formation is challenging given its structural and microbial complexity, along with genetic and environmental factors. In this context, natural products have been investigated as alternatives to synthetic antimicrobials due to their lower toxicity, better biocompatibility, and reduced cost. Punica granatum (pomegranate) is known for its antimicrobial activity, attributed to phenolic compounds such as tannins and flavonoids. Although the fruit, seeds, and flowers have been studied, the leaves of P. granatum remain poorly explored. This study aimed to develop a hydroalcoholic extract from pomegranate leaves (HPE) and evaluate its antibacterial and antibiofilm activity against oral microorganisms. Methods P. granatum leaves were collected, macerated in 50% hydroalcoholic solution, and evaporated. The HPE was tested against bacterial and fungal strains relevant to dentistry using MIC and MBC tests according to CLSI (2022). Activity against S. mutans and S. sobrinus biofilms was evaluated through adhesion and disruption assays. Characterization was performed using Raman spectroscopy and AFM. Cytotoxicity was tested on J774A1 cells (MTT assay). Results The HPE showed significant antimicrobial activity, with MICs ranging from 0.39 to 6.25 µg/mL for bacteria and 1.56 µg/mL for yeasts. It demonstrated bactericidal activity against most strains. It inhibited S. sobrinus adhesion by up to 66.27% (2 × MIC) and showed biofilm-disrupting efficacy similar to azithromycin. The extract displayed low cytotoxicity and homogeneous structure, with viability higher than the control at all concentrations. Conclusion The HPE exhibited relevant antimicrobial and antibiofilm potential, with low toxicity and high efficacy against oral pathogens. Although the results are promising, further studies are needed to elucidate its mechanisms of action and validate its clinical application as a complementary therapy in dentistry.Luciana Cláudia Diniz Tavares; Mariana Simões; Bernardo Canedo; Ana Bárbara Polo; Ana Carolina Morais Apolônio

Punica; Antimicrobial; Medicinal plants; Antibiotics; Anti-Infective Agents; Traditional medicine; Biology; Medicine

2026-03-01https://doi.org/10.1016/j.bjid.2026.104667The Brazilian Journal of Infectious Diseases 20261EPIDEMIOLOGICAL PROFILE OF DEATHS AMONG BRAZILIANS DUE TO PARACOCCIDIOIDOMYCOSIS BETWEEN 2013 AND 2023Paracoccidioidomycosis is an endemic systemic mycosis and is among the ten leading causes of death from chronic and infectious diseases in Brazil. Its incidence ranges from 0.71 to 3.10 cases per 100,000 inhabitants per year in Brazil. In this context, this study aimed to analyze the epidemiological profile of deaths among Brazilians due to this disease between 2013 and 2023. Ecological study analyzing secondary data obtained from the Brazilian public health informatics platform (DATASUS), using the Mortality Information System (SIM). Data were included for paracoccidioidomycosis across Brazilian regions, considering the variables: sex, age group, ethnicity, and year of death from 2013 to 2023. Between 2013 and 2023, 774 deaths due to paracoccidioidomycosis were recorded in Brazil, distributed as follows: 105 in the North (13.5%), 367 in the Southeast (47.4%), 171 in the South (22.0%), 95 in the Central-West (12.2%), and 36 in the Northeast (4.6%). This indicates endemicity in the Southeast, which concentrated 47.4% (n = 367) of records. Regarding age group, there was predominance among individuals aged 50–59 years, with 226 deaths (29.2% of the total). Males were the most affected, accounting for 85.6% (n = 663) of confirmed cases. Regarding ethnicity, whites predominated with 51.0% (n = 395), followed by mixed race (“pardo”) with 35.1% (n = 272), Black with 10.3% (n = 80), Indigenous with 0.77% (n = 6), Asian with 0.38% (n = 3), and unknown with 2.3% (n = 18). In addition, the largest percentage increases in deaths were observed in almost all regions between 2018 and 2019 (15%) and between 2020 and 2021 (28%). These data reinforce that paracoccidioidomycosis is an important cause of mortality in Brazil, with endemicity in the Southeast and predominance among males, whites, and individuals aged 50–59 years. These findings indicate that prevention measures focused mainly on men and active screening in risk groups—considering both acute outbreaks and environmental exposure history—are essential. Understanding risk factors, exposure patterns, and immune response may help reduce disease burden, especially alongside improved reporting observed between 2020 and 2021.Debora Cristina da Silva Lourenço; ANA LUIZA MOREIRA DOS SANTOS; Monique de Souza Minhanele; Pâmella Carneiro da Cruz

Epidemiology; Paracoccidioidomycosis; Incidence (geometry); Disease; Population; Medicine; Environmental health

2026-03-01https://doi.org/10.1016/j.bjid.2026.105240The Brazilian Journal of Infectious Diseases 20261MICROBIAL ACTIVITY OF POMEGRANATE LEAF EXTRACT AGAINST RESISTANT STAPHYLOCOCCUS AUREUSBacterial resistance is a considerable public health risk, with projections of up to 10 million deaths per year by 2050. Resistant Staphylococcus aureus is one of the main multidrug-resistant hospital pathogens. Due to the low efficacy of many antimicrobials, there is growing interest in natural alternatives, such as pomegranate leaf extract ( Punica granatum ), which is rich in antimicrobial compounds such as punicalagin, ellagic acid, and tannins. To evaluate the antimicrobial activity of the hydroalcoholic extract of pomegranate leaf (HPE) against one sensitive strain ( S. aureus ATCC 33591) and nine resistant strains (ATCC 25904 and eight clinical strains – Ethics approval: CAAE 32572820.6.0000.5133). Leaves of P. granatum were collected, macerated in hydroalcoholic solution (50%), filtered, evaporated, and lyophilized. The eight clinical strains were tested for susceptibility with 18 antimicrobials. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) assays were performed using broth microdilution in Mueller-Hinton broth, with HPE concentrations ranging from 1000 to 7.8 μg/mL. Azithromycin (40 μg/mL) was used as a control. Inocula (5 × 10⁴ CFU/well) were prepared according to the 0.5 McFarland standard. Plates were incubated at 37°C for 24 h, and the MIC was defined as the lowest concentration visually inhibiting growth. For the MBC, 10 μL from wells without growth were plated on BHI agar. All tested strains were resistant (R) to benzylpenicillin and oxacillin, and most were resistant to clindamycin and erythromycin. Some showed intermediate susceptibility or resistance to rifampicin. Half of the strains were resistant to levofloxacin. Only one strain was resistant to trimethoprim/sulfamethoxazole, nitrofurantoin, and ciprofloxacin. HPE showed a mean MIC of 500 μg/mL with activity against four strains, including three resistant to at least one antimicrobial. It demonstrated microbiostatic action for four strains at the tested concentrations. The data indicate the promising potential of HPE as a microbiostatic agent against S. aureus , reinforcing the importance of investigating higher concentrations and the development of natural therapeutic formulations against resistant strains.Bernardo Canêdo Martins; Mariana Simões de Oliveira; Luciana Cláudia Diniz Tavares; Camila Pacheco Silveira Martins da Mata; Taleessa Vieira Gomes; Ana Carolina Morais Apolônio

Staphylococcus aureus; Bacteria; Antimicrobial; Antibacterial activity; Antibiotic resistance; Microorganism; Chemistry; Biology; Microbiology; Food science; Staphylococcus

2026-03-01https://doi.org/10.1016/j.bjid.2026.104640The Brazilian Journal of Infectious Diseases 20261AZITHROMYCIN AND TEA TREE OIL NANOCAPSULES COATED WITH CHITOSAN: A NEW STRATEGY AGAINST RESISTANT PATHOGENSThe problem of antimicrobial resistance has led to the study and development of new drug systems that combine natural compounds with classical antimicrobials. This study aimed to produce nanocapsules of Melaleuca alternifolia essential oil (TEO) and azithromycin (AZI) coated with chitosan (CH) with antimicrobial activity. The nanocapsule suspensions were prepared by the interfacial deposition method of a preformed polymer. They were then coated with CH solution at a 2% concentration. Physicochemical characterization included evaluation of pH, average hydrodynamic diameter (AHD), zeta potential (ZP), polydispersity index (PI), and morphological evaluation using Scanning Electron Microscopy (SEM). Biological tests performed included Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) of free AZI and encapsulated AZI against resistant microorganisms: Staphylococcus aureus ATCC 33591, Klebsiella pneumoniae ATCC BAA2814, Enterococcus faecalis ATCC 51299, and Streptococcus sobrinus ATCC 27531. The average AHD of the nanocapsule suspension before CH coating (206.2 ± 2.2 nm) at 2% was lower than after coating (238.5 ± 1.7 nm), suggesting the formation of a thin CH layer around the nanocapsules. The PI values (0.173 ± 0.005 before and 0.245 ± 0.010 after) show that the suspension maintained its homogeneity in particle size and distribution even after coating. The ZP, which was negative (–28.66 ± 1.40 mV), became positive (+28.06 ± 1.10 mV) after coating. The pH became more acidic (4.38) due to the presence of CH in the suspension. SEM images after CH coating revealed the spherical/oval shape of the nanocapsules. MIC values for encapsulated AZI were lower than those for the free form of the drug for all tested bacteria after 24 hours. The nanocapsules proved to be a promising approach to combat infections caused by the bacterial species tested.Mariana Simões de Oliveira; Vitória Batista Clemente; Michel de Oliveira Sales Júnior; Bernardo Canêdo Martins; Taleessa Vieira Gomes; Ana Carolina Morais Apolônio

Tea tree oil; Nanocapsules; Eucalyptus oil; Melaleuca alternifolia; Tree (set theory); Antibacterial agent; Chemistry; Food science; Bacteria; Antimicrobial

2026-03-01https://doi.org/10.1016/j.bjid.2026.104693The Brazilian Journal of Infectious Diseases 20261KNOWLEDGE ABOUT VACCINATION AND IMMUNIZATION AMONG MEDICAL INTERNS AT A FEDERAL UNIVERSITY IN GOVERNADOR VALADARESIntroduction/Objectives Since the creation of the National Immunization Program (PNI) in 1973, Brazil has achieved significant progress in the control and eradication of diseases. However, the growing trend of vaccine distrust in the country, also observed in other regions, has become a matter of substantial concern. Vaccination coverage has shown progressive declines since 2012, worsened in 2016 and intensified by the COVID-19 pandemic, which negatively affected vaccine uptake. Considering the role of medical schools in adequately training new professionals to discuss and intervene in this area, the present study aimed to assess the knowledge of medical interns at the Universidade Federal de Juiz de Fora, Governador Valadares campus, regarding immunizations. Methods Qualitative observational study in which data collection was carried out via an online questionnaire. The form contained 14 statements of varying levels of difficulty related to vaccination, with true or false answer options. Results were categorized according to the percentage of correct answers as unsatisfactory (up to 60%), regular (61%–80%), and satisfactory (above 80%). All participants agreed to participate by accepting the electronic Informed Consent Form. Results A total of 74 responses were obtained. Approximately 1.35% were classified as unsatisfactory, 72.9% as regular, and 25.6% as satisfactory. The statement with the highest error rate (33.8%) addressed vaccine contraindications in pregnant women, whereas the statements with the highest correct response rate (100%) addressed adverse events, the relationship between vaccines and autism, vaccine efficacy, and booster doses. Conclusion A certain degree of knowledge gap among students on this topic is evident. Despite the low percentage of unsatisfactory responses, there is clear potential for improvement in participants’ understanding of immunization. Within academic training, practices focused on immunization in infectious diseases courses, combined with addressing the topic in other curricular disciplines, represent a powerful tool for consolidating mastery of this thematic axis. In this way, it is possible to prepare future physicians to contribute to public policies and to health education efforts capable of reversing the downward trend in vaccination coverage.Laura Fernandes Franco; Patrícia Ferraz Martins; Julia Knupp Apolinário; Amanda Oliveira Andrade; André Luiz Souza Gomes; Caio Souza Brandão; Igor Soares Durães

Immunization; Vaccination; Public health; Government (linguistics); Medical school; Medicine; Family medicine; Medical education; Nursing

2026-03-01https://doi.org/10.1016/j.bjid.2026.105526The Brazilian Journal of Infectious Diseases 20261PROFILE OF INFLUENZA HOSPITALIZATIONS AND CORRELATION WITH VACCINATION COVERAGE IN BRAZIL: AN ECOLOGICAL STUDY FROM 2020 TO 2024Influenza is a viral respiratory infection with the potential to cause seasonal outbreaks and severe complications, especially in vulnerable groups such as older adults and children. The reduction in vaccination coverage rates in Brazil is a warning sign for the health system. This study aims to analyze the profile of hospitalizations due to Influenza between 2020 and 2024. Ecological, quantitative study based on secondary data from the TABNET/DATASUS platform. Information on Influenza was included for the different regions of Brazil, considering variables such as sex and age group (SINAN data), as well as the number of hospitalizations and deaths (SIH/SUS data) between 2020 and 2024. Vaccination coverage indicators from the Ministry of Health were also used. Descriptive statistics were applied using Excel for organizing the results. During the period analyzed, a total of 135,960 hospitalizations due to Influenza were observed in Brazil, with 66,924 (49.2%) patients male and 69,036 (50.7%) female. Among all cases, there were 7,013 deaths, corresponding to 5.1%. The region with the highest number of hospitalizations was the Northeast, with 59,788 (43.9%) notifications, and the Southeast showed the highest number of deaths regardless of age group, with 2,624 deaths, corresponding to 37.4% of all Influenza deaths from 2020 to 2024. The least affected region was the Center-West, with just over 9,000 cases and 576 deaths. Regarding age group, children aged 1 to 4 years and older adults aged 80 years or more were the most affected, with 20,966 and 16,934 hospitalizations, respectively. Despite being the second most prevalent age group, older adults aged 80 years or more accounted for the highest number of deaths (2,796). In addition, Influenza vaccination coverage in the older population has dropped drastically from 70.1% in 2021 to 40.45% in the North and 48.81% in the other regions of the country in 2024. According to Gonçalves et al. (2023), physiological changes, comorbidities and greater susceptibility to secondary infections make older adults more vulnerable to severe infectious conditions. Therefore, the relevance of annual Influenza vaccination, included in the Brazilian immunization schedule since 1999, is highlighted, especially in the autumn and winter, when incidence is higher.Debora Cristina da Silva Lourenço; Amanda Satomi Kimura Minami; ANA LUIZA MOREIRA DOS SANTOS; Gabriel Teixeira Guimarães da Fonseca; Giovanna Marino Fonseca; Monique de Souza Minhanele; Olivia Cacioli Tropeano; Pâmela Lorençoni de Moura; TAYNÁ AYARA DUTRA; Ana Lys Marques Feitosa

Ecological study; Vaccination; Correlation; Public health; Epidemiology; Influenza A virus; Environmental health; Medicine

2026-03-01https://doi.org/10.1016/j.bjid.2026.104964The Brazilian Journal of Infectious Diseases 20261ESOPHAGO-MEDIASTINAL FISTULA AS A COMPLICATION OF DISSEMINATED TUBERCULOSIS IN AN IMMUNOCOMPETENT PATIENT: A CASE REPORTTuberculosis is a public health issue that affects people worldwide and continues to burden developing countries, remaining one of the main causes of morbidity and mortality globally. This study reports a case of disseminated tuberculosis in an immunocompetent patient complicated by an esophago-mediastinal fistula. This descriptive, retrospective case report was based on medical record review and conducted in accordance with ethical principles for human research. The case involves a 24-year-old male with no comorbidities, admitted with a wasting syndrome, daily afternoon fever, and back pain. MRI showed an extensive paravertebral and iliopsoas collection associated with vertebral body erosions, suggestive of spondylodiscitis. Chest CT demonstrated bilateral upper-lobe nodular infiltrates that later evolved with cavitations. Without clinical improvement after antibiotics for common bacterial etiologies, preemptive anti-tuberculosis therapy was initiated, reinforced by a positive urinary TB antigen lateral flow test (LF-LAM) from an isolated urine sample. Paravertebral drainage by interventional radiology did not yield culture confirmation. Sputum AFB smear and Xpert MTB/RIF were negative. After treatment initiation, the patient improved clinically and laboratorially; however, subsequent CT revealed a fistulous tract between the mid-esophagus and posterior mediastinum with a mediastinal collection. Aspiration and drainage were performed, and molecular testing on the sample showed “trace” positivity for TB (“Xpert MTB/RIF trace”). With continued treatment and an alternative feeding route, the patient maintained progressive clinical and radiological improvement. This report describes an atypical presentation in an immunocompetent individual and a rare complication with few cases described in the literature. TB diagnosis and control remain challenging; in this context, LF-LAM, although not yet validated for this population, helped guide diagnosis and appropriate treatment.Lucas Ribeiro de Andrade Nascimento; Amanda Farão Lima Silva; Matheus Müller Martins; Cristiane Marcos Soares Dias Ferreira; Cassimiro Baesso Junior

Complication; Tuberculosis; Fistula; Disease; Mediastinitis; Medicine; Surgery

2026-03-01https://doi.org/10.1016/j.bjid.2026.105694The Brazilian Journal of Infectious Diseases 20261EPIDEMIOLOGICAL PROFILE OF MEASLES CASES AND CORRELATION WITH VACCINATION COVERAGE IN BRAZIL: AN ECOLOGICAL STUDY FROM 2014 TO 2024Measles is a highly contagious viral infectious disease associated with severe complications and preventable deaths. Considered eliminated in Brazil until 2018, it re-emerged due to declining vaccination coverage. This study aims to describe the epidemiological profile of measles in Brazil between 2014 and 2024, relating it to vaccination coverage in the period. Ecological, quantitative study based on secondary data from the TABNET/DATASUS platform. Measles notifications from SINAN and data on clinical outcomes and deaths from SIH/SUS between 2014 and 2024 were analyzed. Variables included sex, age group, race/skin color, outcome and geographic region. Vaccination data were obtained from SINAN up to 2022; for 2023 and 2024, information was extracted from the Ministry of Health platform. A total of 40,729 measles cases were notified in Brazil between 2014 and 2024. The regions with the highest incidence were: Southeast, concentrating 51.46% of records (n = 20,961), with the state of São Paulo accounting for 90.46% of these cases, and North, with 37.95% (n = 15,457), especially Amazonas (56.94%). The largest peaks occurred in 2019 (n = 21,661), 2018 (n = 9,333) and 2020 (n = 7,931), totaling 95.57% of notifications in the period. Most cases occurred in individuals self-declared pardo (mixed race) (43.94%) and white (40.40%), with a slight male predominance (54.03%). The most affected age groups were 20–29 years (28.91%) and children under 1 year (18.16%). The lowest incidence was observed in individuals aged 60 years or more, totaling only 141 cases. The cure rate was 90.13%, with 44 deaths attributed to the disease (0.10%), more than half in children under 1 year (52.27%; n = 23). In Brazil, between 2014 and 2024, the administration of the measles vaccine fluctuated considerably. The highest number of doses was recorded in 2024 (101,992,640), and the lowest in 2021 (173,303). The Southeast led with 41,680,144 doses, and the North had the lowest total (12,505,445). There was a decline between 2018 and 2021. Measles remains an obstacle for public health in Brazil, with higher incidence in the Southeast region. There was a predominance of cases in men, adults aged 20 to 29 years and people of mixed race. The increase in cases from 2018–2021 may be related to the drop in vaccination coverage during the COVID-19 pandemic. These data reinforce the importance of epidemiological surveillance and effective prevention strategies, such as expanding vaccination coverage.Debora Cristina da Silva Lourenço; Amanda Satomi Kimura Minami; ANA LUIZA MOREIRA DOS SANTOS; Gabriel Teixeira Guimarães da Fonseca; Giovanna Marino Fonseca; Monique de Souza Minhanele; Olivia Cacioli Tropeano; Pâmela Lorençoni de Moura; TAYNÁ AYARA DUTRA; Emanuela Lira Milhomem

Ecological study; Epidemiology; Measles; Vaccination; Correlation; Population; Environmental health; Medicine; Public health

2026-03-01https://doi.org/10.1016/j.bjid.2026.104965The Brazilian Journal of Infectious Diseases 20261INCREASE IN CASE NUMBERS AND MOST AFFECTED SOCIAL GROUPS: AN ECOLOGICAL STUDY OF TUBERCULOSIS IN BRAZILIntroduction Tuberculosis is a bacterial disease that leads to weight loss, night sweats, cough and fever, and can result in death. As a social disease, it requires public health attention to create policies directed at the most affected groups. Objectives To analyze trends in the number of tuberculosis cases between 2019 and 2023 in Brazil and the distribution of cases among social groups. Methodology Cross-sectional, ecological, retrospective and quantitative study using secondary data from DATASUS. Variables used were year of diagnosis, homelessness, incarceration, diabetes, alcoholism and smoking. Results Between 2019 and 2023, Brazil registered 487,010 cases of tuberculosis. Annual case counts were 96,685, 86,103, 91,264, 103,253 and 109,705, respectively. People experiencing homelessness accounted for 4.35% of total cases, representing 3.82% in 2019 and 5.21% in 2023. People incarcerated population accounted for 10.99% of cases (12.08% in 2019 and 10.08% in 2023). People with diabetes represented 8.62% of cases, with stable distribution. Individuals with alcoholism comprised 19.63% of cases (18.89% in 2019 and 21.02% in 2023). Smokers accounted for 25.77% of total cases (24.63% in 2019 and 28.21% in 2023). Discussion The decrease in tuberculosis cases in 2020 likely occurred due to underdiagnosis caused by the COVID-19 pandemic. The subsequent increase in disease through 2023 highlights the need for improved surveillance, early diagnosis and treatment of tuberculosis, especially in vulnerable groups. There was a proportional increase in cases among people experiencing homelessness, individuals with alcoholism and smokers, requiring greater attention for these groups. There was a proportional reduction in cases among the incarcerated population, but it is still necessary to address the unhealthy conditions and limited access to healthcare that facilitate tuberculosis transmission in prisons. People with diabetes still represent an important share of cases, although without proportional change over the years. Conclusion There was an increase in tuberculosis cases, demanding attention from public health sectors to achieve effective prevention, rapid diagnosis and effective treatment. Individuals with alcoholism, smokers and people experiencing homelessness should be targeted for specific public health strategies.S. Silva; Diogo Moisés; Maria Fernanda Rodrigues Fernandes; Rebeca Zandoná Pereira; Thais Araujo Infante Vieira; Amanda Schulze Dressler

Ecological study; Tuberculosis; Population; Social ecological model; Geography; Socioeconomics; Ecology; Environmental health

2026-03-01https://doi.org/10.1016/j.bjid.2026.104988The Brazilian Journal of Infectious Diseases 20261Spatial Structure Explains Morphological Variation Better Than Climatic Gradients in the South American Rattlesnake ( Crotalus durissus )ABSTRACT Morphological variation in vertebrates is often shaped by geographic and climatic factors, yet the applicability of broad‐scale ecogeographical rules remains debated, particularly in ectotherms. We investigated how climatic gradients and spatial structure influence body size in the South American rattlesnake ( Crotalus durissus ), a widely distributed species across diverse ecoregions. We analyzed morphometric data from 132 adult individuals, integrating 19 bioclimatic variables from WorldClim and geographic coordinates for each collection site. Body size variation was summarized using principal component analysis, and spatial autocorrelation was explicitly incorporated into the analytical framework. After accounting for spatial structure, climatic variables were not significant predictors of body size in either sex. Instead, males exhibited a latitudinal spatial trend, whereas females showed a structured southwestward decrease in size. These results indicate that spatial constraints and sex‐specific ecological pressures, rather than contemporary climatic gradients, shape morphological variation in C. durissus . Our findings highlight the importance of incorporating spatially explicit models when evaluating climate–trait relationships and contribute to a more nuanced understanding of morphological evolution in widespread ectothermic species.Mileny Otani; Henrique Caldeira Costa; Cláudio Henrique Zawadzki; Diego José Santana

Ectotherm; Variation (astronomy); Spatial ecology; Spatial variability; Geographic variation; Bergmann's rule; Principal component analysis; Spatial analysis; Ecology; Latitude; Macroecology; Geography; Biogeography; Physical geography; Allometry; Common spatial pattern; Climate change; Morphology (biology)

2026-03-01https://doi.org/10.1002/ece3.73298Ecology and Evolution 20261Cuidados de enfermagem no pré-natal: estratégias para a prevenção da violência obstétricaObjetivo: Identificar, na literatura científica, estratégias de cuidado de enfermagem no pré-natal que contribuem para a prevenção da violência obstétrica. Métodos: revisão integrativa da literatura realizada nas bases de dados Literatura Latino-Americana e do Caribe em Ciências da Saúde, Base de Dados de Enfermagem e Medical Literature Analysis and Retrieval System Online, no mês de março de 2025. Foram utilizados os descritores “Nursing Care”; “Prenatal Care”; “Obstetric Violence”, intermediados pelo operador boleano “AND” e “OR”. Resultados: A amostra foi constituída por dez artigos os quais evidenciaram, a partir de duas categorias analítica, "Percepções de mulheres sobre violência obstétrica: conhecimentos e vivências da assistência pré-natal e pós-parto" e "Violência obstétrica e práticas de cuidado: o papel do enfermeiro no cuidado à mulher", que práticas de cuidados humanizados no pré-natal, como acolhimento, escuta qualificada, educação em saúde e fortalecimento do vínculo profissional-gestante, contribuem para a redução de situações de violência obstétrica, além de promover autonomia e empoderamento das mulheres. Considerações finais: Conclui-se que a enfermagem desempenha papel central na promoção do cuidado humanizado durante o pré-natal, constituindo estratégia fundamental para prevenir a violência obstétrica. Destaca-se a necessidade de investimentos em capacitação profissional e políticas públicas voltadas para a humanização da assistência obstétrica.Ana Luiza Ferreira Farias; Mônica Maria Macieira; Bárbara Kellen Souza Oliveira; Miriane Andrade Moraes; Rosana Lopes Silva; Márcia Rosário Souza Guerra; Patrícia Crisóstomo da Silva; Fábio da Costa Carbogim; Luana Vieira Toledo; Franciane Silva Luiz

Nursing care; Work (physics); Autonomy; Medical care; Medicine; Humanities; Nursing

2026-03-15https://doi.org/10.25248/reas.e23194.2026Revista Eletrônica Acervo Saúde 20261Desastre em Juiz de Fora: o que o efeito das chuvas revela sobre o papel das Câmaras Municipais no BrasilGustavo Paravizo; Guilherme de Abreu Duque

Context (archaeology); Poison control; Population; Risk factor; Vulnerability (computing)

2026-03-16https://doi.org/10.64628/ade.9rjx66am7 20261New occurrences of Physarales (Amoebozoa, Myxomycetes) for the state of Minas Gerais, Southeastern BrazilABSTRACT (New occurrences of Physarales (Amoebozoa, Myxomycetes) for the state of Minas Gerais, Southeastern Brazil). Myxomycetes are organisms widely distributed around the globe, found in both hemispheres, and are of great importance for ecological processes such as nutrient cycling. The state of Minas Gerais has records of only 44 species of Myxomycetes, but there are still gaps regarding the distribution of these organisms. In this context, this paper presents the record of two new occurrences of Physarales for the state of Minas Gerais. The collections were made in the municipality of Belo Horizonte, during the X Brazilian Congress of Mycology. After analysis, two species were identified: Physarum bogoriense Racib and Physarum echinosporum Lister. Both represent new occurrences for state of Minas Gerais, increasing the number of species cited for the state from 44 to 46.Jorge Renato Pinheiro Velloso; Laise de Holanda Cavalcanti; Mateus Santana Ribeiro; Mateus Arduvino Reck; Athena Santos Nery; Clara Santos Rodrigues; Matheus Rodrigues Passos; Rodolfo Bizarria Jr; Fabricio Soares Moreira; Lucca de Araujo Toschi; Jair Putzke

State (computer science); Distribution (mathematics); Physarum; Global biodiversity; Biodiversity; Geography; Environmental protection; Ecology

2026-01-01https://doi.org/10.1590/2236-8906e482024Hoehnea 20261Mathematical Foundations of Spacetime Densification Theory: A Quantum Statistical Framework Linking Spaceon Microstructure to Emergent Gravity and Cosmic AccelerationThe unification of gravity with the quantum structure of spacetime remains one of the central challenges oftheoretical physics. In this work we develop the mathematical foundations of the Spacetime DensificationTheory (SDT), a framework in which gravity emerges from spatial variations in the density of fundamentaldiscrete spacetime excitations termed spaceons. In the macroscopic limit, the spaceon network isdescribed as a continuous scalar density field non-minimally coupled to curvature. By embedding theresulting action within the Horndeski scalar-tensor formalism, we demonstrate that the theory yieldsstrictly second-order field equations, ensuring classical stability and eliminating Ostrogradskyinstabilities. A conformal transformation to the Einstein frame allows the analytical derivation of thedensification force, an additional acceleration generated by gradients of the spaceon density field thatnaturally reproduces the phenomenology commonly attributed to dark matter in galactic systems.At the microscopic level, the spacetime vacuum is modeled as a quantum lattice gas of hard-core bosonicspaceons. Using the Grand Canonical Ensemble, we derive a universal equation of state governing thethermodynamic behavior of the spacetime substrate. This equation simultaneously accounts for twoextreme regimes of gravitational physics. In the low-density cosmological limit, the cohesive interaction ofthe spaceon field generates a negative pressure with effective equation-of-state parameter w ≈ -1,providing a first-principles origin for cosmic acceleration. In the high-density regime approaching thelattice saturation density, the excluded-volume packing pressure diverges, preventing gravitationalcollapse and replacing classical Schwarzschild singularities with regular de Sitter cores.The resulting framework establishes a direct connection between quantum statistical mechanics andgravitational dynamics. Once the homogeneous cosmological background is normalized to the observedcritical density, the cohesion parameter λ is fixed by the dark-energy density, and the theory naturallygenerates a characteristic acceleration scale of order cH0. Beyond reproducing standard cosmologicalbehavior, SDT predicts several potentially observable signatures, including weak chromatic gravitationallensing, mild scale dependence of the effective gravitational constant, and spacetime-inducedmodifications to galactic rotation curves. These features position SDT as a predictive and mathematicallyconsistent approach to emergent gravity, providing a novel bridge between effective field theory,spacetime microstructure, and cosmological observations.Paulo Giovanni de Albuquerque Suassuna

Spacetime; Quantum field theory in curved spacetime; Linearized gravity; Scalar field; General relativity; Semiclassical gravity; Gravitation; Quantum gravity; Background independence; Causal sets; Physics; Classical mechanics; Theoretical physics; Gravitational field; Spacetime topology; Quantum spacetime; Maxwell's equations in curved spacetime; Einstein field equations; Quantization (signal processing); Quantum field theory; Gravitational singularity; Spherically symmetric spacetime; Metric expansion of space

2026-03-16https://doi.org/10.5281/zenodo.19055094Zenodo (CERN European Organization for Nuclear Research) 20261DECOLONIZATION AND HUMAN MOBILITY IN CROSS-CULTURAL PSYCHOLOGYThis theoretical essay integrates critical perspectives on cross-cultural psychology, the concept of human mobility, and a policy implementation model to propose a renewed framework for professional practice. Starting from the recognition of cultural diversity as a fundamental reality (Matsumoto & Juang, 2004), the article examines criticisms of Western bias and "intellectual extractivism" in the field (Anjum & Aziz, 2024; Henrich et al., 2010). It is argued that adopting the term "mobility", rather than "migration", offers a more fluid and less charged lens for understanding human displacement and its psychological impacts (Cresswell, 2006). Next, Secchi's public policy model (Abad, 2017) is used as a framework to operationalize the implementation of the APA Multicultural Guidelines (2017), promoting epistemic justice and practical competence. It is concluded that a relevant and ethical cross-cultural psychology must be anti-colonial, sensitive to power and mobility dynamics, and committed to structured processes of institutional change.Alberto Abad; Luís Antônio Monteiro Campos; Ana Lucia Mendes Teixeira; Diogo Bonioli; Thelma Mary Araújo de Oliveira; José Carlos Tavares da Silva

Operationalization; Multiculturalism; Diversity (politics); Field (mathematics); Power (physics); Public policy; Economic Justice; Decolonization; Sociology; Epistemology; Engineering ethics; Social psychology; Psychology; Government (linguistics); Cultural diversity; Social justice

2026-03-16https://doi.org/10.18623/rvd.v23.5387Veredas do Direito Direito Ambiental e Desenvolvimento Sustentável 20261A Modular Non-Immersive VR Serious Game Framework for Telerehabilitation: Design and Proof-of-Concept Feasibility StudyThere is a growing need for accessible and engaging rehabilitation tools for individuals with neurodevelopmental disorders such as Cerebral palsy (CP), Down syndrome (DS), and Autism spectrum disorder (ASD). Serious games offer a promising approach, yet few are tailor-made to meet the therapeutic demands of these populations. A tailor-made, non-immersive virtual reality (VR) serious games framework featuring a basketball task was developed, with therapist-controlled modules for customization and monitoring. Twenty-eight participants (CP: 14; DS: 7; ASD: 7) completed the game across eight sessions, grouped into three practice phases: an initial session, an early adaptation phase, and a consolidated practice phase. Performance metrics included accuracy, reaction time, and number of victories. All groups improved performance across phases, with accuracy increasing significantly in central (p = 0.005) and total positions (p = 0.007). The number of victories also increased from the initial to the early adaptation phase (p = 0.019) and from the initial to the consolidated practice phase (p = 0.008). Participants with ASD showed significantly higher accuracy than the DS group, while CP and DS participants showed a temporary increase in reaction time during the early adaptation phase, followed by a reduction in the consolidated phase, suggesting task adaptation. These findings support the feasibility and short-term effectiveness of a modular, tailor-made serious games platform for telerehabilitation.Rodrigo Garcia Pontes; Eduardo Dati Dias; Julie H. Weingartner; Natalia Monteiro; Elisa J. Valenzuela; Renata Martins Rosa; Victoria Y. H. Silva; Íbis A. P. Moraes; Talita Dias da Silva-Magalhães; CN Monteiro; Luciano Vieira de Araújo

Serious game; Adaptation (eye); Modular design; Cerebral palsy; Task (project management); Virtual reality; Personalization; Autism spectrum disorder; Autism; Computer science; Psychology; Human–computer interaction; Rehabilitation; Video game; Applied psychology; Task analysis; Duration (music); Multimedia; Basketball; Virtual patient; Process management

2026-03-16https://doi.org/10.3390/computers15030192Computers 20261Spacetime Densification Theory: A Quantum Framework for Gravity and Its Cosmological Implications — A Human-AI Collaborative InvestigationThis research proposes a novel approach to one of the greatest challenges in theoretical physics: unifying quantum mechanics and gravity. The Spacetime Densification Theory (SDT) reconceptualizes gravity not as a curvature of a smooth spacetime continuum, but as the result of variations in the density of discrete quantum elements of spacetime—called spaceons. By doing so, it establishes a quantum-compatible framework for gravity that remains rooted in the familiar four-dimensional universe. The theory not only reproduces the well-tested predictions of General Relativity but also explains cosmological mysteries such as dark energy and dark matter as emergent properties of the quantum structure of spacetime—eliminating the need for exotic particles or fine-tuned constants. Moreover, it offers testable predictions, including frequency-dependent gravitational wave propagation and chromatic gravitational lensing, which could be probed by upcoming observational technologies. This work is also a case study in human-AI scientific collaboration, integrating human creativity with the analytical capabilities of advanced AI models like ChatGPT-4 and Claude 3.7. These tools assisted in theoretical exploration, literature synthesis, and visualization, all under rigorous human scientific oversight. Ultimately, this research presents a unified, elegant, and potentially testable model of gravity that may bridge the gap between Einstein's geometric theory and quantum physics—paving the way for a deeper understanding of the universe.Paulo Giovanni de Albuquerque Suassuna

Quantum gravity; Spacetime; General relativity; Dark energy; Gravitation; Quantum cosmology; Quantum field theory in curved spacetime; Quantum; Hořava–Lifshitz gravity; Loop quantum gravity; Theoretical physics; Physics; Classical mechanics; Quantum geometry; Fundamental interaction; Curvature; Semiclassical gravity; Quantum spacetime; Causal sets; Group field theory; Problem of time; Linearized gravity; Theory of relativity; Entropic gravity

2026-03-16https://doi.org/10.5281/zenodo.19055005Zenodo (CERN European Organization for Nuclear Research) 20261Power Flow-based Estimation of Short-Circuit Currents from Inverter-based ResourcesThis is the author's version of the work accepted for publication in IEEE Open Access Journal of Power and Energy (https://doi.org/10.1109/OAJPE.2026.3673646). From the previous version, this record adds: an overview of the control topology (figure 7), analyses of large systems, and a correction to the PPNR implementation that caused it to take significantly more time than needed to converge.Ramon Abritta; Gabriel Miguel Gomes Guerreiro; Pavlov Alexey; Tore Børresen Børre; Elisabetta Tedeschi; Sharma Apoorv Ranjan; Ivo Chaves da Silva Junior

Power (physics); Work (physics); Energy (signal processing); Control (management); Topology (electrical circuits); Estimation; Control theory (sociology); Current (fluid); Computer science; Reliability engineering

2026-03-12https://doi.org/10.5281/zenodo.19050567Zenodo (CERN European Organization for Nuclear Research) 20261Mathematical Foundations of Spacetime Densification Theory: A Quantum Statistical Framework Linking Spaceon Microstructure to Emergent Gravity and Cosmic AccelerationThe unification of gravity with the quantum structure of spacetime remains one of the central challenges oftheoretical physics. In this work we develop the mathematical foundations of the Spacetime DensificationTheory (SDT), a framework in which gravity emerges from spatial variations in the density of fundamentaldiscrete spacetime excitations termed spaceons. In the macroscopic limit, the spaceon network isdescribed as a continuous scalar density field non-minimally coupled to curvature. By embedding theresulting action within the Horndeski scalar-tensor formalism, we demonstrate that the theory yieldsstrictly second-order field equations, ensuring classical stability and eliminating Ostrogradskyinstabilities. A conformal transformation to the Einstein frame allows the analytical derivation of thedensification force, an additional acceleration generated by gradients of the spaceon density field thatnaturally reproduces the phenomenology commonly attributed to dark matter in galactic systems.At the microscopic level, the spacetime vacuum is modeled as a quantum lattice gas of hard-core bosonicspaceons. Using the Grand Canonical Ensemble, we derive a universal equation of state governing thethermodynamic behavior of the spacetime substrate. This equation simultaneously accounts for twoextreme regimes of gravitational physics. In the low-density cosmological limit, the cohesive interaction ofthe spaceon field generates a negative pressure with effective equation-of-state parameter w ≈ -1,providing a first-principles origin for cosmic acceleration. In the high-density regime approaching thelattice saturation density, the excluded-volume packing pressure diverges, preventing gravitationalcollapse and replacing classical Schwarzschild singularities with regular de Sitter cores.The resulting framework establishes a direct connection between quantum statistical mechanics andgravitational dynamics. Once the homogeneous cosmological background is normalized to the observedcritical density, the cohesion parameter λ is fixed by the dark-energy density, and the theory naturallygenerates a characteristic acceleration scale of order cH0. Beyond reproducing standard cosmologicalbehavior, SDT predicts several potentially observable signatures, including weak chromatic gravitationallensing, mild scale dependence of the effective gravitational constant, and spacetime-inducedmodifications to galactic rotation curves. These features position SDT as a predictive and mathematicallyconsistent approach to emergent gravity, providing a novel bridge between effective field theory,spacetime microstructure, and cosmological observations.Paulo Giovanni de Albuquerque Suassuna

2026-03-16https://doi.org/10.5281/zenodo.19055095Zenodo (CERN European Organization for Nuclear Research) 20261Análise comparativa de custos e desfechos entre apendicectomias laparotômicas e laparoscópicas no SUS entre 2014-2023Introdução: A apendicite é a principal emergência abdominal no Brasil e no mundo, tratada por apendicectomia, que pode ser realizada por laparotomia ou laparoscopia (minimamente invasiva). A laparotomia é um método tradicional eficaz, porém notou-se maior tempo de internação e risco de infecção. A laparoscopia, por outro lado, constatou recuperação mais rápida e menor taxa de infecção, embora implique maior custo e tempo cirúrgico. Objetivo: Analisar a evolução e realizar uma análise comparativa de custos e desfechos das duas abordagens no SUS entre 2014 e 2023. Material e Métodos: Pesquisa epidemiológica observacional do tipo ecológico, com abordagem de série temporal, baseada em dados do DATASUS. Resultados: Ao longo do período investigado, houve um aumento expressivo de 288,55% no número de apendicectomias laparoscópicas, enquanto a laparotomia apresentou redução de 1,47%. Os procedimentos laparoscópicos corresponderam a 7,2% do total gasto com apendicectomias no SUS, sendo o custo médio 9,05% superior ao da laparotomia. Observou-se menor mortalidade entre pacientes submetidos à laparoscopia, sendo 69,23% inferior à da abordagem aberta, sugerindo maior segurança do procedimento. O número absoluto de óbitos foi 57 vezes maior na laparotomia; contudo, a ausência de informações sobre a gravidade dos casos impede inferências causais, não sendo possível determinar se as diferenças refletem a técnica ou a seleção de pacientes mais graves. Conclusão: Este estudo revelou a crescente adoção da apendicectomia laparoscópica no SUS entre 2014 e 2023, evidenciando suas vantagens clínicas e econômicas. No entanto, desafios como custos iniciais e desigualdade regional ainda limitam sua implementação. Apesar do investimento elevado, os dados apontam para redução de complicações, tempo de internação e otimização de recursos hospitalares com a laparoscopia. Assim, os resultados indicam a importância da ampliação do acesso à laparoscopia no SUS de forma a aprimorar o atendimento e promover maior equidade no acesso a técnicas minimamente invasivas.Jacqueline Batista do Nascimento; Izadora Pala Toledo; Anaína Queiroz Palhares Correia; Fernanda Gabriele Pedroso Ecamila; Ricardo Naka Figueiredo; Newton Murillo Duarte de Avellar Netto

Production (economics); Context (archaeology); Government (linguistics); Medicine; Gynecology

2026-03-01https://doaj.org/article/d02687bb140c4b9fb9b3653b11106ae6DOAJ (DOAJ: Directory of Open Access Journals) 20261High-Performance Cardiac Electrophysiology: Performance and Scalability of GPU and MPI Open-Source SimulatorsLucas Marins Ramalho de Lima; Lucas Arantes Berg; Filipe De Lima Namorato; Fernando O. Campos; Rafael Sachetto; Marcelo Lobosco; Joventino de Oliveira Campos; Rodrigo Weber dos Santos

Scalability; Supercomputer; Benchmark (surveying); Context (archaeology); Acceleration; CUDA; Computational model; Graphics processing unit; Computer science; Parallel computing; Computer architecture; Computational science; Distributed computing; Key (lock); Computational complexity theory; Scale (ratio); General-purpose computing on graphics processing units; Cardiac electrophysiology

2026-01-01https://doi.org/10.2139/ssrn.6434221SSRN Electronic Journal 20261Análisis de la inclusión de la perspectiva de género en las instrucciones para los y las autoras y políticas editoriales de las revistas científicas de oncologíaEl estudio analiza la inclusión de la perspectiva de género en las políticas editoriales e instrucciones para autores/as de las 10 revistas de oncología más productivas con participación española (2011-2021). Los resultados revelan que sólo el 30% promueve lenguaje inclusivo, mientras que el 50% exige desagregar datos por sexo/género. Destacan Actas Urológicas Españolas, Annals of Oncology (Elsevier) y Cancers (MDPI) por integrar explícitamente directrices como las guías SAGER. Algunas revistas, como Blood (ASH) y Clinical and Translational Oncology (Springer), alinean sus políticas con el ICMJE. Solo MDPI y ASH Publications mencionan diversidad en comités editoriales, penalizando sesgos de género en la revisión por pares. A pesar de avances, persiste una baja adopción de estándares de género en oncología, lo que limita la calidad y equidad de la investigación. El estudio subraya la necesidad de políticas editoriales uniformes que fomenten análisis por sexo/género, lenguaje inclusivo y diversidad en autorías/comités, reduciendo sesgos que impactan en la atención oncológica. La implementación de herramientas como SAGER o el cuestionario HEIRES podría mejorar la representatividad y aplicabilidad clínica de los hallazgos.Cristina Rius; Telmo Ronzani; Rut Lucas-Domínguez

Annals; Spanish language; Context (archaeology); Middle Ages; Humanities; Art

2026-03-16https://doi.org/10.3145/vrc.10 20261Specialization in Distributed Photovoltaic Generation in the Legal Amazon: Determinants and Spatial StandardsJoão Pedro Barbosa; Fernando Salgueiro Perobelli; Gabriel Marcos Arcanjo; Denis Fernandes Alves; Rosa Livia Montenegro

Context (archaeology); Photovoltaic system; Index (typography); Electricity; Solar energy; Econometric model; Renewable energy; Spatial contextual awareness; Sustainable energy; Spatial econometrics; Economic geography; Business; Environmental economics; Economics; Industrial organization; Regional science; Sustainable development; Diffusion; Distributed generation; Incentive; Electricity generation; Probit model; Econometrics; Natural resource economics; Multivariate probit model; Energy (signal processing); Socioeconomic status; Estimation

2026-01-01https://doi.org/10.2139/ssrn.6430181SSRN Electronic Journal 20261Banco de Dados Epidemiológico: Prevalência de Enteroparasitoses e Fatores Socioambientais e de Higiene AssociadosEste conjunto de dados (dataset) contém informações epidemiológicas primárias e análises estatísticas tabuladas sobre a prevalência de infecções parasitárias intestinais (enteroparasitoses) e sua associação com variáveis sociodemográficos, fatores ambientais e hábitos de higiene. Os dados foram coletados a partir de questionários epidemiológicos e resultados de Exames Parasitológicos de Fezes (EPF), englobando indivíduos residentes em zonas urbanas e rurais, com predominância nas faixas etárias de 4 a 15 anos. O banco de dados permite a avaliação de risco de infecção por helmintos (ex: Schistosoma mansoni, Enterobius vermicularis, Ascaris lumbricoides) e protozoários (ex: Endolimax nana, Entamoeba coli, Giardia duodenalis). Estrutura dos Arquivos: BD completo.csv: Microdados contendo as variáveis demográficas (sexo, idade), sanitárias (fonte de água, destino de dejetos) e comportamentais (lavagem de mãos, hábito de andar calçado). Tabela 1.csv: Relação de helmintos e protozoários diagnosticados na amostra. Tabela 2.csv a Tabela 4.csv: Frequências absolutas e relativas de monoparasitismo, biparasitismo e poliparasitismo (associações parasitárias). Tabela 5.csv e Tabela 6.csv: Análises bivariadas (com valores de p) cruzando a positividade no EPF com variáveis sociodemográficas, infraestrutura sanitária e hábitos de higiene (destacando-se a significância estatística da ausência de calçados). Tabela 7.csv: Perfil epidemiológico estratificado dos indivíduos infectados por grupo de parasito. Este dataset é ideal para estudos retrospectivos, meta-análises em parasitologia clínica e modelagem preditiva em saúde pública e medicina tropical.GIRLEY ASSIS; M. C. G. Souza

Transmission (telecommunications); Data collection; Ascaris lumbricoides; Disease transmission; Geography; Humanities

2026-03-13https://doi.org/10.5281/zenodo.19065447Zenodo (CERN European Organization for Nuclear Research) 20261Validação da “História de Sofia”: tecnologia educativa para promoção do desenvolvimento de crianças nascidas prematurasObjetivo: validar o conteúdo e a aparência da tecnologia educativa “História de Sofia: batalhas e conquistas da família no cuidado e desenvolvimento da criança prematura”. Método: pesquisa metodológica quali-quantitativa. Coleta de dados por meio de grupo focal e questionário via web com juízes das áreas da saúde, educação e comunicação, e grupos focais com público alvo. Foi considerado o índice de validade de conteúdo (IVC) de 78%. Dados qualitativos foram submetidos à análise de conteúdo. Resultados: participaram 54 profissionais, 45 da área de saúde e 9 da área de comunicação e educação, e 16 cuidadores familiares. A tecnologia educativa foi validada por juízes da saúde com IVC de 100% em todos os quesitos, pelos juízes da educação e comunicação com IVC geral dos quesitos de 91,9%. Os cuidadores familiares consideraram a linguagem do material clara e acessível, refletindo sua experiência, e atendendo a uma lacuna na orientação sobre o desenvolvimento da criança nascida prematura; relataram interesse em utilizá-lo e compartilhá-lo com outras famílias. Conclusão: A tecnologia educativa foi considerada validada quanto ao conteúdo e à aparência, com potencial para apoiar famílias na promoção do desenvolvimento da criança nascida prematura, e subsidiar a prática dos profissionais que a acompanham.Rayla Amaral Lemos; Maria De Lá Ó Ramallo Veríssimo

Medical care; MEDLINE; Clinical Practice; Humanities; Philosophy

2026-02-13https://doi.org/10.11606/issn.2176-7262.rmrp.2025.225794Medicina (Ribeirão Preto) 20261Regularizing effect for a nonlocal maxwell–schrödinger systemAbstract In this paper we prove existence and regularity of weak solutions for the following system $$\begin{aligned} {\left\{ \begin{array}{ll} & -\text{ div }\Bigg (\bigg (\Vert \nabla u\Vert ^{p}_{L^{p}}+\Vert \nabla v\Vert ^{p}_{L^{p}}\bigg )|\nabla u|^{p-2}\nabla u\Bigg ) + g(x,u,v)=f \ \ \ \text{ in } \ \Omega ; \\ & -\text{ div }\Bigg (\bigg (\Vert \nabla u\Vert ^{p}_{L^{p}}+\Vert \nabla v\Vert ^{p}_{L^{p}}\bigg )|\nabla v|^{p-2}\nabla v\Bigg ) = h(x,u,v) \ \ \ \ \text{ in } \ \Omega ; \\ & u=v=0 \ \text{ on } \ \partial \Omega . \end{array}\right. } \end{aligned}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:mtable> <mml:mtr> <mml:mtd> <mml:mfenced> <mml:mrow> <mml:mtable> <mml:mtr> <mml:mtd/> <mml:mtd> <mml:mrow> <mml:mo>-</mml:mo> <mml:msubsup> <mml:mrow> <mml:mspace/> <mml:mtext>div</mml:mtext> <mml:mspace/> <mml:mrow> <mml:mo>(</mml:mo> </mml:mrow> <mml:mrow> <mml:mo>(</mml:mo> </mml:mrow> <mml:mo>‖</mml:mo> <mml:mi>∇</mml:mi> <mml:mi>u</mml:mi> <mml:mo>‖</mml:mo> </mml:mrow> <mml:msup> <mml:mi>L</mml:mi> <mml:mi>p</mml:mi> </mml:msup> <mml:mi>p</mml:mi> </mml:msubsup> <mml:mo>+</mml:mo> <mml:msubsup> <mml:mrow> <mml:mo>‖</mml:mo> <mml:mi>∇</mml:mi> <mml:mi>v</mml:mi> <mml:mo>‖</mml:mo> </mml:mrow> <mml:msup> <mml:mi>L</mml:mi> <mml:mi>p</mml:mi> </mml:msup> <mml:mi>p</mml:mi> </mml:msubsup> <mml:mrow> <mml:mo>)</mml:mo> </mml:mrow> <mml:msup> <mml:mrow> <mml:mo>|</mml:mo> <mml:mi>∇</mml:mi> <mml:mi>u</mml:mi> <mml:mo>|</mml:mo> </mml:mrow> <mml:mrow> <mml:mi>p</mml:mi> <mml:mo>-</mml:mo> <mml:mn>2</mml:mn> </mml:mrow> </mml:msup> <mml:mi>∇</mml:mi> <mml:mi>u</mml:mi> <mml:mrow> <mml:mo>)</mml:mo> </mml:mrow> <mml:mo>+</mml:mo> <mml:mi>g</mml:mi> <mml:mrow> <mml:mo>(</mml:mo> <mml:mi>x</mml:mi> <mml:mo>,</mml:mo> <mml:mi>u</mml:mi> <mml:mo>,</mml:mo> <mml:mi>v</mml:mi> <mml:mo>)</mml:mo> </mml:mrow> <mml:mo>=</mml:mo> <mml:mi>f</mml:mi> <mml:mspace/> <mml:mspace/> <mml:mspace/> <mml:mspace/> <mml:mtext>in</mml:mtext> <mml:mspace/> <mml:mspace/> <mml:mi>Ω</mml:mi> <mml:mo>;</mml:mo> </mml:mrow> </mml:mtd> </mml:mtr> <mml:mtr> <mml:mtd> <mml:mrow/> </mml:mtd> <mml:mtd> <mml:mrow> <mml:mo>-</mml:mo> <mml:msubsup> <mml:mrow> <mml:mspace/> <mml:mtext>div</mml:mtext> <mml:mspace/> <mml:mrow> <mml:mo>(</mml:mo> </mml:mrow> <mml:mrow> <mml:mo>(</mml:mo> </mml:mrow> <mml:mo>‖</mml:mo> <mml:mi>∇</mml:mi> <mml:mi>u</mml:mi> <mml:mo>‖</mml:mo> </mml:mrow> <mml:msup> <mml:mi>L</mml:mi> <mml:mi>p</mml:mi> </mml:msup> <mml:mi>p</mml:mi> </mml:msubsup> <mml:mo>+</mml:mo> <mml:msubsup> <mml:mrow> <mml:mo>‖</mml:mo> <mml:mi>∇</mml:mi> <mml:mi>v</mml:mi> <mml:mo>‖</mml:mo> </mml:mrow> <mml:msup> <mml:mi>L</mml:mi> <mml:mi>p</mml:mi> </mml:msup> <mml:mi>p</mml:mi> </mml:msubsup> <mml:mrow> <mml:mo>)</mml:mo> </mml:mrow> <mml:msup> <mml:mrow> <mml:mo>|</mml:mo> <mml:mi>∇</mml:mi> <mml:mi>v</mml:mi> <mml:mo>|</mml:mo>A. P. de Castro Santana; L. H. de Miranda

Stability (learning theory); Work (physics); Limit (mathematics); Operator (biology); Mathematics; Applied mathematics; Mathematical analysis; Physics

2026-03-17https://doi.org/10.1007/s00030-026-01212-4Nonlinear Differential Equations and Applications NoDEA 20261Maternal bovine appeasing substance analog mitigates the effects of excitable temperament on timed artificial insemination outcomes in Nellore cowsSamuel Rodrigues Bonamichi do Couto; Júlia Medeiros Cruz de Lima Martins; Felipe Zandonadi Brandão; Nicolas Moreira Piedras Monnerat Caparelli; Thiago Souza Vieira; João Paulo N. Andrade; Marco Roberto Bourg de Mello

Artificial insemination; Temperament; Insemination; Reproduction; Beef cattle; Biology; Andrology; Animal science; Medicine

2026-03-17https://doi.org/10.1016/j.anireprosci.2026.108170Animal Reproduction Science 20261Anosmia na Covid-19 e sua associação com doenças crônicas e outros sintomas de infecçõesBackground and Objectives: Anosmia in Covid-19 may indicate a more favorable prognosis, highlighting the importance of understanding associated factors to support clinical decisions. This study aimed to analyze the prevalence and factors related to anosmia in individuals tested for Covid-19. Methods: Data from a university extension program that provided molecular testing services for Covid-19 diagnosis were used. Data collected between April 2020 and January 2023 were used. The chi-square test (p<0.05) was used by grouping participants according to the molecular test result: positive and negative for Covid-19. Results: A total of 6.5% (n=2252) of the population had anosmia, of which 1228 tested positive for Covid-19. Most participants with anosmia were adult females. There was a significant association between Covid-19 anosmia and the variant change milestone in February 2021. Among chronic diseases in individuals with anosmia and Covid-19, there was a significant association (p<0.05) with high blood pressure and diabetes. Among the symptoms of individuals with anosmia and Covid-19, ageusia, headache, and cough were directly associated; while runny nose, sore throat, dyspnea, diarrhea, and vomiting were inversely associated (p<0.05). Conclusion: In this study, chronic diseases related to Covid-19 anosmia included high blood pressure and diabetes, and the associated symptoms were ageusia, headache, and cough. Runny nose, sore throat, dyspnea, diarrhea, and vomiting appeared less frequently than expected in individuals with anosmia and Covid-19.Fernanda Lopes Vilande; Terimar Facin Ruoso; Daniel Ângelo Sganzerla Graichen; Angela Giovana Batista

Anosmia; Vomiting; Population; Retching; Sore throat; Dysgeusia; Dysphagia; Medicine; Internal medicine; Pediatrics; Gynecology

2026-01-28https://doi.org/10.17058/reci.v15i4.19699Revista de Epidemiologia e Controle de Infecção 20261Banco de Dados Epidemiológico: Prevalência de Enteroparasitoses e Fatores Socioambientais e de Higiene AssociadosEste conjunto de dados (dataset) contém informações epidemiológicas primárias e análises estatísticas tabuladas sobre a prevalência de infecções parasitárias intestinais (enteroparasitoses) e sua associação com variáveis sociodemográficos, fatores ambientais e hábitos de higiene. Os dados foram coletados a partir de questionários epidemiológicos e resultados de Exames Parasitológicos de Fezes (EPF), englobando indivíduos residentes em zonas urbanas e rurais, com predominância nas faixas etárias de 4 a 15 anos. O banco de dados permite a avaliação de risco de infecção por helmintos (ex: Schistosoma mansoni, Enterobius vermicularis, Ascaris lumbricoides) e protozoários (ex: Endolimax nana, Entamoeba coli, Giardia duodenalis). Estrutura dos Arquivos: BD completo.csv: Microdados contendo as variáveis demográficas (sexo, idade), sanitárias (fonte de água, destino de dejetos) e comportamentais (lavagem de mãos, hábito de andar calçado). Tabela 1.csv: Relação de helmintos e protozoários diagnosticados na amostra. Tabela 2.csv a Tabela 4.csv: Frequências absolutas e relativas de monoparasitismo, biparasitismo e poliparasitismo (associações parasitárias). Tabela 5.csv e Tabela 6.csv: Análises bivariadas (com valores de p) cruzando a positividade no EPF com variáveis sociodemográficas, infraestrutura sanitária e hábitos de higiene (destacando-se a significância estatística da ausência de calçados). Tabela 7.csv: Perfil epidemiológico estratificado dos indivíduos infectados por grupo de parasito. Este dataset é ideal para estudos retrospectivos, meta-análises em parasitologia clínica e modelagem preditiva em saúde pública e medicina tropical.GIRLEY ASSIS; M. C. G. Souza

Transmission (telecommunications); Data collection; Ascaris lumbricoides; Disease transmission; Geography; Humanities

2026-03-13https://doi.org/10.5281/zenodo.19065446Zenodo (CERN European Organization for Nuclear Research) 20261Class-Based Adaptive Training for Facial Expression Recognition Using a Deep Convolutional NetworkBrian Maia; Lucas V. C. Santana; Gabriel Rezende da Silva; Mathews Edwirds Gomes Almeida; Paulo Rozatto; Luiz M. S. Maciel; Saulo Moraes Villela; Marcelo Vieira; Bruno Campos de Carvalho

Pattern recognition (psychology); Facial expression recognition; Convolutional neural network; Training (meteorology); Feature (linguistics); Deep learning; Computer science; Artificial intelligence; Speech recognition; Computer vision; Facial expression; Facial recognition system; Training set

2026-01-01https://doi.org/10.5220/0014338500004084 20261An integrative analysis of global patterns of methane (CH4) ebullition fluxes in inland waters : complete dataset [1974 - 2024][English] This dataset comprises qualitative data on 629 studies of methane (CH4) ebullition in inland waters spanning 1974 to 2024; 244 individual relationship outcomes between environmental variables and CH4 ebullition extracted from 64 studies, used in the meta-analysis of the regulation of CH4 ebullition in inland waters; and 814 data entries of CH4 ebullition fluxes from 228 studies collected through a systematic literature search following PRISMA guidelines, used in a quantitative analysis of global trends in ebullition fluxes in inland waters.Mariana Peifer Bezerra; Pedro Maia Barbosa; Paul A. del Giorgio

Methane; Trend analysis; Hydrology (agriculture); Methane emissions; Carbon flux; Environmental science; Physical geography; Global warming

2026-02-23https://doi.org/10.5683/sp3/z0hvllBorealis 20261Abordagem integral à saúde LGBTQIA+ e seus desafios em um município do sudoeste mineiroIntrodução: A Constituição Federal e os princípios do Sistema Único de Saúde (SUS) consolidam a saúde como direito de todos, mas pessoas LGBTQIA+ ainda encontram barreiras no acesso. O tratamento muitas vezes discriminatório e heteronormativo acentua essa vulnerabilidade. As demandas dessa população são frequentemente restritas a Infecções Sexualmente Transmissíveis (ISTs), evidenciando despreparo profissional e a necessidade de um atendimento integral. Objetivo: Descrever as etapas e analisar os resultados encontrados sobre o projeto de pesquisa “Caracterização da assistência em saúde à população LGBTQIA+ em um município do sudoeste mineiro”, realizado na Universidade do Estado de Minas Gerais (UEMG), em Passos/MG. Métodos: Trata-se de um estudo quantitativo, transversal, exploratório, descritivo e analítico realizado em 22 unidades de Atenção Primária à Saúde (APS) em Passos/MG, entre setembro e novembro de 2022. A pesquisa incluiu 136 profissionais da Estratégia Saúde da Família (ESF). A coleta de dados seguiu um cronograma definido após a aprovação pelo Comitê de Ética em Pesquisa da UEMG e foi realizada por meio de dois questionários autopreenchidos: um sociodemográfico e outro sobre a percepção e o conhecimento dos profissionais em relação à saúde LGBTQIA+. O instrumento foi refinado por oito especialistas, que sugeriram ajustes nas perguntas para garantir maior adequação. As respostas foram tabuladas e analisadas no software SPSS. Resultados: Dos profissionais entrevistados, 80,1% relataram que não se lembram ou não receberam capacitação sobre saúde LGBTQIA+; 28,7% avaliaram seu conhecimento sobre a Política Nacional de Saúde Integral de Lésbicas, Gays, Bissexuais, Transexuais, Travestis e Transgêneros (PNSI-LGBT) como “bom”, enquanto 70,5% classificaram como “mediano” ou “ruim”. Ainda assim, 56,6% acreditam que suas equipes estão aptas para atender essa população. No entanto, a discrepância entre o baixo nível de capacitação e a percepção de aptidão para o atendimento revela uma lacuna significativa na formação profissional. A maioria dos participantes (75,7%) concorda que a inclusão de conteúdos sobre diversidade sexual e de gênero nos currículos de formação é essencial, em contraste com os 8,1% que não veem relevância. A maioria dos profissionais reconhece a sexualidade como determinante em saúde (77,2%). Conclusões: Os resultados, embora limitados em função da amostra e região, trazem dados que vão ao encontro da literatura: há uma defasagem e um despreparo profissional. Recomenda-se a implementação de capacitações regulares e a criação de estratégias que reforcem políticas públicas inclusivas. A adoção dessas práticas pode contribuir para melhorar o cuidado integral e reduzir as iniquidades no acesso à saúde.Sthefany de Paula Gomes; Danielle Fernanda Evangelista Silva; Luciana dos Santos Prates; Thaís de Melo do Nascimento Brunharo; Policardo Gonçalves da Silva

Work (physics); Data collection; Order (exchange); Context (archaeology); Humanities; Political science

2026-03-18https://doi.org/10.5712/rbmfc21(48)3621Revista Brasileira de Medicina de Família e Comunidade 20261The Big Team-Up: How a Giant Microbe Helps the Capybara’s DigestionThe capybara, the world’s largest rodent, weighs up to 90 kg and measures over one meter in length. Capybaras feed on grasses, fruits, and tree bark. However, these plants are coated in tough cellulose, which is difficult to digest. To overcome this, the capybara relies on microbes in its gut that help break down the cellulose and release nutrients. One key microbe is Muni , a giant protozoan that can grow to be up to 3 mm long, visible to the naked eye. Scientists have discovered that Muni has genes that produce powerful enzymes essential for the capybara’s digestion. This remarkable partnership between the capybara and its microbial allies highlights how cooperation can help overcome life’s toughest challenges.Franciane Cedrola; Marcus Vinicius Xavier Senra; Millke Jasmine Arminini Morales; Priscila Fregulia; Lucas Eduardo Costa Canesin; Roberto Júnio Pedroso Dias; Vera Nisaka Solferini

Digestion (alchemy); Cellulose; Key (lock); Bacterial cellulose; Tree (set theory); Biology; Food science; Chemistry

2026-03-18https://doi.org/10.3389/frym.2026.1483371Frontiers for Young Minds 20261Differential Effects of DHA-Rich Fish Oil Supplementation on Intestinal and Pulmonary Alterations in Experimental Malaria Caused by Plasmodium berghei NK65High Resolution Image Download MS PowerPoint Slide Malaria infection can trigger Acute Respiratory Distress Syndrome (ARDS), a potentially lethal complication resulting, among other factors, from an exacerbated inflammatory response associated with the infection. In addition, the disease appears to impact the intestinal tract, causing disorders that in turn can influence the severity of lung damage due to bidirectional communication between these organs, known as the gut-lung axis. DHA-rich fish oil (omega-3) has been demonstrated to mitigate lung inflammation in mice infected with Plasmodium berghei ANKA, a highly virulent parasite strain. However, it remains unclear whether this effect extends to any species or strain of Plasmodium . Therefore, in this study, the potential of DHA-rich fish oil to modulate lung injury was evaluated during the experimental infection of C57BL/6 mice infected with P. berghei NK65. In addition, we also analyzed the effect of supplementation on the intestinal environment. Although DHA-rich fish oil supplementation was associated with partial preservation of intestinal morphology, including reduced intestinal shortening, these effects did not translate into improved pulmonary outcomes. These findings highlight the strain- and pathogenesis-dependent effects of ω-3 supplementation, emphasizing distinct responses across different infection models. Specifically, our results reinforce the importance of considering the diversity of pathogenic profiles among Plasmodium strains in the investigation of nutritional or immunomodulatory interventions.Ludmila Ponce Monken Custódio Pereira; José Henrique Silva-Rodrigues; Fernanda Martins Pinheiro; Letícia Ferreira Machado; Ana Carolina Fonseca da Silva; Carolina Brandi Marques; Milena Tavares Gomes; Fernanda Mikaela Moreira Gonçalves; Jéssica Correia Bezerra-Bellei; Gabriel Brum; Vanessa Cordeiro Dias; João Renato Hipólito; André Netto Bastos; Haroldo Lobo dos Santos Nascimento; Flávia Marcia de Castro e Silva; Heloísa D’Ávila; A. Hallack Neto; Janildo Ludolf Reis; Vinícius Novaes Rocha; Flávia Lima Ribeiro-Gomes; Juciane Maria de Andrade Castro; Kézia Katiani Gorza Scopel

Differential effects; Malaria; Fish oil; Fish <Actinopterygii>; Animal model; Immune system; Biology; Medicine; Physiology; Immunology; Internal medicine; Pharmacology; Endocrinology

2026-03-20https://doi.org/10.1021/acsomega.5c12964ACS Omega 20261Factors associated with the social participation of individuals hospitalized with HIV/AIDSAbstract Introduction: HIV/AIDS imposes both physical and mental burdens that may hinder the social participation of affected individuals. Understanding the factors associated with social participation in this population enables the development of effective preventive and rehabilitative strategies. Objective: To assess social participation among people living with HIV/AIDS who were hospitalized and to examine whether demographic, clinical, psychological, and functionality-related characteristics are associated with their social participation. Methods: This was a cross-sectional study evaluating individuals diagnosed with HIV/AIDS upon hospital admission. The following aspects were assessed: clinical characteristics (time since diagnosis and CD4+ T-cell count), demographic data (age, physical activity level), social participation (LIFE-HABITS 3.1), cognitive function (Mini-Mental State Examination), psychological status (Hospital Anxiety and Depression Scale), handgrip strength (Handgrip Test), respiratory muscle strength (manovacuometry), and postural balance (Mini-BESTest). Pearson or Spearman correlation tests were used (p < 0.05). Results: Ten participants were included (90% female; mean age 42.3 years). Significant restrictions in social participation were observed in the domains of recreation and education. Additionally, respiratory muscle strength was associated (p < 0.05) with the mobility subdomain (R = 0.68); cognitive function was associated with the responsibilities subdomain and total score (R = 0.62 and R = 0.63, respectively); anxiety was negatively associated with the employment subdomain (R = −0.73); and age was negatively associated with the employment subdomain (R = −0.65). Conclusion: Social participation was found to be restricted in this population, and factors such as cognitive impairment, increased anxiety, and decreased inspiratory muscle strength were associated with lower levels of social participation.Roberta de Araújo Silva; Pedro Nicolato Alves; Daniel Godoy Martinêz; Carla Malaguti; Leonardo Barbosa de Almeida

Anxiety; Social engagement; Cognition; Population; Depression (economics); Recreation; Social support; Psychology; Gerontology; Muscle strength; Clinical psychology; Medicine; Balance (ability); Physical therapy; Community participation; Mental health

2026-01-01https://doi.org/10.1590/fm.2026.39101Fisioterapia em Movimento 20261Cotton fabrics functionalized with hydroxyl-rich graphene derivatives and silver nanowires: washing resistance and preliminary antibacterial activity against Escherichia coliAbstract Cotton-based antimicrobial textiles are attractive for applications requiring improved microbiological control, but their performance depends on effective surface functionalization and retention of the active materials after use and washing. In this work, cotton fabrics were functionalized with hydroxyl-rich graphene oxide (HGO), hydroxyl-rich reduced graphene oxide (H-rGO), and silver nanowires (AgNWs), either individually or in combined treatments, to investigate their deposition onto the textile surface, washing resistance, and preliminary antibacterial activity. The treated fabrics were prepared by immersion-based coating procedures, and the persistence of the deposited materials after repeated washing was evaluated by UV-Vis analysis of the residual wash solutions. Surface morphology before and after washing was examined by scanning electron microscopy. The results showed that graphene-based coatings, particularly HGO, exhibited stronger retention on cotton fibers, while AgNWs were partially retained after repeated washing cycles. SEM images confirmed the deposition of AgNWs on the cotton surface and showed that part of the coating remained associated with the fibers after washing. A preliminary antibacterial assay against Escherichia coli indicated that nanomaterial-treated fabrics inhibited bacterial growth relative to untreated controls, with the combined HGO/AgNWs treatment showing the most promising inhibitory trend under the tested conditions. These findings demonstrate the feasibility of producing cotton fabrics functionalized with hydroxyl-rich graphene derivatives and silver nanowires, supporting their potential as proof-of-concept antibacterial textiles with partial washing resistance.A. H. Lima; D.B.R. Silva; G. R. Carvalho; A. C. P. Fernandes; C. T. Tavares; N. C. Vicentini; C. C. S. Cunha; R. A. Dias; Alessandro Del’Duca; D. E. Cesar; A. S. A. Watanabe; W. G. Quirino

Graphene; Antibacterial activity; Coating; Surface modification; Textile; Antimicrobial; Scanning electron microscope; Materials science; Oxide; Chemical engineering; Chemistry; Nuclear chemistry; Antibacterial agent; Deposition (geology); Bacterial growth; Composite material

2026-03-17https://doi.org/10.64898/2026.03.16.710677bioRxiv (Cold Spring Harbor Laboratory) 20261O Acervo Musical do Colégio Santa Catarina em Juiz de ForaAssim como poucas expressões humanas, a música se mostra como registro evidente de transformações históricas, políticas e culturais. No caso do Colégio Santa Catarina de Juiz de Fora, uma instituição de origem alemã, a presença da música e de suas mudanças – desde a fundação aos dias atuais, transparece no estudo de seu acervo. Através da música, se deixam notar eventos históricos significativos, como a Segunda Guerra Mundial, o nacionalismo brasileiro, o fortalecimento da indústria e do capitalismo, que por sua vez se traduzem em elementos musicais próprios, como o ensino da música erudita ocidental, sobretudo do piano, a prática do Canto Orfeônico e mais recentemente a aplicação de métodos ativos em música, como o Suzuki. O presente artigo relata tal processo através de um extenso levantamento bibliográfico e histórico, além da listagem de fontes musicais presentes na biblioteca do colégio e de entrevistas exclusivas. As transformações históricas, assim como a necessidade de adaptação ao cenário brasileiro, constituíram um progressivo distanciamento do idioma alemão, o que também se observa em relação ao repertório musical, no entanto, e ainda que muitas práticas musicais tenham se perdido, observam-se presentes valores praticados desde a fundação do Colégio e, dentre eles, destaca-se a valorização indubitável da prática musical.Letícia Almeida Carlos; Marta Castello Branco

Musical; Power (physics); Quality (philosophy); Vanguard; Art; Humanities

2026-03-17https://doi.org/10.5216/mh.v26.83875Música Hodie 20261Throughput-Aware Two-Stage User Grouping and Scheduling Based on Genetic Algorithm for NOMA in Industrial Wireless NetworksUltra-reliable low-latency communication (URLLC) has become an integral part of modern industrial wireless networks (IWNs) with rapidly growing number of interconnected sensors. Owing to its notable benefits, nonorthogonal multiple access (NOMA) has become a great choice for IWNs. To enhance resource utilization, user grouping in NOMA systems has been investigated in recent years, focusing on power allocation and sum-rate optimization. This article goes beyond state-of-the-art and proposes a novel user grouping and scheduling algorithm for a hybrid NOMA–OFDMA system tailored to URLLC in IWNs by considering the effective throughput of individual users as a function of bit error rate. First, we formulate an optimization problem to maximize the sum rate while ensuring that the channel gains of the grouped users are sufficiently different and users with similar throughput requirements are grouped together. We propose novel usage of one-stage and two-stage genetic algorithm to find the optimal solution to the user grouping problem in uplink IWN. Scheduling users to physical resource blocks is solved as a bin packing problem. The proposed algorithm is rigorously evaluated based on effective throughput and user fairness. Our findings conclusively demonstrate that the framework not only satisfies the individual throughput demands of each user but also significantly reduces latency compared to the existing order-based grouping and OFDMA. In addition, a notable outcome of the proposed approach is a marked improvement in user fairness, ensuring a more balanced and equitable distribution of network resources among users, which is a critical aspect of enhancing overall network performance.Tabinda Ashraf; Sean McSweeny; Álvaro A. M. De Medeiros; Victor Cionca

Scheduling (production processes); Telecommunications link; Latency (audio); Wireless; Wireless network; Throughput; Noma; User equipment; Genetic algorithm; Computer science; Computer network; Distributed computing; Maximum throughput scheduling; Multi-user; Channel (broadcasting); Fair-share scheduling; Optimization problem; Proportionally fair; User requirements document; Algorithm design; Resource management (computing); Resource allocation

2026-03-18https://doi.org/10.1109/tii.2026.3666109IEEE Transactions on Industrial Informatics 20261Upgrade of the Trigger and Data Acquisition System for Continuous Imaging and Multi-Camera Operation in CYGNOThe CYGNO experiment employs an optical readout to image particle interactions in a gaseous Time Projection Chamber (TPC), combining cameras and photomultiplier tubes (PMTs) to achieve high spatial resolution and timing information. This approach enables detailed track reconstruction but poses significant challenges for data acquisition, particularly in view of the next experimental phase, CYGNO-04, which will operate multiple cameras simultaneously. In this paper, we present an upgrade of the CYGNO Trigger and Data Acquisition (T-DAQ) system, developed starting from the LIME configuration and validated on the MANGO prototype. The upgrade introduces a continuous imaging acquisition mode, substantially reducing the camera dead time, together with an extended trigger time-tagging scheme that provides a robust global time reference for PMT signals. A synchronous multi-camera DAQ architecture is also implemented and tested, enabling coordinated operation of multiple optical sensors without a master camera. The performance of the upgraded system is validated through dedicated tests, demonstrating stable continuous acquisition, reliable time-tagging, and consistent synchronization across multiple cameras. These results establish a solid and scalable foundation for the CYGNO-04 DAQ and represent a key step toward efficient data acquisition in future large-scale optical TPC detectors.F. D. Amaro; R. Antonietti; E. Baracchini; L. Benussi; C. Capoccia; M. Caponero; L. G. M. de Carvalho; G. Cavoto; I. A. Costa; Antonio Croce; M. D'Astolfo; G. D'Imperio; G. Dho; E. Di Marco; J. M. F. dos Santos; D. Fiorina; F. Iacoangeli; Z. Islam; E. Kemp; H. P. Lima; G. Maccarrone; R. D. P. Mano; D. J. G. Marques; G. Mazzitelli; P. Meloni; A. Messina; V. Monno; C. M. B. Monteiro; R. A. Nobrega; G. M. Oppedisano; I. F. Pains; E. Paoletti; F. Petrucci; Stefano Piacentini; D. Pierluigi; D. Pinci; F. Renga; A. Russo; G. Saviano; P. A. O. C. Silva; N. J. Spooner; R. Tesauro; S. Tomassini; D Tozzi

Data acquisition; Upgrade; Scalability; Synchronization (alternating current); Projection (relational algebra); Image resolution; Continuous monitoring; Key (lock); Computer hardware; Computer science; Real-time computing; Image sensor; Temporal resolution; Photomultiplier; Tracking (education); Instrumentation (computer programming)

2026-03-16https://doi.org/10.48550/arxiv.2603.15878arXiv (Cornell University) 20261Life After Retirement, “Re-firement,” Un-retirement, and Pre-retirement: Experiences of Four PsychiatristsFor health care professionals, especially psychiatrists, retirement is not a narrowly defined process. Retirement only means the end of a specific work-related job. It is closely related to aging although the impact of aging on the body and mind varies. In recent decades, there has been growing focus on healthy aging, which is associated with continued professional activity. This article summarizes retirement-related personal experiences described by four psychiatrists who are clinicians and academicians from diverse backgrounds. Three of us have technically retired from our previously titled specific jobs, but all remain markedly active as psychiatrists. Each has a sense of purpose, continues to be productive, and maintains close, positive connections with colleagues and community. The fourth and youngest of us is at least a decade away from retirement and plans to continue life's thrilling journey delightedly. Our experiences exemplify how retirement does not require a health care professional to abandon other vital aspects of their lifelong professional activity and identity, such as learning, helping, serving, caring, reading, writing, teaching, discussing, and understanding. Psychodynamic and positive orientations in particular lead to a strong belief in the need to be an active and compassionate member of the community who helps promote one's own as well as others' well-being. The so-called retirement provides a psychiatrist with the opportunity to ponder, deepen, and savor the adventure of living within the context of an exceptionally broad range of experience with the human condition.H. Steven Moffic; Harold Kudler; Alexander Moreira-Almeida; Dilip V. Jeste

Adventure; Context (archaeology); Psychodynamics; Health professionals; Health care; Retirement community; Psychology; Nursing; Gerontology; Lifelong learning

2026-03-01https://doi.org/10.1521/pdps.2026.54.1.13Psychodynamic Psychiatry 20261DETERMINANTES DO CRESCIMENTO ECONÔMICO EM MUNICÍPIOS BRASILEIROS COM DIFERENTES PORTES POPULACIONAIS: UMA ANÁLISE EMPÍRICA PARA O PERÍODO DE 2000 A 2020Com objetivo de avaliar se a heterogeneidade entre municípios brasileiros com diferentes portes populacionais demandaria estímulos específicos ao crescimento econômico local, utilizou-se um painel-espacial com variáveis de controle, dummies interativas e dados referentes aos anos de 2000, 2010 e 2020. Estimou-se que a efetividade e a significância das variáveis testadas diminuem conforme aumenta a faixa populacional; logo, haveria mais espaço para intervenções econômicas nos municípios menores. Em locais com até 25 mil habitantes, ter vizinhos mais populosos revelou-se favorável; no entanto, isso se tornaria prejudicial àqueles com 25 a 50 mil habitantes. Investimentos públicos, melhorias na educação e menor proporção de jovens na população impulsionariam a economia de municípios com até 50 mil habitantes. A especialização produtiva mostrou-se vantajosa para locali dades com até 100 mil habitantes. Enquanto a falta de saneamento básico prejudicaria municípios de pequeno e médio porte. A concentração industrial e de serviços beneficiaria locais com menos de 500 mil habitantes, mas a dependência da administração pública seria um entrave. O crédito bancário favoreceria municípios com 50-500 mil habitantes e os gastos correntes poderiam beneficiar todas as faixas populacionais. Portanto, cada município parece demandar políticas específicas voltadas à resolução dos problemas típicos do porte populacional ao qual pertence.Tiago Alves da Silva; Vinícius de Azevedo Couto Firme

Population; Working hours; Humanities; Political science

2026-01-03https://doi.org/10.22395/seec.v29n66a5085Semestre Económico 202613PC-041 Getting the dose right: evaluating consistency in oral compounding<h3>Background and Importance</h3> In daily (hospital) pharmacy practice, extemporaneous compounding remains a vital solution for patients with limited commercial options - especially in paediatric and geriatric care. Yet, ensuring consistent dosing across preparations is a known challenge. To support pharmacists in delivering safe and reliable care, we consolidated previously generated and new stability data and calculated content uniformity across multiple compounded suspensions using a single, standardised vehicle. This approach offers practical insights into dose consistency and helps address long-standing concerns around variability in extemporaneous formulations. <h3>Aim and Objectives</h3> To assess dose uniformity and stability in extemporaneously compounded oral suspensions prepared with SyrSpend SF PH4. By combining results from previously conducted studies, we aim to provide (hospital) pharmacists with a clearer understanding of the accuracy and reliability of these suspensions. <h3>Material and Methods</h3> The analysis included 180 formulations containing 127 active pharmaceutical ingredients (APIs), with 5,700 samples stored at room temperature and under refrigeration. Formulations were prepared under controlled laboratory conditions using validated compounding procedures and analysed with stability indicating HPLC-UV methods. Method specificity was confirmed through forced degradation. To mimic routine patient use, samples were manually agitated before six aliquots were drawn from the centre of each container at day 0, 7, 14, 30, 60, and 90. Content uniformity was assessed using USP <905> acceptance criteria, adjusted to account for the available sample size. Chemical stability was determined by comparing recovery values to initial concentrations. <h3>Results</h3> All formulations tested met the acceptance limits of both the United States Pharmacopeia (USP) and the British Pharmacopoeia (BP). Average recovery values were 99.81% at room temperature and 100.21% under refrigeration, with no samples exceeding USP maximum limits. Mean concentrations remained within 90.86% and 109.91% of label claim, indicating accurate and consistent dosing. These findings confirm that SyrSpend SF PH4 maintains content uniformity and chemical stability across a wide range of APIs under different storage conditions. <h3>Conclusion and Relevance</h3> This study provides (hospital) pharmacists with a practical, evidence-based framework for dose accuracy in extemporaneous compounding. Demonstrating reliable content uniformity and stability across multiple APIs and storage conditions, it supports safer, more standardised preparation of oral suspensions. These results can strengthen internal quality assurance processes and reinforce confidence in everyday compounding decisions. <h3>Conflict of Interest</h3> Corporate sponsored research or other substantive relationships: Carolina Schettino Kegele, Hudson Polonini and Eli Dijkers are employees of Fagron Group. The University of Athens has been provided a financial compensation to cover the costs of executing part of the stability studies presented in this abstract.C Schettino Kegele; H Polonini; Eli Dijkers; M Kostakis

Compounding; Consistency (knowledge bases); Dosing; Reliability (semiconductor); Pharmacy; Repeatability; Pharmacopoeia; Medicine; Medical physics; Sample (material); Dosage form; Stability (learning theory)

2026-03-01https://doi.org/10.1136/ejhpharm-2026-eahp.104 20261COMUNICAÇÃO AUDIOVISUAL COMO ESTRATÉGIA DE SENSIBILIZAÇÃO DE PROFISSIONAIS DA SAÚDEObjetivo: Analisar as evidências da literatura sobre o uso de vídeos educativos como estratégia de comunicação audiovisual na sensibilização e formação de profissionais da saúde. Método: Revisão integrativa conduzida segundo as diretrizes do PRISMA. As buscas foram realizadas nas bases SciELO, LILACS, PubMed, BVS e repositórios institucionais, incluindo estudos publicados entre 2019 e 2024. Após aplicação dos critérios de elegibilidade, 17 estudos compuseram a amostra. Resultados: Emergiram cinco categorias: rigor metodológico na construção dos vídeos; sensibilização para mudança de atitudes profissionais; potencial multimodal da linguagem audiovisual; promoção da humanização e do acolhimento; e lacunas na literatura e necessidade de institucionalização. Conclusão: Os vídeos educativos configuram-se como estratégias relevantes para a formação em saúde, com potencial para qualificar práticas profissionais, desde que integrados a políticas institucionais e sustentados por evidências de impacto longitudinal. DESCRITORES: Educação em Saúde; Comunicação Audiovisual; Profissionais de Saúde; Vídeos Educativos; Formação Profissional.Ewelyne Louzada Santana; Grace Kelly Silva de Freitas; Eduardo Picanço Cruz

Context (archaeology); Health professionals; Reading (process); Perspective (graphical); Humanities; Philosophy; Psychology; Medicine

2026-03-18https://doi.org/10.36489/nursing.2026v31i334p13318-13332Nursing Edição Brasileira 20261Maximum Clique Detection via Second-Order Local Statistics Theoretical and Experimental Analysis on DIMACS BenchmarksWe present a polynomial-time heuristic algorithm for the Maximum Clique Problem based on second-order local statistics (common neighborhood intersections). The method finds optimal solutions on 29 of the 38 DIMACS benchmark instances with proven or best-known optima (76.3%), achieving 100% success on all pure random graphs G(n, p), small adversarial instances, and small algebraic instances. On the three large open instances without proven optima (C500.9, C1000.9, and C2000.9), it reaches solutions within 1–5 vertices of the current best-known values. We develop a quantitative theoretical model centered on the difficulty metric ρ = ω/√(p²n), which classifies instances into three distinct regimes with provably different failure mechanisms: Regime 1 (ρ ≲ 1.5, guaranteed exact recovery via martingale analysis), Regime 2 (ρ > 1.5, accumulated greedy error partially corrected by local swaps), and Regime 3 (adversarial calibration that destroys all polynomial local signals). Formal results include a correctness theorem for Regime 1 (Theorem 6.6), a calibration barrier theorem (Theorem 6.9), correction capacity bounds (Theorem 6.11), a negative result on multi-scale block sampling (Theorem 6.15), and an asymptotic tractability conjecture for natural cliques in G(n, p) (Conjecture 6.14). The algorithm runs in O(p³n⁴ log n) worst-case time with bitset optimizations and exhibits empirical O(n³ log n) behavior on DIMACS instances. A complete, deterministic C implementation (∼600 LOC), all experimental data, and proofs are provided.Wlymarvin Santos Oliveira

Correctness; Mathematical proof; Local optimum; Clique; Heuristic; Stochastic block model; Greedy algorithm; Generalization; Matroid; Benchmark (surveying); Mathematics; Mathematical optimization; Discrete mathematics; Algorithm; Metric (unit); Minification; Deterministic algorithm; Algebraic number

2026-02-24https://doi.org/10.5281/zenodo.19105199Zenodo (CERN European Organization for Nuclear Research) 20261Antimetastatic activity evaluation of diamides inspired by SRPK inhibitor N-[2-(piperidin-1-yl)-5-(trifluoromethyl) phenyl] isonicotinamide (SRPIN340)This study reports the synthesis and cytotoxic evaluation of twenty-two diamides inspired by N -[2-(piperidin-1-yl)-5-(trifluoromethyl)phenyl]isonicotinamide (SRPIN340), an ATP-competitive inhibitor of the oncogenic serine/arginine protein kinases SRPK1 and SRPK2. The diamides were synthesized via Brønsted acid-catalyzed azlactone ring-opening and characterized by IR, HRMS, and NMR (¹H and ¹³C) techniques. Their cytotoxicity was assessed using MTT assays against HeLa, HepG2, and 4T1 tumor cell lines, as well as non-tumor VERO and HEK293 cells. Among them, N -(2-((2-((4-fluorophenyl)amino)-5-(trifluoromethyl)phenyl)amino)-2-oxoethyl)benzamide ( 4h ) exhibited significant cytotoxicity, reducing 4T1 cell migration and colony formation. Moreover, 4h impaired SRPK1 nuclear shuttling, suggesting anti-SRPK activity, corroborated by molecular docking, which shows that 4h binds to the ATP site of SRPK1/2. Molecular dynamics simulations for 70 ns demonstrate that the inhibitors 4h and SRPIN340, when complexed with SRPK1 and SRPK2, maintain structural stability throughout the simulation, remaining within the ATP-binding region. The lowest binding free energy, as predicted by the MM/PBSA method for compound 4h in both kinases, suggests the potential for dual inhibition of these enzymes. Overall, this study highlights a promising diamide scaffold for developing antitumor and antimetastatic agents, reinforcing the relevance of SRPK1/2 as therapeutic targets.Michelle Peixoto Rodrigues; Samuel Inácio da Silva Paiva; Juliana Ferreira de Souza; Raoni Pais Siqueira; Éverton de Almeida Alves Barbosa; Alex Ramos de Aguiar; Marcus Vinícius de Andrade Barros; Deborah Campos Thomaz; Laís Azevedo Rodrigues; Juliana Lopes Rangel Fietto; Giovanni W. Amarante; Fabrício Marques de Oliveira; Adilson Vidal Costa; Osmair Vital de Oliveira; Gustavo Costa Bressan; Róbson Ricardo Texeira

Isonicotinamide; Deblocking filter; Biological activity; Chemistry; Combinatorial chemistry; Stereochemistry; Organic chemistry

2026-03-18https://doi.org/10.1016/j.molstruc.2026.146020Journal of Molecular Structure 20261Caminhos e obstáculos da pesquisa teórica na Obra Completa de C. G. JungDiante da escassez de estudos sobre metodologia de pesquisa na psicologia analítica, este artigo tem como objetivo propor um método de pesquisa teórica na Obra Completa de Carl Gustav Jung, considerando as dimensões conceituais e históricas dessa abordagem psicológica. O artigo oferece orientações preliminares para pesquisadores, abordando questões sobre o acesso à biografia de Jung e analisando os traços estilísticos e características de sua escrita. Além disso, discute a organização da Obra Completa e seu desenvolvimento como projeto editorial. Por fim, apresenta-se um modelo de pesquisa que busca abranger a complexidade e amplitude do pensamento de Jung, conectando a dimensão crítica e histórica. Para a aplicação desse método, é essencial que o pesquisador utilize uma variedade de fontes, tenha familiaridade com os textos de Jung e estruture sua pesquisa em etapas bem definidas. Esse modelo visa ser uma abordagem adaptável para quem deseja aprofundar-se nas bases conceituais da psicologia analítica.José Davi de Almeida Lira; Liviane Damasceno Vidal; Walter Melo

Perspective (graphical); Reflexive pronoun; Order (exchange); Subject (documents); Context (archaeology); Philosophy; Humanities; Epistemology; Sociology

2026-03-17https://doi.org/10.5380/riep.v29i3.97132Interação em Psicologia 20261Updated distribution range of two worm lizard species (Amphisbaena alba and A. fuliginosa) based on citizen science and literature reviewSleep-disordered breathing is characterized by airway dysfunction that can occur in any age, but most prevalent in children, caused by the occurrence of respiratory effort, snoring or even by apnea during sleep. Therefore, the aim of this study was to survey the prevalence of sleep disorders associated with malocclusion in children aged 3 to 12 years in Mineiros, State of Goiás, Brazil. Material and Methods: this is a field research with a sample of 99 children affected by some type of sleep-disordered breathing and malocclusions. Data were collected through a questionnaire about sleep-disordered breathing and a clinical record carried out through intraoral clinical examination. Results: among the 24 children with SDB, 17 had SDB and Malocclusion, which is 70.8% of the children had SDB associated with malocclusion. Of the 75 children without SDB, 11 (14.7%) had malocclusion. Conclusion: No significant differences were found between sleep-disordered breathing and sex-related malocclusions.Henrique J. Oliveira; Vanessa Nocelli; Henrique C. Costa

Airway; Lizard; Breathing; Sleep apnea; Apnea; Distribution (mathematics); Range (aeronautics); Medicine; Population; Demography; Ecology; Large sample; Mouth breathing; Environmental health; Predation

2026-03-18https://doi.org/10.17161/randa.v33i1.23984Reptiles & Amphibians 20261Explorações sobre o tema das drogas a partir da psicologia analítica na contemporaneidadeCarl G. Jung (1875-1961) tratou de pacientes com problemas relacionados ao álcool e teve influência na fundação dos Alcoólicos Anônimos (AA). A despeito de ter tomado conhecimento sobre os psicodélicos, jamais os experimentou e desaprovava seu uso. No campo da psicologia analítica, há estudos sobre o tema das drogas, mas tal temática foi, por vezes, retratada apenas em sua faceta negativa. O presente trabalho visou verificar quais as tendências das pesquisas hodiernas sobre drogas que recorreram à psicologia analítica para sua apreciação, atualizando e ampliando uma revisão integrativa conduzida por Beserra (2022). Constatou-se não ser mais pertinente afirmar que os estudos na interface entre tais áreas são de número reduzido. Classificamos os estudos selecionados em duas matrizes: psicodélicos e adicções. As substâncias mais estudadas foram a ayahuasca e o álcool, havendo predominância metodológica de ensaios e estudos conceituais; investigações de caráter hermenêutico e heurístico; estudos de caso ou casos clínicos; e pesquisas fenomenológicas. Ponderou-se sobre as contribuições recíprocas entre as duas áreas e possibilidades de investigações futuras foram delineadas.Ricardo Nogueira Ribeiro; Walter Melo

Perspective (graphical); Field (mathematics); Theme (computing); Confessional; Criticism; Humanities; Philosophy; Psychology; Sociology

2026-03-17https://doi.org/10.5380/riep.v29i3.93322Interação em Psicologia 20261Epidemiologia da paralisia cerebral no Brasil pela perspectiva da Classificação Internacional de Funcionalidade, Incapacidade e SaúdeResumo Objetivo Estabelecer uma descrição geral das pessoas com paralisia cerebral (PC) no Brasil, incluindo a epidemiologia, características clínicas, funcionalidade e acesso à reabilitação e equipamentos, pela perspectiva da Classificação Internacional de Funcionalidade, Incapacidade e Saúde (CIF), utilizando dados preliminares do Registro Brasileiro de Paralisia Cerebral (RB‐PC). Método Os dados foram extraídos do RB‐PC, que está em andamento, e é realizado com indivíduos com PC com idades entre 0 e 100 anos. As informações coletadas incluíram fatores de risco etiológicos e, a partir da CIF, fatores pessoais e relacionados à saúde, fatores ambientais, estruturas e funções do corpo, atividade e participação. Resultados Foram incluídos 1098 participantes (mediana de idade 9 anos [intervalo interquartil 5–15 anos]; 57,6% do sexo masculino). A maioria das lesões cerebrais ocorreram no período pré‐ ou perinatal (68,1%), sendo o nascimento prematuro (44,8%) e a asfixia perinatal (51,1%) fatores de risco comuns. A PC pós‐neonatal (>28 dias) foi frequentemente relacionada a infecções (23,0%). Um terço de todas as crianças foi diagnosticado antes dos 6 meses de idade. A PC espástica bilateral predominou (59,4%), e 54,9% foram classificados nos níveis IV ou V do Sistema de Classificação da Função Motora Grossa. Condições associadas incluíram epilepsia (57,5%), luxação/subluxação de quadril (31,0%) e comprometimento intelectual (55,3%). Foram relatadas limitações graves de atividade como, por exemplo, vestir‐se (58,9%). Considerando a participação, 10,0% nunca frequentaram a escola. Entre as barreiras ambientais, 67,7% não possuíam adaptações domiciliares, 14,0% não estavam recebendo reabilitação e 44,7% não dispunham de dispositivos de auxílio necessários. Interpretação O RB‐PC destaca necessidades substanciais não atendidas entre indivíduos com PC no Brasil.Hércules Ribeiro Leite; Luana Cristina da Silva; Elton Duarte Dantas Magalhães; Israt Jahan; Nadia Badawi; Gulam Khandaker; Maysa Ferreira Martins Ribeiro; Juliana de Alcântara Moreira Pereira; Luma Sthephanine Viana Roque da Silva; María de las Mercedes Ruiz Brünner; Paula Silva de Carvalho Chagas

Cerebral palsy; Gait; Epilepsy; Diplegia; Medicine; Pediatrics; Gynecology

2026-03-20https://doi.org/10.1111/dmcn.70244Developmental Medicine & Child Neurology 20261Maximum Clique Detection via Second-Order Local Statistics Theoretical and Experimental Analysis on DIMACS BenchmarksWe present a polynomial-time algorithm for the Maximum Clique Problem (MCP) based on second-order local statistics (common neighborhood intersections), now extended to five phases (0–4). The algorithm finds optimal solutions on 33 of the 38 DIMACS benchmark instances with proven or best-known optima (86.8%), achieving 100% success on all pure random graphs G(n, p), all adversarial degree-compensated instances (brock family, 100%), all regular algebraic instances (hamming10-4, 100%), and 60% of planted clique instances. On the three large open instances without proven optima (C500.9, C1000.9, and C2000.9), it reaches solutions within 1–5 vertices of the current best-known values. Two new algorithmic phases are introduced: Phase 3 (ratio-slice exploration) detects distributional asymmetry in the restricted-degree profile within cells without any external knowledge of graph type, resolving brock800 (gap 0) and hamming10-4 (gap 0); Phase 4 (swap chain refinement) traverses the local neighborhood of the solution in swap space via iterative 1→1 swaps, resolving gen200_p0.9_44 (gap 0). We develop a quantitative theoretical model centered on the difficulty metric ρ = ω/√(p²n), classifying instances into three distinct regimes with provably different failure mechanisms: Regime 1 (ρ ≲ 1.5, guaranteed exact recovery via martingale analysis), Regime 2 (ρ > 1.5, accumulated greedy error partially corrected by local swaps), and Regime 3 (adversarial calibration that destroys all polynomial local signals). Formal results include a correctness theorem for Regime 1 (Theorem 6.6), a calibration barrier theorem (Theorem 6.9), correction capacity bounds (Theorem 6.11), a negative result on multi-scale block sampling (Theorem 6.15), and an asymptotic tractability conjecture (Conjecture 6.14). Fourteen partial formal results toward Conjecture 6.14 are presented in Appendix E (F.1–F.14), establishing equivalence to the Grimmett–McDiarmid (1975) gap, open for 50 years, and proving that greedy errors follow a Poisson distribution in the tractable regime (F.14, verified by Monte Carlo). The algorithm runs in O(p³n⁴ log n) worst-case time with bitset optimizations and exhibits empirical O(n³ log n) behavior on DIMACS instances. A complete, deterministic C implementation (~700 LOC), all experimental data, and proofs are provided.Wlymarvin Santos Oliveira

2026-04-04https://doi.org/10.5281/zenodo.19105198Zenodo (CERN European Organization for Nuclear Research) 20261Impacto do racismo estrutural e interpessoal na saúde bucal e nos serviços odontológicosOBJECTIVE: To analyze the role of racism in oral health and access to dental services, considering two impact pathways: structural racism and interpersonal racism. METHODS: A cross-sectional study with 686 undergraduate students, which analyzed two categories of outcomes: those related to oral health (self-perception, oral health impairment, and tooth loss) and those related to access to/perception of the quality of dental services (access to services, recent use, and evaluation of care). Exposures were race/color, racial discrimination, and characterization of the neighborhood environment. Prevalence ratios were estimated using Poisson regression with robust variance, with adjustments guided by directed acyclic diagrams. RESULTS: Black and brown people had a higher prevalence of negative self-perception (black: PR = 1.56; 95%CI 1.14-2.13; brown: PR = 1.53; 95%CI 1.14-2.05), tooth loss (black: PR = 1.99; 95%CI 1.33-2.97), lack of access to dental services (black: PR = 3.08; 95%CI 1.06-8.95; brown: PR = 3.78; 95%CI 1.49-9.59), and negative evaluation of care (black: PR = 1.63; 95%CI 1.08-2.45; brown: PR = 1.64; 95%CI 1.12-2.39). Racial discrimination was associated with lack of access (PR = 4.34; 95%CI 1.45-12.95), recent non-use of services (PR = 1.74; 95%CI 1.31-2.31) and negative evaluation of care (PR = 1.51; 95%CI 1.01-2.25). And living in neighborhoods with fewer physical and social problems was associated with a lower prevalence of negative self-perception (PR = 0.70; 95%CI 0.54-0.90), compromised oral health (PR = 0.87; 95%CI 0.76-0.99), lack of access (PR = 0.42; 95%CI 0.18-0.98), and negative evaluation of care (PR = 0.56; 95%CI 0.40-0.79). CONCLUSIONS: The findings show that racism impacts oral health through structural and interpersonal channels and highlight the urgency of broad and effective strategies to reduce the inequities affecting racialized groups.Rafaela de Oliveira Cunha; Isabel Cristina Gonçalves Leite; Mário Círio Nogueira

Racism; Interpersonal communication; Oral health; Psychometrics of racism; Interpersonal relationship; Race (biology); Psychology; Social psychology; Health equity; Mental health; Public health; Medicine

2026-04-22https://doi.org/10.11606/s1518-8787.2026060007164Revista de Saúde Pública 20261Unveiling the Probiotic Properties of Lacticaseibacillus paracasei UFTM 2.9 Through Probiogenomic AnalysisLactic acid bacteria (LAB) comprise a group of Gram-positive bacteria with biotechnological applications. LAB, including Lacticaseibacillus spp., are recognized as potential probiotics due to their ability to confer benefits to the host. Here we employ probiogenomic and in vitro analyses to characterize the probiotic potential of Lc. paracasei UFTM 2.9, a LAB that previously demonstrated probiotic properties in vitro. The draft genome of Lc. paracasei UFTM 2.9 comprises 127 contigs, totaling 3 216 252 base pairs, with a GC content of 46.20%. The bacteria showed metabolic versatility, growing in five carbon sources. A total of 170 genes potentially associated with probiotic characteristics were identified, with functions linked to stress resistance (n = 106), adhesion (n = 12), biosynthesis of vitamins (n = 10), and others. No virulence genes or CRISPR elements were detected, and two phages were identified in Lc. paracasei UFTM 2.9. Gene clusters encoding bacteriocins were detected and confirmed in vitro. Lc. paracasei UFTM 2.9 inhibited all indicator bacteria tested (n = 12), including strains of Listeria innocua, Staphylococcus aureus, Streptococcus agalactiae, and Escherichia coli. The results indicate the potential use of Lc. paracasei UFTM 2.9 as a probiotic, considering its genetic potential to express traits of interest and survive in the gastrointestinal tract (GIT).Bárbara Ribeiro Fonseca; Yasmin N. V. Sabino; Beatriz M. O. Rocha; Vasco A. C. Azevedo; Bertram Brenig; Siomar Soares; Leandro Nascimento Lemos; Livia Bordalo Tonucci; Sheila C. P. D. Luquetti; Aline D. Paiva; Julliane D. Medeiros; Alessandra B. F. Machado

Probiotic; Bacteriocin; Bacteria; Gene; Virulence; Genome; Human gastrointestinal tract; Lactic acid; Biology; Microbiology; Gastrointestinal tract; Genetics; Bacterial genetics; Pathogenic bacteria

2026-03-01https://doi.org/10.1002/mnfr.70441Molecular Nutrition & Food Research 20261Acesso a Saúde de Mulheres Privadas de Liberdade: Elucidação Necessária para Implantação do Cuidado FarmacêuticoIntrodução: A Política Nacional de Atenção Integral à Saúde das Pessoas Privadas de Liberdade no Sistema Prisional (PNAISP) prevê a inclusão da População Privada de Liberdade (PLL) na Rede de Atenção à Saúde por meio das Equipes de Atenção Básica Prisional (EABP) (1). Entretanto, a habilitação dessas equipes é um desafio (2). Além disso, somada a estigmatização e a discriminação nos serviços de saúde externos, o acesso à saúde da PPL é mais dificultado (3,4). Nesse cenário, instituições como a Associação de Proteção e Assistência aos Condenados(APAC) se destacam por valorizar a dignidade humana e promover a saúde como parte da ressocialização (5,6). Contudo, persiste uma lacuna sobre o acesso dessas unidades à Atenção Primária à Saúde (APS) e sua inserção na PNAISP. Objetivo: Descrever o acesso à saúde via APS de mulheres privadas de liberdade de um sistema carcerário não tradicional do tipo APAC e como este se relaciona à PNAISP, sob a perspectiva dos funcionários da APAC. Métodos: Estudo qualitativo descritivo em uma unidade prisional feminina APAC do leste de MG. Esse estudo faz parte da etapa inicial de um projeto de pesquisa em andamento que visa implantar o serviço de acompanhamento farmacoterapêutico no local. Os dados foram coletados de março a julho de 2024 por meio de observação participante e entrevistas semi-estruturadas. Os dados foram registrados por diário de campo e gravador de som, sendo transcritos, analisados de acordo com análise de conteúdo de Bardin e descritos. A pesquisa foi aprovada no Comitê de Ética em Pesquisa sob o número CAAE 75609123.2.0000.5147. Resultado e Conclusão: Foram entrevistados oito funcionários (E1 a E8). Em relação ao acesso à APS, os funcionários concordam que é limitado, como demonstrado nas seguintes falas: E7: “Eu tenho que levar uma por uma no posto de saúde se eu quiser que todas tenham acesso à rede pública”. Outro ponto de convergência dos entrevistados é a diferença de acesso à APS entre a APAC e o sistema tradicional, como relatado por E3: “A APAC tem o mesmo público do sistema prisional, que são pessoas privadas de liberdade, fato”. É possível perceber que não há uma clareza que a PNAISP é a política que assegura o direito, como demonstrado pelas falas: E6: “Falta esse conhecimento sabe? [...] como a gente vai brigar por algo que a gente não sabe o que é”. E4: “Inclusive a gente não tem (se referindo à PNAISP), [...] isso prejudica diretamente a APAC”. E como consequência da falta de implantação da PNAISP, o acesso à APS fica atrelado às relações interpessoais, como demonstrado por E7: “Uma funcionária da APAC, teve uns desentendimentos com algumas pessoas (da APS) e a gente foi cortado de muitas coisas”. O acesso à saúde das mulheres privadas de liberdade da APAC é limitado, principalmente devido à falta de implantação da PNAISP. O estudo aponta a necessidade de explorar os desafios e propor soluções para garantir esse direito, que é fundamental para a efetiva implementação do cuidado farmacêutico no local.Clarissa Campos Barbosa de Castro; Mafalda Miranda; Anna Júlia de Oliveira Silva; Carina Carvalho Silvestre; Lorena Rocha Ayres

Free access; Ideal (ethics); Intervention (counseling); Work (physics); Humanities; Medicine; Political science

2026-03-17https://doi.org/10.22563/2525-7323.2026.v11.e00427Jornal de Assistência Farmacêutica e Farmacoeconomia 20261MANEJO TERAPÊUTICO DA DERMATITE ATÓPICA: PROTOCOLOS DE HIDRATAÇÃO E RESTAURAÇÃO DA BARREIRA CUTÂNEAA dermatite atópica (DA) é uma doença cutânea inflamatória crônica caracterizada por prurido intenso, placas eritematosas descamativas e xerose cutânea persistente, com elevada prevalência na população pediátrica. A fisiopatologia da DA é multifatorial, pois envolve uma interação complexa entre predisposição genética, desregulação imunológica e, fundamentalmente, a disfunção da barreira epidérmica. O presente estudo trata-se de uma revisão bibliográfica narrativa, fundamentada em artigos publicados nos últimos cinco anos na base de dados PubMed, com o objetivo de compilar e avaliar criticamente evidências científicas recentes sobre o manejo terapêutico da dermatite atópica, com ênfase na hidratação e na restauração da barreira cutânea. Os resultados evidenciam que o diagnóstico da doença permanece predominantemente clínico e que a terapia básica com emolientes representa o pilar central do tratamento em todas as fases da doença. O emprego de formulações ricas em lipídios fisiológicos é determinante para a recomposição da barreira cutânea, pois promove a integridade do estrato córneo e a consequente redução da perda de água transepidérmica (TEWL), além de mitigar a penetração de agentes irritantes exógenos. Além disso, emolientes com ativos adicionais e estratégias voltadas ao equilíbrio do microbioma cutâneo têm mostrado benefícios na redução dos sintomas e na diminuição da necessidade de terapias anti-inflamatórias mais intensas. Em suma, o manejo eficaz da DA depreende uma abordagem multimodal e integrada. Esta deve priorizar a restauração da função de barreira, a identificação e exclusão de gatilhos ambientais específicos e o escalonamento racional entre terapias tópicas e sistêmicas, conforme a fenotipagem e gravidade do quadro clínico.Luane Nascimento Ávila; Rebeca Coutinho da Silva; Nicolle Dominick Ferreira Macedo Cadete; Alyne Costa Silva; Julia Leren Alves De Souza

Safety profile; Clinical Practice; Signs and symptoms; Medicine

2026-03-20https://doi.org/10.56238/arev8n3-098Aracê. 20261Budismo e estoicismo:Este trabalho analisa as semelhanças e diferenças entre o Budismo e oEstoicismo, duas tradições filosóficas que abordam a morte e a busca pela serenidade demaneiras profundas e distintas. O Budismo, com sua ênfase no desapego,impermanência e no ciclo de nascimento e renascimento, propõe a meditação e areflexão como meios para alcançar a paz interior, superando o sofrimento humano. Poroutro lado, o Estoicismo, originado na Grécia antiga, ensina a aceitação da morte comoparte da natureza e busca a tranquilidade por meio da razão, da virtude e do controle dasemoções. Ambos os sistemas filosóficos oferecem ferramentas para lidar com ainevitabilidade da morte, mas enquanto o Budismo foca na superação do ego e natransição para um estado de não-sofrimento, o Estoicismo enfatiza a resiliência diante daadversidade e a busca por uma vida virtuosa. Este estudo propõe uma reflexão sobrecomo essas filosofias podem contribuir para uma abordagem serena e equilibrada da vidae da morte, revelando que, embora com métodos diferentes, ambas visam àtransformação do ser humano e à busca pela paz interior.Régys Perdigão

Relation (database); Action (physics); Set (abstract data type); Human life; Philosophy

2026-03-18https://doi.org/10.48075/rd.v12i1.37251Revista DIAPHONÍA 20261Um Estudo Comparativo de Modelos de Autoencoders para Redução de Dados Visuais em Operações de Veículos Aéreos Não Tripulados (UAV) em Operações de Busca e Resgate (SAR)This article evaluates the performance of different autoencoder architectures, conventional, variational, and redundancy-penalized, for image compression in autonomous aerial vehicles during search and rescue operations. The main hypothesis anticipated that penalized models would outperform others, balancing computational efficiency and reconstruction fidelity. Experiments were conducted using the SARD 2 dataset, and the analysis considered PSNR, SSIM, MS-SSIM, compression rate, and processing time. Results showed that the conventional autoencoder achieved higher reconstruction quality, while the penalized model excelled in computational efficiency. The variational autoencoder presented intermediate performance. Contrary to expectations, the hypothesis was not fully confirmed, highlighting the need to balance quality and efficiency according to operational constraints. Statistical analysis (Kruskal-Wallis test) indicated significant differences among models. It is important to note the limitation regarding end-to-end latency assessment, as only compression and reconstruction times were measured in the experimental environment. For future work, evaluation in real transmission scenarios and analysis of energy impact and adaptive approaches for different operational conditions are recommended.Samuel Cotta; Mário A. R. Dantas; Marco Antônio Pereira Araújo

Autoencoder; Compression (physics); Latency (audio); Artificial neural network; Computational model; Data compression; Iterative reconstruction; Artificial intelligence; Computer science; Computer vision; Machine learning; Pattern recognition (psychology); Image processing; Computational complexity theory

2026-03-16https://doi.org/10.22409/4sw09a96Sustainable Business International Journal 20261IMPACTOS DA SUPLEMENTAÇÃO DE b-HIDROXI-b-METILBUTIRATO (HMB) NA FORÇA, RECUPERAÇÃO MUSCULAR E RESISTÊNCIA EM ATLETAS COMPARADOS A PRATICANTES INICIANTES DE EXERCÍCIOS FÍSICOS: UMA REVISÃO NARRATIVAEsse artigo buscou investigar as evidências disponíveis e discutir as lacunas existentes sobre a suplementação de HMB em atletas comparados com praticantes iniciantes de exercícios físicos. Foram incluídos 22 artigos sobre HMB e nutrição. A busca foi realizada na plataforma PUBMED e Scielo. A estratégia de busca usada foi uma combinação das palavras-chave HMB, suplementação, nutrição esportiva, atletas, em inglês e português. Os artigos selecionados foram avaliados em relação ao objetivo do estudo, critérios para o tipo de amostra, desenho (ensaio clínico, observacional, revisão prévia, etc.), duração, instrumentos; resultados principais e conclusão. O estudo foi dividido em 4 grandes eixos: 1) Mecanismos de Ação do HMB, 2) Evidências em Força Muscular, 3) Evidências em Recuperação Muscular, 4) Formas de HMB. Evidências científicas sugerem que o uso de HMB, tanto na forma de sal de cálcio (HMB-Ca) quanto de ácido livre (HMB-FA), pode contribuir para melhorar o desempenho físico, a força e a recuperação muscular, sendo a forma de ácido livre associada a maior taxa de absorção e biodisponibilidade.Patrícia Rodrigues Ferreira; Maycon Pereira Alves Louro; Letícia Adelaide de Lima; Maria Eduarda de Oliveira Soares; Mateus Tenente Gonçalves; Natalia Rodrigues dos Reis

Athletes; Physical activity; Context (archaeology); Subject (documents); Humanities; Art; Psychology

2026-03-20https://doi.org/10.51891/rease.v12i3.24808Revista Ibero-Americana de Humanidades, Ciências e Educação 20261Net CO 2 Emissions From Dry Inland Waters Persist in the Presence of VegetationAbstract Many inland waters are shrinking due to shifts in climate and water diversion for human uses. As they dry out, their exposed sediments emit large amounts of carbon dioxide (CO 2 ) to the atmosphere. However, current global estimates of CO 2 emissions from dry inland waters are derived exclusively from bare sediment dark‐chamber measurements that do not account for the colonization of desiccated areas by vegetation. To understand the impact of vegetation on CO 2 emissions from dry sediments, we analyzed 164 dry inland water bodies across five climatic regions and five inland water body types (lakes, ponds, reservoirs, streams and wetlands). On average, within vegetated zones, vegetation occupied 47 ± 35% in measured biomass quadrants. Light‐induced decreases in instantaneous CO 2 emissions in vegetated dry sediments were lower (mean ± SD = −3.7 ± 12.9 mmol CO 2 m −2 hr −1 ) than increases during dark conditions (14.7 ± 20.1 mmol CO 2 m −2 hr −1 ). Diel (24‐hr) CO 2 emissions from dry, vegetated sediments (mean ± SD = 100 ± 261 mmol CO 2 m −2 d −1 ) were 25% lower than in bare sediments (133 ± 245 mmol CO 2 m −2 d −1 ). These results indicate that vegetation can partially off‐set sediment respiration, although the magnitude of this effect is insufficient to switch dry beds from net sources to net sinks of carbon.Krati Sharma; Soren Brothers; Susana Bernal; Núria Catalán; Philipp S. Keller; Matthias Koschorreck; Sarian Kosten; Catherine Leigh; Daniel von Schiller; Ada Pastor; Aitor Larrañaga; Akif Arı; Alba Camacho‐Santamans; Alistair Grinham; Anna Lupon; Annika Linkhorst; Arturo Elosegi; Biel Obrador; Bradley D. Eyre; Carolina Trochine; Claumir César Muniz; Claudia Feijoó; Clément Duvert; Enrique Moreno‐Ostos; Erica A. García; Ernades Sobreira Oliveira; Florencia Cuassolo; Hugo Rafael Fernandez; Jacob Yeo; Joanne M. Oakes; José R. Paranaíba; Josephine Pegg; Julieta Anselmo; Jorge Juan Montes‐Pérez; Laura B. van den Heuvel; Lishan Ran; Lopes Lazaro Wilkinson; Lluís Gómez‐Gener; M. Arroita; Margaret Shanafield; María de L. Gultemirian; María Isabel Arce; Melissa Cobo; Maria Mar Sánchez-Montoya; Nathan Barros; Naomi S. Wells; Nusret Karakaya; Pelin Ertürk Arı; Quinten Struik; Ralf Aben; Ryan Rimas; Sanjeev Kumar; Sheel Bansal; Siddhartha Sarkar; Sofía Rodríguez‐Gómez; Tao Huang; Teresa Silverthorn; Thibault Datry; Verónica Díaz Villanueva; Rafael Marcé

Carbon dioxide; Vegetation (pathology); Sediment; Hydrology (agriculture); Biomass (ecology); Dry weight; Carbon cycle; Carbon sink; Environmental science; STREAMS; Sink (geography); Dry season; Cycling; Total organic carbon

2026-03-01https://doi.org/10.1029/2025gb008801Global Biogeochemical Cycles 20261Manner adverbs in - mente from Latin to Brazilian PortugueseAbstract This paper investigates the grammaticalization ( Roberts & Roussou 1999 , Lehmann 2015 ) of the adverbial constructions of the X-mente pattern from Latin to Brazilian Portuguese, under the framework of Distributed Morphology ( Halle & Marantz 1993 , Marantz 1997 ). In Latin, these adverbials consisted of the feminine noun mens ‘mind’ and an adjective, and expressed the meaning of ‘in an X manner’ (with ‘X’ representing the adjective). In Brazilian Portuguese, they are formally adverbs, single words composed of a feminine adjective followed by the ending -mente . We propose that the noun mente changed into an adverbial categorizer head ( adv ) while preserving some properties from its lexical origin, notably the feminine gender, which is shared with the adjective to which it merges.Lydsson Agostinho Gonçalves; Bianca Agrelli Rodrigues; Paula Roberta Gabbai Armelin

Adverbial; Adjective; Brazilian Portuguese; Noun; Meaning (existential); Grammaticalization; Head (geology); Infinitive; Linguistics; History; Portuguese; Adverb; Lexical item; Derogation

2026-03-23https://doi.org/10.1075/la.292.03gonLinguistik aktuell 20261Diversidade no JudiciárioPor meio de pesquisa documental e análise quali-quantitativa, este estudo analisa a presença de metas e indicadores voltados à diversidade e inclusão nos planos estratégicos das instituições federais do Poder Judiciário, incluindo Supremo Tribunal Federal (STF), Conselho Nacional de Justiça (CNJ), Superior Tribunal de Justiça (STJ), Superior Tribunal Militar (STM), Tribunal Superior do Trabalho (TST) e Tribunal Superior Eleitoral (TSE), com vigência entre 2021 e 2026. De um total de 382 iniciativas analisadas, que abrangem 203 metas e 179 indicadores, apenas 26 estavam diretamente relacionadas à diversidade e inclusão, o que representa 6,8% (±2,3%) do total. Observou-se que o Supremo Tribunal Federal incorpora 10% de suas metas e indicadores com foco em diversidade, um dos percentuais mais elevados entre os tribunais superiores. A despeito da relevância do tema, poucos órgãos judiciários incorporam indicadores específicos e expressos em seus planejamentos estratégicos, prevalecendo objetivos relacionados à gestão administrativa ou prestação jurisdicional. Portanto, identificam-se oportunidades significativas para fortalecer e expandir essas iniciativas de maneira institucionalizada.Valéria Romão Pasqualini Nerio; Leidy Dayane Paiva de Abreu

Tribunal; Diversity (politics); Power (physics); Political science; Humanities

2026-03-23https://doi.org/10.53798/suprema.2026.v6.n1.a508Suprema - Revista de Estudos Constitucionais 20261Nas Cadeirinhas, muitas histórias para escutarObjetivamos discutir quais são as implicações éticas e epistemológicas das aberturas à escuta do outro realizadas no quadro Cadeirinhas, da TV Globo, no que diz respeito às narrativas de vida e à subjetividade como partes constituintes do jornalismo na atualidade. Mobilizamos duas edições do quadro no programa Fantástico, em 2024, e discutimos em dois eixos a partir de uma perspectiva discursiva respaldada em repertórios teórico-conceituais: (i) narrativas de vida como processos de ressignificação e exposição da intimidade; (ii) subjetividade e alteridade presentes no jornalismo ao dar visibilidade midiática a vidas anônimas. Concluímos que Cadeirinhas é um fazer jornalístico guiado pela subjetividade como marca discursiva na construção narrativa e de abertura à escuta do outro, capaz de produzir um conhecimento desestabilizador, configurando-se como uma pausa no meio do movimento caótico das capitais e da vida urbana.Maurício João Vieira Filho; Mariana Ramalho Procópio

Subjectivity; Hegemony; Context (archaeology); Work (physics); Narrative; Humanities; Sociology; Art

2026-03-23https://doi.org/10.5752/p.2237-9967.2026v15e36945Dispositiva 20261Economic Growth and climate change: bibliometric analysisThe concept of sustainable development emerged in the 1970s as an alternative to uncontrolled economic growth. It gained relevance through the 1972 Club of Rome report, which highlighted the need for balancing economic growth, environmental protection, and social justice. Accordingly, the aims of the present study are to map the progress of the literature on the Economic Growth/Climate Change intersection based on the bibliometric analysis of 5919 documents selected in the Scopus and Web of Science databases (1978-2024) in the R software. Based on the results, there was yearly growth by 13.77% in scientific production. China was the leader in number of publications, and it was followed by the United States and the United Kingdom. Environmental Science, Social Sciences, Economics, Energy and Medicine were the main research/production fields. Institutions such as Tsinghua University and the Chinese Academy of Sciences, and authors like Wang S., Bekun F. and Adebayo T. stood out among the other institutions and authors. According to the analysis, there were fast expansion of scientific production, significant international collaboration and gaps that still demand investigation, besides the underscoring of the relevant global collaboration to find sustainable solutions.Fábio Júnior Clemente Gama; André Vitor Pereira de Melo; Caio Oliveira Azevedo; Bruno Castro Alves; Carla Rocha dos Santos; Kaylane Manuele Nunes Feitoza; Suzana Quinet de Andrade Bastos

Scopus; China; Bibliometrics; Relevance (law); Sustainable development; Climate change; Club; Regional science; Political science; Scientific literature; Web of science; Government (linguistics); Sustainability; Geography; Economic growth

2026-03-23https://doi.org/10.1590/scielopreprints.15511 20261Application of Chitosan Gels and the Impact on Dental and Periodontal Health of Patients: A Systematic ReviewABSTRACT Objective: To identify and discuss the impact of the application of chitosan gels on the dental and periodontal health of patients. Material and Methods: This study was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses, and its protocol was registered in the International Prospective Register of Systematic Reviews. Searches were performed in the Embase, MEDLINE/PubMed, Elsevier/Scopus, and Web of Science databases using the descriptors "dentistry", "chitosan", "gels", "hydrogels", "oral health", "tooth", "gingiva", and "periodontics" combined with the Boolean operators "AND" and "OR". The risk of bias was assessed using the Cochrane Risk of Bias 2 tool for randomized controlled trials. Results: A total of 30 studies were retrieved; after reviewing titles, abstracts, and full articles and applying the inclusion and exclusion criteria, only three were included. Subsequently, two studies were manually added through reference searches, bringing the total to 5. In the overall risk-of-bias analysis, only one study was classified as having a low risk of bias, three as having some concern, and one as having a high risk of bias. Conclusion: Gels containing chitosan appear to have a promising positive impact on patients' dental and periodontal health. However, these results should be evaluated with caution due to the risk of bias identified in the studies.Fernanda Ramos de Faria; Michel de Oliveira Sales Júnior; Amanda Marota de Oliveira; Mariana Simões de Oliveira; Joana Godinho; Luís Jardim; Ana Carolina Morais Apolônio; Márcio José da Silva Campos

Systematic review; Inclusion and exclusion criteria; Protocol (science); Chitosan; Oral health; MEDLINE; Cochrane collaboration; Risk assessment; Medicine; Dentistry; Web of science; Randomized controlled trial; Meta-analysis; Risk analysis (engineering)

2026-01-01https://doi.org/10.1590/pboci.2026.068Pesquisa Brasileira em Odontopediatria e Clínica Integrada 20261Clinical and Sociodemographic Profile of Familial Amyotrophic Lateral Sclerosis Type 8 Compared to the Sporadic FormAbstract Amyotrophic lateral sclerosis (ALS) is a rare degenerative disease of motor neurons, predominantly sporadic, with approximately 10% of the cases showing familial inheritance. To characterize the clinical and sociodemographic profile of patients with familial ALS type 8 (fALS8) and compare it with sporadic ALS (sALS). We reviewed the medical records (1997–2022) from a specialized Brazilian center. Patients with a confirmed diagnosis of ALSs were included, and sociodemographic and clinical data were collected. The sample was composed of 89 ALS patients, with a slight female predominance (53%) and a high frequency of fALS8 cases (45%). The fALS8 patients were diagnosed at a younger age, at approximately 50 years, compared to 53 years among the sALS patients (p = 0.043). Lower limb onset predominated in the fALS8 group (87%), while the sALS group showed more heterogeneous presentations, including bulbar onset (14%). The time until the diagnosis was significantly longer in the fALS8 group compared to the sALS group, both from symptom onset (approximately 51 versus 30 months respectively; p < 0.001) and after admission to a specialized center (7 versus 4 months respectively; p = 0.002). Dysphagia and gastrostomy were more frequent in the sALS group compared to the fALS8 group (p = 0.02 and p < 0.01 respectively), and older age at diagnosis was associated with worse functional scores. The fALS8 group presented with distinct clinical and demographic features compared to the sALS group, including younger age at diagnosis, more homogeneous symptom onset, and lower frequency of dysphagia and need for gastrostomy. The diagnosis was more delayed in the fALS8 group, and older age at diagnosis was associated with worse functional status. The current study contributes to the scarce data on fALS8 in South America.Danilo Jorge da Silva; Sophia Calabria da Silveira; Leonardo Cruz de Souza; Marcelo Maroco Cruzeiro; Thiago Cardoso Vale

Dysphagia; Amyotrophic lateral sclerosis; Medical record; Disease; Age of onset; Homogeneous; Degenerative disease; Medicine; Pediatrics; Central nervous system disease; Internal medicine; Epidemiology; Gastrostomy

2026-03-01https://doi.org/10.1055/s-0046-1817037Arquivos de Neuro-Psiquiatria 20261PORTFÓLIO: VIVÊNCIA NO SISTEMA ÚNICO DE SAÚDE DE JUIZ DE FORA, MINAS GERAIS (VER-SUS JF-MG) - PELO AUMENTO DAS COBERTURAS VACINAIS!Este portfólio apresenta a sistematização e análise crítica da vivência no Programa Nacional de Vivências no Sistema Único de Saúde, realizada em Juiz de Fora, Minas Gerais (VER-SUS JF-MG), em março de 2026, com foco no enfrentamento das baixas coberturas vacinais. A experiência, ancorada na integração ensino-serviço-comunidade, articulou atividades formativas, ações em território e reflexões sobre o cuidado em saúde, evidenciando a complexidade da imunização enquanto prática social. A caracterização do território demonstra um município com estrutura consolidada de Atenção Primária, com ampla cobertura de equipes de saúde da família e estratégias complementares de vacinação. Contudo, os dados epidemiológicos revelam coberturas vacinais aquém das metas preconizadas, especialmente em esquemas infantis e grupos prioritários, indicando fragilidades na adesão, continuidade do cuidado e comunicação em saúde. No cotidiano da vivência, destacam-se a condução de atividades educativas, oficinas e simulações voltadas à hesitação vacinal, bem como a atuação em diferentes cenários do território. Essas experiências evidenciaram que o cuidado em saúde ultrapassa a dimensão técnica, exigindo escuta qualificada, construção de vínculo e leitura contextualizada das demandas da população. As reflexões críticas apontam para os desafios da formação em saúde, incluindo a necessidade de metodologias ativas, preparo para lidar com a intensidade do trabalho no SUS e valorização dos microprocessos do cuidado. A vivência também evidenciou seu potencial transformador, ao promover deslocamentos subjetivos e fortalecer o compromisso ético, técnico e político com o sistema público de saúde. Conclui-se que o VER-SUS JF-MG se configura como uma estratégia potente de formação em saúde, ao possibilitar a articulação entre teoria e prática em contextos reais, contribuindo para a formação de profissionais mais críticos, sensíveis e comprometidos com a transformação das realidades em saúde.Cosme Rezende Laurindo

Population; Work (physics); Perspective (graphical); Reading (process); Amazon rainforest; Metropolitan area; Humanities; Geography; Political science; Sociology; Physics

2026-03-23https://doi.org/10.5281/zenodo.19174637Zenodo (CERN European Organization for Nuclear Research) 20261The higher education market in Brazil: structure and conduct in a non-traditional market *Abstract The higher education product has intrinsic traits that require State intervention in the sector, which hinders the analysis of the industry via traditional methods of the Economics discipline. This study carries out an analysis of the state of competition in the Brazilian higher education sector, focusing on high quality institutions. Specifically, analytical techniques from the field of Industrial Organization and Antitrust practices have been employed to assess structure and conduct. Results showed that public higher education institutions (HEIs) face competitive pressure from high-quality private HEIs. Additionally, relevant markets present a wide scope, with either regional or national range, depending on schools’ quality. In general, markets are not concentrated and do not raise anticompetitive concerns. Independent admissions exams, product differentiation, and price discrimination were identified as the main conducts carried out by schools.João Augusto Ferreira Freire; Silvinha Pinto Vasconcelos; Marcel de Toledo Vieira

Competition (biology); Higher education; Product (mathematics); Quality (philosophy); Product market; State (computer science); Intervention (counseling); Face (sociological concept); Business; Economics; Market structure; Industrial organization; Field (mathematics); Public economics; Market economy; Perfect competition; Private sector; Market competition; Control (management)

2026-01-01https://doi.org/10.1590/1982-3533.2026v35n2.267076Economia e Sociedade 20261Computational cost and accuracy of physics-informed and conventional NNs for immune response modelingThiago E. Fernandes; Rodrigo Weber dos Santos; Marcelo Lobosco

Artificial neural network; Inference; Deep neural networks; Computational model; Artificial immune system; Computer science; Artificial intelligence; Machine learning

2026-01-01https://doi.org/10.2139/ssrn.6434223SSRN Electronic Journal 20261Central Nervous System Manifestations Associated with Hereditary Transthyretin Amyloidosis: a Narrative ReviewAbstract Hereditary transthyretin amyloidosis (ATTRv) is a rare, autosomal dominant, inherited disease caused by variants in the gene encoding the transthyretin (TTR) protein. These variants lead to TTR tetramer destabilization, resulting in the formation and progressive deposition of insoluble amyloid fibrils in various tissues, including those of the central nervous system (CNS). Although previously neglected, the recognition of CNS involvement in ATTRv has become progressively relevant due to prolonged patient survival and the ineffectiveness of the current therapies in addressing CNS synthesis of TTR. The first descriptions of the pathological involvement of the CNS in ATTRv date from the 1960s; however, this topic has not been fully explored. In the present article, the main CNS clinical manifestations of ATTRv, such as transient focal neurological episodes, bleeding complications, leptomeningeal amyloidosis, and cognitive impairment, are reviewed, and the phenotypic variability of this condition is highlighted. A literature review of the PubMed/Medline database was conducted using the following keywords: hereditary amyloidosis, transthyretin amyloidosis, familial amyloidosis, central nervous system, neurological manifestations, leptomeningeal amyloidosis, cognition, and cognitive impairment. Studies published in the last 15 years, including review articles, prospective observational studies, experimental studies and clinical trials, were evaluated. Improving our understanding of CNS involvement in ATTRv will enable the early identification of neurological symptoms in this condition, which will enhance the understanding of the pathophysiological mechanisms and boost the advancement of research, expanding potential treatments and improving the quality of life of these individuals.Pedro Ivo Machado Campos de Araujo Costa; Marcelo Maroco Cruzeiro; Arise Garcia de Siqueira Galil; Thiago Cardoso Vale

Transthyretin; Amyloidosis; Central nervous system; Disease; Narrative review; Pathological; Review article; Genetic heterogeneity; Medicine; Neuroscience; Pathology; Bioinformatics; Phenotype; Amyloid (mycology); Pathophysiology; Cognitive impairment; Identification (biology)

2026-02-01https://doi.org/10.1055/s-0046-1817041Arquivos de Neuro-Psiquiatria 20261PORTFÓLIO: VIVÊNCIA NO SISTEMA ÚNICO DE SAÚDE DE JUIZ DE FORA, MINAS GERAIS (VER-SUS JF-MG) - PELO AUMENTO DAS COBERTURAS VACINAIS!Este portfólio apresenta a sistematização e análise crítica da vivência no Programa Nacional de Vivências no Sistema Único de Saúde, realizada em Juiz de Fora, Minas Gerais (VER-SUS JF-MG), em março de 2026, com foco no enfrentamento das baixas coberturas vacinais. A experiência, ancorada na integração ensino-serviço-comunidade, articulou atividades formativas, ações em território e reflexões sobre o cuidado em saúde, evidenciando a complexidade da imunização enquanto prática social. A caracterização do território demonstra um município com estrutura consolidada de Atenção Primária, com ampla cobertura de equipes de saúde da família e estratégias complementares de vacinação. Contudo, os dados epidemiológicos revelam coberturas vacinais aquém das metas preconizadas, especialmente em esquemas infantis e grupos prioritários, indicando fragilidades na adesão, continuidade do cuidado e comunicação em saúde. No cotidiano da vivência, destacam-se a condução de atividades educativas, oficinas e simulações voltadas à hesitação vacinal, bem como a atuação em diferentes cenários do território. Essas experiências evidenciaram que o cuidado em saúde ultrapassa a dimensão técnica, exigindo escuta qualificada, construção de vínculo e leitura contextualizada das demandas da população. As reflexões críticas apontam para os desafios da formação em saúde, incluindo a necessidade de metodologias ativas, preparo para lidar com a intensidade do trabalho no SUS e valorização dos microprocessos do cuidado. A vivência também evidenciou seu potencial transformador, ao promover deslocamentos subjetivos e fortalecer o compromisso ético, técnico e político com o sistema público de saúde. Conclui-se que o VER-SUS JF-MG se configura como uma estratégia potente de formação em saúde, ao possibilitar a articulação entre teoria e prática em contextos reais, contribuindo para a formação de profissionais mais críticos, sensíveis e comprometidos com a transformação das realidades em saúde.Cosme Rezende Laurindo

Population; Work (physics); Perspective (graphical); Reading (process); Amazon rainforest; Metropolitan area; Humanities; Geography; Political science; Sociology; Physics

2026-03-23https://doi.org/10.5281/zenodo.19174638Zenodo (CERN European Organization for Nuclear Research) 20261Integrating Voltage Stability Into the Static Security Region: A Unified Analytical FrameworkThe increasing penetration of distributed and renewable generation has driven modern power systems closer to their technical limits, making voltage instability a key threat to grid reliability and reducing the operational margin for preventive control and generation redispatch. Traditional steady-state security tools, such as the Static Security Region (SSR), map feasible operating points under steady-state constraints but do not quantify proximity to voltage collapse. This paper proposes an enhanced SSR that integrates a fast, analytically derived Voltage Stability Index (VSI) based on a Thevenin equivalent and load-impedance characteristics, embedding stability-margin information directly into SSR nomograms. The resulting visualization jointly depicts feasibility and voltage-stability robustness, enabling screening and ranking of dispatch points beyond voltage-magnitude compliance. Case studies on the IEEE 9-bus and New England 39-bus systems show that the VSI-based SSR highlights dispatch-dependent low-margin regions that can occur before conventional thermal or voltage limits are reached. Overall, the method provides an efficient, interpretable tool for steady-state security assessment and preventive decision support.Rafael Alberto Garcia Tinoco; João Alberto Passos Filho; Jonathan Muñoz Tabora; Maximiliano Martínez

Thévenin's theorem; Voltage; Electric power system; Key (lock); Margin (machine learning); Grid; Ranking (information retrieval); Reliability (semiconductor); Smart grid; Computer science; Reliability engineering; Stability (learning theory); Voltage droop; Distributed generation; Embedding; AC power; Emulation

2026-01-01https://doi.org/10.1109/access.2026.3677081IEEE Access 20261Public Administration and Agenda Setting: A Systematic Review Across Three PlatformsPurpose: Public administration is profoundly influenced by the sociopolitical context, which shapes its institutional identity, strategies, and agenda. Agenda-setting theory plays a central role in the theoretical debate on Public Policy and Management. This study investigates the contemporary debate on agenda-setting in administrative and organizational studies in Brazil. Design/Methodology/Approach: To conduct the study, a Systematic Literature Review (SLR) was conducted on national and international platforms, including Scielo Brasil, Spell, and Web of Science. Findings: The results show a growth in scientific production in recent years, with greater use of the punctuated equilibrium model in national research and an increase in international collaborations. Emerging themes include climate change, sustainability, and the role of multilateral development banks, especially in Asia. Originality/Value: This research emulates and updates previous works, expanding the search to identify new articles on the topic, thus advancing knowledge about agenda-setting in scientific research on public policy. Keywords: Public Administration; Agenda-Setting; Systematic Literature ReviewArthur de Oliveira Freitas Hoelz Magalhães Lyrio; Luis Eduardo Freitas Diniz e Martins; Fernando Tavares Júnior; Maria Luiza Souza Ferreira

SciELO; Public policy; Systematic review; Public management; Administration (probate law); Knowledge production; Political science; Public administration; Public relations; New public management

2026-03-24https://doi.org/10.5902/1983465993155Revista de Administração da UFSM 20261480: HYPERNATREMIA IN ACUTE TRAUMATIC BRAIN INJURY: A SYSTEMATIC REVIEW AND META-ANALYSISIntroduction: Traumatic brain injury (TBI) may impair sodium regulation due to hypothalamic-pituitary axis dysfunction, potentially leading to hypernatremia. This sodium imbalance has been associated with adverse outcomes in critically ill patients. We conducted a systematic review and meta-analysis to assess whether hypernatremia in TBI is associated with worse clinical outcomes compared to normal or low sodium levels. Methods: A systematic search of PubMed, Embase, and the Cochrane Library was performed to identify observational studies comparing outcomes in TBI patients with hypernatremia versus normonatremia or hyponatremia. Outcomes included mortality, intensive care unit (ICU) length of stay (LOS), and hospital LOS. Data were pooled using random-effects models, and results were presented as odds ratios (OR) or mean differences with 95% confidence intervals (CI). Risk of bias was assessed using the ROBINS-I tool. Results: Eight observational studies were included, involving 93,696 patients, of whom 5,559 developed hypernatremia. Hypernatremia was significantly associated with increased mortality (OR: 1.59; 95% CI: 1.17–2.17; P = 0.01). No significant differences were observed in ICU LOS (mean difference: 1.07 days; 95% CI: –2.09 to 4.24; P = 0.36) or hospital LOS (mean difference: 1.31 days; 95% CI: –24.14 to 26.77; P = 0.84). Sensitivity analysis for ICU LOS showed that excluding one study yielded a significant result (OR: 2.40; 95% CI: 1.29–3.50; P = 0.01). All studies had a moderate risk of bias. Conclusions: Hypernatremia in patients with TBI is associated with increased mortality. However, evidence for its impact on ICU and hospital LOS remains inconclusive. Further studies are warranted to better understand the prognostic implications of hypernatremia in this population.Ricardo Massoud; João Correia; Mariana Salles; Pedro Carvalho; Rafael Melo

Hypernatremia; Traumatic brain injury; MEDLINE; Resuscitation; Intensive care; Medicine; Intensive care medicine; Anesthesia; Emergency medicine

2026-03-01https://doi.org/10.1097/01.ccm.0001183916.50507.92Critical Care Medicine 20261Major approaches to parenteral nutrology therapy in the intensive care unit: a systematic reviewIntroduction: In the context of parenteral nutrition, critically ill patients are associated with a state of catabolic stress and a systemic inflammatory response. Patients admitted to intensive care units (ICU) have a prevalence of malnutrition greater than 35%. Objective: It was to carry out a systematic review to list the main approaches to macro and micronutrients in parenteral therapy in intensive care units. Methods: The PRISMA Platform systematic review rules were followed. The research was carried out from June to July 2025 in the Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: 115 articles were found. A total of 45 articles were evaluated and 25 were included in this systematic review. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 20 studies with a high risk of bias and 32 studies that did not meet GRADE. It was concluded that several clinical studies critically analyzed the evolution and changes that marked the development of parenteral nutrition in intensive care units. Standard solutions of crystalline amino acids, although devoid of side effects, remain incomplete about their composition (e.g., glutamine). Lipid emulsions have evolved a lot and are now included in bi- and tri-compartmented feeding bags, allowing true total parenteral nutrition, as long as daily micronutrients are prescribed. The question of exact individual energy, macro and micronutrient needs has not yet been resolved. Many complications attributed to total parenteral nutrition are the consequence of under- or overfeeding. The historical concept of hyperalimentation is the main cause, along with the use of fixed weight-based predictive equations (incorrect in 70% of critically ill patients).Pablo Wanglon Richter; Cristiano Villanova Andrade; Fernanda Assis Vianello Alvim; Francisco Alfredo Sampaio Cruz; Glauce Lippi de Oliveira; Isabele Helaine Rabelo Dias; Cristina Moraes Osório Leite; Leonardo Vieira de Lima; Vaneska Carvalho Bezerra de Brito; Fausto Rohnelt Durante

Intensive care; Parenteral nutrition; Context (archaeology); Micronutrient; Critically ill; Systematic review; Malnutrition; MEDLINE; Medicine; Intensive care medicine; Risk assessment; Cochrane Library; Enteral administration; Clinical nutrition

2026-03-23https://doi.org/10.54448/ijn26s201International Journal of Nutrology 20261Vitamin E in the management of oral mucositis: Systematic review with meta-analysis of randomized clinical trialsThis review aims to evaluate the efficacy of vitamin E in the treatment of oral mucositis (OM). This review was conducted in accordance with Reporting Items for Systematic Reviews and Meta-analyses and registered in the International Prospective Register of Systematic Reviews (PROSPERO). The search was conducted in seven databases and in the Brazilian repository of Theses and Dissertations of CAPES, consulted as a complementary source identifying clinical trials that evaluated the use of vitamin E alone in cancer patients for the treatment of OM. The risk of bias was assessed using the Joanna Briggs Institute tool. The data were extracted and systematized in a meta-analysis using a fixed-effect model in RStudio software. Fourteen articles were included, which evaluated 715 patients, with 330 patients in the intervention group and 385 in the control group. Among the included studies, 64.3% (n = 9) showed a significant reduction in the incidence of severe OM with the use of vitamin E (p < 0.05). The risk of bias assessment indicated low methodological risk, with 65% (n = 9) classified as low overall risk. The meta-analysis showed a lower incidence of severe mucositis (grades 3-4) in the vitamin E group compared to controls (RR: 0.37; 95% CI: 0.25-0.57), with a consistent effect in pediatric (RR: 0.14; 95% CI: 0.05-0.35) and non-pediatric (RR: 0.57; 95% CI: 0.35-0.92) populations. The results suggest a potential benefit of vitamin E in the management of OM induced by antineoplastic therapies, especially in reducing the incidence of more severe forms of this condition.Deysimara de Cássia Santos; Larissa Torres Fernandes; Danielle Negri Ferreira Neves; Sibele Nascimento de Aquino; Gisele Queiroz Carvalho

Randomized controlled trial; Vitamin E; Clinical trial; MEDLINE; Systematic review; Medicine; Internal medicine

2026-03-25https://doi.org/10.1016/j.oraloncology.2026.107945Oral Oncology 20261Non-Intrusive Data-driven Surrogate Models for Predicting Turbidity Currents Deposition from 3D SimulationsNon-intrusive data-driven methodologies, such as POD-DL, offer a powerful approach for constructing surrogate models to address complex parametric problems. POD-DL integrates deep neural networks and follows a multi-step dimensionality reduction process, beginning with a linear reduction via Proper Orthogonal Decomposition (POD) and followed by a nonlinear reduction using a deep autoencoder. A subsequent nonlinear regression, implemented with a forward neural network, accounts for temporal and parametric coefficients. The framework involves numerous hyperparameters, including the number of POD basis modes, network architecture specifications, and typical neural network parameters like learning rate and batch size, all of which influence both training time and model accuracy. In a previous work, we applied this scheme to study gravity currents under the 2D lock-exchange configuration [3] for multiple angles of the initial configuration [4]. The angle of the channel served as a parameter, i.e., different angles generated different dynamics that were learned by the surrogate model. The regression neural network could then predict the dynamics for unseen angles. Now, we extend the methodology to more realistic scenarios, a 3D channel-basin configuration for gravity currents, adapted from [5], analyzing variations in inlet velocities and sediment concentrations. Synthetic data were generated through large-scale parallel finite element simulations, allowing POD-DL to predict deposition maps for unseen parameter values. [1] M. Cracco et al., “Deep learning-based reduced-order methods for fast transient dynamics”, Arxiv Preprint 2212.07737, 2022. [2] S. Fresca and A. Manzoni, “POD-DL-ROM: Enhancing deep learning-based reduced order models for nonlinear parametrized PDEs by proper orthogonal decomposition”, Comput. Methods Appl. Mech. Engrg., 2022. [3] V. K. Birman, B. A. Battandier, E. Meiburg, and P. F. Linden, “Lock-exchange flows in sloping channels”, Journal of Fluid Mechanics, 577:53–77, 2007. [4] R. M. Velho, A. M. Cortes, G. F. Barros, F. A. Rochinha, and A. L. G. A. Coutinho, Advances in Data-Driven Reduced Order Models Using Two-Stage Dimension Reduction for Coupled Viscous Flow and Transport. Finite Elements in Analysis and Design, vol. 248, 2025. [5] T. Spychala, J. T. Eggenhuisen, M. Tilston and F. Pohl,The influence of basin setting and turbidity current properties on the dimensions of submarine lobe elements, SEDIMENTOLOGY, 2020.Roberto Machado Velho; Adriano M. Cortes; Gabriel M. Guerra; José Camata; Renato N. Elias; Alvaro L. G. A. Coutinho; Fernando A. Rochinha; Tiago H. F. Jesus; Thais C. A. Empinotti; Paulo L. B. Paraizo

Nonlinear system; Artificial neural network; Parametric statistics; Dimensionality reduction; Reduction (mathematics); Surrogate model; Model order reduction; Control theory (sociology); Surrogate data; Algorithm; Computer science; Artificial intelligence; Nonlinear regression; Applied mathematics; Deposition (geology); Parametric model; Curse of dimensionality; Feature (linguistics); Transient (computer programming); Deep learning; Basis (linear algebra)

2026-03-18https://doi.org/10.55592/cilamce2025.v5i.14509Anais do ... Congresso Ibero-Latino-Americano de Métodos Computacionais em Engenharia 20261Morphometric Mapping of Mandibular Incisor Root Canals and Its Implications for Instrument Size-taper SelectionINTRODUCTION: This study aimed to characterize the morphology of mandibular incisor root canals and to evaluate their correspondence with commonly used nickel-titanium (NiTi) instruments. METHODS: One hundred extracted human mandibular incisors were scanned using high-resolution micro-computed tomography. Minor and major canal diameters and aspect ratios were measured at 1-mm intervals from the apical foramen to 10 mm coronally. Canal cross-sections were classified as round, long-oval, or flat based on aspect ratio. A supplementary analysis determined the percentage frequency of canals with diameters equal to or smaller than a wide range of size-taper combinations of constant-taper NiTi instruments. An 80% frequency threshold was applied to identify meaningful correspondence between canal dimensions and instrument sizes. Descriptive statistics were calculated, and the association between major and minor diameters was assessed using Pearson's correlation coefficient. RESULTS: Both minor and major canal diameters increased progressively in the coronal direction, although enlargement of the major diameter was more pronounced from the middle third coronally. Round canals predominated in the apical region, whereas long-oval canals were most prevalent in the middle and coronal thirds; flat canals occurred mainly between 6 and 7 mm from the apex. Correspondence between NiTi instruments and the minor canal diameter depended strongly on instrument taper, with larger tapers required for smaller tip sizes to reach the 80% threshold. In contrast, correspondence with the major canal diameter was markedly limited across all instrument sizes and tapers, with no instrument achieving ≥80% correspondence along the entire root length. The correlation between minor and major canal diameters was weak, indicating disproportionate enlargement of canal dimensions. CONCLUSIONS: Mandibular incisors present pronounced anatomical asymmetry, particularly in the middle and coronal thirds, resulting in limited correspondence between conventional NiTi instruments and the major canal diameter.Carolina Oliveira de Lima; Emmanuel João Nogueira Leal Silva; Laís Vieira Maciel; Júlia de Brito Montan; Ana Flávia Almeida Barbosa; Marco Aurélio Versiani

Mandibular incisor; Selection (genetic algorithm); Root (linguistics); Incisor; Tooth root; Mandibular lateral incisor; Orthodontics; Lateral incisor; Biology; Mandibular canine; Dentistry; Medicine

2026-03-24https://doi.org/10.1016/j.joen.2026.03.009Journal of Endodontics 20261The influence of cement thickness on the bond strength of fiberglass posts: a systematic reviewThis review followed PRISMA guidelines and was registered on the Open Science Framework. A systematic search of five electronic databases (PubMed, Scopus, Web of Science, BVS, Embase) was conducted up to May 2025. Laboratory studies comparing bond strength of fiber posts with different resin cement layer thicknesses were included. Study selection, data extraction, and risk of bias assessment (using the RoBDEMAT tool) were performed by independent reviewers. From 284 initially identified records, 12 studies met the inclusion criteria. The analysis revealed that most studies (10 out of 12) indicated that thicker resin cement layers are associated with reduced bond strength, primarily due to increased polymerization shrinkage stress and potential for voids. However, some studies suggested that an excessively thin layer might also be detrimental, and two studies found no significant influence. The choice of adhesive system significantly affected the outcomes, with self-etch systems generally demonstrating lower bond strength values compared to etch-and-rinse systems. Resin cement layer thickness plays a significant role in the bond strength of fiber posts. While excessively thick layers generally compromise adhesion, extremely thin layers may also be insufficient.Clinical relevanceProper post space preparation and appropriate post selection are crucial for controlling cement layer thickness. Clinicians should avoid excessive post space during cementation, as this may compromise the bond strength of fiber posts. Therefore, priority should be given to achieving optimal adaptation between the fiber post and the root canal or to using relining techniques to reduce cement layer thickness and improve bond strength.Jean Soares Miranda; Carolina Oliveira de Lima; Izabela da Costa; Cleidiel Aparecido Araújo Lemos

Bond strength; Cement; Ultimate tensile strength; Bond; Deformation (meteorology); Bonding strength; Materials science; Composite material

2026-03-23https://doi.org/10.1080/00218464.2026.2648006The Journal of Adhesion 20261Erratum: The environmental impact, carbon emissions and sustainability of computing in the ATLAS experimentContains fulltext : 331205.pdf (Publisher’s version ) (Open Access)G. Aad; E. Aakvaag; B. Abbott; S. Abdelhameed; K. Abeling; N. J. Abicht; S. H. Abidi; M. Aboelela; A. Aboulhorma; H. Abramowicz; Y. Abulaiti; B. S. Acharya; A. Ackermann; C. Adam Bourdarios; L. Adamczyk; S. V. Addepalli; M. J. Addison; J. Adelman; A. Adiguzel; T. Adye; A. A. Affolder; Y. Afik; M. N. Agaras; A. Aggarwal; C. Agheorghiesei; F. Ahmadov; S. Ahuja; X. Ai; G. Aielli; A. Aikot; M. Ait Tamlihat; B. Aitbenchikh; M. Akbiyik; T. P. A. Åkesson; A. V. Akimov; D. Akiyama; N. N. Akolkar; S. Aktas; G. L. Alberghi; J. Albert; U. Alberti; P. Albicocco; G. L. Albouy; S. Alderweireldt; Z. L. Alegria; M. Aleksa; I. N. Aleksandrov; C. Alexa; T. Alexopoulos; F. Alfonsi; M. Algren; M. Alhroob; B. Ali; H. M. J. Ali; S. Ali; S. W. Alibocus; M. Aliev; G. Alimonti; W. Alkakhi; C. Allaire; B. M. M. Allbrooke; J. S. Allen; J. F. Allen; P. P. Allport; A. Aloisio; F. Alonso; C. Alpigiani; Z. M. K. Alsolami; A. Alvarez Fernandez; M. Alves Cardoso; M. G. Alviggi; M. Aly; Y. Amaral Coutinho; A. Ambler; C. Amelung; M. Amerl; C. G. Ames; T. Amezza; D. Amidei; B. Amini; K. Amirie; A. Amirkhanov; S. P. Amor Dos Santos; K. R. Amos; D. Amperiadou; S. An; C. Anastopoulos; T. Andeen; J. K. Anders; A. C. Anderson; A. Andreazza; S. Angelidakis; A. Angerami; A. V. Anisenkov; A. Annovi; C. Antel; E. Antipov; M. Antonelli; F. Anulli; M. Aoki

Sustainability; Greenhouse gas; Atlas (anatomy); Climate change; Sustainable development; Global warming; Environmental science

2026-03-24https://doi.org/10.1140/epjc/s10052-026-15357-0The European Physical Journal C 20261SEGURANÇA TRANSLACIONAL DA POLILAMININA EM TERAPIAS REGENERATIVAS DA MEDULA ESPINHAL: REVISÃO DE ESCOPOOBJETIVO: Mapear e analisar as evidências científicas acerca da segurança e dos eventos adversos associados ao uso da polilaminina em terapias regenerativas da medula espinhal. MÉTODOS: Revisão de escopo desenvolvida em 2026, conduzida conforme as diretrizes do Joanna Briggs Institute e recomendações PRISMA. Utilizou-se o mnemônico PCC, considerando: população (indivíduos ou modelos experimentais submetidos a terapias regenerativas medulares), conceito (segurança terapêutica e eventos adversos relacionados à polilaminina) e contexto (intervenções regenerativas aplicadas à lesão medular). A pergunta norteadora foi: “Quais evidências científicas sobre a segurança e eventos adversos associados ao uso da polilaminina em terapias regenerativas da medula espinhal?”. As buscas foram realizadas nas bases PubMed, Medline, Scopus, Embase e Cochrane Library, além da literatura cinzenta no Google Acadêmico. Incluíram-se estudos completos, de acesso livre, publicados nos últimos cinco anos, em todos os idiomas, que avaliassem segurança, biocompatibilidade ou eventos adversos relacionados à polilaminina. Excluíram-se estudos sem avaliação de segurança ou que não utilizassem o biomaterial como componente terapêutico central. RESULTADOS E DISCUSSÃO: Foram incluídos 11 estudos, abrangendo investigações experimentais, translacionais e clínicas iniciais. As evidências demonstraram perfil preliminar de segurança favorável da polilaminina, caracterizado por ausência de toxicidade sistêmica, baixa citotoxicidade e resposta inflamatória local controlada. Eventos adversos observados estiveram predominantemente associados ao trauma primário e não ao biomaterial implantado. Estudos pré-clínicos evidenciaram elevada biocompatibilidade e estabilidade tecidual, enquanto registros clínicos e autorizações regulatórias indicam avanço translacional para avaliação em humanos. Persistem, contudo, lacunas relacionadas à segurança imunológica de longo prazo, padronização das formulações e monitorização integrada de desfechos histológicos, funcionais e moleculares. CONCLUSÃO: A polilaminina apresenta perfil inicial promissor de segurança em terapias regenerativas da medula espinhal, sustentando sua progressão para ensaios clínicos controlados. Entretanto, a consolidação de sua aplicabilidade terapêutica depende de estudos multicêntricos com seguimento prolongado e definição padronizada de eventos adversos.Carolina Sena Vieira; Sadi Antonio Pezzi Junior; Elisabete Soares de Santana; Carolina da Silva Bachini; Kelly Denise Machado Motter; Enzo Rocha de Mattos; Vinicius Moreira de Souza; Gebes Vanderlei Parente Santos; Saulo Alves Silva; Daniel Nogueira Mendes Braga; Samuel Ferreira Silva; Gabriel Botti de Moura; Gabriel Alves Barbosa; Suelen da Silva Fernandes; Lorena Lemos de Castro Barbosa

Adverse effect; Context (archaeology); Chemical technology; MEDLINE; Public health; Medicine; Gynecology

2026-03-24https://doi.org/10.18623/rvd.v23.5529Veredas do Direito Direito Ambiental e Desenvolvimento Sustentável 20261Urinary metabolomics profile in children with ureteropelvic junction obstructionLucas Henrique Ferreira da Silva; Marcos Figueiredo Mello; Felipe Guilherme Hamoy Kataoka; Umberto Fauze Amsei Filho; Joao Pedro Simon Farah; Lydia Fumiko Yamaguchi; Massuo Jorge Kato; Marcone Augusto Leal de Oliveira; Andréa Tedesco Faccio; Lucia Andrade; Francisco Tibor Dénes; Roberto Iglesias Lopes; Marina Franco Maggi Tavares

Asymptomatic; Hydronephrosis; Urinary system; Ureteropelvic junction; Metabolomics; Urine; Multicystic dysplastic kidney; Kidney disease; Kidney; Medicine; Urology; Univariate analysis; Multivariate analysis; Biomarker; Internal medicine; Clinical significance; Gastroenterology; Disease

2026-03-24https://doi.org/10.21203/rs.3.rs-9107811/v1Research Square 20261PLN e Responsabilidade Social Aplicações da FrameNet-BrGamonal, Maucha; Vicente Dutra, Lívia; de Carvalho Pinto, Mariane; Torrent, Tiago

Government (linguistics); Context (archaeology); Production (economics); Agency (philosophy); Political science; Economics; Business

2026-04-13https://brasileiraspln.ufscar.br/livro-pln-4ed-vol3/aplicacoes-e-dominios/cap-framenetbr/cap-framenetbr.pdfOpen MIND 20261PLN e Responsabilidade Social Aplicações da FrameNet-BrGamonal, Maucha; Vicente Dutra, Lívia; de Carvalho Pinto, Mariane; Torrent, Tiago

Government (linguistics); Context (archaeology); Production (economics); Agency (philosophy); Political science; Economics; Business

2026-04-13https://doi.org/10.5281/zenodo.19202043Zenodo (CERN European Organization for Nuclear Research) 20261Diet quality and functional nutritional assessment in children and adolescents with cancerIntroduction Malnutrition and changes in body composition are common in pediatric cancer patients and are often underestimated during outpatient care. Simple anthropometric tools and functional assessments may enhance nutritional screening and clinical monitoring in this population. This study aims to investigate the relationship between anthropometric indicators, handgrip strength (HGS), and dietary intake in children and adolescents undergoing cancer treatment, compared to healthy peers. Methods A cross-sectional study was conducted with 45 participants (15 cancer patients and 30 age- and sex-matched controls). Assessments included arm and calf circumferences, tricipital skinfold, arm muscle circumference, HGS via dynamometry, and a 3-day dietary record classified using the NOVA system. Results The cancer group reported significantly lower consumption of ultra-processed foods compared to controls ( p = 0.039). Anthropometric indicators and HGS were significantly lower in the cancer group ( p < 0.05). A strong positive correlation was found between HGS and calf circumference (r > 0.80). In the total sample, 42.2% were eutrophic, while 51.1% were classified as overweight or obese. Conclusion HGS and basic anthropometric measurements may serve as supportive tools for early identification of nutritional risk. Integrating these indicators into routine outpatient care may support targeted interventions and promote dietary quality in children with chronic illnesses.Priscilla Faria Goretti; Raiane Marques Barbosa; Anke Bergmann; Leonardo Barbosa Almeida; Érica Cesário Defilipo; Paula Silva de Carvalho Chagas

Anthropometry; Overweight; Cancer; Outpatient clinic; Quality of life (healthcare); Psychological intervention; Body mass index; Food group; Medicine; Physical therapy; Environmental health; Food intake; Pediatrics; Physical activity; Activities of daily living

2026-03-24https://doi.org/10.1177/02601060261434838Nutrition and Health 20261Association Between Parental Cocaine Use and Sudden Infant Death Syndrome: A Systematic ReviewIntroduction: Sudden infant death syndrome (SIDS) is defined as the unexpected death of an infant under one year of age with no clear cause, typically occurring during sleep, and associated with various environmental risk factors. International recommendations for SIDS prevention include avoiding drug use, but the specific role of cocaine in increasing the risk of the syndrome is not well established. This is a systematic review of the literature on the association between parental cocaine use and the occurrence of SIDS. Objective: To conduct a systematic review of the literature on the association between parental cocaine use and the occurrence of SIDS. Material and Methods: The databases searched included PubMed/MEDLINE, Embase, Scopus, Web of Science, and LILACS, from their inception to December 2024. Study selection was conducted independently by two researchers, and disagreements were resolved by a third author. This review was registered in PROSPERO (CRD42024591448). Results: Eleven studies were included, all conducted in developed countries. A statistical analysis specifically correlating SIDS with cocaine use was available in seven studies, and in four of them, the results suggested an association between exposure and outcome. However, there were limitations related to the lack of data on the frequency, route, and intensity of drug use, with variation among studies in how this exposure was assessed. Conclusion: The studies analyzed in this systematic review suggest a possible association between cocaine use and the risk of SIDS. However, further research is needed to explore mechanisms related to maternal and paternal drug use during pregnancy and the postpartum period in order to establish a more accurate correlation with SIDS.Sofia Holetz de Toledo Lourenço; João Vítor Micherif Gudziki Tôrres; Patrícia Cristina Gomes Pinto; Sabrine Teixeira Ferraz Grünewald

Sudden infant death syndrome; Association (psychology); Cocaine use; Pregnancy; Systematic review; Meta-analysis; Postpartum period; Medicine; Psychiatry; Drug; Statistical analysis; MEDLINE; Sudden death; Pediatrics

2026-03-01https://doaj.org/article/8839c6f16ba04af18682cf8bfca88e1bDOAJ (DOAJ: Directory of Open Access Journals) 20261Tecnologias digitais e metodologias ativas no ensino de matemáticaFrancisco Evilasio de Sousa; J. M. G. de Oliveira; Thiago de Souza Pinto; Joselaine Freitas Silva; Júlio Cesar Santos Pereira; Rodolfo Cláudio da Cruz; FABRICIO MACEDO FERNANDES; Brendo Graunke Prates; Bianca Blandino Florentino; André do Carmo Albuquerque; Regina Célia de Aquino; Anderson Carlos Santos Morais; Oscar Ferreira da Silva Netto; Vanda Cristina Araújo Guimarães; Joyce Almeida Ataíde Alves

Perspective (graphical); Context (archaeology); Subject (documents); Set (abstract data type); Order (exchange)

2026-03-24https://doi.org/10.5281/zenodo.19224728Zenodo (CERN European Organization for Nuclear Research) 20261An Integrated Methodology for Assessing Wind Power Curtailment Using Anemometric Measurements and Operational Data in the Brazilian ContextThe increasing share of wind power generation has intensified the occurrence of curtailment events in power systems worldwide, mainly driven by transmission constraints, operational limitations, and imbalances between generation and demand. In the Brazilian context, this phenomenon has become more pronounced since 2023, highlighting structural challenges of the Brazilian Interconnected Power System and the need for reliable methodologies to estimate curtailed wind generation. This study presents a methodology to estimate wind power potential during curtailment events, aiming to support forecasting models and the economic compensation of affected generating agents. The proposed approach integrates measured power generation data, technical information of wind farms, and anemometric measurements from SCADA systems, combining data filtering and consistency procedures, gap-filling based on spatial correlation among wind farms, and regression models supported by statistical and computational techniques for wind-to-power conversion. The methodology was applied to more than 1000 wind farms connected to the Brazilian transmission grid and achieved accuracy levels above 95% on a semi-hourly basis and exceeding 99% for annual aggregations.Paulo S.C. Nascimento; William Cossich; Laís F. Araújo; Isabela Santos; Kevin Almeida; André Marcato

Wind power; Context (archaeology); SCADA; Electric power system; Consistency (knowledge bases); Grid; Wind power forecasting; Electricity generation; Computer science; Reliability engineering; Environmental science; Wind speed; Transmission (telecommunications); Power transmission; Economic dispatch; Power (physics); Meteorology; Renewable energy

2026-03-25https://doi.org/10.3390/atmos17040333Atmosphere 20261Reflexões sobre a liberdade em HusserlO intuito deste trabalho é apresentar uma interpretação a respeito do tema da liberdade na dimensão intersubjetiva e ética na fenomenologia de Edmund Husserl. Para tanto, discute-se inicialmente as influências da modernidade, identificando relações com os conceitos de liberdade de G.W. Leibniz e Immanuel Kant. Estas conexões são identificadas na forma de quatro elementos conceituais da liberdade, a inteligência, a espontaneidade, a contingência e a autonomia. Feitas tais relações, no âmbito da intersubjetividade, é proposto que o ato da empatia é permeado pela liberdade no momento em que o sujeito decide abrir-se para o outro, ou não, permitindo uma relação mais próxima entre os sujeitos. No campo da ética, a liberdade é entendida como necessária para a renovação do sujeito e da comunidade, no exercício de sua capacidade de autodeterminação, e assim ser possível a superação da crise diagnosticada por Husserl.Nathalie Barbosa de La Cadena; Victor Henrique Monteiro Alves

Subject (documents); Action (physics); Impossibility; Order (exchange); Work (physics); Field (mathematics); Philosophy

2026-03-17https://doi.org/10.25244/1984-5561.2025.7576Trilhas Filosóficas 20261Rede de suporte social de pessoas idosas em programas de atividade físicaObjetivo: Analisar a relação entre a participação em grupos de atividade física e a rede de suporte social de pessoas idosas. Métodos: Trata-se de um estudo observacional, transversal e quanti-qualitativo, realizado no ano de 2024, com pessoas idosas participantes de grupos de atividade física. Participaram do estudo 25 pessoas idosas (71,0 ± 5,1 anos de idade), sendo 80% mulheres, as quais responderam um questionário sociodemográfico, participaram de uma entrevista semiestruturada sobre o funcionamento do programa de atividade física, sobre os benefícios e motivos de participação, foram avaliados pelo Diagrama de Escolta, para avaliação da estrutura e função da rede de suporte social. Resultados: Em torno de 38% da rede de suporte social dos participantes eram membros do grupo de atividade física, sendo em média três membros para cada participante. Em torno de 90% dos vínculos da rede dos membros do grupo são de amizade. A categoria “construção e fortalecimento de vínculos” foi citada como principal motivação de participação e benefícios do programa (60%). Os participantes do programa de atividade física foram citados nos três níveis da rede de suporte social estabelecidos pelo Diagrama de Escolta, sendo 28,1%, 33,3% e 66,7% no primeiro, segundo e terceiro nível, respectivamente. Em torno de 10% citaram como contato de emergência os participantes do grupo e 5% o professor do programa. Conclusão: A estrutura e função de rede de suporte social de participantes de atividade física contam significativamente com membros do grupo em relação à quantidade e qualidade das relações e de apoio.Elisabeth Fernandes; Letícia Fernanda Belo; Andressa Crystine da Silva Sobrinho; Layana Liss Schwenger; Amanda Cristina de Sá; Laura Thais Del Vecchio Sampaio; Luana Karoline Ferreira; Grace Angélica de Oliveira Gomes

Social support; Qualitative research; Social network (sociolinguistics); Social relation; Social group; Sociology; Humanities; Psychology

2026-03-25https://doi.org/10.12820/rbafs.31e0424Revista Brasileira de Atividade Física & Saúde 20261Laterality in Neotropical psittacids (Aves, Psittacidae): Evaluation of its relationships with temperament and social interactionsLaterality is defined as asymmetries in function or structure in seemingly bilateral structures. In parrots, it can be expressed for various behaviors, for example, the preference for using the monocular visual field of a specific eye or a specific foot for feeding, also known as footedness. The aim of this study was to check for laterality in three Psittacine species and examine its relationship with aspects of their temperament and sociability. We analyzed birds of the following species: Psittacara leucophtalmus (n=15) , Primolius maraca (n=12) , Pionius maximiliani (n=23) . To evaluate laterality, we used the following indicators: footedness, unipedal support while resting, and eye preferences through the monocular visual field during the tests of pebble and seed, novel object, and reaction to person. The pebble and seed test evaluate cognitive capacities and foraging skills of birds by encouraging them to discriminate seeds and pebbles of similar size and color. The temperament was evaluated according to the birds’ individual responses to novel objects and reaction to person tests. Laterality indexes (LI) were calculated based on the frequency of use of each foot and eye, using the equation LI= (L-R)/(L+R), where L represent the left side use and R represents the right. Spearman correlation coefficients were calculated to assess the relationships between laterality and the behavioral aspects investigated (temperament and social behavior). The results indicated the presence of laterality in the three bird species, highlighting the right eye preference and no predominant direction was found for footedness and unipedal support. Significant correlations between eye preference and the four temperament dimensions (activity, boldness, anxiety and proximity to humans) were found. Higher activity was related to greater ocular LI and LI in the pebble and seed test towards the right. Bolder and more anxious birds had lower LI in the human reaction test, thus right eye preferences. Avoidance to humans was related to lower LI in the novel object test, therefore, right eye preferences. No significant correlations were found between laterality and positive or negative social interactions. Our study contributes to the scientific literature by identifying laterality in neotropical species, a topic for which data remain limited. Additionally, it is the first study to demonstrate a relationship between temperament and laterality in psittacids, which could be explained by underlying connections between emotionality and cognition, as observed in other animal species. These hypotheses warrant further investigation in future research. • Laterality and its connections with temperament were investigated in Neotropical • Psittacids. • Laterality was assessed by analyzing foot and eye preferences and unipedal support. • Temperament dimensions were activity, boldness, anxiety, neophilia, and human proximity. • Right eye preference was related to boldness, anxiety, and avoidance to humans. • Laterality can guide more individualized welfare strategies for captive animals.Larissa Rodrigues Gomes; Gustavo Nunes de Almeida; Maria Eduarda Caçador Branco; Aline Cristina Sant’Anna

Laterality; Temperament; Social relation; Social relationship; Boldness; Psychology; Developmental psychology; Social psychology

2026-03-25https://doi.org/10.1016/j.applanim.2026.106993Applied Animal Behaviour Science 20261Materiais educativos desenvolvidos no contexto do Projeto de Vivência no Sistema Único de Saúde de Juiz de Fora-MG: pelo aumento das coberturas vacinaisEste conjunto de materiais educativos foi desenvolvido no contexto das Vivências e Estágios na Realidade do Sistema Único de Saúde (VER-SUS), realizadas em Juiz de Fora, Minas Gerais, com foco no fortalecimento das ações de imunização e no enfrentamento da queda das coberturas vacinais. A produção integra atividades de capacitação teórica, oficina prática e vivência no território, articulando fundamentos da vigilância epidemiológica, organização do Programa Nacional de Imunizações e análise crítica do cotidiano dos serviços de saúde. Os materiais abordam desde conceitos estruturantes da imunização e seus determinantes sociais até a aplicação prática na leitura de cartões de vacina e identificação de esquemas incompletos, com ênfase na qualificação do cuidado e no uso estratégico da informação em saúde. Ao mesmo tempo, refletem uma perspectiva formativa que valoriza a experiência no território, o diálogo com as equipes e a problematização das práticas, reconhecendo a vacinação como uma intervenção que ultrapassa o âmbito técnico e se insere nas dinâmicas sociais e institucionais do SUS. Trata-se, portanto, de um conjunto de produtos voltados à educação em saúde e à qualificação profissional, alinhados à defesa do SUS e à ampliação do acesso e da equidade nas ações de imunização.Cosme Rezende Laurindo

Context (archaeology); Politics; Intersection (aeronautics); Qualitative research; Power (physics); Humanities; Political science; Sociology

2026-03-25https://doi.org/10.5281/zenodo.19226360Zenodo (CERN European Organization for Nuclear Research) 20261Materiais educativos desenvolvidos no contexto do Projeto de Vivência no Sistema Único de Saúde de Juiz de Fora-MG: pelo aumento das coberturas vacinaisEste conjunto de materiais educativos foi desenvolvido no contexto das Vivências e Estágios na Realidade do Sistema Único de Saúde (VER-SUS), realizadas em Juiz de Fora, Minas Gerais, com foco no fortalecimento das ações de imunização e no enfrentamento da queda das coberturas vacinais. A produção integra atividades de capacitação teórica, oficina prática e vivência no território, articulando fundamentos da vigilância epidemiológica, organização do Programa Nacional de Imunizações e análise crítica do cotidiano dos serviços de saúde. Os materiais abordam desde conceitos estruturantes da imunização e seus determinantes sociais até a aplicação prática na leitura de cartões de vacina e identificação de esquemas incompletos, com ênfase na qualificação do cuidado e no uso estratégico da informação em saúde. Ao mesmo tempo, refletem uma perspectiva formativa que valoriza a experiência no território, o diálogo com as equipes e a problematização das práticas, reconhecendo a vacinação como uma intervenção que ultrapassa o âmbito técnico e se insere nas dinâmicas sociais e institucionais do SUS. Trata-se, portanto, de um conjunto de produtos voltados à educação em saúde e à qualificação profissional, alinhados à defesa do SUS e à ampliação do acesso e da equidade nas ações de imunização.Cosme Rezende Laurindo

Context (archaeology); Politics; Intersection (aeronautics); Qualitative research; Power (physics); Humanities; Political science; Sociology

2026-03-25https://doi.org/10.5281/zenodo.19226359Zenodo (CERN European Organization for Nuclear Research) 20261Comparative study of turbulence models in a subsonic educational wind tunnelThis study presents the design of an open-circuit, suction-type subsonic wind tunnel and a comparative evaluation of three turbulence models: Shear Stress Transport (SST) k-omega, Realizable k-epsilon, and Spalart-Allmaras. The main components of the wind tunnel, including the test section, diffuser, and contraction nozzle, were designed using a combined cubic profile for the contraction geometry. Empirical correlations were applied to estimate pressure losses throughout the system. The internal flow behavior was analyzed using computational fluid dynamics (CFD) simulations with the three turbulence models. The final design resulted in a wind tunnel with a total length of 6.36 m, a square test section with a side length of 0.56 m, and a design velocity of 63 m/s. Numerical results showed good agreement with analytical predictions, with deviations below 0.4% for the test section velocity and below 1.3% for the dynamic pressure at the test section inlet. Velocity contours, dynamic pressure distributions, and velocity profiles showed strong agreement among the turbulence models, indicating low sensitivity of the flow to the turbulence model under the studied conditions. Among the evaluated models, the Spalart-Allmaras model provided accuracy comparable to the others while requiring lower computational cost, making it the most suitable model for this type of analysis.Natália de Oliveira Faria; Julio Cesar Costa Campos; Charles Luís da Silva; Rogério Fernandes Brito; Antônio Marcos de Oliveira Siqueira; Henrique Márcio Pereira Rosa; Álvaro Messias Bigonha Tibiriçá; Washington Orlando Irrazabal Bohorquez

Turbulence; Wind tunnel; Computational fluid dynamics; K-epsilon turbulence model; Shear stress; Wind speed; K-omega turbulence model; Turbulence kinetic energy; Turbulence modeling; Aerodynamics; Mechanics; Subsonic and transonic wind tunnel; Dynamic pressure; Wind gradient; Physics; Supersonic wind tunnel; Wind shear; Flow (mathematics); Static pressure; Meteorology; Computer simulation; Shear velocity; Flow velocity

2026-03-25https://doi.org/10.18540/jcecvl12iss1pp23508The Journal of Engineering and Exact Sciences 20261Tecnologias digitais e metodologias ativas no ensino de matemáticaFrancisco Evilasio de Sousa; J. M. G. de Oliveira; Thiago de Souza Pinto; Joselaine Freitas Silva; Júlio Cesar Santos Pereira; Rodolfo Cláudio da Cruz; FABRICIO MACEDO FERNANDES; Brendo Graunke Prates; Bianca Blandino Florentino; André do Carmo Albuquerque; Regina Célia de Aquino; Anderson Carlos Santos Morais; Oscar Ferreira da Silva Netto; Vanda Cristina Araújo Guimarães; Joyce Almeida Ataíde Alves

Perspective (graphical); Context (archaeology); Subject (documents); Set (abstract data type); Order (exchange)

2026-03-24https://doi.org/10.5281/zenodo.19224727Zenodo (CERN European Organization for Nuclear Research) 20261TODOS VENCEM: UM OLHAR PARA A PARTICIPAÇÃO ESPORTIVA DE ATLETAS DO ATLETISMO PARALÍMPICO ESCOLARThe athletic development of young people with disabilities has shifted towards holistic approaches, such as Long-Term Athlete Development, which value physical literacy and global development. Paralympic athletics is a foundational sport and the most practiced modality in the Brazilian School Paralympics. Competitive sports participation is crucial for obtaining classification for athletes with disabilities, in addition to contributing to physical, psychological, and social well-being. Thus, this study aimed to describe the level of competitiveness, map the possible events, and quantify athlete participation in the School Selection (SEs) of school paralympic athletics in Brazil in 2025. To this end, a descriptive and quali-quantitative study was conducted, based on the documentary analysis of official competition bulletins from the Brazilian Paralympic Committee (CPB) for the 2025 state SEs. Data were tabulated and analyzed using descriptive statistics (absolute numbers and percentages). Low competitiveness was observed: 74.95% of the 2112 events had only one registered athlete, resulting in an automatic gold medal. Only 4.7% of the events had more than three participants. Of the over 1200 athletes, 76 (6.2%) did not obtain medals, predominantly those with intellectual disabilities. The results indicate low competitiveness and a significant gap in school paralympic sports participation. It is crucial to strengthen the sports culture by encouraging broad and early participation, aligned with the 'Sport for Life' philosophy, aiming at the integral development and inclusion of youth with disabilities in the national sports scene. Received: 2026/01/04 Reformulated: 2026/03/23 Accepted: 2026/03/24Renato de Carvalho Guerreiro; Carlos Makleyton Caetano Schuchter; Simara Regina de Oliveira Ribeiro; Aryelle Malheiros Caruzzo; Daniela Nascimento Lage; Gustavo Henrique Scarmigliat Cruz; Arthur Henrique Rodrigues Cordeiro; Marco Túlio de Mello; Andressa Silva

Athletes; Inclusion (mineral); Competition (biology); Descriptive statistics; State (computer science); Youth sports; Competitive sport; Psychology; Political science; Sociology; Pedagogy; Value (mathematics); Physical education

2026-03-26https://doi.org/10.36311/2674-8681.2026.v27n1.p103-122REVISTA DA ASSOCIAÇÃO BRASILEIRA DE ATIVIDADE MOTORA ADAPTADA 20261Targeting hypertension through natural phenolics: The multifaceted role of cinnamic acid and its derivativesHypertension is a serious global public health problem that significantly increases the risk of cardiovascular diseases. Its etiology involves inflammatory processes, oxidative stress, and imbalances in blood pressure (BP) regulatory systems. In this context, the search for new therapeutic agents remains a major challenge, highlighting natural compounds such as cinnamic acid (CA) and its derivatives, including caffeic acid (CAF) and ferulic acid (FA). This review aimed to investigate the antihypertensive, anti-inflammatory, and antioxidant potential of CA and its derivatives. The phenolic acids analyzed, particularly CA and FA, exhibited greater inhibitory activity on angiotensin-converting enzyme (ACE), whereas CAF showed lower activity. Furthermore, cinnamic acid and its derivatives increased nitric oxide (NO) production, contributing to vasodilation. Regarding the inflammatory response, studies on phenolic acids demonstrated a reduction in the pro-inflammatory cytokines IL-1β, IL-6, IL-8, and TNF-α, accompanied by an increase in the anti-inflammatory cytokine IL-10, indicating a relevant anti-inflammatory effect. Similarly, in the antioxidant system, increased levels of superoxide dismutase (SOD) and glutathione (GSH) were observed, along with a reduction in the pro-oxidant marker malondialdehyde (MDA). Additionally, the DPPH and ABTS assays demonstrated greater free radical scavenging activity for CA, CAF, and FA derivatives. Taken together, these findings suggest that phenolic acids are promising candidates for the treatment of hypertension due to their favorable safety profile, with CA standing out as the main compound with hypotensive effects.Samuel S. P. de Araujo; Brenda L. B. dos Santos; Waldilleny R. A. de Moura; Leonardo Guedes Rodrigues; Luiz G. S. Branco; Helio C. Salgado; Renato Nery Soriano; Marina de T. Durand; João Paulo J. Sabino

Cinnamic acid; Ferulic acid; Antioxidant; Caffeic acid; Nitric oxide; ABTS; Malondialdehyde; Superoxide dismutase; Chemistry; Biochemistry; Pharmacology; Oxidative stress; DPPH; Glutathione; Pro-oxidant; Enzyme

2026-03-26https://doi.org/10.1007/s00424-026-03163-2Pflügers Archiv - European Journal of Physiology 20261Os mistérios dos rituais tradicionais na literatura moçambicanaEste artigo analisa os mistérios ritualísticos africanos a partir da narrativa Mulungu (2007), do escritor moçambicano contemporâneo Adelino Timóteo, com o intuito de evidenciar a riqueza e diversidade cultural e da identidade das comunidades moçambicanas na medida em que se procura desconstruir a visão homogeneizada sobre a África. Nesse percurso, através da análise crítica da referida narrativa, exploram-se diversos ritos como os de fertilidade, iniciação, purificação e celebração, destacando a sua importância na configuração da vida social, da ancestralidade, das relações de poder e da corporalidade. A obra explora múltiplos significados simbólicos e culturais que o corpo carrega durante os atos performáticos dos rituais e se configura como um espaço de compreensão crítica da literatura moçambicana e das práticas ritualísticas africanas.Amosse Jorge Gelo; Tércia Costa Valverde

Identity (music); Narrative; Power (physics); Metropolitan area; Diversity (politics); Hegemony; Context (archaeology); Humanities; History; Sociology; Ethnic group

2026-03-18https://doi.org/10.17851/1982-0739.30.3.110-124Em Tese 20261Monitoramento da Integridade Estrutural de Vias Férreas a Partir de Medições de Vibração a Bordo Utilizando Técnicas de Aprendizado ProfundoA manutenção da infraestrutura ferroviária apresenta um constante desafio devido ao desgaste natural e aos danos decorrentes do uso contínuo, que podem comprometer a segurança e eficiência desse meio de transporte. Este estudo propõe o uso de Monitoramento de Integridade Estrutural (SHM, do inglês Structural Health Monitoring) através da aplicação de um Autocodificador Variacional (VAE, do inglês Variational Autoencoder) para a detecção de irregularidades em vias férreas. O VAE é treinado para aprender a representar o comportamento normal da via e, junto com a Carta de Controle Hotelling T², é capaz de detectar anomalias estruturais. A metodologia proposta inclui a otimização dos hiperparâmetros do VAE utilizando a biblioteca Optuna, buscando maximizar o desempenho do modelo. Os resultados indicam que a combinação do VAE com a Carta de Controle T² de Hotelling é eficaz na detecção de defeitos, oferecendo uma solução mais econômica e menos invasiva para a manutenção preventiva das vias. Embora o método ainda não quantifique as anomalias, ele apresenta um grande potencial para aprimorar a confiabilidade operacional.Renato Da Silva Melo; Marcos Rezende Spínola Neto Rezende Spínola Neto; Rafaelle Piazzaroli Finotti Amaral; Andreia Gomes Meixedo da Cunha; Diogo Rodrigo Ferreira Ribeiro; Flavio de Souza Barbosa; Alexandre Abrahão Cury

Operation planning; Statistical analysis; Physics; Humanities

2026-03-27https://doi.org/10.63595/vetor.v36i1.18345VETOR - Revista de Ciências Exatas e Engenharias 20261Monitoramento da Integridade Estrutural de Turbinas Eólicas Utilizando Autocodificadores EsparsosO monitoramento da integridade estrutural de torres eólicas é fundamental para garantir a segurança operacional e prolongar a vida útil dessas estruturas utilizadas na geração de energia renovável. As torres eólicas estão sujeitas a condições ambientais severas e a cargas dinâmicas significativas devido ao vento, podendo levar ao surgimento de danos. Dessa forma, o presente estudo explora a eficácia do uso de técnicas de aprendizado não supervisionado, mais especificamente os autocodificadores esparsos (SAE), para a detecção de danos estruturais em turbinas eólicas com base em sinais dinâmicos coletados durante operações de funcionamento simuladas em protótipos de pás de turbinas. O SAE é treinado utilizando dados de estruturas intactas e testado em cenários que incluem a introdução de fissuras e a adição de massas nas pás. Utilizando a Carta de Controle Hotelling T², os modelos demonstraram ser robustos para identificar corretamente tanto a adição de massa quanto a presença de fissuras, independentemente da velocidade da turbina. As análises mostram que o SAE é eficaz na extração de características relevantes dos dados e na detecção de alterações estruturais, com boa precisão e confiabilidade. Os resultados evidenciam que o SAE, combinado com a estatística T², oferece uma abordagem não supervisionada robusta para o monitoramento da integridade estrutural de turbinas eólicas, proporcionando uma ferramenta poderosa para a manutenção preditiva e a detecção precoce de danos.Mariana Passamai Alvarenga; Marcos Spínola Neto; Rodrigo Astroza; Rafaelle Piazzaroli Finotti; Flavio de Souza Barbosa; Alexandre Abrahão Cury

Water consumption; Population; Reinforced concrete; Physics; Humanities

2026-03-27https://doi.org/10.63595/vetor.v36i1.18355VETOR - Revista de Ciências Exatas e Engenharias 20261Lewis acid-catalyzed solvent-free multicomponent reactions: Synthesis and structural features of fused pyrrole-chromenesHerein, we report a Lewis acid-catalyzed three-component reaction between nitrochromenes, diketones, and aniline derivatives under solvent-free or greener conditions, affording a new series of fused pyrrole–chromene derivatives in excellent yields (80–98%). Detailed spectroscopic investigations, including variable-temperature NMR experiments, revealed dynamic conformational behavior associated with the N-phenyl moiety, accounting for the detected signal broadening. Additionally, ESI-MS analysis provided evidence for key intermediates, supporting a plausible reaction mechanism based on Lewis acid activation and in situ generation of NiO as the catalytic active species. This methodology offers a green and practical approach for the synthesis of fused heterocyclic systems with potential pharmacological relevance.Silmara L.G. Alves; Matheus V. Machado; Andreza M. Moraes; Leonã S. Flores; Charlane C. Corrêa; Jefferson L. Princival; José A.F.P. Villar

Lewis acids and bases; Yield (engineering); X-ray crystallography; Sequence (biology); Chemistry; Combinatorial chemistry

2026-03-27https://doi.org/10.1016/j.tet.2026.135270Tetrahedron 20261Diallel analysis of elephantgrass clones for bioenergy production in a tropical environmentAbstract Climate change caused by fossil fuels has driven the search for bioenergy sources. Elephantgrass [ Cenchrus purpureus (Schumach.) Morrone] biomass is a promising alternative for diversifying the energy matrix. One of the main steps of a genetic breeding program is the selection of parents who will form the crossing block, and the use of diallel analysis is critical in this step. Therefore, this study aimed to use mixed linear models to analyze diallel crosses and estimate the general combining ability (GCA) and specific combining ability (SCA) of elephantgrass clones to select superior parents and hybrids for bioenergetic applications. Eleven parents were crossed in a diallel scheme, totaling 55 hybrid combinations, and evaluated in a randomized complete block design with three replications. The measured traits were dry biomass production (DBP), in vitro dry matter digestibility (IVDMD), and cellulose‐lignin (C:L) ratio. There was a significant effect of SCA, SCA × cut interaction, and permanent effect on DBP, and a significant effect of GCA on IVDMD and C:L. There was a predominance of genes with additive effects controlling IVDMD and C:L traits, and dominance and epistasis for DBP. The parents selected for biochemical conversion processes were Embrapa's Active Germplasm Bank of Elephantgrass (BAGCE) 38 and CNPGL 92‐38‐2. The parents selected for direct combustion of biomass were BRS Canará, BRS Capiaçu, and CNPGL 96‐27‐3. The hybrids BAGCE 21 × BAGCE 38, BAGCE 30 × CNPGL‐92‐38‐2, and BAGCE 38 × BRS Kurumi show potential for the production of dry biomass.Tatiana de Vilela de Souza Pessoa; Érika de Fátima de dos Santos; Jailton da Costa Carneiro; Pedro Crescêncio Souza Carneiro; Kaio Olímpio das Graças Dias; Juarez Campolina Machado

Diallel cross; Hybrid; Germplasm; Dry matter; Heterosis; Bioenergy; Randomized block design; Biomass (ecology); Biology; Biotechnology; Agronomy; Genetic gain; Selection (genetic algorithm); Epistasis; Production (economics); Agriculture

2026-03-01https://doi.org/10.1002/csc2.70273Crop Science 20261Development and in vitro biological evaluation of chitosan films incorporating Plinia cauliflora leaf extractMariana Hauck Vianna; Júlia Bertolini Fajardo; Thayná Gomes Ferreira; Ari Sérgio de Oliveira Lemos; Thalita de Freitas Souza; Lara Melo Campos; Priscila de Lima Paula; Maria Clara Machado Resende Guedes; Elaine Soares Coimbra; Gilson Costa Macedo; Mariane Rocha Cordeiro Comitre; Ângelo M. L. Denadai; Thaís Nogueira Barradas; Rodrigo Luiz Fabri

Chitosan; Biopolymer; Antimicrobial; Biocompatible material; In vitro; Antioxidant; Fibroblast; Chemistry; Polymer; Food science; Matrix (chemical analysis); Natural polymers; Anti-inflammatory

2026-03-27https://doi.org/10.1016/j.jddst.2026.108281Journal of Drug Delivery Science and Technology 20261Editor's LetterEditor's letterJoão Vitor De Freitas Moreira; Alexandre Veronese

2026-03-27https://doi.org/10.19092/reed.v13.1128Revista de Estudos Empíricos em Direito

20261Carta dos Editorescarta dos editoresJoão Vitor De Freitas Moreira; Alexandre Veronese

2026-03-27https://doi.org/10.19092/reed.v13.1127Revista de Estudos Empíricos em Direito

20261Eficácia da simulação de alta e média fidelidade na educação em enfermagem: ensaio clínico randomizadoRESUMO Objetivos: comparar a eficácia da simulação clínica de alta e média fidelidade no desenvolvimento de conhecimentos e habilidades de estudantes de Enfermagem para avaliação e tratamento de lesões por pressão. Métodos: ensaio clínico randomizado, com cegamento do avaliador. Alocaram-se 32 estudantes em grupo experimental (n=17) e controle (n=15). A intervenção envolveu abordagem teórica, simulação de alta fidelidade (grupo experimental) e média fidelidade (grupo-controle). Coletaram-se os dados usando questionário sociodemográfico, teste teórico, checklist de habilidades e Escala de Avaliação do Debriefing. A análise dos dados incluiu qui-quadrado, Mann-Whitney, Anova e tamanho de efeito, com significância de 5%. Resultados: houve melhora significante no conhecimento teórico dos dois grupos (p<0,05). Os grupos não diferiram significantemente nas habilidades (p=0,853). A experiência com debriefing foi positiva e semelhante em ambos. Conclusões: a simulação melhorou o conhecimento e as habilidades, sem diferenças no grau de fidelidade da simulação.Franciane Silva Luiz; Isabel Cristina Gonçalves Leite; Luana Vieira Toledo; Kelli Borges dos Santos; André Luiz Silva Alvim; Roberta Teixeira Prado; Angélica da Conceição Oliveira Coelho; Fábio da Costa Carbogim

Checklist; Analysis of variance; Statistical significance; Repeated measures design; Randomized controlled trial; Test (biology); Debriefing; Psychology; Gerontology; Physical therapy; Medicine; Clinical psychology

2026-01-01https://doi.org/10.1590/0034-7167-2025-0134ptRevista Brasileira de Enfermagem 20261Construção e validação de vídeo educativo sobre higienização das mãos utilizando inteligência artificial: estudo metodológicoObjetivo: Construir e validar um vídeo educativo sobre higienização das mãos utilizando inteligência artificial. Métodos: Trata-se de um estudo metodológico realizado em três etapas: construção do vídeo, validação de conteúdo e análise da confiabilidade do roteiro. Foram selecionados 12 juízes especialistas para a validação do vídeo educativo e seis expertos para a análise da confiabilidade do roteiro. Para análise de dados, foi utilizado o índice de validade de conteúdo, o teste binomial e o coeficiente de correlação intraclasse. Resultados: O índice de validade de conteúdo variou de 0,83 a 1,00, demonstrando consenso entre os juízes especialistas, como evidenciado pelo teste binomial. Quanto à confiabilidade do roteiro, foi considerada boa, com um coeficiente de correlação intraclasse de 0,90 e valor p < 0,001. Considerações finais: Foi construído e validado um vídeo educativo sobre higienização das mãos utilizando inteligência artificial, visto que o conteúdo e o roteiro apresentaram valores satisfatórios.Poliana de Morais Santos; Flávia Cristina Rodrigues; Thiago César Nascimento; Kelli Borges dos Santos; Fábio da Costa Carbogim; André Luiz Silva Alvim

Reliability (semiconductor); Measure (data warehouse); Binomial distribution; Statistical analysis; Humanities; Mathematics; Physics; Computer science

2026-03-26https://doi.org/10.19175/recom.v16i0.5489Revista de Enfermagem do Centro-Oeste Mineiro 20261Infodemia en COVID-19 y su relación con estrés, depresión y ansiedad en personas mayoresObjetivo: analizar el fenómeno de infodemia en COVID-19 y su relación con estrés, depresión y ansiedad en personas mayores. Método: estudio cuantitativo, correlacional, transversal. Muestra no probabilística de 195 personas mayores, quienes respondieron cuestionario para: Infodemia, Escala de Estrés Percibido, Escala Depresión Geriátrica Yesavage, Escala de Ansiedad Generalizada, a través de encuesta telefónica y/o vía online autoadministrada. Previa aceptación de consentimiento informado. Se usó estadística descriptiva e inferencial para el análisis de datos. Estudio fue aprobado por Comité Ético. Resultados: la edad promedio fue de 69 ± 6,2 años, 58% fueron mujeres. El promedio de horas diarias destinadas a información fue de 5±2,5, siendo mayor en hombres, sin diferencias significativas entre sexos. Las horas de infodemia se relacionaron inversamente proporcional al padecimiento de salud mental, es así como a mayores horas de información, menor el nivel de estrés, depresión y ansiedad. Conclusión: infodemia no necesariamente tiene un impacto negativo en la salud mental de las personas mayores. Desde enfermería, se vuelve esencial fortalecer el pensamiento crítico, la alfabetización digital, promover redes de apoyo y espacios seguros que potencien la autonomía y afrontamiento ante la desinformación.Varinia Alejandra Rodríguez-Campo; Sandra Verónica Valenzuela-Suazo; Ricardo Bezerra-Cavalcante; Olivia Sanhueza-Alvarado; Patricia del Tránsito Jara Concha; Aldo Renato Vera-Calzaretta; Pablo Miguel Palma-Novoa

Persona; Anxiety; Mental health; Older people; Humanities; Psychology; Social psychology; Sociology

2026-01-01https://doi.org/10.1590/1518-8345.7769.4749Revista Latino-Americana de Enfermagem 20261Doomed to extinction by mining: a new species of Hoplocryptanthus (Bromeliaceae: Bromelioideae) from Congonhas, Minas Gerais, BrazilDe Castro, João Luís L. M.; Ribeiro, Otávio B. C.; Leme, Elton M. C.; De Almeida, Pedro S.; De Faria, Ana Paula G.

Extinction (optical mineralogy); Ectotherm; Population; Climate change; Geography; Ecology

2026-03-30https://doi.org/10.48580/dgx7kThe Catalogue of Life 20261O Uso do PIX por Empresas Privadas no Brasil: Impactos, Desafios e PerspectivasA implementação do PIX, sistema de pagamentos instantâneos do Banco Central do Brasil, transformou a dinâmica das transações financeiras no setor empresarial. Este estudo analisa, com base em dados secundários, a incorporação do PIX por empresas privadas brasileiras em suas operações entre 2020 e 2023, com ênfase na potencial redução de custos operacionais, na gestão do fluxo de caixa e na eficiência nas rotinas financeiras. Metodologicamente, trata-se de uma pesquisa qualitativa, de caráter descritivo, baseada em revisão de literatura e análise documental de relatórios e estatísticas oficiais sobre meios de pagamento. Os resultados indicam que o PIX favoreceu a redução do tempo de liquidação financeira, ampliou a competitividade no varejo e estimulou a digitalização de pequenos negócios, especialmente de micro e pequenas empresas. Como desafios, destacam-se demandas por atualização tecnológica, necessidade de adaptação a normas de segurança e ajustes nos processos internos de conciliação e controle fiscal. Conclui-se que o PIX se consolidou como infraestrutura estratégica para o ambiente de negócios no Brasil, com tendência de expansão via novas funcionalidades, como PIX Automático e integrações ao Open Finance.Tiago de Almeida Santos Tergilene; Marcelo Dos Santos da Silva; Gustavo Joaquim Lisboa; Priscila De Queiroz Leal

Work (physics); Context (archaeology); Product (mathematics); Service (business); Subject (documents); Control (management); Political science; Business

2026-03-30https://doi.org/10.22279/navus.v18.2195Navus - Revista de Gestão e Tecnologia 20261Surgical induction model of femoral defect in Wistar rats for bone repair histologyThe creation of bone lesions using a well-established surgical technique is essential for obtaining histological images in experimental models that aim to study the pathophysiology of bone repair. In this study, we report the steps of a surgical method to induce bone defects in Wistar rats, providing a basis for experimental studies requiring precision in these lesions, especially for future experimental tests and subsequent histological analysis. The animal model remains an important alternative for investigating the inflammatory process and bone regeneration. The model consists of creating experimental, non-critical surgical bone defects in the femurs of Wistar rats (Rattus norvegicus, 90 days old, weighing between 250-300 g) using a 2-mm spherical drill and a low-speed motor. The present report includes reproducible information on the selection of the animals and the materials needed to perform anesthesia and surgery to induce bone defects. It also provides details on post-surgical care, sample collection, and preparation of samples for histological processing. The steps presented here can significantly increase the accuracy of lesion creation and allow for more precise results in the analysis of bone architecture and repair.F.L.D. de Oliveira; A.C. Nagato; T.N. França; F.M. Aarestrup; BJV Aarestrup

Histology; Animal model; Experimental animal; Lesion; Bone healing; Rat model; Surgical procedures; Process (computing); Medicine; Surgery; Pathology; Femoral bone

2026-01-01https://doi.org/10.1590/1414-431x2025e15168Brazilian Journal of Medical and Biological Research 20261Basics of Intraocular PharmacotherapyGustavo Barreto Melo; Emmerson Badaró

Pharmacotherapy; Intraocular pressure; Drug delivery; Macular degeneration; Clinical trial; Drug; Dosing; Medicine; Intensive care medicine; Ophthalmology

2026-01-01https://doi.org/10.1007/978-3-031-29358-0_17-1 20261Palatal Ulceration Associated with Ecstasy Consumption: An Emerging Clinical AlertAbstract Oral ulcerations associated with ecstasy (3,4-methylenedioxymethamphetamine - MDMA) use are extremely rare, with only three cases reported in the literature to date. A 25-year-old man presented with palatal pain upon awakening following a night of recreational activity. Initial examination revealed a small, centrally located erythematous plaque with a friable surface on the soft palate. Within 12 h, the lesion progressed to a painful ulceration with irregular margins and a white pseudomembrane. Detailed history-taking revealed recent ecstasy use, with the tablet retained in the oral cavity prior to swallowing. Based on clinical findings and patient history, a diagnosis of chemical burn related to ecstasy was established. Treatment consisted of low-level laser therapy, combined with topical antiseptic gel. Complete clinical resolution was observed within five days. The stigma surrounding illicit drug use frequently leads to underreporting or delayed disclosure, which may complicate diagnosis and management.Yuri de Lima Medeiros; Luan Viana Faria; Daniel Amaral Alves Marlière; Letícia Drumond de Abreu Guimarães; Matheus Furtado de Carvalho

Ecstasy; Chlorhexidine; Recreational Drug; Lesion; Discontinuation; Physical examination; Medicine; Dermatology; Otorhinolaryngology; Dentistry; Oral cavity; Surgery

2026-03-30https://doi.org/10.1007/s12070-026-06533-5Indian Journal of Otolaryngology and Head & Neck Surgery 20261Effectiveness of highand medium-fidelity simulation in nursing education: randomized controlled trialOBJECTIVES: to compare the effectiveness of highand medium-fidelity clinical simulation on nursing students' knowledge and clinical skills for pressure injury assessment and treatment. METHODS: assessor-blinded randomized controlled trial. Thirty-two nursing students were assigned to an experimental group (n=17) or a control group (n=15). The intervention comprised a theoretical component and a simulation-high fidelity for the experimental group and medium fidelity for the control group. Data were collected with a sociodemographic questionnaire, a theoretical test, a skills checklist, and a Debriefing Assessment Scale. Statistical analysis included the chi-square test, the Mann-Whitney U test, ANOVA, and effect size, at a 5% significance level (α=0.05). RESULTS: both groups showed significant improvement in theoretical knowledge (p<0.05). The groups did not differ significantly in skills (p=0.853). The debriefing experience was positive and similar in both groups. CONCLUSIONS: simulation improved knowledge and skills, with no differences by simulation fidelity level.Franciane Silva Luiz; Isabel Cristina Gonçalves Leite; Luana Vieira Toledo; Kelli Borges dos Santos; André Luiz Silva Alvim; Roberta Teixeira Prado; Angélica da Conceição Oliveira Coelho; Fábio da Costa Carbogim

Debriefing; Randomized controlled trial; Fidelity; Intervention (counseling); Statistical significance; Clinical judgment; Nursing assessment; Nursing; Physical therapy; Medicine; Psychology; Clinical trial

2026-01-01https://doi.org/10.1590/0034-7167-2025-0134Revista Brasileira de Enfermagem 20261Advanced modeling of particle-laden gravity currents over flat and wavy surfaces using a residual-based variational multi-scale approachIn this study, we introduce a numerical framework for simulating dilute particle-laden gravity currents at high Reynolds numbers (Re) using a residual-based variational multi-scale (RBVMS) approach. Our formulation effectively represents the coupling between velocity fine scales and the residual of the density concentration equation, ensuring a more accurate and robust representation of the underlying physical processes. We simulate lock-exchange particle-laden gravity currents across different Reynolds numbers to evaluate the proposed methodology. First, we validate the formulation by modelling gravity currents over flat terrain. Subsequently, we extend our analysis to particle-laden gravity currents over wavy terrains and varying wave heights to explore their influence on flow. Results indicate that floor roughness reduces the front velocity while significantly enhancing instabilities, leading to the earlier emergence of secondary instabilities. Additionally, roughness serves as an additional vorticity generation mechanism. Findings demonstrate that the (RBVMS) framework achieves high accuracy while requiring significantly low mesh resolution.Gabriel Guerra; Roberto M. Velho; Adriano Cortês; José J. Camata; Renato N. Elias; Álvaro L. G. A. Coutinho; Fernando A. Rochinha; Tiago H. F. Jesus; Thais C. A. Empinotti; Paulo L. B. Paraizo

Reynolds number; Representation (politics); Gravity current; Surface finish; Coupling (piping); Vorticity; Mechanics; Physics; Residual; Geology; Terrain; Mathematical analysis; Classical mechanics; Current (fluid); Surface roughness; Mathematics; Geometry

2026-03-18https://doi.org/10.55592/cilamce2025.v5i.14475Anais do ... Congresso Ibero-Latino-Americano de Métodos Computacionais em Engenharia 20261Inteligência artificial na aula de línguas adicionaisEste artigo investiga a percepção de professores de línguas sobre o uso da Inteligência Artificial (IA) no ensino, analisando sua aplicação pedagógica e os desafios envolvidos. Fundamentado em conceitos da Linguística e da Sociolinguística Interacional, o estudo aborda a mediação do professor e os impactos da IA na interação em sala de aula. A pesquisa foi conduzida em uma escola de ensino médio em Minas Gerais, por meio de entrevistas semiestruturadas. Os resultados indicam que os docentes reconhecem as vantagens da IA, como a personalização do ensino e a acessibilidade, mas expressam preocupações sobre a dependência tecnológica e seus impactos na criatividade e nas habilidades sociais dos alunos. Conclui-se que a IA pode ser uma ferramenta pedagógica eficaz quando integrada de forma equilibrada e ética, sem substituir o papel essencial do professor.Hiago de Lima

Meaning (existential); Creativity; Order (exchange); Work (physics); Action (physics); Higher education; Pedagogy; Philosophy; Sociology; Humanities

2026-03-30https://doi.org/10.21166/rext.v13i24.6620Revista de Extensão Tecnológica 20261Infodemic in COVID-19 and its relationship with stress, depression, and anxiety in the elderlyOBJECTIVE: to analyze the phenomenon of the infodemic in COVID-19 and its relation with stress, depression, and anxiety in the elderly. METHOD: quantitative, correlational, cross-sectional study. Non-probabilistic sample of 195 elderly people, who answered a questionnaire for Infodemic, Perceived Stress Scale, Yesavage Geriatric Depression Scale, and Generalized Anxiety Scale through a telephone and/or online self-administered survey. Before you accept informed consent, descriptive and inferential statistics were used to analyze the data. The Ethics Committee approved the study. RESULTS: the average age was 69 ± 6.2 years, and 58% were women. The average number of daily hours devoted to information was 5 ± 2.5, higher among men, with no significant differences between the sexes. Hours of infodemic were inversely related to mental health status, and the more hours of infodemic, the lower the level of stress, depression, and anxiety. CONCLUSION: the infodemic does not necessarily hurt the mental health of the elderly. From a nursing perspective, it is essential to strengthen critical thinking, promote digital literacy, and support networks and safe spaces that enhance autonomy and confront disinformation.Varinia Alejandra Rodríguez-Campo; Sandra Verónica Valenzuela-Suazo; Ricardo Bezerra-Cavalcante; Olivia Sanhueza-Alvarado; Patricia del Tránsito Jara Concha; Aldo Renato Vera-Calzaretta; Pablo Miguel Palma-Novoa

Anxiety; Autonomy; Mental health; Depression (economics); DASS; Scale (ratio); Sample (material); Psychology; Clinical psychology; Construct (python library); Descriptive statistics; Telephone interview

2026-01-01https://doi.org/10.1590/1518-8345.7769.4750Revista Latino-Americana de Enfermagem 20261Infodemia na COVID-19 e sua relação com estresse, depressão e ansiedade em idososObjetivo: analisar o fenômeno da infodemia na COVID-19 e sua relação com estresse, depressão e ansiedade em idosos. Método: estudo quantitativo, correlacional, transversal. Amostra não probabilística de 195 idosos, que responderam a um questionário para: Infodemia, Escala de Estresse Percebido, Escala de Depressão Geriátrica de Yesavage, Escala de Ansiedade Generalizada, por meio de inquérito telefônico e/ou autoaplicável online. Aceitação prévia do consentimento informado. Para análise dos dados, utilizou-se estatística descritiva e inferencial. O estudo foi aprovado pelo Comitê de Ética. Resultados: a média de idade foi de 69 ± 6,2 anos, 58% eram mulheres. O número médio de horas diárias destinadas à informação foi de 5±2,5, sendo maior nos homens, sem diferenças significativas entre os sexos. As horas de infodemia foram inversamente relacionadas à condição de saúde mental, assim como, quanto maior a hora de informação, menor o nível de estresse, depressão e ansiedade. Conclusão: a infodemia não tem necessariamente um impacto negativo na saúde mental dos idosos. A partir da enfermagem, é fundamental fortalecer o pensamento crítico, o letramento digital, promover redes de apoio e espaços seguros que potencializem a autonomia e o enfrentamento da desinformação.Varinia Alejandra Rodríguez-Campo; Sandra Verónica Valenzuela-Suazo; Ricardo Bezerra-Cavalcante; Olivia Sanhueza-Alvarado; Patricia del Tránsito Jara Concha; Aldo Renato Vera-Calzaretta; Pablo Miguel Palma-Novoa

Anxiety; Neuroticism; Autonomy; Life style; Psychology; Humanities; Philosophy

2026-01-01https://doi.org/10.1590/1518-8345.7769.4751Revista Latino-Americana de Enfermagem 20261Multi-target bioactive M(II) pyridine-diamine complexes: synthesis, characterization, in vitro and in silico evaluationIn this study, we synthesized Co(II), Zn(II), and Cd(II) complexes based on a pyridine-derived ligand ( N 1 , N 1 -diethyl -N 2 -(pyridin-2-ylmethyl)ethane-1,2-diamine, DEP-R ). Single-crystal X-ray diffraction analysis confirmed that all complexes possessed distorted trigonal bipyramidal geometries. The complexes exhibited significant potential against both Jack bean (JB) and Bacillus pasteurii (BP) ureases. Notably, the [Cd(DEP-R)Br 2 ] complex exhibited considerable inhibitory potency against urease (IC 50 = 4.51 ± 0.13 and 5.71 ± 0.14 μM for JB and BP, respectively), outperforming the standard inhibitor Thiourea (IC 50 = 11.0 ± 0.62 and 9.10 ± 0.73 μM, respectively). In antioxidant assays, [Co(DEP-R)Cl 2 ] displayed the highest DPPH radical scavenging activity. Additionally, all metal complexes showed a superior in vitro anti-diabetic activity compared to both the standard drug and the uncomplexed DEP-R ligand. Molecular docking results showed that [Cd(DEP-R)Br 2 ] and [Co(DEP-R)Cl 2 ] formed multiple favorable interactions (hydrogen bonding, ionic, and π interactions) with the active sites of urease, Leishmania major oxidoreductase, and human pancreatic α-amylase, supporting their promising in vitro activity. ADMET analysis predicted high GI absorption, Lipinski compliance, moderate solubility, good bioavailability, and low cardiotoxicity, with some neurological and respiratory toxicity risks. DFT-based HOMO–LUMO analysis confirmed the stability and reactivity of the complexes. Overall, the present compounds are promising multi-target metallodrug scaffolds. • Co(II), Zn(II), and Cd(II) pyridine–diamine complexes were synthesized and structurally characterized. • Single-crystal X-ray analysis confirmed distorted trigonal bipyramidal geometries. • The Cd(II) complex showed superior urease inhibition, surpassing thiourea. • Metal complexation markedly enhanced anti-leishmanial, antioxidant, and α-amylase activities. • Docking, ADMET, and DFT studies supported strong multi-target binding and drug-likeness.Saira Nayab; Amjad Subhan; Sher Wali Khan; Dopil Kim; Minyoung Yoon; Seung A. Jeong; Hyosun Lee; Haroon Rashid

Trigonal bipyramidal molecular geometry; In vitro; Docking (animal); DPPH; In silico; Ligand (biochemistry); Thiourea; Reactivity (psychology); Chemistry; Stereochemistry; Biochemistry; Combinatorial chemistry; Antioxidant; In vitro toxicology; Cytotoxicity; Potency

2026-03-31https://doi.org/10.1016/j.bioorg.2026.109808Bioorganic Chemistry 20261ADIPOQ Genotypes, Adiponectin Isoforms, and Hypertension Risk in Pediatric ObesityHuemara Yuri Almeida; Warlley Rosa Cunha; Carla Márcia Moreira Lanna; Josiane Aparecida de Miranda; Riccardo Lacchini; José Eduardo Tanus-Santos; Marcelo R. Luizon; Vanessa de Almeida Belo

Adiponectin; Obesity; Blood pressure; Risk factor; Metabolic syndrome; Medicine; Internal medicine; Endocrinology

2026-03-31https://doi.org/10.1016/j.arcmed.2026.103413Archives of Medical Research 20261Exu-translation – Brazilian art history twisted from a black diaspora cosmoperceptionExu-translation is an Afrocentered approach conceiving interlinguistic translation as an interpretative act that takes Exu as a mode of (re)(co)creation. At the same time that an Exu-translation bows to the feed (i.e., an original), it also implodes it through a (tra)diction of repetition, reinterpretation and modification of meaning, going from a colonial perspective to a decolonial cosmoperception. In this article, we expand Flores and Capilé’s notions of Exu-translation to examine intersemiotic and intercultural translation as an ancestral and Afro-diasporic manifestation of what Venuti terms the translator’s visibility – a concept articulated through the work of contemporary Brazilian artists. We argue that Exu-translation is a heuristic tool through which translation is thought and practiced, thereby reflecting on the (political) insertion of the translator's body into the translation process. First, this work introduces Exu and his multiple identities among Africa and its diaspora, moving on to Exu-translation mode and exploring it beyond the existing literature. Then it analyses and discusses the Exu-translations Fuga e Desaparecimento [Escape and Disappearance] (Francisco, 2020), Sentem para Jantar [Sit down for dinner] (Viana, 2021) and Enfim, Levantar y Andar [Finally rise and walk] (Cerqueira Corrêa, 2023) in the domain of ambiguity in which Exu lives.ANA PAULA VITORIO DA COSTA; Carolina Cerqueira Correa; Malandro Vermelho

Diaspora; Ethnic group; Style (visual arts); Postcolonialism (international relations); History; Anthropology; Ethnology

2026-03-04https://doi.org/10.1080/0907676x.2026.2622482Perspectives 20261Shaping efficiency versus dentin conservation: a micro-CT taper-based analysisOBJECTIVES: To evaluate the influence of instruments with identical tip diameters but increasing taper on shaping efficiency and dentin preservation in the root canals of mandibular molars using micro-CT. MATERIALS AND METHODS: Twelve extracted mandibular molars with Vertucci Type III mesial canals and Type I distal canals were scanned using micro-CT before and after each instrumentation step. Mesial canals were sequentially prepared with 25/0.03, 25/0.05, 25/0.06, and 25/.08v instruments, whereas distal canals were prepared with 40/0.03, 40/0.05, and 40/.06v instruments. Co-registered datasets were used to quantify canal volume, surface area, percentage of unprepared canal surface, dentin removal, and minimum dentin thickness. In addition, dentin thickness values were categorized according to clinically relevant thresholds (< 0.5 mm, 0.5-1.0 mm, and > 1.0 mm). Data were analyzed using generalized linear and mixed-effects models (α = 0.05). RESULTS: In mesial canals, unprepared area decreased significantly with larger tapers; reductions were significant with 25/0.06 (-21.9%) and 25/.08v (-37.9%), but not with 25/0.05. Dentin removal increased markedly and progressively with taper, reaching ~ 350% with 25/.08v compared with 25/0.03 (p < 0.001). In distal canals, taper did not significantly affect the unprepared area; however, dentin removal increased significantly with 40/0.05 and 40/.06v. Directional analyses confirmed a stepwise increase in dentin reduction, following the pattern mesiobuccal > mesiolingual > distal at all levels. Threshold analysis showed that the proportion of dentin thickness measurements within the 0.5-1.0 mm range increased with larger tapers, particularly on the distal aspect of the mesial roots. CONCLUSIONS: Increasing instrument taper improves shaping efficiency in mesial canals but substantially increases dentin removal and shifts dentin thickness toward potentially vulnerable ranges. Conservative taper selection may therefore better balance shaping effectiveness and structural preservation in mandibular molars. CLINICAL RELEVANCE: Larger tapers may improve canal wall contact but can substantially reduce dentin thickness in anatomically vulnerable regions, emphasizing the importance of anatomy-guided taper selection during root canal preparation.Emmanuel João Nogueira Leal da Silva; Thiago Moreira Soares e Silva; Ana Flávia Almeida Barbosa; Graziela dos Santos Massa; Carolina Oliveira De Lima; Marco A. Versiani

Dentin; Root canal; Root Canal Filling Materials; Selection (genetic algorithm); Dentistry; Materials science; Orthodontics

2026-04-01https://doi.org/10.1007/s00784-026-06843-6Clinical Oral Investigations 20261Living Near the Surface: Dive Behavior of Sei Whales ( Balaenoptera borealis ) in the Southwestern Atlantic OceanABSTRACT Understanding the diving behavior of baleen whales in tropical breeding areas is essential for evaluating both ecological functions and anthropogenic threats. In this study, we combined satellite transmitters and generalized additive mixed models (GAMMs) to investigate the dive behavior of sei whales ( Balaenoptera borealis ) in Santos Basin (SB), off southeastern Brazil. A total of 9963 dives were analyzed, revealing a dominance of shallow dives, with 93% of dives occurring at depths ≤ 20 m. Environmental variables such as sea surface temperature, local bathymetry, and chlorophyll concentration significantly influenced dive depth and duration. Cooler waters and deeper offshore areas were associated with longer and deeper dives, while higher surface productivity (indicated by increased chlorophyll a levels) shortened dive times. Behavioral and temporal covariates, including diel period, lunar phase, and dive shape, further modulated diving patterns. The prevalence of shallow diving behavior within the depth range of vessel drafts (≤ 20 m) raises significant conservation concerns, particularly regarding the risk of ship strikes in high‐traffic areas like the Santos Basin. Our findings highlight the behavioral plasticity of sei whales in tropical low‐latitude habitats and emphasize the importance of integrating dive behavior data into marine spatial planning and mitigation strategies. Reducing vessel speed and rerouting traffic in high‐density whale habitats should be considered in the future with further studies to reduce the risk of anthropogenic impacts on this threatened species.CG Baracho-Neto; Leonardo Liberali Wedekin; David Haas; Lucas Lima de Oliveira; Marta Jussara Cremer; Alexandre N. Zerbini

Diel vertical migration; Habitat; Baleen; Dominance (genetics); Range (aeronautics); Threatened species; Submarine pipeline; Bathymetry; Oceanography; Environmental science; Fishery; Ecology; Right whale; Geography; Foraging; Whale; Waves and shallow water; Cetacea

2026-03-31https://doi.org/10.1111/mms.70167Marine Mammal Science 20261Metabolic actions of the gut microbiota in obesity: a systematic reviewIntroduction: Obesity is a multifactorial disease that is difficult to manage and causes several comorbidities, such as physiological and mental disorders, diabetes, stroke, and depression. Worldwide, more than 2.3 billion people are overweight or obese. The gut microbiota interacts with several organs, including the brain, and can regulate metabolism, adiposity, homeostasis, energy balance, and central signaling of appetite and food reward. Objective: To explore and describe the metabolic actions of the gut microbiota and probiotics in the management of patients with obesity. Methods: The systematic review guidelines of the PRISMA Platform were followed. The search was conducted from August to November 2025 in the Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. Study quality was based on the GRADE instrument, and risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: A total of 125 articles were found. A total of 32 articles were fully evaluated, and 21 were included and developed in this systematic review. Using the Cochrane risk of bias tool, the overall assessment resulted in 23 studies with a high risk of bias and 25 studies that did not meet the GRADE and AMSTAR-2 criteria. Most studies presented homogeneous results, with X2=74.8%>50%. It was concluded that bidirectional signaling occurs within the gut-brain axis in the pathophysiology of obesity, mediated by metabolic, endocrine, neural, and immune system mechanisms. Fecal microbiota transplantation and supplementation with probiotics and prebiotics may be potential treatments for obesity. Diet is a determining factor for healthy colonization of the gut microbiota. Studies in obese humans also found a lower proportion of Bacteroidetes compared to those in normal-weight individuals. After weight loss, the proportion of Firmicutes is reduced and becomes more similar to that of lean individuals. Inulin supplementation can significantly promote intestinal bacterial diversity and improve gut microbiota dysbiosis in obese patients. Low-carb diets and time-restricted feeding are effective in weight management and produce profound changes in the gut microbiome and metabolome, in addition to caloric restriction.Cristina Moraes Osório Leite; Pablo Wanglon Richter; Cristiano Villanova Andrade; Fernanda Assis Vianello Alvim; Francisco Alfredo Sampaio Cruz; Glauce Lippi de Oliveira; Isabele Helaine Rabelo Dias; Leonardo Vieira Lima; Vaneska Carvalho Bezerra de Brito; F Durante

Gut flora; Overweight; Systematic review; Obesity; Fecal bacteriotherapy; Disease; Appetite; Immune system; Risk factor; Medicine; Bioinformatics; Physiology; Biology; Immunology; Meta-analysis; Intensive care medicine; MEDLINE; Homogeneous; Gut–brain axis

2026-03-31https://doi.org/10.54448/ijn26207International Journal of Nutrology 20261Judith ButlerElizabeth Wissinger; Natalia Rosa Epaminondas; Jamilie Santios de Souza

2026-03-31https://doi.org/10.26563/dobras.v19i46.1987dObra[s] – revista da Associação Brasileira de Estudos de Pesquisas em Moda

2026160 anos da criação da Ação Católica Rural (ACR)No ano em que completa seis décadas de sua fundação (1965-2025), a Ação Católica Rural (ACR) segue oferecendo epifanias valiosas sobre resistência religiosa em contextos autoritários. Este artigo analisa como o movimento, idealizado por Dom Helder Camara no Nordeste brasileiro pós-golpe de 1964 (que em 2025 marcou 61 anos), atuou como experiência intersticial, entre a hierarquia eclesiástica e as demandas camponesas. Fundamentado na análise documental do jornal Grito no Nordeste, com os conceitos de hibridismo e zonas de contato, demonstramos como a ACR reinterpretou o catolicismo pós-Vaticano II, articulando ritual religioso com organização sindical. Em um contexto de repressão militar e pluralização de vozes políticas, o movimento operou nas brechas do sistema, mediando tradições católicas e reivindicações secularizadas. Seu legado desafia dicotomias convencionais entre religioso e político, oferecendo chaves para entender práticas contemporâneas de fé engajada. A análise revela como esses espaços podem gerar inovação social mesmo sob regimes autoritários.Felipe de Lima França

Context (archaeology); Face (sociological concept); Politics; Field (mathematics); Hierarchy; Humanities; Sociology; Political science

2026-03-31https://doi.org/10.20396/csr.v28n00.8680240Ciencias Sociales y Religión 20261Investigation of Ferricyanide Intercalation in Layered Double Hidroxide and Layered Hidroxide Salts by DFT Calculations for&nbsp;Anion Exchange ApplicationsAna Carolina Hammes; Fernando Wypych; Sérgio R. Tavares; Alexandre A. Leitão

Gibbs free energy; Chemical stability; Aqueous solution; Ferricyanide; Ion exchange; Intercalation (chemistry); Ion; Structural stability; Chemistry; Inorganic chemistry; Materials science; Thermodynamics; Physical chemistry; Ferrocyanide; Stability (learning theory); Hydration energy

2026-01-01https://doi.org/10.2139/ssrn.6501982SSRN Electronic Journal 20261Sodium alginate/biphasic calcium phosphate/graphene oxide composite films for biomaterials applicationsCalcium phosphate composite films reinforced with graphene oxide (GO) were developed to enhance the performance of biomaterials. Graphene, due to its exceptional mechanical strength, biocompatibility and large surface area, was incorporated into sodium alginate/biphasic calcium phosphate films prepared by casting technique. The effect of GO content (0-1%) on film composition, morphology, mechanical strength, swelling degree and in vitro biocompatibility was evaluated. The incorporation of GO increased tensile strength by approximately 32%. The swelling degree increased with GO content, suggesting enhanced hydrophilicity and a modulation of the hydrogel network crosslinking, which improves structural stability. GO addition also promoted greater osteoblast spreading, along with extensive extracellular matrix secretion and deposition. The results indicated that the addition of graphene oxide improved mechanical and biological performance of composite films, confirming their potential for biomedical applications.Andreza Menezes Lima; Laís de Souza Alves; Rebecca Vasconcellos; Michele Munk; Érika Costa de Alvarenga; Roseli Marins Balestra; Alexandre Antunes Ribeiro

Biocompatibility; Composite number; Swelling; Graphene; Ultimate tensile strength; Oxide; Calcium; Materials science; Composite material; Chemical engineering; Sodium; Simulated body fluid; Casting; Calcium oxide; Phosphate

2026-04-01https://doi.org/10.1016/j.nxbio.2026.100021Next Bioengineering 20261Moda e sociedade: leituras contemporâneasinterior de um universo onde o sistema da moda passa a desempenhar um papel fundamental.Maria Lucia Bueno; Henrique Grimaldi Figueredo

Natural (archaeology); Subject (documents)

2026-03-31https://doi.org/10.26563/dobras.v19i46.2061dObra[s] – revista da Associação Brasileira de Estudos de Pesquisas em Moda 20261Mortars containing eucalyptus wood ash and sewage sludge: eco-efficiency optimization using a central composite design and the desirability functionThe increasing generation of industrial solid waste demands sustainable solutions for its reuse. The literature still lacks studies focused on optimizing the use of eucalyptus wood ash and sewage treatment plant (STP) sludge in cement-lime mortars. This study aims to fill this gap by optimizing the eco-efficiency of cement-lime mortars incorporating these residues, thereby promoting more sustainable practices in the construction industry. A Central Composite Design (CCD) was elaborated to define the mortar compositions to be investigated, along with the evaluation of compressive strength and flexural tensile strength. The statistical desirability function (DSJ) was applied to balance mechanical performance and sustainable resource consumption, seeking the most suitable formulation for the mixtures. Eco-efficiency optimization was conducted under practical masonry workability constraints rather than aiming at maximum mechanical strength without complying with standardized mortar consistency requirements. The results indicated that the lime addition played a predominant role in the mechanical strength of the mortars, whereas the addition of residues showed a less significant effect. The application of the desirability function enabled the identification of the most eco-efficient mortar composition. Regression analyses with coefficients of determination exceeding 80% demonstrated a good correlation between experimental data and the developed mathematical models. These findings contribute to the development of sustainable cementitious materials, demonstrating that the combined use of eucalyptus wood ash and STP sludge in mortar production is technically feasible and environmentally advantageous. This approach promotes the valorization of industrial residues without compromising mortar strength, advancing sustainable construction practices.Roziani Maria Gomes; José Maria Franco de Carvalho; Gustavo Henrique Nalon; Hellen Regina de Carvalho Veloso Moura; Flávio Antônio Ferreira; Antônio Cléber Gonçalves Tibiriçá; José Carlos Lopes Ribeiro

Mortar; Flexural strength; Cementitious; Compressive strength; Masonry; Ultimate tensile strength; Lime; Sustainability; Eucalyptus; Environmental science; Waste management; Sewage sludge; Cement; Bamboo; Fly ash; Wood ash

2026-04-02https://doi.org/10.3389/fbuil.2026.1776005Frontiers in Built Environment 20261Efficacy of Surface Sealant on Clinical Performance of Composite Resin Restorations: A Systematic ReviewOBJECTIVE: This systematic review evaluated the effect of surface sealant application on the clinical performance of composite resin restorations. MATERIALS AND METHODS: The review followed PRISMA 2020 guidelines and was registered in PROSPERO. Searches were conducted in Embase, PubMed, Scopus, Web of Science, and Google Scholar, supplemented by manual reference screening. Only randomized clinical trials were included. Risk of bias was assessed using the Cochrane RoB 2.0 tool. RESULTS: Of 717 records identified, six trials met eligibility criteria. Two were low risk of bias, three had some concerns, and one was high risk. Clinical performance was evaluated using USPHS (three studies), FDI (one study), and Moffa-Lugassy (two studies) criteria, along with postoperative sensitivity scales. Surface sealant application improved clinical outcomes in four studies. Marginal adaptation improved in three trials, two of which also showed reduced marginal discoloration. Surface wear decreased in two studies, while no significant effects were observed for surface roughness or postoperative sensitivity. Findings regarding color matching were inconsistent across studies. CONCLUSIONS: Surface sealants may enhance clinical performance of composite restorations, particularly regarding wear resistance, marginal integrity, and marginal staining. Evidence remains limited, and further well-designed randomized trials with standardized outcomes are required to strengthen these findings. CLINICAL SIGNIFICANCE: Surface sealants can improve marginal adaptation, reduce wear, and help maintain color stability in composite restorations, contributing to their longevity and esthetic performance.Daniella Montes Souza; Bruno S. Santos; Maria Eduarda Ferreira Carvalho; Aline Spagnol Fedoce‐Silva

Sealant; Randomized controlled trial; Clinical trial; Meta-analysis; Composite number; Systematic review; Surface roughness; Medicine; Dentistry; Orthodontics; Resin composite; Relative risk

2026-04-02https://doi.org/10.1111/jerd.70144Journal of Esthetic and Restorative Dentistry 20261On models of regular black holes from effective sourcesAbstract We discuss the method to obtain regular black hole metrics based on the effective source formalism. Our construction uses the sources originated from higher-derivative and nonlocal gravities, yet the procedure is very general. We comment on the ambiguity existing in the choice of effective pressures. As concrete examples, we analyze the horizon structure of generalized Lee—Wick black holes and compare two different models based on a Gaussian effective source.Nicolò Burzillà; Breno L. Giacchini; Leonardo Modesto; Tibério de Paula Netto

Horizon; Ambiguity; Black hole (networking); Black box; Gaussian; Physics; Computer science; Mathematics; Theoretical physics; Algorithm; Statistical physics

2026-02-01https://doi.org/10.1088/1742-6596/3177/1/012031Journal of Physics Conference Series 20261Effective delta sources and Newtonian limit in nonlocal gravityThomas M. Sangy; Nicolò Burzillà; Breno L. Giacchini; Tibério de Paula Netto

Limit (mathematics); Delta; Non-Newtonian fluid; Stability (learning theory); Newtonian fluid; Physics; Classical mechanics; Mathematical analysis

2026-04-01https://doi.org/10.1103/8hdr-br8lPhysical review. D/Physical review. D. 20261Rumo ao ideal andrógino: moda e identidade sexualFrédéric Monneyron; Henrique Grimaldi Figueredo

2026-03-31https://doi.org/10.26563/dobras.v19i46.2064dObra[s] – revista da Associação Brasileira de Estudos de Pesquisas em Moda

20261Uso terapêutico da cannabis e políticas de moralidade: disputas e controvérsias nos poderes Executivo, Legislativo e JudiciárioObserving the rapid changes regarding the topic of the therapeutic use of cannabis and its disputes in Brazil, this paper addresses the turnaround that has occurred in recent years in the health sphere related to the uses of the plant for therapeutic purposes. Considering that the public debate on the implementation of a morality policy is permeated by tensions, conflicts and controversies, it is clear that there is a great moral dispute that configures a split between the definition of cannabis as a therapeutic product and as an illicit drug. Based on a qualitative methodology, texts, videos, images and some interviews were conducted with health professionals were analyzed. These materials, treated as important factors in contemporary social and political life, were analyzed as social artifacts, because by changing the legal status of the cannabis plant by guaranteeing access to the right to health, they also end up allowing cultivation on national soil, causing other diverse social effects. Therefore, it was observed that institutions of the Executive Branch, such as the National Health Surveillance Agency and the Federal Council of Medicine, issued some resolutions that changed the status of the plant by making it a therapeutic possibility, but always relying on scientific evidence to justify their positions. In relation to the Judiciary Branch, the changes occurred through Habeas Corpus, safe conducts and other decisions that mainly concern the permission to cultivate a plant banned in Brazil for use as a health therapy. Although it has followed and still follows a path mainly through the legal and executive channels, the debate began in the Legislative Branch in 2014, where among many projects, Bill 399 of 2015 was the one that gained the most notoriety, but this debate has been stagnant for almost five years in the National Congress.Marco Vinicius de Castro; Paulo César Pontes Fraga

Cannabis; Legislature; Politics; Agency (philosophy); Public health; Morality; Political science; Law; Public administration; Sociology; Criminology

2026-04-01https://doi.org/10.22409/antropolitica2026.v58.i1.a68504Antropolítica - Revista Contemporânea de Antropologia 2026160 anos da criação da Ação Católica Rural (ACR)No ano em que completa seis décadas de sua fundação (1965-2025), a Ação Católica Rural (ACR) segue oferecendo epifanias valiosas sobre resistência religiosa em contextos autoritários. Este artigo analisa como o movimento, idealizado por Dom Helder Camara no Nordeste brasileiro pós-golpe de 1964 (que em 2025 marcou 61 anos), atuou como experiência intersticial, entre a hierarquia eclesiástica e as demandas camponesas. Fundamentado na análise documental do jornal Grito no Nordeste, com os conceitos de hibridismo e zonas de contato, demonstramos como a ACR reinterpretou o catolicismo pós-Vaticano II, articulando ritual religioso com organização sindical. Em um contexto de repressão militar e pluralização de vozes políticas, o movimento operou nas brechas do sistema, mediando tradições católicas e reivindicações secularizadas. Seu legado desafia dicotomias convencionais entre religioso e político, oferecendo chaves para entender práticas contemporâneas de fé engajada. A análise revela como esses espaços podem gerar inovação social mesmo sob regimes autoritários.Felipe de Lima França

Context (archaeology); Face (sociological concept); Politics; Field (mathematics); Hierarchy; Humanities; Sociology; Political science

2026-03-31https://doi.org/10.20396/csr.v28i00.8680240Ciencias Sociales y Religión 20261How Do Faster and Slower Bench Press Eccentric Tempos Affect the Concentric Performance of Paralympic Powerlifting Athletes During High and Maximal Intensity Loads?Background: As Para-Powerlifting (PP) athletes need the maximum bench press concentric strength performance during competitions, the velocity of the eccentric phase could be critical to the sport’s success. Methods: Through eccentric tempo modification, normative, faster, and slower bench press eccentric velocities were tested on 16 experienced PP athletes. Mean propulsive velocity (MPV), maximum velocity (Vmax), and power were measured during a single bench press set at different loads (90% and 100% of 1RM) and tempos. After the bench press set, Maximal isometric force (MIF), rate of force development (RFD), impulse, variability, and maximal average force (MAF) were obtained through an isometric bench press test. Results: Slower and faster tempos were not different in concentric performance than a normative tempo at the 90% 1RM load. A faster tempo generated higher MPV and Vmax than a normative one at the 100% 1RM load. A normative tempo produced higher MIF than a slower tempo, and higher impulse than a faster tempo after a 90% 1RM bench press set. Conclusions: PP athletes seem to have an optimized technique in submaximal loads; however, they may need faster eccentric velocities in the 100% 1RM load to improve their concentric performance.Renato Méndez-delCanto; Felipe J. Aidar; Alfonso López Díaz-de-Durana; Esteban Aedo-Muñoz; Ciro José Brito; Nuno Domingos Garrido; Víctor Machado Reis; Pantelis Τ. Nikolaidis

Bench press; Concentric; Eccentric; Isometric exercise; Athletes; Intensity (physics); Mathematics; Physical medicine and rehabilitation; Sports biomechanics; Impulse (physics)

2026-03-31https://doi.org/10.3390/physiologia6020025Physiologia 20261Roupas comuns/incomuns: destruindo e reparando a experiência nas roupas-arte contemporâneaO artigo analisa o uso da roupa na arte contemporânea, desde a arte têxtil do século XX até a roupa como forma de arte contemporânea. A diferença é que a arte têxtil mantém os valores funcionais e distintivos da roupa, enquanto a arte contemporânea da roupa apaga quaisquer valores de uso para produzir significados relacionados à identidade, cultura e memória. As roupas-arte ocupam um espaço polissêmico que parece se desdobrar entre dois paradigmas sintéticos: a destruição ou esvaziamento da roupa, como exemplificado pela gigantesca instalação *Personnes*, de Christian Boltanski, de 2010, onde roupas vazias evocam a ausência do corpo; e a produção e reparação do sujeito, como exemplificado pela obra de Louise Bourgeois da década de 1990, que usou esculturas de roupas e tecidos para reconstruir um novo eu corpóreo e reparar sua autobiografia. Esse trabalho antecipa a Arte da Reparação, uma prática contemporânea com implicações filosóficas, políticas e culturais que aborda memórias coletivas de traumas, como os causados pelo colonialismo e pela guerra, bem como o tema da sobrevivência humana em um planeta dramaticamente danificado. Nesse contexto teórico, as roupas-arte surgem como uma prática contemporânea significativa de produção de significado, questionando a relação entre arte, experiência, cultura e memória individual e coletiva.Maria Antonietta Trasforini; Marcelo Ribeiro Vasconcelos

Politics; Subject (documents); Context (archaeology); Period (music); Government (linguistics); Humanities; Art; Philosophy

2026-03-31https://doi.org/10.26563/dobras.v19i46.2063dObra[s] – revista da Associação Brasileira de Estudos de Pesquisas em Moda 20261A study on the structure of thinking in HusserlIn this article, I present the Prolegomena, the Logical Investigations, Ideas I and II as parts of a coherent argument whose theme is the structure of thinking. Underlying the argument is the premise that knowledge of universals is possible. The fundamental ideas are (i) all knowledge is conducted by an intentional consciousness, (ii) all thinking is composed of intentional acts to which contents correspond, (iii) consciousness is a unity in continuous flux. In the Prolegomena, Husserl defines the object of investigation and the need to base knowledge of universals on experiences. In Investigations I-IV, he highlights the conditions for such an investigation. In the Fifth Investigation, he proposes elements of the structure of thinking. In the Sixth Investigation, he presents how it works. In Ideas I, he analyzes the structure of thinking and establishes the nomenclature. In Ideas II, Husserl presents how the structure of thinking is filled out and from it the constitution of essences takes place.Nathalie Barbosa de La Cadena

Problem of universals; Argument (complex analysis); Object (grammar); Premise; Consciousness; Theme (computing); Constitution; Normative; Generalization; Epistemology; Philosophy; Meaning (existential); Exposition (narrative)

2026-03-24https://doi.org/10.33361/rpq.2026.v.14.n.39.1442Revista Pesquisa Qualitativa 20261Adoption and Barriers to CAD/CAM Technology Among Dentists in the Dominican Republic: A Cross-Sectional StudyINTRODUCTION: Computer-aided design and computer-aided manufacturing (CAD/CAM) have transformed modern dentistry, yet evidence from the Caribbean remains limited. OBJECTIVE: To assess CAD/CAM adoption among dentists in the Dominican Republic and identify associated demographic and professional factors, barriers, and future adoption intentions. METHODS: A nationwide cross-sectional online survey was administered to dentists registered with the Dominican Dental Association between June and November 2024. A validated questionnaire was distributed through professional networks and social media. Data were analysed using descriptive statistics, chi-square tests, and multivariable logistic regression to examine associations between adoption and specialty, practice type, postgraduate education, and years since graduation. RESULTS: A total of 374 dentists responded; the adoption rate was 39.3%. Adoption was significantly associated with specialty and practice type (P < .001), but not with years since graduation (P = .740) or geographic region (P = .464). Prosthodontists (odds ratios [OR] = 9.16) and orthodontists (OR = 7.50) were the most likely adopters, while dentists in public institutions (OR = 0.18) and academia (OR = 0.28) were less likely to use CAD/CAM. Among nonusers, major barriers included high costs (41.9%). However, 71.4% expressed intention to adopt CAD/CAM. CONCLUSIONS: Adoption of CAD/CAM in the Dominican Republic is shaped by specialty and practice setting but limited by financial and educational barriers. Expanding training opportunities and reducing costs may facilitate more equitable digital integration. CLINICAL SIGNIFICANCE: Understanding determinants of CAD/CAM adoption can guide targeted training and policy strategies to improve efficiency and care quality in resource-limited regions.Patrícia Grau Grullón; Rodrigo Varella de Carvalho; Gabriela Morales Velázquez; Leyani Pérez; Roxana Crespo; Giana da Silveira Lima

MEDLINE; Quality (philosophy); Public health; Health services; Family medicine; Medicine; Environmental health; Nursing; Business

2026-04-03https://doi.org/10.1016/j.identj.2026.109411International Dental Journal 20261Aplicação verbal do checklist de cirurgia segura: análise crítica da práticaObjetivo: Analisar a conformidade da aplicação do Checklist de Cirurgia Segura, com ênfase na checagem verbal, em um hospital público de ensino. Métodos: Estudo transversal descritivo de abordagem quantitativa baseado na observação direta de 193 procedimentos cirúrgicos realizados entre abril e agosto de 2025. A conformidade foi definida pela confirmação verbal e pelo registro em cada item. Os dados foram tratados por estatística descritiva e univariada, utilizando um instrumento elaborado pela pesquisadora fundamentado no modelo-padrão do Checklist de Cirurgia Segura da Organização Mundial da Saúde, em que se incluem campos para registrar a checagem verbal de cada item do checklist, o registro no prontuário e o cumprimento das etapas. O estudo foi aprovado pelo Comitê de Ética em Pesquisa da instituição sede do estudo, via Plataforma Brasil (CAAE 86548025.7.0000.5133, sob o Parecer 7.500.360) e todos os participantes assinaram o Termo de Consentimento Livre e Esclarecido. Resultados: No presente estudo, os mais altos índices de conformidade foram observados no primeiro momento do checklist, sobretudo na confirmação da identidade do paciente, do sítio cirúrgico, do procedimento e na verificação do termo de consentimento assinado. Tal achado sugere que os profissionais tendem a priorizar ações de maior relevância ética e legal, em detrimento dos aspectos técnicos do processo cirúrgico. A confirmação por registro foi significativamente mais frequente (p<0,05) que a verbal, revelando adesão predominantemente burocrática à ferramenta. A conformidade global foi baixa e decrescente entre os momentos: sign in (22,16%), timeout (16,11%) e sign out (9,40%). Conclusão: O estudo revelou baixa conformidade na aplicação do Checklist de Cirurgia Segura em voz alta, com redução progressiva da checagem nos três momentos e uso predominantemente burocrático, em detrimento de sua função preventiva e comunicativa.Cristina Rocha Amaral; Roberta Teixeira Prado; André Luiz Silva Alvim; Andréia Guerra Siman; Fabio da Costa Carbogim; Juliana Balbinot Reis Girondi; Isadora Caldeira Belini; Thiago Rodrigues dos Santos; Hérica Silva Dutra; Luciane Ribeiro de Faria

Checklist; Sign (mathematics); Timeout; Neuropsychology; Psychology; Humanities; Philosophy

2026-04-02https://doi.org/10.5327/z1414-44251083Revista Sobecc 20261The works of Alfred Agache in Petrópolis (Rio de Janeiro, Brazil) during the Estado Novo [New State] in Brazil (1937-1945)This article seeks to shed light on the underexplored visit of the French urban planner Alfred Agache to the interior of the state of Rio de Janeiro in the early 1940s, with particular emphasis on his work in Petrópolis. It further aims to advance an understanding of how tourism emerged as a central theme in Agache’s proposals during this period. To achieve this objective, the study examines talks he gave on the subject, based on the proposals that he and his team—including figures such as Abelardo Coimbra Bueno—developed for the urbanization of the city of Petrópolis. The research was grounded on documentary sources produced between 1937 and 1945. Lastly, the study analyzes the ideas proposed by the urban planners, comparing them with the interventions actually implemented over the following years, when tourism came to play a decisive role in shaping the city.André Barcelos Damasceno Daibert

Tourism; Theme (computing); Urbanization; Planner; State (computer science); Work (physics); History; Political science; Sociology; Humanities; Urban tourism; Urban planning

2026-03-06https://doi.org/10.22296/2317-1529.rbeur.202606enRevista Brasileira de Estudos Urbanos e Regionais 20261Measurement properties of the Sexual Risk Behaviors Scale (SRBS) in university students in BrazilOBJECTIVE: This study aimed to translate and evaluate the measurement properties of the Sexual Risk Behaviors Scale into Brazilian Portuguese for use in university students. METHODS: Content validity was assessed by experts and Brazilian adults. Structural validity was assessed using a confirmatory factor analysis. Internal consistency and test-retest reliability were assessed using McDonald's Omega and intraclass correlation coefficient (ICC), respectively. Measurement invariance between females and males was evaluated using multigroup confirmatory factor analysis. The measurement error and floor and ceiling effects were also evaluated. RESULTS: The experts and Brazilian adults suggested that the five-item Sexual Risk Behaviors Scale was more relevant, comprehensive, and comprehensible. In total (n=633; 22.8±2.0 years), 362 (57.2%) women and 271 (42.8%) men participated in the study. Structural validity indicated a one-factor structure as the best-fitting model, and the internal consistency was sufficient (McDonald's Omega=0.723). There was measurement invariance between females and males. The test-retest reliability was found to be sufficient (ICC=0.873). Moreover, no systematic error were observed. There was a floor effect across the entire sample. CONCLUSION: The Sexual Risk Behaviors Scale is valid and reliable for assessing sexual risk behaviors in university students in Brazil.Jaíne Dalmolin; Guilherme Tavares de Arruda; Erisvan Vieira da Silva; Caroline Arboite de Fraga; Amanda dos Santos Candido; Hedionéia Maria Foletto Pivetta; Melissa Medeiros Braz

Scale (ratio); Sexual behavior; Psychometrics; Risk perception; Psychology; Social psychology; Developmental psychology; Applied psychology; Clinical psychology

2026-01-01https://doi.org/10.31744/einstein_journal/2026ao1714Einstein (São Paulo) 20261Desfechos e instrumentos padronizados utilizados em intervenções fisioterapêuticas via telessaúde para crianças com paralisia cerebral: uma revisão de escopo usando a <scp>CIF</scp>OBJETIVO: Identificar os desfechos e instrumentos padronizados utilizados para medir mudanças após intervenções fisioterapêuticas realizadas via telessaúde em crianças e jovens com paralisia cerebral, de acordo com os domínios da Classificação Internacional de Funcionalidade, Incapacidade e Saúde, além de descrever a modalidade de aplicação desses instrumentos. MÉTODOS: Esta revisão de escopo seguiu as etapas do JBI e identificou estudos sobre intervenções fisioterapêuticas realizadas via telessaúde em crianças e jovens de até 20 anos, utilizando instrumentos padronizados de avaliação. As buscas foram realizadas nas bases MEDLINE/PubMed, Embase, Cochrane, Scopus, Web of Science, PEDro, Lilacs e literatura cinzenta, sem restrições de data ou idioma. RESULTADOS: Quatorze estudos (625 participantes, faixa etária de 6 meses a 20 anos, todos os níveis do Sistema de Classificação da Função Motora Grossa) atenderam aos critérios de inclusão. Os desfechos estavam concentrados principalmente no domínio de atividade (59,3%), seguidos pelos domínios de função e estrutura corporal (29,6%) e participação (22,2%). Foram utilizados trinta instrumentos padronizados; os mais frequentes foram a Assisting Hand Assessment (n = 5) e a Medida da Função Motora Grossa (n = 3). A maioria dos instrumentos padronizados foi aplicada presencialmente (68,2%), outros utilizaram métodos híbridos (telessaúde e presencial: 18,2%) ou não especificaram o modo de aplicação (6,8%). Apenas dois estudos aplicaram todos os instrumentos via telessaúde. INTERPRETAÇÃO: Os desfechos e instrumentos padronizados identificados nesta revisão são em sua maioria do domínio de atividade, refletindo as prioridades dos pais. As avaliações presenciais permanecem como a modalidade preferida para a realização de avaliações padronizadas. Novas pesquisas são necessárias para investigar a viabilidade e as propriedades de medida do uso de instrumentos padronizados via telessaúde.Isabella Saraiva Christovão; Paula S de C Chagas; Ana Alice V. Aniceto; Daiane A. de O. Bettoni; Lorena Costa Ferreira; Hércules Ribeiro Leite; A.F. Camargos

Political science; Humanities; Medicine; Gynecology

2026-04-02https://doi.org/10.1111/dmcn.70214Developmental Medicine & Child Neurology 20261Regional drivers of green technological competences in BrazilAbstract This paper analyzes the determinants of green technological competences based on patent data across Brazilian regions between 2000 and 2020, focusing on the influence of green employment and specialization in natural resource-based sectors. Conditional and unconditional quantile regression approaches are employed to capture regional heterogeneity across the distribution of technological performance. The results indicate that the share of green employment is negatively and significantly associated with green technological competences at several points along the distribution, suggesting that such jobs tend to be concentrated in low-tech activities. In turn, natural natural-resource based sectors show positive effects at specific quantiles which indicates that, under certain conditions, a natural resource-based economy can stimulate environmental innovation. However, these effects are not generalized, highlighting the importance of public policies and institutional arrangements that support productive transformation and the strengthening of local technological capabilities.Ludmilla R. C. Gonçalves; Eduardo GONÇALVES; Rosa Lívia Gonçalves Montenegro

Quantile regression; Distribution (mathematics); Technological change; Natural (archaeology); Quantile; Natural resource; Economic geography; Economics; Business; Public policy; Panel data; Regional science; Economic system

2026-01-01https://doi.org/10.1590/1980-53575611lerEstudos Econômicos (São Paulo) 20261Vigilância alimentar e nutricional no Brasil: estrutura e processo de trabalho da atenção básicaResumo Introdução: A Vigilância Alimentar e Nutricional (VAN) reestrutura práticas e serviços, melhorando os padrões alimentares e o estado nutricional da população. Objetivo: Analisar fatores associados à adequação da estrutura das Unidades Básicas de Saúde (UBS) e o processo de trabalho (PT) das equipes de Atenção Básica (Eqs-AB) e Núcleos Ampliados de Saúde da Família e Atenção Primária (NASF-AB), para a realização da VAN no Brasil. Método: Estudo transversal, com dados do Programa de Melhoria do Acesso e da Qualidade (PMAQ-AB/3º ciclo). Para a análise da associação, estimou-se a razão de prevalência (RP) e intervalos de confiança de 95% (IC95%), pela Regressão de Poisson, com variância robusta. Resultados: Os fatores associados à adequação da estrutura e processo de trabalho das Eqs-AB e dos NASF foram, respectivamente: ser da Região Nordeste (RP=1,704; IC95% 1,31–2,21), municípios com alto índice de desenvolvimento (RP=1,24; IC95% 1,05–1,47) e cobertura de 100% de Estratégia de Saúde da Família (ESF) (RP=1,25; IC95% 1,08–1,43); municípios da Região Nordeste (RP=1,45; IC95% 1,33–1,57), com 100% de cobertura de Estratégia Saúde da Família — ESF (RP=1,08; IC95% 1,02–1,14) e cobertura de mais de 75% do Sistema de VAN (RP=1,26; IC95% 1,01–1,58); municípios de porte populacional grande e muito grande apresentaram duas vezes maior probabilidade de adequação. Conclusão: São necessárias melhorias, investimentos, sensibilização das equipes, NASF-AB e gestores quanto à importância e organização da VAN.Isabel Cristina Bento; Guilherme de Andrade Ruela

Work (physics); Population; Data collection; Productivity; Quality (philosophy); Food consumption; Agricultural science; Geography

2026-01-01https://doi.org/10.1590/1414-462x202634010571Cadernos Saúde Coletiva 20261Development and validation of a nursing clinical protocol for dermatitis associated with incontinence in pediatricsABSTRACT Objective: To develop and validate the content of a nursing clinical protocol for the treatment of children with dermatitis associated with incontinence using low-intensity laser therapy as an adjuvant. Method: Methodological study conducted between 2022 and 2024, through the stages of literature review, construction, and validation of the clinical protocol. This protocol was structured into 10 topics based on the recommendations of the methodological guidelines for the development of clinical protocols from the Ministry of Health, evaluated by specialist nurses considering the themes of clarity, coherence, relevance, and completeness. Results: The contents were structured around the use of disposable diapers with frequent changes, the use of appropriate products for hygiene, and the application of products for skin protection, as recommended by the literature, in addition to the use of Low-Intensity Laser Therapy as an adjuvant treatment. The content validation index for each verified topic ranged from 91.6% to 100%. Conclusion: The clinical protocol was considered valid for the treatment of dermatitis associated with incontinence in the pediatric context.Gabriela Beims Gapski; Juliana Balbinot Reis Girondi; Jane Cristina Anders; Kelli Borges dos Santos; Anna Julia Trindade Bittencourt

Protocol (science); Christian ministry; MEDLINE; Clinical trial; Content validity; Pediatric nursing; Medicine; Physical therapy; Intensive care medicine; Family medicine; Nursing; Medical physics; Urinary incontinence

2026-01-01https://doi.org/10.1590/ce.v31i0.99330enCogitare Enfermagem 20261Elaboração e validação de protocolo clínico de enfermagem para dermatite associada à incontinência em pediatriaRESUMO Objetivo: Elaborar e validar o conteúdo de um protocolo clínico de enfermagem para o tratamento de crianças com dermatite associada à incontinência com o uso adjuvante da laserterapia de baixa intensidade. Método: Estudo metodológico desenvolvido entre 2022 e 2024, através das etapas de revisão de literatura, construção e validação do protocolo clínico. Este protocolo foi estruturado em 10 tópicos a partir da recomendação das diretrizes metodológicas para elaboração de protocolos clínicos do Ministério da Saúde, avaliado por enfermeiros especialistas considerando os temas de clareza, coerência, relevância e completude. Resultados: Os conteúdos foram estruturados em torno do uso de fraldas descartáveis com trocas frequentes, uso de produtos adequados para a higiene e aplicação de produtos para a proteção da pele, conforme recomendados pela literatura, além do emprego da Laserterapia de Baixa Intensidade como tratamento adjuvante. O índice de validação de conteúdo para cada tópico verificado variou entre 91,6% e 100%. Conclusão: O protocolo clínico foi considerado válido para o tratamento de dermatites associadas à incontinência no contexto pediátrico.Gabriela Beims Gapski; Juliana Balbinot Reis Girondi; Jane Cristina Anders; Kelli Borges dos Santos; Anna Julia Trindade Bittencourt

Nursing care; Context (archaeology); MEDLINE; Nursing process; Medicine; Gynecology

2026-01-01https://doi.org/10.1590/ce.v31i0.99330ptCogitare Enfermagem 20261Artigo: DIÁLOGOS ENTRE PERFORMATIVIDADE DE GÊNERO E PERFORMANCE ARTÍSTICA NA PRODUÇÃO DE ANA MENDIETAO presente artigo pretende trazer diálogos e entrecruzamentos entre performatividade de gênero e performance artística. Entendendo o gênero a partir da ótica da performatividade — proposta fundamentada pela teórica Judith Butler —, ou seja, da linguagem, gestualidade e corporalidade, a pesquisa propõe pensar a performance artística, atrelada também ao corpo e suas movimentações, como potência de desordem das normas de gênero. Sob uma perspectiva territorialmente localizada, este trabalho se debruça na produção e vida de Ana Mendieta e de como ela encara em suas práticas performáticas as transgressões do "ser" mulher. A abordagem focada na produção da artista permite guiar o debate a partir de uma lógica não universalizante do gênero e da prática artística.Sarah Elen Souza Oliveira; Renata Cristina de Oliveira Maia Zago Mazzoni Marcato

Context (archaeology); Work (physics); Turning point; Order (exchange); Philosophy; Humanities; Art

2026-03-30https://doi.org/10.33871/sensorium.2026.13.11328Art&Sensorium 20261Elaboración y validación de un protocolo clínico de enfermería para dermatitis asociada a la incontinencia en pediatríaRESUMEN Objetivo: Elaborar y validar el contenido de un protocolo clínico de enfermería para el tratamiento de niños con dermatitis asociada a la incontinencia con el uso adyuvante de la laserterapia de baja intensidad. Método: Estudio metodológico desarrollado entre 2022 y 2024, a través de las etapas de revisión de literatura, construcción y validación del protocolo clínico. Este protocolo fue estructurado en 10 tópicos a partir de la recomendación de las directrices metodológicas para la elaboración de protocolos clínicos del Ministerio de Salud, evaluado por enfermeros especialistas considerando los temas de claridad, coherencia, relevancia y completitud. Resultados: Los contenidos fueron estructurados en torno al uso de pañales desechables con cambios frecuentes, uso de productos adecuados para la higiene y aplicación de productos para la protección de la piel, conforme a lo recomendado por la literatura, además del empleo de la Laserterapia de Baja Intensidad como tratamiento adyuvante. El índice de validación de contenido para cada tópico verificado varió entre 91,6% y 100%. Conclusión: El protocolo clínico fue considerado válido para el tratamiento de dermatitis asociadas a la incontinencia en el contexto pediátrico.Gabriela Beims Gapski; Juliana Balbinot Reis Girondi; Jane Cristina Anders; Kelli Borges dos Santos; Anna Julia Trindade Bittencourt

Oral cavity; Context (archaeology); Fish <Actinopterygii>; Seborrhoeic dermatitis; Medicine; Gynecology; Humanities

2026-01-01https://doi.org/10.1590/ce.v31i0.99330esCogitare Enfermagem 20261Ergonomia e saúde do(a) trabalhador(a) rural: construção participativa de cartilha educativa para profissionais da Atenção Primária à SaúdeObjetivo: Narrar a experiência de construção de uma cartilha sobre orientações de ergonomia no trabalho rural para profissionais de saúde da Estratégia Saúde da Família. Descrição da experiência: Realizou-se diagnóstico situacional participativo em uma Unidade Básica de Saúde rural no interior de Minas Gerais, revelando “alta frequência de dor crônica entre trabalhadores(as) rurais” e “dificuldade dos profissionais de saúde em promover orientações preventivas aos usuários”. Propôs-se, então, a construção de material educativo sobre ergonomia no trabalho rural para capacitar profissionais de saúde da Estratégia de Saúde da Família na realização de ações de prevenção, promoção e cuidado. O conteúdo foi selecionado por levantamento bibliográfico nas bases de dados Lilacs, Medline/Pubmed e Scielo. Foram incluídos no conteúdo 8 dos 139 estudos publicados nos últimos cinco anos, com livre acesso, que abordaram a temática. A cartilha foi estruturada em 25 páginas, com 8 domínios, incluindo informações sobre conceito de ergonomia, especificidades do trabalho rural e educação postural. Figuras e QR Code para vídeo explicativo disponível online foram incluídos. Conclusão: A cartilha apresentou potencial para aprendizagem sobre ergonomia no trabalho rural entre profissionais de saúde da Estratégia de Saúde da Família, replicabilidade em outros contextos similares e impacto social no território. A próxima etapa consiste em validar a cartilha por especialistas e pelo público-alvo e em realizar ações de educação permanente sobre o tema com os profissionais de saúde do território, visando à prevenção da dor crônica e a promoção da saúde no contexto campesino.Daniel Madeira Cardoso; Letícia dos Reis Nunes; Beatriz De Almeida Berbet; L Bonomo; Lélia Cápua Nunes

Work (physics); Service (business); Unit (ring theory); Context (archaeology); Rural area; Sociology; Humanities; Psychology; Pedagogy

2026-04-03https://doi.org/10.18310/2446-4813.2026v12nsup3.4904Saúde em Redes 20261Núcleo de dissertação e o programa de Pós-Graduação em gestão e avaliação da educação pública (ppgp): 15 anos de uma iniciativa inovadoraEste artigo relata a experiência de 15 anos do Núcleo de Dissertação, uma iniciativa pedagógica e de gestão do Programa de Pós-Graduação Profissional em Gestão e Avaliação da Educação Pública (PPGP), da Universidade Federal de Juiz de Fora (UFJF). O objetivo é apresentar o papel dessa equipe multidisciplinar no suporte a mestrandos e a orientadores no desenvolvimento de pesquisas, em um programa de alcance nacional e internacional que já totalizou 1.525 dissertações defendidas. A metodologia de trabalho do Núcleo, composto por mestres, doutorandos e doutores, baseia-se em um acompanhamento contínuo e pormenorizado das pesquisas, que se somam à orientação do professor responsável. A estrutura de apoio contempla leituras quinzenais, reuniões e interações via plataforma Moodle, sendo crucial no formato híbrido do curso. A dissertação possui formato específico, culminando em um Plano de Ação Educacional (PAE) que articula pesquisa e intervenção na realidade profissional do discente. Os resultados, corroborados por depoimentos de egressos, indicam que o modelo é inovador e eficaz, com a equipe assumindo funções de tutoria e mentoria essenciais para alunos-profissionais. Conclui-se que o Núcleo de Dissertação se consolidou como um modelo de sucesso para a orientação conjunta de mestrandos em larga escala, potencializando a missão do Programa de formar docentes e gestores para a transformação da educação pública brasileiraCassiano Caon Amorim; Juliana Alves Magaldi

Work (physics); Context (archaeology); Multidisciplinary approach; Government (linguistics); Field (mathematics); Humanities; Political science; Sociology

2026-04-05https://doi.org/10.5281/zenodo.19424151Zenodo (CERN European Organization for Nuclear Research) 20261UMA EDUCADORA ENTRE FRONTEIRASA interculturalidade e a internacionalização têm suscitado relevantes debates para a educação. Nesta entrevista, a professora e pesquisadora argentina Gracia María Clérico revisita momentos de seu percurso acadêmico-profissional e analisa como eventos aparentemente casuais e imprevistos contribuíram para a constituição de seu interesse pelas temáticas. Inicialmente envolvida em trabalhos com pessoas migrantes na Argentina e na Espanha, Clérico encontra no conceito fenomenológico de experiência elementar um fundamento teórico-metodológico que guia suas práticas de ensino e pesquisa universitária. A entrevistada também explicita seu posicionamento frente aos estudos culturais e discute criticamente os conceitos de multiculturalismo e assimilacionismo, defendendo a interculturalidade por meio de exemplos de práticas escolares que abrangem desde a educação básica até o ensino superior. Mais recentemente, destaca-se sua participação na Rede de Promoção da Interculturalidade na Internacionalização da Educação, que reúne pesquisadores brasileiros e argentinos em atividades de docência compartilhada. A entrevista conclui apontando possibilidades e desafios da educação intercultural e da cooperação acadêmica internacional na atualidade.Gracia Mária Clérico; Rodolfo Luís Leite Batista; Joana Falco Leão Oliveira; Maria Fernanda Justino de Oliveira

Subject (documents); Perspective (graphical); Order (exchange); Philosophy; Humanities; Sociology

2026-04-01https://doaj.org/article/25c6d122f4f549da855290bd0eb22416DOAJ (DOAJ: Directory of Open Access Journals) 20261Maximum Clique Detection via Second-Order Local Statistics Theoretical and Experimental Analysis on DIMACS BenchmarksWe present a polynomial-time algorithm for the Maximum Clique Problem (MCP) based on second-order local statistics (common neighborhood intersections), now extended to five phases (0–4). The algorithm finds optimal solutions on 33 of the 38 DIMACS benchmark instances with proven or best-known optima (86.8%), achieving 100% success on all pure random graphs G(n, p), all adversarial degree-compensated instances (brock family, 100%), all regular algebraic instances (hamming10-4, 100%), and 60% of planted clique instances. On the three large open instances without proven optima (C500.9, C1000.9, and C2000.9), it reaches solutions within 1–5 vertices of the current best-known values. Two new algorithmic phases are introduced: Phase 3 (ratio-slice exploration) detects distributional asymmetry in the restricted-degree profile within cells without any external knowledge of graph type, resolving brock800 (gap 0) and hamming10-4 (gap 0); Phase 4 (swap chain refinement) traverses the local neighborhood of the solution in swap space via iterative 1→1 swaps, resolving gen200_p0.9_44 (gap 0). We develop a quantitative theoretical model centered on the difficulty metric ρ = ω/√(p²n), classifying instances into three distinct regimes with provably different failure mechanisms: Regime 1 (ρ ≲ 1.5, guaranteed exact recovery via martingale analysis), Regime 2 (ρ > 1.5, accumulated greedy error partially corrected by local swaps), and Regime 3 (adversarial calibration that destroys all polynomial local signals). Formal results include a correctness theorem for Regime 1 (Theorem 6.6), a calibration barrier theorem (Theorem 6.9), correction capacity bounds (Theorem 6.11), a negative result on multi-scale block sampling (Theorem 6.15), and an asymptotic tractability conjecture (Conjecture 6.14). Fourteen partial formal results toward Conjecture 6.14 are presented in Appendix E (F.1–F.14), establishing equivalence to the Grimmett–McDiarmid (1975) gap, open for 50 years, and proving that greedy errors follow a Poisson distribution in the tractable regime (F.14, verified by Monte Carlo). The algorithm runs in O(p³n⁴ log n) worst-case time with bitset optimizations and exhibits empirical O(n³ log n) behavior on DIMACS instances. A complete, deterministic C implementation (~700 LOC), all experimental data, and proofs are provided.Wlymarvin Santos Oliveira

Correctness; Local optimum; Clique; Greedy algorithm; Graph; Matroid; Conjecture; Set packing; Linear programming; Swap (finance); Mathematics; Mathematical optimization; Discrete mathematics; Algorithm; Pointwise; Random graph; Algebraic connectivity; Benchmark (surveying); Generalization

2026-04-04https://doi.org/10.5281/zenodo.19423600Zenodo (CERN European Organization for Nuclear Research) 20261Núcleo de dissertação e o programa de Pós-Graduação em gestão e avaliação da educação pública (ppgp): 15 anos de uma iniciativa inovadoraEste artigo relata a experiência de 15 anos do Núcleo de Dissertação, uma iniciativa pedagógica e de gestão do Programa de Pós-Graduação Profissional em Gestão e Avaliação da Educação Pública (PPGP), da Universidade Federal de Juiz de Fora (UFJF). O objetivo é apresentar o papel dessa equipe multidisciplinar no suporte a mestrandos e a orientadores no desenvolvimento de pesquisas, em um programa de alcance nacional e internacional que já totalizou 1.525 dissertações defendidas. A metodologia de trabalho do Núcleo, composto por mestres, doutorandos e doutores, baseia-se em um acompanhamento contínuo e pormenorizado das pesquisas, que se somam à orientação do professor responsável. A estrutura de apoio contempla leituras quinzenais, reuniões e interações via plataforma Moodle, sendo crucial no formato híbrido do curso. A dissertação possui formato específico, culminando em um Plano de Ação Educacional (PAE) que articula pesquisa e intervenção na realidade profissional do discente. Os resultados, corroborados por depoimentos de egressos, indicam que o modelo é inovador e eficaz, com a equipe assumindo funções de tutoria e mentoria essenciais para alunos-profissionais. Conclui-se que o Núcleo de Dissertação se consolidou como um modelo de sucesso para a orientação conjunta de mestrandos em larga escala, potencializando a missão do Programa de formar docentes e gestores para a transformação da educação pública brasileiraCassiano Caon Amorim; Juliana Alves Magaldi

Work (physics); Context (archaeology); Multidisciplinary approach; Government (linguistics); Field (mathematics); Humanities; Political science; Sociology

2026-04-05https://doi.org/10.5281/zenodo.19424150Zenodo (CERN European Organization for Nuclear Research) 20261CLAREAMENTO DENTAL: SEGURANÇA E DURABILIDADE NAS TÉCNICAS ESTÉTICAS CONTEMPORÂNEASO clareamento dental constitui um dos procedimentos mais realizados na odontologia estética contemporânea, devido à crescente demanda social por tratamentos conservadores capazes de melhorar a aparência do sorriso com relativa previsibilidade clínica. O presente estudo teve como objetivo analisar criticamente a segurança e a durabilidade das principais técnicas de clareamento dental em dentes vitais, com ênfase nas modalidades realizadas em consultório e no clareamento domiciliar supervisionado, bem como nos agentes clareadores mais empregados, especialmente o peróxido de hidrogênio e o peróxido de carbamida. Adotou-se como método uma revisão sistemática da literatura, estruturada segundo princípios do PRISMA 2020 e baseada na busca e seleção crítica de revisões sistemáticas, ensaios clínicos randomizados e estudos clínicos longitudinais relacionados à eficácia, sensibilidade dental, estabilidade de cor e manejo clínico dos efeitos adversos. Os achados indicam que tanto o clareamento em consultório quanto o domiciliar supervisionado são efetivos para promover alteração cromática clinicamente perceptível, embora apresentem perfis distintos de tempo de resposta, conforto clínico e risco de sensibilidade. O clareamento em consultório, geralmente realizado com peróxido de hidrogênio em maiores concentrações, oferece resultados mais rápidos, porém associa-se com maior frequência à sensibilidade dental transitória. Já o clareamento domiciliar supervisionado, especialmente com peróxido de carbamida em concentrações moderadas, tende a apresentar bom desempenho clínico, menor intensidade de desconforto e estabilidade satisfatória ao longo do tempo. A literatura também demonstra que a concentração do agente, o tempo de aplicação, a integridade do esmalte, a presença de recessão gengival, os hábitos alimentares e o consumo de substâncias cromogênicas influenciam diretamente o sucesso terapêutico e a manutenção dos resultados. Conclui-se que o clareamento dental é um procedimento seguro e eficaz quando indicado de forma individualizada, planejado com base em evidências científicas e executado sob supervisão profissional. A durabilidade dos resultados depende não apenas da técnica empregada, mas também da adesão do paciente às recomendações de manutenção, ao controle dos fatores extrínsecos de pigmentação e ao acompanhamento odontológico periódico. Reforça-se, assim, o papel do cirurgião-dentista na avaliação diagnóstica, na seleção do protocolo mais apropriado e na condução ética das expectativas estéticas do paciente.Werônica Jaernevay Silveira Mitterhofer; José Daniel Carvalho Da Silva; Eduardo Cinel Agostineli; Aimée Maria Guiotti; Geovanna Sousa de Oliveira

Materials testing; Physics; Humanities

2026-04-06https://doi.org/10.70773/revistatopicos/775409313Revista Tópicos. 20261Reabilitação oral por meio de ancoragem zigomática: relato de casoA perda de elementos dentários desencadeia um processo contínuo de reabsorção óssea na maxila, caracterizado por redução volumétrica progressiva, sobretudo no componente medular, culminando em comprometimento tridimensional do rebordo alveolar. Tal condição impõe limitações significativas ao planejamento e à execução de terapias reabilitadoras com implantes osseointegráveis convencionais, especialmente em casos de atrofia moderada a severa. Nesse contexto, os protocolos que envolvem implantes de ancoragem zigomática, associados ou não a implantes convencionais, configuram-se como alternativas terapêuticas viáveis para a reabilitação de maxilas com perda estrutural avançada, ao possibilitarem ancoragem em estruturas ósseas de maior densidade e estabilidade biomecânica.O presente estudo tem por objetivo descrever, por meio de relato de caso clínico, o protocolo terapêutico empregado na reabilitação de uma maxila atrófica mediante a instalação de quatro implantes zigomáticos submetidos a protocolo de carga imediata, com acompanhamento clínico e radiográfico pelo período de seis meses. Ao longo do follow-up, todos os implantes demonstraram parâmetros clínicos e imaginológicos compatíveis com adequada osseointegração, não sendo observadas intercorrências patológicas.Os achados sugerem a previsibilidade e a efetividade da técnica empregada, destacando-se que, no caso apresentado, não houve necessidade de intervenções reconstrutivas prévias da maxila atrófica para viabilizar a reabilitação implantossuportada.Marcelo Gabriel de Oliveira; Isis Garcia Dias Ferreira; Thiago Borges Mattos; Lídia Batista Conrado Martins; Paola Ferreira Galito; Ive Couto

Oral surgery; Oral cavity; Context (archaeology); Tongue; Medicine; Gynecology

2026-04-06https://doi.org/10.52641/cadcajv11i4.2004Cadernos Cajuína 20261Search for electroweak <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"> <mml:mi>t</mml:mi> <mml:mover accent="true"> <mml:mi>t</mml:mi> <mml:mo stretchy="false">¯</mml:mo> </mml:mover> <mml:mi>W</mml:mi> <mml:mi>j</mml:mi> </mml:math> production in multileptonic final states at <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"> <mml:msqrt> <mml:mi>s</mml:mi> </mml:msqrt> <mml:mo>=</mml:mo> <mml:mn>13</mml:mn> <mml:mtext> </mml:mtext> <mml:mtext> </mml:mtext> <mml:mi>TeV</mml:mi> </mml:math> with the ATLAS detector and bounds on effective field theory operatorsA search is presented for the electroweak production of a top-quark pair in association with a <a:math xmlns:a="http://www.w3.org/1998/Math/MathML" display="inline"> <a:mi>W</a:mi> </a:math> boson and at least one additional jet known as the <c:math xmlns:c="http://www.w3.org/1998/Math/MathML" display="inline"> <c:mi>t</c:mi> <c:mover accent="true"> <c:mi>t</c:mi> <c:mo stretchy="false">¯</c:mo> </c:mover> <c:mi>W</c:mi> <c:msub> <c:mi>j</c:mi> <c:mi>EW</c:mi> </c:msub> </c:math> process. This process has embedded within it a <g:math xmlns:g="http://www.w3.org/1998/Math/MathML" display="inline"> <g:mi>t</g:mi> <g:mi>W</g:mi> </g:math> -scattering vertex, which is probed directly for the first time. The collision data were collected with the ATLAS detector during Run 2 of the LHC and correspond to an integrated luminosity of <i:math xmlns:i="http://www.w3.org/1998/Math/MathML" display="inline"> <i:mn>140</i:mn> <i:mtext> </i:mtext> <i:mtext> </i:mtext> <i:msup> <i:mi>fb</i:mi> <i:mrow> <i:mo>−</i:mo> <i:mn>1</i:mn> </i:mrow> </i:msup> </i:math> at <k:math xmlns:k="http://www.w3.org/1998/Math/MathML" display="inline"> <k:msqrt> <k:mi>s</k:mi> </k:msqrt> <k:mo>=</k:mo> <k:mn>13</k:mn> <k:mtext> </k:mtext> <k:mtext> </k:mtext> <k:mi>TeV</k:mi> </k:math> . The search uses same-charge pairs of electrons and muons together with jets, of which at least one is <m:math xmlns:m="http://www.w3.org/1998/Math/MathML" display="inline"> <m:mi>b</m:mi> </m:math> -tagged. The properties of the most forward jet relative to the rest of the event are used to discriminate the electroweak <o:math xmlns:o="http://www.w3.org/1998/Math/MathML" display="inline"> <o:mi>t</o:mi> <o:mover accent="true"> <o:mi>t</o:mi> <o:mo stretchy="false">¯</o:mo> </o:mover> <o:mi>W</o:mi> <o:msub> <o:mi>j</o:mi> <o:mi>EW</o:mi> </o:msub> </o:math> production process from its strong <s:math xmlns:s="http://www.w3.org/1998/Math/MathML" display="inline"> <s:mi>t</s:mi> <s:mover accent="true"> <s:mi>t</s:mi> <s:mo stretchy="false">¯</s:mo> </s:mover> <s:mi>W</s:mi> </s:math> production counterpart. A measured (expected) 95% CL upper limit on the cross section is set at <w:math xmlns:w="http://www.w3.org/1998/Math/MathML" display="inline"> <w:msub> <w:mi>σ</w:mi> <w:mrow> <w:mi>t</w:mi> <w:mover accent="true"> <w:mi>t</w:mi> <w:mo stretchy="false">¯</w:mo> </w:mover> <w:mi>W</w:mi> <w:msub> <w:mi>j</w:mi> <w:mi>EW</w:mi> </w:msub> </w:mrow> </w:msub> <w:mo><</w:mo> <w:mn>251</w:mn> <w:mtext> </w:mtext> <w:mtext> </w:mtext> <w:mi>fb</w:mi> </w:math> (230 fb), to be compared with the expected Standard Model (SM) cross section of 47.7 fb. Limits are set on the SM effective field theory (EFT) operators <ab:math xmlns:ab="http://www.w3.org/1998/Math/MathML" display="inline"> <ab:msub> <ab:mi>O</ab:mi> <ab:mrow> <ab:mi>H</ab:mi> <ab:mi>t</ab:mi> </ab:mrow> </ab:msub> </ab:math> and <cb:math xmlns:cb="http://www.w3.org/1998/Math/MathML" display="inline"> <cb:msubsup> <cb:mi>O</cb:mi> <cb:mrow> <cb:mi>H</cb:mi> <cb:mi>Q</cb:mi> </cb:mrow> <cb:mrow> <cb:mo stretchy="false">(</cb:mo> <cb:mn>1</cb:mn> <cb:mo stretchy="false">)</cb:mo> </cb:mrow> </cb:msubsup> </cb:math> , which modify the electroweak couplings of the top quark through contributions to the <gb:math xmlns:gb="http://www.w3.org/1998/Math/MathML" display="inline"> <gb:mi>t</gb:mi> <gb:mi>W</gb:mi> </gb:math> -scattering vertex. The interpretation acts as a case study to emphasize the importance of energy-dependent sensitivity, multiprocess, and multioperator EFT contributions.Anonymous; E. Aakvaag; B. Abbott; S. Abdelhameed; K. Abeling; N. J. Abicht; S. H. Abidi; M. Aboelela; A. Aboulhorma; H. Abramowicz; Y. Abulaiti; B. S. Acharya; A. Ackermann; C. Adam Bourdarios; L. Adamczyk; S. V. Addepalli; M. J. Addison; J. Adelman; A. Adiguzel; T. Adye; A. A. Affolder; Y. Afik; M. N. Agaras; A. Aggarwal; C. Agheorghiesei; F. Ahmadov; S. Ahuja; S. Ahuja; X. Ai; G. Aielli; A. Aikot; M. Ait Tamlihat; B. Aitbenchikh; T. P. A. Åkesson; A. V. Akimov; D. Akiyama; N. N. Akolkar; S. Aktas; G. L. Alberghi; J. Albert; U. Alberti; P. Albicocco; G. L. Albouy; S. Alderweireldt; Z. L. Alegria; M. Aleksa; I. N. Aleksandrov; C. Alexa; T. Alexopoulos; F. Alfonsi; M. Algren; M. Alhroob; B. Ali; H. M. J. Ali; S. Ali; S. W. Alibocus; M. Aliev; G. Alimonti; W. Alkakhi; C. Allaire; B. M. M. Allbrooke; D. R. Allen; J. S. Allen; J. F. Allen; P. P. Allport; A. Aloisio; F. Alonso; C. Alpigiani; Z. M. K. Alsolami; A. Alvarez Fernandez; M. Alves Cardoso; M. G. Alviggi; M. Aly; Y. Amaral Coutinho; A. Ambler; C. Amelung; M. Amerl; C. G. Ames; T. Amezza; D. Amidei; B. Amini; K. Amirie; A. Amirkhanov; S. P. Amor Dos Santos; K. R. Amos; D. Amperiadou; S. An; C. Anastopoulos; T. Andeen; J. K. Anders; A. C. Anderson; A. Andreazza; S. Angelidakis; A. Angerami; A. V. Anisenkov; A. Annovi; C. Antel; E. Antipov; M. Antonelli; F. Anulli

Production (economics); Electroweak interaction; Standard Model (mathematical formulation); Action (physics); Technicolor; Physics; Particle physics; Computer science

2026-04-06https://doi.org/10.1103/p5nz-95m3Physical review. D/Physical review. D. 20261PLN e Responsabilidade Social Aplicações da FrameNet-BrMaucha Andrade Gamonal; Lívia Vicente Dutra; Mariane de Carvalho Pinto; Tiago Timponi Torrent

Government (linguistics); Context (archaeology); Production (economics); Agency (philosophy); Political science; Economics; Business

2026-04-16https://doi.org/10.5281/zenodo.19440740Zenodo (CERN European Organization for Nuclear Research) 20261A Geometric-Combinatorial Approach to the Constructing Fractals with Cubic SymmetryIntroduction. An iterative geometric-combinatorial approach to the construction of fractals with cubic symmetry — cubofractals — is proposed, adapted for their subsequent physical implementation. A connection between the introduced cubofractals and attractors of non-stationary iterated function systems is established. Two examples of cubofractals are studied, the attractors of the corresponding iterated function systems are determined, and their Hausdorff dimensions are computed. In applied physics and materials science, fractal models can be successfully used to describe the hierarchical structure of new materials. However, perfect self-similarity at all scales is not observed in real systems. When synthesizing fractal-like structures, a minimum scale and basic structural elements that combine at higher hierarchical levels can often be identified. In this work, the authors employ this very approach to construct cubofractals. Materials and Methods. The proposed approach is close to constructing fractals using L -systems; however, even the simple cube arrangement rules considered by the authors require context-sensitive rules. This work establishes a connection between the considered generation algorithms and a non-stationary generalization of iterated function systems. Thus, the study of the limit transitions from prefractals to fractals is conducted within the framework of the theory of contractive mappings. The corresponding non-stationary iterated function systems are implemented in Wolfram Mathematica (the appendix provides code for the generation and visualization of cubofractals). Results. The adequacy and simplicity of the cubofractal generation algorithm for creating corresponding structures are demonstrated. A connection with the mathematical apparatus of non-stationary iterated function systems is established. Variants of cubofractal generation rules are studied, and different classes of the resulting structures are identified. Pointwise limits of cubofractal iterations and the limit transition in the Hausdorff metric are investigated. It is shown that by choosing a sequence a n+1 with a given growth rate and its partitioning into Ra n and ∆ n , we can control the iteration measure and the Hausdorff dimension of the limit. For two basic examples of cubo-fractals with sequences a n = n ∙2 n-1 + 2, n > 0 (cubosixter) and a n = 1+ 8∙5 n-2 , n > 1 we calculated the fractal dimensions 1 and ln3/ln5, respectively. Backward trajectories of non-stationary systems of iterated functions are considered, and an approach to studying their attractors is proposed. Discussion. Cubofractals can provide a convenient approach for generating fractal structures for applications and, furthermore, they significantly enrich the theory of non-stationary iterated function systems with non-trivial examples. Conclusion. The limit set of the cubosister is simply the segment [0;1], while the measure of the finite iterations, which approach the segment in the sense of the Hausdorff metric, tends to zero. It can be assumed that other physical properties of the iterations (mass, strength, porosity, etc.) will also differ in the pointwise limit and in the limit in the sense of the Hausdorff metric. In this regard, it is the prefractals for the cubosister that are of research interest in applications.E. V. Kravchenko; A. M. Pupasov-Maksimov; M. A. Merzlikin

Iterated function system; Fractal; Connection (principal bundle); Attractor; Iterated function; Generalization; Function (biology); Symmetry (geometry); Mathematics; Simple (philosophy); Hausdorff distance; Discrete mathematics; Algorithm; Completeness (order theory); Dissipative system

2026-04-02https://doi.org/10.23947/2587-8999-2026-10-1-72-83COMPUTATIONAL MATHEMATICS AND INFORMATION TECHNOLOGIES 20261PLN e Responsabilidade Social Aplicações da FrameNet-BrMaucha Andrade Gamonal; Lívia Vicente Dutra; Mariane de Carvalho Pinto; Tiago Timponi Torrent

Government (linguistics); Context (archaeology); Production (economics); Agency (philosophy); Political science; Economics; Business

2026-04-16https://doi.org/10.5281/zenodo.19440739Zenodo (CERN European Organization for Nuclear Research) 20261Premature Infants With Pulmonary Complications Exhibit Decreased Skin Maturity Early After Birth: A Cross‐Sectional StudyINTRODUCTION: Early identification of respiratory risk in preterm newborns (PTNB) remains challenging, as direct assessment of pulmonary maturity is often unavailable or requires invasive or resource-intensive methods. Non-invasive biomarkers capable of indicating physiological maturity shortly after birth could improve early clinical decision-making in neonatal care. Because skin and lung development share common biological pathways, skin maturity assessed by optical reflectance may serve as an indirect marker of pulmonary development. OBJECTIVE: This study evaluated the association between skin maturity estimated by skin reflectance and respiratory outcomes in PTNB during the first 48 hours of life. METHODS: A cross-sectional study was conducted with PTNB born admitted within 48?h. Exclusion criteria included cutaneous malformations, or conditions interfering with dermal assessment. Skin maturity was measured using the non-invasive Preemie-Test® device. Respiratory outcomes, such as chest radiographic abnormalities, pneumothorax, atelectasis, and pulmonary hemorrhage, were defined by clinical and radiological criteria. RESULTS: A total of 82 PTNB were included, 54.9% male. Skin reflectance ranged from 0.9 to 2.1?nm. Lower skin maturity was significantly associated with radiographic abnormalities (p = 0.01), pneumothorax (p = 0.01), pulmonary hemorrhage (p = 0.01), atelectasis (p = 0.01), and need for invasive ventilation (p = 0.01). CONCLUSIONS: These findings suggest skin reflectance may serve as a rapid, objective, and non?invasive screening tool for neonatal respiratory risk.Samanta Cris Monteiro Frota; Luiza Eduarda Silva de Macedo; Larissa Queiroz Oliveira; Ingrid Fonsêca Damasceno Bezerra; Anna Christina do Nascimento Granjeiro Barreto; Ingrid Guerra Azevedo; Roberta Lins Gonçalves; Daniele Soares‐Marangoni; Gabriela Silveira Neves; Carolina Daniel de Lima‐Alvarez; Silvana Alves Pereira

Respiratory system; Bronchopulmonary dysplasia; Respiratory disease; Skin color; Skin barrier; Maturity (psychological); Medicine; Pediatrics

2026-04-01https://doi.org/10.1002/ppul.71562Pediatric Pulmonology 20261Learning Environment, Academic Stressors, and Institutional Aspects as Determinants of Mental Health Outcomes in Medical EducationOBJECTIVE: Examine associations between learning environment, academic stressors, and mental health among Brazilian medical students across different institutional contexts. METHODS: Cross-sectional study of 1,026 medical students from 74 public and private universities. Participants completed the Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder-7 (GAD-7), Johns Hopkins Learning Environment Scale (JHLES), and Medical Student Stressor Factor Scale (MSSF). Analyses included group comparisons, multiple regression, random forest modeling, and latent class analysis. RESULTS: Private university students reported significantly better learning environments than public university counterparts (M = 84.6 vs. 81.9, p < 0.001). Quota students, those admitted to universities through affirmative action policies, demonstrated higher depression scores (M = 14.2 vs. 12.8, p = 0.007) and academic stress levels (M = 134.0 vs. 129.1, p = 0.018). Academic stressors demonstrated significant associations with both depressive (β=0.103; p<0.001) and anxiety symptoms (β=0.103; p<0.001), while higher learning environment quality was associated with lower depressive symptom severity (β=-0.105; p=0.043). Latent classes identified high-risk (53.7%), moderate-distress (32.7%), and high-functioning (13.6%) profiles, with affirmative-action students overrepresented in higher-risk classes. CONCLUSION: Students admitted via affirmative action in public universities face compounded vulnerabilities. Interventions should focus on reducing academic stress and improving learning environments, especially in public institutions serving disadvantaged groups.Clarissa Garcia Custódio; Lilian Cristie de Oliveira; Laura Fernandes Berto; Bianca Besteti Fernandes Damiano; Juliane Piasseschi de Bernardin Gonçalves; Oscarina da Silva Ezequiel; Alessandra Lamas Granero Lucchetti; Lisabeth F. DiLalla; Homero Vallada; Euripedes Constantino Miguel; Giancarlo Lucchetti; Rodolfo Furlan Damiano

Mental health; MEDLINE; Psychological intervention; Mental illness; Continuing medical education; Higher education; Medical education; Psychology; Nursing; Medicine

2026-01-01https://doi.org/10.47626/1516-4446-2025-4509Brazilian Journal of Psychiatry 20261Determination of turbidity in a drinking water reservoir from UV-Vis absorption spectra with multivariate modelingDataset containing limnological measurements from a freshwater system. Data were collected across different depths and sampling points to assess spatial variability and its relationship with low concentrations of suspended particles.Patricia Fernanda dos Santos de Loureiro Nunes

Turbidity; Sampling (signal processing); Hydrology (agriculture); Water reservoir; Multivariate statistics; Water quality; Environmental science; Spatial variability; Water pollution; Surface water; Absorption (acoustics); Turbidite

2026-04-07https://doi.org/10.5281/zenodo.19457974Zenodo (CERN European Organization for Nuclear Research) 20261Integração da Classificação Molecular e Histopatológica: Um Caminho para Otimizar o Tratamento e o Prognóstico no Câncer de EndométrioIntrodução: O câncer de endométrio, sexta neoplasia mais comum em mulheres pós-menopausa, apresenta incidência crescente globalmente. Tradicionalmente, é classificado em tipos I (endometrioide) e II (não endometrioide) e, mais recentemente, em quatro grupos moleculares, com diferentes implicações prognósticas e terapêuticas. Objetivo: Analisar o impacto da integração entre histopatologia e biologia molecular na compreensão do câncer de endométrio e sua influência no tratamento e prognóstico das pacientes. Método: Estudo retrospectivo de 1.451 casos do projeto The Cancer Genome Atlas (TCGA), utilizando ANOVA, teste t e qui-quadrado para avaliação genômica e clínica. Resultados: O carcinoma endometrioide foi predominante, com média de idade ao diagnóstico de 63,7 anos e sobrevida global variando por raça. A radioterapia adjuvante mostrou-se eficaz em pacientes com carcinoma endometrioide, com sobrevida global de 35,4 meses. A terapia neoadjuvante aumentou significativamente a sobrevida global em carcinomas serosos papilares uterinos. Puderam se beneficiar da análise molecular 87% das pacientes com carcinoma endometrioide, 48% com carcinoma misto endometrial e 25% com carcinoma endometrial indiferenciado. Os grupos moleculares apresentaram características distintas de expressão gênica. As do Grupo 1 sugeriram controle dinâmico da doença. No Grupo 2, predominaram genes ligados ao ciclo celular e estabilidade da cromatina. O Grupo 3 destacou genes envolvidos no remodelamento da cromatina e proliferação celular, enquanto o Grupo 4 caracterizou-se pela expressão de TP53 e de genes relacionados à via PI3K-AKT. Conclusão: Dada a complexidade molecular do câncer de endométrio, integrar análises histopatológicas e moleculares é essencial para guiar tratamentos precisos, aumentando a eficácia terapêutica e melhorando desfechos clínicos.Eliane Gouvêa de Oliveira-Barros; Guilherme Tavares Cruz; Maria Bethânia Souza Vilela; Gabriela Silva Castro; Jéssica Menezes do Nascimento; Larissa Marques Gonçalves; OLGA MARIA SILVA CASTRO; Anna Marcella Neves Dias; Nathália Barbosa do Espírito Santo Mendes; Bruno Aquino Marcelino

Carcinoma; Radiation therapy; Cancer; Human papillomavirus; Gynecology; Medicine; Molecular biology

2026-04-07https://doi.org/10.32635/2176-9745.rbc.2026v72n2.5689Revista Brasileira de Cancerologia 20261Paired METAR/SPECI Dataset and Analysis Code — Remote Aerodrome Flight Information Service Shadow-Mode Validation at SBMI (2025)Dataset and Python analysis code supporting the article "Shadow-Mode Meteorological Concordance Between Remote and On-Site Observation at a Brazilian Regional Aerodrome" (Journal of Aerospace Technology and Management, manuscript JATM-2026-0039). Contains 749 paired METAR/SPECI messages from 118 operational days (17 March – 28 November 2025) at the SBMI aerodrome (Maricá, Rio de Janeiro, Brazil), and the scripts for the concordance analysis. Version 1.1 adds a script reproducing the Table 2 intraclass correlation coefficients (compute_icc.py), a transparent register of known data anomalies (data_anomalies.csv), and a README documenting workbook provenance and reproducibility; the supporting-article title is aligned and raw observational records are unchanged.Guilherme Vieira Monteiro Amadeu

Scripting language; Python (programming language); Service (business); Source code; Code (set theory); Computer science; Remote sensing; Real-time computing; Data mining; Meteorology; Database

2026-06-27https://doi.org/10.5281/zenodo.19462685Zenodo (CERN European Organization for Nuclear Research) 20261Perceptions of the Body in Cerebral Palsy: Voices of Family CaregiversBackground/Objectives: Cerebral palsy (CP) is the most prevalent physical disability in the pediatric population, resulting in functional limitations and restrictions in participation, with higher prevalence rates in low- and middle-income countries. Caregivers of children and adolescents with CP face both physical and emotional challenges, and their perceptions of the body may act as contextual and cultural indicators shaping children’s participation, care practices, and well-being within the family environment. This study aimed to understand the perceptions, values, and cultural beliefs of family caregivers about the bodies of children and adolescents with CP. Methods: A qualitative study was conducted using six focus groups with 22 mothers and grandmothers of children and adolescents with CP. Participants were recruited from rehabilitation services. Discussions were audio-recorded, transcribed verbatim, and analyzed using content analysis. The analytical process involved systematic coding, categorization, and thematic interpretation to identify recurring meanings and patterns across narratives. Results: Three thematic categories emerged: (1) perceptions of the body within social interactions; (2) viewing the body as capable of performing activities independently when stimulated/taught; and (3) viewing the body as dependent, requiring constant supervision and support. Conclusions: The findings highlight the need to expand family caregivers’ knowledge about CP to promote children’s participation and mitigate beliefs related to limitations, dependence, fragility, and vulnerability.Mariana Cristina Palermo Ferreira; Érica Cesário Defilipo; Lélia Cápua Nunes; Pedro Henrique Berbert de Carvalho

Perception; Thematic analysis; Cerebral palsy; Focus group; Family caregivers; Qualitative research; Rehabilitation; Psychology; Developmental psychology; Clinical psychology; Content analysis

2026-04-07https://doi.org/10.3390/healthcare14070967Healthcare 20261Determinação da variação do índice de refração da água em função de sua temperatura utilizando o interferômetro de MichelsonEste é o quinto capítulo do livro Pesquisas no Instituto de Ciências Exatas, Engenharias e Arquitetura – UFJF – volume 2, de DOI: 10.64521/ebook-978-65-80008-84-1. O capítulo apresenta o estudo da variação do índice de refração da água em função da temperatura, utilizando um interferômetro de Michelson como principal instrumento experimental.Ivan Ferreira Dos Santos; Wallon Anderson Tadaiesky Nogueira

Noise (video); Volume (thermodynamics); Feature (linguistics); Physics

2026-01-01https://doi.org/10.5281/zenodo.19457030Zenodo (CERN European Organization for Nuclear Research) 20261Determination of turbidity in a drinking water reservoir from UV-Vis absorption spectra with multivariate modelingDataset containing limnological measurements from a freshwater system. Data were collected across different depths and sampling points to assess spatial variability and its relationship with low concentrations of suspended particles.Patricia Fernanda dos Santos de Loureiro Nunes

2026-04-07https://doi.org/10.5281/zenodo.19457973Zenodo (CERN European Organization for Nuclear Research) 20261Fast reconstruction-based ROI triggering via anomaly detection in the CYGNO optical TPCAbstract Optical-readout time projection chambers (TPCs) produce megapixel-scale images whose fine-grained topological information is essential for rare-event searches, but whose size challenges real-time data selection. We present an unsupervised, reconstruction-based anomaly-detection strategy for fast region-of-interest (ROI) extraction that operates directly on minimally processed camera frames. A convolutional autoencoder (AE) trained exclusively on pedestal images learns the detector noise morphology without labels, simulation, or fine-grained calibration. Applied to standard data-taking frames, localized reconstruction residuals identify particle-induced structures, from which compact ROIs are extracted via thresholding and spatial clustering. Using real data from the CYGNO optical TPC prototype, we compare two pedestal-trained AE configurations that differ only in their training objective, enabling a controlled study of its impact. The best configuration retains <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" overflow="scroll"> <mml:mrow> <mml:mo stretchy="false">(</mml:mo> <mml:mn>93.0</mml:mn> <mml:mo>±</mml:mo> <mml:mn>0.2</mml:mn> <mml:mo stretchy="false">)</mml:mo> <mml:mi mathvariant="normal">%</mml:mi> </mml:mrow> </mml:math> of reconstructed signal intensity while discarding <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" overflow="scroll"> <mml:mrow> <mml:mo stretchy="false">(</mml:mo> <mml:mn>97.8</mml:mn> <mml:mo>±</mml:mo> <mml:mn>0.1</mml:mn> <mml:mo stretchy="false">)</mml:mo> <mml:mi mathvariant="normal">%</mml:mi> </mml:mrow> </mml:math> of the image area, with an inference time of ∼25 ms per frame on a consumer GPU. The results demonstrate that careful design of the training objective is critical for effective reconstruction-based anomaly detection and that pedestal-trained AEs provide a transparent and detector-agnostic baseline for online data reduction in optical TPCs.F D Amaro; R Antonietti; Elisabetta Baracchini; Luigi Benussi; Cesidio Capoccia; Michele Arturo Caponero; L G M de Carvalho; G Cavoto; I A Costa; A Croce; M D’Astolfo; Giulia D’Imperio; Giorgio Dho; E Di Marco; J M F dos Santos; Davide Fiorina; F Iacoangeli; Zahoor ul Islam; Ernesto Kemp; Herman P Lima Jr; Giovanni Maccarrone; R D P Mano; David José Gaspar Marques; Giovanni Mazzitelli; Pietro Meloni; A Messina; V Monno; C M B Monteiro; R A Nobrega; G M Oppedisano; Igor Fonseca Pains; E Paoletti; Fabrizio Petrucci; Stefano Piacentini; D Pierluigi; Davide Pinci; F Renga; A Russo; G Saviano; P A O C Silva; N J Spooner; Roberto Tesauro; Sandro Tomassini; Donatella Tozzi

Thresholding; Projection (relational algebra); Autoencoder; Noise reduction; Detector; Pattern recognition (psychology); Noise (video); Anomaly detection; Reduction (mathematics); Artificial intelligence; Computer science; Computer vision; Frame (networking); Feature extraction; Iterative reconstruction; Background subtraction; Block (permutation group theory); SIGNAL (programming language); Anomaly (physics); Background noise; Convolutional neural network; Signal-to-noise ratio (imaging); Image resolution

2026-04-01https://doi.org/10.1088/2632-2153/ae5c5bMachine Learning Science and Technology 20261Paired METAR/SPECI Dataset and Analysis Code — Remote Aerodrome Flight Information Service Shadow-Mode Validation at SBMI (2025)Dataset and Python analysis code supporting: Operational Validation of Remote Aerodrome Flight Information Service at a Regional Aerodrome: Meteorological Concordance in Shadow Mode. Contains 749 paired METAR/SPECI messages from 118 operational days (March–November 2025) at SBMI aerodrome, Brazil, and scripts for the concordance analysis.Guilherme Vieira Monteiro Amadeu

Scripting language; Python (programming language); Service (business); Source code; Code (set theory); Computer science; Remote sensing; Real-time computing; Data mining; Meteorology; Database

2026-04-08https://doi.org/10.5281/zenodo.19462686Zenodo (CERN European Organization for Nuclear Research) 20261Escola e escolarização de jovens e adultos: reflexões acerca das contribuições de Paulo Freire para a democratização da educação e da sociedade brasileiraO artigo analisa as contribuições de Paulo Freire para a escolarização de jovens e adultos. Busca compreender seu legado, fortalecendo o contexto de democratização da escola pública brasileira. Assim, teve como objetivos: situar a escola na concepção crítica de educação de Paulo Freire e analisar seus contributos para a escolarização de jovens e adultos. O artigo baseia-se na perspectiva histórico-dialética, tendo por referência a trajetória política, obras formuladas por Paulo Freire e produções acerca dos processos de escolarização de jovens e adultos. Considera-se que o legado freireano demonstra intrínseco compromisso com a democratização da sociedade e da escola pública brasileiras, pois combate os propósitos da educação bancária que se consolidaram por meio do ensino de suplência.Rubens Luiz Rodrigues

Context (archaeology); Work (physics); Perspective (graphical); Politics; Order (exchange); Sociology; Humanities; Philosophy

2026-03-16https://doi.org/10.21573/vol42n12026.144325Revista Brasileira de Política e Administração da Educação - Periódico científico editado pela ANPAE 20261Determinação da variação do índice de refração da água em função de sua temperatura utilizando o interferômetro de MichelsonEste é o quinto capítulo do livro Pesquisas no Instituto de Ciências Exatas, Engenharias e Arquitetura – UFJF – volume 2, de DOI: 10.64521/ebook-978-65-80008-84-1. O capítulo apresenta o estudo da variação do índice de refração da água em função da temperatura, utilizando um interferômetro de Michelson como principal instrumento experimental.Ivan Ferreira Dos Santos; Wallon Anderson Tadaiesky Nogueira

Noise (video); Volume (thermodynamics); Feature (linguistics); Physics

2026-01-01https://doi.org/10.5281/zenodo.19457029Zenodo (CERN European Organization for Nuclear Research) 20261Designing an affordable dip-coating systemFiles used in the development designing an affordable dip-coating system.Vinycios Moreira André; Rodrigo Alves Dias; Moyra Freitas Vieira; Christ Gohering Santos, Ramon; Camanho Costa, Guilherme; Izumi, Celly

Key (lock); Work (physics); Systems design; Information system; Computer science; Business; Systems engineering

2026-04-08https://doi.org/10.5281/zenodo.19472183Zenodo (CERN European Organization for Nuclear Research) 20261Para cada mal há um remédio? A medicalização do luto relacionada à pandemia da Covid-19Este artigo tem por objetivo discutir as experiências de mulheres atendidas na Atenção Primária à Saúde (APS), em relação ao luto e consumo de psicofármacos durante a pandemia da Covid-19. Para isso, foi realizado um breve retorno ao movimento de medicalização e sua expressão antecedente ao período pandêmico, com intuito de discutir como o medicamento psiquiátrico adentrou a realidade das pessoas e o lugar que ele passou a ocupar, seja como estratégia de manejo e cuidado em saúde mental ou mesmo de entendimento e vivência do processo de sofrimento que advém do luto. Fruto da dissertação da primeira autora, ancorada na pesquisa participante, possui relato das mulheres entrevistadas para a realização do trabalho. A inserção em campo se deu pela Atenção Primária à Saúde (APS), concomitantemente a realização de visitas domiciliares junto às Agentes Comunitárias de Saúde (ACS), realização de Roda de Conversa (RC), relato em Diário de Campo (DC) e caminhadas comunitárias, que levaram ao conhecimento das histórias de vida das mulheres convidadas a compor o estudo. Após a análise dos relatos, é possível conceber o lugar que o psicofármaco ocupa como estratégia de manejo do sofrimento, incluindo o que advém do processo de luto, e como a vivência de perdas durante a crise sanitária ainda está em processo de assimilação e entendimento. Palavras-chave: Pandemia, Covid-19, Psicotrópico, Gênero, Luto.Taynara Maria Batista; Fernando Santana de Paiva

Context (archaeology); Politics; Michel foucault; Humanities; Medicine

2026-03-30https://doi.org/10.7213/psicolargum.44.124.ao06Psicologia Argumento 20261Revisiting the modeling of cell electrophysiology using a delay-based equationAbstract Voltage-gated ion channels respond to the transmembrane voltage by transitioning among conduction states, thereby shaping macroscopic ionic currents and the voltage itself. Although microscopic gating is usually modeled as a memoryless Markov process, the resulting population-level conductances exhibit an effective dependence on the past transmembrane-voltage trajectory and can therefore be represented using discrete delays (Dirac kernels) or, more generally, Volterra memory kernels. In this study, we propose a simple mathematical model that describes the action potential using a single delay differential equation based on the conductances of sodium and potassium channels. Our model accurately reproduces the behavior of a standard Hodgkin–Huxley action potential, including the characteristic sodium and potassium conductance profiles. This framework captures essential electrophysiological features such as subthreshold and suprathreshold responses, and the all-or-nothing principle. Through this delay formulation, we derive explicit analytical approximations for strength-interval relations, expressing excitability recovery directly in terms of a small set of interpretable parameters. We also provide analytical expressions for the relation between spike frequency and the amplitude of a prolonged stimulus. Additionally, by changing the memory kernel, we connect the discrete-delay model to other representations of macroscopic channel memory, including linear-chain (Erlang) ODE approximations, Markov (CTMC) models, and fractional calculus formulations. This approach highlights the potential of delayed differential equations and memory kernels to capture essential neuronal dynamics.Noemi Zeraick Monteiro; Rodrigo Weber dos Santos

Gating; Ode; Action (physics); Electrophysiology; Ordinary differential equation; Hodgkin–Huxley model; Subthreshold conduction; Differential equation; Cable theory; Spike (software development); Mathematics; Membrane potential; Trajectory; Sodium channel; Control theory (sociology); Amplitude; Ion channel; Physics; Potassium channel; Biological system; Bursting; Conductance; Mathematical analysis; Cardiac electrophysiology

2026-04-01https://doi.org/10.1007/s11071-026-12392-0Nonlinear Dynamics 20261Cortical Timing Biomarkers of Psychomotor Dysfunction in Depressive Disorder: A Cross-Validated StudyBackground: Major Depressive Disorder (MDD) is increasingly recognized as involving psychomotor slowing and impaired cortical timing. Objective vibrotactile assessments can quantify sensory and cognitive integration, potentially identifying mechanistic biomarkers of depression. Objective: To determine whether tactile performance metrics from the Brain Gauge system differentiate individuals with depression from healthy controls and to identify the most predictive domains using cross-validated modeling. Methods: Eighty-two adults (43 with depression, 39 controls) completed the Brain Gauge battery assessing reaction time (RT), RT variability, amplitude and duration discrimination, temporal order judgment, accuracy, and cortical plasticity. Results: After FDR correction, participants with depression showed significantly slower and more variable tactile responses (FDR-adjusted p < 0.05). Speed and RT variability remained independent predictors (OR = 4.14; OR = 0.015), yielding an AUC = 0.86 (sensitivity = 0.87; specificity = 0.77). These findings suggest reduced cortical stability and efficiency in depression. Conclusions: Tactile timing measures—particularly Speed and RT variability—objectively capture psychomotor and temporal instability in MDD. Cross-validated logistic modeling supports their potential as non-invasive digital biomarkers for depression phenotyping and monitoring. These findings suggest tactile timing instability as a clinically relevant neurofunctional dimension of major depressive disorder, with potential applications in psychiatric phenotyping, objective symptom monitoring, and future precision-guided treatment strategies.Mayra Evelise dos Santos; Kariny Realino Ferreira; Sérgio T. Fonseca; Gabriela Lopes Gama; M. C. S. A. Barbosa; Alexandre Carvalho Barbosa

Psychomotor learning; Depression (economics); Major depressive disorder; Sensory system; Cognition; Logistic regression; Psychomotor agitation; Depressive symptoms; Medicine; Audiology; Neuroscience; Time perception; Psychomotor retardation; Physical medicine and rehabilitation; Biomarker; Electroencephalography; Psychology; Effects of sleep deprivation on cognitive performance

2026-04-08https://doi.org/10.3390/psychiatryint7020076Psychiatry International 20261INTERNAÇÕES E MORTALIDADE POR SEPSE NO BRASIL: ANÁLISE DA SÉRIE TEMPORAL DE 2014 a 2024A sepse é uma condição infecciosa grave caracterizada por disfunção orgânica e elevada morbimortalidade, permanecendo como uma das principais causas de hospitalização e óbito em unidades de terapia intensiva no Brasil e no mundo. Este trabalho teve como objetivo analisar as tendências temporais das internações por sepse no Brasil, descrever a distribuição dos casos segundo variáveis demográficas e regionais, bem como determinar e comparar as taxas de mortalidade e letalidade hospitalar ao longo da série histórica. O estudo do tipo série temporal ecológica foi baseado em dados secundários de internações hospitalares do Sistema Único de Saúde, disponíveis no DATASUS, no período de 2014 a 2024. Foram registradas 1.466.710 internações por sepse no Brasil, das quais 15,42% ocorreram no estado de Minas Gerais. Observou-se aumento progressivo das internações após o período pandêmico, com pico no ano de 2024. Houve predominância de casos no sexo masculino (52,2%), maior frequência entre indivíduos com idade entre 60 e 79 anos e maior ocorrência em pessoas autodeclaradas brancas, seguidas pelas pardas. A Região Sudeste concentrou mais da metade das internações e dos óbitos. No total, foram registrados 662.792 óbitos por sepse, resultando em uma letalidade de 45,18%, com taxas mais elevadas na Região Sudeste. A sepse permanece como importante causa de hospitalização e morte no Brasil, especialmente entre a população idosa. Os resultados evidenciam a necessidade de fortalecimento da vigilância epidemiológica, do diagnóstico precoce e da redução das desigualdades regionais na assistência hospitalar, visando à diminuição da mortalidade associada à sepse.Felipe Leocádio Pinheiro; Beatriz Vieira Garcia Valssis; André Luiz Silva Alvim; Danielle Andrade Ferreira; Patrícia Guedes Garcia

Intensive care; Septic shock; Incidence (geometry); Mortality rate; Medicine; Gynecology

2026-01-01https://doi.org/10.37885/260321348Editora Científica Digital eBooks 20261Atmosferas da Terra e de Marte: uma abordagem astrobiológicaEste artigo compara as atmosferas da Terra e de Marte sob a perspectiva astrobiológica, examinando evolução, composição e processos que condicionam a habitabilidade. Para a Terra, discute-se a formação e a regulação climática por oceanos e sedimentação de CO2, o surgimento de uma atmosfera rica em O2 (Grande Evento de Oxidação) e o papel de N2, O2 e O3 na manutenção da água líquida e da vida. Em Marte, analisam-se a atual atmosfera de baixa pressão dominada por CO2, a perda atmosférica e hídrica, a intensidade da radiação superficial e a química oxidante do solo que comprometem a preservação de matéria orgânica. O texto enfatiza a complementaridade entre estudos atmosféricos e investigações do subsolo, onde refúgios subsuperficiais com menor dose de radiação e oxidação química atenuada são identificados como os locais mais promissores para preservação de bioassinaturas. O artigo adota caráter didático a partir de uma abordagem integradora, apoiando a compreensão de estudantes e simpatizantes das áreas de astronomia e astrobiologia acerca dos processos-chave que regem a habitabilidade planetária.Gustavo Rodrigues; Anthony Henrique Perucci Mostaro

Perspective (graphical); Subject (documents); Context (archaeology); Interpretation (philosophy); Reflexivity; Foot (prosody); Humanities; Philosophy; Sociology

2026-04-09https://doi.org/10.47456/cad.astro.v7n1.51028Cadernos de Astronomia 20261Aplicações da inteligência artificial na identificação de reabsorção óssea em implante dentárioObjetivo: Comparar o uso de modelos de inteligência artificial (IA) para detectar, reabsorção óssea e peri‑implantite em pacientes portadores de implantes dentários por meio de exames de imagem. Métodos: Trata-se de uma revisão sistemática que seguiu o rotocolo PRISMA com busca em bases de dados indexadas (Scopus, Web of Science, PubMed/MEDLINE, SciELO, Google Acadêmico e IEEE Xplore) nos últimos 10 anos. Foi realizada a remoção de duplicatas e triagem por títulos, resumos e leitura na íntegra dos artigos encontrados. Resultados: Dezesseis estudos preencheram os critérios; a maioria utilizou redes neuronais convolucionais (CNN) para segmentação automática de implantes e mensuração da perda óssea, com acurácia entre 70 % e 97 %. Modelos de aprendizado de máquina com dados clínicos ou radiológicos tiveram desempenho variável. Consideraçôes finais: Técnicas de IA demonstram alta acurácia na detecção de reabsorção óssea peri‑implantar, embora a generalização seja limitada pelo tamanho das bases de dados, heterogeneidade metodológica e necessidade de padronização de protocolos.Larissa Costa Freitas; Lorena Aparecida Nery Araújo; Analina Braga Apolinário; Ronaldo Luis Almeida de Carvalho; Priscila Vanessa Zabala Capriles Goliatt; Fabíola Pessôa Pereira Leite

Data collection; Training set; Reading (process); Artificial neural network; Computer science; Artificial intelligence

2026-04-09https://doi.org/10.25248/reas.e23410.2026Revista Eletrônica Acervo Saúde 20261Investigating the Reactivity and Selectivity in Nucleophilic Fluorination of Secondary Alkyl Bromides and Mesylates: Assessment of the Effect of Counterion and Bulky AlcoholsSynthesis of secondary alkyl fluorides via nucleophilic substitution faces the problem of high competition with E2 processes. This competition depends on the chemical environment of the substrate, the counterion, and the hydrogen bonding to the fluoride ion. Herein, we combined reliable theoretical calculations and experimental studies to probe the reactivity and selectivity of different substrates. The calculations have shown the significance of S N 2 versus E2 competition in various chemical environments. In the experiments, we have tested the use of potassium fluoride combined with 18‐crown‐6 and the bulky alcohols pinacol and 2‐trifluoromethyl‐2‐propanol (TBOH‐F3) with several alkyl bromides and mesylates. The combination of tetrabutylammonium fluoride (TBAF) with these alcohols was also evaluated. We have found that potassium fluoride, combined with the crown ether and the bulky alcohols, is more selective than TBAF combined with these alcohols, although TBAF is more reactive. Alkyl mesylates are less prone to the formation of E2 products, and high fluorination yields can be obtained when using KF (potassium fluoride) combined with 18‐crown‐6 and pinacol in acetonitrile solvent. We have also identified 2‐bromo‐1‐phenylpropane as a very challenging substrate. Even when using a high concentration of 1,1,1,3,3,3‐hexafluoro‐2‐propanol in acetonitrile solution, fluorination of this substrate was not achieved.Eloah P. Ávila; Luís F. Resende; Mauro V. de Almeida; Josefredo R. Pliego

Reactivity (psychology); Nucleophile; Alkyl; Selectivity; Pinacol; Acetonitrile; Nucleophilic substitution; Fluoride; Ether; Chemistry; Medicinal chemistry; Organic chemistry; Alcohol; Counterion; Williamson ether synthesis; Potassium fluoride; Solvolysis; Nucleophilic aromatic substitution; Substrate (aquarium); Alkylation

2026-04-09https://doi.org/10.1002/ejoc.70385European Journal of Organic Chemistry 20261Predictive power of deep squat and Abalakov jump tests in roundhouse kick performance among elite striking athletesThis study investigated the relationship between variables of the deep squat jump (DSJ) and the Abalakov jump (ABK) and the performance of the rear leg roundhouse kick in elite combat sport athletes. Twenty-seven elite taekwondo athletes (12 females) performed three attempts of each movement: DSJ and ABK (measured with Pasco® force platforms), and the roundhouse kick (analyzed with Vicon® motion capture systems). The key findings demonstrated that specific force and power metrics from the jumps are significant predictors of kicking kinematics. For the DSJ, the rate of force development (RFD) in the first 100 ms of the concentric phase (RFDcon) was a primary predictor, independently explaining 21% of the variance in linear foot velocity (p=0.009) and 30.3% in linear foot acceleration (p=0.003). Furthermore, for the non-dominant (stance) limb, takeoff peak force independently predicted angular hip acceleration (R²=0.144, p=0.029). For the ABK, the eccentric braking RFD at 100 ms (RFDecc) emerged as a strong predictor, accounting for 24% of the variance in angular hip acceleration (p=0.006). In conclusion, this study validates the DSJ and ABK as practical tools for assessing qualities critical to roundhouse kick performance. Coaches should prioritize monitoring RFDcon and stance limb strength during a DSJ, as well as the RFDecc during an ABK, to evaluate and train for improved kicking power.Cinthya Luiza Rezende Oliveira; Ciro José Brito; Ignacio Andrés Roa Gamboa; N. Almeida; Mateus Rossow Souza; Dany Alexis Sobarzo Soto; LUCIO MARQUES VIEIRA-SOUZA; Bianca Miarka; Esteban Aedo-Muñoz

Jump; Squat; Concentric; Acceleration; Eccentric; Athletes; Countermovement; Elite; Elite athletes; Physical medicine and rehabilitation; Power (physics); Mathematics; Ground reaction force; Force platform; Plyometrics; Engineering; Jumping

2026-04-08https://doi.org/10.18002/rama.v21i1.2607Revista de artes marciales asiáticas 20261Supplementary Tables for "Explainable AI (XAI) in decision support for mitigating carbon emissions in agriculture: A Systematic Review"This document provides the supplementary material for the paper titled "Explainable AI (XAI) in decision support for mitigating carbon emissions in agriculture: A Systematic Review," containing all the necessary tables for the full understanding of the systematic review method and results. This material includes the detailed inclusion and exclusion criteria, the complete list of titles and identifiers of the selected primary studies, as well as all result analysis tables, covering the frequencies of each identified category and their respective detailed descriptions. Due to the space limitations of the short paper format, this extended document is provided to ensure methodological transparency and to offer a granular view of the synthesized data.Pedro José C. de Almeida; Davi Moljo Domingues; Regina Braga; José David; Barbara Melo Quintela

Decision support system; Transparency (behavior); Inclusion (mineral); Greenhouse gas; Carbon fibers; Identifier; Operations research; Computer science; Space (punctuation); Engineering; Data mining; Decision analysis; Environmental science

2026-04-10https://doi.org/10.5281/zenodo.19497753Zenodo (CERN European Organization for Nuclear Research) 20261Standardizing ischemic preconditioning research in applied exercise physiologyResearch on ischemic preconditioning (IPC) within applied exercise physiology has expanded considerably over the past few decades. While IPC demonstrates potential for enhancing exercise performance and accelerating muscle recovery, its widespread adoption is currently hindered by substantial heterogeneity in protocols and applications. Notably, recent evidence suggests that the reported ergogenic effects of IPC become less apparent in studies utilizing a three-arm experimental design (i.e., IPC, placebo and control). This variability compromises reproducibility and complicates the establishment of IPC as a reliable physiological stimulus and an ergogenic aid. Consequently, this narrative review aims to advance the field by identifying gaps, proposing methodological standards and encouraging the standardization of protocol design. We evaluate critical parameters, including cuff width, inflation pressure, number of cycles, and the duration of occlusion and reperfusion, while addressing the implications of experimental design and the confounding influence of placebo effects. As significant questions remain regarding the optimization of IPC for physical work capacity and muscle recovery, a standardized framework is urgently required to guide future research and evidence-based practice in human performance physiology.Moacir Marocolo; Rodrigo Hohl; Michał Wilk; Gustavo Ribeiro Da Mota; Hiago L. R. Souza

Human physiology; Placebo; Exercise physiology; Protocol (science); Sports medicine; Ischemic preconditioning; Physical exercise; Stimulus (psychology); Medicine; Confounding; Endurance training; Physical therapy; Narrative review; Physical activity; Physical medicine and rehabilitation; Intensive care medicine; Standardization

2026-04-10https://doi.org/10.1007/s00421-026-06226-5European Journal of Applied Physiology 20261Advancements in diverse chemical scaffolds for antimalarial drug discovery: a ten-year hit-to-lead retrospectiveMalaria remains one of the most devastating parasitic diseases worldwide, accounting for hundreds of millions of cases and significant mortality annually. Despite the availability of therapeutic interventions, the efficacy of current pharmacological treatments is increasingly compromised by the emergence and spread of multidrug-resistant Plasmodium strains, underscoring an urgent need for novel antimalarial agents. In this context, the transition from hit identification to lead optimization (hit-to‑lead) represents a pivotal stage in the drug discovery pipeline, ensuring that promising chemical scaffolds are refined for enhanced potency and safety. This review provides a comprehensive retrospective of hit-to‑lead advancements over the past decade, scrutinizing the pharmacological and structural evolution of diverse chemical classes. We detail the structure-activity relationships, in vitro potencies, pharmacokinetic properties, and in vivo efficacy and safety profiles of identified candidates, while addressing their inherent benefits and limitations. Our analysis covers 32 distinct chemical classes, of which 16 have suggested biological targets and 16 remain with unidentified mechanisms of action. Notably, 33 compounds emerged with demonstrated vivo activity, highlighting the significant progress made in delivering robust lead candidates. By consolidating these findings, this review underscores the critical importance of systematic hit-to‑lead optimization in the global effort to develop the next generation of antimalarial therapies.Marcelo Augusto Pereira Januário; Douglas Davison da Silva Oliveira; Flávio Luis Cardoso Silveira; Júlia Oliveira Carvalho; Rafaela Marçal Sousa; Celso de Oliveira Rezende Júnior

Drug discovery; Drug; Malaria; In vivo; Drug development; Lead (geology); Pharmacology; Computational biology; Chemistry; Intensive care medicine; Identification (biology); Medicine; Risk analysis (engineering); Plasmodium falciparum

2026-04-10https://doi.org/10.1016/j.bmc.2026.118658Bioorganic & Medicinal Chemistry 20261A new species of Aplectana Railliet & Henry (Nematoda: Cosmocercidae) in Amphisbaena alba Linnaeus (Squamata: Amphisbaenidae) from Minas Gerais State, BrazilFabiano Matos Vieira; Paula Araujo Gonçalves; Sueli de Souza Lima; Bernadete Maria de Sousa; Luís Cláudio Muniz-Pereira

Taxonomy (biology); Ophidia; Paratype; Holotype; Biology; Zoology; Geography

2026-04-10https://doi.org/10.48580/df9c.v85The Catalogue of Life 20261OSTEONECROSE MANDIBULAR RELACIONADA AO USO DE BIFOSFONATOS E SEUS IMPACTOS NA REABILITAÇÃO COM IMPLANTES DENTÁRIOSA osteonecrose mandibular associada ao uso de bifosfonatos é uma condição clínica de etiologia multifatorial, decorrente do uso de medicamentos antirreabsortivos, caracterizada pela falha no reparo ósseo e frequentemente relacionada a intervenções odontológicas invasivas, como a instalação de implantes dentários. O objetivo do presente estudo foi investigar, por meio de revisão da literatura, a relação entre o uso de bifosfonatos e o risco de desenvolvimento de osteonecrose mandibular, com ênfase no sucesso de implantes, fatores de risco associados e implicações clínicas. Foram selecionados artigos publicados entre 2021 e 2026 na base de dados PubMed, utilizando os descritores “Bisphosphonate Associated Osteonecrosis of the Jaw”, “Osteonecrosis”, “Bisphosphonate” e “Dental Implants”. A partir da análise dos estudos, observou-se que, embora pacientes em uso de bifosfonatos não apresentem aumento significativo na falha de implantes em alguns contextos, há associação relevante entre o uso desses fármacos e o desenvolvimento de osteonecrose, especialmente após procedimentos cirúrgicos. Fatores como via de administração, tempo de uso, dose do medicamento, idade avançada, presença de peri-implantite e características do implante influenciam diretamente esse risco. Ademais, a suspensão do fármaco por períodos prolongados demonstrou potencial efeito protetor. Apesar de evidências que indicam a possibilidade de instalação segura de implantes em determinados casos, persistem divergências na literatura quanto à previsibilidade desses procedimentos. Diante disso, ressalta-se a importância de uma abordagem clínica criteriosa, individualizada e baseada em evidências, visando minimizar riscos e otimizar os desfechos terapêuticos.Helena Mendes Amorim; Gabriela Marques de Mello Costa; Luigi de Almeida Abertoni; Eduardo Stehling Urbano

Periodontal disease; Dental implant; Implant; Osseointegration; Medicine; Gynecology; Dentistry

2026-04-10https://doi.org/10.56238/sevened2026.016-006Seven Editora eBooks 20261A Comprehensive Methodology for Battery Energy Storage System Representation with Frequency Regulation in Power Flow StudiesMaurício Cabette Lanini; João Alberto Passos Filho

Frequency regulation; Representation (politics); Energy (signal processing); Power flow; Power (physics); Energy storage; Battery (electricity); Automatic frequency control; Electric power system; Computer science; Embedding; Frequency response; Energy flow; Control engineering; Engineering; Electronic engineering; Flow (mathematics); Control theory (sociology); Frequency domain

2026-04-10https://doi.org/10.21203/rs.3.rs-9272401/v1Research Square 20261Supplementary Tables for "Explainable AI (XAI) in decision support for mitigating carbon emissions in agriculture: A Systematic Review"This document provides the supplementary material for the paper titled "Explainable AI (XAI) in decision support for mitigating carbon emissions in agriculture: A Systematic Review," containing all the necessary tables for the full understanding of the systematic review method and results. This material includes the detailed inclusion and exclusion criteria, the complete list of titles and identifiers of the selected primary studies, as well as all result analysis tables, covering the frequencies of each identified category and their respective detailed descriptions. Due to the space limitations of the short paper format, this extended document is provided to ensure methodological transparency and to offer a granular view of the synthesized data.Pedro José C. de Almeida; Davi Moljo Domingues; Regina Braga; José David; Barbara Melo Quintela

2026-04-10https://doi.org/10.5281/zenodo.19497754Zenodo (CERN European Organization for Nuclear Research) 20261TECHNICAL FEASIBILITY OF USING STEEL SLAG AS RAILWAY BALLAST: FINE PARTICLE GENERATION AND ELECTRICAL RESISTIVITYLaura Soranço; Katrine Setfânia Couto; Geraldo Luciano Marques; Júlia Castro Mendes

Slag (welding); Ballast; Abrasion (mechanical); Electrical resistivity and conductivity; Clogging; Porosity; Residual; Materials science; Metallurgy; Particle (ecology); Composite material

2026-01-01https://doi.org/10.2139/ssrn.6560251SSRN Electronic Journal 20261Genomic Variants Associated With Oocyte and Embryo Production in Dairy Gir CattleRenata de Fátima Bretanha Rocha; Haniel Cedraz de Oliveira; Marta Fonseca Martins; Marco Antônio Machado; João Claudio do Carmo Panetto; Marcos Vinicius Barbosa da Silva; Simone Eliza Facioni Guimarães

Oocyte; Embryo; Embryogenesis; Animal production; Milk production; Biology; Genetics; Andrology

2026-04-12https://pmc.ncbi.nlm.nih.gov/articles/PMC13070668/PubMed Central 20261A Prototype of a Patch Antenna Array for Ground-to-Ground Wireless Power TransferThis paper focuses on the design and experimental validation of a$2 \times 2$patch antenna array for ground-to-ground wireless power transfer at 2.4 GHz. The antenna, implemented on a Rogers RO4725JXR substrate, was optimized in CST Microwave Studio Suite for impedance matching, gain, and radiation efficiency. Measurements show a minimum reflection coefficient of$-38.32 \mathbf{~ d B}$at$2.425 \mathbf{~ G H z}$and a$-10 \mathbf{~ d B}$bandwidth of 33 MHz, validating the agreement with simulations.Luís Guilherme da Silva Costa; Cláudia de Magalhães Santos Fonseca; Chrysléne Marilande Merveilles Adetonah; Benigno Rodríguez Díaz; Moisés V. Ribeiro

Patch antenna; Microstrip antenna; Wireless power transfer; Antenna (radio); Power (physics); Wireless; Antenna array; Computer science; Electrical engineering; Electronic engineering; Engineering; Acoustics; Physics; Antenna rotator

2026-02-22https://doi.org/10.1109/lacap67012.2026.11471212 20261Systematics of Marmosa Subgenus Micoureus With Emphasis in ‘ rapposa ’ Group (Didelphidae, Marmosini): Geographic Variation and Revalidation of M. budiniABSTRACT Micoureus is the most species‐rich subgenus within the genus Marmosa . Conflicting arrangements regarding the number of species comprising this subgenus have been proposed and the validity of M . budini has been debated. Here, we used an approach integrating genetic and morphological data were conducted to reanalyze the ‘ rapposa ’ group, investigate its biogeographic context, and test the status of M . budini as a distinct species of the M . rapposa complex. One mitochondrial and one nuclear marker were sequenced to recover species trees; divergence data and population aspects were inferred from mitochondrial data. Museum specimens were examined, including holotypes. The biogeographic data suggest the diversification in the ‘ rapposa ’ group to be associated with tectonism in the Andes and the Pebas System. Genetic analysis and external and craniodental morphology differences corroborate the species status of M . budini , with new record for Rondônia, Brazil, and M . rapposa would remain restricted to Peru. Marmosa rutteri exhibits intrapopulation variations driven by habitat fragmentation in the Pleistocene cycles and fluvial formations of the Amazon, and the separation in relation to M . budini coincides with climatic oscillations of the Late Quaternary and the Ucayali River.Maria Clara Santos Ribeiro; Aldo Caccavo; Joyce Rodrigues do Prado; Cibele Rodrigues Bonvicino

Subgenus; Systematics; Pleistocene; Biogeography; Vicariance; Population; Phylogeography; Population genetics; Reproductive isolation; Genus; Biology; Zoology; Ecology; Evolutionary biology; Genetic divergence; Habitat; Genetic structure; Taxonomy (biology); Quaternary; Fragmentation (computing); Biological dispersal; Species complex

2026-04-13https://doi.org/10.1111/zsc.70057Zoologica Scripta 20261Design of Rectangular Patch Antenna and Low-Pass Filter for Energy Harvesting at 2.45 GhzThis work addresses the design of an integrated rectangular patch antenna with a stepped-impedance low-pass filter for RF energy harvesting at 2.45 GHz, implemented on an FR-4 substrate and simulated in CST Microwave Studio. After optimization, the integrated structure still operates at$2.45 \text{GHz}\left(\left\vert \mathrm{S}_{11}\right\vert<-10 \text{dB}\right)$with a realized gain of 3 dBi. The results indicate that integrating the stepped-impedance LPF into the feedline maintains radiating performance while providing a compact RF front-end with out-of-band attenuation for energyharvesting receivers.Chryslène M. M. Adetonah; Cláudia M. S. Fonseca; L. R. R. Costa; Benigno R. Díaz; Moisés V. Ribeiro

Patch antenna; Energy harvesting; Filter (signal processing); Energy (signal processing); Antenna (radio); Acoustics; Physics; Microstrip antenna; Engineering; Electronic engineering; Electrical engineering; Materials science; Computer science; Optics

2026-02-22https://doi.org/10.1109/lacap67012.2026.11471149 20261Structural studies on NaPO 3 –MoO 3 –V 2 O 5 glasses and glass-ceramicsGlass samples in the ternary NaPO 3 –MoO 3 –V 2 O 5 system were prepared using the melt-quenching technique and structurally characterised by XRD, DSC, Raman and infrared spectroscopy. The system exhibited a wide glass-forming composition range, with observed T g trends attributed to the formation of transition metal cluster structures and modifications in the phosphate network, leading to less connected Q 1 and Q 0 phosphate units within the glass matrix. Selected 70% transition metal-containing compositions were used to prepare their corresponding glass-ceramics. XRD analysis revealed the preferential crystallisation of vanadium-containing phases interconnected with phosphate tetrahedra, effectively replicating the local structural environment of their parent glass.Patrick Carvalho; Tamires Martinhão Machado; Adriana M. Silva; Luiz F. Cappa de Oliveira; Mauricio A.P. Silva

Raman spectroscopy; Crystallization; Phosphate; Phosphate glass; Ternary operation; Glass transition; Ternary numeral system; Infrared spectroscopy; Materials science; Crystallography; Cluster (spacecraft); Mineralogy; Transition metal; Infrared; Nuclear chemistry; Zinc phosphate; Chemistry; Chemical engineering

2026-03-27https://doi.org/10.13036/17533562.67.1.07Physics and Chemistry of Glasses European Journal of Glass Science and Technology Part B 20261Multiscale stochastic modeling for calcium dynamics in cardiac electrophysiology: assessing whole-cell model reliability under phosphorylation and LCC downregulationIntracellular calcium (Ca 2+ ) dynamics drives contractile function in cardiac myocytes. In particular, L-type Calcium Channels (LCCs) and Ryanodine Receptors (RyRs) are organized in microdomains, where LCCs trigger substantial Ca 2+ release from the Sarcoplasmic Reticulum (SR) via RyRs. Different microdomains can be coupled at different length scales by calcium diffusion or common external activation. We present a Scalable Aggregate Calcium Release Unit (SA-CaRU) model for human ventricular myocytes that integrates a recently developed Markov Chain (MC)-based description of LCCs, replacing classical Hodgkin–Huxley gates. Our approach is based on previously published MC-based frameworks for the human heart, enabling stochastic gating and reproducing evoked local Ca 2+ release statistics across different effective levels of microdomain aggregation. Our single-SA-CaRU system captures, within a unified framework, key features of microscale and macroscale Ca 2+ cycling and allows, for the first time, systematic exploration of variability in SR Ca 2+ release as a function of effective microdomain size and coupling. Simulations with increasing numbers of channels reveal that the transition from stochastic to deterministic-like Ca 2+ behavior is typically sharp at a specific cluster size. Under normal (healthy) conditions, this occurs at <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="m1"> <mml:mrow> <mml:mi mathvariant="script">O</mml:mi> <mml:mrow> <mml:mo stretchy="false">(</mml:mo> <mml:mrow> <mml:mn>1</mml:mn> <mml:msup> <mml:mrow> <mml:mn>0</mml:mn> </mml:mrow> <mml:mrow> <mml:mn>2</mml:mn> </mml:mrow> </mml:msup> </mml:mrow> <mml:mo stretchy="false">)</mml:mo> </mml:mrow> </mml:mrow> </mml:math> LCCs (with mild sensitivity to the RyR:LCC scaling). However, under high phosphorylation or LCC upregulation, stochasticity persists and convergence to deterministic-like behavior is absent or markedly delayed even for total LCC numbers as large as 20,000. In these conditions, whole-cell deterministic models become doubtful, since their behavior can be qualitatively different from that arising from any plausibly mediated coordination of subcellular calcium release units.Gustavo Montes Novaes; Rodrigo Weber dos Santos; Sergio Alonso; Enrique Álvarez-Lacalle

Lipid microdomain; Ryanodine receptor; Calcium; Gating; Multiscale modeling; Stochastic modelling; Calcium signaling; Phosphorylation; Chemistry; Biophysics; Biological system; Function (biology); Voltage-dependent calcium channel; Markov chain; Dynamics (music); Microscale chemistry; Endoplasmic reticulum; Calcium in biology

2026-04-13https://doi.org/10.3389/fnetp.2026.1727426Frontiers in Network Physiology 20261Unlocking the cognitive puzzle of autism and your implication for education: the intersection of predictive processing, theory of mind, executive functions, and central coherenceAutism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by marked heterogeneity in cognitive profiles, social interaction, and adaptive functioning. This narrative review synthesizes four major cognitive models (Theory of Mind, Executive Functions, Central Coherence, and Predictive Processing) and examines how they contribute, individually and in combination, to understanding ASD and its educational implications. Drawing on recent neuroimaging, longitudinal, and educational studies, we discuss how difficulties in these partially dissociable yet interacting domains may affect academic performance and social development, shaping distinct developmental trajectories within the spectrum. Based on this framework, we analyze the concept of transferability as a key metric to evaluate intervention outcomes, arguing that approaches targeting cognitive mechanisms can yield broader functional gains than exclusively behavioral interventions. Finally, we review evidence-based practices recommended by the National Clearinghouse on Autism Evidence and Practice, considering their applicability across school stages, and clarify the distinctions between methods, programs, models, and protocols, emphasizing the central role of family involvement in planning and implementing individualized educational supports.Júlio César Claudino dos Santos; Janaína Aparecida Favero Desio; Túlia Fernanda Meira Garcia; Everton Ferreira de Souza; Silvana Henkes; Júlia Cunha de Borba; Estefania Miranda Borges; Maiara de Aguiar da Costa; Luana Stangherlin dos Santos; Cinara Ludvig Gonçalves

Autism; Cognition; Intersection (aeronautics); Coherence (philosophical gambling strategy); Theory of mind; Social cognition; Cognitive systems; Psychology; Cognitive psychology; Developmental psychology; Joint attention; Executive functions

2026-04-13https://doi.org/10.1080/20473869.2026.2651407International Journal of Developmental Disabilities 20261“Autonomy & Management in Prison Nursing”. Development and validation of a mobile applicationObjective: To describe the process of development and validation of the content and semantics of the "Autonomy & Management in Prison Nursing" application for nurses working in prison units in Minas Gerais, Brazil. Methods: This methodological study employed the Contextualized Instructional Design method, following its four recommended stages: analysis, design and development, implementation, and evaluation. In the first phase, 164 nursing professionals participated by completing a semi-structured questionnaire addressing working conditions and professional autonomy. In the second phase, the application was developed with the support of an information technology professional. The third phase consisted of configuring and making the application available. Finally, in the fourth phase, content validation was carried out by 23 specialized judges and semantic validation by 51 nurses. Results: The content validation of the application was satisfactory, as all indicators - total agreement rate, Content Validity Index (0.962; p<0.01), and overall Cronbach's Alpha coefficient (0.969) - reached satisfactory levels. Semantic validation was also satisfactory, as all Cronbach's Alpha coefficients achieved high values, indicating correlation among the items and excellent reliability of the application. Conclusion: The "Autonomy & Management in Prison Nursing" application was developed and demonstrated satisfactory evaluation regarding both content and semantics, showing good adaptation to the proposed criteria and high internal consistency among the items.Leslie Diniz Alves; Leonardo Vieira Guimarães; Luiz Almeida da Silva; Maria Lucia do Carmo Cruz Robazzi; Namiê Okino Sawada; Fábio de Souza Terra; SERGIO VALVERDE MARQUES DOS SANTOS

Prison; Content validity; Reliability (semiconductor); Internal consistency; Consistency (knowledge bases); Content analysis; Adaptation (eye); Process (computing); Computer science; Psychology; Process management; Index (typography); Knowledge management; Content (measure theory); Nursing management

2026-01-01https://doi.org/10.17533/udea.iee.v44n1e09Investigación y Educación en Enfermería 20261Adhesive impact on bond strength of treated ceramics: systematic reviewR de Souza; LC Freitas; L Araújo; C Lima; T Pires; T Costa; R Barra; F Leite; S Butler

Adhesive; Bond strength; Bonding strength; Adhesive bonding; Self adhesive; Materials science; Composite material

2026-01-01https://doi.org/10.1016/j.dental.2026.03.050Dental Materials 20261Instruments for Assessing Spirituality in Patients with Chronic or Advanced Illnesses: A Systematic Review of the Last 15 YearsBackground/Objectives: Spirituality is a key component of coping and well-being in chronic and advanced illness, yet its assessment remains inconsistent across clinical settings. To identify, classify, and critically analyze the most commonly used and validated instruments for measuring spirituality in clinical contexts, focusing on their ability to assess the current spiritual state from a multidimensional perspective (cognitive, behavioral, and affective expressions). Methods: A systematic literature review was conducted using PubMed, Scopus, and Web of Science (2011–2024). Inclusion criteria targeted validation studies of instruments assessing spirituality in adults with chronic or advanced illnesses or in palliative care. A dual conceptual–functional classification was applied, and a custom scoring system was developed to evaluate psychometric quality. Contamination and tautological aspects were also examined. Results: Forty-three instruments were identified across 42 studies. Of these, 93.02% included cognitive, affective, and behavioral dimensions. Most were validated in oncology or chronic disease populations. Content validity and internal consistency were the most reported psychometric properties; responsiveness was rarely evaluated. Conclusions: The available instruments reflect several conceptual and functional approaches. The classification proposed in this review provides practical guidance for selecting scales according to specific clinical goals and settings, supporting the evaluation of the current spiritual state and the integration of spirituality into healthcare practice. Further research is recommended to develop culturally sensitive and responsive instruments suitable for diverse clinical contexts.María Ángeles Portillo-Gil; Giancarlo Lucchetti; Rocío de Diego‐Cordero

Spirituality; Coping (psychology); MEDLINE; Content validity; Internal consistency; Inclusion (mineral); Psychometrics; Perspective (graphical); Systematic review; Medicine; Psychology; Clinical psychology; Health care; Conceptual framework; Clinical Practice; Psychotherapist; Mental health; Health professionals

2026-04-12https://doi.org/10.3390/healthcare14081013Healthcare 20261Predicting Pt-195 NMR Chemical Shift in Pt(II)-Sn(II) ComplexesPlatinum chemistry covers a wide range of applications, including homogeneous and heterogeneous catalysis as well as cancer therapy. Numerous Pt complexes have been synthesized and studied in recent years, with NMR spectroscopy serving as the primary technique for structural characterization. The 195Pt nucleus has favorable features for NMR studies, being highly sensitive to ligand type and structural environment. From a computational perspective, factors such as solvent effects, relativistic corrections, and the electronic structure of the ligands strongly influence the calculated NMR parameters. Consequently, establishing a general computational protocol for 195Pt NMR prediction remains a challenging task. In this work, we present a systematic validation and extension of our previously developed computational protocol, originally proposed for Pt(II) complexes, in studying 195Pt NMR chemical shifts in Pt(II)-Sn(II) complexes. A benchmark set of 100 Pt(II)-Sn(II) complexes was analyzed, yielding good agreement with experimental data (R2 = 0.86, MRD = 3.6%, MAD = 163 ppm), which is remarkable given the structural diversity and broad range of chemical shifts covered.M. Graça Pereira; Larissa P. N. M. Pinto; Hélio F. Dos Santos; Diego Paschoal

Nuclear magnetic resonance spectroscopy; Chemical shift; Homogeneous; Ligand (biochemistry); Molecule; Solvent; Spectroscopy; Two-dimensional nuclear magnetic resonance spectroscopy; Range (aeronautics); Chemistry; Computational chemistry; Chemical physics; Nuclear magnetic resonance crystallography; Transverse relaxation-optimized spectroscopy; Carbon-13 NMR satellite; Electronic structure; NMR spectra database; Carbon-13 NMR; Solid-state nuclear magnetic resonance; Basis set

2026-04-13https://doi.org/10.3390/magnetochemistry12040049Magnetochemistry 20261VIVÊNCIA DE UMA ACADÊMICA DE MEDICINA EM UM SERVIÇO DE NEUROCIRURGIA NO ESPÍRITO SANTO: RELATO DE EXPERIÊNCIAA graduação em Medicina contempla diversas áreas do conhecimento médico, porém nem sempre proporciona aprofundamento prático em todas as especialidades, como frequentemente ocorre na neurocirurgia, área caracterizada por elevada complexidade técnica e assistencial. Nesse contexto, os estágios optativos configuram-se como estratégias formativas relevantes, permitindo ao discente explorar especialidades específicas e vivenciar a prática clínica de forma mais aprofundada. O objetivo deste estudo foi relatar a experiência de uma acadêmica de Medicina durante estágio optativo em um serviço de neurocirurgia de um hospital público no estado do Espírito Santo, destacando os aspectos assistenciais, acadêmicos e formativos vivenciados, com ênfase tanto no desenvolvimento profissional quanto interpessoal. Trata-se de um estudo descritivo, qualitativo, do tipo relato de experiência, referente à vivência de uma estudante em um estágio optativo com carga horária total de 260 horas, realizado entre maio e junho de 2025. O estágio ocorreu em um serviço estruturado, com equipe multiprofissional e rotina cirúrgica intensa, apresentando média de três procedimentos neurocirúrgicos diários, incluindo desde técnicas minimamente invasivas até cirurgias de alta complexidade com uso de neuronavegação e neuromonitorização. Ao longo do período, foram acompanhados 81 procedimentos, possibilitando observação direta e análise reflexiva das práticas clínicas, organizacionais e humanas envolvidas no cuidado neurocirúrgico. A experiência evidenciou não apenas o aprimoramento técnico e o amadurecimento clínico, mas também lacunas da formação médica tradicional no que se refere à prática e à humanização em especialidades de alta complexidade. Conclui-se que os estágios optativos desempenham papel fundamental na formação médica, ao favorecer a integração entre conhecimento técnico, escuta qualificada e cuidado centrado no paciente, constituindo ferramentas estratégicas para uma formação mais crítica, ética, humana e resolutiva.Maria Fernanda Fadel Lacreta; Maria Eduarda Braga Marin; Paula Carolina Pilon Gaiotto; Lívia Martins Gazoni Tardin; Antônio Rony da Silva Pereira Rodrigues

Ethics committee; Context (archaeology); Philosophy; Humanities; Medicine

2026-04-13https://doi.org/10.70779/aijshs.v5i4.496Asclepius International Journal of Scientific Health Science 20261The Impact of Substrate Parameter Accuracy on the Patch Antenna PerformanceThis paper discusses the impact of discrepancies between datasheet specifications and measurement parameters of the substrate used to fabricate patch antennas, including dielectric constant, loss tangent, and substrate thickness. The design of several prototypes shows that incorporating measured substrate parameters into the design process yields the best agreement between the design and the prototype.Cláudia de M. S. Fonseca; L. R. R. Costa; Chryslène M. M. Adetonah; Belén Díaz; Moisés Ribeiro; Marco Aurélio O. Schroeder; Glaucio L. Ramos

Patch antenna; Substrate (aquarium); Microstrip antenna; Antenna (radio); Reflection (computer programming); Materials science; Acoustics; Optics; Optoelectronics; Electronic engineering

2026-02-22https://doi.org/10.1109/lacap67012.2026.11471219 20261ANÁLISE DESCRITIVA DA DENGUE NO BRASIL: EPIDEMIOLOGIA, IMPACTO ECONÔMICO E IMPLICAÇÕES PARA O SISTEMA DE SAÚDEA dengue permanece como um importante problema de saúde pública no Brasil, com repercussões relevantes sobre a morbimortalidade e os custos do sistema de saúde. Nesse contexto, o presente estudo teve como objetivo avaliar o perfil epidemiológico da dengue e seus impactos econômicos e assistenciais no país. Trata-se de um estudo epidemiológico observacional, descritivo e quantitativo, de delineamento longitudinal retrospectivo, baseado na análise de dados secundários referentes ao período de janeiro de 2019 a dezembro de 2023, obtidos a partir do Sistema de Informações Hospitalares do Sistema Único de Saúde (SIH/SUS), disponibilizado pelo DATASUS. Foram analisadas variáveis relacionadas ao número de internações hospitalares, óbitos, taxas de mortalidade e custos hospitalares associados à dengue, permitindo a avaliação do impacto da doença sobre o sistema público de saúde. Os resultados demonstraram redução dos custos hospitalares em 2020, seguida por aumentos expressivos nos anos subsequentes, acompanhando o recrudescimento dos casos e da gravidade clínica da doença. As regiões Sudeste, Nordeste e Centro-Oeste concentraram os maiores custos e as maiores taxas de mortalidade em anos distintos, evidenciando desigualdades regionais na carga da doença. Observou-se maior prevalência de internações entre mulheres, adultos jovens e indivíduos autodeclarados pardos, além de variações temporais possivelmente relacionadas à circulação de diferentes sorotipos virais. Esses achados corroboram a literatura, que aponta influência de fatores ambientais, climáticos e falhas no controle vetorial no aumento da incidência e dos custos da dengue. Conclui-se que houve crescimento progressivo dos casos, da mortalidade e dos gastos hospitalares com dengue no período analisado, reforçando a necessidade de investimentos contínuos em ações preventivas, vigilância epidemiológica e controle do vetor. Destacam-se como limitações a possibilidade de subnotificação e a ausência de dados sobre custos indiretos, o que pode subestimar a magnitude real do impacto econômico da doença.Maria Fernanda Fadel Lacreta; Antonia Fontes Marietti; Letícia de Jesus Testa; Paula Ester de Oliveira Almeida; Letícia Garotti da Cunha Bueno; Guilherme de Andrade Ruela

Dengue fever; Medical costs; Cost analysis; Mortality rate; Medicine

2026-04-13https://doi.org/10.70779/aijshs.v5i4.498Asclepius International Journal of Scientific Health Science 20261Effect of a Liquid Rectangular Prism Dielectric Resonator on the Patch Antenna PerformanceChryslène M. M. Adetonah; Cláudia M. S. Fonseca; L. R. R. Costa; Benigno R. Díaz; Moisés V. Ribeiro

Prism; Patch antenna; Dielectric; Microstrip antenna; Antenna (radio); Resonator; Materials science; Optics; Acoustics; Dielectric resonator antenna; Broadband

2026-02-22https://doi.org/10.1109/lacap67012.2026.11471200 20261CRESCIMENTO E DESENVOLVIMENTO ECONÔMICO NOS ARRANJOS POPULACIONAIS DE JUIZ DE FORA (MG) E TRÊS RIOS (RJ)Este artigo tem por objetivo analisar se houve convergência de crescimento e de desenvolvimento econômico, entre os arranjos populacionais de Juiz de Fora (MG) e Três Rios (RJ), entre 2013 e 2023. Alcança-lo pressupõe (I) apresentar uma breve discussão teórica sobre crescimento econômico, desenvolvimento econômico e teoria da convergência; (II) caracterizar os arranjos populacionais selecionados para análise; e, (III) aplicar o modelo estatístico da teoria de convergência aos indicadores sociais (IFDM) e à renda per capita dos arranjos populacionais, de modo a identificar se houve convergência ou divergência. Constatou-se que, no período analisado, houve convergência da renda per capita e dos indicadores de desenvolvimento socioeconômico entre os Arranjos Populacionais. Entretanto, não foi constatado desempenho superior por parte dos municípios fluminenses que se beneficiaram de políticas de incentivos fiscais visando à dinamização, crescimento e desenvolvimento econômicos.Vicente dos Santos Guilherme Júnior

Per capita; Local Development; Per capita income; Paid work; Sociology; Welfare economics; Political science

2026-04-06https://doi.org/10.30681/rbegdr.v8i3.14706Revista Brasileira de Estudos de Gestão e Desenvolvimento Regional 20261Correction: In the Same Spirit. Looking for Political Legitimacy: Conservative Christian Alliances in Contemporary PeruPaulo Barrera Rivera; Véronique Lecaros

Politics; Government (linguistics); Latin Americans; Work (physics); Political science; Political economy; Economy

2026-04-14https://doi.org/10.1007/s41603-026-00336-wInternational Journal of Latin American Religions 20261ALKIMIM, Ana. O imprevisto. São Paulo: Gênio Editorial, 2023Paula Mendonça Dias

Work (physics); Identification (biology); Process (computing)

2026-01-01https://doi.org/10.1590/2316-40187528Estudos de Literatura Brasileira Contemporânea 20261Analytical modeling of foam-assisted displacement with surfactant adsorption in porous mediaWe develop an analytical framework for modeling foam-assisted displacement in porous media with surfactant adsorption, formulated as a sequence of interacting Riemann problems for a system of non-strictly hyperbolic conservation laws. The framework accommodates sequential surfactant-gas injection and supports both linear and concave adsorption models, including the Langmuir, Freundlich, and Redlich-Peterson isotherms, while remaining compatible with empirical foam formulations, such as CMG-STARS. The application of the model reveals that the surfactant front reaches a finite asymptotic position, determined solely by the adsorption intensity and injected slug parameters. In contrast, injection velocity and non-Newtonian foam rheology primarily affect transient dynamics. Higher velocities and stronger non-Newtonian behavior accelerate the interaction between gas and surfactant fronts, slowing the approach of the surfactant front to its limiting position and altering the evolution of the pressure gradient. These findings offer insight into the factors controlling surfactant propagation and may aid in developing strategies for more efficient foam-assisted displacement in porous media.Giulia C. Fritis; P. Bedrikovetski; Grigori Chapiro

Porous medium; Pulmonary surfactant; Displacement (psychology); Adsorption; Porosity; Materials science; Composite material; Chemical engineering

2026-04-15https://doi.org/10.1016/j.apm.2026.116982Applied Mathematical Modelling 20261Melanoma cutâneo inicial: critérios clínicos e dermatoscópicos para diagnóstico precoceO melanoma cutâneo constitui a forma mais agressiva de câncer de pele, sendo responsável pela maior parte das mortes relacionadas às neoplasias cutâneas, apesar de sua menor incidência. O diagnóstico precoce representa o principal fator determinante para melhores desfechos clínicos, especialmente em lesões identificadas em estágios iniciais. O presente estudo teve como objetivo analisar os principais critérios clínicos e dermatoscópicos utilizados no diagnóstico precoce do melanoma cutâneo, destacando suas aplicabilidades e limitações. Trata-se de uma revisão narrativa da literatura, de natureza qualitativa, realizada por meio de busca estruturada nas bases de dados PubMed, SciELO e ScienceDirect, incluindo estudos publicados nos últimos 10 anos. Foram selecionados 19 artigos que atenderam aos critérios de inclusão previamente estabelecidos, os quais foram analisados de forma crítica e organizados em categorias temáticas. Os resultados evidenciam que os critérios clínicos, como a regra do ABCDE e o conceito do “patinho feio”, desempenham papel relevante na triagem inicial, porém apresentam sensibilidade limitada na detecção de melanomas iniciais ou atípicos. A dermatoscopia mostrou-se superior à avaliação clínica isolada, aumentando a acurácia diagnóstica, embora sua eficácia esteja relacionada à experiência do examinador e apresente limitações em lesões com baixa expressão de critérios estruturais. Os algoritmos dermatoscópicos contribuem para a padronização da avaliação, mas não são plenamente eficazes em todos os contextos clínicos. Além disso, melanomas finos e os denominados featureless melanoma representam desafios significativos, frequentemente associados a falso-negativos. Métodos complementares, como dermatoscopia digital, microscopia confocal e inteligência artificial, demonstram potencial promissor, embora ainda apresentem limitações quanto à padronização e aplicabilidade clínica. Conclui-se que o diagnóstico precoce do melanoma cutâneo requer uma abordagem integrada, envolvendo critérios clínicos, dermatoscopia e métodos complementares, a fim de aumentar a sensibilidade e a especificidade diagnóstica e contribuir para a redução da morbidade e mortalidade associadas à doença.Ludmila Jacomo Loyola Simões; L. P. Resende; Júlia Cristina Caverçan Gomes; Renata Trindade Gonçalves; Felipe Veiga Kezam Gabriel

Melanoma; Melanoma diagnosis; Medicine; Gynecology

2026-04-15https://doi.org/10.55892/jrg.v9i20.3168Revista JRG de Estudos Acadêmicos 20261Spleen Rupture After Embolization for Visceral Mycotic Aneurysms: Case ReportGuilherme M. A. Almeida; Davi Colen; Filipe Terra; Guilherme Carvalho; Frederico Araújo; Felipe Murad

Embolization; Spleen; Splenic disease; Complication; Splenic artery; Medicine; Surgery; Radiology

2026-04-15https://doi.org/10.1016/j.jvs.2025.12.326Journal of Vascular Surgery 20261The financial market and company/stakeholder integration: past and futureABSTRACT This article presents an overview of the evolution of finance theory, which is the study of allocating scarce resources to different uses in situations of uncertainty. The article highlights three periods: classical finance, which is characterized by micro-based theories applied to the corporate environment and its relationship with the capital market; market imperfections, which can alter classical norms and are represented by financial constraints, agency costs, and control mechanisms suggested by corporate governance; and emerging themes, which are based on limited rationality and seek to incorporate decision-maker behavior into classical norms that have already been adjusted for market imperfections. Finally, it provides an overview of financial markets and company/stakeholder integration in the Accounting & Finance Review over the last few years, concluding with a reflection on the future of research in this area.Fernanda Finotti Cordeiro Perobelli

Capital market; Financial market; Corporate finance; Rationality; Agency (philosophy); Control (management); Financial capital; Reflection (computer programming); Economics; Finance; Business; Financial economics; Financial modeling; Market data

2026-01-01https://doi.org/10.1590/1808-057x2026100-3.enRevista Contabilidade & Finanças 20261MultiplexedHigh-Throughput Detection of SchistosomiasisBiomarkers Using Enhanced Nanoscale Enzymatic MetallizationAbstract Schistosomiasis is a disease caused by a helminth parasite that causes a large disease burden in endemic areas. Tests that can differentiate current infection from formerly infected and noninfected individuals in an accurate, yet simple and inexpensive manner remain a critical need for schistosomiasis control programs. Here, we present two distinct multiplexed high-throughput platforms utilizing enzymatic nanoscopic silver metallization for inexpensive optical or electronic dry readouts. The optical detection platform generates a readout simply by capturing an image with a cellphone, while the electrical detection platform uses gold nanoparticles to enhance enzymatic silver metallization, enabling a simple impedance-based electronic readout. Both platforms were optimized and compared. We determined that the optical readout could better differentiate the three distinct patient groups by infection status. A multiplexed readout version of the optical platform was then developed to measure levels of two antibody subclasses against seven distinct schistosome antigens, successfully demonstrating clear differentiation of the infection status. Overall, an inexpensive, multiplexed, and high-throughput detection method for schistosomiasis biomarkers was developed.Mallika Senthil; Hanhao Zhang; Irene Carriazo Badillo; Yasir Alnakhli; Sukwan Handali; W. Evan Secor; Lucia A. O. Fraga; Jessica K. Fairley; Aniruddh Sarkar

Schistosomiasis; Multiplexing; Nanoscopic scale; Immune system; Schistosoma; Immunoassay; Colloidal gold; Nanotechnology; Materials science; Biology; Immunology

2026-04-15https://doi.org/10.1021/acsnanoscienceau.6c00013ACS Nanoscience Au 20261Mercado financeiro e integração empresas/stakeholders: um olhar para o passado e um olhar para o futuroRESUMO Neste artigo, a evolução da teoria de finanças, área de estudo voltada à alocação de recursos escassos em fins alternativos sob condições de incerteza, é apresentada, destacando-se três momentos: as finanças clássicas, marcadas pelo advento das teorias microfundamentadas aplicadas ao ambiente corporativo e da relação desse ambiente com o mercado de capitais; as imperfeições de mercado, capazes de alterar as normativas clássicas representadas pela restrição financeira, custos de agência e mecanismos de controle sugeridos pela governança corporativa; e os temas emergentes que, baseando-se na racionalidade limitada do agente, buscam incorporar o comportamento do decisor às normativas clássicas já ajustadas pelas imperfeições de mercado. Por fim, apresenta-se um panorama da área de mercado financeiro e integração empresa/stakeholders na Revista Contabilidade & Finanças ao longo dos últimos anos, finalizando com uma provocação sobre o futuro das pesquisas na área.Fernanda Finotti Cordeiro Perobelli

Context (archaeology); Work (physics); Rationality; Field (mathematics); Order (exchange); Political science; Economics; Philosophy

2026-01-01https://doi.org/10.1590/1808-057x2026100-3.ptRevista Contabilidade & Finanças 20261A market-based approach to assessing the capacity value of variable renewable energy: Evidence from the Dominican RepublicThe growing integration of variable renewable energy (VRE) challenges traditional capacity valuation methods in electricity markets, which mainly rely on probabilistic models and technical adequacy metrics and are not linked to market design and economic incentives. This study introduces a new approach to assessing the Economic Capacity Value (ECV) of VRE resources, which measures their contribution to system reliability, considering resource availability and market conditions. The methodology is applied using a co-optimization model of the energy market and the capacity remuneration mechanism that minimizes total system costs and capacity payments. The framework is applied to the Dominican Republic's electricity market, using 2023 demand and generation data. Results show that VRE resources provide a significant contribution to system reliability under existing market conditions. Solar photovoltaic ECVs range from 21.8 MW (17.2%) in the north region to 107.2 MW (33.6%) in the southwest, while wind power exhibits higher values, reaching 87.6 MW (43.9%) in the north and 74.7 MW (34.4%) in the southwest. In all cases, ECV surpasses the capacity factor, indicating that VRE contributes more to reliability than its average production suggests. Sensitivity analysis shows that ECV is highly sensitive to market design parameters, with ±25% variations in capacity payments or scarcity prices resulting in ECV changes of up to 34%. These findings show that capacity value can be influenced by both resource availability during high demand periods and market design, supporting the inclusion of VRE in capacity remuneration mechanisms based on ECV. • A novel methodology is proposed to estimate the Economic Capacity Value (ECV) of VRE power plants. • A co-optimization model of the energy market and the capacity payments is built for the application of the methodology. • A case study estimates regional ECV of VRE in north, southwest, and southeast regions of the Dominican Republic for 2023. • Wind power plants show a higher ECV than solar photovoltaic power plants in the Dominican Republic during 2023. • All technologies across regions show an ECV that exceeds their capacity factor in 2023.René Báez-Santana; Miguel Aybar-Mejia; Máximo Domínguez-Garabitos; Víctor Samuel Ocaña Guevara; Bruno H. Dias; João Soares; Luís Hernández-Callejo

Variable (mathematics); Renewable energy; Value (mathematics); Variable renewable energy; Developing country; Economics; Natural resource economics; Econometrics; Environmental economics

2026-04-17https://doi.org/10.1016/j.egyr.2026.109300Energy Reports 20261Improved short-term streamflow forecasting in Brazilian basins using novel enhanced evolving multivariable Gaussian modelsEfficient water resource management is critical for hydropower generation and sustainable energy planning. This study investigates enhanced evolving fuzzy systems (eFS) for streamflow forecasting within the Brazilian hydrological system. Two innovative approaches are proposed by incorporating adaptive hyperparameter update mechanisms into the evolving Multivariable Gaussian (eMG) model: the Variable Step-Size Adaptive evolving Multivariable Gaussian (VSA-eMG) and the Modified Variable Step-Size evolving Multivariable Gaussian (MVS-eMG). This is the first application of these adaptive mechanisms within eFS for short-term streamflow forecasting. The models are evaluated against several benchmarks, including the operational Soil Moisture Accounting Procedure implemented by the Brazilian National System Operator (SMAP/ONS) and other data-driven evolving models. The analysis uses a nine-year dataset (2011–2019) from four strategic Brazilian basins (Furnas, Itaipu, Itumbiara, and São Simão), validated through an expanding-window scheme with seven independent 14-day folds. Results demonstrate that the proposed approaches statistically outperform non-evolving benchmarks and exhibit competitive performance compared to existing evolving models. Specifically, the MVS-eMG model achieved the best overall performance with an average Mean Absolute Percentage Error (MAPE) of 2.32% and a near-zero percent bias (0.17%). This represents an 89% reduction in forecasting error compared to the 21.29% MAPE of the operational SMAP/ONS benchmark. Statistical validation using the Morgan–Granger–Newbold (MGN) test confirmed the significance of these improvements in all tested basins. Due to their adaptive nature, the proposed models effectively handle the variability inherent in streamflow observations, demonstrating a promising balance of accuracy, computational efficiency, and adaptability for practical hydrological forecasting.Marcos V. G. da Rocha; Tiago R. Alves; Ivo C. S.

Streamflow; Multivariable calculus; Adaptability; Variable (mathematics); Gaussian; Hydropower; Artificial neural network; Water resources; Gaussian process; Computer science; Predictive modelling

2026-04-16https://doi.org/10.1007/s40899-026-01347-3Sustainable Water Resources Management 20261Mapeamento da geodiversidade presente no município de Itamarati de Minas/MGA gestão territorial eficiente depende do conhecimento dos recursos naturais e de ferramentas que integrem diferentes informações espaciais. O geoprocessamento possibilita essa integração, permitindo análises que refletem a realidade ambiental de forma mais completa. Nesse contexto, a Geodiversidade surge como uma abordagem capaz de relacionar os elementos geológicos, geomorfológicos, pedológicos, altimétricos e de uso e cobertura do solo, revelando a variabilidade dos componentes naturais de um território. Este estudo realizou o cálculo do índice de Geodiversidade para o município de Itamarati de Minas (MG), utilizando dados secundários de bases estaduais e federais. Foram analisadas as classes de Litologia, Pedologia, Geomorfologia, Hipsometria, Declividade e Uso e Cobertura do Solo. Os resultados indicaram que, embora as classes com maior área, como pastagens e formações florestais, apresentem baixos índices ponderados, as classes de menor extensão (especialmente Afloramento Rochoso e Áreas Úmidas) registraram os maiores valores de Geodiversidade Ponderada. Esses ambientes se destacam por sua relevância ecológica e potencial para ações de geoconservação e ecoturismo, contribuindo para a valorização dos recursos naturais locais. Conclui-se que a metodologia aplicada permitiu compreender a complexidade da paisagem de Itamarati de Minas e oferece subsídios para um planejamento ambiental mais integrado e sensível às particularidades do território.Diogo Parreira Lapa; Cézar Henrique Barra Rocha

Geoprocessing; Identification (biology); Work (physics); Training (meteorology); Geography; Humanities; Political science

2026-04-16https://doi.org/10.51359/2238-6211.2026.268435Revista de Geografia 20261Bruna Lins: A ascensão dos microinfluenciadores digitais no endosso de marcasGestores de grandes marcas têm direcionado seus investimentos de marketing para os nano e microinfluenciadores digitais. Nesse contexto, a narrativa deste caso gira em torno da trajetória de Bruna Lins, uma microinfluenciadora que, após firmar parcerias com marcas locais, recebe uma proposta para endossar uma grande marca nacional que reconheceu em sua credibilidade e autenticidade, fatores favoráveis à parceria. A carreira de Bruna leva o aluno a conhecer as características e o contexto dos microinfluenciadores digitais, enquanto suas incertezas quanto à nova oportunidade de endosso instigam o aluno a analisar os fatores que impulsionam o sucesso da parceria entre microinfluenciadores e marcas, avaliar os impactos dessa parceria, verificar como o marketing de influência digital impacta as atitudes do público e estabelecer critérios para que os gestores de marcas selecionem microinfluenciadores digitais. Recomenda-se a utilização deste caso nas disciplinas que abordam estratégias digitais de marketing.Ana Clara Pereira Aguilar; Stela Cristina Hott Corrêa

Context (archaeology); Taste; Work (physics); Appropriation; Humanities; Art; Political science

2026-03-31https://doi.org/10.12660/gvcasos.v16.n1.93258Revista Brasileira de Casos de Ensino em Administração 20261Óbitos por doenças respiratórias infecciosas na população indígena: análise espacial e de séries temporais, Minas Gerais, 2000-2023Resumo Objetivo Analisar a tendência temporal e a distribuição espacial dos óbitos por doenças respiratórias infecciosas em população indígena residente em Minas Gerais, Brasil, entre 2000 e 2023. Métodos Análise de séries temporais e múltiplos grupos dos óbitos registrados no Sistema de Informação sobre Mortalidade, codificados pela causa básica de morte como doenças respiratórias infecciosas pela Classificação Internacional de Doenças. O número de óbitos foi calculado segundo características demográficas e clínicas. Na análise de tendência, utilizou-se o modelo de regressão por pontos de inflexão (Joinpoint regression), calculando-se a variação percentual anual (VPA), e para análise espacial, usou-se Índice de Moran global e local. Resultados Foram registrados 271 óbitos, atingindo majoritariamente pessoas do sexo feminino (51,7%), viúvos (30,3%), com baixa escolaridade (49,1%) e idosos (62,7%). Em 65,3% dos casos, a infecção atingiu o trato respiratório inferior, e em 53,5% o agente etiológico não foi especificado. Macrorregiões de saúde exibiram padrão de queda nos óbitos entre 2020 e 2023, dos quais, Centro (VPA -6,1), Leste (VPA -38,3) e Norte (VPA -25,0). A análise espacial por quadrantes de Moran evidenciou aglomerações significativas de óbitos em São João das Missões, Belo Horizonte e Bertópolis. Conclusão Os resultados evidenciaram alto número de óbitos entre idosos, com expressivas desigualdades temporais e territoriais. Políticas públicas específicas e permanentes são necessárias, visando prevenção e acesso equitativo aos serviços de saúde para os povos originários, com melhorias nos sistemas de informação de saúde.Paulo Filipe Silva Siqueira; Daví Barbosa Pereira de Sousa; Ana Flávia Gamarano Moreira; Brian dos Santos Marchi; Guilherme da Costa Teixeira; Patrícia Ferraz Martins; Waneska Alexandra Alves

Geoprocessing; Urban environment; Population

2026-01-01https://doi.org/10.1590/s2237-96222026v35e20250565.ptEpidemiologia e Serviços de Saúde 20261Religiousness/spirituality, Depressive Symptoms, Anxiety, Hope, and Happiness in Children and Adolescents in Institutional CareAbstract There are 34 thousand children living in institutions in Brazil, a context that poses a risk to mental health, raising the need to investigate protective factors. Objective: investigate the prevalence of religiosity/spirituality and mental health (depressive and anxiety symptoms, hope, and happiness) in children and adolescents in institutions. Method: A cross-sectional quantitative study that invited all children aged 7 to 17 years in institutional care in Juiz de Fora (MG). A sociodemographic questionnaire, BMMRS (Brief Multidimensional Measure of Religiosity/Spirituality), Subjective Happiness Scale, Generalized Anxiety Disorder (GAD-7), Children's Depression Inventory (CDI), and Herth Hope Scale were used. Results: The sample consisted of 43 subjects (28 males), with a mean age of 13 years (± 2 SD). Most of the sample had moderate anxiety and indicative depressive symptoms. In addition, they had below-average happiness scores and high hope. There was a high prevalence of religion and spirituality. The mean scores were: 11 (± 5) for anxiety, with 56% ( n =24) above the clinical cutoff point; 17 for depression (± 11), with 44% of subjects above the clinical cutoff point; 4.7 (± 1) for happiness; and 36 (± 5) for hope. On the values/beliefs subscale, 95% ( n =41) agreed with the statement “I believe in a God who cares for me.” On the global self-assessment subscale, 76% ( n =33) responded that religion and spirituality were important to them. When asked what was considered most important in their lives, 52% (n=22) answered God. Conclusion: children and adolescents in care attributed great importance to spirituality and religiosity in their lives, with a relatively high prevalence of hope and below average happiness, requiring attention to clinically significant scores of depression and anxiety.Victoria Regia Duarte de Matos; Márcia Helena Fávero de Souza; Alexander Moreira‐Almeida

Religiosity; Happiness; Mental health; Anxiety; Depression (economics); Context (archaeology); Spirituality; Scale (ratio); Psychology; Clinical psychology; Psychiatry; Mental health care; Depressive symptoms; Sample (material)

2026-04-17https://doi.org/10.1007/s41603-026-00335-xInternational Journal of Latin American Religions 20261High-biodiversity areas require accurate investigations: a reply to Pires & Sobczak (2025) on the terrestrial vertebrate fauna of the Serra de Baturité Environmental Protection AreaAbstract Humid forest enclaves in mountainous areas of northeastern Brazil harbor a distinct biota from the surrounding dry vegetation, with stronger affinities to Amazonian and Atlantic species, such as the Serra de Baturité Environmental Protection Area (SBEPA), in the Ceará state. Although the region has been the focus of various scientific studies, only a few provided comprehensive data on its biodiversity. Aiming to fill in this gap, Pires & Sobczak (2025) published a broad compilation of species records within the SBEPA, covering multiple biological groups. Despite its relevance, we identified numerous mistakes, inconsistencies, and omissions related to terrestrial vertebrates. Here, we highlight major issues in this article, such as the use of outdated taxonomic frameworks, inflated species lists, the inclusion of species not known to occur in the region, and the omission of species with confirmed presence. We present a corrected list for terrestrial vertebrates of the SBEPA, using the same temporal frame of the original article. We also discuss species conservation status, endemism, exotic species occurrence, and the inappropriate use of bibliographic references.Aldo Caccavo; Marco Aurélio Crozariol; Hugo Fernandes‐Ferreira; Déborah Praciano de Castro; Thabata Cavalcante; Fernando Heberson Menezes; Hipólito Denizard Ferreira Xavier; Daniel Cassiano-Lima; Antonio Robério G. Freire-Filho; Rodrigo Castellari Gonzalez

Fauna; Biota; Vertebrate; Atlantic forest; Biodiversity; Wildlife; Amazonian; Geography; Ecology; Mammal

2026-01-01https://doi.org/10.1590/1676-0611-bn-2025-1840Biota Neotropica 20261Convolutional Neural Networks for Energy Estimation in High-Energy CalorimetryParticle accelerators are complex facilities that collide particles at extreme high speed, aiming at discovering new physics. In this context, high-energy calorimeter systems plays a crucial role as it provides the particle energy quantity that is an important information for the potential new discoveries. This work evaluates the performance of the Optimal Filter (OF) method and several Convolutional Neural Network (CNN) architectures in reconstructing the amplitude of simulated signals that represent the response pulses produced by calorimeters in high-energy physics experiments. The comparison is conducted using quantitative metrics — including RMS, MAE, MedAE, and Coefficient of Determination. The results show that different CNN architectures exhibit varying performance depending on the occupancy rate but generally outperform the commonly used linear method, providing more accurate reconstructions. Although the proposed requires a large execution time due to the training process across multiple folds, these findings indicate that CNNs are promising alternatives for calorimeter energy reconstruction, particularly in high-occupancy conditions as the ones expected for high-luminosity experiments.Diogo Alves Cardinot; B. S. Peralva; Gustavo Barbosa Libotte; Luciano de Manhães Andrade Filho

Energy (signal processing); Convolutional neural network; Artificial neural network; Feature (linguistics); Calorimetry; Pattern recognition (psychology); Algorithm; Computer science; Artificial intelligence; Field (mathematics); Estimation theory; Mathematics

2026-03-17https://doi.org/10.1109/lats70329.2026.11480323 20261Valorização Integral dos Alimentos: Desenvolvimento, composição nutricional e análise sensorial de preparaçõesO Aproveitamento Integral dos Alimentos (AIA) consiste no uso total dos alimentos, incluindo partes normalmente descartadas. Um aspecto central para a valorização do AIA é tratar essas partes não convencionais como produtos, e não apenas como subprodutos. Integrá-las nas receitas desde o primeiro uso aumenta a praticidade, evidencia seu valor e pode favorecer sua aceitação e consumo. Foram elaboradas 10 preparações utilizando frutas e hortaliças. A composição centesimal foi determinada com base nas tabelas brasileiras de composição de alimentos e nos rótulos de alimentos. A análise sensorial foi realizada com avaliadores, utilizando escala hedônica de nove pontos para cor, aroma, sabor, textura e impressão global. Os dados foram analisados no software SPSS, com nível de significância de p<0,05. O valor calórico variou entre 126,98 kcal e 348,62 kcal. O bolo de laranja destacou-se em carboidratos (51,28 g.100g⁻¹), a flor de batata inglesa ao molho de parmesão em lipídeos (25,4 g.100 g⁻¹) e o charuto de couve em proteínas (9,54 g.100g⁻¹). O bolo de brócolis destacou-se em cálcio (236,43 mg.100g⁻¹) e ferro (2,32 mg.100g⁻¹). O charuto de couve apresentou maiores teores de fibras (3,01 g.100g⁻¹), vitaminas, potássio e zinco. Todas as preparações tiveram notas superiores a 7 (gostei moderadamente) na escala hedônica e índice de aceitabilidade acima de 75%, sendo que o escondidinho de banana-da-terra foi a preparação com maior índice (91,89%). As preparações desenvolvidas utilizando as partes não convencionais das frutas e hortaliças apresentaram alta aceitação pelos provadores, podendo ser uma estratégia para tornar a alimentação mais nutritiva e sustentável.Mariana de Melo Cazal; Isabelle Sodré de Carvalho Milani; Bruna Késia Dias Bicalho; Sandra Tavares da Silva; Kellem Regina Rosendo Vincha

Nutritional science; Significant difference; Food consumption; Base (topology); Physics; Food science; Humanities; Mathematics

2026-04-16https://doi.org/10.14808/sci.plena.2026.031502Scientia Plena 20261Case Study: The High-Level Synthesis-Based Firmware Upgrade for the Digital Trigger Back-End System of the ATLAS Liquid Argon CalorimeterThe trigger and data acquisition systems of the LHC experiments rely on reconfigurable architectures based on FPGA (Field Programmable Gate Arrays) to accommodate design updates and increasing of the detectors complexity. However, this flexibility comes at the cost of longer development and validation cycles, particularly for large real-time systems operating under strict latency and throughput constraints. This work presents the HLS-based firmware redesign of the back-end system from the ATLAS Liquid Argon Calorimeter, where the introduction of a parallel switch matrix on REMAP block significantly simplifies the architecture and reduces the use of firmware resources. The proposed methodology allows systematic design exploration without modifying the source code, shortens verification time, and provides a more efficient workflow for creating and maintaining large-scale FPGA firmware in modern trigger systems.Melissa S. Aguiar; Dabson F. dos Santos; Adriana Milic; Diogo A. Cardinot; Marcos V. S. Oliveira; Luciano de Manhães Andrade Filho; Gustavo B. Libotte; Bernardo S. Peralva

Firmware; Upgrade; Atlas (anatomy); Calorimeter (particle physics); Software; Large Hadron Collider; Physics; Computer science; Computer hardware; Nuclear engineering; Engineering; Data acquisition

2026-03-17https://doi.org/10.1109/lats70329.2026.11480279 20261Clinical Applications and Case StudiesApproaches that are based on Artificial Intelligence (AI) are widely used day by day in various fields, For example, in the industry of eliminating environmental pollution, i.e. modeling the adsorption of methylene blue dye on Ho-CaWO4 nanoparticles utilizing RSM (Response Surface Methodology) and ANN (Artificial Neural Network) techniques and other aspects especially medicine and life science. Artificial intelligence to optimize drug delivery systems based on nanocarriers will change the landscape of personalized cancer treatment. AI-enhanced nanocarriers by combining machine learning algorithms and nanotechnology offer significant potential in improving the accuracy and efficiency of cancer treatments. These systems advance toward personalized treatment strategies by providing sophisticated analyzes of biological data, predicting patient responses, and optimizing drug release. Management of complex oncological cases, such as multidrug-resistant tumors with the possibility of real-time monitoring, adaptive therapy, and precise targeting of cancer cells while minimizing possible side effects, can be achieved through the synergy between nanocarriers and AI. Furthermore, AI can significantly influence the interactions between nanomedicine and tumor cells, including aspects such as the response of the tumor microenvironment, the process of internalization, therapeutic effects, and the distribution within cells. The prediction of interactions among pharmaceuticals, nanocarriers, biological mediators, and cell membranes, along with the assessment of effectiveness of drug encapsulation and the modeling of kinetics of drug release from nanocarriers using AI procedures, facilitates the development of optimal pharmaceutical formulations that maximize drug transfer and targeting efficacy. Approaches activated with AI make it possible to choose optimal drug combinations and introduce global combination therapy to enhance drug synergy, minimize toxicity, and ultimately lead to improved clinical outcomes. Furthermore, machine learning (ML) algorithms can assist nanoscale sensors in identifying novel biomarkers and clinical targets, differentiating between patients and healthy individuals, as well as forecasting disease outbreaks or relapses.Roghaieh Holghoomi; Abbas Rahdar; Renato Nery Soriano

Nanocarriers; Nanomedicine; Drug delivery; Personalized medicine; Drug; Targeted drug delivery; Artificial neural network; Computer science; Artificial intelligence; Nanotechnology; Biochemical engineering; Cancer treatment; Precision medicine; Process (computing); Machine learning

2026-04-17https://doi.org/10.1002/9781394384891.ch9 20261Deaths from infectious respiratory diseases in the Indigenous population: spatial and time series analysis, Minas Gerais, 2000–2023Abstract Objective To analyze the temporal trend and spatial distribution of deaths from respiratory tract infections in the Indigenous population residing in Minas Gerais, Brazil, between 2000 and 2023. Methods Methods Time-series and multiple-group analysis of deaths recorded in the Brazilian Mortality Information System (Sistema de Informação sobre Mortalidade, SIM), coded according to the underlying cause of death as respiratory tract infections based on the International Classification of Diseases (ICD). The number of deaths was calculated according to demographic and clinical characteristics. In the trend analysis, the Joinpoint regression model was used to estimate the annual percent change (APC), and for spatial analysis, the global and local Moran’s I indices were applied. Results A total of 271 deaths were recorded, predominantly affecting females (51.7%), widowed individuals (30.3%), those with low educational level (49.1%), and older adults (62.7%). In 65.3% of cases, the infection affected the lower respiratory tract, and in 53.5% of cases, the etiologic agent was unspecified. Health macroregions exhibited a downward trend in deaths between 2020 and 2023, namely Central (APC -6.1), East (APC -38.3), and North (APC -25.0). Spatial analysis using Moran’s quadrants identified significant clusters of deaths in São João das Missões, Belo Horizonte, and Bertópolis. Conclusion The results demonstrated a high number of deaths among older adults, with marked temporal and territorial inequalities. Specific and sustained public policies are needed to prevent health inequities and ensure equitable access to health services for Indigenous Peoples, alongside improvements to health information systems.Paulo Filipe Silva Siqueira; Daví Barbosa Pereira de Sousa; Ana Flávia Gamarano Moreira; Brian dos Santos Marchi; Guilherme da Costa Teixeira; Patrícia Ferraz Martins; Waneska Alexandra Alves

Indigenous; Public health; Population; Epidemiology; Respiratory tract infections; Trend analysis; Cause of death; Ecological study; Demography; Medicine; Environmental health; Geography; Time series; Health services

2026-01-01https://doi.org/10.1590/s2237-96222026v35e20250565.enEpidemiologia e Serviços de Saúde 20261Artificial Intelligence (AI)‐Enabled Nanocarriers in Cancer DiagnosisIn recent years, nanotechnology has significantly advanced, offering new methods for the early detection and treatment of cancer. Nanocarriers, utilized for precisely delivering drugs and cancer biomarkers to target cells, have revolutionized this field thanks to substantial progress in artificial intelligence (AI). AI algorithms, including machine learning and neural networks, process and analyze the data derived from these nanocarriers. This technology enhances molecular profiling precision, increases the speed and sensitivity of early cancer diagnosis, and aids clinicians in developing personalized and more effective treatments for cancer patients. These nanoparticles have the ability to detect biomolecules at extremely low concentrations, enabling the diagnosis of small tumors and early metastases. In addition, the capacity of artificial intelligence to analyze large datasets can increase the nanomedicines accuracy, contributing to the development of more effective, precise targeted nanomedicines, and reducing side effects. This chapter delves into the application of artificial intelligence in accurate cancer diagnosis, emphasizing the role of nanocarriers in cancer biomarker extraction and artificial intelligence-based advances in biosensing for cancer diagnosis. The synergy between nanotechnology and AI not only opens up new ways for cancer diagnosis and therapy, but also supports the emergence of more individualized treatment strategies.Zakieh Sadat Hoseini; Amir Mohammad Najafi; Fatemeh Nouri Rouzbahani; Renato Nery Soriano; Abbas Rahdar

Cancer; Nanocarriers; Applications of artificial intelligence; Artificial neural network; Disease; Medicine; Artificial intelligence; Computer science

2026-04-17https://doi.org/10.1002/9781394384891.ch7 20261Pacientes com doença renal crônica estágio 3b: médicos generalistas e nefrologistas seguem as diretrizes da KDIGO?Resumo Introdução: O encaminhamento e o manejo adequados de pacientes com DRC da atenção primária à nefrologia são fundamentais para prevenir complicações e a progressão da doença. Objetivos: Descrever características demográficas e de acompanhamento de pacientes com DRC estágio 3b no momento do encaminhamento, o cuidado oferecido por generalistas e a assistência inicial por nefrologistas no Sistema Único de Saúde (SUS). Métodos: Coorte retrospectiva incluindo todos os pacientes com DRC estágio 3b na lista de espera para consulta nefrológica entre janeiro de 2018 e janeiro de 2020, em uma grande cidade do sudeste do Brasil. Foram avaliados dados sociodemográficos, comorbidades e adesão às recomendações de acompanhamento segundo Kidney Disease: Improving Global Outcomes (KDIGO) 2021. Os pedidos e resultados de exames laboratoriais foram comparados entre os períodos de atendimento pelo clínico geral e após consulta nefrológica. Resultados: Um total de 211 pacientes (idade média de 74 ± 12 anos) foram incluídos; 76% eram hipertensos e 46,9%, diabéticos. Cerca de metade realizou número adequado de consultas na atenção básica. O monitoramento laboratorial foi subótimo tanto na atenção primária quanto no cuidado especializado. Antes da nefrologia, exames de dosagem de hemoglobina e exames de urina estavam disponíveis em 32,2% e 19,4% dos pacientes, respectivamente. Após a consulta especializada, hemoglobina e potássio foram registrados para 68,3% e 58,8% dos pacientes, respectivamente. Conclusão: Embora os pacientes com DRC estágio 3b fossem acompanhados regularmente, a baixa adesão às recomendações de testes da KDIGO levanta preocupações quanto à adequação do cuidado. Fortalecer a comunicação e a implementação das diretrizes entre a atenção primária e os serviços de nefrologia é fundamental para aprimorar o manejo da DRC no âmbito do SUS.Juliana Gazzi Macedo; Alessandra Maciel Almeida; Helady Sanders‐Pinheiro; R. A. Fabreti‐Oliveira

Medical screening; Kidney disease; Medical record; Congenital disease; Cohort; Medicine; Gynecology

2026-01-01https://doi.org/10.1590/2175-8239-jbn-2025-0229ptBrazilian Journal of Nephrology 20261In silico structural analysis of EthA substitutions for ranking priority mutations leading to ethionamide resistance in Mycobacterium tuberculosisAbstract Background Tuberculosis (TB) is the second-leading cause of deaths from infectious agents and remains a global health threat. Ethionamide (ETH) is a prodrug used in regimens for multidrug-resistant TB, and, partly due to side effects that can lead to low treatment adhesion, resistance arises. Changes in EthA, the monooxygenase that activates ETH, are the main mechanism of resistance. Yet, of hundreds of EthA substitutions found in resistant isolates, only a handful have been annotated as resistance determinants. Results An in silico analysis was carried out on a previously described panel of Mycobacterium tuberculosis clinical isolates for which genomes and ETH susceptibility testing results were available. EthA substitutions were mapped, revealing the existence of hotspots in its sequence. Visualization of the hotspots in the EthA structural model shows that they cluster in three regions, including ligand binding pockets. Models were built of twenty-three variants found in resistant isolates and changes in local configuration was mapped to identify investigate impact on ETH activation. Information from these models contributed to establishing five criteria for scoring whether substitutions are most likely to lead to resistance. Using these criteria, EthA D58G was selected and its expression is shown to increase growth in high ETH concentrations. Conclusion Functionally relevant regions of EthA are revealed and point out priority substitutions for functional studies, enhancing identification and detection of substitutions not been previously associated with resistance.Rodrigo Fernandes Machado; Sophia Lincoln Cardoso; Isabela Cordeiro Pinheiro; Jesus Pais Ramos; Caetano Antunes; Priscila Capriles; Teca Calcagno Galvão

In silico; Mycobacterium tuberculosis; Ethionamide; Tuberculosis; Genome; Extensively drug-resistant tuberculosis; Rifampicin; Genetics; Computational biology; Biology; Drug resistance; Mutation; Point mutation

2026-04-17https://doi.org/10.64898/2026.04.16.718980bioRxiv (Cold Spring Harbor Laboratory) 20261The Matoli tradition from ritual practice to regenerative tourism: biodiversity, gastronomy, and social reproduction in Ganesh Chaturthi (Goa, India)The celebration of Ganesh Chaturthi in India, particularly in Goa, is closely linked to cultural practices that reflect the region’s heritage, traditional values, and ecological awareness. Central to these practices is the Matoli, a decorative canopy composed of locally sourced herbs, fruits, roots, and shrubs, which symbolizes the community’s relationship with its natural environment and connects culinary customs to ritual practices. This study examines how the collection of Matoli elements, in Ganesh Chaturthi, and the preparation of festive foods contribute to biodiversity awareness, community participation, and social cohesion. Drawing on cultural ecology theory, the research adopts a qualitative-dominant mixed-methods approach, combining ethnographic fieldwork, botanical surveys, and semi-structured interviews with local stakeholders. The findings indicate that Matoli functions as an eco-cultural practice that simultaneously preserves biodiversity knowledge, reinforces intergenerational transmission, and strengthens community bonds. Furthermore, the study demonstrates that integrating Matoli-related practices into tourism can support regenerative, community-centered development. Aligned with the Convivialist Manifesto (https://convivialism.org/), we argue that tourism should coexist with host societies without structurally altering or subordinating them, operating instead within a post-neoliberal convivialist logic. By articulating the interconnections between tradition, biodiversity, and gastronomy, the study contributes to advancing regenerative tourism approaches grounded in cultural and ecological sustainability.Chaitali Chandrakant Tendulkar; Subhash Kizhakanveatil Bhaskaran Pillai; Thiago Duarte Pimentel; K. G. Sankaranarayanan

Ethnography; Tourism; Manifesto; Reproduction; Social practice; Biodiversity; Natural (archaeology); Sociology; Environmental ethics; Anthropology; Ecology; Social science

2026-04-19https://doi.org/10.31822/jomat.2026-11-1-119Journal of Multidisciplinary Academic Tourism 20261Comparative Efficacy and Safety of Encorafenib and Binimetinib in First-Line Versus Post-Immunotherapy for BRAFV600-Mutant Metastatic Melanoma: A Systematic Review and Meta-AnalysisN.M. Neves; C.L. Dias; P.R.M. Santos; G. Perrone; V.C. De Siervi

MEDLINE; Clinical trial; Alternative medicine; Disease; Medicine; Marketing; Intensive care medicine; Business; Environmental health

2026-01-01https://doi.org/10.1016/j.ejcskn.2026.100812EJC Skin Cancer 20261Aesthetic rehabilitation in mesiodents until the eruption of permanent successors: importance of monitoring in a case reportABSTRACT Mesiodens are supernumerary teeth located in the anterior maxilla region, often with a conical crown and short root. Their presence may compromise occlusion, esthetics, and the eruption path of permanent incisors, representing both functional and psychosocial challenges in early childhood. The aim was to report a pediatric dentistry case of conservative management of mesiodens through esthetic rehabilitation and systematic clinical monitoring until the optimal timing for extraction. A 4-year-old boy presented with two conoid mesiodens in the anterior maxilla region. Instead of immediate extraction, a conservative approach was adopted, consisting of esthetic rehabilitation using prefabricated acetate crowns and continuous clinical and radiographic follow-up. This strategy ensured satisfactory esthetics, preserved function, and promoted the child’s psychosocial well-being during a critical stage of development. The case highlights the importance of individualized treatment planning in pediatric dentistry. Early diagnosis and conservative rehabilitation can provide temporary but significant esthetic and emotional benefits, while delaying surgical intervention until the ideal moment facilitates proper eruption of permanent successors. Conservative rehabilitation of mesiodens, associated with systematic monitoring, represents a valuable therapeutic approach. Beyond preserving function and esthetics, it supports psychosocial development and improves quality of life, highlighting the relevance of treatment timing in pediatric patients.João Pedro Franco Neves; Ranam Moreira Reis; Fabíola Galbiatti de Carvalho Carlo; Janaína Cristina Gomes

Rehabilitation; Psychosocial; Conservative treatment; Anterior maxilla; Intervention (counseling); Anterior teeth; Medicine; Orthodontics; Maxilla; Dental trauma; Dentistry; Conservative management

2026-01-01https://doi.org/10.1590/1981-86372026001020250121RGO - Revista Gaúcha de Odontologia 20261The impact of Airbnb on the spatial distribution of economic activityLuiz Pedro Couto Santos Silva; Fernando Salgueiro Perobelli; Rafael H. M. Pereira

Renting; Economies of agglomeration; Spillover effect; Incentive; Distribution (mathematics); Spatial dispersion; Spatial distribution; Instrumental variable; Economic impact analysis; Economics; Economic geography; Labour economics; Panel data; Spatial econometrics; Dispersion (optics); Income distribution; Business; Spatial analysis; Spatial dependence; Econometrics

2026-01-01https://doi.org/10.2139/ssrn.6536438SSRN Electronic Journal 20261Surgical Treatment of Saccular Extracranial Carotid Artery AneurysmExtracranial carotid artery aneurysms (ECAAs) are an increase of 50% or more in the diameter of the carotid artery and classified by location. They are rare and most are located in the internal carotid artery or carotid bifurcation. Diagnosis is incidental or by the presentation of a pulsatile neck mass or neurological symptoms. There are no universal recommendations regarding its treatment. Male, 72 years old, with a pulsatile cervical mass on the left. No history of previous trauma. Angioresonance and angiography identified a saccular aneurysm in the carotid bulb, measuring 1 × 0.7 cm. Referred for open surgical treatment, which was performed under general anesthesia and by longitudinal anterior cervicotomy, endoaneurysmorrhaphy, and bovine pericardium patch. There was an uneventful postoperative recovery and hospital discharge on the 3rd postoperative day. ECAAs represent between 0.4% and 1.9% of all peripheral aneurysms. They are more prevalent in men, with an average age at diagnosis of 53 ± 17 years. They can be divided into fusiform or saccular. The most common etiology of ECAA is atherosclerosis (50% of cases). ECAAs can be classified according to Attigah into Types I to V, based on the segment involved. Half of the patients with ECAAs have symptoms at diagnosis. Presentation may include a pulsatile neck mass, cervical discomfort, headache, stroke, or neurological deficits. Although rare, rupture can occur. The indication for correction of ECAAs is based on the risk of cerebral ischemia. Duplex ultrasound is the first option for diagnosis. Angiotomography, angioresonance, and angiography are options as confirmatory examinations. The techniques for repairing ECAAs are endovascular, hybrid or open: stents, embolization, or correction by arterial resection and reconstruction or patch. ECAAs are rare and have potential complications due to cerebral thromboembolism. ECAA repair is possible through open or endovascular techniques.Henrique Salles Barbosa; Renata Salles Barbosa; Aline Cristina Pavani; Renata Sydio de Souza; Marina Tambasco Freire Vicente; Mariana Fernandes Carvalho

Pulsatile flow; Neck mass; Etiology; Saccular aneurysm; Presentation (obstetrics); Aneurysm; Ultrasound; Angiography; Medicine; Radiology; Internal carotid artery; Surgery; Cerebral angiography; Carotid arteries; Computed tomography angiography; Fusiform Aneurysm; External carotid artery; Common carotid artery; Artery; Stroke (engine); Carotid bifurcation

2026-01-01https://doi.org/10.1155/carm/4459572Case Reports in Medicine 20261Translation, cross-cultural adaptation and psychometric validation of the self-efficacy scale for physical education teacher education majors toward children with disabilities for Brazilian PortugueseIntroduction: The participation of people with disabilities (PWD) in physical activity and sports is essential for social inclusion and health promotion. The self-efficacy perceived by professionals greatly influences the success of inclusive practices; higher confidence in adapting activities and addressing diverse needs leads to better experiences for PWD. The self-efficacy scale for physical education teacher education majors toward children with disabilities (SE-PETE-D) measures this construct but lacked a validated Brazilian version. Objective: To translate, culturally adapt, and validate the Brazilian Portuguese version, named EAE-EFI/Brazil. Results: > 0.96). Confirmatory factor analysis showed acceptable model fit (RMSEA <0.10; CFI, TLI, IFI > 0.90), supporting the original structure for subscales related to physical disability (PD) and visual impairment (VI). Conclusion: The EAE-EFI/Brazil is a valid and reliable tool for assessing physical education teachers' and students' self-efficacy concerning inclusion of individuals with intellectual disabilities, PD, and VI in Brazil. Future studies should evaluate the scale's applicability in diverse contexts and explore links with professional development and institutional support, advancing inclusive practices and policies in Brazilian education.Renato de Carvalho Guerreiro; Ciro Winckler; Raphael Moreira de Almeida; Martin E. Block; Andressa Silva

Physical education; Portuguese; Scale (ratio); Exploratory factor analysis; Confirmatory factor analysis; Inclusion (mineral); Construct validity; Construct (python library); Adaptation (eye); Psychology; Concurrent validity; Internal consistency; Psychometrics; Teacher education; Applied psychology; Developmental psychology; Rating scale; Special education; Clinical psychology; Medical education; Exploratory research; Intellectual disability; Test validity

2026-04-20https://doi.org/10.3389/fpsyg.2026.1782205Frontiers in Psychology 20261ARTICULAÇÃO INTERSETORIAL ENTRE EDUCAÇÃO, SAÚDE E POLÍTICAS PÚBLICAS: CAMINHOS INSTITUCIONAIS PARA A REDUÇÃO DAS DESIGUALDADES E PROMOÇÃO DA EQUIDADE SOCIAL NO BRASILA persistência das desigualdades sociais no Brasil evidencia os limites de políticas públicas formuladas e executadas de modo fragmentado. Em contextos marcados por vulnerabilidades territoriais, desigualdades raciais, precariedade de renda e acesso desigual a direitos, a ação estatal setorial tende a produzir respostas parciais para problemas cuja gênese e reprodução são estruturalmente multidimensionais. Este artigo analisa a articulação entre educação, saúde e gestão pública como estratégia para a promoção da equidade social no Brasil. Adota-se uma revisão sistemática qualitativa, de natureza analítico-reflexiva e documental, fundamentada em referenciais da Saúde Coletiva, das Políticas Públicas e da Educação, com ênfase em estudos sobre intersetorialidade, determinantes sociais da saúde, governança colaborativa e experiências brasileiras de integração entre setores. Os resultados indicam que a intersetorialidade, quando sustentada por planejamento compartilhado, pactuação institucional, territorialização, monitoramento e corresponsabilização entre atores, amplia a capacidade do Estado de enfrentar vulnerabilidades complexas e de produzir respostas mais integrais. A análise do Programa Saúde na Escola e de estudos sobre gestão intersetorial mostra que a articulação entre educação e saúde constitui experiência relevante, mas ainda atravessada por obstáculos como fragmentação administrativa, baixa institucionalização, dificuldades de coordenação federativa, assimetrias de poder entre setores e insuficiência de avaliação integrada. Conclui-se que a intersetorialidade não deve ser tratada apenas como princípio abstrato de boa gestão, mas como prática indispensável à efetivação de direitos sociais e à redução de desigualdades persistentes. Sua consolidação depende de capacidade estatal, governança colaborativa, financiamento, mecanismos de avaliação e compromisso político com a integralidade e a justiça social.Fernanda Nascimento Almeida; Líliam Dos Reis Lopes; Jusele de Souza Matos; Fernanda Resende Gonçalves; Sergialyson Brasil Farias; Mirella Claudino Oliveira Silva; Adriana Aparecida De Arruda Santos; Luiz Eduardo de Almeida; Valéria de Oliveira; Gleisson Carlos Borges Novais; Pablo Rodrigo de Oliveira Silva

Inequality; State (computer science); Equity (law); Context (archaeology); Field (mathematics); Perspective (graphical); Social inequality; Government (linguistics); Sociology; Political science; Welfare economics

2026-04-21https://doi.org/10.70773/revistatopicos/776787753Revista Tópicos. 20261O PLANEJAMENTO NA ORGANIZAÇÃO DO TRABALHO DOCENTE: DA PRESCRIÇÃO CURRICULAR À AUTONOMIA PEDAGÓGICAO planejamento escolar consiste em organizar e ajustar intencionalmente as ações pedagógicas, sendo um processo contínuo de reflexão que orienta a prática docente e articula o trabalho educativo às dimensões sociais e políticas da educação, indo além da burocracia e se configurando como um ato político-pedagógico. Esta pesquisa visa analisar o planejamento escolar como instrumento de organização do trabalho docente, discutindo seus limites e possibilidades frente às exigências curriculares e à autonomia profissional do professor. A metodologia adotada é de abordagem qualitativa, fundamentada em estudos como os de Luckesi (2005) e Libâneo (2008). Os resultados mostram que o planejamento escolar se configura como uma prática intencional, reflexiva e não neutra, essencial para a organização do ensino e para a promoção de aprendizagens significativas. Contudo, também se identificam limites relacionados às prescrições curriculares, às condições de trabalho docente e à tendência de redução do planejamento a uma atividade burocrática. Por outro lado, destacam-se possibilidades de ressignificação dessa prática, especialmente quando desenvolvida de forma coletiva, contextualizada e comprometida com a realidade dos estudantes, favorecendo a autonomia pedagógica e a construção de práticas mais inclusivas e democráticas. Conclui-se que o planejamento escolar se apresenta como um espaço de desafios e possibilidades, cuja efetividade depende tanto das condições institucionais quanto da atuação crítica e reflexiva dos professores.Carlos Daniel Chaves Mourão; Maria das Graças dos Santos; Gabriel da Silva Monteiro; Yêda Sá Malta; Maria José Soares Genuíno; Katywsse Alves de Carvalho; Katia Maria Rodrigues Costa; Manfrede Fonseca Da Silva; Geovânio Felipe Oliveira Martins; Jaíris Lima Demontiez Silva

Context (archaeology); Work (physics); Autonomy; Curriculum; Face (sociological concept); Humanities; Sociology; Pedagogy; Political science

2026-04-20https://doi.org/10.51891/rease.v12i4.25918Revista Ibero-Americana de Humanidades, Ciências e Educação 20261Opção por usinas a gás revela contradição do Brasil com metas de mitigação climáticaAo priorizar combustíveis fósseis em detrimento de alternativas renováveis já competitivas, o Brasil sinaliza um afastamento das trajetórias necessárias para limitar o aquecimento global e reduzir vulnerabilidades socioambientaisHirdan Costa; George Mendes; Joana Nascimento; Joubert Marques

Context (archaeology); Work (physics); Process (computing); Quality (philosophy)

2026-04-21https://doi.org/10.64628/ade.m9awa4t5r 20261Latent Heterogeneity in Depressive Symptoms, Suicidal Thoughts and Behaviors Among Brazilian Medical Students: Prevalence, Associated Factors, and Group DifferencesOBJECTIVE: Suicidal thoughts and behaviors (STBs) are common among medical students, but larger, diverse studies are needed, especially in low- and middle-income countries. This study aims to assess the prevalence and factors associated with STBs among Brazilian medical students. METHODS: A survey of 1,026 Brazilian medical students gathered data on sociodemographics, STBs, depressive (PHQ-9) and anxiety symptoms (GAD-7), university stressors, learning environment, religiosity, and hazing. Prevalence and regression analyses identified associated factors, and latent class analysis (LCA) identified distinct risk groups. RESULTS: Lifetime prevalence rates were 62.7% for passive thoughts of death, 39.6% for suicidal ideation, and 12.7% for lifetime suicide attempts, with 4.4% reporting at least one attempt in the past year. Anxiety symptoms were associated with all suicidal outcomes. Depressive symptoms, university stressors, and poorer learning environment were associated with higher suicidal ideation scores, while male sex and higher intrinsic religiosity were inversely associated with depressive symptoms. In the LCA, all religiosity dimensions differed significantly across classes, with the highest levels in the Low-Risk group. Hazing victimization and non-cisgender identity were associated with suicidal behaviors. LCA identified three groups: Low-Risk (42.4%) with minimal suicidal thoughts, distress, and higher religiosity; Moderate-Risk (41.1%) with intermediate levels; High-Risk (16.5%) with severe suicidal thoughts, depression, anxiety, university stress, poor environment, and hazing. CONCLUSIONS: Based on our findings, interventions designed to address suicidality in this population may benefit from focusing on modifiable institutional factors (learning environment, university stressors, hazing) alongside individual mental health support, particularly for minority students.Rodolfo Furlan Damiano; Laura Fernandes Berto; Clarissa Garcia; Bianca Besteti Fernandes Damiano; Juliane Piasseschi de Bernardin Gonçalves; Oscarina da Silva Ezequiel; Alessandra Lamas Granero Lucchetti; Lisabeth F. DiLalla; Homero Vallada; Craig Bryan; Euripedes Constantino Miguel; Giancarlo Lucchetti

Depressive symptoms; Group (periodic table); Depression (economics); Poison control; Suicide prevention; Suicidal behavior; Clinical psychology; Psychology; Psychiatry

2026-01-01https://doi.org/10.47626/2237-6089-2025-1289Trends in Psychiatry and Psychotherapy 20261Spore morphology and sporophyte traits provide new insights into evolution in the Lejeuneaceae subtribe CyclolejeuneinaeThe subtribe Cyclolejeuneinae (Lejeuneaceae) comprises the genera Bromeliophila, Cyclolejeunea, and Prionolejeunea. Morphological, biogeographical, and ecological evidence do not align with the well-established phylogenetic pattern of the group, particularly regarding the position of Bromeliophila. A detailed investigation of sporophyte morphology is therefore essential to clarify these still unresolved relationships. In this study, we examined the sporophytic generation using morphological and palynological approaches. Specimens were obtained through field collections and herbarium loans. The sporophyte was analyzed using light and electron microscopy, while the spores were also studied using standard palynological techniques. Our results reveal that sporophyte structure is closely linked to ecological and biogeographical patterns, reflecting evolutionary adaptations within the subtribe. Variation in key characters, such as seta length, spore size, and the number of elaters and elateroids, correlates with differences in habitat and dispersal strategy. Bromeliophila, characterized by a long seta, stipitate perianth, and large spores, shows traits consistent with rheophytic and epiphyllous habits, suggesting short-distance, animal- or water-mediated dispersal. In contrast, Prionolejeunea, with numerous elaters and small to medium spores, is adapted for wind dispersal, while Cyclolejeunea maintains a broad distribution through vegetative propagation and medium spores. These findings indicate that diversification within Cyclolejeuneinae involves evolutionary trade-offs between spore morphology and dispersal strategy, reflecting adaptations to contrasting microhabitats. The observed variation in ornamentation and elater features underscores the taxonomic and ecological significance of sporophyte morphology as a key component for understanding evolutionary trajectories in Cyclolejeuneinae and, more broadly, bryophyte evolution.Ananda K. Sousa-Pereira; Fúvio R. Oliveira-da-Silva; Jainara P. Silva; Andrea P. Luizi-Ponzo; Anna L. Ilkiu-Borges

Sporophyte; Lejeuneaceae; Morphology (biology); Spore; Taxonomy (biology); Biology; Botany

2026-04-21https://doi.org/10.1080/01916122.2026.2661946Palynology 20261Comparing the effects of simultaneous execution versus isolated training on oxygen consumption during exerciseIntroduction: Strength training (ST) influences metabolic demand and training efficiency. Oxygen consumption (VO2) represents a central physiological marker linking exercise structure to energy expenditure, yet the effects of simultaneously engaging upper and lower body musculature remain underexplored. Objective: To compare the acute physiological responses to simultaneous versus isolated execution of ST exercises, focusing on VO2. Methodology: Ten recreationally trained men (25.0±3.97 years) participated in a randomized crossover design. Participants performed two protocols: simultaneous execution (SS) of incline dumbbell press and 45º leg press, and isolated execution (SI) of the same exercises in separate sets, both at 70% of one-repetition maximum. VO2 (absolute and relative), heart rate (HR), and respiratory exchange ratio (RER) were continuously measure. Linear mixed-effects models were applied to compared conditions. Results: SS elicited significantly higher VO2 than SI (VO2A: 1.58±0.06 l.min-1 vs 1.23±0.06 l.min-1; VO2R: 20.91±0.42 ml.kg-1.min-1 vs 16.38±0.55 ml.kg-1.min-1; p<0.001), with very large effect sizes. HR. was also higher in SS (p<0.001), whereas RER was significantly higher in SI (p<0.001). Discussion: The elevated VO₂ during SS likely reflects accelerated VO₂ on kinetics driven by greater concurrent muscle mass activation and reduced metabolic recovery periods, increasing systemic ATP turnover and cardiorespiratory demand. These findings highlight exercise configuration as a key modulator of physiological load beyond traditional variables such as intensity and volume. Conclusions: Simultaneous upper and lower body ST execution enhances VO2 per unit of time and represents a time-efficient strategy to increase metabolic stress, with practical implications for optimizing ST prescription in health and performance settings.José Vilaça Alves; Catia Silva; Estêvão Rios Monteiro; Jéferson Macedo Vianna; Jefferson da Silva Novaes; Nuno Domingos Garrido; Victor Reis

Cardiorespiratory fitness; Respiratory exchange ratio; Heart rate; Crossover study; Exercise prescription; VO2 max; Energy expenditure; Exercise physiology; Running economy; Time trial; Physical medicine and rehabilitation; Physical therapy; Cardiology; Medicine; Respiratory system; Consumption (sociology); Oxygen; Respiration; Respiratory quotient; Strength training; Anaerobic exercise; Exercise intensity; Lower body; Training effect; Intensity (physics)

2026-04-22https://doi.org/10.47197/retos.v80.118687Retos 20261DNA Methylation Shapes Seed‐Borne Microbiome and Proteome Responses During Early Maize‐Beneficial Bacteria InteractionsMicroorganism and plant interactions are crucial for development and environmental adaptation. Plant growth promoting bacteria enhance agricultural productivity in a sustainable manner, while epigenetic modifications such as DNA methylation regulate gene expression and adaptive responses. The objective of this study is to determine how DNA hypomethylation influences early interactions between maize (Zea mays) and the endophytic diazotrophic bacterium Herbaspirillum seropedicae, particularly regarding plant growth, metabolism, and the root microbiome. Treatment with the hypomethylating agent 5-azacytidine (5-azaC) altered maize root morphology without affecting bacterial growth. Inoculation with H. seropedicae promoted plant growth and bacterial colonisation in root mucilage, with higher accumulation in 5-azaC treated roots. Global methylation analysis showed that bacterial inoculation modulates cytosine methylation in a manner similar to 5-azaC, suggesting a role in epigenetic regulation. Gene expression analysis of DNA methylation machinery confirmed that hypomethylation drives plant-microbe interactions. Root microbiome profiling revealed that 5-azaC disrupted microbial composition, which was partially restored by bacterial inoculation. Proteomic analysis identified 1,818 proteins and highlighted significant changes in metabolic pathways, especially carbon metabolism and the citric acid cycle. These findings demonstrate that DNA hypomethylation combined with bacterial interaction profoundly affects cellular and metabolic processes and provide insights for sustainable agricultural practices through epigenetic and microbial modulation.Pedro Igor Zocateli; Geovanna Vitória Olimpio; Felipe Astolpho Almeida; Letícia Oliveira da Rocha; Diego Vinicius de Sena Martins; Sara Sangi; Fábio Lopes Olivares; Elyabe Monteiro de Matos; Juliana Siqueira; Lyderson Fácio Viccini; Roberta Pena da Paschoa; Vanildo Silveira; Clícia Grativol

DNA methylation; Epigenetics; Microbiome; Methylation; Bacteria; Gene; Gene expression; DNA; Biology; Genetics; Proteome; Regulation of gene expression; Histone; Microbiology; Microbial metabolism; Cell biology

2026-04-22https://doi.org/10.1111/pce.70552Plant Cell & Environment 20261A hipomineralização molar-incisiva influencia a higiene oral?Introdução/Justificativa: A hipomineralização molar-incisiva (HMI) é caracterizada como um defeito de qualidade do esmalte que envolve um a quatro primeiros molares permanentes e frequentemente os incisivos da mesma dentição. é um defeito qualitativo do esmalte caracterizado por aumento da porosidade, fragilidade estrutural e suscetibilidade à fratura pós-eruptiva. As características clínicas se dão por opacidades claramente demarcadas, que variam em cor do branco ao marrom. Essas alterações favorecem a retenção de biofilme dentário e podem comprometer a higiene oral, especialmente em crianças com hipersensibilidade dentinária. Além disso, limitações durante a escovação podem contribuir para maior risco de cárie e inflamação gengival. Apesar disso, a literatura apresenta resultados inconsistentes quanto à associação entre HMI e acúmulo de placa, em grande parte devido à heterogeneidade metodológica. Assim, torna-se essencial uma análise crítica das evidências disponíveis. Objetivos: Analisar criticamente se a hipomineralização molar-incisiva influencia a higiene oral, por meio da avaliação da associação entre sua presença e severidade e o acúmulo de placa bacteriana em crianças e adolescentes. Metodologia: Trata-se de uma revisão sistemática conduzida conforme as recomendações do PRISMA, com protocolo previamente registrado no PROSPERO (CRD42023470222). A pergunta de pesquisa foi estruturada pela estratégia PECOS, considerando crianças e adolescentes, exposição à hipomineralização molar-incisiva (HMI) e sua severidade, comparação com indivíduos sem HMI ou com formas mais leves, e como desfecho o acúmulo de placa bacteriana, incluindo estudos observacionais. Foram incluídos estudos observacionais originais que avaliaram clinicamente a HMI e o acúmulo de placa por métodos validados. Estudos sem grupo comparador, baseados em relatos ou avaliação de dentes extraídos foram excluídos. As buscas foram realizadas em bases eletrônicas (PubMed, Web of Science, Scopus e LILACS), além de literatura cinzenta, sem restrição de idioma ou período. A seleção dos estudos foi realizada de forma independente por dois revisores, com calibração prévia (kappa >0,80), incluindo triagem de títulos/resumos e leitura na íntegra. A extração de dados foi padronizada e também conduzida por revisores independentes. O risco de viés foi avaliado pela escala Newcastle-Ottawa modificada, considerando seleção, comparabilidade e desfecho. Resultados: A busca resultou em 474 estudos, dos quais 8 atenderam aos critérios de elegibilidade. A maioria dos estudos apresentou delineamento transversal, com amostras variando amplamente (72 a 2.107 participantes) e populações entre 3 e 16 anos, oriundas de diferentes contextos geográficos. De modo geral, observou-se tendência de maior acúmulo de placa bacteriana em indivíduos com HMI, especialmente nos casos mais severos. Estudos que avaliaram a gravidade da condição demonstraram aumento progressivo dos índices de placa entre formas leve, moderada e severa. Entretanto, os resultados não foram totalmente consistentes quando comparados indivíduos com e sem HMI. Enquanto parte dos estudos identificou maior acúmulo de biofilme e pior higiene oral em indivíduos afetados, outros não observaram diferenças significativas. Essa inconsistência pode ser atribuída, principalmente, à heterogeneidade dos métodos utilizados para avaliação da placa, incluindo diferentes índices clínicos, critérios diagnósticos e unidades de análise (boca toda versus dentes afetados). Além disso, fatores indiretos parecem desempenhar papel relevante na associação observada. Evidências apontam que a hipersensibilidade dentinária e a menor frequência de escovação em indivíduos com HMI podem contribuir para o aumento do biofilme, sugerindo que o acúmulo de placa não depende exclusivamente das alterações estruturais do esmalte, mas também de aspectos comportamentais. Quanto à qualidade metodológica, a maioria dos estudos apresentou baixo risco de viés, embora limitações relacionadas à seleção amostral tenham sido frequentes. Ainda assim, a predominância de estudos observacionais e a variabilidade metodológica reduzem a força das evidências e limitam a comparabilidade entre os achados. Conclusão: A hipomineralização molar-incisiva parece influenciar negativamente a higiene oral, especialmente em casos mais severos, embora as evidências ainda sejam inconsistentes e metodologicamente heterogêneas. No entanto, a inconsistência dos achados e a heterogeneidade metodológica entre os estudos limitam a robustez das conclusões. Do ponto de vista clínico, os resultados reforçam a necessidade de diagnóstico precoce da HMI e da implementação de estratégias individualizadas de controle de biofilme, especialmente em pacientes com maior severidade e sensibilidade dentária. Além disso, destaca-se a importância de padronização dos métodos de avaliação em estudos futuros, a fim de fortalecer o nível de evidência e subsidiar condutas clínicas mais precisas.Diêgo de Oliveira Camargos; Karina Kendelhy Santos; Vitória Pereira Alves; Lívian Maria de Oliveira Paiva; Laura Jordana Santos Lima; Júlia Valladares Badaró; Maria Eliza da Consolação Soares

Enamel paint; Dental enamel; Oral hygiene; Physics; Medicine; Dentistry; Humanities

2026-04-17https://doi.org/10.61217/rcromg.v25.731REVISTA DO CROMG 20261Diet shifts across fragmented Atlantic Forest landscapes reveal trophic plasticity in the maned wolf (Chrysocyon brachyurus)Jean Paulo da Silva; Lisandra Mendes Louzada Camilo; Marjory Cristina de Magalhães Fernandes; Lênim Faber-Lopes; Pedro Manuel Villa

Atlantic forest; Trophic level; Phenotypic plasticity; Invertebrate; Plasticity; Generalist and specialist species; Ecology; Biology; Geography

2026-04-22https://doi.org/10.1016/j.fooweb.2026.e00453Food Webs 20261Designing Interaction for Collaborative Virtual Reality: Effects of Task Structure and Tutor RepresentationRobson Santiago Viol; Saul Emanuel Delabrida Silva

TUTOR; Task (project management); Representation (politics); Virtual reality; Task analysis; Social relation; Collaborative learning; Human–computer interaction; Computer science; Computer-supported cooperative work; Cognition; Collaborative design; Interaction design; Multimedia; Collaborative software

2026-01-01https://doi.org/10.2139/ssrn.6632135SSRN Electronic Journal 20261(3151) Proposal to conserve the name Lantana undulata ( Verbenaceae ) with a conserved type(3151) Lantana undulata Schrank in Denkschr. Königl.-Baier. Bot. Ges. Regensburg 2: 56. 1822 [Angiosp.: Verben.], nom. cons. prop. Typus: Brazil, [Bahia, Ilhéus,] [1835–1837?,] [Luschnath, Martius Herb. Fl. Bras. No. 1031] (M barcode M-0111631 [image!]; isotypi: BM barcode BM000992649 [image!], BR barcodes BR0000005504619, BR0000005504633, BR0000005504947, BR0000005504985 & BR0000005504305 [left-hand specimen] [images!], G barcodes G00366440 & G00366434 [images!], K barcode K000470739 [image!], M barcode M-0111629 [image!], NY barcode 00214337 [image!], P barcode P00713631 [image!], S No. S04-2479 [image!]), typ. cons. prop. Lantana undulata Schrank (in Denkschr. Königl.-Baier. Bot. Ges. Regensburg 2: 56. 1822) was described based on material collected by Martius in Brazil and maintained in the Royal Botanic Garden in Munich in a heated greenhouse. The protologue (Schrank, l.c.) does not cite a collection or collector number, nor a specific locality. The species was characterized by having “foliis oppositis, ovato-lanceolatis, scabris, basi in petiolum cuneatis; spicis semiglobosis; bracteis tubo, pedunculis folio brevioribus; caule inermi, pubescente”. Additionally, Schrank emphasized that the inflorescences of L. undulata are capituliform, the flowers are white, with a yellow throat that fades with time, and the lower lip is very delicate and finely undulate. In a comprehensive taxonomic treatment of Verbenaceae, Schauer (in Candolle, Prodr. 11: 606. 1847) modified the original circumscription of Lantana undulata, characterizing it by having “[…] pedunculis axillaribus geminis singulisve folium subaequantibus, spicis oblongis valde elongandis et relaxandis, bracteis squarrosis membranaceis pallidis reclinatis undulatis ciliatis, infimis majoribus subrotundo-ovatis, superis oblongis basi attenuatis cuspidatis inflexis; corollae labio inferiori porrecto”. The following specimens were cited: “Salzm.! exs. n. 429, Blanchet! exs. n. 218, 631, 2365 et 3137, Luschn.! in Mart. herb. fl. bras. n. 1031! Sell.! Khotzky!” from the province of Bahia; “Guillem.! n. 600” from the province of Sebastianopolis in Ilha-Princesa; and “Cham.!” from S. Catharinae. Subsequently, Schauer (in Martius, Fl. Bras. 9: 263–264. 1851) provided a description of Lantana undulata that closely followed his 1847 treatment, accompanied by an illustration (t. 44, fig. II). This plate depicts inflorescences arranged in pairs in each leaf axil, with peduncles exceeding the subtending leaves, cylindrical spikes, and drupes with two pyrenes. Schauer (l.c. 1851) also described a new variety, L. undulata var. grandiflora, which was based on the specimen Guillemin no. 600, distinguished by its corollas with tubes more than twice as long as the subtending bract. Following the circumscription of Schauer (l.c. 1847, l.c. 1851), the name Lantana undulata became firmly associated with a plant endemic to the Brazilian Atlantic Forest, occurring mainly in Restinga (coastal vegetation) but also in seasonally deciduous forest, and characterized by having two inflorescences per leaf axil, peduncles exceeding the subtending leaves, spikes elongating up to 12 cm in fruiting, laxly arranged flowers, white corollas with a yellow throat, and vinaceous drupes with a succulent mesocarp (e.g., Silva, Redelim. Revis. Gên. Lantana Bras. [Ph.D. Thesis, Univ. São Paulo]: 132–135. 1999; Salimena in Melo & al., Fl. Faner. Ilha Cardoso, São Paulo 7: 7–26. 2000; Silva & Lima in Sitientibus, Sér. Ci. Biol. 12: 264–267. 2012; Cardoso & al. in Phytotaxa 484: 19–20. 2021a; Silva & al. in Flora & Funga do Brasil. 2026, accessed 6 Feb 2026). Because Schrank (l.c.) did not explicitly cite any original material, the specimen “Luschn. in Mart. herb. fl. bras. n. 1031”, mentioned by Schauer (l.c. 1847), came to be interpreted as the type of L. undulata. Moldenke, a major twentieth-century authority on Verbenaceae, annotated duplicates at BR and S as “cotype”, and Silva (l.c. 1999) assigned “holotype” status to a duplicate at M. However, the circumscription of Lantana undulata adopted since Schauer (l.c. 1847) is in clear conflict with the protologue, particularly regarding the length of the inflorescence peduncles and the shape of the spikes (Schrank, l.c.). Examination of the protologue and specimens deposited at M revealed original material (M-0165314) that fully agrees with the protologue and corresponds to the species concept expressed therein. This specimen exhibits semiglobose inflorescences and peduncles shorter than the leaves, as well as the remaining features of the original description, including unarmed branches, petiolate, ovate-lanceolate leaves cuneate at base, and an adaxial surface that is rough due to appressed, non-glandular trichomes, resulting in a strigose or scabrid indumentum (Schrank, l.c.). It is the only original material located; its label indicates “in Brasilia” and cultivation in the “hort. bot. Monac. | 1820”. Accordingly, this specimen would be the obligate choice of lectotype of L. undulata. In contrast, the long-standing interpretation of “Mart. herb. fl. bras. no. 1031” as the type of L. undulata likely results from an early herbarium misidentification, as these specimens bear identification labels as L. undulata in handwriting comparable to that found on M-0165314. The original material of Lantana undulata (M-0165314) does not correspond to the species concept currently applied under this name (e.g., Schauer, l.c. 1847, l.c. 1851; Silva, l.c. 1999; Salimena, l.c.; Silva & Lima, l.c.; Cardoso & al., l.c. 2021a; Silva & al., l.c. 2026). Instead, it is conspecific with Lippia aristata Schauer (l.c. 1847: 581), characterized by leaves with dentate margin, bracts with aristate or caudate apex, white corollas with yellow throat, and schizocarpic fruits. Strict application of priority would therefore require the transfer of Lantana undulata to Lippia, with Lippia aristata and its 11 heterotypic synonyms (Salimena & Cardoso in Flora & Funga do Brasil. 2026, accessed 6 Feb 2026) placed in synonymy. Furthermore, recognition of the taxon currently treated as Lantana undulata sensu Schauer (l.c. 1847) would require the creation of a new species name, potentially by elevating L. undulata var. grandiflora Schauer or L. radula subsp. glabrescens Hayek to species rank. The former was treated as a synonym of L. undulata by Silva (l.c. 1999), whereas the latter is here considered conspecific with L. undulata based on our taxonomic analyses. We argue that such a change would not represent the most appropriate solution, as it would substantially disrupt nomenclatural stability. Lantana undulata sensu Schauer (l.c. 1847, l.c. 1851) is a well-known species in Brazil. Beyond the taxonomic treatments (cited above), several studies have emphasized its medicinal value (e.g., Silva & al. in Asian J. Sci. Tech. 9: 8722–8726. 2018; Ascendino & al. in Nat. Prod. J. 12(4): 33–39. 2022) and ecological relevance (Brugnerotto & al. in Res. Soc. Developm. 10(7): 8. 2021; Santana & al. in Flora 296: 152152. 2022). It is also frequently cited in floristic inventories (e.g., Camargo & al. in Revista Ceciliana 1(2): 78. 2009; Rollo & al. in UNISANTA BioSci. 2: 57. 2013; Alves & al. in Hoehnea 42: 590. 2015; Souza & al. in Hoehnea 42: 88. 2015; Pereira & Menezes, Restingas Espírito Santo: Veg., Fl., Distr. Geogr. Esp.: 97, 290. 2023; Souza & al., Guia Pl. Dunas Restingas: 520. 2025). On the speciesLink platform alone (https://specieslink.net/search/, accessed 6 Feb 2026), more than 900 specimens are identified as L. undulata across many herbaria. Lippia aristata is a well-known species of Verbenaceae, recorded in Argentina, Bolivia, Brazil, and Paraguay. It has notable medicinal relevance and is widely cited in studies addressing chemical composition (e.g., Terblanché & Kornelius in J. Essential Oil Res. 8: 474. 1996; Silva & al. in Revista Bras. Farmacogn. 20: 843–849. 2010; Singulani & al. in J. Med. Pl. Res. 6: 4416–4422. 2012; Okhale & al. in Int. J. Pharmacogn. 3: 202. 2016; Campos & al. in Revista Bras. Farmacogn. 33: 989–1000. 2023). It also has been frequently treated in taxonomic and nomenclatural works (e.g., Silva in Taxon 50: 1117. 2001; Silva & Salimena in Darwiniana 40: 58. 2002; Salimena & Múlgura in Rodriguésia 66: 193. 2015; Cardoso & al. in Brittonia 73: 447. 2021b; Mirra & al. in Ann. Missouri Bot. Gard. 109: 440. 2024), in phylogenetic studies (e.g., Lu-Irving & al. in Amer. J. Bot. 108: 1354–1373. 2021; O'Leary & al. in Taxon 72: 572–589. 2023), and cytogenetic and palynological investigations (e.g., Campos & al. in Pl. Syst. Evol. 291: 133–140. 2011; Sousa & al. in Anais Acad. Bras. Ci. 85: 147–157. 2013). On the speciesLink platform (https://specieslink.net/search/, accessed 6 Feb 2026), more than 430 specimens are identified as L. aristata. As outlined above, the strict application of the name Lantana undulata based on Schrank's original specimen would require nomenclatural and taxonomic changes that would threaten the stability of two widely used names. Therefore, we propose the conservation of the name L. undulata with a conserved type (Art. 14.9) that corresponds to the current species concept, thereby maintaining nomenclatural stability. This will preserve the current usage of both L. undulata and Lippia aristata and prevent undesirable nomenclatural changes affecting taxonomic, biochemical, ecological, and related research, while also avoiding substantial consequences for herbarium identifications, as updating specimen determinations is typically a slow process that relies largely on in situ technical visits by specialists. The proposed conserved type (M barcode M-0111631) was likely collected by Bernhard Luschnath from Bahia (Ilhéus), Brazil between 1835 and 1837 (see Martius & al., Fl. Bras. 1: 49. 1906) and has duplicates, only one of which (BR0000005504305) bears Martius's original label, in several herbaria. These were distributed as “Martii Herbar. Florae Brasil. No. 1031”, an exsiccatum which, as mentioned above, has historically though incorrectly been considered the type of the name L. undulata. The duplicates found are as follows: BM barcode BM000992649, BR barcodes BR0000005504619, BR0000005504633, BR0000005504947, BR0000005504985 & BR0000005504305 [left-hand specimen], G barcodes G00366440 & G00366434, K barcode K000470739, M barcode M-0111629, NY barcode 00214337, P barcode P00713631, and S No. S04-2479.Pedro Henrique Cardoso; Fátima Regina Gonçalves Salimena; Jefferson Prado

Barcode; Inflorescence; Nomenclature; DNA barcoding; Lantana; Typification; Biology; Botany; Type (biology)

2026-04-01https://doi.org/10.1002/tax.70146Taxon 20261Heritage and Human Rights in Dark Times: Memories of the Forum of Organizations in Defense of the Brazilian Cultural HeritageMarcos Olender

Human rights; Cultural heritage; Cultural heritage management; Values; Industrial heritage; Political science; Sociology; Environmental ethics; Law; Media studies

2026-01-01https://doi.org/10.1007/978-3-032-16754-5_4 20261TERRITÓRIOS DE MORTE E SUBJETIVIDADES FERIDASEste artigo analisa o sofrimento psíquico da juventude negra periférica como expressão da necropolítica que organiza o território urbano brasileiro. Partindo da compreensão de que o racismo estrutural distribui desigualmente proteção e vulnerabilidade, argumenta-se que a periferia constitui espaço racializado de gestão da vida e da morte, onde jovens negros crescem sob a experiência reiterada da violência, da vigilância e do luto precoce. A partir de abordagem teórico-crítica fundamentada em autores do pensamento negro e da teoria social contemporânea, problematiza-se a tendência à psiquiatrização do sofrimento racial nos serviços de saúde mental, evidenciando como experiências estruturais de exclusão são frequentemente traduzidas em diagnósticos individualizados. Discute-se ainda os limites da universalidade abstrata no âmbito do Sistema Único de Saúde, quando a dimensão racial do sofrimento não é reconhecida como determinante central. Defende-se que a integralidade do cuidado exige deslocamento da clínica desracializada para uma prática antirracista e territorializada, capaz de nomear o racismo como operador de adoecimento. Conclui-se que, sem esse enfrentamento, a saúde mental corre o risco de administrar desigualdades que deveria transformar.Luan Vinelo Netto Rezende; Georgia C Unha de Souza Fortunato; Maria Luysa Euzebio Teodosio; Diogo Jacintho Barbosa

Social life; Context (archaeology); Racism; Perspective (graphical); Race (biology); Philosophy; Humanities; Sociology

2026-04-06https://doi.org/10.65855/aa7p8e56Revista Amefricana 20261Measurement Properties of the Modified Incremental Step Test for Assessing Exercise Capacity in Individuals With Type 2 DiabetesABSTRACT Background and Purpose A reduction in exercise capacity (EC) can be observed in individuals with type 2 diabetes (T2D) on cardiopulmonary exercise test (CPET). However, CPET is a costly maximal exercise test, limiting its routine use. This study aimed to analyze the criterion validity, convergent validity, and test‐retest reliability of the Modified Incremental Step Test (MIST), a simple, inexpensive, and portable submaximal exercise test, for assessing EC in individuals with T2D. Methods Fifty individuals with T2D (56.9 ± 11.4 years old, 50% male) attended two visits within a 2‐ to 10‐day interval. On the first visit, participants underwent a CPET. On the second visit, two repetitions of the submaximal exercise tests, the MIST and the 6‐minute walk test (6MWT), were conducted in a random order. Criterion validity was assessed using the Pearson correlation coefficient between the number of steps climbed in the best‐performed MIST and peak oxygen consumption (peak VO 2 ) from CPET. Convergent validity was evaluated by the Pearson correlation coefficient between the best MIST performance and the distance covered in the best 6MWT. Test–retest reliability was determined using the intraclass correlation coefficient (ICC) between two MIST repetitions. Results Convergent validity was supported by a moderate correlation between the number of steps climbed in the best‐performed MIST and the distance covered in the best 6MWT ( r = 0.65; p < 0.001; n = 50). In contrast, criterion validity ( r = 0.53; p = 0.023; n = 18) and test‐retest reliability (ICC [95% CI] = 0.64 [0.44–0.78]) did not meet the criteria for adequate measurement properties. Discussion This multicenter methodological study, conducted in accordance with COSMIN recommendations, contributes to the literature by evaluating the psychometric properties of the MIST for assessing EC in individuals with T2D. Although the findings do not support the MIST as a substitute for CPET, its convergent validity may support its use when 6MWT execution is not possible.Larissa Barbosa de Carvalho; Renata Cruzeiro Ribas; Maria Clara N. Alencar; Danielle Aparecida Gomes Pereira; Patrícia Fernandes Trevizan; Lílian Pinto da Silva

Intraclass correlation; Reliability (semiconductor); Type 2 diabetes; Pearson product-moment correlation coefficient; Convergent validity; Test (biology); VO2 max; Correlation; Physical therapy; Medicine; Mathematics; Correlation coefficient; Mist; Coefficient of variation; Statistics; Physical medicine and rehabilitation; Validity; Concurrent validity; Interclass correlation; Step test

2026-04-01https://doi.org/10.1002/pri.70224Physiotherapy Research International 20261Structural, electrical and surface properties of CdTe layers grown by hot wall epitaxy after CdCl2 treatmentRafael G. M. Fernandes; Sérgio Luiz de Abreu Melo; Gilberto Rodrigues-Junior; Sukarno Olavo Ferreira; V. Anjos; Maria Jose Bell; Leonarde do Nascimento Rodrigues

Van der Pauw method; Cadmium telluride photovoltaics; Annealing (glass); Thin film; Epitaxy; Chemical vapor deposition; Band gap; Electrical resistivity and conductivity; Scanning electron microscope; Solar cell; Materials science; Optoelectronics; Grain boundary; Analytical Chemistry (journal); Hall effect; Diffraction; Photoluminescence; Deposition (geology); Kelvin probe force microscope; Absorption (acoustics)

2026-01-01https://doi.org/10.2139/ssrn.6635788SSRN Electronic Journal 20261Qudit Implementation of the Rodeo Algorithm for Quantum Spectral FilteringJulio Rocha; Rodrigo Dias

Qubit; Quantum computer; Quantum algorithm; Quantum; Qutrit; Quantum phase estimation algorithm; Generalization; Gaussian; Filter (signal processing); Quadratic unconstrained binary optimization; Algorithm; Computer science; Binary number; Reduction (mathematics); Mathematics; Energy (signal processing); Computation; Ising model; Quantum state; Topology (electrical circuits)

2026-04-23https://doi.org/10.21203/rs.3.rs-9150631/v1Research Square 20261The Impact of an Engagement Solution Incorporating Antihypertensive Medications, Engagement Tools, and a Digital Application on Adherence Among Hypertensive Patients: A Real-World StudyBACKGROUND: Hypertension is the leading preventable risk factor for cardiovascular disease. The lack of treatment adherence is one of the most important challenges in managing and controlling hypertension. It is unclear whether patient-focused strategies and training for doctors are associated with better adherence and control. OBJECTIVE: This study aimed to evaluate treatment adherence among hypertensive patients by comparing a group of patients who were part of a patient support program (PSP) and were using the engagement solution (ES), i.e., antihypertensive medications, engagement tools, and the Elfie application. These patients were included in group A by trained physicians. Group B features patients who were also part of the program but were using only medications. METHODS: This observational and retrospective study analyzed data from the PSP Sempre Cuidando (Laboratórios Servier do Brasil, Rio de Janeiro, BRA) and the Elfie app (Elfie, SGP), collected from across Brazil between November 2022 and October 2023. The population included hypertensive patients aged 18 years or older with arterial hypertension and possessing a medical prescription for antihypertensives referenced in the PSP. RESULTS AND CONCLUSION: Patients were divided into two groups: 492 in group A and 984 in group B. The two groups were followed for six months. Group A demonstrated higher adherence to treatment, with an average treatment duration of 3.7 months compared to 2.7 months in group B, representing a 37% increase. Additionally, patients in group A showed statistically significant reductions in systolic blood pressure (SBP) and diastolic blood pressure (DBP) after six months versus their baseline. CONCLUSIONS: The engagement solution was associated with higher levels of adherence and improved blood pressure control among hypertensive patients.Erika M Goncalves Campana; Rodrigo J De Castro Sepetiba; Felipe R Pacheco De Souza; Gustavo Mantovani Pucci; Paulo H Gasques Trovati; Sayuri Inuzuka; Paulo C Ferraz Dias Filho; Marselha Marques Barral Montessi; Vitor B Teixeira de Holanda; Bruno A Alcova Nogueira; Lays Paulino Leonel; Renato Lima Vitorasso; Marcella Flores; Mayara Lídia da Silva

Medication adherence; Digital health; MEDLINE; mHealth; Blood pressure; Medicine; Family medicine

2026-04-23https://doi.org/10.7759/cureus.107606Cureus 20261ORAL REHABILITATION WITH IMPLANT-SUPPORTED PROSTHESIS ANCHORED IN THE ZYGOMATIC BONEIntroduction: The rehabilitation of severely atrophic maxillae represents a challenge in Implant Dentistry due to the limited bone volume available for the placement of conventional implants. In this context, zygomatic implants emerge as a therapeutic alternative, allowing anchorage in bone structures with higher density and avoiding extensive reconstructive procedures. Case report: A melanoderma patient, residing in the Zona da Mata region, underwent a surgical procedure performed under local anesthesia, following a sequential instrumentation protocol for preparation of the bone bed and placement of implants with insertion torque between 60 and 65 N·cm, indicating satisfactory primary stability. Subsequently, angled prosthetic abutments were installed to correct parallelism and enable implant-supported rehabilitation. Clinical and radiographic follow-up revealed adequate peri-implant tissue health, marginal bone stability, and functional restoration, with no signs of complications. Conclusion: Zygomatic implants can be considered a viable alternative for the rehabilitation of severely atrophic maxillae when conventional implants are unfeasible, providing structural support and functional rehabilitation.Marcelo Gabriel de Oliveira; Isis Garcia Dias Ferreira; Thiago Borges Mattos; Lídia Batista Conrado Martins; Paola Ferreira Galito; Ive Freitas Couto; Luiz Eduardo Meireles Mayrink

Prosthesis; Maxilla; Zygomatic bone; Dental prosthesis; Radiography; Implant; Medicine; Dentistry; Orthodontics; Rehabilitation; Dental alveolus

2026-04-23https://doi.org/10.66104/qbm0k167Revista Multidisciplinar do Nordeste Mineiro 20261Memórias em disputa: a produção de conhecimento sobre o passado por meio de imagens geradas por inteligência artificial generativaComo pensar as novas possibilidades de rememoração a partir de questionamentos e reflexões que buscam explorar os vieses das representações do passado feitas pela Inteligência Artificial (IA)? Esta pergunta conduz as discussões deste artigo cujo objetivo é refletir e analisar imagens que foram total ou parcialmente geradas por programas de IA Generativa e que remetem, em algum aspecto, ao passado. Para tanto, mobilizam-se pesquisas dos estudos de memória, da teoria da imagem e da IA com vistas a avançar pelas novas facetas de re(construção) do passado de forma crítica. Considera-se especialmente, as problemáticas que envolvem a opacidade de dados de treinamentos de máquinas, as disputas de poder pelas Big Techs e a perpetuação de vieses sexistas, racistas, étnicos, religiosos e históricos por parte da IA Generativa. Por meio de cinco categorias analíticas (Lembrar/Celebrar; Imaginários do passado; Ressignificar; Erros Algorítmicos; Erros históricos) em imagens), percebe-se, neste estudo inicial, que o uso da IA Generativa para representar o passado oscila entre as possibilidades imaginativas para ressignificar aquilo que não é contado pela história oficial e a chance de falhas ou reforços das desigualdades historicamente presentes na sociedade.Talita Souza Magnolo; Maurício João Vieira Filho

Theme (computing); Interpretation (philosophy); Subject (documents); Relation (database); Perspective (graphical); Order (exchange); Humanities

2026-04-23https://doi.org/10.18066/revistaunivap.v32i73.4718Revista Univap 20261Uncertainty, credibility and monetary policy in Brazil: A BVAR approach with sign restrictionsThis paper examines how uncertainty and monetary policy credibility affect economic activity and inflation expectations in Brazil. We use Bayesian Vector Autoregression (BVAR) models with sign restrictions to identify structural shocks, based on monthly data from 2003 to 2022. The results indicate that an uncertainty shock generates inflationary pressures and contractionary effects on productive activity. In contrast, an increase in the credibility indicator leads to higher output growth rates and lower inflation. Additionally, our model shows that uncertainty and credibility do not significantly affect each other, suggesting a limited interaction between macroeconomic uncertainty and the perceived credibility of the Brazilian Central Bank's monetary policy over the analyzed sample.Karina Oliveira Belarmino Almeida; Wilson Luiz Rotatori Corrêa; Luckas Sabioni Lopes

Credibility; Sign (mathematics); Monetary policy; Central bank; Economics; Monetary economics; Macroeconomics

2026-04-24https://doi.org/10.1016/j.cbrev.2026.100257Central Bank Review 20261Conductimetric and vibrational spectroscopic analyses of electrolytic solutions of interest to Mg and Mg/Li hybrid batteriesWagner A. Alves; Andrzej Eilmes; Marco A.D.A. Brito

Electrolyte; Ion; Conductivity; Spectral line; Analytical Chemistry (journal); Infrared spectroscopy; Electrical resistivity and conductivity; Infrared; Materials science; Inorganic chemistry; Chemistry; Vibration; Fast ion conductor; Mode (computer interface); Electrochemistry; Hot band

2026-01-01https://doi.org/10.2139/ssrn.6644164SSRN Electronic Journal 20261NECESSIDADES EM SAÚDE MENTAL DE COMUNIDADES TRADICIONAIS RURAISObjetivou-se conhecer as necessidades de saúde mental de comunidades indígenas e quilombolas rurais brasileiras. Trata-se de pesquisa mista que fez uso do SRQ-14, de questionário sociodemográfico e roteiro de entrevista semiestruturado. O percentual TMC encontrado foi de (33,7%), com maior incidência entre as mulheres (43,6%) e nas comunidades indígenas (37,6%). Dentre os principais fatores associados ao sofrimento emergiram as precárias condições de vida e de trabalho no campo, os padrões de gênero, as relações familiares, dificuldade de acesso às equipes e equipamentos de saúde e estressores psicossociais. A comunidade emerge, simultaneamente, como fonte de apoio primário e, contraditoriamente, como lugar de invisibilidade/individualização do sofrimento mental. Quanto aos cuidados ofertados, observa-se pouca adequação e sensibilidade às especificidades territoriais e culturais das comunidades, dando indícios do racismo institucional arraigado nas práticas profissionais e nos modos de organização dos serviços de saúde.Magda Diniz Bezerra Dimenstein; Victor Hugo Belarmino Lima; Jáder Ferreira Leite; Saulo Lüders Fernandes; Telmo Mota Ronzani; João Paulo Sales Macedo; Brisana Índio do Brasil de Macêdo Silva; Mayara Gomes Fontenele

Work (physics); Service (business); Rural area; Mental stress; Human resources; Sociology; Political science; Socioeconomics

2026-04-23https://doi.org/10.51891/rease.v12i4.25912Revista Ibero-Americana de Humanidades, Ciências e Educação 20261First-Principles Calculations of the Optoelectronic, Vibrational, and Thermoelectric Characteristics of the Novel 2D Nb 3 TeBr 7 MaterialHigh Resolution Image Download MS PowerPoint Slide Solar photovoltaic technology stands at the forefront of the renewable energy revolution, driving the quest for cleaner and more sustainable power sources. Among the countless materials under exploration are two-dimensional (2D) systems─particularly niobium-based monolayers─which have captivated researchers with their remarkable potential. In this work, we harness first-principles calculations to unveil the rich tapestry of electronic, excitonic, optical, transport, and thermoelectric properties exhibited by the Nb 3 TeBr 7 monolayer. Our computational results confirm the dynamic and mechanical stability of this intriguing material. Through detailed electronic structure analyses using PBE, PBE-SOC, and HSE06 functionals, we uncover a direct HSE06 band gap of 1.56 eV, with electronic states near the Fermi level predominantly arising from Nb atoms. The optical response of the monolayer reveals pronounced anisotropy, as captured by both the Independent Particle Approximation (IPA) and Bethe–Salpeter Equation (BSE) approaches. Estimates of power conversion efficiency (PCE) based on the Shockley–Queisser limit and the spectroscopic-limited maximum efficiency (SLME) indicate PCE values up to 30.40% at the IPA level and 27.40% at the BSE level for the monolayer. For simulated electron doping (via increased Fermi energy) at selected temperatures, the figure of merit (ZT) reaches about 0.1. Simulated hole doping (via lowered Fermi energy) yields ZT values of about 0.05. Although these ZT values are modest, their stability across a range of temperatures suggests that targeted doping with impurities might improve thermoelectric performance.Amanda C. Marques; Márcio F. Santos; Willian O. dos Santos; Elie A. Moujaes; Alexandre C. Dias; Alexandre A. Leitão

Thermoelectric effect; Work (physics); Thermoelectric materials; Seebeck coefficient; Thermoelectric cooling; Materials science; Condensed matter physics; Metallurgy

2026-04-24https://doi.org/10.1021/acsomega.6c01767ACS Omega 20261Development and measurement properties of the dysmenorrhea-related presenteeism scale for cis and transgender peopleWe developed and assessed the measurement properties of the Dysmenorrhea-related Presenteeism Scale to assess the impact of dysmenorrhea on work and/or study productivity in cis and transgender people. Experts and people with dysmenorrhea evaluated the content of the Dysmenorrhea-related Presenteeism Scale. We evaluated structural and construct validity, measurement invariance, internal consistency, test-retest reliability, measurement error, and interpretability. Three thousand three hundred and thirty-five people participated in the study. The Dysmenorrhea-related Presenteeism Scale is a 9-item, one-factor instrument. Internal consistency, measurement invariance, and test-retest reliability were sufficient. There is no systematic error. We established 38 points or more was the cutoff point to classify people as having a significant impact of dysmenorrhea on work and/or study productivity. We found that the Dysmenorrhea-related Presenteeism Scale has sufficient measurement properties and may be a useful instrument to assess the impact of dysmenorrhea on work and/or study productivity in people.Guilherme Tavares de Arruda; Barbara Inácio da Silva; Maria Eduarda Chinotti Batista da Silva; Patrícia Driusso; Mariana Arias Ávila

Presenteeism; Scale (ratio); Reliability (semiconductor); Construct (python library); Work (physics); Construct validity; Psychometrics; Psychology; Medicine; Applied psychology; Clinical psychology; Activities of daily living; Gerontology; Transgender; Productivity; Physical therapy

2026-04-24https://doi.org/10.1080/07399332.2026.2660649Health Care For Women International 20261ANÁLISE DO SISTEMA PRODUTIVO EM UMA INDÚSTRIA DE COSMÉTICOSA Onbe Indústria e Comércio de Cosméticos Ltda. é uma empresa de pequeno porte, sediada no município de Nova Serrana, Minas Gerais, que atua na fabricação de cosméticos. Atualmente, desempenha tanto na fabricação de maquiagens para sua marca própria, Sbeauty Make Up, quanto na terceirização da produção para outras marcas do setor. O estudo deste artigo caracteriza-se como uma pesquisa qualitativa e descritiva, desenvolvida por meio de um estudo de caso de um trabalho de campo. A análise baseou-se em observação direta dos processos produtivos e no acompanhamento das atividades realizadas na empresa, permitindo a compreensão do funcionamento do sistema produtivo. É notório que as medidas de desempenho são fundamentais para que a Onbe mantenha sua competitividade, eficiência operacional e satisfação dos clientes. Entre os principais objetivos de desempenho adotados pela empresa destacam-se custo, rapidez, confiabilidade, qualidade e flexibilidade. A empresa ajusta sua produção de acordo com pedidos em carteira, para clientes estratégicos, garantindo maior flexibilidade sem comprometer o fluxo produtivo. Na gestão industrial, o estudo enfatiza que, a adoção de práticas adequadas de planejamento, controle e melhoria contínua, contribui diretamente tanto para o desempenho operacional quanto para a competitividade das empresas do setor de cosméticos.Gabriela Guerra de Alvarenga Andrade; Dayanne Caldeira Martins; Juliane Souza Costa; Marielza Corrêa dos Reis; Karina Cristiane Domingues Pereira; Lucas Aparecido Gontijo Costa

Work (physics); Quality (philosophy); Public accounting; Humanities; Political science; Physics; Business

2026-01-01https://doi.org/10.37885/260120990Editora Científica Digital eBooks 20261Evolução funcional 18 meses após rizotomia dorsal seletiva em uma criança com paralisia cerebral bilateral da Zona da Mata: relato de casoINTRODUCTION: Selective Dorsal Rhizotomy (SDR) is a neurosurgical intervention used to reduce spasticity in children with cerebral palsy (CP). Despite advances, SDR is still not widely disseminated, and the scarcity of reports limits the understanding of its functional impacts. OBJECTIVE: To describe the functional changes in a child with bilateral spastic CP, diplegic type, after SDR combined with physiotherapy. MATERIALS AND METHODS: Case report with longitudinal follow-up for 18 months of a 3-year-8-month-old male child, classified by the Gross Motor Function Classification System (GMFCS) as level III, who underwent SDR and intensive postoperative rehabilitation. Spasticity was assessed using the Modified Ashworth Scale, and functioning using the Gross Motor Function Measure (GMFM-66), preoperatively and every three months after surgery. GMFM-66 scores were analyzed using GMAE-3 software, which allowed for the estimation of Expected Natural Evolution (ENE) as a parameter to interpret gains over time. RESULTS: After surgery, a reduction in spasticity in the lower limbs was observed. In all postoperative assessments, variations in GMFM-66 scores were greater than the ENE, with a significant increase at three months (p<0.05), a period marked by the acquisition of motor skills previously limited by spasticity. CONCLUSION: SDR combined with physiotherapy and family involvement showed a reduction in spasticity and a significant increase in functioning and motor capacity. The child's active participation and parental involvement were key factors for the success of the treatment.Isabela de Pádua Ruiz; Vanessa Aparecida Dias Chaves; Leonardo Raphael Santos Rodrigues; Júlia de Souza Castilho; Rayla Amaral Lemos; Paula Silva de Carvalho Chagas

Spasticity; Cerebral palsy; Rhizotomy; Gross Motor Function Classification System; Gross motor skill; Spastic; Spastic quadriplegia; Spastic cerebral palsy; Medicine; Physical medicine and rehabilitation; Modified Ashworth scale; Dorsum; Motor skill; Spastic diplegia; Physical therapy; Spastic hemiplegia; Motor function; Motor control; Activities of daily living; Hypertonia

2026-04-24https://doi.org/10.17267/2238-2704rpf.2026.e6494Revista Pesquisa em Fisioterapia 20261Uncovering ciliate diversity in rumen microbiomes through computational species delimitation approachesAbstract Herbivorous mammals host a complex microbiological community composed of archaea, bacteria, fungi, and ciliate protists. Metabarcoding sequencing approaches are among the main tools used to investigate these microbiomes. Despite their contribution to our understanding of local biodiversity, detailed taxonomic analyses are hindered by gaps in knowledge regarding ciliate diversity and fundamental taxonomic inferences. Short-reads alignment software from next-generation sequencing (NGS), along with computational species delimitation methods, offer promising tools for analyzing these data, enhancing accuracy and revealing previously undocumented lineages and diversity patterns within microbiomes. We propose a new workflow that integrates short-reads alignment with computational species delimitation, using different algorithms to analyze microbiomes from bovines and camelids. Our results showed that amplicon sequence variants (ASVs) from bovine and camelid microbiomes clustered within known families of endosymbiotic protists. At the level of taxonomic signatures, the application of different delimitation methods yielded contrasting numbers of Evolutionarily Significant Units (ESUs) across the microbiomes analyzed. In addition, the approaches were able to recover taxonomic signatures at the genus level and identify taxonomic correspondences with known species. They also demonstrated greater taxonomic resolution when applied to the bovine microbiome and revealed hidden diversity within the camelid microbiome. This work is pioneering in presenting a methodological framework for processing amplicon data generated by NGS platforms, enabling a more refined taxonomic analysis of the structure of ciliated protist communities.M. B. Lima; J. D. Medeiros Júnior; R. J. P. Dias; M. F. Rossi

Microbiome; Taxonomic rank; Amplicon; Biological classification; Ciliate; Candidatus; Vertebrate; Protist; Biology; Evolutionary biology; Metagenomics; DNA sequencing; Ecology; Operational taxonomic unit; Biodiversity; Host (biology); Computational biology; Taxonomy (biology)

2026-04-25https://doi.org/10.1007/s13199-026-01141-xSymbiosis 20261In-series multimode interference sensors and Fabry-Perot interferometers for enhanced wavelength shift resolving capabilities• Refractive index sensor obtained by integrating a SMS structure with a FPI in an in-series configuration. • The FPI modulates the SMS signature with interferometric fringes, reducing the width of the spectral features monitored. • Achieved a sensitivity-to-FWHM ratio displaying a 33-fold improvement over the SMS structure alone. • Two SMS-FPI configurations: one with an tunable air–gap FPI and another with a polymer film drop-casted onto a fiber tip. We report on the development of a refractive index sensor obtained by using a singlemode-multimode-singlemode (SMS) structure and a Fabry-Perot interferometer (FPI) set into an in-series configuration. Due to the self-imaging phenomenon, the SMS structure, formed by splicing a no-core fiber between two singlemode fibers, provides a broad spectral peak whose central wavelength position is sensitive to variations in the refractive index of the medium surrounding the fiber. In turn, thanks to the in-series SMS-FPI configuration, the sensor’s reflection spectrum exhibits the SMS spectral signature modulated by FPI fringes. This readily allows for reducing the width of the spectral features monitored during the sensing measurements, thus enhancing the capabilities of adequately resolving the corresponding spectral shifts. The FPIs reported in this investigation have been fabricated by using two different methods, namely by forming an air–gap FPI between the cleaved ends of two singlemode optical fibers, and by casting a polymeric film onto a connectorized fiber end tip. In the first configuration, the distance between the two cleaved fiber ends could be varied to tune the FPI’s free spectral range, hence allowing for tailoring the widths of the spectral oscillations to be monitored during the sensing measurements. Alternatively, the second configuration, while avoiding the use of motorized translation stages, provides a more versatile option for applications. Thus, we understand that our work expands the application of multimode interference and FPIs in sensing scenarios, providing new opportunities for probing physical and chemical parameters by exploring their combined response.João G.M. de Carvalho; Luiz D.C. Silva; Flavio A.M. Marques; Alexandre A. C. Cotta; Jefferson Esquina Tsuchida; Julio C. Ugucioni; S E B Silva; Leomar S. Marques; Diego C. Fuzatto; Alexandre Bessa dos Santos; Cristiano M. B. Cordeiro; Limin Xiao; Jonas H. Osório

Interferometry; Refractive index; Multi-mode optical fiber; Wavelength; Optical fiber; Interference (communication); Graded-index fiber; Fiber optic sensor; Refractive index profile; Optics; Materials science; Reflection (computer programming); Spectral width; Optoelectronics; Normalized frequency (unit); Astronomical interferometer; Photonic-crystal fiber; Fiber; Amplified spontaneous emission; Single-mode optical fiber

2026-04-25https://doi.org/10.1016/j.yofte.2026.104659Optical Fiber Technology 20261Role of autonomic receptors in ethyl ferulate-induced cardiovascular effects in normotensive and hypertensive female ratsAbstract Aims Ethyl ferulate (EF) may offer novel benefits in hypertension. We investigated the contribution of autonomic receptors to EF-induced effects in female Wistar and SHR. Methods Anesthetized females received EF intravenously at 7.5, 15, or 30 mg/kg. Autonomic involvement was evaluated using pretreatment with atropine, atenolol, or hexamethonium. MAP and HR were continuously monitored. Results EF induced rapid and pronounced reductions in MAP and HR in both strains. In Wistar rats, muscarinic and nicotinic blockade significantly attenuated these responses. In SHR, atropine abolished bradycardia and partially mitigated hypotension, whereas β1-adrenergic and nitric oxide synthase inhibition had minimal impact. Conclusion EF acutely lowers MAP and HR, with muscarinic and nicotinic receptors driving the effects in normotensive females, and muscarinic pathways partially mediating responses in hypertensive females. These results position EF as a compelling candidate for antihypertensive therapy and underscore the critical need to study cardiovascular interventions in female hypertension models.Francisca Valdirene de S. Nunes; Samuel S. P. de Araujo; Juliana A. da Silva; José Assunção; Ariell A. de Oliveira; Carlos E. R. Dourado; Vandercley de O. Damasceno; Aldeidia P. Oliveira; Maria do Carmo C. Martins; Mayara C. de Morais; Damião P. de Sousa; Thyago M. de Queiroz; Renato N. Soriano; Luiz G.S. Branco; Helio C. Salgado; João Paulo J. Sabino

Blood pressure; Receptor; Autonomic nervous system; Hemodynamics; Heart rate; Sympathetic nervous system; Medicine; Internal medicine; Endocrinology

2026-04-25https://doi.org/10.1007/s00424-026-03170-3Pflügers Archiv - European Journal of Physiology 20261Decolonial Conservation and Political Ethnobiology as a Pathway to Socio-Environmental Justice in the Global SouthBiodiversity conservation remains largely shaped by technocratic and colonial paradigms that marginalize the political agency of Indigenous peoples, traditional communities, and racialized populations. In response, we propose Political Ethnobiology as a critical approach for a truly decolonial conservation. Grounded in Political Ecology, decolonial thought, feminism, and Ethnobiology, we argue that socio-environmental conflicts are not externalities, but arenas of negotiation regarding power, knowledge, and nature. We examine how hegemonic models reproduce epistemic violence and exclusion through the enclosure of territories and disregard for local autonomy, despite legal instruments for benefit-sharing. This scenario reflects a structural incompatibility with plural ontologies. By centering local experiences and those of racialized women, we highlight the disputes within conservation governance. Based on this, we propose four pillars for a People-Based Decolonial Conservation: (1) epistemic justice and co-authorship of knowledge, (2) people-based conservation and pluriverses, (3) ethics of Buen Vivir and socioecological reciprocity, and (4) institutional transformation and epistemic justice. We advocate for a paradigmatic shift that goes beyond symbolic inclusion, advancing toward the redistribution of power, the recognition of "pluriverses," and the construction of practices grounded in social justice, ecological reciprocity, and political accountability.Rodrigo Felipe Rodrigues do Carmo; Arthur André de Barros Rodrigues; Jeferson Matheus Gomes de Moura; Clau Aguiar Silva; Cínthia Diniz de Oliveira; Paula Thayanne da Mata; Julio Avanzo Neto; Manoela Olegário da Costa; Gustavo Taboada Soldati

Politics; Indigenous; Ethnobiology; Economic Justice; Agency (philosophy); Environmental justice; Colonialism; Hegemony; Ethnography; Political ecology; Sociology; Environmental ethics; Political philosophy; Transformative learning; Alterity; Political anthropology; Negotiation; Racialization; Anthropocentrism; Epistemology; Political science

2026-04-25https://doi.org/10.15451/ec2026-04-15-10-1-17Ethnobiology and Conservation 20261Ornamental Potential of the UFJF Botanical Garden: Analysis of Local Flora for Use in Territorial JewelryLia Paletta Benatti; Gabriella Silveira Murta Pinheiro; André Carvalho Mol Silva

Flora (microbiology); Ornamental plant; Assemblage (archaeology); Biodiversity; Geography

2026-01-01https://doi.org/10.1007/978-3-032-07626-7_11Environmental footprints and eco-design of products and processes 20261Polynomial model with Asymmetric Curvature Induced by Excess for mixture design: optimization of green anthocyanin extraction from Cenchrus purpureus using a standardless chromatographic responseCanonical Scheffé mixture models are widely used for binary systems, but their inherent assumption of symmetric component behavior restricts their ability to describe processes in which mixture components fulfill distinct physicochemical roles. This limitation is especially relevant for solvent-based extraction systems involving water and ethanol. In this study, the extraction of anthocyanins from leaves of Cenchrus purpureus . using water:ethanol mixtures were investigated, and an alternative modeling framework, named Asymmetric Curvature Induced by Excess (ACIE), was proposed to overcome this conceptual constraint. Experimental and simulated approach were evaluated in this work. Extractions were carried out by static maceration at room temperature using only water and ethanol, in accordance with Green Chemistry principles. The extracts were analyzed by HPLC-DAD, and a semi-quantitative approach was adopted in which the response variable was defined as the sum of the chromatographic peak areas of the two most reproducible anthocyanin signals. Canonical Scheffé linear and quadratic models were unable to adequately represent the system, exhibiting lack of fit and limited predictive capability. In contrast, ACIE, by incorporating asymmetric curvatures for modeling the excess of each component, achieved superior statistical performance and a more realistic representation of the response surface. The model predicted an optimal extraction region between 82 and 92% ethanol, consistent with the distinct roles of ethanol in promoting cell wall disruption and water in anthocyanin solubilization. These results show that ACIE effectively addresses a fundamental limitation of Scheffé-based models relative to asymmetries in binary mixtures and provides a flexible, chemically interpretable framework that may be applicable to other systems characterized by asymmetric component functionality.Luiz Henrique Cantarino Adriano; Patrícia Abranches Geraldo; Cecília Pinto Nogueira; Juarez Campolina Machado; Marcone Augusto Leal de Oliveira

Extraction (chemistry); Anthocyanin; Polynomial; Curvature; Response surface methodology; Chromatography; Chemistry; Mathematics; Cenchrus ciliaris

2026-04-26https://doi.org/10.1016/j.chemolab.2026.105731Chemometrics and Intelligent Laboratory Systems 20261Perfil dos doadores de órgãos da Zona da Mata MineiraIntrodução: Os transplantes de órgãos ao longo do tempo se tornaram uma terapia bem-sucedida para tratar doenças em estágio avançado. A demanda por transplantes cresce substancialmente, porém apesar dos avanços, a diferença entre demanda e disponibilidade de órgãos continua a crescer e a insuficiência de doadores para transplante representa um problema de saúde pública. Objetivo: Caracterizar o perfil dos doadores efetivos de órgãos da Zona da Mata Mineira. Material e Métodos: Trata-se de um estudo descritivo, com abordagem quantitativa, realizado a partir dos protocolos de morte encefálica de potenciais doadores da Organização de Procura de Órgãos da Zona da Mata Mineira, no período de janeiro de 2014 a dezembro de 2023. A coleta dos dados ocorreu de junho a dezembro de 2024. Resultados: Compuseram a amostra da pesquisa 583 notificações, das quais, 39,8% tiveram o desfecho da doação, enquanto 60,2% não realizaram a doação de órgãos. O perfil encontrado de doadores efetivos de órgãos foi majoritariamente indivíduos do sexo masculino, brancos e com faixa etária entre 51 e 60 anos, apresentando comorbidades prévias, como Hipertensão Arterial Sistêmica (HAS), Diabetes Mellitus (DM), etilismo e tabagismo. Conclusão: Salienta-se a importância de conhecer o perfil dos doadores de órgãos, visando o desenvolvimento de estratégias para detecção precoce dos possíveis doadores e para fundamentação de protocolos de abordagem familiar e otimização do tempo entre abertura e fechamento do protocolo de morte encefálica. Enfatiza-se ainda que, no Brasil, o número de doações ainda não atende à demanda de pacientes que aguardam por um transplante na lista de espera.Tatiane Ribeiro da Silva; Ronaldo Rocha Bastos; Patrícia Rodrigues Braz; Graziela Lonardoni de Paula

MEDLINE; Electrocution; Hospital discharge; Medicine; Humanities; Gynecology

2026-04-01https://doaj.org/article/8770e758df244f1997ce03d2bbf07140DOAJ (DOAJ: Directory of Open Access Journals) 20261Passados presentes Usos da história oral e iniciativas de história pública em uma abordagem histórica sobre patrimônios e memórias afro-indígenas em Minas GeraisRESUMO O artigo apresenta uma reflexão sobre autoridade compartilhada, autoria e construção do conhecimento histórico no âmbito do projeto Passados Presentes: patrimônios e memórias negras (africanas e afro-indígenas) em Minas Gerais. A metodologia da pesquisa coletiva se organizou a partir de uma escuta atenta e horizontal da história e da memória dos detentores de patrimônios negros mineiros como quilombos, reinados/congados, jongos e folias de reis, com o objetivo de estabelecer diálogos epistêmicos entre saberes social e culturalmente localizados, ou seja, entre os pesquisadores das universidades participantes e os mestres/detentores dos patrimônios/memórias em foco. O presente artigo toma por base quatro entrevistas de história oral, com roteiros genealógicos e de história de vida, com os 4 principais consultores/detentores participantes do projeto. Essas entrevistas enfatizaram, em especial, as relações de cada um dos entrevistados com a territorialidade negra das cidades em que vivem e a historicidade da escravidão e das interações afro-indígenas em suas narrativas. O artigo mobiliza também a oralidade dos pontos de caboclo e de pretos velhos nas umbandas, fenômeno religioso que perpassa todas as trajetórias e grupos estudados, como chave de leitura das narrativas trabalhadas. A conclusão busca demonstrar a importância do diálogo epistêmico como ferramenta de renovação do conhecimento historiográfico.Hebe Mattos; Josemeire Alves Pereira; RHONNEL AMÉRICO

Context (archaeology); Exploratory research; Indigenous; Qualitative research; Ethnography; Oral history; Latin Americans; Ethnic group; Participant observation; Sociology; Geography; Social science; Political science; Humanities

2026-01-01https://doi.org/10.1590/0104-87752026v42e26016Varia Historia 20261uso de referências literárias clássicas nos Loci Praecipui Theologici (1559) de Filipe MelanchthonPersonagens literários desempenham um papel significativo na teologia de Filipe Melanchthon. Por um lado, eles expressam erudição e refinamento afim a uma concepção humanista pelo teólogo. Por outro, são apresentados como exemplos humanos de vícios e de virtudes, ou simplesmente como representações da condição humana à luz da perspectiva religiosa protestante. Este texto, após expor elementos centrais do uso que Melanchthon faz de figuras clássicas, demonstra, com breves descrições, como as elabora na última edição da sua principal obra dogmática, os Loci. O objetivo é mostrar que a sua perspectiva humanista tem uma apreciação positiva de autores clássicos, muito diferente do literalismo bíblico ou das perspectivas fundamentalistas.Eduardo Gross

Principal (computer security); Interpretation (philosophy); Philosophy; Epistemology; Molecular biology

2026-04-25https://doi.org/10.55702/3m.v30i60.69384Terceira Margem 20261How Brazil’s Scientific Development Fund affects researcher productivityAbstract University research is crucial for technological progress and economic growth, especially in developing countries. In Brazil, the sectoral funds linked to the National Fund for Scientific and Technological Development (FNDCT) were established in 1999 and have provided strategic support for science and technology; however, they have faced challenges following budget cuts after 2011. This study assesses the impact of public funding through the FNDCT on the scientific productivity of Brazilian researchers, as measured by the number of articles published. Using a differences-in-differences model covering the period from 1995 to 2016, with funding beginning in 2001, the results show that public funding has a positive and significant impact on scientific output. However, volatility and the reduction of financial resources undermine the potential of this support, highlighting the need for more stable and predictable public policies to ensure the continuity and effectiveness of investments in science and technology in Brazil.Lizandra Duarte da Silva; Eduardo GONÇALVES; Márcia Siqueira Rapini; André Suriane da Silva

Productivity; Public funding; Volatility (finance); Public fund; Public support; Technology development; Technological change; Public sector; Business; Economics; Economic growth; Finance

2026-03-16https://doi.org/10.1093/scipol/scag029Science and Public Policy 20261EPI-DRC Brasil: triagem da doença renal crônica com teste rápido de creatinina durante o Dia Mundial do RimResumo Introdução: A Doença Renal Crônica (DRC) é um problema de saúde pública, com prevalência estimada em 10% no Brasil, possivelmente subestimada por desigualdades regionais e limitações diagnósticas. O estudo EPI-DRC Brasil teve como objetivo estimar a prevalência de taxa de filtração glomerular estimada (TFGe) <60 mL/min/1,73m2 em adultos com fatores de risco, por meio de triagem com teste rápido de creatinina (POCTcr) durante o Dia Mundial do Rim/2025, além de avaliar variações regionais e preditores associados. Métodos: Estudo transversal multicêntrico, realizado em 20 regionais da Sociedade Brasileira de Nefrologia, incluindo indivíduos ≥18 anos com pelo menos um fator de risco para DRC (idade >60 anos, hipertensão (HA), diabetes (DM), doença cardiovascular, obesidade, uso crônico de anti-inflamatórios não esteroidais, histórico de injúria renal aguda, litíase renal bilateral ou história familiar de DRC). A função renal foi avaliada pelo teste rápido de creatinina (NovaMaxPro®-TFGe CKD-EPI 2021). Considerou-se TFGe reduzida quando <60 mL/min/1,73m2. Resultados: Analisamos 8.374 participantes (66,9% mulheres; mediana 58 anos; IMC 28,3kg/m2; 46,2% pardos). A frequência de TFGe reduzida foi 40,2% (n = 3.370), 36% estágios G3b–G5. Apenas 35,2% conheciam fatores de risco para DRC. Houve diferenças regionais significativas (de 27,9% [Bahia] a 55,2% [Paraná]; p < 0,001). Preditores independentes incluíram: idade (OR = 1,032; IC95%: 1,028–1,035), HA (OR = 1,27; IC95%: 1,15–1,40) e, como fator protetor, etnia indígena (OR = 0,40; IC95%: 0,20–0,89), p < 0,05. O risco aumentou 23% a cada fator de risco adicional. Conclusão: Observou-se elevada frequência de TFGe reduzida e baixo conhecimento sobre fatores de risco para DRC. O estudo demonstra a viabilidade do POCTcr em estratégias de rastreamento e reforça a necessidade de políticas públicas para ampliar o diagnóstico precoce e fortalecer a atenção primária.Viviane Calice-Silva; Patrícia Abreu; Maria Eliete Pinheiro; Ana Katarina de Cerqueira Delgado Lopes; Karla Cristina Petruccelli Israel; Ana Wanda Barreto Marinho; Ana Flavia Moura; Felipe Costa Neves; Cláudia Maria Costa de Oliveira; Silvana Daher Costa; Luiz Roberto de Sousa Ulisses; Fábio Humberto Ribeiro Paes Ferraz; Ramiele Aparecida Cruz Souza; Rachel Gatti Armani; Ciro Bruno Silveira Costa; Marcelo Garcia Tavares; Dyego José de Araújo Brito; Érika Cristina Ribeiro de Lima Carneiro; Luiz Gonzaga Filho; Jenaine Oliveira Paixão; Helady Sanders‐Pinheiro; Luís Cláudio Santos Pinto; Lucas Acatauassu Nunes; Pablo Rodrigues Costa Alves; Amanda Maíra Damasceno Silva; Rene Scalet Dos Santos Neto; Suzana Ricardo Greffin; Gisele Vajgel; J. Andrade; GINIVALDO VICTOR RIBEIRO DO NASCIMENTO; Igor Denizarde Bacelar Marques; Maria Izabel de Holanda; Pedro Tulio Monteiro de Castro Abreu Rocha; Kalyanne Cabral de Paula do O; Lelyanne Rodrigues Pereira Torauato; Cristina Karohl; Juliana Alves Manhães de Andrade; Ariane Karen de Sousa; Denise Rodrigues Simão; Ana Carolina Nakamura Tome; Daniela [UNESP] Ponce; Fernanda Salomão Gorayeb-Polacchini; Maria Almerinda Vieira Fernandes Ribeiro Alves; Rubens Escobar Pires Lodi; Cinthia Montenegro; José A. Moura-Neto

Risk factor; Diabetes mellitus; Kidney disease; Disease; Medicine; Gynecology

2026-01-01https://doi.org/10.1590/2175-8239-jbn-2025-0298ptBrazilian Journal of Nephrology 20261Anticryptococcal Evaluation of the Allylimine 3H2: Modulation of Virulence Traits and Synergistic Action with Amphotericin BHigh Resolution Image Download MS PowerPoint Slide The development of new antifungal scaffolds is critical for expanding therapeutic options against cryptococcosis. Here, we evaluated the allylimine 3H2 as a potential lead compound against Cryptococcus gattii . The allylimine 3H2 exhibited consistent in vitro activity with a geometric mean MIC of 7.5 μg mL –1 across 12 strains and showed a synergistic interaction with amphotericin B, with FICI values reaching 0.5. The compound impaired major virulence determinants, reducing capsule size, melanin synthesis, and laccase activity while altering the negative surface charge. In a murine model, 3H2 potentiated amphotericin B therapy, extending survival to over 100 days and markedly lowering fungal burden in both lungs and brain. Docking simulations supported interactions of 3H2 with targets involved in melanin biosynthesis and cell wall-associated processes. These findings highlight 3H2 as a promising scaffold for antifungal drug discovery and support its further optimization as a candidate for combination therapy against cryptococcosis.Thaís Furtado Ferreira Magalhães; Heber Victor Tolomeu; Luíza Braga Ferreira dos Santos; Cleide Viviane Buzanello; Danielle Letícia Silva; Gabriella Freitas Ferreira; Julliana Ribeiro Alves dos Santos; Marliete Carvalho da Costa; Vanessa Da Silva Dutra de Carvalho; Daniel Assis Santos; Cleiton Moreira da Silva; Maria Aparecida de Resende-Stoianoff; Ângelo de Fátima

Amphotericin B; Virulence; Antifungal; In vitro; Melanin; Cryptococcus neoformans; Drug; In vivo; Cell culture; Microbiology; Biology; Chemistry; Cryptococcus; Cytotoxicity; Docking (animal); Monoclonal antibody; Antibiotics; Pharmacology; Strain (injury); Mixed lymphocyte reaction; Combination therapy; Enzyme; Biological activity; Mechanism of action; Cell survival

2026-04-27https://doi.org/10.1021/acsomega.6c01027ACS Omega 20261encantamento pelo Outro na poética e no pensamento de Alberto PucheuO propósito deste artigo é pensar, na obra poética e ensaística de Alberto Pucheu, gestos de encantamento pelo Outro. Tal encantamento não será traduzido como sacralização do Outro, mas compreendido justamente em diálogo com o ethos desencantado de certas poéticas modernas ocupadas em dessacralizar a vida, o artista e a arte.André Monteiro Guimarães Dias Pires

Measure (data warehouse); Context (archaeology); Work (physics); Order (exchange); Humanities; Philosophy

2026-04-25https://doi.org/10.55702/3m.v30i60.69945Terceira Margem 20261Past Presents Uses of Oral History and Public History Initiatives in a Historical Approach to Afro-Indigenous Heritage and Memories in Minas GeraisABSTRACT The article presents a reflection on shared authority, authorship, and the construction of historical knowledge within the scope of the project Passados Presentes: Patrimônios e Memórias Negras (Africanas e Afro-Indígenas) em Minas Gerais (Past Presents: Black Heritage and Memories (African and Afro-Indigenous) in Minas Gerais). The methodology of the collective research was organized based on attentive and horizontal listening to the history and memories of the holders of Black heritage in Minas Gerais, such as quilombos, reinados/congados, jongos, and folias de reis, to establish epistemic dialogues between socially and culturally localized knowledge, that is, between researchers from participating universities and the masters/holders of the heritage/memories focused. This article is based on four oral history interviews, conducted with genealogical and life history scripts, and featuring the four leading consultants/holders participating in the project. These interviews emphasised the relationships of each of the interviewees with the black territoriality of the cities in which they live and the historicity of slavery and Afro-indigenous interactions in their narratives. It also draws on the oral tradition of “caboclo and pretos velhos” (elderly black men) in “umbandas”, a religious phenomenon that permeates all the trajectories and groups studied, as a key to understanding the narratives examined. The conclusion seeks to demonstrate the importance of epistemic dialogue as a tool for renewing historiographical knowledge.Hebe Mattos; Josemeire Alves Pereira; RHONNEL AMÉRICO

Oral history; Historicity (philosophy); Public history; Historiography; Narrative; Active listening; Historical thinking; Black history; Historical method; Sociology; Anthropology; History; Phenomenon; Comparative historical research; Scope (computer science); Aesthetics

2026-01-01https://doi.org/10.1590/010487752026v42e26017Varia Historia 20261Influência do Expoente da Lei de Potência na Geração de Árvores Arteriais com um Algoritmo Baseado no Método CCOÁrvores arteriais são redes de vasos que não só transportam, mas também distribuem nutrientes e oxigênio pelo corpo humano, desempenhando um papel essencial no sistema circulatório. O estudo dessas estruturas é fundamental para entender a hemodinâmica de componentes relevantes do sistema cardiovascular. Entre as abordagens para a construção de modelos de árvores arteriais coronárias, destaca-se o método CCO (Constrained Constructive Optimization), que possibilita a elaboração de modelos fundamentados em uma função custo particular e em uma lei de potência que regula os diâmetros dos vasos nas bifurcações durante o crescimento do modelo. Este artigo investiga um novo algoritmo derivado do CCO, capaz de elaborar modelos de árvores arteriais coronárias, incorporando uma lei de potência que considera a quantidade de bifurcações proximais de cada vaso. Os modelos 2D preliminares gerados por este método conseguem reproduzir de maneira satisfatória dados morfométricos de árvores arteriais coronárias reais.Lucas Diego Mota Meneses; Bernardo Martins Rocha; Rafael Alves Bonfim de Queiroz

Context (archaeology); Constructive; Order (exchange); Reflection (computer programming); Argument (complex analysis); Humanities; Philosophy; Computer science

2026-04-27https://doi.org/10.63595/vetor.v36i1.18334VETOR - Revista de Ciências Exatas e Engenharias 20261Permanent Reservoir Monitoring (PRM) and Distributed Acoustic Sensing (DAS) as Advanced Technologies for Maximizing the Acquisition of Acoustic Environmental InformationThis chapter explores new methods to enhance the use of existing data from established technologies, namely Permanent Reservoir Monitoring (PRM) and Distributed Acoustic Sensing (DAS), to maximize the acquisition of acoustic environmental information. Cetaceans, particularly baleen whales, rely heavily on sound and are vulnerable to human-made underwater noise, which can mask their vital low-frequency vocalizations. High operational costs and logistical challenges in deep, offshore environments often constrain Traditional Passive Acoustic Monitoring. This work presents the repurposing of PRM data from the Jubarte Field, and the implementation of a DAS field measurement campaign using an existing Petrobras submarine fiber-optic cable, both in the Campos Basin, Brazil. The PRM dataset, sampled at 500 Hz, confirmed the seasonal occurrence of multiple mysticete species, including humpback ( Megaptera novaeangliae ), sei ( Balaenoptera borealis ), and fin ( Balaenoptera physalus ) whales. Preliminary DAS laboratory and field tests established a robust technical basis, with the system demonstrating sensitivity to low-frequency biological sounds, thereby enabling the detection of periodic calls strongly resembling fin whale vocalizations (40–120 Hz). The results demonstrate the potential of integrating geophysical and bioacoustic data, leveraging existing infrastructure for sustainable, continuous, large-scale oceanic monitoring. This strategic approach significantly expands acoustic knowledge of baleen whales in the South Atlantic, supporting conservation and impact mitigation efforts.Artur Andriolo; Eduardo Hilzendeger Marcon; Franciele R. de Castro; Gabrieli M. Rodrigues; Gustavo A. Miranda; Yasmin Viana; Patricia M. Golodne; Roque A. C. Poeys; Alexandre A. C. Silva; Thiago O. S. Amorim; Divna Djokic; José Luis A. Pizzorno

Baleen; Humpback whale; Underwater; Acoustic sensor; Repurposing; Field (mathematics); Whale; Bioacoustics; Computer science; Environmental science; Marine engineering; Marine mammal; Remote sensing; Underwater acoustics; Submarine; Submarine pipeline; Environmental monitoring; Underwater acoustic communication; Data acquisition

2026-01-01https://doi.org/10.1007/978-3-031-94229-7_225-1 20261Hermitian Symmetric Orthogonal Chirp-Division MultiplexingThis letter revisits orthogonal chirp-division multiplexing (OCDM) for baseband data communication systems, usually employed in wireline communication. We demonstrate that an existing formulation for generating real-valued chirp sequences shows limited temporal spreading. In the sequel, we introduce the hermitian-symmetric (HS)-OCDM technique, which correctly spreads chirp sequences, thereby improving performance. Numerical simulations show that the proposal offers enhanced robustness against cyclic prefix length violations and synchronization impairments granted to the spreading of the chirp signals in the whole symbol duration.Gustavo M. Campos; Túlio F. Moreira; Mateus de L. Filomeno; Ândrei Camponogara; Andrea M. Tonello; Moisés V. Ribeiro

Hermitian matrix; Multiplexing; Topology (electrical circuits); Hermitian function; Signal processing; Orthogonality; Symmetric matrix; Mathematics; Computer science; Combinatorics; Physics; Discrete mathematics

2026-01-01https://doi.org/10.1109/lcomm.2026.3687387IEEE Communications Letters 20261Guia ReINVenTA para Audiodescrição FílmicaMaucha Gamonal; Flávia Mayer; Frederico Guedes; Igor Antônio Lourenço da Silva; Mariane de Carvalho Pinto; Adriana Silvina Pagano; Tiago Torrent

2026-04-24https://doi.org/10.5281/zenodo.19862441Zenodo (CERN European Organization for Nuclear Research)

20261Search for signatures of electroweakinos with photons, jets, and large missing transverse momentum in $$ \sqrt{s}=13 $$ TeV pp collisions with the ATLAS detectorA bstract A search for final states characterised by at least one isolated high transverse-momentum photon, jets and large missing transverse momentum is presented. Such a final state might occur in gauge-mediated supersymmetric models where a pair of binos and higgsinos mix to form neutralinos, one of which decays into a photon plus a gravitino while the other decays into a Higgs boson, a Z boson or a photon, plus a gravitino. The search is performed using the full Run-2 data sample of 140 fb − 1 of $$ \sqrt{s}=13 $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msqrt> <mml:mi>s</mml:mi> </mml:msqrt> <mml:mo>=</mml:mo> <mml:mn>13</mml:mn> </mml:math> TeV proton-proton collisions collected by the ATLAS detector at the Large Hadron Collider. No significant excess of events is observed above the Standard Model prediction and model-dependent exclusion limits at the 95% confidence level are set. These limits are interpreted in terms of the masses of gauginos, which are excluded up to 1.2 TeV depending on their branching ratios, and on their branching ratios as a function of their mass.G. Aad; E. Aakvaag; B. Abbott; S. Abdelhameed; K. Abeling; N. J. Abicht; S. H. Abidi; M. Aboelela; A. Aboulhorma; H Abramowicz; Y. Abulaiti; B. S. Acharya; A. Ackermann; C. Adam Bourdarios; L. Adamczyk; S. V. Addepalli; M. J. Addison; J. Adelman; A. Adiguzel; T. Adye; A. A. Affolder; Y. Afik; M. N. Agaras; A. Aggarwal; C. Agheorghiesei; F. Ahmadov; S. Ahuja; X. Ai; G. Aielli; A. Aikot; M. Ait Tamlihat; B. Aitbenchikh; M. Akbiyik; T. P. A. Åkesson; A. V. Akimov; D. Akiyama; N. N. Akolkar; S. Aktas; G. L. Alberghi; J. Albert; U. Alberti; P. Albicocco; G. L. Albouy; S. Alderweireldt; Z. L. Alegria; M. Aleksa; C. Alexa; I. N. Aleksandrov; T. Alexopoulos; F. Alfonsi; M. Algren; M. Alhroob; B. Ali; H. M. J. Ali; S. Ali; S. W. Alibocus; M. Aliev; G. Alimonti; W. Alkakhi; C. Allaire; B. M. M. Allbrooke; J. S. Allen; J. F. Allen; P. P. Allport; A ALOISIO; F. Alonso; C. Alpigiani; Z. M. K. Alsolami; A. Alvarez Fernandez; M. Alves Cardoso; M ALVIGGI; M. Aly; A. Ambler; C. Amelung; M. Amerl; C. G. Ames; T. Amezza; D. Amidei; B. Amini; K. Amirie; A. Amirkhanov; S. P. Amor Dos Santos; K. R. Amos; D. Amperiadou; S. An; C. Anastopoulos; T. Andeen; J. K. Anders; A. C. Anderson; A. Andreazza; S. Angelidakis; A. Angerami; A. V. Anisenkov; A. Annovi; C. Antel; E. Antipov; M. Antonelli; F. Anulli; M. Aoki; T. Aoki

Large Hadron Collider; Gravitino; Atlas detector; Higgs boson; Atlas (anatomy); Branching fraction; Hadron; Boson; Supersymmetry; Physics; Particle physics; Nuclear physics; Detector; ATLAS experiment; Standard Model (mathematical formulation); Gluino; Minimal Supersymmetric Standard Model; Lightest Supersymmetric Particle; Physics beyond the Standard Model; CMB cold spot; Phenomenology (philosophy)

2026-04-17https://doi.org/10.1007/jhep04(2026)150Journal of High Energy Physics 20261Pensamento crítico na formação docente: contribuições do PIBID Química na perspectiva de egressos em exercício na Educação BásicaAnalisa-se de que modo o PIBID Química da Universidade do Estado do Pará contribuiu para a formação docente e para o desempenho profissional atual de egressos que atuam na Educação Básica, tendo o pensamento crítico como referência teórica. Para tanto, desenvolveu-se um estudo qualitativo, de natureza descritiva, com 16 egressos que atuam na Educação Básica. Suas narrativas, obtidas por meio de questionário on-line, foram organizadas em um corpus e submetidas a análises lexicais no software IRaMuTeQ, utilizando-se nuvem de palavras, análise fatorial de correspondência e análise de similitude. Nos relatos, a tomada de decisões fundamentadas aparece quando os egressos justificam escolhas metodológicas e descrevem ajustes nas intervenções em função das respostas das turmas. A sensibilidade ao contexto manifesta-se na preocupação em conhecer a realidade da escola e adaptar atividades às condições reais da sala de aula. A reflexão e autoavaliação da prática emergem em passagens em que os participantes revisam planejamentos, reconhecem limites da própria atuação e identificam aprendizagens vinculadas à participação no PIBID. Persistem, entretanto, alguns limites, como a dificuldade de relacionar de maneira mais clara as decisões pedagógicas às evidências de aprendizagem dos estudantes e de explicitar, nos relatos, características próprias do conhecimento químico e de seu ensino. A pesquisa contribui para o avanço do estado da arte na Educação em Química ao evidenciar as potencialidades e limites do PIBID, no desenvolvimento do pensamento crítico durante a formação inicial de professores de Química.Ronilson Freitas de Souza; Andréia Francisco Afonso

Night work; Humanities; Philosophy

2026-04-15https://doi.org/10.36661/2595-4520.2026v9n2.15499Revista Insignare Scientia - RIS 20261ACESSIBILIDADE DIGITAL NA ESCOLA: PRÁTICAS INCLUSIVAS PARA TODOS OS ALUNOSeste artigo discute a acessibilidade digital na escola como dimensão constitutiva do direito à educação inclusiva. Parte-se da compreensão de que a presença de dispositivos, plataformas e ambientes virtuais não assegura, por si só, participação pedagógica, permanência e aprendizagem. O objetivo é analisar fundamentos conceituais, normativos e pedagógicos da acessibilidade digital e apresentar práticas inclusivas aplicáveis ao cotidiano escolar, com atenção aos diferentes perfis de estudantes, inclusive aqueles com deficiência, transtornos do neurodesenvolvimento, dificuldades de aprendizagem, barreiras linguísticas e limitações temporárias de acesso. Metodologicamente, trata-se de estudo qualitativo, de natureza bibliográfica e documental, com base em legislação brasileira, documentos de organismos internacionais e literatura científica sobre educação inclusiva, desenho universal para a aprendizagem, tecnologia assistiva e acessibilidade web. A análise demonstra que a acessibilidade digital exige uma abordagem sistêmica: depende de infraestrutura, escolha adequada de plataformas, formação docente, produção de materiais acessíveis, avaliação flexível e participação da comunidade escolar. Também se evidencia que práticas simples, como legenda em vídeos, descrição de imagens, contraste adequado, navegação por teclado, múltiplas formas de representação do conteúdo e diversificação das formas de resposta, produzem efeitos concretos sobre o engajamento e a autonomia dos estudantes. Sustenta-se que a escola inclusiva precisa deslocar o foco da adaptação tardia para o planejamento antecipado, inspirado no desenho universal para a aprendizagem. A partir das evidências discutidas, a acessibilidade digital pode ser compreendida não como recurso periférico, mas como critério de qualidade pedagógica, justiça curricular e democratização do conhecimento.Edgleisom Marculino da Silva; Cristina Hill Fávero; Gustavo Perroni Gomes da Silva; Gabriela Esther Nascimento dos Santos; Wanderlene Mara da Silva Gomes; Wilton Silva Abreu; Cybelle Aline Oliveira Milhomem; Ruan Rick dos Santos Costa; Bárbara Maria Silva dos Santos; Marcos Antônio da Silva

Digital inclusion; Autonomy; Comprehension; Meaning (existential); Psychology; Philosophy; Computer science; Sociology; Humanities; Epistemology; Linguistics

2026-04-28https://doi.org/10.70773/revistatopicos/777262243Revista Tópicos. 20261Kinetic Overview of Polynuclear Platinum(II) Complexes in Heparan Sulfate Substitution: Mimetic Model Analysis and Mechanistic PerspectivesHigh Resolution Image Download MS PowerPoint Slide Polynuclear platinum(II) complexes (PPCs) represent a promising class of anticancer agents, offering enhanced efficacy and reduced toxicity compared with traditional mononuclear platinum drugs. Their interactions extend beyond DNA to include noncovalent and covalent binding with biologically relevant anions, such as sulfates and carboxylates, in glycosaminoglycans (GAGs) like heparan sulfate (HS) and chondroitin sulfate. This study investigates the chloride substitution mechanisms in PPCs using a Cl–PtN3 model, evaluating both aquation-driven and direct substitution pathways with GAG mimetic models of iduronic acid, IdoA(2S), and glucose, GlcNS(6S). A computational benchmarking analysis identified the double-hybrid DFT functional B2PLYP as the most accurate method, displaying an absolute deviation of only 1.05 kcal mol –1 from the DLPNO–CCSD(T) reference. Free energy profiles revealed similar energy transition-state species ranging from ca. 26 to 30 kcal mol –1, while direct substitutions exhibit lower activation barriers but are thermodynamically less favorable. The inclusion of explicit water molecules in the solvation layer was also addressed and significantly drove the results toward experimental data, with a better description of the active complex. These findings, added to our microkinetic analysis, provide insight into PPC ligand-exchange mechanisms, contributing to the rational design of next-generation platinum-based anticancer therapeutics.Frederico Henrique do C. R. Ferreira; Nicholas P. Farrell; Luiz Antônio S. Costa

Heparan sulfate; Non-covalent interactions; Sulfation; Molecule; Density functional theory; Solvation; Small molecule; Rational design; Chemistry; Computational chemistry; Stereochemistry; Combinatorial chemistry; Covalent bond

2026-04-28https://doi.org/10.1021/acsomega.5c13472ACS Omega 20261Guia ReINVenTA para Audiodescrição FílmicaMaucha Gamonal; Flávia Mayer; Frederico Guedes; Igor Antônio Lourenço da Silva; Mariane de Carvalho Pinto; Adriana Silvina Pagano; Tiago Torrent

2026-04-24https://doi.org/10.5281/zenodo.19862442Zenodo (CERN European Organization for Nuclear Research)

20261Observation of structures in the <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"> <mml:mi>J</mml:mi> <mml:mo>/</mml:mo> <mml:mi>ψ</mml:mi> <mml:mo>+</mml:mo> <mml:mi>ψ</mml:mi> <mml:mo stretchy="false">(</mml:mo> <mml:mn>2</mml:mn> <mml:mi>S</mml:mi> <mml:mo stretchy="false">)</mml:mo> </mml:math> mass spectrum with the ATLAS detectorA search for resonant structures in the <a:math xmlns:a="http://www.w3.org/1998/Math/MathML" display="inline"> <a:mrow> <a:mi>J</a:mi> <a:mo>/</a:mo> <a:mi>ψ</a:mi> <a:mo>+</a:mo> <a:mi>ψ</a:mi> <a:mo stretchy="false">(</a:mo> <a:mn>2</a:mn> <a:mi mathvariant="normal">S</a:mi> <a:mo stretchy="false">)</a:mo> </a:mrow> </a:math> mass spectrum is performed using proton-proton collision data at <f:math xmlns:f="http://www.w3.org/1998/Math/MathML" display="inline"> <f:msqrt> <f:mi>s</f:mi> </f:msqrt> <f:mo>=</f:mo> <f:mn>13</f:mn> <f:mtext> </f:mtext> <f:mtext> </f:mtext> <f:mi>TeV</f:mi> </f:math> , corresponding to an integrated luminosity of <h:math xmlns:h="http://www.w3.org/1998/Math/MathML" display="inline"> <h:mn>140</h:mn> <h:mtext> </h:mtext> <h:mtext> </h:mtext> <h:msup> <h:mi>fb</h:mi> <h:mrow> <h:mo>−</h:mo> <h:mn>1</h:mn> </h:mrow> </h:msup> </h:math> , recorded by the ATLAS experiment at the LHC. The decay channels of <j:math xmlns:j="http://www.w3.org/1998/Math/MathML" display="inline"> <j:mi>J</j:mi> <j:mo>/</j:mo> <j:mi>ψ</j:mi> <j:mo>+</j:mo> <j:mi>ψ</j:mi> <j:mrow> <j:mo stretchy="false">(</j:mo> <j:mn>2</j:mn> <j:mi mathvariant="normal">S</j:mi> <j:mo stretchy="false">)</j:mo> </j:mrow> <j:mo stretchy="false">→</j:mo> <j:mn>4</j:mn> <j:mi>μ</j:mi> </j:math> and <p:math xmlns:p="http://www.w3.org/1998/Math/MathML" display="inline"> <p:mi>J</p:mi> <p:mo>/</p:mo> <p:mi>ψ</p:mi> <p:mo>+</p:mo> <p:mi>ψ</p:mi> <p:mrow> <p:mo stretchy="false">(</p:mo> <p:mn>2</p:mn> <p:mi mathvariant="normal">S</p:mi> <p:mo stretchy="false">)</p:mo> </p:mrow> <p:mo stretchy="false">→</p:mo> <p:mn>4</p:mn> <p:mi>μ</p:mi> <p:mo>+</p:mo> <p:mn>2</p:mn> <p:mi>π</p:mi> </p:math> are analyzed. An excess near 6.9 GeV is observed in both channels with a combined significance of <v:math xmlns:v="http://www.w3.org/1998/Math/MathML" display="inline"> <v:mrow> <v:mn>8.9</v:mn> <v:mi>σ</v:mi> </v:mrow> </v:math> . No significant signal is observed near 7.2 GeV, and an upper limit on its yield relative to <x:math xmlns:x="http://www.w3.org/1998/Math/MathML" display="inline"> <x:mi>X</x:mi> <x:mo stretchy="false">(</x:mo> <x:mn>6900</x:mn> <x:mo stretchy="false">)</x:mo> </x:math> is provided. A simultaneous fit with the di- <bb:math xmlns:bb="http://www.w3.org/1998/Math/MathML" display="inline"> <bb:mi>J</bb:mi> <bb:mo>/</bb:mo> <bb:mi>ψ</bb:mi> </bb:math> channel is carried out under assumptions regarding the resonance interferences, yielding a ratio of the partial decay widths between the <db:math xmlns:db="http://www.w3.org/1998/Math/MathML" display="inline"> <db:mi>J</db:mi> <db:mo>/</db:mo> <db:mi>ψ</db:mi> <db:mo>+</db:mo> <db:mi>ψ</db:mi> <db:mrow> <db:mo stretchy="false">(</db:mo> <db:mn>2</db:mn> <db:mi mathvariant="normal">S</db:mi> <db:mo stretchy="false">)</db:mo> </db:mrow> </db:math> and di- <ib:math xmlns:ib="http://www.w3.org/1998/Math/MathML" display="inline"> <ib:mi>J</ib:mi> <ib:mo>/</ib:mo> <ib:mi>ψ</ib:mi> </ib:math> channels of <kb:math xmlns:kb="http://www.w3.org/1998/Math/MathML" display="inline"> <kb:mn>1.08</kb:mn> <kb:mo>±</kb:mo> <kb:mn>0.2</kb:mn> <kb:msubsup> <kb:mn>0</kb:mn> <kb:mrow> <kb:mo>−</kb:mo> <kb:mn>0.17</kb:mn> </kb:mrow> <kb:mrow> <kb:mo>+</kb:mo> <kb:mn>0.40</kb:mn> </kb:mrow> </kb:msubsup> </kb:math> for the resonance near 6.9 GeV.Anonymous; E. Aakvaag; B. Abbott; S. Abdelhameed; K. Abeling; N. J. Abicht; S. H. Abidi; M. Aboelela; A. Aboulhorma; H. Abramowicz; Y. Abulaiti; B. S. Acharya; A. Ackermann; C. Adam Bourdarios; L. Adamczyk; S. V. Addepalli; M. J. Addison; J. Adelman; A. Adiguzel; T. Adye; A. A. Affolder; Y. Afik; M. N. Agaras; A. Aggarwal; C. Agheorghiesei; F. Ahmadov; S. Ahuja; S. Ahuja; X. Ai; G. Aielli; A. Aikot; M. Ait Tamlihat; B. Aitbenchikh; M. Akbiyik; T. P. A. Åkesson; A. V. Akimov; D. Akiyama; N. N. Akolkar; S. Aktas; G. L. Alberghi; J. Albert; U. Alberti; P. Albicocco; G. L. Albouy; S. Alderweireldt; Z. L. Alegria; M. Aleksa; I. N. Aleksandrov; C. Alexa; T. Alexopoulos; F. Alfonsi; M. Algren; M. Alhroob; B. Ali; H. M. J. Ali; S. Ali; S. W. Alibocus; M. Aliev; G. Alimonti; W. Alkakhi; C. Allaire; B. M. M. Allbrooke; D. R. Allen; J. S. Allen; J. F. Allen; P. P. Allport; A. Aloisio; F. Alonso; C. Alpigiani; Z. M. K. Alsolami; A. Alvarez Fernandez; M. Alves Cardoso; M. G. Alviggi; M. Aly; Y. Amaral Coutinho; A. Ambler; C. Amelung; M. Amerl; C. G. Ames; T. Amezza; D. Amidei; B. Amini; K. Amirie; A. Amirkhanov; S. P. Amor Dos Santos; K. R. Amos; D. Amperiadou; S. An; C. Anastopoulos; T. Andeen; J. K. Anders; A. C. Anderson; A. Andreazza; S. Angelidakis; A. Angerami; A. V. Anisenkov; A. Annovi; C. Antel; E. Antipov; M. Antonelli

Detector; Atlas (anatomy); Atlas detector; Noise (video); Staring; Physics; Optics; Remote sensing

2026-04-28https://doi.org/10.1103/zhkx-k9zlPhysical review. D/Physical review. D. 20261Double-edged sword: flavivirus NS1 enhances human plasmin-mediated fibrinolysis while being targeted for cleavage and inactivationmosquitoes. Symptomatic individuals may develop a haemorrhagic fever leading to plasma leakage, hypovolaemic shock and death. A key player in viral pathogenesis is the non-structural protein 1 (NS1), which is secreted by infected cells and disrupts platelet and endothelial barrier function, contributing to plasma extravasation. Importantly, dengue patients present abnormal haemostasis, with concomitant activation of both coagulation and fibrinolytic systems correlating with disease severity. However, a direct role played by NS1 in fibrinolysis has never been shown. Here, we investigated the interaction between NS1 and plasminogen, the precursor of the fibrinolytic enzyme plasmin, aiming to characterize its implications in clot turnover during infection. We showed that binding of plasminogen to NS1 is dependent on lysine-binding sites in plasminogen, implicating NS1 as a plasmin substrate. We also demonstrated that NS1 is cleaved by plasmin, which, in turn, blocks its effect on endothelial glycocalyx layer disruption and endothelial hyperpermeability. Using euglobulin clot lysis assays, we showed that DENV NS1 enhances fibrin clot lysis and that this effect is conserved for other flaviviruses, including Zika and West Nile viruses. Altogether, we identified a novel mechanism by which NS1 might contribute to bleeding disorders, highlighting the relevance of the plasminogen/plasmin system for DENV pathogenesis in humans.Lucas Mendes-Monteiro; Pedro Henrique Carneiro; Jonas N. Conde; Joice Lima Menezes; M de O Souza; Pedro Freitas de Carvalho; Eugênio D. Hottz; Eva Harris; Diego Allonso; Ronaldo Mohana-Borges

Fibrinolysis; Pathogenesis; Coagulation; Fibrin; Glycocalyx; Plasmin; Dengue fever; Platelet; Inflammation; Chemistry; Immunology; Endothelium; Hemostasis; Cell biology; Protein C; Endothelial stem cell; Disseminated intravascular coagulation; Plasminogen activator; Endothelial activation

2026-04-29https://doi.org/10.1099/jgv.0.002253Journal of General Virology 20261ADAMANTANE AMINE DERIVATIVES AS MULTITARGET COMPOUNDS FOR ALZHEIMER'S DISEASE: IN SILICO, IN VITRO, AND IN VIVO STUDIESAdamantoid amino compounds were investigated for their effects on two primary targets in Alzheimer’s disease, acetylcholinesterase (AChE) and NMDA receptor. The compounds were synthesized in two steps: the hydroxyl group of adamantane-1-methanol was substituted with iodine, followed by replacement with an amine. Compounds were tested as acetylcholinesterase inhibitors (iAChE - Ellman test) and antioxidant activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH). Toxicity was evaluated employing the Artemia salina and Allium cepa assays. Cytotoxicity was determined in glial cells (U87) and mouse fibroblasts (L929) by the MTT test. Compounds exhibited high AChE inhibition capacity (78-97%) and low antioxidant activity (less than 35%). The samples had different cytotoxic performances. Compounds 1, 2, 3, and 5, which had a terminal NH2 group, were more cytotoxic than the samples with this group replaced, reinforcing its importance for biological activity. This pattern was also observed in the iAChE test and confirmed by molecular docking studies. Compound 3 was the most promising, exhibiting higher enzyme inhibition (iAChE, 97%) and no toxic effects in the Artemia salina assay. The C elegans trial confirmed the ability of compound 3 to act on different therapeutic targets, modulating the cholinergic and glutamatergic activity in the pharyngeal beat test and locomotor parameters of the nematode.Adriana García; Mauro V. de Almeida; Hélio F. Dos Santos; José M. S. de Campos; Heveline Silva; A S DA SILVA; Felix A. A. Soares; Nádia R. B. Raposo

Acetylcholinesterase; Cytotoxicity; In vivo; Artemia salina; Aché; Antioxidant; MTT assay; Enzyme; In vitro; Chemistry; Biochemistry; Stereochemistry; Biological activity; Amine gas treating; Lead compound; Toxicity; Structure–activity relationship; Docking (animal); Cytotoxic T cell; Pharmacology; Adamantane; Residue (chemistry); Viability assay; Bioassay

2026-04-30https://doi.org/10.5281/zenodo.19910419Zenodo (CERN European Organization for Nuclear Research) 20261ADAMANTANE AMINE DERIVATIVES AS MULTITARGET COMPOUNDS FOR ALZHEIMER'S DISEASE: IN SILICO, IN VITRO, AND IN VIVO STUDIESAdamantoid amino compounds were investigated for their effects on two primary targets in Alzheimer’s disease, acetylcholinesterase (AChE) and NMDA receptor. The compounds were synthesized in two steps: the hydroxyl group of adamantane-1-methanol was substituted with iodine, followed by replacement with an amine. Compounds were tested as acetylcholinesterase inhibitors (iAChE - Ellman test) and antioxidant activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH). Toxicity was evaluated employing the Artemia salina and Allium cepa assays. Cytotoxicity was determined in glial cells (U87) and mouse fibroblasts (L929) by the MTT test. Compounds exhibited high AChE inhibition capacity (78-97%) and low antioxidant activity (less than 35%). The samples had different cytotoxic performances. Compounds 1, 2, 3, and 5, which had a terminal NH2 group, were more cytotoxic than the samples with this group replaced, reinforcing its importance for biological activity. This pattern was also observed in the iAChE test and confirmed by molecular docking studies. Compound 3 was the most promising, exhibiting higher enzyme inhibition (iAChE, 97%) and no toxic effects in the Artemia salina assay. The C elegans trial confirmed the ability of compound 3 to act on different therapeutic targets, modulating the cholinergic and glutamatergic activity in the pharyngeal beat test and locomotor parameters of the nematode.Adriana García; Mauro V. de Almeida; Hélio F. Dos Santos; José M. S. de Campos; Heveline Silva; A S DA SILVA; Felix A. A. Soares; Nádia R. B. Raposo

2026-04-30https://doi.org/10.5281/zenodo.19910418Zenodo (CERN European Organization for Nuclear Research) 20261Upgrade of the trigger and data acquisition system for continuous imaging and multi-camera operation in CYGNOAbstract The CYGNO experiment employs an optical readout to image particle interactions in a gaseous Time Projection Chamber (TPC), combining cameras and photomultiplier tubes (PMTs) to achieve high spatial resolution and timing information. This approach enables detailed track reconstruction but poses significant challenges for data acquisition, particularly in view of the next experimental phase, CYGNO-04, which will operate multiple cameras simultaneously. In this paper, we present an upgrade of the CYGNO Trigger and Data Acquisition (T-DAQ) system, developed starting from the LIME configuration and validated on the MANGO prototype. The upgrade introduces a continuous imaging acquisition mode, substantially reducing the camera dead time, together with an extended trigger time-tagging scheme that provides a robust global time reference for PMT signals. A synchronous multi-camera DAQ architecture is also implemented and tested, enabling coordinated operation of multiple optical sensors without a master camera. The performance of the upgraded system is validated through dedicated tests, demonstrating stable continuous acquisition, reliable time-tagging, and consistent synchronization across multiple cameras. These results establish a solid and scalable foundation for the CYGNO-04 DAQ and represent a key step toward efficient data acquisition in future large-scale optical TPC detectors.F. D. Amaro; R. Antonietti; E. Baracchini; L. Benussi; C. Capoccia; M. Caponero; L. G. M. de Carvalho; G. Cavoto; I. A. Costa; A. Croce; M. D'Astolfo; G. D'Imperio; G. Dho; E. Di Marco; J. M. F. dos Santos; D. Fiorina; F. Iacoangeli; Z. Islam; E. Kemp; H. P. Lima Jr; G. Maccarrone; R. D. P. Mano; D. J. G. Marques; G. Mazzitelli; P. Meloni; A. Messina; V. Monno; C. M. B. Monteiro; R. A. Nobrega; G. M. Oppedisano; I. F. Pains; E. Paoletti; F. Petrucci; S. Piacentini; D. Pierluigi; D. Pinci; F. Renga; A. Russo; G. Saviano; P. A. O. C. Silva; N. J. Spooner; R. Tesauro; S. Tomassini; D. Tozzi

2026-04-01https://doi.org/10.1088/1748-0221/21/04/t04004Journal of Instrumentation 20261Impact of tofacitinib on growth in patients with juvenile idiopathic arthritisHermine I Brunner; Mittermayer Santiago; Beth Gottlieb; Sheila K Oliveira; Pooja Patel; Viviane Angelina de Souza; Kristin Houghton; C A A da Silva; Maria Teresa Terreri; Rubén Cuttica; Muammer Hakan Poyrazoğlu; Halley Wasserman; Michelle Saul; Catherine Soderstrom; Anne Diehl; Ivana Vranic; Arne Yndestad; Mahta Mortezavi; Daniel J. Lovell; Alberto Martini; Nicolino Ruperto

Tofacitinib; Juvenile; Post-hoc analysis; Janus kinase inhibitor; Arthritis; Population; Medicine; Internal medicine; Endocrinology; Growth hormone; Janus kinase

2026-04-01https://doi.org/10.1016/j.ard.2026.03.030Annals of the Rheumatic Diseases 20261Effects of acute, subacute, and chronic exercise on plasma s-Klotho levels: a systematic review and meta-analysisExercise exerts beneficial effects on multiple physiological systems, influencing biomarkers associated with aging processes and chronic diseases. This systematic review and meta-analysis aimed to evaluate the acute, subacute, and chronic effects of exercise on s-Klotho levels in healthy individuals and patients with chronic diseases. A comprehensive search was conducted in electronic databases. Included studies were randomized and non-randomized studies assessing the effects of aerobic, resistance, or combined exercise on s-Klotho levels. Interventions were classified as acute (single session), subacute (< 12 weeks), or chronic (≥ 12 weeks). Risk of bias was assessed using RoB 2 and ROBINS-I tools, and quality of evidence was evaluated with the GRADE framework. Forty-one studies were included in the qualitative synthesis, and 30 in the meta-analysis, comprising 2,765 participants (18-85 years). Twenty-five involved healthy individuals, while 21 included patients with chronic diseases. Acute and subacute aerobic exercise increased s-Klotho levels in healthy individuals (SMD 0.69; 95%CI 0.41-0.97) and diseased populations (SMD 0.62; 95%CI 0.11-1.12). Chronic exercise (12-36 weeks) showed significant increases in healthy (SMD 0.57; 95%CI 0.33-0.82) and diseased populations (SMD 1.51; 95%CI 0.87-2.16). Resistance exercise thrice weekly demonstrated the highest effect (SMD 1.60; 95%CI 0.81-2.38). Most studies had high risk of bias, with quality of evidence ranging from very low to moderate. Exercise significantly increases s-Klotho levels, with acute and subacute aerobic sessions benefiting healthy and diseased populations, while chronic resistance exercise elicited greater responses in diseased populations. Despite promising findings, low methodological quality suggests cautious interpretation.Túlio Medina Dutra de Oliveira; Diogo Carvalho Felício; Taynara da Silva Ribeiro; José Elias Filho; Francisco J. Amaro‐Gahete; Giovani Bernardo Costa; Jorge Willian Leandro Nascimento; Maycon Moura Reboredo; Carla Malaguti

Aerobic exercise; Resistance training; Quality of life (healthcare); Psychological intervention; Randomized controlled trial; Physical exercise; Physical activity; Chronic disease; Medicine; Physical therapy; Internal medicine; Chronic fatigue syndrome; Exercise physiology; Meta-analysis

2026-05-02https://doi.org/10.1007/s13105-026-01182-2Journal of Physiology and Biochemistry 20261A multimodal explainable ai framework to assist in the differential diagnosis of head and neck reactive follicular hyperplasia and follicular lymphoma: an international multicentre studyThe differential diagnosis between reactive follicular hyperplasia (RFH) and follicular lymphoma (FL) in head and neck tissues represents a diagnostic challenge, particularly given the rarity of extranodal FL at these anatomical sites. We developed and evaluated an explainable multimodal artificial intelligence framework to assist in this differential diagnosis. This international multicentre study assembled 108 cases (54 RFH, 54 FL) from 10 centres across 4 continents, representing one of the largest collections of head and neck follicular lesions. We developed a multimodal framework integrating convolutional neural networks (CNNs: AlexNet, VGG16, ResNet18), vision transformers (CellViT + +), graph neural networks (Cell-GNN for spatial analysis), and gradient-boosted decision trees (XGBoost) with morphometric features. Explainability was achieved through Grad-CAM visualisation and SHAP analysis. The best-performing model (CellViT + +) achieved 95.7% accuracy on the internal test set. External validation demonstrated accuracy of 80.5% (ResNet18, Cohort 1) and 69.0% (VGG16-Seg, Cohort 2), with performance variation reflecting the challenge of generalisation across centres. Explainability analysis revealed that the multimodal framework integrated morphometric features (nuclear area, eccentricity) with epidemiological context (patient age, consistent with known FL demographics). Cell-GNN spatial analysis identified significant architectural reorganisation in FL, quantified by Hedges' g = -6.65, representing the loss of normal follicular polarity. This study demonstrates the feasibility of a multimodal explainable AI framework for assisting in the differential diagnosis of rare head and neck follicular lesions. The integration of morphological, spatial, and clinical features provides a foundation for future collaborative validation studies and potential diagnostic support in specialised pathology settings.Lucas Lacerda de Souza; Zhiyang Chen; Cinthia Veronica Bardález López de Cáceres; Nathalia Gomes Rodrigues; Hélder Antônio Rebelo Pontes; Ciro Dantas Soares; Fábio Luiz Coracin; Igor Kimura; Sheila Aparecida Coelho Siqueira; Fernanda Viviane Mariano; Talita de Carvalho Kimura; João Felipe Leite Bonfitto; Leandro Luiz Lopes de Freitas; Sibele Nascimento de Aquino; Paul Hankinson; Hanya Mahmood; Hannah Walsh; Itzia Araceli Torres Torres; Adalberto Mosqueda-Taylor; Pedro Bandeira Aleixo; M L Martins; Carolina Louzada Menna-Barreto; Ahmed Hagag; Thaís Cerqueira Reis Nakamura; Giovanna Calabrese dos Santos; Matheus Cardoso Moraes; Marcio Ajudarte Lopes; Alan Roger Santos-Silva; Felipe Paiva Fonseca; Syed Ali Khurram; Pablo Agustin Vargas

Differential diagnosis; Follicular lymphoma; Context (archaeology); Multimodal therapy; Cohort; Follicular hyperplasia; Medicine; Pathology; Follicular phase; Radiology; Head and neck; Convolutional neural network; Artificial intelligence; Medical physics

2026-05-02https://doi.org/10.1007/s00428-026-04527-wArchiv für Pathologische Anatomie und Physiologie und für Klinische Medicin 20261Eficácia da Artrocentese no Tratamento das Disfunções Temporomandibulares: Uma Revisão de LiteraturaA artrocentese é um procedimento minimamente invasivo, realizado na articulação temporomandibular com risco reduzido de complicações. Pode ser realizada sob anestesia geral, local ou sedação, sendo considerada de primeira escolha para pacientes que não tiveram melhora com o tratamento conservador. Dentre suas indicações de tratamento, estão o deslocamento do disco articular, trismo de origem articular, dor articular. Tradicionalmente, a artrocentese utiliza soluções irrigadoras para remover detritos e promover ação terapêutica no interior da ATM. A pesquisa escolhida para o trabalho, foi de caráter bibliográfico, trata-se de uma revisão de literatura voltada à construção do objeto de estudo por meio da análise de obras pertinentes ao tema. Durante a pesquisa e construção deste trabalho, foi possível identificar informações significativas que indicam melhorias em pacientes com Disfunção Temporomandibular (DTM) por meio da prática da artrocentese. Palavras-Chave: Artrocentese; Síndrome da Disfunção da Articulação Temporomandibular; Articulação Temporomandibular.Rafael Ricardo Renha Weiss Senise; Rafael Meira Pimentel; Gustavo Correa Machado; Thaís Teixeira de Abreu Souza; Ana Paula Evangelista Meira; Laís Teixeira de Abreu Souza

Temporomandibular joint; Object (grammar); Clinical Practice; Context (archaeology); Medicine

2026-04-01https://doaj.org/article/23224375bf4f49b2bf33d17dde47354fDOAJ (DOAJ: Directory of Open Access Journals) 20261Improving power sharing and parallel operation of four-wire voltage source convertersDalmo C. Silva Júnior; JOSUÉ BISPO DA SILVA; Janaína G. Oliveira; Pedro M. de Almeida

Converters; Power (physics); Voltage; Voltage source; Switched-mode power supply; Power sharing; Capacitor; Switching power; Electrical engineering; Electronic engineering; Computer science; Engineering

2026-04-30https://doi.org/10.1007/s00202-026-03615-zElectrical Engineering 20261Upcycling invasive sun coral (Tubastraea spp.) waste: Microstructure and performance of innovative coral-based cementitious compositesSun coral ( Tubastraea spp. ) is an invasive marine coral species responsible for severe ecological disturbances in marine ecosystems, resulting in high removal and monitoring costs in coastal infrastructure. Although previous studies have explored the use of this material in cementitious composites, the main novelty of this research lies in investigating the incorporation of sun coral waste as a supplementary cementitious material (SCM) in clinker-based systems. In this study, clinker was partially replaced at levels of 0%, 5%, 10%, 15% and 25% (by mass). Physicochemical properties, dimensional and mass variations of these innovative cementitious composites were explained based on calorimetry, X-ray diffraction (XRD), thermogravimetric (TG), derivative thermogravimetry (DTG) and mercury intrusion porosimetry (MIP) analyses. The results demonstrated that the sun coral waste affects cementitious systems mainly through physical mechanisms, nucleation effects, improved water redistribution, and pore refinement. Furthermore, calcium carbonate (CaCO 3 ) contributes to monosulphate (AFm) phase transformations, leading to the formation of ettringite (AFt) and monocarbonate (Mc) phases, which are associated with enhanced phase stability and improved microstructural integrity. The observed effects were strongly dependent on the replacement level and application conditions. These findings indicate that sun coral waste presents potential as a novel supplementary cementitious material, provided that its use is technically controlled, contributing to the valorisation of marine waste and the development of more sustainable cement-based materials.RENAN DIAS COUTO; Madeleing Taborda Barraza; Gustavo Henrique Nalon; Jorge de Brito; Markssuel Teixeira Marvila; Afonso Rangel Garcez de Azevedo

Microstructure; Coral; Cementitious; Toughness; Materials science; Composite material

2026-05-01https://doi.org/10.1016/j.jobe.2026.116210Journal of Building Engineering 20261Telehealth Usability, Engagement Patterns, and Technical Infrastructure in Managing Noncommunicable Diseases Among Health Care Professionals in Brazil, Ghana, Honduras, and the United Kingdom: Multinational Cross-Sectional StudyBackground: Noncommunicable diseases (NCDs) account for over 70% of global deaths, with hypertension and diabetes serving as major contributors. The COVID-19 pandemic disrupted traditional health care services for NCDs and highlighted telehealth as a crucial alternative. Telehealth-encompassing synchronous and asynchronous electronic communication to deliver clinical services remotely-can overcome geographical barriers and enhance patient engagement. However, telehealth usability among health care professionals (HCPs) remains under-studied across low-, middle-, and high-income countries. Objective: This study aimed to examine which telehealth engagement patterns, technical infrastructure factors, and user profiles were most strongly associated with usability among HCPs and to descriptively compare these across 4 diverse countries: Brazil (high- to middle-income country), Ghana (low- to middle-income country), Honduras (low- to middle-income country), and the United Kingdom (high-income country). Methods: A multinational cross-sectional survey was conducted with 290 HCPs across 4 countries. Participants completed the System Usability Scale and provided data on telehealth engagement (eg, frequency, duration, and number of systems used), technical infrastructure (connection stability and support satisfaction), and their user profile (demographics, job role, and training received). Descriptive statistics summarized these patterns and usability scores. Multiple linear regression with bootstrap-based sensitivity analyses identified factors associated with telehealth usability. Given the nonprobability design, no formal inferential comparisons were made between countries. Instead, observed patterns were reported descriptively. Results: Higher telehealth usability scores were associated with greater connection stability (b=5.06, 95% CI 3.06-7.05), higher satisfaction with online support information (b=5.02, 95% CI 3.27-6.75), more frequent use (b=3.05, 95% CI 1.36-4.73), longer duration of use (b=1.59, 95% CI 0.49-2.68), and being a physician by profession (b=3.82, 95% CI 0.23-7.40). Average usability scores were highest among users in Ghana (mean 79.75, SD 14.19) and the United Kingdom (mean 79.00, SD 14.71), followed by Brazil (mean 72.01, SD 14.62) and Honduras (mean 63.09, SD 15.57). According to System Usability Scale guidelines, scores corresponded to "good" usability for users in Ghana, the United Kingdom, and Brazil and were below the "good" threshold for users in Honduras. While most users in Ghana (97/111, 87.4%), Honduras (31/38, 81.6%), and Brazil (57/80, 70.4%) reported using only 1 telehealth system, two-thirds of UK users (40/60, 66.7%) reported using 2 or more systems. User profiles also varied; prepandemic use was highest in Ghana (84/111, 75.7%) and lowest in Honduras (7/38, 18.4%). Other engagement patterns across countries were reported. Conclusions: Telehealth usability is driven by technical infrastructure reliability, a robust online support infrastructure, and an "experience effect" from frequent and long-term engagement. Descriptive differences in engagement patterns and infrastructure highlight the need for tailored strategies to address setting-specific challenges. These are essential to optimize telehealth integration and improve health care outcomes for patients with NCDs worldwide.Ken Brackstone; Roberta Lins Gonçalves; Adriana Silvina Pagano; Zilma Silveira Nogueira Reis; Seth Kwaku Afagbedzi; Lysien Ivania Zambrano; Tainá Costa Pereira Lopes; Sarah Almeida Cordeiro; Julia Macedo Nunes; Wagner Meira Jr; James Batchelor; Antonio Luiz Pinho Ribeiro

Telehealth; Multinational corporation; Health care; eHealth; Telemedicine; Health professionals; Digital health; Business; Public relations; Nursing

2026-04-30https://doi.org/10.2196/64070Journal of Medical Internet Research 20261Discovery of an efficacious 2-ethyl-4-phenylthiazole derivative against acute Chagas disease via multiparametric hit-to-lead optimization and in vivo efficacyThis work describes the hit-to-lead optimization of the 2-ethyl-4-phenylthiazole class against Trypanosoma cruzi, the causative agent of Chagas disease. Compound LC-6 (1), previously identified in silico and in vitro against epimastigotes, was confirmed here as an antichagasic hit due to its sub-micromolar potency against intracellular amastigotes. The ensuing structure-activity relationship identified five additional derivatives with promising activity against the Tulahuen strain, and subsequent assessment against strains from several Trypanosoma cruzi DTUs revealed that 1, 2 and 16 exerted nanomolar potency against the CL-Brener strain. The potency of these three compounds was complemented with a trypanocidal mechanism of action against the Dm28c-Luc and CL-Brener strains, highlighted by washout assays. However, assessing the pharmacokinetic profile of this series revealed a metabolic liability for 1 and most 2-ethyl-4-phenylthiazoles, despite an otherwise satisfactory ADME profile. Compound 2 was able to overcome this liability, displaying a sevenfold improvement in metabolic stability over 1. Therefore, 2 was selected for in vivo studies in a murine model of acute Chagas disease, in which it ultimately achieved an 84% reduction of the parasitemia in BALB/c mice. Thus, 2 was successfully identified as a new lead compound against Chagas disease.Thibault Joseph William Jacques Dit Lapierre; Daniela de Melo Resende; Felipe da Silva Mendonça de Melo; Alexandra Maria dos Santos Carvalho; Douglas Davison da Silva Oliveira; Simone Michelan‐Duarte; Rafael Consolin Chelucci; Paula Derksen Macruz; Lucas Abreu Diniz; Rafaela Salgado Ferreira; Alice Lima Continentino; Gabriela Louise da Silva Moreira; Ítalo de Lucas da Silva Xavier; João Paulo Figueiró Longo; Cláudia M. Calvet; Eduardo Jorge Pilau; Leonardo L. G. Ferreira; Adriano D. Andricopulo; Bruno Junior Neves; Silvane Maria Fonseca Murta; Izabela Marques Dourado Bastos; Celso de Oliveira Rezende Júnior

Chagas disease; In vivo; Derivative (finance); In vitro; Ex vivo; Chemistry; Pharmacology; Immunology

2026-04-30https://doi.org/10.1016/j.ejmech.2026.118888European Journal of Medicinal Chemistry 20261Efficacy and Safety of Mogamulizumab for Cutaneous T-Cell Lymphomas: A Systematic Review and Meta-AnalysisAyomide Lawal; Amanda Ribeiro Rangel; Advait Raja; Maria Antônia Costa Cruz Akabane; Nathália Veloso Lana; Falaknaz Saleem; Ana Paula Pedroso Junges; Kélen Klein Heffel

MEDLINE; Clinical trial; Monoclonal; Monoclonal antibody; Clinical Practice; Medicine; Dermatology

2026-05-01https://doi.org/10.1016/j.clml.2026.04.014Clinical Lymphoma Myeloma & Leukemia 20261EUGENIA SOCIODIGITAL DA PESSOA IDOSA NO SISTEMA MULTIPOLAR SOB A LENTE DOS DIREITOS HUMANOS E CONSTITUCIONAISEste estudo visa descortinar a invisível exclusão estrutural dos senescentes na fascinante e paradoxalmente desafiadora Era Tecnológica, resultante da sua falta de letramento digital, da vulnerabilidade informacional e insuficiência de políticas de inclusão, que sacrificam sua igualdade material, a proteção de seus dados pessoais, seu acesso à justiça, mutilando sua liberdade e dignidade humana no estado democrático de direito. A questão-problema perquire: “Quais estratagemas devem ser adotados para ruptura das homéricas muralhas de exclusão digital erguidas na Sociedade 5.0 contra a dignidade das pessoas idosas? A metodologia é a qualitativa, com a análise normativa e método dedutivo. O exercício da cidadania e dos direitos humanos pela Terceira Idade hodiernamente parece reprisar um genuíno cover da Guerra de Troia a partir da virtualização dos serviços essenciais nas esferas pública e privada, expondo-os ao poder dominante dos algoritmos via Machine Learning que manipulam sua liberdade em todas as dimensões, inclusive sua vontade política. Na Nova Ordem Mundial com multifacetados polos de poder tecnológico, político, social, educacional e militar, a governança digital desafia o constitucionalismo global e a tutela dos direitos humanos. Concluiu-se que a atual corrida tecnológica da Sociedade Informacional conclama por urgentes balizas éticas, jurídicas e humanizadas, onde a comunidade internacional, numa rede de cooperação plural, institua parâmetros que configurem um mínimo ético de inclusão digital, a exemplo da Lei da Inteligência Artificial (AIA) promulgada na União Europeia. Assim, impedirão o cruel avanço da Eugenia Sociodigital, que dizima a democracia, a vida e a dignidade humana das pessoas sênior.Teodolina Batista da Silva Cândido Vitório; Guilherme Matias da Silva

Power (physics); Trunking; Fundamental rights; Freedom of expression; Humanities; Political science; Philosophy

2026-05-02https://doi.org/10.5281/zenodo.19979053Zenodo (CERN European Organization for Nuclear Research) 20261Relationship Between Weekly Training Load and Pre-Match Neuromuscular Performance in U21 Football PlayersObjective: To analyze the relationship between weekly accumulated external load and pre-match neuromuscular performance assessed through the countermovement jump (CMJ), in under-21 (U21) football players across 10 competitive microcycles. Methods: Sixteen U21 football players (age: 18.9 ± 0.42 years; height: 180 ± 6.3 cm; body mass: 78.5 ± 8.5 kg) from a Chilean professional club were monitored over 10 consecutive weeks. In each microcycle, the relationship between changes in neuromuscular performance estimated from CMJ-derived variables and two components of external load was analyzed: (1) weekly accumulated external load and (2) the acute–chronic workload ratio (ACWR). External load variables included total distance (TD), high-speed running distance (HSR), accelerations (ACC), decelerations (DC), and PlayerLoad (PL). CMJ variables included jump height (JH), modified reactive strength index (RSI-mod), and peak eccentric velocity (PEV). Performance changes were calculated as the percentage change (Δ%) between MD + 2 (start of the microcycle) and MD − 1 (pre-match). Pearson or Spearman correlation coefficients were applied depending on data distribution. Results: Significant negative associations were observed between weekly accumulated external load and changes in CMJ performance. Reductions in JH were associated with TD, HSR, ACC, and PL. Similar patterns were found for RSI-mod, while PEV showed a particularly strong association with ACC. Additionally, ACWR demonstrated significant negative relationships with CMJ changes, especially for HSR, ACC, and PL. Conclusions: Higher weekly accumulated external loads and elevated ACWR, particularly in high-intensity metrics such as high-speed running and accelerations, are associated with impaired pre-match neuromuscular performance. Consequently, monitoring CMJ-derived variables alongside external load data is recommended to manage fatigue and optimize match readiness in young football players.Rodrigo Villaseca-Vicuña; Pablo Merino-Muñoz; John Cursach; Natalia Escobar; Guillermo Cortes-Rocco; Felipe Inostroza-Ríos; Felipe Hermosilla-Palma; Jorge Perez-Contreras

Workload; Jump; Football players; Vertical jump; Club; Jumping; Football; Plyometrics; Physical medicine and rehabilitation; Physical therapy; Mathematics; Medicine; Strength training; Spearman's rank correlation coefficient

2026-05-01https://doi.org/10.3390/biomechanics6020040Biomechanics 20261EUGENIA SOCIODIGITAL DA PESSOA IDOSA NO SISTEMA MULTIPOLAR SOB A LENTE DOS DIREITOS HUMANOS E CONSTITUCIONAISEste estudo visa descortinar a invisível exclusão estrutural dos senescentes na fascinante e paradoxalmente desafiadora Era Tecnológica, resultante da sua falta de letramento digital, da vulnerabilidade informacional e insuficiência de políticas de inclusão, que sacrificam sua igualdade material, a proteção de seus dados pessoais, seu acesso à justiça, mutilando sua liberdade e dignidade humana no estado democrático de direito. A questão-problema perquire: “Quais estratagemas devem ser adotados para ruptura das homéricas muralhas de exclusão digital erguidas na Sociedade 5.0 contra a dignidade das pessoas idosas? A metodologia é a qualitativa, com a análise normativa e método dedutivo. O exercício da cidadania e dos direitos humanos pela Terceira Idade hodiernamente parece reprisar um genuíno cover da Guerra de Troia a partir da virtualização dos serviços essenciais nas esferas pública e privada, expondo-os ao poder dominante dos algoritmos via Machine Learning que manipulam sua liberdade em todas as dimensões, inclusive sua vontade política. Na Nova Ordem Mundial com multifacetados polos de poder tecnológico, político, social, educacional e militar, a governança digital desafia o constitucionalismo global e a tutela dos direitos humanos. Concluiu-se que a atual corrida tecnológica da Sociedade Informacional conclama por urgentes balizas éticas, jurídicas e humanizadas, onde a comunidade internacional, numa rede de cooperação plural, institua parâmetros que configurem um mínimo ético de inclusão digital, a exemplo da Lei da Inteligência Artificial (AIA) promulgada na União Europeia. Assim, impedirão o cruel avanço da Eugenia Sociodigital, que dizima a democracia, a vida e a dignidade humana das pessoas sênior.Teodolina Batista da Silva Cândido Vitório; Guilherme Matias da Silva

Power (physics); Trunking; Fundamental rights; Freedom of expression; Humanities; Political science; Philosophy

2026-05-02https://doi.org/10.5281/zenodo.19979052Zenodo (CERN European Organization for Nuclear Research) 20261Flipped Classroom Versus Traditional Lecture for Teaching Focused Cardiac Ultrasound: A Prospective Study in Undergraduate Medical EducationRaquel Oliveira Carmo

Flipped classroom; Teaching method; Blended learning; Undergraduate education; Problem-based learning; Medical education; Medicine; Psychology

2026-05-07https://doi.org/10.5281/zenodo.20030095Zenodo (CERN European Organization for Nuclear Research) 20261Normative Values and Measurement Properties of the Bed Bridge TestOBJECTIVES: To establish normative values and develop reference equations for 4 variants of the Bed Bridge Test (BBT) in healthy adults, and to evaluate their measurement properties, including reliability and validity. DESIGN: Methodological cross-sectional study. SETTING: University-based research setting. PARTICIPANTS: A total of 120 healthy adults (18-79y), equally distributed by sex, were included. Participants were independent in daily activities and free from significant clinical conditions. INTERVENTIONS: Participants performed 4 randomized variants of the BBT: 5 repetitions (5×BBT), 10 repetitions (10×BBT), 30 seconds (30s BBT), and 60 seconds (60s BBT), following standardized procedures. MAIN OUTCOME MEASURES: Normative values, reference equations, test-retest reliability (intraclass correlation coefficient), measurement error, floor and ceiling effects, and criterion and construct validity. RESULTS: Normative values were established according to age and sex. Performance declined with age and was higher in men across all variants. Reference equations explained 29%-46% of performance variability, with age and sex as significant predictors. The equations were: 5×BBT=3.49-1.96×(sex)+0.07×age; 10×BBT=6.93-4.51×(sex)+0.14×age; 30s BBT=44.21+9.36×(sex)-0.36×age; and 60s BBT=80.28+20.38×(sex)-0.62×age. All BBT variants demonstrated good to excellent reliability (intraclass correlation coefficient=0.87-0.95), with acceptable floor and ceiling effects. Criterion validity was supported by moderate to strong correlations with sit-to-stand tests. CONCLUSION: The BBT variants demonstrated adequate reliability and validity for assessing functional capacity in healthy adults. The normative values and reference equations provide preliminary support for clinical interpretation and may assist in identifying functional limitations and guiding rehabilitation strategies, particularly in individuals with reduced mobility.Larissa Guimarães Paiva; Nara Batista de Souza; Eduarda Aparecida Silva Coimbra; Sabrina Campos Furtado; Levy Soares da Silva Junior; Túlio Medina Dutra de Oliveira; Cristino Carneiro Oliveira; Anderson José; Carla Malaguti

Normative; Ceiling effect; Ceiling (cloud); Reliability (semiconductor); Rehabilitation; Construct validity; Test (biology); Structural equation modeling; Bridge (graph theory); Psychology; Statistics; Item response theory; Physical medicine and rehabilitation; Test validity; Criterion validity; Reference values; Mathematics; Social psychology; Covariate; Validity; Psychometrics; Physical therapy; Outcome (game theory)

2026-05-01https://doi.org/10.1016/j.apmr.2026.04.029Archives of Physical Medicine and Rehabilitation 20261Low methane emissions from nutrient‐rich former river channels in a hydrologically managed dryland deltaAbstract Anthropogenic stresses in dryland regions can alter hydrology, salinization, and biogeochemical processes. How these pressures influence methane (CH 4 ) cycling and emissions from aquatic ecosystems remains poorly understood. Over the course of 1 year, we measured diffusive and ebullitive CH 4 emissions from resacas—shallow, hydrologically managed distributary channels prevalent throughout the Lower Rio Grande Valley along the US–Mexico border. Despite warm, nutrient‐rich waters, CH 4 emissions from resacas were low, and more comparable to rates observed in estuarine systems. CH 4 fluxes were positively related to temperature but negatively related to salinity and rainfall. Elevated salinity, driven by evaporation and source water from the salinized Rio Grande, may suppress methanogenesis. These findings highlight the complex interplay of salinity, hydrology, and management in shaping aquatic CH 4 emissions from dryland regions. As dryland water bodies face growing salinization and warming temperatures, resacas offer valuable insight into CH 4 dynamics in increasingly altered freshwater ecosystems.Siena Stassi; Jude A. Benavides; Chu‐Lin Cheng; Marcelo Gomes da Silva; Nicholas E. Ray; Nathan Barros; Rafael M. Almeida

Biogeochemical cycle; Methane emissions; Aquatic ecosystem; Delta; Hydrology (agriculture); Ecosystem; Salinity; Estuary; Methane; Wetland; Environmental science; Climate change; Dryland salinity; Greenhouse gas; Groundwater; Methanogenesis; Saltwater intrusion; Soil salinity; Lead (geology); Global warming; River delta; Biogeochemistry; Evaporation

2026-05-01https://doi.org/10.1002/lol2.70131Limnology and Oceanography Letters 20261Modelo de transferência de P-tau entre regiõesLetícia Ribeiro; Eliana C B Toscano; Marcelo Lobosco; Bárbara de Melo Quintela

2026-05-06https://doi.org/10.5281/zenodo.20044836Zenodo (CERN European Organization for Nuclear Research)

20261Dataset for "Influence diagnostics and outlier tests for log-Birnbaum-Saunders regression models"Camila Zeller

Outlier; Regression; Regression analysis; Linear regression; Anomaly detection; Robust regression; Computer science; Statistics; Artificial intelligence; Data mining

2026-05-05https://doi.org/10.5281/zenodo.20042908Zenodo (CERN European Organization for Nuclear Research) 20261Spacetime Densification Theory: A Unified Quantum Statistical Framework for Gravity, Cosmic Acceleration, and Galactic Phenomenology from Discrete Spacetime MicrostructureAbstract Reconciling gravitation with the quantum structure of nature remains an open problem in fundamental physics. We develop Spacetime Densification Theory (SDT) as a structured framework in which gravitational dynamics emerge from a discrete and saturable spacetime substrate composed of fundamental excitations, termed spaceons. At macroscopic scales, SDT is formulated as a scalar–tensor theory with a non-minimally coupled density field. By embedding the effective action within the Horndeski class, the theory preserves second-order field equations and avoids higher-derivative Ostrogradsky instabilities. In the Einstein frame, gradients of the spaceon density generate an additional attractive component, referred to here as the densification force. At microscopic scales, the spacetime vacuum is modeled as a quantum lattice gas of hard-core bosonic spaceons. From the grand canonical ensemble, we derive a universal equation of state for the spacetime medium. In the low-density regime, the cohesive sector yields an effective negative-pressure component compatible with late-time cosmic acceleration once normalized to the observed cosmological background. In the high-density regime, the packing contribution rises sharply as the medium approaches saturation, suggesting a possible mechanism for regulating gravitational collapse. The same framework also motivates a characteristic acceleration scale of order cH₀, linking the cosmological vacuum sector to low-acceleration galactic phenomenology. In the nonlinear halo regime, the scalar sector admits an asymptotic logarithmic overdensity profile associated with flat rotation curves and a BTFR-like scaling relation. These results should be interpreted with appropriate caution: the cosmological vacuum sector is calibrated rather than derived from a deeper ultraviolet theory, the galactic phenomenology has not yet been systematically confronted with full observational datasets, and the electromagnetic extension considered here remains exploratory at the effective-field-theory level. The theory is also discussed in relation to the Hubble tension: the characteristic acceleration scale a* ~ cH₀ emerging from the cosmological normalization of the cohesive vacuum sector is numerically close to the locally measured value, and SDT provides a late-time emergent-vacuum framework that is qualitatively relevant to the persistent discrepancy — now standing at 7.1σ between the local Distance Network determination and the early-Universe+ΛCDM value — between local and early-Universe measurements of H₀; a full quantitative reconciliation, however, has not yet been achieved. SDT should therefore be regarded not as a completed theory of quantum gravity, but as a mathematically structured and falsifiable framework in which spacetime microstructure, effective gravity, and selected cosmological and astrophysical regimes can be studied within a common setting.Paulo G.A. Suassuna

Spacetime; Quantum field theory in curved spacetime; Gravitation; Linearized gravity; Phenomenology (philosophy); Spacetime topology; Hierarchy problem; General relativity; Quantum gravity; Physics; Theoretical physics; Classical mechanics; Quantum field theory; Scalar field; Gravitational field; Causal sets; Cosmology

2026-05-05https://doi.org/10.5281/zenodo.20039123Zenodo (CERN European Organization for Nuclear Research) 20261A Multi-Objective Optimization Framework for Energy-Efficient Social Housing in Brazil: Balancing Construction Cost and Thermal Comfort Across Diverse Bioclimatic ZonesAchieving thermal comfort in social housing under variable and changing climates presents a critical challenge for sustainable building design and energy efficiency. This study develops a simulation-based multi-objective optimization framework to support early-stage design of climate-resilient social housing in Brazil, aiming to reduce thermal discomfort and associated mechanical conditioning energy demands. The goal is to identify building envelope configurations that minimize total construction cost while maximizing annual thermal comfort hours, thereby reducing the need for active heating and cooling systems. A reference single-room prototype is simulated in EnergyPlus for five cities representing distinct climatic zones. A wide range of construction alternatives for walls, roofs, slabs, and glazing are evaluated, with costs derived from the national SINAPI database and comfort assessed using the ASHRAE adaptive model based on operative temperature. The optimization, performed with the NSGA-II algorithm (via PyMOO), generates city-specific Pareto fronts that quantify the inherent trade-off between cost and comfort. Results show that optimal solutions range from approximately R$4800 to R$8900 in cost, achieving between 1350 and 3550 annual comfort hours, heavily influenced by local climate. Frequency analysis reveals that wall and roof assemblies are the most influential design variables. The proposed framework provides a transparent, data-driven decision-support tool for defining cost-effective, climate-adapted construction standards, contributing directly to sustainable housing policy, energy poverty reduction, and the development of resilient, low-carbon built environments aligned with the UN Sustainable Development Goals (SDG), particularly SDG 7 (Affordable and Clean Energy), SDG 11 (Sustainable Cities and Communities), and SDG 13 (Climate Action).Rhayssa Padilha Alves; Edílson Alves Silva; Wanderlei Malaquias Pereira; Mayara C. Lima; Ed Carlo R. Paiva; Emeli Lalesca Aparecida da Guarda; Matteo Bodini; Leonardo Goliatt

Thermal comfort; ASHRAE 90.1; Building envelope; Range (aeronautics); Roof; Cooling load; Built environment; Pareto principle; Public housing; Architectural engineering; Multi-objective optimization; Building design; Sustainability; Engineering; Civil engineering; Sustainable development; Envelope (radar); Passive solar building design; Efficient energy use; Building science; Energy performance; Computer science; Environmental economics; Building information modeling; Building model

2026-05-04https://doi.org/10.3390/su18094521Sustainability 20261Flipped Classroom Versus Traditional Lecture for Teaching Focused Cardiac Ultrasound: A Prospective Study in Undergraduate Medical EducationRaquel Oliveira Carmo

Flipped classroom; Teaching method; Blended learning; Undergraduate education; Problem-based learning; Medical education; Medicine; Psychology

2026-05-04https://doi.org/10.5281/zenodo.20030096Zenodo (CERN European Organization for Nuclear Research) 20261Spacetime Densification Theory: A Unified Quantum Statistical Framework for Gravity, Cosmic Acceleration, and Galactic Phenomenology from Discrete Spacetime MicrostructureAbstract Reconciling gravitation with the quantum structure of nature remains an open problem in fundamental physics. We develop Spacetime Densification Theory (SDT) as a structured framework in which gravitational dynamics emerge from a discrete and saturable spacetime substrate composed of fundamental excitations, termed spaceons. At macroscopic scales, SDT is formulated as a scalar–tensor theory with a non-minimally coupled density field. By embedding the effective action within the Horndeski class, the theory preserves second-order field equations and avoids higher-derivative Ostrogradsky instabilities. In the Einstein frame, gradients of the spaceon density generate an additional attractive component, referred to here as the densification force. At microscopic scales, the spacetime vacuum is modeled as a quantum lattice gas of hard-core bosonic spaceons. From the grand canonical ensemble, we derive a universal equation of state for the spacetime medium. In the low-density regime, the cohesive sector yields an effective negative-pressure component compatible with late-time cosmic acceleration once normalized to the observed cosmological background. In the high-density regime, the packing contribution rises sharply as the medium approaches saturation, suggesting a possible mechanism for regulating gravitational collapse. The same framework also motivates a characteristic acceleration scale of order cH₀, linking the cosmological vacuum sector to low-acceleration galactic phenomenology. In the nonlinear halo regime, the scalar sector admits an asymptotic logarithmic overdensity profile associated with flat rotation curves and a BTFR-like scaling relation. These results should be interpreted with appropriate caution: the cosmological vacuum sector is calibrated rather than derived from a deeper ultraviolet theory, the galactic phenomenology has not yet been systematically confronted with full observational datasets, and the electromagnetic extension considered here remains exploratory at the effective-field-theory level. The theory is also discussed in relation to the Hubble tension: the characteristic acceleration scale a* ~ cH₀ emerging from the cosmological normalization of the cohesive vacuum sector is numerically close to the locally measured value, and SDT provides a late-time emergent-vacuum framework that is qualitatively relevant to the persistent discrepancy — now standing at 7.1σ between the local Distance Network determination and the early-Universe+ΛCDM value — between local and early-Universe measurements of H₀; a full quantitative reconciliation, however, has not yet been achieved. SDT should therefore be regarded not as a completed theory of quantum gravity, but as a mathematically structured and falsifiable framework in which spacetime microstructure, effective gravity, and selected cosmological and astrophysical regimes can be studied within a common setting.Paulo G.A. Suassuna

2026-05-05https://doi.org/10.5281/zenodo.20039124Zenodo (CERN European Organization for Nuclear Research) 20261Modelo de transferência de P-tau entre regiõesLetícia Ribeiro; Eliana C B Toscano; Marcelo Lobosco; Bárbara de Melo Quintela

2026-05-06https://doi.org/10.5281/zenodo.20044835Zenodo (CERN European Organization for Nuclear Research)

20261Multilevel Political Connections and Interest Intermediation: Identifying Political Alliances with Social Media DataIt is common, both in unitary and federal countries, for politicians at different levels to cooperate in pursuit of mutual benefits. But how can we identify who cooperates with whom to investigate the factors behind these alliances? This article proposes a novel strategy to detect alliances between local executive leaders and national legislators using mayors’ social media data. Drawing on over two million posts from nearly 2000 Brazilian mayors, we develop, through a supervised machine learning model, an indicator that measures the strength of mayor-congressperson relationships. Our findings show that most connections are relatively weak, though partisanship is positively associated with stronger ties. Our approach offers a low-cost, replicable alternative to traditional methods for studying political intermediation. It advances the understanding of multilevel political dynamics in presidential systems with strong local executives and highlights the role of local elected officials as key, yet often overlooked, brokers in comparative politics.Lucas Gelape; Fernando Meireles; Marta Mendes da Rocha; Guilherme de Abreu Duque

Politics; Unitary state; Presidential system; Social media; Multilevel model; Political communication; Political science; Public relations; Sociology; Political economy; Big data

2026-05-05https://doi.org/10.1177/1866802x261445940Journal of Politics in Latin America 20261Dataset for "Influence diagnostics and outlier tests for log-Birnbaum-Saunders regression models"Camila Zeller

Outlier; Regression; Regression analysis; Linear regression; Anomaly detection; Robust regression; Computer science; Statistics; Artificial intelligence; Data mining

2026-05-05https://doi.org/10.5281/zenodo.20042909Zenodo (CERN European Organization for Nuclear Research) 20261An IoT-Based Remote Monitoring Information System for Hydroponic Greenhouses in the Context of Smart FarmingResearch Context: Climate change and population growth pose challenges to food security, requiring innovations in agriculture. Greenhouses emerge as an alternative for controlled cultivation, and hydroponics optimizes water and space usage while allowing precise nutrient management. Scientific and/or Practical Problem: However, hydroponic systems require investment, specialized technical knowledge, and ongoing monitoring. They are vulnerable to energy failures, nutrient imbalances, and environmental variations, leading to rapid production losses, particularly for small producers with limited resources. Proposed Solution and/or Analysis: This work proposes a low-cost IoT-based remote monitoring information system for hydroponic greenhouses. The system integrates sensors connected to Arduino, transmitting real-time data to the ThingSpeak cloud platform. The application enables the visualization of critical variables, provides automatic alerts in the event of deviations, and facilitates remote calibration of pH and electrical conductivity sensors. Related IS Theory: The solution aligns with the principles of Smart Farming and socio-technical IS theory. By supporting decision-making with real-time data and integrating technology with organizational and social dimensions, it reinforces the role of IS in promoting sustainability and efficiency in agriculture. Research Method: An experimental prototype was deployed in a real hydroponic greenhouse, monitoring two reservoirs and cultivation benches. Data from sensors were collected, transmitted via Wi-Fi, stored in ThingSpeak, and consumed by the mobile system for validation under production conditions. Summary of Results: The system successfully monitored variables such as temperature, pH, conductivity, solution volume, turbidity, and flow. Alerts enabled timely corrective actions, including adjustments to nutrient and management of excessive conductivity, while ThingSpeak dashboards supported historical analysis. Contributions and Impact to IS area: The research demonstrates a low-cost, modular IoT infrastructure integrated with a mobile interface for agriculture. It contributes to IS by bridging technology, organization, and social impact, offering accessible tools that support decision-making, resource efficiency, and preventive management in food production.Débora Duarte; Victor Ströele; Fabricio Soares; Ronney Castro; Luciana Campos; Regina Maciel Braga

Context (archaeology); Precision agriculture; Sustainability; Hydroponics; Greenhouse; Population; Production (economics); Information system; Cloud computing; Sustainable agriculture; Computer science; Unavailability; Remote sensing; Agriculture; Raw data

2026-05-05https://doi.org/10.5753/sbsi.2026.248347 20261Rail flash butt welding process: Effect of the preheating stage on the heat-affected zoneFlash butt welding is an important rail welding process for the construction and maintenance of railroads. However, despite the efforts to improve the parent metal rail quality, the rail welded zones are still prone to being sensitive to defects. This work focuses on the Preheating process stage, and it presents a study on the influence of this stage on the heat-affected zone (HAZ). Two types of rail base metal were studied: Premium and Super-premium. A novel categorization and assessment of the process variables effects on the HAZ width and its minimum hardness are presented. Taguchi’s method was applied to analyze the effect of three welding parameters (Current Pulse, Number of Heating Impulses and Upset Force) on the HAZ. The results showed that the effect of the heat input generated by the preheating stage also contributes to the HAZ formation and cannot be neglected. It was demonstrated that the parameters in the preheating stage influence the HAZ width (40% reduction in HAZ) and its Minimum Hardness value (raised by 10%). Preheating stage can be used to control and optimize the width and the minimum hardness of the HAZ.Moisés Luiz Lagares Júnior; Tiago Carvalho Tepedino Cruz; Hélio Goldenstein; Roberto Malheiros Moreira Filho; Luiz Henrique Dias Alves

Welding; Flash welding; Upset; Butt welding; Heat-affected zone; Base metal; Flash (photography); Stage (stratigraphy); Materials science; Metallurgy; Friction welding; Work (physics); Process (computing); Composite material; Electric resistance welding; Mechanical engineering

2026-05-06https://doi.org/10.1177/09544089261448117Proceedings of the Institution of Mechanical Engineers Part E Journal of Process Mechanical Engineering 20261Assessing the robustness of market-based capacity valuation for variable renewable energy: A multi-year analysisRené Báez-Santana; Bruno Dias; Víctor Ocaña-Guevara; João Nacif Soares; Miguel Aybar-Mejia; Máximo Domínguez-Garabitos

Variable renewable energy; Renewable energy; Scarcity; Robustness (evolution); Wind power; Remuneration; Photovoltaic system; Variable (mathematics); Environmental economics; Econometrics; Valuation (finance); Nameplate capacity; Economics; Market price; Market value; Environmental science; Capacity planning

2026-01-01https://doi.org/10.2139/ssrn.6727029SSRN Electronic Journal 20261GOVERNANÇA AMBIENTAL E MUDANÇAS CLIMÁTICAS: UMA REVISÃO DA LITERATURA SOBRE INSTRUMENTOS JURÍDICOS DE PROTEÇÃO AMBIENTALO presente artigo tem como objetivo analisar, por meio de uma revisão da literatura, os principais instrumentos jurídicos utilizados na governança ambiental para o enfrentamento das mudanças climáticas. A justificativa do estudo reside na necessidade de compreender como os mecanismos normativos e institucionais têm sido mobilizados para fortalecer a proteção ambiental em diferentes níveis de governança. A problemática que orienta a pesquisa consiste em identificar em que medida os instrumentos jurídicos existentes são capazes de responder de forma eficaz aos desafios impostos pelas mudanças climáticas. Metodologicamente, trata-se de uma revisão narrativa da literatura, com análise de produções acadêmicas e documentos normativos nacionais e internacionais que abordam governança ambiental, direito ambiental e políticas climáticas. Os resultados indicam que os instrumentos jurídicos, tais como acordos internacionais, legislações ambientais, políticas públicas e mecanismos de regulação ambiental, desempenham papel fundamental na estruturação da governança climática, embora ainda enfrentem limitações relacionadas à implementação, fiscalização e integração entre diferentes níveis institucionais. Conclui-se que o fortalecimento da governança ambiental depende da articulação entre instrumentos jurídicos eficazes, cooperação internacional e mecanismos institucionais capazes de garantir a efetividade das políticas ambientais diante da complexidade dos desafios climáticos.Ellen de Moraes e Silva; Kamilly de Souza Cintrão; Gedean de Souza Cruz; ⁠Bruno Godoy de Melo; Débora Cristina Guimarães Albuquerque; Mickaelly Christinne Guimarães; Dimis da Costa Braga; Marcelo Hermenegildo Moreira de Oliveira

Government (linguistics); Legislation; Order (exchange); Action (physics); Politics; Quality (philosophy); Process (computing); Work (physics); Political science; Public administration; Welfare economics; Public relations

2026-05-06https://doi.org/10.70773/revistatopicos/778094860Revista Tópicos. 20261A IGREJA CRISTÃ CONTEMPORÂNEA DE BELO HORIZONTE E A LUTA LGBT+: CAMINHOS OPOSTOS?O artigo apresenta as proximidades de pautas e os distanciamentos da Igreja Cristã Contemporânea de Belo Horizonte - MG, com a luta da população LGBT+ no Brasil. Trata-se se uma pesquisa de caráter investigativo qualitativo, e o recurso técnico escolhido foi a entrevista. Como método de estudo, seguimos as orientações de Vergara (2009), Lakatos e Marconi (2007) e Goldenberg (2004). As referências teóricas se valem de grandes autores que debatem a temática, como Natividade (2025) e Costa (2022). Fizemos uso dos materiais encontrados no site oficial da igreja, informações postadas no facebook e Instagram. As igrejas denominadas inclusivas abrem espaços de acolhimento e conforto espiritual para pessoas LGBT+, que os faz sentir parte de uma comunidade religiosa. Porém, o estudo mostra que são poucas as aproximações com as pautas e conquistas do movimento LGBT+ no Brasil. Esta pesquisa oferece aporte para ampliação deste debate, e fomenta, no campo científico, propostas de estudos críticos e profícuos sobre a relação entre fé e sexualidade humana.Andréa Kelmer de Barros; André Brandão

Context (archaeology); Precept; Confessional; Humanities; Philosophy; Sociology; Art

2026-05-06https://doi.org/10.70773/revistatopicos/777864444Revista Tópicos. 20261Flipped Classroom Versus Traditional Lecture for Teaching Focused Cardiac Ultrasound: A Prospective Study in Undergraduate Medical EducationRaquel Oliveira Carmo

Flipped classroom; Teaching method; Blended learning; Undergraduate education; Problem-based learning; Medical education; Medicine; Psychology

2026-05-07https://doi.org/10.5281/zenodo.20073670Zenodo (CERN European Organization for Nuclear Research) 20261Sporadic storiform collagenoma of the oral mucosa: a case series and literature reviewSibele Nascimento de AQUINO; Lucas Lacerda de SOUZA; Alan Roger SANTOS-SILVA; Marcio Ajudarte LOPES; Pablo Agustin VARGAS; Leticia Ferreira Cabido

Series (stratigraphy); MEDLINE; Oral cavity; Medicine; Dermatology; Pediatrics

2026-05-07https://doi.org/10.1016/j.oooo.2026.03.013Oral Surgery Oral Medicine Oral Pathology and Oral Radiology 20261Just Transition? Environmental Racism and Wind Energy in BrazilWind energy has expanded rapidly in Brazil in recent years, accounting for 15.2% of national electricity generation in 2023. This growth, however, has been accompanied by socioenvironmental conflicts in communities located near wind farms, including livelihood disruptions, forced displacement, and health impacts. Using national census data and georeferenced information on existing and planned wind farms, we examined the racial composition of census tracts hosting these facilities across six states in Brazil’s Northeast Region, which concentrates 91% of the country’s wind power capacity. Our analysis shows that between 56% and 73% of these census tracts, depending on the state, have proportions of racialized groups (Black, Brown, and Indigenous populations) above their respective municipal averages. These findings underscore the need to improve public participation and community consultation processes for wind energy projects in Brazil in order to mitigate the reproduction of structural racism in the sector.Bruno Milanez; Juliana Siqueira‐Gay

Census; Livelihood; Wind power; Indigenous; Georeference; Racism; NIMBY; Geography; Economic growth; Political science; Socioeconomics; Environmental justice; Order (exchange)

2026-05-07https://doi.org/10.1177/19394071261445833Environmental Justice 20261Dengue e manifestações bucaisObjetivo: Analisar as manifestações bucais associadas a indivíduos com dengue. Métodos: Foram realizadas buscas nas bases de dados Scientific Electronic Library Online (SciELO), National Library of Medicine (NIH/PubMed) e Biblioteca Virtual em Saúde (BVS), entre abril de 2024 e setembro de 2025, por três pesquisadores, utilizando os descritores dengue, oral manifestation e mouth mucosa, combinados com os operadores booleanos AND e OR. Resultados: Foram encontrados 53 estudos nas buscas realizadas nas bases de dados. Após a análise dos títulos, resumos e leitura completa, considerando os critérios de inclusão e exclusão, foram incluídos 8 estudos para a revisão. Considerações finais: A infecção pelo vírus da dengue pode estar associada a diversas manifestações bucais em indivíduos, destacando-se sangramentos espontâneos, petéquias, vesículas, bolhas, placas e crostas hemorrágicas. Alterações menos frequentes, como candidíase pseudomembranosa, papilite lingual transitória e xerostomia, também foram descritas. A identificação dessas manifestações pelo cirurgião-dentista pode contribuir para o diagnóstico precoce da dengue e para a redução da morbidade associada à doença.Thiago Souza Moreira; Ederson Squizato Júnior; Raphael José da Silva Dutra; Jocimara Domiciano Fartes de Almeida Campos; Márcio José da Silva Campos; Ana Carolina Morais Apolônio; Mariana Simões de Oliveira; Fernanda Ramos de Faria

Dengue fever; Computed tomography; Disease; Medicine; Humanities

2026-05-07https://doi.org/10.25248/reas.e23404.2026Revista Eletrônica Acervo Saúde 20261Differential lethal action of octyl and oct-4E-enyl p-nitrobenzoates in Leishmania spp. – a mechanistic studyLeishmaniasis is a neglected tropical disease caused by protozoan parasites of the genus Leishmania . Current treatments, mainly based on pentavalent antimonials and amphotericin B, are limited by severe side effects, high costs, and the emergence of resistant strains, highlighting the need for new therapeutic scaffolds. Gibbilimbol B, an alkylphenol derivative isolated from the Brazilian plant Piper malacophyllum , has shown antileishmanial potential, prompting the design of analogues to optimize its biological activity. Previous studies have investigated gibbilimbol B–inspired derivatives to enhance potency, selectivity, and ADMET properties. Structural modifications of the phenolic ring and side chain improved potency and drug-like properties, particularly in 4-nitrobenzamide derivatives with C 8 side chains. Therefore, the present study investigates two ester analogues - octyl 4-nitrobenzoate ( 1 ) and oct-4 E -enyl 4-nitrobenzoate ( 2 ), as well as 4-nitrobenzoic acid ( 3 ) - for their in vitro antileishmanial activity against L . infantum , L. amazonensis , and L. braziliensis promastigotes and intracellular amastigotes. Compound 1 , which has a saturated C 8 side chain, exhibited significant activity, with EC 50 values of 5.8 ± 0.2, 13.5 ± 0.2 and 1.0 ± 0.1 μg/mL for promastigotes of L. infantum, L. amazonensis and L. braziliensis , respectively. This compound displayed also reduced cytotoxicity to macrophages in vitro (CC 50 = 201 ± 10 μg/mL) and a high selectivity index (SI > 200 for L. braziliensis ). In contrast, compound 2 , featuring a double bond at the C-4 position of a C 8 side chain, exhibited moderate activity. Meanwhile, compound 3 , the original benzoic acid derivative, was inactive. Mechanistic assays with compound 1 revealed mitochondrial depolarization and reactive oxygen species (ROS) generation without loss of plasma membrane integrity, suggesting an apoptotic-like death pathway. Given its simple structure and promising results, octyl-4-nitrobenzoate ( 1 ) can be considered a promising candidate for further SAR (structure-activity relationship) optimization for the development of new antileishmanial drugs. • Octyl 4-nitrobenzoate ( 1 ) and oct-4 E -enyl 4-nitrobenzoate exhibits selective in vitro activity against Leishmania spp. • Antileihsmanial effect promotes parasite death through mitochondrial dysfunction and ROS generation. • Nitroaromatic ester structure enhances selectivity over host macrophages. • Gibbilimbol-inspired analogues supports development of plant-derived therapies for leishmaniasis.Camila S Freitas; Daniela P. Lage; Breno L. Pimenta; Luciana M. Ribeiro Antinarelli; Elaine S. Coimbra; Larissa V.F. Oliveira; Eduardo A. F. Coelho; Joao Henrique G. Lago

Leishmania; Leishmania braziliensis; Leishmaniasis; Cytotoxicity; Amastigote; In vitro; Protozoa; Mechanism of action; Potency; Intracellular; Chemistry; Biochemistry; Pentamidine; Pharmacology; Trypanosoma cruzi; Leishmania infantum; Stereochemistry; Biology; Side chain; Leishmania mexicana; Amphotericin B; Structure–activity relationship; Mode of action; Kinetoplastida; Derivative (finance); Biological activity; Antiparasitic

2026-05-07https://doi.org/10.1016/j.cbi.2026.112132Chemico-Biological Interactions 20261Características dos atendimentos do Serviço de Atendimento Móvel de Urgência: uma ênfase na atenção primária e nas redes de atenção à saúdeObjetivo: Caracterizar as demandas atendidas pelo Serviço Regional de Atendimento Móvel de Urgência-Consórcio Intermunicipal de Saúde Sudeste (SAMU/CISDESTE) no município de Juiz de Fora/MG buscando identificar o funcionamento efetivo da Rede de Atenção às Urgências e Emergências do município, especialmente em relação à Atenção Primária à Saúde (APS), entre outubro/2022 e setembro/2023. Métodos: Estudo transversal quantitativo com utilização de dados secundários do Sistema de Informações da Central de Regulação de Urgência do SAMU/CISDESTE. Foram realizadas análises descritivas e o teste q-quadrado (p≤0,05) com auxílio do softwareSPSS. Resultados: Os homens representaram 53,6% da demanda atendida, com associação aos atendimentos traumáticos. Idosos corresponderam 44,1% dos atendimentos. Ocorrências clínicas representaram 64,8%, com associação a mulheres e idosos. Queda da própria altura representou 8,8% da demanda. Embora haja cobertura de unidades básicas de saúde nos bairros de maior demanda, 58,6% dos atendimentos ocorreram fora do horário de funcionamento. 51,02% dos atendimentos foram classificadas como demandas pouco urgentes/não urgentes. O principal desfecho dos atendimentos foi o encaminhamento dos usuários para unidades de saúde de maior complexidade. Conclusão: Parte dos atendimentos do SAMU/CISDESTE seria passível de manejo na APS, evidenciando fragilidades na organização da rede e possível inadequação na utilização dos serviços pela população.Mariana da Fonseca Pereira; Akinori Cardozo Nagato; Estela Márcia Saraiva Campos

Poison control; Social worlds; Chemistry; Humanities

2026-05-07https://doi.org/10.25248/reas.e23557.2026Revista Eletrônica Acervo Saúde 20261Antileishmanial Evaluation and Mechanism of Action of Benzothiazole Derivatives with Aromatic/Heteroaromatic Hydrazone MoietyINTRODUCTION: Treatment of leishmaniasis is limited to a few drugs, with serious side effects and contraindications. Thus, the need for alternatives to treat this neglected infectious disease is undeniable. METHODS: In this work, a series of benzothiazole derivatives was synthesized, and their in vitro effects against promastigotes and intracellular amastigotes of Leishmania spp. and their macrophage toxicity were evaluated. Peritoneal macrophages were successful obtained from BALB/c mice were used for intracellular amastigotes of Leishmania spp. assays and to assess their toxicity on mammalian cells. In vitro studies on the mechanism of action and drug combination assays were also performed. RESULTS: Compound 2a exhibited remarkable activity against L. amazonensis and L. infantum, with IC50 values below 5 μM against amastigote forms (3.96 μM and 4.0 μM, respectively), surpassing the reference drug miltefosine, and had no cytotoxic effect on macrophages (CC50 > 150 μM). DISCUSSION: The antileishmanial effect of compound 2a was associated with hyperpolarization of the mitochondrial membrane potential, increased ROS levels, and the formation of lipid bodies in treated promastigote forms of L. amazonensis, indicating mitochondrial dysfunction and oxidative stress. No disruption of the promastigotes' plasma membrane was observed after treatment with this compound, ruling out necrotic cell death. Interactions between compound 2a and miltefosine exhibited a better effect at the lowest concentration of compound 2a (combination 1:4) in both promastigote and amastigote forms of L. amazonensis. In silico analysis showed promising physicochemical properties for compound 2a. CONCLUSION: Compound 2a displays strong antileishmanial activity against L. amazonensis and L. infantum, demonstrating a broad ability to inhibit the growth of Leishmania species associated with cutaneous and visceral manifestations.Luciana M. Ribeiro Antinarelli; Alessandra C. Pinheiro; Victor Facchinetti; Thatyana R.A. Vasconcelos; Ari Sérgio de Oliveira Lemos; Adolfo Firmino da Silva Neto; Elaine Soares Coimbra; Marcus Vinícius Nora de Souza

Amastigote; Miltefosine; Mechanism of action; Benzothiazole; In vitro; Intracellular; Leishmania; Toxicity; Drug; Chemistry; Pharmacology; Biochemistry; IC50; Cytotoxicity; Drug action; Leishmaniasis; Mitochondrion; Inner mitochondrial membrane; In silico; Leishmania mexicana; Moiety; Structure–activity relationship

2026-05-04https://doi.org/10.2174/0115680266405459251127053423Current Topics in Medicinal Chemistry 20261Analysis of the impact of terrestrial habitats on the evolutionary dynamics in the phylum CiliophoraAbstract Ciliates inhabit a wide range of habitats, including terrestrial environments. However, macroevolutionary studies on the evolution of habitat preferences within the phylum remain scarce. In this study, we inferred a dated phylogeny, which allowed us to map habitats over time, and assess the macroevolutionary dynamics of these ciliates. Our results show that the last common ancestor of Ciliophora exploited an environment similar to that currently classified as marine/brackish, with terrestrial habitats being occupied only later. Furthermore, we identified two possible evolutionary routes for the transition of ciliates to terrestrial environments: (i) via a marine/brackish ancestor and (ii) via a freshwater ancestor. We also estimated a robust phylogenetic signal, indicating that closely related lineages tend to share similar habitat. Macroevolutionary analyses based on BAMM revealed elevated diversification rates in lineages associated with terrestrial habitats. However, model comparison using HiSSE indicated that diversification dynamics are best explained by a character-independent model with multiple hidden rate regimes. This suggests that terrestrial habitat may not be the sole factor associated with the increased diversification rates, and that the evolutionary success of terrestrial ciliates could also be influenced by morphological, physiological, behavioral, or other unmeasured evolutionary factors.Fabíola da Silva Costa; Wellington Luiz Ouverney Júnior; Roberto Júnio Pedroso Dias; Mariana Fonseca Rossi

Habitat; Macroevolution; Diversification (marketing strategy); Phylum; Phylogenetic tree; Phylogenetics; Evolutionary dynamics; Range (aeronautics); Most recent common ancestor; Biology; Ecology; Evolutionary biology; Marine habitats; Phylogenetic comparative methods; Molecular clock; Evolutionary ecology; Ancestor; Biological evolution; Cladogenesis; Terrestrial ecosystem; Taxonomic rank

2026-04-15https://doi.org/10.1093/biolinnean/blag023Biological Journal of the Linnean Society 20261Comparison of aldehyde and ethanol fixatives in urogenital tissue histology.BACKGROUND: Formaldehyde remains widely used as a fixative despite its documented risks. Ethanol-based fixatives have emerged as safer alternatives, but their performance in urogenital tissues has not been systematically assessed. OBJECTIVE: To compare the histomorphological preservation of rat kidneys, prostate, penis, and testis fixed with ethanol versus formaldehyde-based solutions. METHODS: <0.05). RESULTS: Ethanol-based fixatives (UE and BE) consistently outperformed aldehyde-based fixatives (BF and BP). In kidneys, UE and BE yielded fewer artifacts and superior preservation of glomerular and tubular structures. In the prostate, these fixatives provided better epithelial and stromal quality and fewer artifacts. All fixatives adequately preserved penile cavernous tissue, but BE showed superior urothelial integrity. Following Bouin's pre-fixation, UE and BE improved staining and preservation of the germinal epithelium and Sertoli cells compared with aldehyde fixatives. CONCLUSION: Ethanol-based fixatives provide superior or comparable histomorphological preservation of urogenital tissues while avoiding the health and environmental risks associated with formaldehyde.Bianca Martins Gregório; Carolinne R Macedo; Bruna Romana-Souza; Vinícius Novaes Rocha; Elan C Paes-de-Almeida; Waldemar S. Costa; Diogo Benchimol de Souza; Francisco J Sampaio

Fixative; Genitourinary system; Fixation (population genetics); Epithelium; Staining; Germinal epithelium; Chemistry; Pathology; Ethanol; Glutaraldehyde

2026-05-07https://pubmed.ncbi.nlm.nih.gov/42095435PubMed 20261From Early Descriptions to Modern Imaging: The Evolving Understanding of PapilledemaPapilledema has long been recognised as a cardinal sign of elevated intracranial pressure, yet its structural underpinnings and dynamic behaviour have only recently become accessible through modern ocular imaging. This review traces the historical development of papilledema understanding, from early anatomical descriptions and the introduction of the ophthalmoscope to contemporary high-resolution imaging, and synthesises current evidence on the structural deformation of the optic nerve head in intracranial hypertension. Particular emphasis is placed on anterior displacement of the optic disc, a parameter that complements peripapillary retinal nerve fibre layer thickness assessment and offers unique insight into pressure-related biomechanics. We summarise key studies evaluating optic disc morphology across different aetiologies, treatment modalities, and time courses, highlighting the emergence of deformation of the optic nerve head patterns and their potential diagnostic and prognostic relevance. By integrating historical context, methodological advances, and contemporary evidence, this review outlines how structural imaging has reshaped current understanding and may further refine clinical assessment of papilledema.Gabriel Castilho Sandoval Barbosa; Mário Luiz Ribeiro Monteiro; Leonardo Provetti Cunha

Papilledema; Feature (linguistics); Handwriting; Key (lock); History; Linguistics; Computer science; Artificial intelligence

2026-05-08https://doi.org/10.1080/01658107.2026.2670442Neuro-Ophthalmology 20261AVALIAÇÃO INTERNA DA TEORIA DE MÉDIO ALCANCE PARA ENFERMAGEM EM REABILITAÇÃO CARDIOVASCULARRESUMO Objetivo: Descrever o processo de avaliação dos elementos internos da Teoria de Médio Alcance para Enfermagem em Reabilitação Cardiovascular. Método: Estudo metodológico com avaliação teórica conduzido por método Delphi de consenso, com aplicação de critérios sistemáticos de avaliação de fundamentos substantivos, integridade estrutural e adequação funcional. O julgamento dos especialistas foi quantificado pelo Coeficiente de Validade de Conteúdo, com interpretação descritiva dos resultados. Resultados: Os onze analistas da teoria (5 peritos, 4 proficientes e 2 competentes), a maioria doutores das Regiões Nordeste e Sudeste do Brasil, produziram juízo que indicou o valor do Coeficiente de Validade de Conteúdo geral da teoria considerado bom (CVCt=0,82); sendo ainda excelente os fundamentos substantivos (CVC médio=0,95), boa a integridade estrutural (CVC médio=0,86) e deficiente a adequação funcional (CVC médio=0,66). Conclusão: A avaliação da Teoria de Médio Alcance para Enfermagem em Reabilitação Cardiovascular aponta para validade interna pelos fundamentos substantivos e integridade estrutural, o que suporta a ancoragem na disciplina da enfermagem, clareza e lógica na organização dos conceitos. A adequação funcional, considerada deficiente, é compatível com o atual estado de translação da teoria na prática e pesquisa, sendo critério que reforça a qualidade e o rigor da análise realizada pelos juízes.Maria Sinara Farias; Lúcia de Fátima da Silva; Marcos Antônio Gomes Brandão; Renan Alves Silva; Manuela Gomes Campos Borel; Rosane Barreto Cardoso; Karla Sofía Gómez Alcántara

Nursing care; Term (time); Measure (data warehouse); Quality (philosophy); Humanities; Philosophy; Medicine

2026-01-01https://doi.org/10.1590/1980-265x-tce-2025-0132ptTexto & Contexto - Enfermagem 20261THE INFLUENCE OF THE INFODEMIC ON OLDER ADULTS’ INFORMATION BEHAVIOR: A MULTICENTER ANALYSIS IN BRAZILABSTRACT Objective: To understand older adults’ health information behavior in during an infodemic. Method: This is a multiple case study, using a qualitative approach, anchored in the conceptual model of information behavior and the Life-Span Theory. Data were collected through online interviews with older adults residing in one of eight intentionally chosen Brazilian cities and from publicly available documents about the COVID-19 pandemic in these municipalities. Data were examined using thematic-categorical content analysis. Results: The findings were organized into three analytical categories. The first revealed that older adults sought reliable information using traditional media (radio, television, and print newspapers), support networks such as family members, and government sources. Given cognitive and emotional limitations and limited familiarity with digital technologies, they combined active and passive searches, demonstrating adaptive information strategies. The second category indicated that older adults analyzed information based on experiences, emotions, and cognitive strategies. Their attitudes ranged from critical and selective to confused, influenced by emotional overload, misinformation, and politicization. Responses were identified that varied from active validation to information avoidance. Finally, the third category showed that older adults used information for self-care decisions, such as isolation and mask use, often guided by reliable sources and already established routines. Emotions and the desire for security also guided its use, not always accompanied by critical analysis. Conclusion: Older adults’ information behavior during an infodemic was marked by vulnerabilities, adaptations, and inequalities in access to and use of information.Regina Consolação dos Santos; Edna Aparecida Barbosa de Casto; Sofía Sabina Lavado Huarcaya; Mónica de Melo Freitas; Denise Rocha Raimundo Leone; Ricardo Bezerra Cavalcante

Cognition; Government (linguistics); Isolation (microbiology); Qualitative research; Content analysis; Pandemic; Qualitative analysis; Information seeking; Psychology; Gerontology; Social psychology; Applied psychology; Older people; Public health; Qualitative property; Information behavior

2026-01-01https://doi.org/10.1590/1980-265x-tce-2025-0146enTexto & Contexto - Enfermagem 20261CONSTRUCTION AND VALIDATION OF CHECKLIST FOR SAFE MANAGEMENT OF PERIPHERAL INTRAVENOUS CATHETERS IN OUTPATIENT ANTINEOPLASTIC THERAPYABSTRACT Objective: To develop and validate a checklist for the implementation of good practices related to the safe management of peripheral intravenous catheters in antineoplastic therapy, performed by nurses at an outpatient level. Method: This is a descriptive study with a methodological approach, developed in three stages between August and December 2023: scope review, instrument development, and validation of psychometric properties. Eight expert judges were included to validate the content, and subsequently, 49 nurses performed the validation as the target audience. For data analysis, the Content Validity Coefficient, the Kaiser-Meyer-Olkin and Bartlett's Sphericity tests were used to verify sampling adequacy, followed by Exploratory Factor Analysis and the assessment of internal consistency using McDonald's Omega and Cronbach's Alpha coefficients. Results: The conceptual framework underpinning the construction of the checklist was established through a scoping review that included 16 publications. The content validity coefficient was 0.99, with 12 eigenvalues greater than one identified. Six factors were found to account for 42.6 % of the total variance. The checklist, initially composed of 59 items, was completed with 37, and proved to be reliable, with results of 0.70 for the McDonald Omega test and 0.79 in Cronbach's Alpha. Conclusion: The checklist proved to be valid and reliable for use in the implementation of good nursing practices related to peripheral intravenous catheterization for outpatient antineoplastic therapy.Vanessa Albuquerque Alvim de Paula; Kelli Borges dos Santos; Luciane Ribeiro; Angélica da Conceição Oliveira Coelho; Fábio da Costa Carbogim; André Luiz Silva Alvim

Checklist; Content validity; Cronbach's alpha; Internal consistency; Reliability (semiconductor); Outpatient clinic; Scope (computer science); Validity; Medicine; Intensive care medicine; Nursing; Emergency medicine; Medical emergency

2026-01-01https://doi.org/10.1590/1980-265x-tce-2025-0060enTexto & Contexto - Enfermagem 20261CONSTRUÇÃO E VALIDAÇÃO DE CHECKLIST PARA MANEJO SEGURO DO CATETER INTRAVENOSO PERIFÉRICO NA TERAPIA ANTINEOPLÁSICA AMBULATORIALRESUMO Objetivo: construir e validar um checklist para a implementação de boas práticas relacionadas ao manejo seguro do cateter intravenoso periférico na terapia antineoplásica, realizada pelo enfermeiro em nível ambulatorial. Método: trata-se de um estudo descritivo, de abordagem metodológica, desenvolvido em três etapas entre agosto e dezembro de 2023: revisão de escopo, construção do instrumento e validação das propriedades psicométricas. Oito juízes especialistas foram incluídos para validar o conteúdo, e posteriormente, 49 enfermeiros realizaram a validação como público-alvo. Para a análise dos dados, empregaram-se o Coeficiente de Validade de Conteúdo, os testes de Kaiser-Meyer-Olkin e de Esfericidade de Bartlett para verificar a adequação amostral, seguidos da Análise Fatorial Exploratória e da avaliação da consistência interna por meio dos coeficientes Ômega de McDonald e Alfa de Cronbach. Resultados: a estrutura conceitual que fundamentou a construção do checklist foi estabelecida por meio de uma revisão de escopo que incluiu 16 publicações. O coeficiente de validade de conteúdo foi de 0,99, sendo identificados 12 autovalores acima de um. Foram encontrados seis fatores responsáveis por explicar 42,6 % da variância total. O checklist, inicialmente composto por 59 itens, foi finalizado com 37, e demonstrou-se confiável, com resultados de 0,70 para o teste Ômega de McDonald e 0,79 no Alfa de Cronbach. Conclusão: o checklist mostrou-se válido e confiável para ser utilizado na implementação de boas práticas de enfermagem relacionadas ao cateterismo intravenoso periférico para terapia antineoplásica ambulatorial.Vanessa Albuquerque Alvim de Paula; Kelli Borges dos Santos; Luciane Ribeiro; Angélica da Conceição Oliveira Coelho; Fábio da Costa Carbogim; André Luiz Silva Alvim

Checklist; Ambulatory; MEDLINE; Nursing staff; Continuing education; Medicine; Gynecology

2026-01-01https://doi.org/10.1590/1980-265x-tce-2025-0060ptTexto & Contexto - Enfermagem 20261Asymptomatic Versus Symptomatic Alzheimer's Disease Neuropathology: A Systematic Review of Differences Reported in Post‐Mortem StudiesA subset of individuals exhibit substantial Alzheimer's disease (AD) neuropathology but remain asymptomatic (ASYMAD). The biological processes underlying this phenomenon remain poorly understood. We searched the PubMed/MEDLINE, Web of Science and CAPES databases to synthesise post-mortem brain tissue findings that differ between symptomatic and asymptomatic AD. Thirty-four studies met the predefined eligibility criteria. Multiple reports described lower levels of oligomeric Aβ and p-tau in ASYMAD, with reduced accumulation at synapses. Consistent with synaptic resilience, ASYMAD showed preserved expression of markers and proteomic signatures linked to synaptic function, homeostasis and plasticity. Further analyses supported preserved parenchymal architecture and dendritic and axonal morphology in ASYMAD. Some authors also described compensatory adaptations, including neuronal hypertrophy, increased neurogenesis and cellular antioxidant responses in ASYMAD brains. Additional findings indicated partial resistance to disruption of brain glucose, polyunsaturated fatty acid and one-carbon/polyamine metabolism. Glial and immune findings suggested a profile characterised by increased glial reactivity in specific regions and disease stages, alongside preserved glial homeostasis and lower cytokine expression in other contexts. In conclusion, although this review identified multiple processes potentially associated with the ASYMAD phenotype, the current evidence remains largely descriptive. Additionally, this synthesis is limited by substantial methodological heterogeneity and inconsistencies in data reporting. Future research should prioritise standardised clinicopathological definitions, pathology stage matching between ASYMAD and symptomatic AD groups, systematic assessment of mixed pathologies and further replication of exploratory findings to better elucidate the mechanisms underlying clinical resilience to AD neuropathology.Thiago Guilherme Rêgo Barros; L. Grossi; Maria Letícia da Silva Campos; Israel Bem-Hur Netto Cardoso; Antônio Lúcio Teixeira; Aline Silva de Miranda; Eliana Cristina de Brito Toscano

Asymptomatic; Neuropathology; Disease; Neurogenesis; Homeostasis; Neuroinflammation; Microglia; Multiple sclerosis; Neuroscience; Biology; Pathology; Medicine; Bioinformatics; Biomarker; Atrophy; Neurology; Oligodendrocyte

2026-05-08https://doi.org/10.1111/nan.70077Neuropathology and Applied Neurobiology 20261A INFLUÊNCIA DA INFODEMIA NO COMPORTAMENTO INFORMACIONAL DE IDOSOS: ANÁLISE MULTICÊNTRICA NO BRASILRESUMO Objetivo: compreender o comportamento informacional em saúde de pessoas idosas no contexto de uma infodemia. Método: estudo de casos múltiplos, de abordagem qualitativa, ancorado no modelo conceitual de comportamento informacional e na Teoria do Desenvolvimento ao Longo da Vida.Coleta de dados: entrevistas online com pessoas idosas, que residiam em uma das oito cidades brasileiras escolhidas intencionalmente; em documentos tornados públicos sobre a pandemia de Covid-19 nesses municípios. Os dados foram examinados por meio de Análise de Conteúdo Temático-Categorial. Resultados: os achados foram organizados em três categorias analíticas. A primeira revelou que pessoas idosas buscaram informações confiáveis, recorrendo a mídias tradicionais (rádio, televisão e jornais impressos), redes de apoio - como familiares - e fontes governamentais. Diante de limitações cognitivas e emocionais e da pouca familiaridade com tecnologias digitais, combinaram buscas ativas e passivas, mostrando-se adaptativas em suas estratégias informacionais. A segunda categoria indicou que idosos analisaram informações com base em experiências, emoções e estratégias cognitivas; as posturas oscilaram entre crítica, seletiva e confusa, influenciadas por sobrecarga emocional, desinformação e politização. Identificaram-se respostas que variaram da validação ativa à evitação informacional. Por fim, a terceira categoria evidenciou que pessoas idosas utilizaram informações para decisões de autocuidado, como isolamento e uso de máscaras, frequentemente orientadas por fontes confiáveis e rotinas já consolidadas; emoções e desejo de segurança também direcionaram o uso, nem sempre acompanhados de análise crítica. Conclusão: o comportamento informacional de pessoas idosas durante a infodemia foi marcado por vulnerabilidades, adaptações e desigualdades no acesso e no uso da informação.Regina Consolação dos Santos; Edna Aparecida Barbosa de Casto; Sofía Sabina Lavado Huarcaya; Mónica de Melo Freitas; Denise Rocha Raimundo Leone; Ricardo Bezerra Cavalcante

Context (archaeology); Humanities; Psychology; Sociology; Philosophy

2026-01-01https://doi.org/10.1590/1980-265x-tce-2025-0146ptTexto & Contexto - Enfermagem 20261POLÍTICAS PÚBLICAS, EXTENSÃO UNIVERSITÁRIA E EMPREENDIMENTOS ECONÔMICOS SOLIDÁRIOS DE RECICLAGEMEste artigo discute o papel da extensão universitária junto a Empreendimentos Econômicos Solidários (EESs) de reciclagem e direcionados para a implementação de Políticas Públicas (PPs) de gerenciamento de resíduos sólidos. Para tanto, se utilizou da metodologia pautada no tipo de pesquisa de estudo de caso com observação participante e adotou como amostra os EES(s) atendidos pelo Programa Ambiente-se, em três situações, com características e de localidades diferentes. Realizamos a descrição de dois casos que selecionamos para serem objeto de reflexão nesse artigo e correlacionamos eles ao conceito de extensão. Os instrumentos jurídicos aqui analisados têm a capacidade de serem replicados em outras instituições que realizam este tipo de trabalho extensionista com EES(s) constituídos por catadoras e catadores. Objetiva refletir sobre as atividades de extensão e suas contribuições para docentes e discentes de Cursos de graduação e pós-graduação em Direito no Brasil. Por fim, problematiza a assistência jurídica gratuita, as principais formas de atendimento e suas consequências para a democratização do acesso à justiça.Fernanda Henrique Cupertino Alcântara; Rosana Ribeiro Felisberto; Jamir Calili Ribeiro

Work (physics); Field (mathematics); Order (exchange); Normative; Government (linguistics); Political science; Humanities; Sociology

2026-05-07https://doi.org/10.5212/rev.conexao.v.22.25904.009Revista Conexao UEPG 20261Integration of Deep-Learning and Species Distribution Models for Classification of Animal Species of the Brazilian FaunaThe automated classification of animals from photos is important in ecology and conservation biology for organizing and understanding the immense diversity of species, as well as facilitating effective conservation and management practices. It is equally important for disease surveillance systems, allowing prompt detection of anomalies in species distributions and boosting citizen-scientist platforms by making user-reported data more accurate and convenient. Image classification uses photos and can also rely on the geographical locations of animals to improve performance. While image classification models have difficulties in classifying low-quality images, unbalanced datasets, and with a small number of images, species distribution models have difficulty in classifying species that coexist in a given region. We propose here strategies for combining image classification models based on deep neural networks with species distribution models using genetic algorithms. The proposal is applied to a real-world dataset comprising fifteen classes of animals from the Brazilian fauna obtained from Fiocruz's citizen-scientist Wildlife Health Information System (SISS-Geo). The SISS-Geo photos portray the reality of animals in their environments, with varying quality, and pose numerous difficulties for classification. Experimental results demonstrate that the proposed integration consistently outperforms standalone models. While individual SDMs achieve Top-1 accuracies of 27.79% (MaxEnt) and 31.76% (Bioclim), and CNN-based classifiers reach 58.17% with ResNet50 and 64.13% with ResNet-152, the hybrid strategies yield substantial improvements. The genetic algorithm-based integration with a single global weight achieves up to 67.96% Top-1 accuracy, whereas the class-specific integration using fifteen parameters attains the best overall performance, reaching 69.03%.Mateus Braga Oliveira; Heder S. Bernardino; Alex Borges Vieira; Antônio Arbex Barroso; Douglas A. Augusto

Fauna; Boosting (machine learning); Distribution (mathematics); Species distribution; Data integration; Wildlife; Environmental niche modelling; Pattern recognition (psychology); Artificial intelligence; Ecology; Machine learning; Computer science; Geography; Animal species; Data mining; Species diversity; Contextual image classification

2026-05-08https://doi.org/10.64898/2026.05.06.723365bioRxiv (Cold Spring Harbor Laboratory) 20261EVALUATION OF THE INTERNAL ELEMENTS OF MIDDLE-RANGE THEORY FOR NURSING IN CARDIOVASCULAR REHABILITATIONABSTRACT Objective: To describe the process of evaluating the internal elements of the Middle-Range Theory for Nursing in Cardiovascular Rehabilitation. Method: Methodological study with theoretical evaluation conducted through the Delphi consensus method, with the application of systematic criteria for evaluating substantive foundations, structural integrity, and functional adequacy. The experts' judgment was quantified by the Content Validity Coefficient, with descriptive interpretation of the results. Results: The eleven analysts of the theory (5 experts, 4 proficient, and 2 competent ones), most of them PhDs from the Northeast and Southeast regions of Brazil, judged indicating that the value of the general Content Validity Coefficient of the theory was considered good (CVCt=0.82); the substantive foundations were excellent (average CVC=0.95); the structural integrity was good (average CVC=0.86); and the functional adequacy was deficient (average CVC=0.66). Conclusion: The evaluation of the Middle-Range Theory for Nursing in Cardiovascular Rehabilitation points to internal validity based on its substantive foundations and structural integrity, which support anchoring in the nursing course, clarity and logic in the organization of concepts. Functional adequacy, considered deficient, is consistent with the current state of translation of theory into practice and research, being a criterion that emphasizes the quality and rigor of the analysis carried out by the judges.Maria Sinara Farias; Lúcia de Fátima da Silva; Marcos Antônio Gomes Brandão; Renan Alves Silva; Manuela Gomes Campos Borel; Rosane Barreto Cardoso; Karla Sofía Gómez Alcántara

CLARITY; Delphi method; Nursing theory; Rehabilitation; Internal validity; Process (computing); Meaning (existential); Content validity; Psychology; Nursing; Medicine; Quality (philosophy); Empirical research; Development theory; Construct validity; Item response theory; Applied psychology

2026-01-01https://doi.org/10.1590/1980-265x-tce-2025-0132enTexto & Contexto - Enfermagem 20261FORÇAS DE CARÁTER E SATISFAÇÃO COM A VIDA: UMA REVISÃO INTEGRATIVA DA LITERATURAAs forças de caráter têm sido progressivamente reconhecidas como disposições psicológicas positivas associadas ao desenvolvimento humano saudável, à adaptação emocional e à promoção do bem-estar. No campo da Psicologia Positiva, esse construto ganhou destaque por permitir uma compreensão mais abrangente das potencialidades humanas, ultrapassando modelos centrados exclusivamente em déficits, sintomas e adoecimento. O presente estudo teve como objetivo analisar, na literatura científica, a relação entre forças de caráter e satisfação com a vida, identificando os principais achados empíricos, os contextos de investigação e as implicações psicológicas desse vínculo. Trata-se de uma revisão integrativa de literatura, desenvolvida a partir das etapas propostas por Mendes, Silveira e Galvão, com buscas realizadas nas bases SciELO, PePSIC, Biblioteca Virtual em Saúde e Portal de Periódicos CAPES. Foram adotados critérios de inclusão relacionados à pertinência temática, disponibilidade do texto completo, recorte temporal e aderência ao problema de pesquisa. Os estudos analisados indicam, de modo consistente, associação positiva entre forças de caráter e indicadores de bem-estar subjetivo, bem-estar psicológico, autorregulação emocional, projeto de vida e funcionamento adaptativo. Entre as forças mais frequentemente relacionadas à satisfação com a vida e ao florescimento destacam-se esperança, gratidão, amor, vitalidade, curiosidade, perdão, prudência e autorregulação. Conclui-se que o investimento no reconhecimento e desenvolvimento das forças de caráter representa estratégia relevante para a promoção da saúde mental, da qualidade de vida e do desenvolvimento integral em diferentes grupos populacionais.Cristianne Maria Nolêto Pontes; Danielle Ferreira Silva; DAFNE FERNANDA FERNANDES MAIA; Alexandre Marco de Leon; Carlos Magno Oliveira da Silva; Lara Misztela Dos Santos; Marcus Vinicius Días de Oliveira; Gláucia Oliveira Abreu Batista Meireles; Jefferson Amaral de Morais; Juliana Macedo Melo Andrade; Ana Luiza de Paula Aguiar Caetano; Marcus Vinícius Ribeiro Ferreira

Order (exchange); Context (archaeology); State of art; Philosophy; Humanities

2026-05-09https://doi.org/10.70773/revistatopicos/778119983Revista Tópicos. 20261Habitat‐Mediated Filtering, Rather Than Soil Properties, Shapes Plant Community Diversity on Nelson Island, Maritime AntarcticaABSTRACT Aims Environmental filtering is a key framework in vegetation science; yet, disentangling the relative roles of habitat and soil‐mediated filters remains challenging in Antarctic cryptogamic communities. At the regional scale in Antarctica, climate is the primary driver of plant community diversity and structure. However, at a local scale, topography and soil properties are also crucial. This study aimed to assess how habitat‐mediated (including substrate type and nesting‐related disturbance), and soil properties act as environmental filters shaping cryptogamic species richness and community composition on rocky outcrops. We evaluated the relative contribution of habitat structure and edaphic variation to plant distribution across substrate gradients. Location Harmony Point, Nelson Island, Maritime Antarctica. Methods We conducted detailed vegetation and soil surveys across three rocky outcrops with varying nesting activity. Plant frequency, coverage, and richness were quantified in 121 plots using a grid‐based approach. Soil samples were collected and analyzed for physical and chemical properties. To quantify environmental gradients, we summarized edaphic variables using multivariate analysis. Rarefaction/extrapolation curves, community composition analysis, and linear mixed‐effects models were used to test whether habitat‐mediated and soil‐mediated filters predict species richness and community composition variability. Results Habitat‐mediated filtering strongly influenced species richness and turnover. Sites with active giant petrel nests exhibited higher nutrient availability and distinct vegetation assemblages compared to areas without nesting activity. Substrate type also played a key role, with species composition differing markedly between rocky and soil substrates. These patterns indicate that both soil fertility and microhabitat heterogeneity contribute to the spatial variability in community structure. Conclusions Our results further reveal that changes in substrate type across the outcrops promote high species turnover between the three rocky fragments. Contrary to patterns commonly reported for Maritime Antarctica, soil properties alone did not explain richness or composition, suggesting that habitat‐level processes override edaphic constraints at a fine spatial scale.Flávia R. Ferrari; Pedro M. Villa; Jair Putzke; Sharon A. Robinson; Marcio R. Francelino; Carlos E.G.R. Schaefer

Edaphic; Species richness; Plant community; Vegetation (pathology); Habitat; Ruderal species; Soil fertility; Species diversity; Community structure; Ecology; Environmental science; Geography; Substrate (aquarium); Biodiversity; Beta diversity; Microsite; Plant ecology; Community; Indicator species; Spatial heterogeneity

2026-05-01https://doi.org/10.1111/jvs.70145Journal of Vegetation Science 20261Luxo e Moda nos Jogos Digitais Através dos GachasNos últimos tempos o mercado de jogos digitais deu espaço a um novo gigante: os jogos gachas. Os jogos, principalmente os gachas, tem por objetivo criar um espaço fantástico, como um sonho lúcido onde o jogador pode experimentar uma experiencia hedonística, controlada pelas regras do jogo e, nesse espaço, os corpos, que são a representação do jogador por meio do avatar, tem as mesmas demandas do mundo cotidiano, ou seja, sujeitos aos fenômenos da moda e do luxo.Fillipe de Souza Montes

Adventure; Subject (documents); Digital era; Order (exchange); Art; Humanities; Advertising; Aesthetics

2026-05-09https://doi.org/10.5281/zenodo.20093079Zenodo (CERN European Organization for Nuclear Research) 20261Role of Bi2O3 on structural and optical properties of Nd3+ doped boron-tellurite glassesI. T. Lima; F.A. Carvalho; M. Seshadri; R.T. Alves; L.S. Ávila; L.N. Rodrigues; M.J.V. Bell; V. C. do Anjos

Doping; Optical materials; Optical glass; X-ray crystallography; Analytical Chemistry (journal); Materials science; Optoelectronics

2026-05-09https://doi.org/10.1016/j.optmat.2026.118157Optical Materials 20261Beyond Round-Bottom Flasks: Enabling Technologies in Organic Synthesis TeachingHigh Resolution Image Download MS PowerPoint Slide Organic synthesis education has traditionally emphasized classical batch reactions and thermal activation, often with limited exposure to the strategies that currently shape synthetic practice. In contrast, enabling technologies such as continuous-flow chemistry and mechanochemistry and alternative activation methods like electrosynthesis and photocatalysis have expanded the synthetic toolbox by enabling new reactivity patterns and greater control over reaction parameters. Hereby, we discuss the integration of enabling technologies into the teaching of organic synthesis, highlighting their value for strengthening mechanistic reasoning, exploring the relationship between activation modes and chemical reactivity, and promoting active learning. Rather than replacing classical approaches, these technologies are presented as complementary tools that can broaden the conceptual understanding and better connect organic chemistry education with modern synthetic practices.Marcelo H. R. Carvalho; Rodrigo C. Silva; Julio C. Pastre; Giovanni W. Amarante; Pedro P. de Castro

Organic synthesis; Science education; Higher education; Teaching method; Nanotechnology; Computer science; Chemistry; Engineering; Engineering ethics

2026-05-09https://doi.org/10.1021/acs.jchemed.6c00288Journal of Chemical Education 20261Luxo e Moda nos Jogos Digitais Através dos GachasNos últimos tempos o mercado de jogos digitais deu espaço a um novo gigante: os jogos gachas. Os jogos, principalmente os gachas, tem por objetivo criar um espaço fantástico, como um sonho lúcido onde o jogador pode experimentar uma experiencia hedonística, controlada pelas regras do jogo e, nesse espaço, os corpos, que são a representação do jogador por meio do avatar, tem as mesmas demandas do mundo cotidiano, ou seja, sujeitos aos fenômenos da moda e do luxo.Fillipe de Souza Montes

Adventure; Subject (documents); Digital era; Order (exchange); Art; Humanities; Advertising; Aesthetics

2026-05-09https://doi.org/10.5281/zenodo.20093080Zenodo (CERN European Organization for Nuclear Research) 20261The Brazilian dairy industry: Doce de leite chemistry and technologyBackground Doce de leite (DL) is produced through induced heat concentration and its market has been increasing over the past decade, even in countries known for producing it. Brazil ranks in an outstanding position as DL producer and consumer, as well as for holding great technological expertise on it. Therefore, bearing in mind, an overview of the Brazilian DL sector allows broadening and better exploring such an expertise. Aims Providing an analytical summary of DL scientific, technological and commercial aspects often available in scientific publications in this field. The study is also an analysis of these three fields. The analysis was based on the Brazilian DL production and aimed at introducing its heterogeneity in the country. Methods Data collection based on the following meshes: ‘ doce de leite ’ and ‘ dulce de leche ’. The goal was to find information about how diverse and yet unexplored the Brazilian DL market is, as well as about how many studies Brazil has published on this topic. Production, export and import data were assessed to provide a clear view of the Brazilian market. Major Findings Brazil is the second largest DL producer in the world and its industrial sector counts on more than 350 registered manufactures. This product's diversity and the number of publications by Brazilian researchers on this topic lead to the conclusion that the Brazilian DL sector is diverse and still has a huge wind of opportunities to become its largest producer. Industrial Implications Findings have provided a clear view of the Brazilian DL industry's scientific, technological and commercial sectors, and allowed interested readers to better understand this sector in Brazil.Isadora O B Rodrigues; Gabriel P P Cerqueira; Ítalo Tuler Perrone; Alan Frederick Wolfschoon-Pombo; Rodrigo Stephani

Dairy industry; Position (finance); Production (economics); Diversity (politics); Milk production; Industrial production; Business; Agricultural science; Agricultural economics; Marketing; Industrial organization; Regional science

2026-04-01https://doi.org/10.1111/1471-0307.70121International Journal of Dairy Technology 20261Music therapy as a nonpharmacological strategy for anxiety management during third molar surgery: a critical reviewOBJECTIVE: To critically analyze the current evidence regarding the use of music therapy as a nonpharmacological strategy for anxiety management during third molar surgery. STUDY DESIGN: A critical review was conducted based on a structured search in PubMed, Scopus, and Web of Science databases. Studies evaluating music therapy during dental or surgical procedures and reporting outcomes related to anxiety, pain, or physiological parameters were included. RESULTS: A total of 12 studies were included, comprising several hundred patients. Most studies demonstrated that music therapy is associated with reductions in anxiety levels and improvements in physiological parameters such as heart rate and blood pressure. In addition, music exposure was frequently associated with enhanced patient relaxation, improved overall experience, and, in some cases, reduced perception of pain during dental and surgical procedures. CONCLUSION: Music therapy appears to be a promising, low-cost, and noninvasive strategy for anxiety management during third molar surgery, contributing to improved patient experience. Further well-designed clinical studies are needed to strengthen the evidence base.Nathália Duarte Barros Rocha; Márcio Eduardo Vieira Falabella

Music therapy; Anxiety; Molar; MEDLINE; Medicine; Psychotherapist; Clinical psychology

2026-05-01https://doi.org/10.1016/j.oooo.2026.05.004Oral Surgery Oral Medicine Oral Pathology and Oral Radiology 20261Spatially Constrained Copula‐Based Clustering for Climate Zone Classification in BorneoABSTRACT This study presents an advanced climate zone classification approach for Borneo using a spatially constrained copula‐based clustering framework. The methodology integrates copula theory for multivariate dependency modelling with fuzzy c‐means (FCM) clustering to capture uncertainty in regional climate classification, while spatial constraints enhance geographic coherence. Historical climate data from the Princeton Global Forcing dataset (1950–2014) were used, encompassing elevation, rainfall, average temperature (Tavg), minimum temperature (Tmin), maximum temperature (Tmax), diurnal temperature range (DTR) and relative humidity (RH). A total of 23 normalisation methods and 11 distance metrics were evaluated to optimize clustering performance. Clustering sensitivity was assessed using internal validation indices: Average Silhouette Width (ASW), Dunn Index (DI) and Calinski‐Harabasz Index (CHI). Results revealed that Yeo‐Johnson normalisation combined with Minkowski distance yielded the most robust performance (ASW = 0.3720, DI = 1.00EE‐04, CHI = 533.25). This configuration successfully delineated five distinct climate zones, Central‐North, East, West, Northeast and South, by achieving a high spatial coherence score (57.08) and establishing contiguous, topo‐climatologically meaningful regions. Central‐North emerged as the coolest and wettest, with the highest elevation, RH and DTR. East and South zones were the warmest, exhibiting the lowest RH and highest variability in DTR and rainfall. The Northeast showed the most pronounced seasonal and spatial temperature variation, while the West was marked by high rainfall and moderate DTR and RH. These zones reflect Borneo's climatic heterogeneity shaped by topographic and thermal‐hygrometric gradients. Spatial autocorrelation analysis using Moran's I confirmed clear spatial structures within clusters, with rainfall and RH showing the strongest spatial dependencies and Tmax the weakest. The West zone emerged as the most spatially homogeneous, while the South exhibited lower spatial dependence. This study advances regional climate classification by integrating statistical rigour, spatial consistency and multivariate climate behaviour, offering valuable insights for climate impact assessment, ecological planning and adaptive environmental management in tropical regions.Zulfaqar Sa'adi; Ricky Anak Kemarau; Zaher Mundher Yaseen; Najeebullah Khan; Bassim Mohammed Hashim; Leonardo Goliatt; Sajjad Firas Abdulameer; Shamsuddin Shahid

Spatial ecology; Spatial analysis; Cluster analysis; Downscaling; Forcing (mathematics); Spatial coherence; Common spatial pattern; Range (aeronautics); Climate change; Climatology; Environmental science; Climate model; Climate pattern; Spatial variability; Precipitation; Relative humidity; Multivariate statistics; Copula (linguistics); Mean radiant temperature; Spatial distribution

2026-05-10https://doi.org/10.1002/joc.70420International Journal of Climatology 20261Power properties of classical test statistics in Weibull regression models with censoring and their applications to sample size calculationRegression models for time-to-event data are widely used in clinical and reliability studies, particularly in the presence of censoring. In this context, the Weibull regression model provides a flexible alternative to the proportional hazards model, allowing for a fully specified survival function and interpretable measures of treatment effects. However, inference based on classical test statistics may be unreliable in small or moderate samples. In this paper, we derive closed-form approximations for the non-null asymptotic distributions of the likelihood ratio, Wald, score, and gradient tests under Pitman alternatives in Weibull regression models for censored data. These results facilitate analytical evaluation of local power and provide a basis for comparing the performance of the four tests. The proposed approximations are assessed through simulation studies, which highlight their accuracy in moderate-to-large samples and illustrate the impact of censoring and model complexity. An application is presented to the design of Phase Ⅱ clinical trials to demonstrate how derived power functions can be used to estimate sample sizes. The results provide a computationally efficient tool for power analysis in censored Weibull regression models, although their use in practice should be complemented with simulation-based validation in small-sample or high-censoring scenarios.Tiago M. Magalhães; Yolanda M. Gómez; M. R. Diniz; Osvaldo Venegas; Diego I. Gallardo; Departamento de Estadística, Facultad de Ciencias, Universidad del Bío-Bío, Concepción 4081112, Chile; Departamento de Ciencias Matemáticas y Físicas, Facultad de Ingeniería, Universidad Católica de Temuco, Temuco, 4780000, Chile

Censoring (clinical trials); Weibull distribution; Sample size determination; Regression analysis; Statistical hypothesis testing; Linear regression; Regression; Order statistic; Statistics; Mathematics; Econometrics; Power function

2026-01-01https://doi.org/10.3934/math.2026528AIMS Mathematics 20261AI in early oral cancer detection: a systematic review of technologies and clinical impactObjective: To evaluate the effectiveness and clinical applicability of artificial intelligence (AI) in the early diagnosis of oral cancer compared to conventional methods. Material and Methods: This systematic review was prospectively registered in the PROSPERO database under the number CRD420251083609. A descriptive systematic review was conducted based on the PICO question: “In patients with suspected oral cancer, is AI more effective than traditional methods for early diagnosis?” Searches were performed between April and June 2025 in PubMed, LILACS, SciELO, Scopus, Web of Science, Embase, and Google Scholar using the keywords “artificial intelligence,” “oral neoplasm,” and “early diagnosis.” Comparative studies reporting diagnostic metrics such as sensitivity, specificity, and accuracy were included. Methodological quality was assessed using the Quality Assessment of Diagnostic Accuracy Studies – Artificial Intelligence extension (QUADAS-AI) and the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) system. Results: Of 1,704 identified studies, 12 met eligibility criteria. Most studies employed retrospective observational designs, primarily using convolutional neural networks (CNNs) or hybrid models on clinical and histopathological images. Reported diagnostic accuracy was generally above 80%, and some lightweight models demonstrated potential for remote screening. Common limitations included lack of external validation, methodological heterogeneity, and dependence on image quality. Conclusion: AI shows promising potential to support early diagnosis of oral cancer, improving diagnostic speed and accuracy. Broader clinical implementation will require multicenter validation, standardized datasets, and integration with clinical and histopathological evaluation. KEYWORDS Artificial Intelligence; Computer-aided diagnosis; Early diagnosis; Mouth neoplasms; Squamous Cell Carcinoma of Head and Neck.Luigi de Almeida Albertoni; Letícia dos Santos Sales Martins; Cecília Helpes Rodrigues; Lara Castor Cunha; Henrique Souza Magalhães; Bruno Alves Ferreira; Livia Garcia Resende; Quézia Soares de Paula; Maria Clara Fernandes Ribeiro Dantas; Gisele Maria Campos Fabri

Grading (engineering); Observational study; MEDLINE; Diagnostic accuracy; Systematic review; Basal cell; Cancer; Retrospective cohort study; Medicine; Medical physics; Artificial intelligence; Intensive care medicine; Clinical Practice

2026-01-01https://doi.org/10.4322/bds.2026.e5017Brazilian Dental Science 20261Replication Package for "Solar Resource Exposure to Curtailment: Evidence from Constrained Photovoltaic Plants in Brazil"This repository contains the data and code used in the paper “Solar Resource Exposure to Curtailment: Evidence from Constrained Photovoltaic Plants in Brazil.” The archive includes R scripts for the spatial and plant-level analysis of photovoltaic curtailment in Brazil, based on operational records from the Brazilian system operator, and Python scripts for the localized solar-resource forecasting exercise. The forecasting workflow uses NASA POWER meteorological data at selected photovoltaic plant coordinates, constructs transformed and lagged predictors, estimates rolling-window machine-learning models, and computes individual and grouped permutation-importance measures. The repository also includes raw and processed data files, model outputs, figures, and tables used to support the empirical analysis. A README file documents the folder structure, software requirements, execution order, and the role of each dataset and script.Rafael Morais de Souza; Victor Eduardo de Mello Valério; Felipe de Souza Oliveira; Douglas Silveira

Photovoltaic system; Scripting language; Workflow; Python (programming language); Software; Replication (statistics); Resource (disambiguation); Computer science; Database; Data mining; Software package; Raw data; R package

2026-05-11https://doi.org/10.5281/zenodo.20126649Zenodo (CERN European Organization for Nuclear Research) 20261Autistic Camouflage: Dataset from Brazilian Adults (CAT‑Q Scores and Communication Strategies)Mixed‑methods dataset on social camouflaging among Brazilian adults, including CAT‑Q scores, demographic information, and qualitative free‑text descriptions of communication strategies. Contains data from 49 participants and forms part to a larger international cohort (N = 335). Collected anonymously to minimise bureaucratic and translation‑related barriers.Icaro Abreu; Larissa Laurentino; Grace Ferreira

Cohort; Data collection; Cohort study; Qualitative research; Autism; Psychology; Developmental psychology; Qualitative property

2026-05-11https://doi.org/10.5281/zenodo.20119798Zenodo (CERN European Organization for Nuclear Research) 20261Three-Dimensional Liver Reconstruction in Surgical Planning: A Pictorial EssayLuisa Faria

MEDLINE; Resection; Feature (linguistics); Object (grammar); Medicine; Radiology; Surgery; General surgery

2026-03-12https://doi.org/10.26044/ecr2026/c-16294European Society of Radiology 20261Replication Package for "Solar Resource Exposure to Curtailment: Evidence from Constrained Photovoltaic Plants in Brazil"This repository contains the data and code used in the paper “Solar Resource Exposure to Curtailment: Evidence from Constrained Photovoltaic Plants in Brazil.” The archive includes R scripts for the spatial and plant-level analysis of photovoltaic curtailment in Brazil, based on operational records from the Brazilian system operator, and Python scripts for the localized solar-resource forecasting exercise. The forecasting workflow uses NASA POWER meteorological data at selected photovoltaic plant coordinates, constructs transformed and lagged predictors, estimates rolling-window machine-learning models, and computes individual and grouped permutation-importance measures. The repository also includes raw and processed data files, model outputs, figures, and tables used to support the empirical analysis. A README file documents the folder structure, software requirements, execution order, and the role of each dataset and script.Rafael Morais de Souza; Victor Eduardo de Mello Valério; Felipe de Souza Oliveira; Douglas Silveira

2026-05-11https://doi.org/10.5281/zenodo.20126650Zenodo (CERN European Organization for Nuclear Research) 20261Autistic Camouflage: Dataset from Brazilian Adults (CAT‑Q Scores and Communication Strategies)Mixed‑methods dataset on social camouflaging among Brazilian adults, including CAT‑Q scores, demographic information, and qualitative free‑text descriptions of communication strategies. Contains data from 49 participants and forms part to a larger international cohort (N = 335). Collected anonymously to minimise bureaucratic and translation‑related barriers.Icaro Abreu; Larissa Laurentino; Grace Ferreira

Cohort; Data collection; Cohort study; Qualitative research; Autism; Psychology; Developmental psychology; Qualitative property

2026-05-11https://doi.org/10.5281/zenodo.20119797Zenodo (CERN European Organization for Nuclear Research) 20261Structural Analysis of Flexible Pavements with HMA Exposed to Short-Term AgingThis study presents a comparative evaluation of the structural performance of flexible pavements made from different hot mix asphalt (HMA). HMAs were proportioned using the conventional Marshall method and HMAs subjected to short-term aging were analyzed. Grades B (binder course) and C (surface course), according to DNIT specifications, were used. After determining the aggregate gradation and asphalt content using the Marshall method, test specimens were produced and tested in the laboratory to determine the mechanical parameters characteristic of each HMA (stability, tensile strength by diametral compression, resilient modulus, fatigue behavior, and permanent strain). The Elsym5 software was used to carry out a structural analysis of an assumed pavement, whereby only the mechanical properties of the surface course and the binder course were varied. The results showed that short-term aging significantly affected the mechanical behavior of HMA and the structural response of flexible pavements. Better structural performance was observed in HMAs subjected to short-term aging. The aged specimens showed an improvement in mechanical properties compared to specimens produced by the conventional method, indicating a promising approach for optimizing pavement performance. These results provided new parameters for investigation and development in the field of road engineering.Taciano Oliveira da Silva; Klaus Henrique de Paula Rodrigues; Heraldo Nunes Pitanga; Francisco Aureliano Rocha de Vasconcelos Teixeira; Kelbia da Silva Santos; Paulo Roberto Borges; Gustavo Henrique Nalon; Karine De Oliveira Santos

Gradation; Asphalt; Ultimate tensile strength; Asphalt pavement; Aggregate (composite); Size effect on structural strength; Rut; Structural engineering; Materials science; Composite material; Geotechnical engineering; Forensic engineering

2026-05-09https://doi.org/10.3390/infrastructures11050166Infrastructures 20261Thermostatistical analysis and negative heat capacities of Yukawa and Lee–Wick potentials in noncommutative phase spacesIn recent years, physical models based on noncommutative algebras have attracted considerable interest, as they provide a natural framework to incorporate a fundamental scale, often associated with semiclassical aspects of quantum gravity. Noncommutative geometry modifies the underlying phase-space structure, potentially leading to new insights into unresolved problems in theoretical physics. In this work, we adopt a semiclassical approach to perform a thermostatistical analysis of well-established interaction models, namely, the Yukawa and Lee–Wick potentials, within a noncommutative phase space. We investigate how phase-space deformations affect the density of states, partition function, mean energy and heat capacity, considering both microcanonical and canonical ensembles within the Boltzmann–Gibbs framework. Our results show that the introduction of the noncommutative parameter [Formula: see text] induces nontrivial modifications in thermodynamic quantities, including qualitative changes in the heat capacity. In particular, regions with negative heat capacity may emerge, which we interpret as signatures of the limitations of the semiclassical and perturbative treatment rather than definitive physical effects. The analysis is carried out under the assumption of weak noncommutativity and [Formula: see text], which constrains the regime of validity of the results. Within this domain, our findings highlight the role of phase-space geometry in shaping thermodynamic behavior.Maria João Sousa; Éverton M. C. Abreu; Albert C. R. Mendes; M. J. Neves

Noncommutative geometry; Semiclassical physics; Yukawa potential; Noncommutative quantum field theory; Quantum; Heat capacity; Phase (matter); Physics; Quantum mechanics; Theoretical physics; Partition function (quantum field theory); Classical mechanics; Fermion

2026-05-13https://doi.org/10.1142/s0217751x26501113International Journal of Modern Physics A 20261A plataforma de livros digitais "Minha Biblioteca"Este estudo analisa as percepções dos bibliotecários da lista de discussão da Comissão Brasileira de Bibliotecas universitárias (CBBU) sobre a plataforma “Minha Biblioteca” (MB), com o objetivo de avaliar suas vantagens, desafios e propor diretrizes para sua adoção em instituições de ensino superior. A pesquisa adota abordagem quanti-qualitativa, com revisão bibliográfica, análise documental e aplicação de questionário. Os resultados destacam usabilidade e conteúdo como pontos fortes, enquanto contratos inflexíveis e altos custos representam entraves. Conclui-se que a MB é uma alternativa relevante, desde que sua implantação ocorra mediante negociação adequada e contrato detalhado, com todas as obrigações claramente explicitadas.Sergio Reis; Nanci Elizabeth Oddone

Context (archaeology); Subject (documents); Data collection; Order (exchange); Humanities; Philosophy

2026-01-09https://doi.org/10.22478/ufpb.1809-4775.2025v21n4.76188Biblionline 20261An Overview of the TV 3.0 Application Coding Layer SpecificationThis article presents the technical specifications resulting from R&D and standardization efforts in the application coding layer of the next generation of the Brazilian Digital Terrestrial Television System (SBTVD), known as TV 3.0 or DTV+. The architecture evolves the Ginga middleware into an application-oriented platform, specifying APIs and definitions that enable personalized experiences, integration with Over-The-Top (OTT) services, new forms of interaction and immersion, enhanced accessibility, and audience data collection with privacy safeguards. The initiative is the result of collaboration among the SBTVD Forum, its associated companies, the Ministry of Communications, the National Education and Research Network (RNP), and Brazilian universities.Joel Dos Santos; Li-Chang Shuen Cristina Silva Sousa; Carlos Soares Neto; Guido Lemos; Sérgio Colcher; Marcelo F. Moreno; Débora Muchaluat-Saade

Coding (social sciences); High-definition television; Physical layer; Digital television; Signal processing; Layer (electronics); Decoding methods; Codec; Computer science; Electronic engineering; Telecommunications; Computer network

2026-05-12https://doi.org/10.1109/tbc.2026.3689351IEEE Transactions on Broadcasting 20261FATORES ASSOCIADOS À DEPRESSÃO E À SÍNDROME DE BURNOUT EM PROFISSIONAIS DE SAÚDE DE UNIDADES DE PRONTO ATENDIMENTOObjetivo: Sintetizar o conhecimento científico atual sobre os fatores associados à depressão e à síndrome de burnout em profissionais de saúde atuantes em Unidades de Pronto Atendimento (UPA). Métodos: Revisão integrativa da literatura realizada nas bases PubMed, SciELO, Scopus e BVS, abrangendo o período de 2019 a 2026. Foram selecionados 29 artigos com DOI ativo nos idiomas português, inglês e espanhol, utilizando descritores controlados cruzados com operadores booleanos. Resultados: Observou-se elevada prevalência de exaustão emocional e depressão, associadas à carga horária semanal superior a 60 horas, precariedade dos vínculos empregatícios e isolamento social. Mulheres e profissionais em início de carreira mostraram-se mais vulneráveis. A despersonalização correlacionou-se ao aumento de erros assistenciais, enquanto o suporte social e lideranças participativas atuaram como fatores protetores. Discussão: O ambiente de urgência funciona como gatilho para vulnerabilidades psíquicas, agravado pela fadiga de compaixão e pelo sofrimento ético-político diante da escassez de recursos. Medidas individuais são insuficientes sem reformas estruturais na governança clínica e redução do estigma sobre a saúde mental. Conclusão: O adoecimento mental nas UPAs é um desafio sistêmico que exige a transição da "cultura do heroísmo" para políticas de resiliência organizacional, garantindo a sustentabilidade da força de trabalho e a segurança do paciente.Samuel Cândido Freres; Gabriela Ferreira da Silva; Kamilla Sandrianne Araújo Ferreira; Nicolle Riman; Marina Sales Fiuza; Geraldo de Miranda Neto; Julia de Lima Machado; Sarah Karoline de Oliveira Matos; Pedro Fechine Honorato

Burnout; Occupational burnout; Test (biology); Depersonalization; Humanities; Psychology; Medicine

2026-05-13https://doi.org/10.51891/rease.v12i5.26046Revista Ibero-Americana de Humanidades, Ciências e Educação 20261APLICABILIDADES DA N-ACETILCISTEÍNA NA SAÚDE REPRODUTIVA FEMININA: UMA REVISÃO NARRATIVAN-acetylcysteine is a compound known for its antioxidant properties. Considering its effects on conditions such as endometriosis, polycystic ovary syndrome, infertility, this study aimed to review the applicability of NAC in women's health. To conduct this research, original articles from the literature were examined using the Scientific Electronic Library Online (SciELO), National Library of Medicine (PubMed), and Virtual Health Library (VHL) databases, spanning the period from 2014 to 2024. A total of 28 articles were selected for review. NAC operates through several mechanisms that contribute to its efficacy, the primary one described in the literature being its role as a glutathione precursor. However, other mechanisms have been evaluated, such as its potential to enhance cell viability by inhibiting apoptosis or programmed cell death. Furthermore, it increases the activity of antioxidant enzymes, such as catalase and superoxide dismutase, which results in cellular protection against oxidative damage. The reviewed articles reported that NAC can alleviate pain and reduce the size of endometrial lesions, in addition to potentially enhancing fertility. In PCOS, NAC has demonstrated efficacy in restoring ovulation rates and improving oocyte quality, thereby contributing to higher pregnancy rates. Evidence suggests that NAC may exert a protective role against oxidative stress and inflammation, conditions frequently associated with disorders of the female reproductive system. The described mechanisms and the obtained results render the supplement promising and underscore the necessity of a nutritionist's involvement in its prescription. Its utilization, coupled with a balanced diet and lifestyle, is capable of promoting better outcomes in female reproductive health. Therefore, NAC is described as a favorable intervention, but its clinical application requires further scientific investigation.Clara Oliveira de Vasconcelos; Beatriz Pardal de Matos; Marcela Gemeliano Valverde; Arthur Constantino Dutra da Silva; Larissa Cristina Ramos Laurentino; Natália Oliveira; Clara Mockdece Neves; Ana Paula Boroni MOREIRA

Polycystic ovary; Oxidative stress; Antioxidant; Apoptosis; Reproductive medicine; Catalase; Pregnancy; National library; Medicine; Gynecology; Viability assay; Biology; Oocyte; Ovulation; Reactive oxygen species; Pharmacology; Andrology

2026-05-13https://doi.org/10.66104/b09tb426Revista Multidisciplinar do Nordeste Mineiro 20261The Meaning of Work for Venezuelan Refugees in Brazil: Job Crafting as a Strategy for Inclusion and Professional DevelopmentThe inclusion of refugees in the formal labor markets of host countries has been recognized as a sustainable solution to forced migration. In Brazil, due to the growing number of refugees, it is urgent to look at the difficulties faced by this population and develop strategies for their socio-economic inclusion. This study proposes a reflection on the meaning of decent work for refugees, considering their own perspectives, with the aim of offering a broader understanding of their desires and needs in the labor sphere. A survey was applied to 78 Venezuelan refugees in the northern region of Brazil. The data were analyzed using Jamovi software (Version 2.3.28), including descriptive and inferential statistics. Among the findings were the expectation of opportunities that value the skills of refugees. Difficulties due to cultural adaptation in organizations and a lack of professional recognition were pointed out. Job crafting proved to be a promising strategy for positively shaping work.Renata Avancini Tonini; Mariana Borges Nunes Vieira; Francisco Antonio Coelho Júnior; Maria Caroline Goulart; Iaria Guerra; Aretha Salomão; Pedro Marques-Quinteiro

Refugee; Meaning (existential); Inclusion (mineral); Work (physics); Value (mathematics); Employability; Population; Sociology; Public relations; Sustainable development; Adaptation (eye); Work experience; Psychology; Capability approach

2026-05-13https://doi.org/10.3390/socsci15050315Social Sciences 20261Use of electronic cigarettes among physicians, residents, and medical students in a referral hospital in the state of Amazonas, Brazil: a cross-sectional studyObjective: To determine the prevalence of electronic cigarette use among physicians, residents, and medical students at a university hospital in northern Brazil. Methods: We conducted a cross-sectional observational study using a semi-structured questionnaire to collect data on participants’ knowledge and use of electronic cigarettes. Results: A total of 36 participants were included, most of whom were young female medical students (58.3%) in the 21- to 30-year age bracket. Although 91.7% were aware of electronic cigarettes and their associated health risks, 16 participants reported recreational use of such devices. Conclusions: Despite high awareness of the potential harms of electronic cigarettes, a considerable proportion of participants—primarily young female medical students—continue to use electronic cigarettes recreationally, highlighting the need for targeted educational and preventive strategies among future health care professionals.Luciana Castelo Branco Soares; Luísa Tiemi Souza Tuda; Márcio Luís Lombardi Martinez; Roberta Lins Gonçalves

Referral; Observational study; Electronic cigarette; Health care; Cross-sectional study; Public health; Recreation; Medicine; Family medicine; Medical record

2026-04-28https://doi.org/10.36416/1806-3756/e20250214Respiratory Research & Clinical Practice 20261On the total derivative divergence for a nonminimal vector operatorIn this paper, we report on the calculation of the total derivative [Formula: see text] term in the divergence of the vacuum effective action for the nonminimal vector field operator in a curved space background. This term led to interesting discussions in the literature, in particular because it defines the local part of anomaly-induced effective action in conformal quantum gravity and may be decisive for the renormalizability of this theory. The divergent term of our interest was previously derived several times. One of the main results is that the mentioned local term is gauge-fixing dependent in the case of the electromagnetic field, which contradicts the general theorems about quantum corrections. We perform the derivation by using Riemann’s normal coordinates and confirm the previous results. The discussion includes the possible role of the gauge-dependent IR regulators and the related ambiguity.Thomas M. Sangy; Tibério de Paula Netto; Ilya L. Shapiro

Operator (biology); Divergence (linguistics); Action (physics); Term (time); Conformal map; Quantum; Effective action; Quantum field theory; Quantum gravity; Physics; Mathematical physics; Space (punctuation); Field (mathematics); Killing vector field; Curved space; Classical mechanics; Vector field; Theoretical physics; Gravitation; Derivative (finance); Electromagnetic field

2026-05-14https://doi.org/10.1142/s0217732326501610Modern Physics Letters A 20261Impact of Scarpa's fascia preservation in abdominoplasty: A systematic review and meta-analysisC.A.B. Magalhães; G.F. Machado; K.M. Albuquerque; A. Iqbal; E.F.R. Duraes

Fascia; Fasciotomy; MEDLINE; Scars; Medicine; Surgery

2026-05-15https://doi.org/10.1016/j.bjps.2026.05.029Journal of Plastic Reconstructive & Aesthetic Surgery 20261O consumo de Moda Digital nos Jogos DigitaisO presente trabalho tem como objetivo analisar a inserção das práticas de moda no mercado de jogos digitais, particularmente analisar como a tecnologia de computadores, a dissociação do jogo como uma atividade exclusivamente infanto-juvenil e o crescente interesse das marcas de moda tradicionais no público gamer usando como estudo de caso os jogos League of Legends e Genshin Impact.Fillipe de Souza Montes

League; Digital media; Game studies; The Internet; Digital native; Advertising; Computer science; Business; Internet privacy

2026-05-15https://doi.org/10.5281/zenodo.20190258Zenodo (CERN European Organization for Nuclear Research) 20261O consumo de Moda Digital nos Jogos DigitaisO presente trabalho tem como objetivo analisar a inserção das práticas de moda no mercado de jogos digitais, particularmente analisar como a tecnologia de computadores, a dissociação do jogo como uma atividade exclusivamente infanto-juvenil e o crescente interesse das marcas de moda tradicionais no público gamer usando como estudo de caso os jogos League of Legends e Genshin Impact.Fillipe de Souza Montes

League; Digital media; Game studies; The Internet; Digital native; Advertising; Computer science; Business; Internet privacy

2026-05-15https://doi.org/10.5281/zenodo.20190257Zenodo (CERN European Organization for Nuclear Research) 20261On the type series of Lacerta teguixin Linnaeus, 1758 (Squamata: Teiidae)Tupinambis teguixin (Linnaeus, 1758), one of the largest South American lizards, has a complex nomenclatural history. It was originally named Lacerta teguixin, and a specimen housed in the Uppsala Universitet (UPSZTY 13) was designated the lectotype. Sometime after the 1990’s, the lectotype desiccated, and in 2012, a specimen housed in the Swedish Museum of Natural History (NRM 121) was designated as a “neolectotype”. However, the term “neolectotype” has no standing under the International Code of Zoological Nomenclature, and such a designation is invalid. The type series of Lacerta teguixin most likely included three specimens: one (possibly lost) illustrated in Albertus Seba’s “Locupletissimi Rerum Naturalium Thesauri”, UPSZTY 13 (lectotype), and NRM 123 (paralectotype). Specimens NRM 121 and 122 cannot be confirmed as syntypes, and their status remains uncertain. Additionally, Seba’s specimen might belong to Tupinambis cryptus, making the T. teguixin type series potentially composed of two species. Our review highlights the importance of thorough historical and nomenclatural research before changing type designations to ensure stability and compliance with the Code.Henrique Ernesto Rodrigues Costa; Wolfgang Denzer

Type (biology); Series (stratigraphy); Natural history; Type species; Single specimen; Type specimen; Biology; Zoology; Genealogy

2026-05-14https://doi.org/10.11646/zootaxa.5810.2.6Zootaxa 20261Figurinos Femininos nos Jogos Digitais: Um Olhar Sobre Mortal KombatEste trabalho tem como objetivo analisar as relações entre as tecnologias de produção de jogos digitais e a representação de personagens femininas nos jogos e seus figurinos. Toma como estudo de caso a franquia Mortal Kombat, em que as personagens foram amplamente sexualizadas durante várias edições do jogo, relacionando tal fenômeno aos seus jogadores e ao contexto geral em que esse público se insere.Débora Pinguello Morgado; Fillipe de Souza Montes

Context (archaeology); Order (exchange); Identity (music); Value (mathematics); Art; Humanities

2026-05-14https://doi.org/10.5281/zenodo.20185579Zenodo (CERN European Organization for Nuclear Research) 20261Positive body image is a pathway between nature contact and life satisfaction across 58 nationsTime spent in nature benefits human mental and physical well-being. However, much of the variance in outcomes of nature contact remains unexplained, suggesting that new mechanistic pathways need to be considered. Here, we tested a novel conceptual model linking nature contact with life satisfaction via pathways involving positive experiences of living in and experiencing the world through the physical self. Using data from the Body Image in Nature Survey (BINS; N = 50,363), representing respondents from 58 nations and speaking 36 different languages, we find that nature contact is associated with greater self-compassion and greater perceived restoration in nature, which in turn are associated with more positive body image. In addition, more positive body image is associated with greater life satisfaction. These associations were robust to sensitivity tests, generalised to all gender identities and age groups, and held individually in almost all national groups and languages. Although replications are needed, we propose that the materialities of natural environments help to link bodily experiences to the production and experience of well-being, a process that is largely stable across national groups.Viren Swami; Martin Voracek; Stefan Stieger; Toivo Aavik; Hamed Abdollahpour Ranjbar; Sulaiman Olanrewaju Adebayo; Reza Afhami; Oli Ahmed; Annie Aimé; Marwan Akel; Hussam Al Halbusi; George Alexias; Khawla F. Ali; Nursel AlpDal; Anas B. Alsalhani; Sara ÁlvarezSolas; Ana Carolina Soares Amaral; Sonny Andrianto; Trefor Aspden; Marios Argyrides; John Jamir Benzon R. Aruta; Stephen Atkin; Olusola Ayandele; Migle Baceviciene; Radvan Bahbouh; Andrea Ballesio; David Barron; Ashleigh Bellard; Sóley S. Bender; Kerime Derya Beydağ; Gorana Birovljević; MarieÈve Blackburn; Teresita BorjaAlvarez; Joanna Borowiec; Miroslava Bozogáňová; Solfrid BratlandSanda; Matthew H.E.M. Browning; Anna BrytekMatera; Marina Burakova; Yeliz ÇakırKoçak; Pablo Camacho; Vittorio Emanuele Camilleri; Valentina Cazzato; Silvia Cerea; Apitchaya Chaiwutikornwanich; Trawin Chaleeraktrakoon; Tim Chambers; Qingwei Chen; Xin Chen; ChinLung Chien; Phatthanakit Chobthamkit; Bovornpot Choompunuch; Emilio J. Compte; Jennifer Corrigan; Getrude Cosmas; Richard G. Cowden; Kamila CzepczorBernat; Marcin Czub; Wanderson Roberto da Silva; Mahboubeh Dadfar; Simon E. Dalley; Lionel Dany; Jesus Alfonso D. Datu; Pedro Henrique Berbert de Carvalho; Gabriel Lins de Holanda Coelho; Avila Odia S. De Jesus; Sonia Harzallah Debbabi; Sandesh Dhakal; Francesca Di Bernardo; Donka D. Dimitrova; Jacinthe Dion; Barnaby Dixson; Stacey M. Donofrio; Marius Drysch; Hongfei Du; Angel M. Dzhambov; Claire ElJor; Violeta Enea; Mehmet Eskin; Farinaz Farbod; Lorleen Farrugia; Leonie Fian; Maryanne L. Fisher; Michał Folwarczny; David A. Frederick; Matthew FullerTyszkiewicz; Adrian Furnham; Antonio Aliás Garcia; Shulamit Geller; Marta Ghisi; Alireza Ghorbani; María Ángeles Gómez Martínez; Sarah Gradidge; Sylvie Graf; Caterina Grano; Gyöngyvér Gyene; Souheil Hallit; Motasem Hamdan; Jonathan E. Handelzalts; Paul H. P. Hanel

Life satisfaction; Well-being; Image (mathematics); Quality of life (healthcare); Life style; Psychology; Social psychology; Developmental psychology

2026-05-15https://doi.org/10.1016/j.envint.2026.110277Environment International 20261Figurinos Femininos nos Jogos Digitais: Um Olhar Sobre Mortal KombatEste trabalho tem como objetivo analisar as relações entre as tecnologias de produção de jogos digitais e a representação de personagens femininas nos jogos e seus figurinos. Toma como estudo de caso a franquia Mortal Kombat, em que as personagens foram amplamente sexualizadas durante várias edições do jogo, relacionando tal fenômeno aos seus jogadores e ao contexto geral em que esse público se insere.Débora Pinguello Morgado; Fillipe de Souza Montes

Context (archaeology); Order (exchange); Identity (music); Value (mathematics); Art; Humanities

2026-05-14https://doi.org/10.5281/zenodo.20185580Zenodo (CERN European Organization for Nuclear Research) 20261Potencial terapêutico do transplante de microbiota fecal na artrite reumatoide: uma revisão integrativa de literaturaRheumatoid arthritis (RA) is a inflammatory chronic autoimmune disease that affects the joints. Recent studies highlight that intestinal dysbiosis plays a significant role in the development and progression of RA by influencing the host’s immune system regulation. This study aims to determine the therapeutic potential of fecal microbiota transplantation (FMT) in RA patients. It is an integrative literature review, conducted using PubMed, Virtual Health Library (VHL) and ScienceDirect, with the descriptors "Fecal Microbiota Transplantation" and "Arthritis Rheumatoid". A total of 80 articles from the past 5 years were identified, and after applying the inclusion and exclusion criteria, 13 were selected for the study. Dysbiosis associated with rheumatoid arthritis typically begins in the preclinical phase of the disease and is characterized by reduced microbial diversity. Examples of microbial populations that may be altered in the disease include an increase in Lactobacillus salivarius and Prevotella copri and a decrease in Haemophilus spp. These changes result in the activation of immunological mechanisms, such as molecular mimicry and damage to intestinal barrier function, leading to systemic inflammation and polyarthritis. In this context, fecal microbiota transplantation (FMT) has recently gained prominence as a procedure to treat the autoimmunity involved in the disease. In murine studies, the inhibition of inflammatory cytokines and the induction of anti-inflammatory cytokines were observed as a result of microbiota transplantation from healthy mice to mice with collagen-induced arthritis. Furthermore, in a case report, the procedure demonstrated improvement in disease activity scores. Nonetheless, clinical studies are still necessary to explore fecal microbiota transplantation as a treatment for rheumatoid arthritis.Lorrany Gonçalves Aguiar; Vanessa do Nascimento Ladeira; Maria Edwarda Pagnussat; Victória de Azevedo Bastos; Hérika Palacio Kischel; Ítala Cristina de Matos Marzano

Dysbiosis; Rheumatoid arthritis; Inflammatory bowel disease; Transplantation; Immune system; Autoimmune disease; Microbiome; Disease; Immunology; Medicine; Autoimmunity; Arthritis; Inflammation; Gut flora; Molecular mimicry; Fecal bacteriotherapy

2026-03-31https://doi.org/10.11606/issn.1679-9836.v105i2e-232881Revista de Medicina 20261Grandes editoras científicas x acesso aberto a relação de dominação está mudando?The article discusses the relationship between major scientific publishers and the open access movement, addressing the importance of scientific publications for research evaluation, particularly in the context of CNPq Productivity Grants. It analyzes the scientific output of PQ grantees in the field of Tourism, identifying the journals in which these researchers publish and whether the characteristics of these journals influence their publication choices. The article employs Bourdieu's concept of the Economic Field to understand the dynamics of major scientific publishers, which dominate the publication market, and how this affects the scientific field. It also incorporates recent literature on the topic and links it to the actions of key funding agencies. The research reveals that most articles published by PQ grantees are in open access journals that do not charge publication fees (APC) and allow authors to retain copyright, aligning with open science policies. The study is exploratory, utilizing data provided by CNPq and information from the Lattes Platform. The study suggests the need to rethink policies for evaluating and funding scientific publications, prioritizing journals that promote open access and the democratization of knowledge.Bárbara Quaresma Rocha; Rafael Rocha Ribeiro; Beatriz de Castro Santos

Work (physics); Context (archaeology); Perspective (graphical); Government (linguistics); Agency (philosophy); Political science; Sociology

2026-03-04https://doi.org/10.18226/21789061.v18ip026006Revista Rosa dos Ventos - Turismo e Hospitalidade 20261Material suplementar do artigo "Evolução e Impacto do Programa Meninas Digitais: uma Análise Longitudinal de Indicadores Nacionais" do WIT 2026Os materiais suplementares disponibilizados incluem: (i) base de dados anonimizada utilizada nas análises deste estudo, com remoção de informações de identificação dos projetos e cidades; (ii) formulário de acompanhamento anual dos projetos utilizado na coleta de dados de 2025; e (iii) scripts em Python desenvolvidos para tratamento, organização, análise e geração das visualizações apresentadas no artigo.ANNA BEATRIZ MARQUES; Renata Viegas de Figueiredo; Alessandreia; Mirella M. Moro; Luciana Salgado; Aletéia Patricia Favacho de Araújo

Scripting language; Qualitative research; Procrastination; Context (archaeology); Psychology; Sociology

2026-05-15https://doi.org/10.5281/zenodo.20210719Zenodo (CERN European Organization for Nuclear Research) 20261Material suplementar do artigo "Evolução e Impacto do Programa Meninas Digitais: uma Análise Longitudinal de Indicadores Nacionais" do WIT 2026Os materiais suplementares disponibilizados incluem: (i) base de dados anonimizada utilizada nas análises deste estudo, com remoção de informações de identificação dos projetos e cidades; (ii) formulário de acompanhamento anual dos projetos utilizado na coleta de dados de 2025; e (iii) scripts em Python desenvolvidos para tratamento, organização, análise e geração das visualizações apresentadas no artigo.ANNA BEATRIZ MARQUES; Renata Viegas de Figueiredo; Alessandreia; Mirella M. Moro; Luciana Salgado; Aletéia Patricia Favacho de Araújo

Scripting language; Qualitative research; Procrastination; Context (archaeology); Psychology; Sociology

2026-05-15https://doi.org/10.5281/zenodo.20211096Zenodo (CERN European Organization for Nuclear Research) 20261Neural network surrogates for action potentialsIn this study, we investigate neural network surrogate models for excitable dynamics using the FitzHugh-Nagumo system as a canonical reduced model of cardiac and neuronal action potentials. We compare three classes of architectures-data-driven feedforward networks, physics-informed neural networks (PINNs), and recurrent neural networks (RNNs)-and assess their ability to reproduce the temporal evolution of action potentials. Our evaluation emphasizes stability, long-horizon error accumulation, and fidelity to both the qualitative and quantitative features of the underlying dynamical system. We find that purely data-driven feedforward surrogates can provide accurate and stable approximations in data-rich regimes, offering fast inference and direct access to the solution at arbitrary time points. In contrast, recurrent architectures exhibit substantial error growth over long time horizons, highlighting persistent challenges in learning stable excitable dynamics. PINNs are most beneficial in data-scarce settings, where physics-based regularization improves identifiability and reduces extrapolation error. We further show that parameter regimes near bifurcations are particularly difficult to learn; incorporating physics-informed loss terms can partially alleviate these failures, though not eliminate them. For simple configurations, the proposed surrogates achieve speedups of up to 1.7× over conventional numerical solvers while remaining fully differentiable. However, for more complex and highly parameterized problems, classical differential-equation solvers remain more robust and accurate than the neural surrogate approaches considered here.Yan Barbosa Werneck; Bernardo M. Rocha; Rafael Sachetto Oliveira; Rodrigo W. dos Santos

Artificial neural network; Identifiability; Feed forward; Recurrent neural network; Extrapolation; Parameterized complexity; Regularization (linguistics); Inference; Feedforward neural network; Computer science; Artificial intelligence; Dynamical systems theory; Action (physics); Simple (philosophy); Fidelity; Algorithm; Machine learning; Deep learning

2026-05-01https://doi.org/10.1063/5.0322725Chaos An Interdisciplinary Journal of Nonlinear Science 20261Material suplementar do artigo "Evolução e Impacto do Programa Meninas Digitais: uma Análise Longitudinal de Indicadores Nacionais" do WIT 2026Os materiais suplementares disponibilizados incluem: (i) base de dados anonimizada utilizada nas análises deste estudo, com remoção de informações de identificação dos projetos e cidades; (ii) formulário de acompanhamento anual dos projetos utilizado na coleta de dados de 2025; e (iii) scripts em Python desenvolvidos para tratamento, organização, análise e geração das visualizações apresentadas no artigo.ANNA BEATRIZ MARQUES; Renata Viegas de Figueiredo; Alessandreia; Mirella M. Moro; Luciana Salgado; Aletéia Patricia Favacho de Araújo

Scripting language; Qualitative research; Procrastination; Context (archaeology); Psychology; Sociology

2026-05-15https://doi.org/10.5281/zenodo.20211095Zenodo (CERN European Organization for Nuclear Research) 20261Combination of Measurements of <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"> <mml:mi>C</mml:mi> <mml:mi>P</mml:mi> </mml:math> Properties of Higgs Boson Interactions with Vector Bosons Using Proton-Proton Collisions at <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"> <mml:mrow> <mml:msqrt> <mml:mrow> <mml:mi>s</mml:mi> </mml:mrow> </mml:msqrt> <mml:mo>=</mml:mo> <mml:mn>13</mml:mn> <mml:mtext> </mml:mtext> <mml:mtext> </mml:mtext> <mml:mi>TeV</mml:mi> </mml:mrow> </mml:math> with the ATLAS DetectorA combination of measurements of the CP properties of Higgs boson interactions with electroweak gauge bosons is presented, using 140 fb^{-1} of proton-proton collisions at sqrt[s]=13 TeV recorded by the ATLAS detector. Results from vector boson fusion H→ττ/WW^{*}/γγ, inclusive H→ZZ^{*}, and WH,H→bb[over ¯] channels are combined. No evidence of CP violation is observed, and constrains on the CP-violating operators in the Standard Model effective field theory framework (SMEFT) are set in the Warsaw basis. The results from the combination improve by over 40% on previous individual limits on c_{HW[over ˜]} and, for the first time, simultaneous constraints on three coefficients c_{HW[over ˜]}, c_{HB[over ˜]}, and c_{HW[over ˜]B} are set. These limits are the most stringent constraints to date on the relevant Wilson coefficients in the SMEFT framework with minimum model dependence.G. Aad; E. Aakvaag; B. Abbott; S. Abdelhameed; K. Abeling; N. J. Abicht; S. H. Abidi; M. Aboelela; A. Aboulhorma; H. Abramowicz; B. S. Acharya; A. Ackermann; C. Adam Bourdarios; L. Adamczyk; S. V. Addepalli; M. J. Addison; J. Adelman; A. Adiguzel; T. Adye; A. A. Affolder; Y. Afik; M. N. Agaras; A. Aggarwal; C. Agheorghiesei; A. Ahmad; F. Ahmadov; S. Ahuja; S. Ahuja; X. Ai; G. Aielli; A. Aikot; M. Ait Tamlihat; T. P. A. Åkesson; D. Akiyama; N. N. Akolkar; S. Aktas; G. L. Alberghi; J. Albert; U. Alberti; P. Albicocco; S. Alderweireldt; Z. L. Alegria; M. Aleksa; I. N. Aleksandrov; C. Alexa; T. Alexopoulos; F. Alfonsi; M. Algren; M. Alhroob; B. Ali; H. M. J. Ali; S. Ali; S. W. Alibocus; M. Aliev; G. Alimonti; C. Allaire; B. M. M. Allbrooke; D. R. Allen; J. S. Allen; J. F. Allen; C. S. Alley; E. R. Almazan; A. Aloisio; F. Alonso; C. Alpigiani; A. Alvarez Fernandez; M. Alves Cardoso; M. G. Alviggi; M. Aly; Y. Amaral Coutinho; C. Amelung; M. Amerl; T. Amezza; B. Amini; K. Amirie; A. Amirkhanov; D. Amperiadou; S. An; C. Anastopoulos; T. Andeen; J. K. Anders; A. C. Anderson; A. Andreazza; S. Angelidakis; A. Angerami; A. V. Anisenkov; A. Annovi; C. Antel; E. Antipov; M. Antonelli; F. Anulli; M. Aoki; T. Aoki; M. A. Aparo; L. Aperio Bella; M. Apicella; C. Appelt; A. Apyan; M. Arampatzi; S. J. Arbiol Val

Boson; Higgs boson; Vector boson; Elementary particle; Scalar boson; Standard Model (mathematical formulation); Physics; Particle physics; Nuclear physics; Interacting boson model; Particle decay

2026-05-15https://doi.org/10.1103/54vv-lgc7Physical Review Letters 20261Material suplementar do artigo "Evolução e Impacto do Programa Meninas Digitais: uma Análise Longitudinal de Indicadores Nacionais" do WIT 2026Os materiais suplementares disponibilizados incluem: (i) base de dados anonimizada utilizada nas análises deste estudo, com remoção de informações de identificação dos projetos e cidades; (ii) formulário de acompanhamento anual dos projetos utilizado na coleta de dados de 2025; e (iii) scripts em Python desenvolvidos para tratamento, organização, análise e geração das visualizações apresentadas no artigo.ANNA BEATRIZ MARQUES; Renata Viegas de Figueiredo; Alessandreia; Mirella M. Moro; Luciana Salgado; Aletéia Patricia Favacho de Araújo

Scripting language; Qualitative research; Procrastination; Context (archaeology); Psychology; Sociology

2026-05-15https://doi.org/10.5281/zenodo.20210718Zenodo (CERN European Organization for Nuclear Research) 20261Relações entre configuração urbana e vitalidade das praças de Juiz de Fora (MG)Objective – to investigate the relationship between urban street network configuration and the vitality of 84 public squares in the municipality of Juiz de Fora (MG), considering not only configurational aspects but also the physical characteristics of these spaces that may contribute to or hinder their appropriation and use.Methodology – the study adopts a quantitative approach based on the analysis of syntactic measures of the urban network (INT.R3, NAIN, NACH, and INCH) and the measurement of user density in each square, seeking to identify statistical correlations between spatial configuration and patterns of use of public spaces.Originality/Relevance – by empirically investigating the relationship between spatial configuration and the urban vitality of public squares in the Brazilian context, this study expands the body of evidence linking Space Syntax to public spaces. It stands out for analyzing the entirety of a city’s public squares, overcoming approaches based on reduced samples, and for employing statistical instruments that enable an integrated assessment of urban morphology and patterns of use of public open spaces.Results – the results indicate that public squares in Juiz de Fora present heterogeneous distributions and vitality patterns across Planning Regions, with a greater concentration of both squares and vitality levels in the city’s central area. Statistical analyses revealed positive and significant correlations between user density and the syntactic measures, although with weak to moderate magnitude, indicating that urban configuration influences vitality but does not act as a determining factor. Contrasting cases stand out, such as Praça Armando Toschi, which shows high vitality in a context of low integration, and Praça Mundo Novo, which, despite high spatial integration, records low levels of use, highlighting the limits of spatial configuration as an isolated factor.Theoretical/Methodological Contributions – the study reinforces the contribution of Space Syntax Theory to the understanding of urban vitality by evidencing its scope and limitations when applied empirically and tested statistically. Methodologically, it highlights the analysis of the entire set of public squares in a city and the articulation between syntactic measures and observational data on use, contributing to integrated approaches in the investigation of public open spaces.Social and Environmental Contributions – the findings provide support for urban planning by indicating that the qualification and use of public squares depend on the articulation between spatial configuration, physical attributes, and surrounding land uses. In this sense, the study may guide public policies aimed at improving, redistributing, and creating public squares, promoting greater social inclusion, access to leisure facilities, and the valorization of urban public spaces.Klaus Chaves Alberto; Lídia Maia Moreira; Sabrina Andrade Barbosa

Vitality; Appropriation; Context (archaeology); Public space; Space syntax; Statistical analysis; Urban planning; Sociology; Geography; Public use

2026-05-15https://doi.org/10.17271/23188472149120266363Revista Nacional de Gerenciamento de Cidades 20261Prevalência do uso de medicamentos potencialmente inapropriados por idosos hipertensos de Diamantina (MG) e fatores associadosResumo Introdução: Apesar dos benefícios da farmacoterapia, os idosos carecem de maior atenção farmacêutica, pois a prática da polifarmácia aumenta as chances de resultados negativos em saúde, principalmente devido ao maior risco de exposição aos Medicamentos Potencialmente Inapropriados (MPIs). Objetivo: identificar a prevalência do uso de MPIs por idosos hipertensos assistidos pela Estratégia Saúde da Família de Diamantina (MG) e analisar os fatores associados. Método: Estudo transversal retrospectivo envolvendo 325 idosos acometidos por hipertensão arterial, cujos dados foram coletados por meio de entrevista domiciliar, entre novembro de 2018 e dezembro de 2019. O teste do χ2 foi aplicado às covariáveis categóricas e o teste t às covariáveis contínuas. A regressão logística binária múltipla testou se as covariáveis afetavam condicionalmente a probabilidade do uso de MPIs na presença de controles simultâneos, ao passo que o modelo de classe latente com covariáveis ativas identificou perfis multivariados segundo uso de MPIs. Resultados: A prevalência do uso de MPIs foi de 78,5% e este foi significativamente maior entre pacientes polifármacos (47,4%) e pacientes do sexo feminino (62,5%). Os MPIs mais utilizados foram Hidroclorotiazida, Omeprazol, Furosemida e Glibenclamida. Conclusão: A população assistida faz elevado uso de MPIs, reforçando a necessidade de monitorização da farmacoterapia aplicada à população idosa.Janete Higino Alves; Carlos Alberto Dias; Gilvan Ramalho Guedes; Lauro César da Silva Maduro

Test (biology); Exploratory research; Data collection; Entitlement (fair division); Qualitative research; Medicine; Gerontology

2026-01-01https://doi.org/10.1590/1414-462x202634010011Cadernos Saúde Coletiva 20261Direitos Humanos E Dever Estatal AmbientalO artigo analisa o uso de imagens como prova em processos judiciais ambientais e sua contribuição para a proteção ambiental no sul do Amazonas, com foco nos municípios de Apuí e Lábrea. Articula o Direito das Provas, o Direito Ambiental e os Direitos Humanos, fundamentando-se no reconhecimento constitucional do meio ambiente como um direito fundamental e na responsabilidade do Estado de promovê-lo em contextos de vulnerabilidade socioambiental e presença institucional limitada. Nesse contexto, a proteção ambiental depende da capacidade de produzir, admitir e avaliar provas em situações que envolvem danos ambientais complexos. Como foco empírico, o estudo examina o caso Ricardo Stoppe, investigado no âmbito da Operação Greenwashing, em que imagens teriam sido utilizadas para conferir aparência de legalidade a práticas ilícitas, revelando a natureza ambivalente da prova baseada em imagens. A pesquisa adota uma abordagem qualitativa, combinando análise documental, revisão bibliográfica interdisciplinar e análise do caso. Em territórios com fiscalização in loco limitada, as imagens estruturam a reconstrução dos fatos e viabilizam a atuação judicial. Contudo, lacunas normativas, deficiências na formação técnica e fragilidades na coordenação interinstitucional afetam a admissibilidade e a avaliação racional de tais provas. Conclui-se, provisoriamente, que é necessário um quadro institucional mais robusto para fortalecer o Estado de Direito e a governança ambiental.Ernesto Ribeiro de Souza Lima Benetello; Manoela Carneiro Roland

Legal culture; Context (archaeology); Human rights; Jurisprudence; Legal norm; Constitution; Michel foucault; Vulnerability (computing); Political science; Humanities; Sociology; Philosophy

2026-05-01https://doaj.org/article/716c0db7eb4146ad8759d6ff2372a4ccDOAJ (DOAJ: Directory of Open Access Journals) 20261Colonialidade Verde e Transição Energética JustaA presente pesquisa tem por objetivo analisar criticamente as contradições inerentes ao modelo hegemônico de transição energética no contexto do capitalismo globalizado, investigando de que modo as atuais arquiteturas de governança climática e as estratégias de atuação de corporações transnacionais impactam a efetivação dos direitos humanos. Parte-se da compreensão de que a transição energética constitui uma inovação tecnológica e financeira de grande escala, ancorada em novos instrumentos de mercado, métricas ambientais e arranjos regulatórios voltados à descarbonização. Contudo, sustenta-se que, quando tais inovações não são acompanhadas por correspondentes inovações democráticas e jurídicas, capazes de redistribuir poder e assegurar participação substantiva das comunidades afetadas, a transição tende a reatualizar lógicas coloniais de apropriação territorial, reproduzindo desigualdades históricas e promovendo violações sistemáticas contra povos indígenas, comunidades quilombolas e outros povos tradicionais. Metodologicamente, o estudo adota uma abordagem qualitativa de orientação teórico-crítica, fundamentada em revisão bibliográfica interdisciplinar e análise documental de instrumentos normativos internacionais, articuladas ao exame de um estudo de caso situado no território brasileiro. O arcabouço teórico se apoia na teoria crítica dos direitos humanos desenvolvida por Joaquín Herrera Flores, em diálogo com o pensamento decolonial e com o campo de Empresas e Direitos Humanos, com destaque para os Princípios Orientadores das Nações Unidas. Os resultados evidenciam que a observância meramente formal de standards ambientais e taxonomias de sustentabilidade revela-se insuficiente para prevenir violações socioambientais, sobretudo diante da ausência de mecanismos jurídicos vinculantes de responsabilização extraterritorial de atores corporativos. Conclui-se que uma transição energética efetivamente justa exige a centralidade dos direitos humanos, compreendidos como processos históricos e conflituosos de luta pela dignidade, bem como o reconhecimento político das resistências populares como sujeitos constituintes e o fortalecimento de instrumentos jurídicos capazes de enfrentar as violações produzidas pela atuação corporativa transnacional.Ana Carolina Souza Santos; Joana de Souza Machado; Manoela Carneiro Roland

Context (archaeology); Human rights; Latin Americans; Power (physics); Humanities; Political science; Philosophy

2026-05-01https://doaj.org/article/680ab56e7a404780a1a85ead691803c9DOAJ (DOAJ: Directory of Open Access Journals) 20261Scenario Datasets to support the paper "Multi-Region Modeling and Integration In Expansion Planning Using OSeMOSYS"The dataset contains input data files of the Brazilian case study described in the paper. Scenario files are divided into separate directories. The dataset contains the input data and respective files needed to run OSeMOSYS using the conventional and the modified optimization models. This dataset DOES NOT contain simulation results of the study "Multi-Region Modeling and Integration In Expansion Planning Using OSeMOSYS", due to substantial sizes of output files from scenario simulation. This study evaluates expansion planning models under different temporal, spatial and technological resolutions. An additional toy problem modeling an energy system of a hypothetical country 'Brazago', has also been added to the repository. It presents results for the simulation of the energy system using two OSeMOSYS formulations -- the original formulation, where inter-region trades are modeled as an net exchange of fuel; and the proposed formulation, which employs the methodology described in the article "Multi-Region Modeling and Integration In Expansion Planning Using OSeMOSYS".Pedro H. Peters Barbosa; Bruna Caroline Ferreira; Paulo Vitor B. Ramos; Leonardo Bitencourt; Taco Niet; Bruno de Borba; Bruno Dias

Data integration; Data modeling; Spatial analysis; Key (lock); Data file; Computer science; Data mining

2026-05-15https://doi.org/10.5281/zenodo.20214507Zenodo (CERN European Organization for Nuclear Research) 20261Do Active Teaching Methodologies Improve the Performance of Dental Students? A Systematic Review and Meta‐AnalysisINTRODUCTION: Despite the growing number of studies comparing active and traditional methodologies, there is a lack of updated systematic syntheses evaluating active methodologies focusing on academic performance in dentistry. Thus, the aim was to systematically evaluate the evidence about the impact of active teaching methodologies compared to the traditional method on the academic performance of undergraduate dental students. MATERIALS AND METHODS: The review protocol was registered on PROSPERO (CRD42023472330). Eligibility criteria included randomised clinical trials (RCT) involving undergraduate dental students, comparing at least one active teaching methodology to a traditional, using quantitative methods to evaluate the results. Outcomes were considered successful when they showed statistically significant improvement in knowledge acquisition, skills performance or competency measures compared to traditional teaching. The RevMan software was used for meta-analysis (p < 0.05). Two independent reviewers conducted searches in PubMed/MEDLINE, Embase, Web of Science and Scopus, as well as in grey literature and manual reference lists, published up to December 2024. Risk of bias was assessed using the RoB 2 tool. The certainty of evidence was evaluated using the GRADE (Grading of Recommendations Assessment, Development and Evaluation) approach. RESULTS: A total of 1277 studies were identified and 20 met the eligibility criteria. Only 18 were included in the meta-analysis. Active methodologies were associated with higher academic performance after the intervention (p < 0.001) and better retention after 1 month (p < 0.001), compared with traditional teaching. Baseline analysis showed equivalence between groups before the intervention (p = 0.75). The certainty of evidence was rated as low for all outcomes. CONCLUSION: The use of active methodologies in dental education is related to better academic performance of dental students in comparison to traditional teaching.Rafaella S. N. C. Carneiro; Tatiana A. M. do Nascimento; Francielle S. Verner; Cleidiel A. A. Lemos; Rafael B. Junqueira

Protocol (science); MEDLINE; Intervention (counseling); Dental education; Meta-analysis; Grey literature; Systematic review; Randomized controlled trial; Active learning (machine learning); Medical education; Medicine; Psychology; Medical physics; Program evaluation; Educational measurement; Baseline (sea); Evidence-based dentistry; Computer science; Evaluation methods

2026-05-16https://doi.org/10.1111/eje.70190European Journal Of Dental Education 20261ContributorsDaniel Camilo Aguirre Acevedo; Marco Antonio Altamirano-Cruz; Matheus Azi; Mahmoud Badran; J Barla; William Belangero; Claudia Arroyo Berezowsky; Fernando Bidolegui; Guido Carabelli; Juan Manuel Concha; Jorge Hernando Donado-Gomez; Maria Fernanda Echeverry; Robinson Esteves Pires; Asdrubal Falavigna; Vincenzo Fin Falavigna; Iván Florez; Anderson Freitas; German Garabano; María Fernanda García Rueda; Joshua Layne Gary; Peter Giannoudis; Vincenzo Giordano; Amparo Gomez; Phillip Thomas Grisdela; Cameron William Harris; Olesja Hazenbiller; Oscar Javier Morales-Guerrero; Alexander Joeris; Lys Kang; Ahmed Kholeif; Kodi Edson Kojima; Pedro Labronici; Maria Eduarda Lima Viapiana; Janneke I. Loomans; Madeline C. MacKechnie; Cyril Mauffrey; Adriano F. Mendes Jr.; Theodore Miclau III; Andres F Moreno-Diaz; Fintan Moriarty; William Obremskey; José L. Osma-Rueda; Sebastián Pereira; Rodrigo Pesantez; Charalampos Pitsilos; Noémie Reinert; R. Geoff Richards; Paul Rodham; An Sermon; Martin J. Stoddart; Juan C. Uribe-Caputi; Carlos Oliver Valderrama-Molina; Alejandro Vallejo Diaz; Anne-Catherine Vanhove; Jorge Enrique Velarde Bouche; Reece Vesperman; André Wajnsztejn; Gustavo Waldolato; Danilo Taype Zamboni; John Jairo Zuleta-Tobón

2026-01-01https://doi.org/10.1016/b978-0-443-34264-6.01002-9Elsevier eBooks

20261Scenario Datasets to support the paper "Multi-Region Modeling and Integration In Expansion Planning Using OSeMOSYS"The dataset contains input data files of the Brazilian case study described in the paper. Scenario files are divided into separate directories. The dataset contains the input data and respective files needed to run OSeMOSYS using the conventional and the modified optimization models. This dataset DOES NOT contain simulation results of the study "Multi-Region Modeling and Integration In Expansion Planning Using OSeMOSYS", due to substantial sizes of output files from scenario simulation. This study evaluates expansion planning models under different temporal, spatial and technological resolutions. An additional toy problem modeling an energy system of a hypothetical country 'Brazago', has also been added to the repository. It presents results for the simulation of the energy system using two OSeMOSYS formulations -- the original formulation, where inter-region trades are modeled as an net exchange of fuel; and the proposed formulation, which employs the methodology described in the article "Multi-Region Modeling and Integration In Expansion Planning Using OSeMOSYS".Pedro H. Peters Barbosa; Bruna Caroline Ferreira; Paulo Vitor B. Ramos; Leonardo Bitencourt; Taco Niet; Bruno de Borba; Bruno Dias

Data integration; Data modeling; Spatial analysis; Key (lock); Data file; Computer science; Data mining

2026-05-15https://doi.org/10.5281/zenodo.20214508Zenodo (CERN European Organization for Nuclear Research) 20261Critical reading of an article (WORKSHOP)Vincenzo Giordano; Anderson Freitas; Adriano F. Mendes Jr.; Pedro Labronici

Reading (process); Critical reading; Process (computing); Critical practice; Constant (computer programming); Critical thinking; Computer science; Psychology

2026-01-01https://doi.org/10.1016/b978-0-443-34264-6.00032-0Elsevier eBooks 20261Modelagem de Desempenho da Seleção Nacional de Árbitros de Futebol (SENAF) da Confederação Brasileira de Futebol (CBF)A pesquisa na arbitragem em futebol tem crescido consideravelmente nos últimos anos. Porém, no Brasil, sabemos pouco sobre os árbitros e muito menos sobre o seu treinamento e desenvolvimento. Este estudo apresenta o modelo de avaliação multidimensional da performance da Seleção Nacional de Árbitros de Futebol da Confederação Brasileira de Futebol (SENAF-CBF) para árbitros, árbitros assistentes e árbitros assistentes de vídeo. Os indicadores dos testes físicos habilitadores (sprints, agilidade e resistência), antropometria (massa corporal, estatura e dobras cutâneas), testes físico-motores (flexibilidade, CMJ, YoYo), tomada de decisão baseada em vídeos, experiência profissional, quantidade e qualidade dos treinamentos, competência percebida, estados de humor, autoeficácia e a performance de jogo foram integrados e analisados, gerando um diagnóstico do perfil dos árbitros, que irá orientar o processo de desenvolvimento da performance. Um exemplo de resultado individual é apresentado. Este estudo inédito, multidisciplinar e longitudinal pretende contribuir para a melhoria da arbitragem no futebol brasileiro.Emerson Filipino Coelho; Rodrigo Martins Cintra; Francisco Zacaron Werneck

Order (exchange); Process (computing); Work (physics); Humanities

2026-05-16https://doi.org/10.53660/prw-2916-5209Peer Review 20261Colchicine-induced chromosome duplication via callus-derived adventitious bud regeneration in Stylosanthes guianensis (Aubl.) Sw. (Fabaceae)Eduarda Schmitz Furtado Hauck; Rafael Coelho Vallotti; Ana Clara Alves Martins; Danilo Bernardineli de Oliveira; Thamires Fernanda Gomes; Diego Ismael Rocha; Maurecilne Lemes da Silva; Lyderson Fácio Viccini; Marcelo Ayres Carvalho; Aryane Campos Reis; Saulo Marçal de Sousa

Regeneration (biology); Stylosanthes; Chromosome; Gene duplication; Basal shoot; Biology; Botany; Genetics

2026-05-17https://doi.org/10.1016/j.sajb.2026.05.015South African Journal of Botany 20261Vulnerabilidade social e habilidades linguísticasGustavo Henrique das Chagas Moura; Mercedes Marcilese

2026-01-26https://doi.org/10.5281/zenodo.18380453Zenodo (CERN European Organization for Nuclear Research)

20261Do we really know the prevalence of frailty in patients undergoing hemodialysis?Frailty is a prevalent condition among patients with chronic kidney disease (CKD) and is associated with adverse clinical outcomes.1,2 Its reported prevalence in this population varies substantially across studies, primarily due to differences in disease stage, kidney replacement modality, sociodemographic characteristics, and diagnostic criteria.1,2 A scoping review identified 40 different frailty metrics applied to patients across all stages of CKD, with reported frailty prevalence ranging from approximately 5% to 80%.1 Among these metrics, the Fried frailty phenotype is the most commonly used in the CKD population.1,2 Notably, even among studies using the Fried frailty phenotype, substantial variability in frailty prevalence has been reported, potentially due to differences in cutoff values and in the tools used to assess its components.1 However, the extent to which frailty prevalence varies within a single frailty tool, specifically the Fried frailty phenotype, when different cutoffs and assessment methods are applied has not been well established in patients with CKD undergoing hemodialysis. Therefore, this study aimed to quantify the variation in frailty prevalence assessed by the Fred frailty phenotype when different cutoffs and assessment tools are used in patients undergoing hemodialysis.Ana Clara Cattete Bainha; Bruno Valle Pinheiro; Luciana Angélica da Silva de Jesus; Lêda Marília Fonseca Lucinda; Maycon Moura Reboredo

MEDLINE; Nephrology; Epidemiology; Risk assessment; Medicine; Emergency medicine; Intensive care medicine; Internal medicine

2026-01-14https://doi.org/10.1093/joneph/aajag007Journal of Nephrology 20261Breastfeeding combined with cryotherapy using Buzzy® for pain management during infant vaccination: a clinical trialABSTRACT Objective: to evaluate the effect of breastfeeding combined with cryotherapy using the Buzzy® vibratory device on reducing pain in infants during pentavalent vaccine administration. Method: randomized clinical trial conducted in the vaccination sector of a municipality in Minas Gerais, between May and November 2023. Sixty-two infants, aged between 2 and 12 months, participated, randomly and equally allocated into two groups: control (institutional routine) and experimental (breastfeeding combined with cryotherapy using Buzzy®). During vaccine administration, pain was assessed using the Neonatal Infant Pain Scale and by crying time. Data were subjected to descriptive and inferential analysis. Results: in the control group, all infants obtained a pain score ≥4, with an average of 6.5 points on the scale, characterizing the presence of moderate to intense pain, and 29.1% of infants cried for more than 46 seconds. In the experimental group, 57.6% obtained a score ≥4, with an average of 3.7, and 90.9% cried for less than 30 seconds, showing a significant reduction in pain (p < 0.001). Conclusion: breastfeeding associated with cryotherapy with Buzzy® proved effective in pain management, and may contribute to a less painful childhood vaccination practice. There is a need for training for professionals and active participation from the mother/family.Tayene de Oliveira Souza; Luana Vieira Toledo; Luciene Muniz Braga; Hérica Silva Dutra; Suellen Cristina Dias Emídio; Nathalia de Oliveira Martins; Nicacia Cristina Cunha Costa; Paula Krempser

Cryotherapy; Breastfeeding; Crying; Clinical trial; Randomized controlled trial; Pain scale; Pain management; Medicine; Physical therapy; Vaccination; Pain score; Pediatrics; Randomization

2026-01-01https://doi.org/10.1590/1983-1447.2026.20250228.enRevista gaúcha de enfermagem 20261PREVENTION, SURVEILLANCE, AND EARLY DETECTION OF HEPATOCELLULAR CARCINOMA – A BRAZILIAN MULTIDISCIPLINARY CONSENSUSBackground: Hepatocellular carcinoma (HCC) is a major cause of cancer-related mortality and represents a growing public health challenge. Aims: To develop multidisciplinary evidence-based recommendations for the prevention and early detection of HCC. Methods: This consensus was coordinated by the Brazilian Society of Surgical Oncology, with the participation of 13 additional national societies. A steering committee defined the key clinical questions addressing prevention, surveillance, and early detection strategies. Recommendation statements were informed by a comprehensive, non-systematic review of the literature conducted using PubMed, Scopus, and the Cochrane Library. Results: Eighteen recommendations reached consensus, covering three main domains: (1) Primary prevention, including HBV vaccination, timely antiviral therapy for viral hepatitis, and lifestyle interventions for metabolic dysfunction. (2) Secondary prevention, outlining risk-based surveillance strategies for patients with advanced fibrosis or cirrhosis due to HBV, HCV, or MASLD. (3) Operational standards for surveillance, emphasizing ultrasound as the cornerstone of monitoring, the importance of structured reporting, management of small nodules, and the selective use of cross-sectional imaging. Conclusions: These multidisciplinary recommendations provide practical, adaptable guidance for HCC prevention, surveillance, and early detection. This guidance document aims to reduce the burden of HCC and support better clinical outcomes across diverse healthcare settings.Alexandre Ferreira Oliveira; Rafael Soares Nunes Pinheiro; Renata D’Alpino Peixoto; Munir Murad Júnior; Joaquim Maurício da Motta-Leal-Filho; Marcos Roberto de Menezes; Cristina Melo Rocha; Guilherme Martins; Agnaldo Soares Lima; Marcelo Bruno Rezande; Héber Salvador de Castro Ribeiro; Mário Rino Martins; Paulo Herman; Anelisa K. Coutinho; Ângelo Alves de Mattos; Luiz Augusto Carneiro D′Albuquerque; Orlando Jorge Martins Torres; Luiz Arnaldo Szutan; Arthur Accioly Rosa; Duílio Reis da Rocha Filho; Antônio Nocchi Kalil; Cássio Virgílio Cavalcante de Oliveira; Mauro Monteiro Correia; Paulo Cézar Galvão do Amaral; Francisco Tustumi; Wellington Andraus; Ilka de Fátima Santana Ferreira Boin; Rodrigo Nascimento Pinheiro; Heládio Feitosa Neto; Paulo Henrique de Sousa Fernandes; André L. Godoy; Carlos Eduardo Brandão‐Mello; Alexcia Camila Braun; Maria Ignez Braghiroli; Tércio Genzini; José Huygens Parente Garcia; Daniel Neves Fortes; Alessandro Landskron Diniz; Guilherme Moura Cunha; Flair José Carrilho; Carla Caparroz; Luis César Bredt; Felipe José Fernández Coimbra

Multidisciplinary approach; Hepatocellular carcinoma; Psychological intervention; Multidisciplinary team; Clinical Practice; Cirrhosis; Public health; Medicine; Intensive care medicine; MEDLINE; Health care; Family medicine; Palliative care; Clinical trial; Hepatitis B

2026-05-15https://doi.org/10.1590/0102-672020260000018e1947 20261Repositioning 2‐Mercaptobenzothiazole and Sulfonamides as Antifungals Against Multidrug‐Resistant Candida albican s: In Vitro and In Silico InsightsABSTRACT Fungal infections caused by Candida albicans represent a major global health concern, particularly due to the increasing prevalence of multidrug‐resistant (MDR) strains and the limited antifungal arsenal. Drug repositioning offers a strategic approach for the rapid identification of new therapeutic alternatives. In this study, we evaluated the antifungal activity of 2‐mercaptobenzothiazole (MBT) and selected sulfonamides against an MDR C. albicans strain (ATCC 10231) resistant to fluconazole, itraconazole, voriconazole, and anidulafungin. Following CLSI M27‐A3 guidelines, MBT exhibited the highest activity (MIC = 12.5 µg/mL), while sulfonamides showed MIC values ranging from 50 to 100 µg/mL, all markedly superior to fluconazole (MIC = 1000 µg/mL). The antifungal activity observed under the experimental conditions was consistent with a fungistatic effect. Molecular docking studies revealed favorable binding affinities toward lanosterol 14α‐demethylase (L14αDM; PDB ID: 5V5Z), with binding energies of –6.3 kcal mol −1 for MBT and –6.5 kcal mol −1 for sulfanilamide, supporting a plausible azole‐like mechanism of action. These findings reinforce the repositioning potential of these scaffolds as promising antifungal candidates and provide a foundation for further in vivo evaluation, mechanistic elucidation, and combination therapy strategies against MDR candidiasis.Bruno A. de Oliveira; Ari Sérgio de Oliveira Lemos; Gianluigi Lazzarini; Natasha Silva Mayrink; Elaine Soares Coimbra; Adilson D. da Silva; Rodrigo Luiz Fabri

In silico; Antifungal; Fluconazole; Drug; Binding affinities; In vivo; Docking (animal); In vitro; Chemistry; Pharmacology; Lanosterol; Computational biology; Antifungal drugs; Mechanism of action; Biochemistry; Combination therapy; Drug repositioning; Protein Data Bank (RCSB PDB); Antifungal drug

2026-05-01https://doi.org/10.1002/slct.73405ChemistrySelect 20261A76-14 Cardiopulmonary Alterations in Mice With Elastase-induced Pulmonary EmphysemaAbstract Introduction Airflow limitation in pulmonary emphysema (PE) affects pulmonary mechanics in terms of static and dynamic hyperinflation, which in turn can also influence cardiac performance. Objective To evaluate the structure of hearts and lungs in mice subjected to an experimental model of elastase-induced pulmonary emphysema. Method Male C57BL/6 mice were randomly distributed into two main groups: control (CTRL) and PE. The PE group animals received four intratracheal instillations of porcine pancreatic elastase (PPE) at one-week intervals (0.2 IU in 50 μL of saline). The CTRL group received the same volume of saline solution (50 μL). Four weeks after the last instillation, the animals were euthanized for the collection of lungs and hearts for histopathological analysis. Heart sections were stained with hematoxylin and eosin for analysis of cardiomyocyte diameter. Results Stereological analyses showed that the volume density of alveolar air space (Vv [a]) was higher in the PE group (71.02%; 66.65-76.49) compared to the CTRL group (55.55%; 50.55-62.70). The volume density of alveolar septa (Vv [sa]) was lower in the PE group (24.85%; 20.39-28.98) compared to the control group (34.38%; 28.52-38.95). The mean linear intercept showed increased alveolar wall rupture in the PE group (378.40 ± 48.40 mm) compared to the control group (260.50 ± 71.02 mm). The PE group showed a larger cardiomyocyte diameter in the left ventricle (14.46 ± 0.21 mm) and a smaller diameter in the right ventricle (13.15 ± 0.28 mm) compared to the control group (13.10 ± 0.17 and 14.16 ± 0.33 mm, respectively). Conclusion PE caused a structural imbalance in the heart, inducing left ventricular hypertrophy and right ventricular atrophy. This type of alteration can have serious consequences for cardiac function. The hypertrophy of the left ventricle and the possible atrophy of the right ventricle create a disbalance that can lead to blood pumping problems, increased pressure, and long-term dysfunctions. This abstract is funded by: Fundação Educacional Lucas Machado – FELUMA; National Council for Scientific and Technological Development (CNPq); Research Support Foundation of the State of Minas Gerais (Fundação de Amparo à Pesquisa do Estado de Minas Gerais – FAPEMIG)M Rodrigues-machado; I A Carvalho-Ribeiro; G S Magalhaes; L Capettini; M T S Dias; O L M Moreno; F S Bezerra; P A Machado-Junior; M M L T Bombardelli; C H Castro

Ventricle; H&E stain; Saline; Elastase; Lung; Alveolar Wall; Pancreatic elastase; Medicine; Pathology; Cardiology; Internal medicine; Lung volumes

2026-05-01https://doi.org/10.1093/ajrccm/aamag162.1714American Journal of Respiratory and Critical Care Medicine 20261Therapeutic ultrasound in elbow fractures rehabilitation: randomized clinical trial protocolElbow fractures often require surgical treatment due to their complexity and may lead to joint stiffness and functional impairment. Physical therapy is essential for restoring range of motion (ROM) and function; however, despite its widespread clinical use, the postoperative use of ultrasound for ROM recovery still lacks consistent clinical evidence. To investigate the additive effect of therapeutic ultrasound combined with a rehabilitation protocol on ROM, pain, strength, and elbow function during the postoperative period following elbow fractures. A triple-blind, randomized controlled clinical trial protocol involving 50 patients. The intervention group will receive ultrasound 3 megahertz (MHz), 1 watts per square centimeter (W/cm2), continuous mode for 10 sessions, while the control group will receive sham ultrasound. Both groups will follow a 5 week physiotherapy protocol. Assessments will take place at baseline, after 6 and 10 weeks, and at a 6 month follow-up. The primary outcome is elbow flexion-extension ROM, and secondary outcomes include grip strength, pain, and functionality. Analyses will follow the intention to treat principle using mixed linear models. This study may provide relevant evidence on the role of therapeutic ultrasound in postoperative rehabilitation following elbow fractures.Clinical trial registration The https://ensaiosclinicos.gov.br/ identifier is RBR-4shpqhj.Priscila Monteiro Veras; José da Mota Neto; Liliany Fontes Loures; Priscilla Ganimi Tavella Lacerda; Bruno Lionardo de Paula; Richard Eloin Liebano; Diogo Simões Fonseca; Maycon Moura Reboredo

Randomized controlled trial; Therapeutic ultrasound; Elbow; Protocol (science); Clinical trial; Ultrasound; Medicine; Surgery; MEDLINE; Physical therapy

2026-05-18https://doi.org/10.1080/17581869.2026.2674768Pain Management 20261Validation and measurement invariance of the Intuitive Eating Scale-3 among Brazilian adolescentsIntuitive eating is an evidence-based, non-diet approach to nutrition that heals individuals' relationship with food by listening to internal body cues rather than external rules. The Intuitive Eating Scale is a widely used measure that has been validated across diverse cultural contexts and among individuals of different sociocultural backgrounds. However, its third version (IES-3) is not available for adolescents, an at-risk population for eating disorders and body image disturbances. In the present study, we perform the validation of the IES-3 in a sample of 295 Brazilian adolescents. Confirmatory factor analysis (CFA) and exploratory structural equation modeling (ESEM) supported the original four-factor structure of the measure, after excluding IES-3 Item #6. Bifactor CFA support a global scale score. Full measurement invariance was found between male and female adolescents. Additionally, we found good convergent validity with measures of emotional eating, external eating, restrained eating, body acceptance by others, body appreciation, and body dissatisfaction. Finally, we found good internal consistency for IES-3 total scores and two subscales. Results support the use of the measure in Brazilian adolescents, allowing for future studies on eating disorder prevention and intervention. • IES-3 showed good psychometric properties for Brazilian adolescents. • The original four-factor structure was supported after excluding one IES-3 item. • Full sex invariance was observed across Brazilian male and female adolescents. • IES-3 scores were inversely related to maladaptive eating and body dissatisfaction. • IES-3 scores were positively related to positive body image.Daena Cunha de Fialho; Tracy L. Tylka; Thainá Richelli Oliveira Resende; Wanderson Roberto da Silva; Marle dos Santos Alvarenga; Pedro Henrique Berbert de Carvalho

Measurement invariance; Psychometrics; Test validity; Validation test; Confirmatory factor analysis; Psychology; Developmental psychology; Social psychology

2026-04-01https://doi.org/10.1016/j.eatbeh.2026.102093Eating Behaviors 20261AEROBIC EXERCISE ATTENUATES HEPATIC LIPID PEROXIDATION IN AN EXPERIMENTAL MODEL OF OBESITY-ASSOCIATED NAFLDBACKGROUND: The global rise in obesity has been accompanied by an increasing prevalence of nonalcoholic fatty liver disease (NAFLD), for which effective non-pharmacological therapeutic strategies remain limited. OBJECTIVE: This study investigated the effects of aerobic exercise on hepatic oxidative stress in an experimental model of obesity-associated NAFLD. METHODS: Newly weaned Wistar rats were fed a highly palatable, obesity-inducing diet. After obesity was established, the animals were randomly assigned to either a trained group (n=12) or a sedentary group (n=12). The trained group underwent moderate-intensity treadmill running for eight weeks. Hepatic lipid peroxidation was assessed using the TBARS (thiobarbituric acid reactive substances) assay. RESULTS: Aerobic training significantly reduced hepatic TBARS levels (P<0.0005), in an average of 1.8 nmol MDA/mg protein compared to the sedentary group. These benefits were significant regardless of weight gain maintenance. CONCLUSION: The findings suggest that regular physical exercise attenuates hepatic lipid peroxidation in an experimental model of obesity-associated NAFLD. The results support that physical exercise is an effective non-pharmacological strategy for modulating oxidative stress and preventing disease progression.Maria Luiza Rodrigues Pereira Lima; Carolina Rosa Gioda; Laura Hora Rios LEITE; Cândido Celso Coimbra; B Pinto Coelho de Carvalho Correa; Virgínia Hora Rios Leite; Teresa Cristina Abreu Ferrari

TBARS; Nonalcoholic fatty liver disease; Aerobic exercise; Lipid peroxidation; Oxidative stress; Treadmill; Obesity; Thiobarbituric acid; Medicine; Internal medicine; Endocrinology; Endurance training; Physical exercise; Lipid profile

2026-01-01https://doi.org/10.1590/s0004-2803.24612025-086Arquivos de Gastroenterologia 20261Vulnerabilidade social e habilidades linguísticasGustavo Henrique das Chagas Moura; Mercedes Marcilese

2026-01-26https://doi.org/10.5281/zenodo.18380452Zenodo (CERN European Organization for Nuclear Research)

20261Amamentação associada com Buzzy® para manejo da dor durante vacinação infantil: ensaio clínicoRESUMO Objetivo: avaliar o efeito da amamentação associada à crioterapia com o dispositivo vibratório Buzzy® na redução da dor de lactentes durante a aplicação da vacina pentavalente. Método: ensaio clínico randomizado realizado em setor de vacinação de um município de Minas Gerais, Brasil, entre maio e novembro de 2023. Participaram 62 lactentes, com idades entre 2 e 12 meses, alocados aleatória e igualitariamente em dois grupos: controle (rotina institucional) e experimental (amamentação associada à crioterapia com Buzzy®). Durante a aplicação da vacina, avaliou-se a dor pela Neonatal Infant Pain Scale e tempo de choro. Submeteram-se os dados à análise descritiva e inferencial. Resultados: no grupo controle, todos os lactentes apresentaram escore de dor ≥4, com média de 6,5 pontos na escala, caracterizando presença de dor moderada a intensa e 29,1% dos lactentes choraram por mais de 46 segundos. No grupo experimental, 57,6% obtiveram escore ≥4, com média de 3,7, e 90,9% choraram por menos de 30 segundos, evidenciando redução significativa da dor (p < 0,001). Conclusão: a amamentação associada à crioterapia com Buzzy® se mostrou eficaz no manejo da dor, podendo contribuir para uma prática de vacinação infantil menos dolorosa. Há necessidade de capacitação dos profissionais e participação ativa da mãe/família.Tayene de Oliveira Souza; Luana Vieira Toledo; Luciene Muniz Braga; Hérica Silva Dutra; Suellen Cristina Dias Emídio; Nathalia de Oliveira Martins; Nicacia Cristina Cunha Costa; Paula Krempser

Infant nutrition; Breast feeding; Statistical analysis; Medicine

2026-01-01https://doi.org/10.1590/1983-1447.2026.20250228.ptRevista gaúcha de enfermagem 20261Chromium-Doped Magnetite Nanoparticles for Permanganate Ion Removal: Advances in Environmental RemediationHigh Resolution Image Download MS PowerPoint Slide Iron mines with manganese contamination, as well as manganese mines, are found in various locations worldwide. During manganese ore extraction, permanganate ions (MnO 4 – ) are released into water bodies, imparting an intense purple coloration that reduces light penetration, which can disrupt photosynthetic processes and negatively impact aquatic life. Additionally, their cytotoxic properties pose severe environmental and health risks. This study investigates the adsorption of MnO 4 – onto Cr-doped magnetite nanoparticles (Cr-MNPs) as a potential remediation strategy for contaminated aqueous environments. Cr-MNPs and undoped magnetite nanoparticles were synthesized via the coprecipitation method and characterized using powder X-ray diffraction (XRD), revealing the presence of partially oxidized magnetite phases. X-ray photoelectron spectroscopy (XPS) analysis confirmed the high surface chemical purity of the materials, the presence of trivalent chromium at low concentrations, and the preservation of mixed Fe 2+ /Fe 3+ surface species characteristic of magnetite, while revealing sample-dependent variations in surface oxygen species rather than a systematic increase in surface hydroxylation upon chromium incorporation. The adsorption process was evaluated by analyzing the effects of adsorbent dosage, contact time, and initial MnO 4 – concentration, along with kinetic and isotherm modeling. Equilibrium was reached within 100 min, and experimental data were best described by the pseudo-second-order kinetic model and the Langmuir isotherm, indicating monolayer adsorption on a homogeneous surface. These findings demonstrate that Cr-MNPs are a promising adsorbent for MnO 4 – removal, offering an efficient and sustainable solution for mitigating manganese contamination in aquatic environments, achieving a removal capacity of up to approximately 41 mg g –1 .Daniel de Lima Silva; Rubens Lucas de Freitas Filho; André E. Nogueira; Juliana da Fonseca Alves; Luiz Fernando Cappa de Oliveira; Guilherme Jorge Brigolini Silva; Rodrigo S. de Souza Corrêa; Adilson C. Silva; Ângela Leão Andrade

Adsorption; Permanganate; Magnetite; Environmental remediation; Manganese; Chromium; Aqueous solution; Nanoparticle; Iron oxide; Chemistry; Inorganic chemistry; Chemical engineering; Langmuir adsorption model; Water treatment; Coprecipitation; X-ray photoelectron spectroscopy; Hematite; Materials science; Monolayer; Metal ions in aqueous solution

2026-05-18https://doi.org/10.1021/acsomega.5c12244ACS Omega 20261Amitriptyline for neuropathic pain in patients with leprosy: a bicenter randomized controlled trialABSTRACT: In this bicenter, randomized, double-blind, placebo-controlled trial, we evaluated the effectiveness and safety of amitriptyline as an add-on therapy for leprosy-related neuropathic pain. A total of 117 participants were randomly assigned to receive amitriptyline or placebo for 9 weeks. The primary outcome was the change in pain intensity on a 100-mm visual analogue scale. Secondary outcomes included pain interference, responder rates, neuropathic pain symptoms, mood, sleep, catastrophizing, quality of life, and the Patient Global Impression of Change. No significant differences were observed between treatment arms for the primary end point. Patient Global Impression of Change scores were higher with amitriptyline, and no differences were detected between the other secondary outcomes. Amitriptyline was well-tolerated, and compliance was high in both arms. Treatment-emergent adverse events occurred in 81% of participants analysed in the amitriptyline arm and 94% in the placebo arm, were mostly mild or moderate, and no serious events were reported. A preplanned exploratory analysis examined the effects of therapy on pain phenotypes based on the intensity of spontaneous pain scores (burning, squeezing, and pressure pain). Participants with lower spontaneous pain scores at baseline showed lower pain severity, reduced emotional burden, and better quality-of-life outcomes compared with those with higher scores, regardless of treatment allocation. No significant differences between amitriptyline and placebo were observed within either symptom-defined phenotype. Amitriptyline did not provide superior analgesia compared with placebo when used as add-on therapy for neuropathic pain in people with leprosy. The clinical phenotypic heterogeneity of leprosy-related neuropathic pain may be relevant in future trial designs.Jorge Alberto Martins Pentiado Júnior; Gabriel Taricani Kubota; Larissa Iulle Moreira; Ana Mércia Fernandes; Valquíria Aparecida da Silva; Patrick Raymond Nicolas Andre Ghislain Stump; Dejair Caitano do Nascimento; Lucia Helena Soares Camargo Marciano; Norma Gondim Cléto Nascimento; Jaison Antônio Barreto; Fernanda de Arruda Steffen; Pedro Nascimento Martins; Gil Benard; Maria Angela Bianconcini Trindade; Renato Pazzini; Jefferson Rosi Júnior; Lin Tchia Yeng; Manoel Jacobsen Teixeira; Daniel Ciampi de Andrade

Amitriptyline; Neuropathic pain; Placebo; Randomized controlled trial; Visual analogue scale; Adverse effect; Medicine; Anesthesia; Clinical trial; Physical therapy; Clinical Global Impression; Quality of life (healthcare)

2026-05-18https://doi.org/10.1097/j.pain.0000000000004005Pain 20261The Metabolome of the Ocotea spp.: From Biosynthetic Aspects to Bioactive Chemical Scaffolds by Integrating the Genus Chemical Database ( Ocotea DB)High Resolution Image Download MS PowerPoint Slide The genus Ocotea is a significant source of bioactive agents within the Lauraceae, yet it remains underexplored. Despite its ethnomedicinal relevance and chemical diversity, Ocotea species remain taxonomically challenging as they belong to the multifaceted “Ocotea complex”, a phylogenetically unresolved group. Moving beyond previous literature Ocotea surveys, this review provides the first curated, genus-specific data set of both volatile and nonvolatile specialized metabolites. Covering research articles from 1830 to 2025, this review provides the most comprehensive synthesis to date, documenting 984 unique chemical compounds across 115 species. This effort culminated in the construction of the Ocotea Chemical Database ( Ocotea DB), a novel digital resource created to streamline the genus’s chemical diversity for the global scientific community. Furthermore, it presents current knowledge of biosynthetic routes leading to key bioactive scaffolds, including aporphinoid and benzylisoquinoline alkaloids, lignoids, glycosylated flavonoids, and a diverse array of terpenoids, while addressing the stereochemical and structural intricacies unique to the genus. This review lays a robust foundation to drive future Ocotea -focused bioprospecting studies and guides research in the fields of natural products, chemophenetics, metabolomics, and medicinal chemistry regarding the Ocotea species, its chemical scaffolds, and specialized metabolites.Albert Katchborian-Neto; Karen de Jesus Nicácio; Paula Carolina Pires Bueno; Miller Santos Ferreira; Matheus Fernandes Alves; Daniele de Oliveira Silva; Wanderleya Toledo dos Santos; Marina de Monroe Gonçalves; Ana Claudia Chagas de Paula; Danielle Ferreira Dias; Marisi G. Soares; RuAngelie Edrada-Ebel; João Henrique G. Lago; Daniela Aparecida Chagas-Paula

Bioprospecting; Metabolome; Chemical space; Chemical constituents; Chemical database; chEMBL; Chemical biology; Chemistry; Chemical ecology; Cheminformatics; Key (lock); Biology; Labdane; Genus

2026-05-19https://doi.org/10.1021/acs.jnatprod.5c01567Journal of Natural Products 20261Unveiling the spectroscopy of 2-(nitromethylene)imidazolidine: From experimental findings to theoretical insightsRamon S. da Silva; Laiz R. Ventura; Alexandre E. Santos; Carlos E. Fellows; Elivelton A. Ferreira; Diego P. Sangi

Spectroscopy; Nuclear magnetic resonance spectroscopy; Molecular spectroscopy; Electron spectroscopy; Ultraviolet visible spectroscopy; Chemistry; Nanotechnology

2026-05-19https://doi.org/10.1016/j.saa.2026.128072Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy 20261Factors affecting the carbon capture performance of steel slag and green liquor dregs in direct aqueous carbonationIndustrial alkaline side streams are attractive candidates for carbon capture via carbonation. Slags from steel manufacturing and dregs from the pulp and paper sector are abundant at industrial sites, offering the potential to offset the carbon dioxide emissions of these sectors. For this process to be techno-economically feasible it is crucial to minimize the energy expense while maximizing the carbonation efficiency. In this work, we studied the carbonation capacity of direct reduced iron slag, ladle furnace slag, electric arc furnace slag and green liquor dregs. Direct aqueous carbonation was conducted with a liquid to solid ratio of 20 L/kg and a gas mixture with 15% carbon dioxide and 85% nitrogen. The impact of three operating parameters was investigated: temperature, particle size and stirring of the mixtures prior to carbonation. It was found that for all the materials higher temperature significantly decreased the carbon dioxide uptake, due to the lower solubility of both carbon dioxide and calcium hydroxide in water. Porosity analysis showed that the steel slags have very low porosity on the micropore scale. Thus, the particle size also had a critical impact in the performance, while the effect was less prominent for green liquor dregs. Similarly, stirring the mixtures prior to carbonation allowed better wetting of the materials and lowering of particle size, which also had a positive effect. This study elucidates the impact of key operating parameters in direct aqueous carbonation with two types of industrial side-streams, and highlights the mechanisms through which they affect the carbonation process. • Temperature and particle size influence the carbon dioxide absorption capacity. • Particle size and stirring are beneficial for steel slags with low microporosity. • Increased temperature worsened carbonation due to the reduced solubility.Eduarda C. Queiroz; Emmanouela Leventaki; Alexandre Cuin; Björn Haase; Christian Kugge; Diana Bernin

Carbonation; Aqueous solution; Carbon fibers; Slag (welding); Carbon steel; Metallurgy; Waste management; Environmental science; Materials science; Pulp and paper industry

2026-05-19https://doi.org/10.1016/j.jcou.2026.103441Journal of CO2 Utilization 20261Progress Curves and Stagnation Plateaus: How Administrative Fragility Conditions Educational Indicators in The Lower AmazonAmazonian municipalities demonstrate a low rate of conversion from public resources into sustainable learning gains. The standard explanation, fiscal scarcity and historical legacies, treats local governments as mere passive conduits, overlooking what occurs inside the administrative "black box." This study argues that institutional coordination capacity, that is, the ability to align transportation, infrastructure, nutrition, and pedagogy into a coherent system, mediates the relationship between public investment and educational outcomes. It probes a theoretical proposition by examining the evolution of the FIRJAN Municipal Development Index (Education) in Alenquer, Pará, between 2005 and 2018. Polynomial regression was applied to secondary data. The quadratic model captures curvatures in the trajectory that a linear analysis would flatten. The advance from 0.36 (low level) to 0.74 (medium level) conceals contractions between 2009 and 2010, as well as a deceleration after 2013. These patterns coincide with administrative discontinuities and reductions in intergovernmental transfers. Diminishing returns indicate that resources exist, yet learning does not keep pace. Thus, the analysis shifts from budget to organizational coherence. The study reveals previously implicit causalities, though it recommends caution in generalization. Future research should extend the model's external validity.Clinelza Aires de Araújo; Marco A. Oliveira Santos; Francisco Igo Leite Soares; Kelsiane de Medeiros Lima; Nara Raimunda de Almeida Santos

Fragility; Investment (military); Classification of discontinuities; Public finance; Index (typography); Quadratic equation; Control (management); Public investment; Proposition; Economics; Public economics; Amazon rainforest; Per capita; Political science; Scarcity; Regression analysis; Poverty; Institutional analysis; Per capita income; Sustainable development

2026-05-19https://doi.org/10.5296/jse.v16i2.23723Journal of Studies in Education 20261Avaliação dos conhecimentos e ações em saúde bucal de agentes comunitários de saúde vinculados à Estratégia Saúde da Família do município de Rio Grande (RS)Introdução: O objetivo deste estudo foi avaliar os conhecimentos e as ações em saúde bucal de Agentes Comunitários de Saúde (ACS) de equipes de Saúde da Família (eSF) no Município de Rio Grande (RS). Métodos: O estudo teve delineamento transversal e os dados foram coletados em novembro de 2023, por meio da aplicação de um questionário contendo perguntas sobre características sociodemográficas, ocupacionais, ações e conhecimentos dos ACS de saúde bucal. Participaram 162 ACS, representando 89,5% do total do município, sendo 116 deles vinculados à eSF com equipe de Saúde Bucal (eSB). Resultados: Os resultados demonstraram que 58,6% dos ACS obtiveram pontuação acima da média com relação aos conhecimentos, sem diferenças significativas quanto às variáveis sociodemográficas e ocupacionais. Pouco mais de um terço dos ACS (35,8%) realiza ações de saúde bucal no território, e este grupo foi responsável pela maior proporção com pontuação de conhecimentos acima da média. Dificuldades conceituais importantes acerca dos principais fatores de risco para desenvolver cárie e a baixa porcentagem de ACS que realizam ações em saúde bucal foram identificadas neste estudo. Conclusões: Os achados fornecem novas perspectivas a serem consideradas por gestores e profissionais responsáveis pela educação permanente em saúde bucal dos ACS.Marcia Regina Nunes Marasciulo; Elaine Tomasi; Mabel Miluska Suca Salas; Camila Irigonhé Ramos

Oral health; Oral cavity; Clinical Practice; Periodontal disease; Political science; Medicine; Gynecology; Humanities; Dentistry

2026-05-19https://doi.org/10.5712/rbmfc21(48)4589Revista Brasileira de Medicina de Família e Comunidade 20261USO DA DAPAGLIFOZINA (FORXIGA) NO TRATAMENTO DA INSUFICIÊNCIA CARDÍACA: EVIDÊNCIAS ATUAIS E EFICÁCIA CLÍNICAA insuficiência cardíaca permanece como uma das principais causas de morbimortalidade cardiovascular no mundo, associando-se a elevadas taxas de hospitalização, piora funcional progressiva e importante impacto socioeconômico. Nesse contexto, a dapagliflozina, inibidor do cotransportador sódio-glicose tipo 2 (SGLT2), emergiu como estratégia terapêutica relevante no manejo contemporâneo da insuficiência cardíaca, demonstrando benefícios cardiovasculares e cardiorrenais que extrapolam o controle glicêmico. O presente estudo teve como objetivo analisar as evidências científicas atuais acerca da eficácia clínica da dapagliflozina no tratamento da insuficiência cardíaca, enfatizando seus efeitos sobre mortalidade cardiovascular, hospitalizações, qualidade de vida, capacidade funcional e proteção renal. Trata-se de uma revisão integrativa da literatura, de abordagem qualitativa e caráter descritivo, realizada por meio de buscas nas bases PubMed, SciELO e ScienceDirect, utilizando descritores relacionados à dapagliflozina, insuficiência cardíaca e desfechos cardiovasculares. Foram incluídos estudos publicados entre 2019 e 2023, incluindo ensaios clínicos randomizados, revisões sistemáticas, meta-análises e diretrizes internacionais. Os principais achados evidenciaram redução significativa de hospitalizações por insuficiência cardíaca, mortalidade cardiovascular e episódios de descompensação clínica, além de melhora da qualidade de vida e preservação da função renal em diferentes fenótipos da doença. Destacaram-se especialmente os estudos DAPA-HF e DELIVER, considerados marcos na consolidação dos inibidores de SGLT2 como componente terapêutico fundamental na insuficiência cardíaca. Conclui-se que a dapagliflozina representa avanço importante no tratamento da insuficiência cardíaca, promovendo benefícios clínicos consistentes e contribuindo para uma abordagem terapêutica mais integrada, multidimensional e voltada à otimização dos desfechos cardiovasculares e cardiorrenais.Júlia Chermont Crema; Alessandra Matsuoka Borges da Silva; Ana Paula Schonarth; Kelen Marques de Souza; Fernanda Dominique de Souza Gonçalves; Felipe Veiga Kezam Gabriel; Suzielly Ramos Barbosa Lima Xavier; Luigi Mestrinelli Santiago; Gardênia Santos Pereira; Felipe Romão Hatisuka; Vitor de Castro Ramos; Áureo Nios de Oliveira Sousa; Renato Saraiva da Silva; Larisse Bernardi Simplício; Leôncio Pinheiro Pereira; Michell Ícaro Lima Oliveira; Linaldo Serafim; Ygor Torres Pinto; Daniella Rodrigues Alves; Isabela Godoy Santos; Rosane Cristina de Araújo Portes Paiva; Pedro Henrique Souza e Silva

Quality of life (healthcare); Quality (philosophy); MEDLINE; Randomized controlled trial; Medicine; Gynecology

2026-05-19https://doi.org/10.56238/iimedcientifica-023 20261USO DA DAPAGLIFOZINA (FORXIGA) NO TRATAMENTO DA INSUFICIÊNCIA CARDÍACA: EVIDÊNCIAS ATUAIS E EFICÁCIA CLÍNICAA insuficiência cardíaca permanece como uma das principais causas de morbimortalidade cardiovascular no mundo, associando-se a elevadas taxas de hospitalização, piora funcional progressiva e importante impacto socioeconômico. Nesse contexto, a dapagliflozina, inibidor do cotransportador sódio-glicose tipo 2 (SGLT2), emergiu como estratégia terapêutica relevante no manejo contemporâneo da insuficiência cardíaca, demonstrando benefícios cardiovasculares e cardiorrenais que extrapolam o controle glicêmico. O presente estudo teve como objetivo analisar as evidências científicas atuais acerca da eficácia clínica da dapagliflozina no tratamento da insuficiência cardíaca, enfatizando seus efeitos sobre mortalidade cardiovascular, hospitalizações, qualidade de vida, capacidade funcional e proteção renal. Trata-se de uma revisão integrativa da literatura, de abordagem qualitativa e caráter descritivo, realizada por meio de buscas nas bases PubMed, SciELO e ScienceDirect, utilizando descritores relacionados à dapagliflozina, insuficiência cardíaca e desfechos cardiovasculares. Foram incluídos estudos publicados entre 2019 e 2023, incluindo ensaios clínicos randomizados, revisões sistemáticas, meta-análises e diretrizes internacionais. Os principais achados evidenciaram redução significativa de hospitalizações por insuficiência cardíaca, mortalidade cardiovascular e episódios de descompensação clínica, além de melhora da qualidade de vida e preservação da função renal em diferentes fenótipos da doença. Destacaram-se especialmente os estudos DAPA-HF e DELIVER, considerados marcos na consolidação dos inibidores de SGLT2 como componente terapêutico fundamental na insuficiência cardíaca. Conclui-se que a dapagliflozina representa avanço importante no tratamento da insuficiência cardíaca, promovendo benefícios clínicos consistentes e contribuindo para uma abordagem terapêutica mais integrada, multidimensional e voltada à otimização dos desfechos cardiovasculares e cardiorrenais.Júlia Chermont Crema; Alessandra Matsuoka Borges da Silva; Ana Paula Schonarth; Kelen Marques de Souza; Fernanda Dominique de Souza Gonçalves; Felipe Veiga Kezam Gabriel; Suzielly Ramos Barbosa Lima Xavier; Luigi Mestrinelli Santiago; Gardênia Santos Pereira; Felipe Romão Hatisuka; Vitor de Castro Ramos; Áureo Nios de Oliveira Sousa; Renato Saraiva da Silva; Larisse Bernardi Simplício; Leôncio Pinheiro Pereira; Michell Ícaro Lima Oliveira; Linaldo Serafim; Ygor Torres Pinto; Daniella Rodrigues Alves; Isabela Godoy Santos; Rosane Cristina de Araújo Portes Paiva; Pedro Henrique Souza e Silva

Quality of life (healthcare); Quality (philosophy); MEDLINE; Randomized controlled trial; Medicine; Gynecology

2026-05-19https://doi.org/10.56238/levv17n60-040LUMEN ET VIRTUS 20261Lipid Droplets, ApoE, and Inflammatory Disease StatesRossana C. N. Melo; Peter F. Weller

Disease; Inflammation; Immune system; Pathogenesis; Identification (biology); Medicine; Immunology

2026-01-01https://doi.org/10.1007/978-3-031-96089-5_36 20261Bone Changes in the Temporomandibular Joint: A Retrospective Cone Beam Computed Tomography StudyObjectives: To analyze the prevalence of bone changes in the temporomandibular joint (TMJ) and describe their distribution regarding age and sex using Cone Beam Computed Tomography (CBCT). Methods: This retrospective study analyzed CBCT images of 483 individuals (326 females, 157 males) retrieved from a computer database and assessed using the iCAT Workstation. Right and left condyles were evaluated for the presence of flattening, osteophytes, sclerosis, erosion, and subchondral cysts. Pearson’s chi-square test was used to identify potential associations between these alterations and demographic variables (p < 0.05). Results: At least one TMJ alteration was observed in 91.5% of the participants. Flattening was the most frequent finding (76.4%), followed by osteophytes (53%), sclerosis (32.3%), erosion (20.1%), and subchondral cysts (2.7%). No statistically significant association was found between gender and the presence of alterations (p > 0.05), with a high prevalence in both females (91.1%) and males (92.4%). However, specific degenerative changes showed a significant upward trend with age: osteophytes increased from 43.9% in patients under 20 to 68.9% in those over 60, while erosion doubled from 12.2% to 24.4% in the same groups (p < 0.05). Alterations were slightly more frequent on the left side (81.6%) than on the right side (76.6%). Conclusions: Degenerative TMJ changes are highly prevalent in the studied population, with flattening appearing as a widespread finding across all groups. While some specific alterations, such as osteophytes and erosion, show an increased prevalence in older age groups, these associations reflect a descriptive trend of bone remodeling over time rather than a direct causal relationship.Daniela Pereira Urgal; Carolina Oliveira De Lima; João Víctor Frazão Câmara; Isabel Ferreira Barbosa; Maíra Prado; Celso Neiva Campos

Cone beam computed tomography; Condyle; Temporomandibular joint; Subchondral bone; Retrospective cohort study; Computed tomography; Correlation; Tomography; Medicine; Orthodontics; Dentistry; Radiology; Osteoarthritis; Flattening; Nuclear medicine

2026-05-20https://doi.org/10.3390/dj14050313Dentistry Journal 20261Slave Labor and the Determination of Wages in BrazilLuiz Fernando Saraiva; Elione Silva Guimarães

Wage; Work (physics); Real wages; Productivity; Production (economics); Economics; Labour economics

2026-01-01https://doi.org/10.1007/978-3-031-91930-5_13Palgrave studies in economic history 20261HydroAir: An Air-Propelled Surface Vehicle for Autonomous Navigation and 3D Reconstruction in Shallow and Obstacle-Rich Aquatic EnvironmentsThis paper presents HydroAir, a novel air-propelled Unmanned Surface Vehicle (USV) specifically designed for operation in shallow waters and obstacle-rich aquatic environments such as lakes, reservoirs, and large dams. Unlike conventional aquatic robots, HydroAir employs an aerial propulsion system that enables it to overcome partially submerged obstacles, vegetation, and extremely shallow regions where traditional propeller-based platforms fail. The vehicle features a system with a very reliable internal architecture, providing high maneuverability and robustness in both manual and autonomous navigation modes. The primary objective of HydroAir is to serve as a mobile sensing platform for three-dimensional reconstruction of aquatic environments, particularly the underwater terrain. The onboard sensing suite enables bathymetric data acquisition, while a dedicated monitoring and control software integrates these data with aerial reconstructions obtained from Unmanned Aerial Vehicles (UAVs), allowing for the fusion of above-water and underwater spatial information into a unified 3D model. Experimental validations were conducted in large-scale, real-world environments, including tests in a hydroelectric dam operated by Santo Antônio Energia on the Madeira River in Brazil, demonstrating the platform's operational feasibility, stability, and reconstruction capabilities. The results indicate that HydroAir is a promising solution for environmental monitoring, inspection, and mapping in challenging aquatic environments where conventional autonomous surface vehicles are limited.Leonardo de Mello Honório; V. F. Vidal; Iago Z. Biundini; Rodolfo Almeida Machado; Felippe Fernandes; M. F. Santos

Bathymetry; Underwater; Photogrammetry; Robustness (evolution); Remotely operated underwater vehicle; Suite; 3D reconstruction; Software; Propulsion; Remote sensing; Marine engineering; Computer science; Unmanned surface vehicle; Environmental science; Sensor fusion; Aquatic environment; Python (programming language); Environmental monitoring; Engineering; Waves and shallow water; Remotely operated vehicle; Real-time computing; Mobile robot

2026-05-20https://doi.org/10.3390/s26103225Sensors 20261A SPARC test of a cosmologically anchored galactic transition scale in Spacetime Densification TheoryAbstract The radial acceleration relation (RAR) of disk galaxies shows that the observed centripetal acceleration is tightly correlated with the Newtonian acceleration generated by the baryonic mass distribution, with a characteristic transition scale . The origin of this scale, and its numerical proximity to cosmological accelerations of order , remains an open problem. Spacetime Densification Theory (SDT) associates the homogeneous vacuum sector with a cosmologically calibrated cohesive acceleration scale, , fixed by Planck 2018 cosmological parameters. In the galactic regime, the transition acceleration is written as , where is a dimensionless factor encoding the nonlinear response of the substrate. We test this cosmologically anchored transition-scale hypothesis on the Spitzer Photometry and Accurate Rotation Curves (SPARC) database using the algebraic SDT closure , with . The analysis is applied to a quality-controlled sample of 133 disk galaxies, comprising 2696 radial points, with stellar mass-to-light ratios treated as galaxy-level nuisance parameters under stellar-population-synthesis priors. We perform two complementary tests: a fixed-target test with , corresponding to the empirical mapping , and a global-inference test in which a single is fitted simultaneously across all galaxies. The global acceleration-space fit yields , corresponding to , approximately 5.8% above the cosmologically anchored target. A complementary velocity-space rerun gives , approximately 3.8% below the target, so that the two likelihood choices bracket the cosmological value at the few-percent level. The rms residual in is 0.087 dex, with negligible mean bias and no significant residual trend with baryonic acceleration. A same-pipeline comparison with baryons-only Newtonian dynamics and MOND with the simple interpolating function shows that SDT and MOND provide statistically comparable RAR-level descriptions of the SPARC sample, whereas the Newtonian baseline is strongly excluded. These results indicate that the SPARC RAR is consistent with a single global SDT transition factor anchored to the cosmological cohesive scale, with performance comparable to canonical MOND. The analysis does not constitute a first-principles derivation of ; rather, it tests its universality and numerical value as a falsifiable hypothesis. Keywords: galaxies: kinematics and dynamics — galaxies: spiral — gravitation — dark matter — methods: data analysis — methods: statistical.Paulo G.A. Suassuna

Galaxy rotation curve; Dark matter; Acceleration; Galaxy; Dimensionless quantity; Cosmological constant; Modified Newtonian dynamics; Baryon; Cosmology; Physics; Astrophysics; Newtonian dynamics; Trispectrum; Dark energy; Classical mechanics; Planck; Scale factor (cosmology); Dynamical friction

2026-05-21https://doi.org/10.5281/zenodo.20328441Zenodo (CERN European Organization for Nuclear Research) 20261Comprehensive analysis of proposed legislation regarding associated traditional knowledge in Brazil: 1988-2022This article analyses how the Brazilian House of Representatives addressed, between 1988 and 2022, bills relating to associated traditional knowledge, genetic heritage, and the rights of traditional peoples and communities. The research problem is to understand which legislative proposals were introduced during this period, which rights they sought to regulate, and how they were handled legislatively. The study aims to map and examine these proposals, identify their legislative status in 2024, and construct analytical categories concerning their main regulatory axes. The research adopts a qualitative documentary approach, analysing 71 bills through Grounded Theory, operationalised by means of microanalysis of the legal provisions and axial coding for the formation of broader categories. Of the total, 32 bills have been archived, 36 remain under consideration, and 3 have been enacted into law. Categories identified include ownership and management of territories, rules of access, rights, obligations and conditions of use, as well as benefit-sharing. It is concluded that the legislative agenda analysed reproduces regulatory patterns rooted in a colonial matrix by subordinating traditional knowledge to state forms of control and by allowing, in specific situations, access without prior informed consent, thereby revealing power asymmetries in the regulation of these rights.Pedro Henrique Oliveira Cuco; Vanessa Ferreira Lopes; Maria Alice Chaves Nunes Costa; Marcos Vinício Chein Feres

Legislature; Legislation; Construct (python library); Control (management); State (computer science); Power (physics); Political science; Public administration; Public relations; Law and economics; Law; Sociology; Qualitative research; Action (physics)

2026-05-04https://doi.org/10.7213/rev.dir.econ.soc.v17i2.32755Revista de Direito Econômico e Socioambiental 20261School attendance in individuals with cerebral palsy in BrazilAbstract Aim To identify factors associated with school attendance among Brazilian children, adolescents, and young adults with cerebral palsy (CP) using population‐based data from the Brazilian Cerebral Palsy Register (BrCPR). Method This cross‐sectional study analysed data from 774 individuals aged 4 to 21 years with CP registered in the BrCPR. Variables included sociodemographic and clinical characteristics (Gross Motor Function Classification System, Manual Ability Classification System, and speech limitations), and school attendance. Descriptive and bivariate analyses were conducted using χ 2 tests; multivariable logistic regression models were applied to estimate adjusted odds ratios (aORs) with corresponding 95% confidence intervals (CIs). Results Among participants, 76% attended school, although 62% could not read and write. Adolescents with CP aged 13 to 21 years were less likely to attend school compared to those aged 4 to 12 years (aOR = 0.49, 95% CI = 0.3–0.7), as were those classified in Gross Motor Function Classification System levels IV and V compared to levels I to III (aOR = 0.29, 95% CI = 0.1–0.4). Additionally, the presence of speech limitations was associated with reduced school attendance (aOR = 0.12, 95% CI = 0.1–0.3). Interpretation Although school attendance rates for Brazilian individuals with CP are relatively high compared to other low‐ and middle‐income countries, major barriers persist. Addressing speech support, and mobility‐related inclusion, is essential to improve both school attendance and meaningful involvement.Ricardo Rodrigues de Sousa; Luana Cristina da Silva; Ana Cristina Resende Camargos; Eliane Beatriz Cunha Policiano; Lívia Ferreira Coutinho Alonso; Nadia Badawi; Israt Jahan; Gulam Khandaker; María de las Mercedes Ruiz Brünner; Paula Silva de Carvalho Chagas; Hércules Ribeiro Leite

Cerebral palsy; Attendance; Logistic regression; Odds ratio; Bivariate analysis; Confidence interval; Medicine; Odds; Gross Motor Function Classification System; Demography; Physical therapy; Descriptive statistics; Psychology

2026-05-21https://doi.org/10.1111/dmcn.70316Developmental Medicine & Child Neurology 20261Spacetime Densification Theory and the Newtonian limitAbstract We develop an effective scalar-field theory for a coherent spacetime substrate whose long-wavelength response reproduces Newtonian gravity. The substrate is represented at macroscopic scales by a scalar density field coupled universally to standard matter through an effective metric whose leading conformal sector generates the Newtonian limit and whose disformal sector defines higher-gradient viability constraints, . The microscopic equation of state of the substrate is taken from companion work and is not derived here. We obtain the linearized field equation for the density perturbation around a homogeneous background, identify a Poisson-like source law , and show that the gradient of the substrate density acts on matter through an effective force . The Newtonian limit is recovered exactly when the two response coefficients satisfy the calibration condition . A benchmark thermodynamic closure for maps these coefficients to substrate parameters, reducing the calibration to a constraint on one microscopic combination rather than an arbitrary split of . The tensorial Einstein–Hilbert sector is not derived, but imposed as an infrared matching condition required for relativistic consistency. We formulate the matching prescription that prevents double counting: the densification potential and the infrared Newtonian potential are identified as the same object, not additive. Disformal and higher-derivative corrections, together with post-Newtonian and multi-messenger constraints, are characterized as viability conditions on the effective parameter space rather than as derived predictions. No claims are made in this paper concerning post-Newtonian observables, gravitational waves, galactic phenomenology, or strong-field dynamics; these are deferred to companion work. Keywords: emergent gravity; effective field theory; disformal coupling; Newtonian limit; induced gravity; infrared matching; scalar–tensor theories.Paulo G.A. Suassuna

Newtonian limit; Newtonian fluid; Spacetime; Scalar field; Newtonian potential; Scalar (mathematics); Gravitation; Linearized gravity; Gravitational field; Physics; Classical mechanics; General relativity; Field (mathematics); Perturbation theory (quantum mechanics); Effective field theory; Limit (mathematics); Kinetic term; Conformal map; Parameter space

2026-05-21https://doi.org/10.5281/zenodo.20328312Zenodo (CERN European Organization for Nuclear Research) 20261An Equation of State for Spacetime Densification Theory in the Strong-Field Regime: Toward a Unified Description of Compact-Object Critical Masses and Black-Hole FormationSpacetime Densification Theory (SDT) describes gravitation as the macroscopic manifestation of a discrete and saturable spacetime substrate composed of fundamental excitations termed spaceons. While the cosmological and galactic sectors of SDT have been developed in detail, its strong-field regime remains underspecified. In this work, we propose an operational equation of state (EOS) for SDT applicable to compact-object critical masses and black-hole formation, integrating the hadronic, quark, and spaceon sectors into a coupled three-component formulation. We introduce a constitutive coupling between baryonic energy density and the local spaceon density, activated at the hadron–quark transition through a smooth tanh window function and parametrized through an exponential saturation form that interpolates smoothly between linear onset and bounded asymptotic response. The activation scale is set by the deconfinement transition energy density rather than by the saturation density itself, thereby ensuring a physically meaningful substrate response in the compact-object regime. We examine the causal structure of the spaceon EOS through explicit numerical evaluation of the substrate sound speed within a representative parametric domain (Appendix A), and show that the requirement of subluminal propagation provides a non-trivial upper bound on the matter–substrate coupling parameter, demonstrating that the operational closure is internally self-regulating. The resulting modified Tolman–Oppenheimer–Volkoff (TOV-SDT) system extends classical hydrostatic equilibrium by incorporating a density-dependent effective gravitational coupling and an additional substrate pressure that becomes incompressible as the spaceon density approaches saturation. We provide an explicit single-step integration algorithm for the coupled hydrostatic system, define the construction of the SDT mass–central-density equilibrium sequence, and formulate the radial-stability criterion that locates the turning point dM/dεc = 0 of the SDT branch. The framework is constructed so as to remain compatible in principle with the main strong-field observational anchors—including the NICER mass–radius measurements of PSR J0740+6620, the GW170817 tidal-deformability bounds, GW190814, the EHT shadow observations, and the GW250114 ringdown spectroscopy. A parametric scaling estimate of the SDT critical mass yields McSDT ≈ 2.5–3.0 M⊙ for nominal parameter choices, opening a physically plausible stability window in the GW190814 mass range. Five falsifiable observational predictions are derived. The framework is presented as an algebraic constitutive closure of a more fundamental scalar–tensor strong-field SDT system whose full dynamical formulation is left to future work; an explicit roadmap toward the rotating axisymmetric extension and a Teukolsky-type perturbative formalism is outlined.Paulo G.A. Suassuna

Spacetime; Dissipative system; Gravitation; Bounded function; Hydrostatic equilibrium; Equation of state; Compressibility; Gravitational collapse; Physics; Classical mechanics; Dissipation; Statistical physics; Singularity; Parametric statistics; Coupling (piping); State variable

2026-05-05https://doi.org/10.5281/zenodo.20039620Zenodo (CERN European Organization for Nuclear Research) 20261Primary Sclerosing Cholangitis Recurrence After Liver Transplantation: A Systematic Review and Updated Meta‐AnalysisABSTRACT Background and Aims Primary sclerosing cholangitis (PSC) is an immune‐mediated cholestatic liver disease. Liver transplantation (LT) remains the only definitive treatment for patients with advanced disease. However, recurrence of PSC (rPSC) after LT is still a significant clinical challenge. The aim of this study was to assess the prevalence and incidence of rPSC following transplantation and to identify factors associated with its occurrence. Methods We conducted a systematic review and meta‐analysis of observational cohorts by searching PubMed, Embase and Cochrane for studies. Statistical analyses were conducted using R, applying a random‐effects model with 95% confidence intervals. Results Twenty‐nine studies were included, comprising 4682 patients who underwent LT for PSC (63.7% male). Most data originated from Europe (51.7%) and North America (29.2%), with additional cohorts from Asia (13.7%), South America (2.8%) and Oceania (2.6%). The worldwide pooled prevalence of rPSC was 18.66% (95% CI 15.33–22.52; I 2 = 84%) between 1980 and 2024. As for the worldwide pooled incidence, rPSC occurred at 26.04 per 1000 person‐years (95% CI 19.30–32.78; I 2 = 76.1%). The continent with the highest rPSC prevalence was Oceania with 30.65% (95% CI 23.17–39.29; I 2 = 13.8%) and South America had the highest incidence with 39.97 per 1000 person‐years (95% CI 25.42–54.51). Younger recipient age (mean difference [MD] = 5.16 years, 95% CI 4.13–6.19; I 2 = 51.3%), male sex (risk ratio [RR] = 0.92, 95% CI 0.87–0.98; I 2 = 0%), post‐LT cyclosporine use (RR = 0.56, 95% CI 0.42–0.76; I 2 = 0%), acute rejection (RR = 0.64, 95% CI 0.49–0.83) and de novo IBD (RR = 0.63, 95% CI 0.40–0.99; I 2 = 0%) were associated with an increased risk of recurrence. Conclusions Prevalence and incidence of rPSC post‐LT varied according to continents. Younger recipient age, male sex, de novo IBD, cyclosporine use post‐LT and acute rejection episodes were associated with a higher risk of recurrence. Trial Registration PROSPERO ID: CRD420250645485Isabelle Castro Vitor; Milena Ramos Tomé; Wellgner Fernandes Oliveira Amador; Igor Boechat Silveira; Marina de Assis Bezerra Cavalcanti Leite; Pedro Robson Costa Passos; Valbert Oliveira Costa Filho; Mariana Macambira Noronha; Yohanna Idsabella Rossi; Guilherme Grossi Lopes Cançado; Rodrigo Vieira Motta

Primary sclerosing cholangitis; Liver transplantation; Incidence (geometry); Confidence interval; Observational study; Meta-analysis; Cohort study; Cohort; Medicine; Internal medicine; Gastroenterology; MEDLINE; Odds ratio; Transplantation

2026-05-21https://doi.org/10.1111/liv.70673Liver International 20261A hard-core lattice-gas model of the cosmological vacuum: thermodynamics, equation of state, and cohesive calibration to 𝛀𝚲Abstract We construct an effective statistical-mechanical model of the cosmological vacuum based on a hard-core bosonic lattice gas defined on a discrete substrate. Each elementary cell of volume may host at most one excitation, producing a finite saturation density . From the grand canonical ensemble we derive a homogeneous equation of state combining a configurational packing pressure, which diverges as , with a low-density cohesive contribution controlled by a single coupling . In the cosmological branch , the equation of state reduces to , corresponding to an effective vacuum-energy density and equation-of-state parameter . Identifying the effective fluctuation temperature with the Gibbons–Hawking temperature of the asymptotic de Sitter background suppresses the packing contribution by a factor of order . Calibrating to the observed dark-energy density fixes , yielding for Planck 2018 parameters. The construction matches the homogeneous dark-energy sector of CDM once the cohesive coupling is calibrated to the observed vacuum-energy density, and provides a statistical-mechanical saturation ceiling for the substrate density. No gravitational dynamics is derived here; the paper is self-contained as a thermodynamic and statistical-mechanical proposal for the cosmological vacuum sector. Keywords: discrete spacetime; emergent vacuum; equation of state; lattice gas; hard-core bosons; cosmological constant problem; dark energy.Paulo G.A. Suassuna

Equation of state; Cosmological constant; De Sitter universe; Lattice (music); Cosmology; Homogeneous; Coupling (piping); Entropy (arrow of time); Thermodynamic potential; Physics; Statistical physics; Coupling constant; Planck; Mathematical physics; Ground state; Saturation (graph theory); Kinetic energy

2026-05-21https://doi.org/10.5281/zenodo.20328074Zenodo (CERN European Organization for Nuclear Research) 20261From Active Methods to Value Co-Creation Pedagogy: A Layered Framework for Management and Entrepreneurship EducationCristina Sayuri Côrtes Ouchi Dusi; Thiago Gomes de Almeida; Jesús Antonio López Escobedo

Transformative learning; Toolbox; Experiential learning; Entrepreneurship; Value (mathematics); Entrepreneurship education; Management development; Knowledge management; Sociology; Engineering ethics; Higher education; Management science; Innovation management; Experiential education

2026-01-01https://doi.org/10.2139/ssrn.6811762SSRN Electronic Journal 20261El estudio como uso no apropiativo del bien comúnEl orden neoliberal constituye, ciertamente, mucho más que un sistema económico, implica, ante todo, una manera muy específica de entender la relación entre los individuos y el bien común. En el interior del orden neoliberal, esta relación toma la forma de una apropiación privatizante del bien común. En términos educativos, este gesto de apropiación privatizante se verifica en la cristalización del discurso educativo en torno a la noción de aprendizaje, aquello que Biesta (2021) denomina learningification de la educación. Al asumir este gesto apropiativo “el de aprender” como el elemento central del acto educativo, las discusiones referentes al derecho a la educación no consiguen rebasar el horizonte de la justicia distributiva, es decir, el del reparto de lo común entre los privados. En las páginas que siguen proponemos una problematización, tanto del principio de apropiación privatizante como del de justicia distributiva que subyacen en la noción de aprendizaje, y una reivindicación del concepto de estudio en tanto categoría pedagógica fundamental para pensar un uso no apropiativo del bien común.Maximiliano Valerio López

Order (exchange); Context (archaeology); Humanities; Philosophy

2026-05-12https://doi.org/10.19053/uptc.22160159.v17.n48.2026.20484Praxis & Saber 20261A SPARC test of a cosmologically anchored galactic transition scale in Spacetime Densification TheoryAbstract The radial acceleration relation (RAR) of disk galaxies shows that the observed centripetal acceleration is tightly correlated with the Newtonian acceleration generated by the baryonic mass distribution, with a characteristic transition scale . The origin of this scale, and its numerical proximity to cosmological accelerations of order , remains an open problem. Spacetime Densification Theory (SDT) associates the homogeneous vacuum sector with a cosmologically calibrated cohesive acceleration scale, , fixed by Planck 2018 cosmological parameters. In the galactic regime, the transition acceleration is written as , where is a dimensionless factor encoding the nonlinear response of the substrate. We test this cosmologically anchored transition-scale hypothesis on the Spitzer Photometry and Accurate Rotation Curves (SPARC) database using the algebraic SDT closure , with . The analysis is applied to a quality-controlled sample of 133 disk galaxies, comprising 2696 radial points, with stellar mass-to-light ratios treated as galaxy-level nuisance parameters under stellar-population-synthesis priors. We perform two complementary tests: a fixed-target test with , corresponding to the empirical mapping , and a global-inference test in which a single is fitted simultaneously across all galaxies. The global acceleration-space fit yields , corresponding to , approximately 5.8% above the cosmologically anchored target. A complementary velocity-space rerun gives , approximately 3.8% below the target, so that the two likelihood choices bracket the cosmological value at the few-percent level. The rms residual in is 0.087 dex, with negligible mean bias and no significant residual trend with baryonic acceleration. A same-pipeline comparison with baryons-only Newtonian dynamics and MOND with the simple interpolating function shows that SDT and MOND provide statistically comparable RAR-level descriptions of the SPARC sample, whereas the Newtonian baseline is strongly excluded. These results indicate that the SPARC RAR is consistent with a single global SDT transition factor anchored to the cosmological cohesive scale, with performance comparable to canonical MOND. The analysis does not constitute a first-principles derivation of ; rather, it tests its universality and numerical value as a falsifiable hypothesis. Keywords: galaxies: kinematics and dynamics — galaxies: spiral — gravitation — dark matter — methods: data analysis — methods: statistical.Paulo G.A. Suassuna

2026-05-21https://doi.org/10.5281/zenodo.20328440Zenodo (CERN European Organization for Nuclear Research) 20261A hard-core lattice-gas model of the cosmological vacuum: thermodynamics, equation of state, and cohesive calibration to 𝛀𝚲Abstract We construct an effective statistical-mechanical model of the cosmological vacuum based on a hard-core bosonic lattice gas defined on a discrete substrate. Each elementary cell of volume may host at most one excitation, producing a finite saturation density . From the grand canonical ensemble we derive a homogeneous equation of state combining a configurational packing pressure, which diverges as , with a low-density cohesive contribution controlled by a single coupling . In the cosmological branch , the equation of state reduces to , corresponding to an effective vacuum-energy density and equation-of-state parameter . Identifying the effective fluctuation temperature with the Gibbons–Hawking temperature of the asymptotic de Sitter background suppresses the packing contribution by a factor of order . Calibrating to the observed dark-energy density fixes , yielding for Planck 2018 parameters. The construction matches the homogeneous dark-energy sector of CDM once the cohesive coupling is calibrated to the observed vacuum-energy density, and provides a statistical-mechanical saturation ceiling for the substrate density. No gravitational dynamics is derived here; the paper is self-contained as a thermodynamic and statistical-mechanical proposal for the cosmological vacuum sector. Keywords: discrete spacetime; emergent vacuum; equation of state; lattice gas; hard-core bosons; cosmological constant problem; dark energy.Paulo G.A. Suassuna

2026-05-21https://doi.org/10.5281/zenodo.20328075Zenodo (CERN European Organization for Nuclear Research) 20261Incidence and treatment-based risk stratification of opportunistic infections in patients with inflammatory bowel disease: an ambispective cohort study in BrazilBackground/Aims: The risk of opportunistic infections (OIs) in inflammatory bowel disease (IBD) patients in Latin America is poorly known.We assessed the incidence and stratified the risk of OIs in IBD patients on immunosuppressive therapies.Methods: In this ambispective cohort study, we retrospectively analyzed the medical charts of IBD patients between March 2014 and March 2021 and prospectively analyzed those from April 2021 to April 2024.The incidence rate of OIs was expressed as the number per 1,000 patient-years (PY) and calculated for each treatment category.The risks of OIs associated with immunosuppressants were compared with exposure to aminosalicylates or no treatment using the Cox proportional hazards model.Results: In a total of 3,279.6PY of follow-up, OIs occurred in 60 of 498 patients (12.0%) with an incidence rate of 18.3 per 1,000 PY.The most common OIs were herpes zoster (HZ; n = 28, 5.6%) and tuberculosis (n = 17, 3.4%).The incidence rates of HZ and tuberculosis were 8.5 and 5.18 per 1,000 PY, respectively.Compared with patients on aminosalicylates or no treatment, the risk of OIs was higher in those on combination therapies with anti-tumor necrosis factor (TNF) and thiopurines (hazard ratio [HR], 7.67; 95% confidence interval [CI], 2.26-26.06),followed by thiopurine monotherapy (HR, 5.35; 95% CI, 1.56-18.3),and anti-TNF monotherapy (HR, 5.04; 95% CI, 1.50-16.97).Conclusions: IBD patients on long-term anti-TNF and/or thiopurine therapy had a higher risk of OIs, especially HZ and tuberculosis, compared with non-immunosuppressed patients.In the choice of therapies for IBD, the balance of individual drug effectiveness and safety is crucial.(Intest Res,Rios Ricci José Eugenio; Tarsila Campanha da Rocha Ribeiro; Fernando Antônio Basile Colugnati; Lívia de Almeida Costa; Pedro de Morais; Jordana AS Lopes; Hugo B Araújo; Matheus Alves Pacheco; Mariana V de S Paulo; João Fraga; L. Schmidt; Thais de Andrade Almeida; Roberta Oliveira Raimundo Borsato; Liliana Andrade Chebli; Júlio Maria Fonseca Chebli

Thiopurine methyltransferase; Incidence (geometry); Cohort; Inflammatory bowel disease; Cohort study; Tuberculosis; Risk factor; Confidence interval; Medicine; Internal medicine; Proportional hazards model; Ulcerative colitis; Azathioprine; Crohn's disease

2026-05-21https://doi.org/10.5217/ir.2025.00208Intestinal Research 20261Relationships between drive for muscularity, muscularity-oriented eating behaviors, and muscle dysmorphia: A study with cisgender lesbian and bisexual womenIndividuals with Muscle Dysmorphia (MD) exhibit a high drive for muscularity and muscularity-oriented eating behavior. Sexual minorities are also vulnerable to disturbances in body image and eating behavior; however, research on MD in sexual minority women is scarce. Therefore, the present study aimed to propose and evaluate an exploratory theoretical model of MD in Brazilian cisgender lesbian and bisexual women that includes sociodemographic variables (sexual orientation, skin color, BMI, and age), drive for muscularity, and muscularity-oriented eating behaviors. The study included 1131 participants aged 18-50. Structural equation modeling indicated that drive for muscularity and muscularity-oriented eating behaviors were associated with different dimensions of MD symptoms. However, sexual orientation and skin color were not associated with muscularity-related dimensions among lesbians and bisexual women. Younger women were more vulnerable to muscularity-related issues, and BMI had varying associations depending on the construct analyzed. Overall, drive for muscularity and muscularity-oriented eating behaviors were interrelated with MD symptoms in cisgender lesbian and bisexual women. The final refined model demonstrated good fit: χ²(1010) = 8287.982, p < .001; χ²/df = 8.24; CFI = .949; TLI = .954; RMSEA = .080 [90% CI = .078 -.081]. These findings emphasize the importance of assessing drive for muscularity and muscularity-oriented eating behaviors as targets for screening, prevention, and intervention in health care settings.Maria Laura Precinotto; Isabella Maria Fiori Brisotti; Pedro Henrique Berbert de Carvalho; Alessandra Costa Pereira Junqueira; Jason M. Nagata; Emilio J. Compte; Stuart B. Murray; Maria Fernanda Laus

Lesbian; Eating disorders; Young adult; Eating behavior; Ethnically diverse; Self-concept; Psychology; Developmental psychology; Clinical psychology

2026-05-21https://doi.org/10.1016/j.bodyim.2026.102107Body Image 20261Efeitos do programa Bolsa Família sobre a segurança alimentar e nutricionalIntroduction: In Brazil, although adequate food is a social right, it remains unfulfilled for everyone. In this context, the Bolsa Família Program (BFP) is relevant by promoting Food and Nutrition Security (FNS). Objective: To understand the effects of the BFP on FNS from the viewpoint of beneficiary families. Methods: A qualitative-quantitative study was conducted at the Pastoral da Criança (Children's Pastoral) with BFP beneficiaries in Governador Valadares (MG). Questionnaires containing demographic and socioeconomic information, the Brazilian Food Insecurity Scale, and open-ended questions were used. Data were analyzed descriptively through content analysis. Results: The study included 34 beneficiaries from 8 communities, mostly black or mixed-race, with a monthly income of up to two minimum wages. It was observed that 91.2% of the families were experiencing food insecurity. From the 28 interviews, five categories emerged: the destination of financial resources in the families livings; influencers of food choices; foods considered essential; consideration of family nutrition; and changes generated by the BFP. It should be noted that financial resources are primarily allocated to children, that price is the main influencing factor in food choices, that unprocessed and minimally processed foods are considered essential, and that the BFP promotes the autonomy of families. Conclusion: The BFP contributes to improve the nutrition and quality of life of beneficiary families, but does not fully guarantee food and nutrition security. Financial limitations remain an obstacle, making it essential to integrate this program with other public policies to fulfill the right to adequate food.Adria Ketlin Miranda Rodrigues; Jéssica Rodrigues de Oliveira; Natália Cadetti de Souza; Patrícia Aparecida Baumgratz de Paula; Nilcemar Rodrigues Carvalho Cruz; Kellem Regina Rosendo Vincha

Beneficiary; Food security; Influencer marketing; Socioeconomic status; Poverty; Quality (philosophy); Supplemental Nutrition Assistance Program; Nutrition Education; Financial security; Business; Economic growth; Healthy eating; Environmental health; Consumption (sociology); Nutrition transition; Autonomy; Food insecurity

2026-03-30https://doi.org/10.20396/san.v32i00.8678923Segurança Alimentar e Nutricional 20261A Region-Wise-Based Tool for AC Islanded Microgrids Steady-State Security AssessmentThis paper introduces a Static Security Region (SSR)-based method for the analysis of alternating current islanded microgrids, accounting for steady-state voltage and frequency variations, as well as droop control operation. The SSR is a set of two-dimensional graphics with axes representing the summation of power from loads, generation units operating under droop control mode, and Renewable Energy Resources-based generation units (RER). The principal contribution of thiswork is an Optimal Power Flow formulation designed to maximize the distance between the base case and the security border across a defined set of search directions. Comparative analyses conducted on two islanded microgrids reported in the literature show that the proposed method achieves an accuracy similar to traditional techniques, while delivering computational savings ranging from 20% to 65%. In addition, a probabilistic analysis is introduced to quantify the effects of load and RER generation uncertainties - modeled using typical probability distribution functions - on security margins, confirming that greater uncertainty leads to a smaller conservative security margin.Wesley Peres; João Alberto Passos Filho; João Marcos R. Baccarini

Transient analysis; Vulnerability assessment; Key (lock); Control system; Acceleration; Computer science; Reliability engineering; Control engineering

2026-01-01https://doi.org/10.1109/access.2026.3695703IEEE Access 20261An Equation of State for Spacetime Densification Theory in the Strong-Field Regime: Toward a Unified Description of Compact-Object Critical Masses and Black-Hole FormationSpacetime Densification Theory (SDT) describes gravitation as the macroscopic manifestation of a discrete and saturable spacetime substrate composed of fundamental excitations termed spaceons. While the cosmological and galactic sectors of SDT have been developed in detail, its strong-field regime remains underspecified. In this work, we propose an operational equation of state (EOS) for SDT applicable to compact-object critical masses and black-hole formation, integrating the hadronic, quark, and spaceon sectors into a coupled three-component formulation. We introduce a constitutive coupling between baryonic energy density and the local spaceon density, activated at the hadron–quark transition through a smooth tanh window function and parametrized through an exponential saturation form that interpolates smoothly between linear onset and bounded asymptotic response. The activation scale is set by the deconfinement transition energy density rather than by the saturation density itself, thereby ensuring a physically meaningful substrate response in the compact-object regime. We examine the causal structure of the spaceon EOS through explicit numerical evaluation of the substrate sound speed within a representative parametric domain (Appendix A), and show that the requirement of subluminal propagation provides a non-trivial upper bound on the matter–substrate coupling parameter, demonstrating that the operational closure is internally self-regulating. The resulting modified Tolman–Oppenheimer–Volkoff (TOV-SDT) system extends classical hydrostatic equilibrium by incorporating a density-dependent effective gravitational coupling and an additional substrate pressure that becomes incompressible as the spaceon density approaches saturation. We provide an explicit single-step integration algorithm for the coupled hydrostatic system, define the construction of the SDT mass–central-density equilibrium sequence, and formulate the radial-stability criterion that locates the turning point dM/dεc = 0 of the SDT branch. The framework is constructed so as to remain compatible in principle with the main strong-field observational anchors—including the NICER mass–radius measurements of PSR J0740+6620, the GW170817 tidal-deformability bounds, GW190814, the EHT shadow observations, and the GW250114 ringdown spectroscopy. A parametric scaling estimate of the SDT critical mass yields McSDT ≈ 2.5–3.0 M⊙ for nominal parameter choices, opening a physically plausible stability window in the GW190814 mass range. Five falsifiable observational predictions are derived. The framework is presented as an algebraic constitutive closure of a more fundamental scalar–tensor strong-field SDT system whose full dynamical formulation is left to future work; an explicit roadmap toward the rotating axisymmetric extension and a Teukolsky-type perturbative formalism is outlined.Paulo G.A. Suassuna

2026-05-05https://doi.org/10.5281/zenodo.20039621Zenodo (CERN European Organization for Nuclear Research) 20261Spacetime Densification Theory and the Newtonian limitAbstract We develop an effective scalar-field theory for a coherent spacetime substrate whose long-wavelength response reproduces Newtonian gravity. The substrate is represented at macroscopic scales by a scalar density field coupled universally to standard matter through an effective metric whose leading conformal sector generates the Newtonian limit and whose disformal sector defines higher-gradient viability constraints, . The microscopic equation of state of the substrate is taken from companion work and is not derived here. We obtain the linearized field equation for the density perturbation around a homogeneous background, identify a Poisson-like source law , and show that the gradient of the substrate density acts on matter through an effective force . The Newtonian limit is recovered exactly when the two response coefficients satisfy the calibration condition . A benchmark thermodynamic closure for maps these coefficients to substrate parameters, reducing the calibration to a constraint on one microscopic combination rather than an arbitrary split of . The tensorial Einstein–Hilbert sector is not derived, but imposed as an infrared matching condition required for relativistic consistency. We formulate the matching prescription that prevents double counting: the densification potential and the infrared Newtonian potential are identified as the same object, not additive. Disformal and higher-derivative corrections, together with post-Newtonian and multi-messenger constraints, are characterized as viability conditions on the effective parameter space rather than as derived predictions. No claims are made in this paper concerning post-Newtonian observables, gravitational waves, galactic phenomenology, or strong-field dynamics; these are deferred to companion work. Keywords: emergent gravity; effective field theory; disformal coupling; Newtonian limit; induced gravity; infrared matching; scalar–tensor theories.Paulo G.A. Suassuna

2026-05-26https://doi.org/10.5281/zenodo.20328311Zenodo (CERN European Organization for Nuclear Research) 202613D polyurethane vaginal rings for the delivery of steroid hormones using material extrusion additive manufacturingThree-dimensional printing has emerged as a novel technology to produce vaginal rings (VRs). However, the inherent high flexibility demanded by VRs poses a challenge when using filaments during the printing process. Here, we introduce a new approach for continuous 3D printing that eradicates the dependence on filaments and their printability for the fabrication of highly flexible VRs. Herein, Hot Melt Extrusion (HME) was used to create progesterone (PGR)-loaded thermoplastic polyurethane (TPU) pellets that were used as feedstock for 3D printing material extrusion of VRs. The TPU-based VRs presented excellent printability performance. Further physicochemical characterization indicated the presence of high amorphous PGR content while mechanical tests revealed that the VRs were consistently manufactured without significant deformation under prolonged compression and their performance was comparable to that of commercial VRs. The printed rings presented sustained release of clinically relevant quantities of progesterone over 28 days. Ex vivo studies showed that PGR permeated the porcine mucosa in a sustained manner for at least seven days. Finally, no cytotoxicity was observed in murine fibroblasts for the plain and progesterone-loaded pellets. This study demonstrates the potential of coupling HME and direct extrusion to produce 3D-printed VRs, aligning with the characteristics of traditional devices.Laura Andrade Junqueira; Atabak Ghanizadeh Tabriz; Savvas Koltsakidis; Dimitrios Tzetzis; Francisco José Raposo; Dennis Douroumis; Marcos Antônio Fernandes Brandão; Nádia Rezende Barbosa Raposo

Steroid; Extrusion; Polyurethane; Hormone; Steroid hormone; Pharmaceutical technology; Chemistry; Polymer chemistry; Chromatography; Chemical engineering

2026-05-22https://doi.org/10.1016/j.ijpharm.2026.127004International Journal of Pharmaceutics 20261Tuberculosis in Pregnancy: An Updated Narrative ReviewTuberculosis remains one of the leading infectious causes of morbidity and mortality worldwide, disproportionately affecting women of reproductive age, particularly in low- and middle-income countries. Tuberculosis during pregnancy represents a major clinical challenge, as physiological and immunological changes associated with pregnancy may obscure symptoms, delay diagnosis, and contribute to adverse maternal and perinatal outcomes. This narrative review provides an updated and clinically oriented overview of tuberculosis during pregnancy, with particular emphasis on diagnostic challenges, imaging strategies, microbiological testing, maternal-fetal complications, and therapeutic management. Key topics include symptom-based screening, tuberculin skin test and interferon gamma release assays, as well as molecular diagnostic methods such as GeneXpert Mycobacterium tuberculosis/Rifampicin (MTB/RIF) and Xpert MTB/RIF Ultra, chest radiography, computed tomography, and emerging biomarkers. We also discuss the impact of tuberculosis on pregnancy outcomes, including prematurity, low birth weight, maternal morbidity, and neonatal complications, as well as the particular challenges posed by human immunodeficiency virus HIV coinfection and multidrug-resistant tuberculosis. Current treatment strategies, preventive approaches, postpartum care, neonatal management, and Bacille Calmette-Guérin vaccination are reviewed in light of contemporary evidence and international recommendations. Finally, we highlight practical diagnostic algorithms, current evidence gaps, and priorities for future research aimed at improving maternal and neonatal outcomes in both high- and low-resource settings.Carolina Longo; Karina Felippe Monezi Pontes; Marina Matos de Moura Faíco; Mayra Martins Melo; Gustavo Yano Callado; Celio de Barros Barbosa; Edward Araujo Júnior; António Braga

Tuberculosis; Narrative review; Pregnancy; Mycobacterium tuberculosis; Coinfection; Vaccination; Miscarriage; Tuberculosis diagnosis; GeneXpert MTB/RIF; Medicine; Intensive care medicine; Immunology; Pediatrics; Breastfeeding; Tuberculin; Review article; Obstetrics

2026-05-22https://doi.org/10.3390/diagnostics16111576Diagnostics 20261Barriers to kidney transplant referral in the state of Minas Gerais: nephrologists’ perspectivesBACKGROUND: In Brazil, there is a low percentage of patients on the waiting list for kidney transplantation (KT), even within a public health system with full coverage. Among the factors influencing referral, those related to the nephrologist are the least studied. We aimed to investigate the barriers to KT referral from the perspective of nephrologists in the state of Minas Gerais. METHODS: Cross-sectional study of a convenience sample of active nephrologists. We collected data through an electronic survey, including demographic profile, education, professional profile, knowledge about indications (6) and contraindications (12), and clinical practice. Non-parametric analyses were performed. RESULTS: The 77 nephrologists had a median age of 44.9 years (IQR 39-52) and a median of 12.5 years (IQR 3-23) of clinical practice; all had completed postgraduate training. The median number of expected responses regarding contraindications was 8 (IQR 6-9) out of 12, and 66.2% had more than 50% of correct responses. There were no significant associations with this pattern of responses (< 8). The nephrologists reported knowing the referral process and identified the presence of contraindications as the main cause for non-referral. Centers were public (54.5%) and non-academic (55.8%); 69.2% were located within < 100 km of a KT center, most offered KT as a treatment modality (80.4%), only 14.7% reported difficulties with pre-KT laboratory tests, and 21-40% of patients were reported to be listed (31.2%). CONCLUSION: We found knowledge gaps in KT contraindications and risk perception as causes for non-referral. Barriers related to centers and the health system were not reported. These findings support educational initiatives and greater integration between nephrology services and KT centers to enable referrals.Cristianne de Medeiros Nogueira; Luiza Cunha MARTINS; Helady Sanders‐Pinheiro

Referral; Public health; Nephrology; Kidney transplantation; Transplantation; Patient referral; Medicine; Family medicine; Kidney disease; Emergency medicine; Kidney transplant; Intensive care medicine

2026-01-01https://doi.org/10.1590/2175-8239-jbn-2025-0215enBrazilian Journal of Nephrology 20261Preceptor activities and preparation time in medical residency: a hospital-based surveyABSTRACT Introduction: Preceptorship is a central element of medical residency, but there are gaps in formal assignments and the time required to prepare and execute teaching activities. Objective: To identify mandatory and optional preceptorship activities and estimate the time dedicated to their preparation and execution in a teaching hospital. Methods: This was an observational, cross-sectional study via an online survey of preceptors from COREME-accredited programs. The 44-item questionnaire covered profile, practice locations, and teaching/evaluation activities, as well as preparation/execution time. The analyses were descriptive. Results: 68/322 preceptors (21.1%) from multiple specialties responded. The most frequent teaching activities were participation in clinical meetings, outpatient case discussions, and non-surgical skills teaching. Among the mandatory activities, outpatient case discussions, participation in clinical meetings, and non-surgical skills teaching prevailed. Class preparation required 2 to 6 hours; the preparation of clinical case discussions, on average 4 hours; and the development/administration of assessments, approximately 3 hours per month. Conclusion: The scope of preceptorship at the institution is varied and aligned with competency-based curricula; clinical case discussions, when mandatory, required the most preparation and implementation time. The findings provide a basis for determining the workload and organization of preceptorship activities in medical residency programs.Jair Moreira Dias; Maria Fernanda Noel Dias; Gerson Alves Pereira Júnior; Sandra Helena Cerrato Tibiriçá; Márcio Schiefer; Adriano Fernando [UNIFESP] Mendes Junior

Preceptor; Workload; Class (philosophy); Time management; Scope (computer science); Clinical Practice; Medical education; Medicine; Nursing; Psychology

2026-01-01https://doi.org/10.1590/1981-5271v50.supl.1-20260007.ingRevista Brasileira de Educação Médica 20261Atividades do preceptor e tempo de preparo na residência médica: surveyRESUMO Introdução: A preceptoria é elemento central da residência médica, porém há lacunas sobre as atribuições formais e o tempo necessário para preparo e execução das atividades docentes. Objetivo: Este estudo teve como objetivos identificar atividades regulamentares e opcionais da preceptoria e estimar o tempo dedicado ao seu preparo e à execução em um hospital de ensino. Método: Trata-se de um estudo observacional, transversal, via survey on-line realizado com preceptores de programas credenciados pela Coreme. O questionário (44 itens) abrangeu perfil, locais de atuação e atividades de ensino/avaliação, além de tempo de preparo/execução. As análises foram descritivas. Resultado: Responderam 68/322 preceptores (21,1%) de múltiplas especialidades. As atividades de ensino mais frequentes foram participação em reunião clínica, discussão de casos em ambulatório e ensino de habilidades não cirúrgicas. Entre as consideradas regulamentares, prevaleceram discussão de casos em ambulatório, participação em reunião clínica e ensino de habilidades não cirúrgicas. O preparo de aulas demandou de duas a seis horas; a preparação de discussões de casos clínicos, em média quatro horas; e a elaboração/aplicação de avaliações, cerca de três horas por mês. Conclusão: O escopo da preceptoria na instituição é variado e alinhado a currículos por competência; a discussão de casos clínicos, quando regulamentar, concentrou maior tempo de preparo e execução. Os achados fornecem substrato para o dimensionamento de carga e a organização das atividades de preceptoria na residência médica.Jair Moreira Dias; Maria Fernanda Noel Dias; Gerson Alves Pereira Júnior; Sandra Helena Cerrato Tibiriçá; Márcio Schiefer; Adriano Fernando [UNIFESP] Mendes Junior

Preceptor; Immunoscintigraphy; Ultrasonography; Medicine; Physics; Humanities; Philosophy; Gynecology

2026-01-01https://doi.org/10.1590/1981-5271v50.supl.1-20260007Revista Brasileira de Educação Médica 20261Avaliação da Sobrecarga Laboral de Cuidadores de Pacientes Sob Cuidados PaliativosIntrodução: O envelhecimento populacional e o avanço das doenças crônico-degenerativas impõem desafios aos sistemas de saúde, sobretudo na oferta de cuidados paliativos (C.P). Nesse contexto, os cuidadores desempenham papel fundamental, frequentemente sem preparo técnico ou suporte institucional adequados, o que resulta em sobrecarga emocional e física. Objetivos: Avaliar os fatores que contribuem para a sobrecarga dos cuidadores na região metropolitana de Belo Horizonte, MG, e como isso afeta a qualidade de vida deles e o cuidado prestado aos pacientes. Métodos: Trata-se de uma pesquisa qualitativa, descritiva e exploratória, realizada por meio de entrevistas com sete cuidadores formais e informais. Utilizou-se a técnica de amostragem “bola de neve” para compreender a experiência vivida pelos participantes. Resultados: Resultados revelaram três categorias temáticas: a sobrecarga emocional e física do trabalho; ausência de suporte institucional e invisibilidade do cuidador e; as estratégias pessoais de enfrentamento e fortalecimento emocional. Conclusão: Os relatos dos participantes evidenciam a presença consistente de sinais de sobrecarga física e emocional, mesmo diante das estratégias individuais mobilizadas para enfrentar as demandas do cuidado. Os achados reforçam a urgência de ampliação das investigações sobre a temática, bem como da formulação e implementação de políticas públicas que reconheçam a centralidade do cuidador no processo assistencial, assegurando-lhe suporte institucional, acolhimento qualificado e condições adequadas para o exercício do cuidado.Júlio Cesar Batista Santana Santana; Mariane da Costa Moura MOURA; Fernanda Cristina de Andrade Reis; Gabriella Silva Lazaroti; Letícia Rodrigues Jacomino; Anna Carolina de Freitas Policarpo; Taynná El Cury Silva; André Lucas Caldeira Brant de OIiveira

Palliative care; Quality of life (healthcare); Nursing care; Family caregivers; Medicine; Nursing; Psychology; Sociology

2026-05-22https://doi.org/10.36489/saudecoletiva.2026v17i108p20144-20161Saúde Coletiva (Barueri) 20261A Revived Calling: The Chaplains of the Brazilian Expeditionary Force during the Second World WarDuring World War II, the Brazilian Expeditionary Force (BrazEF) reinstated religious assistance after decades of military secularization. This article examines the role of these chaplains in providing emotional and spiritual support to soldiers on the Italian front. Drawing on archival records, chaplain reports and personal testimonies, it explores how faith influenced troop morale and psychological resilience. While inspired by global chaplaincy models, Brazil’s case was distinctive: religion, long absent from military life, became central once again. Despite their rushed training and the logistical challenges they experienced, chaplains became indispensable figures. Their experiences not only reshaped the BrazEF’s wartime dynamics, but also influenced the permanent re-establishment of military religious assistance in 1946.Ana Amélia G. Dias

Faith; World War II; First world war; Christian faith; Military personnel; Political science; Law; History; Management

2026-05-22https://doi.org/10.1017/stc.2026.10057Studies in Church History 20261Einstein–Aether primordial universe with radiation and dark energyAbstract We investigate a quantum cosmological model within the framework of Einstein–Aether gravity. The model consists of a positively curved FLRW Universe whose matter content is described by a radiation fluid, in the presence of a positive cosmological constant $$\Lambda $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mi>Λ</mml:mi> </mml:math> . We first perform a classical Hamiltonian analysis, constructing the phase space and deriving the dynamics of the scale factor. Notably, we identify specific initial conditions that lead to an inflationary expansion. Subsequently, we quantize the model following Dirac’s formalism, obtaining the Wheeler-DeWitt equation for the wave function of the Universe. We solve this equation numerically and compare our results to those of the WKB approximation, computing quantum tunneling probabilities and the expectation value of the scale factor, along with its standard deviation. Finally, we analyze how these tunneling probabilities are influenced by variations in the fundamental parameters of the theory ( $$\Lambda $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mi>Λ</mml:mi> </mml:math> , $$\sigma $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mi>σ</mml:mi> </mml:math> , $$\beta $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mi>β</mml:mi> </mml:math> ) and the energy of the fluid E . Our results indicate a higher probability for the quantum birth of the Universe in a parameter regime characterized by larger values of $$\Lambda $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mi>Λ</mml:mi> </mml:math> , $$\sigma $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mi>σ</mml:mi> </mml:math> , and fluid energy E , together with a smaller value of $$\beta $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mi>β</mml:mi> </mml:math> .A. Oliveira Castro Junior; G. A. Monerat; G. Oliveira-Neto; E V Corrêa Silva

WKB approximation; Friedmann–Lemaître–Robertson–Walker metric; Dark energy; De Sitter universe; Cosmological constant; Vacuum energy; Universe; Quantum cosmology; Phase space; Quantum; Physics; Quantum mechanics; Cosmological perturbation theory; Hamiltonian (control theory); Dark matter; Background radiation; Metric expansion of space; Cosmology; Primordial fluctuations; Lambda-CDM model; Theoretical physics; Quantum fluctuation; Quantum tunnelling; Equation of state

2026-05-22https://doi.org/10.1140/epjc/s10052-026-15788-9The European Physical Journal C 20261Effectiveness and feasibility of home-based physical exercise interventions for children and adolescents with chronic diseases: a systematic review and meta-analysisOBJECTIVE: (1) To synthesise the available evidence on the clinical effectiveness of home-based physical exercise interventions in improving aerobic capacity, functional capacity, muscle strength and quality of life in children and adolescents with chronic diseases, as well as to evaluate their feasibility; and (2) to assess the reporting quality of these interventions using the Consensus on Exercise Reporting Template, with the aim of identifying gaps in methodological transparency that may limit reproducibility and scalability. DESIGN: Systematic review and meta-analysis. DATA SOURCES: Medline (via PubMed), Web of Science, Cochrane Central Register of Controlled Trials (CENTRAL), SportDiscus and CINAHL database (via EBSCOhost) were searched until 31 December 2025. ELIGIBILITY CRITERIA: Eligible studies included intervention designs (randomised controlled trials (RCTs), non-randomised trials and before-after studies) that evaluated home-based physical exercise interventions in children and adolescents with chronic diseases. Studies were required to include a comparator (eg, centre-based interventions, alternative home-based interventions, such as motor imagery, constraint-induced movement therapy or hand-arm bimanual intensive therapy or no intervention) or to report within-group (baseline-to-follow-up) comparisons. Outcomes of interest were aerobic capacity, functional capacity, muscle strength and quality of life. RESULTS: A total of 81 studies were included, comprising 2923 children and adolescents. The most frequently represented conditions were cerebral palsy (n=26; 32.1%), cystic fibrosis (n=10; 12.3%) and idiopathic arthritis (n=8; 9.8%). Of the 45 RCTs identified, 19 met the criteria for inclusion in the meta-analysis. Home-based physical exercise interventions were effective in increasing aerobic capacity (p<0.0001; standardised mean differences: 0.53; 95% CI 0.32 to 0.74) compared with the control group. No significant differences were observed between home-based interventions and control conditions for functional capacity or quality of life. However, functional capacity gains are similar when comparing centre-based and home-based approaches. A meta-analysis of muscle strength could not be performed due to insufficient data. Adherence to home-based physical exercise interventions was higher than 80% in 27 of the 50 studies that reported this information. Most studies reported no adverse events of home-based physical exercise interventions, with few studies reporting only mild adverse effects (eg, muscle soreness, stiffness and fatigue). CONCLUSIONS: Our meta-analysis of randomised controlled trials comparing home-based interventions with control conditions suggests that home-based physical exercise is feasible and improves aerobic capacity, but does not confer significant benefits for functional capacity, muscle strength or quality of life in children and adolescents with chronic diseases. Suboptimal reporting quality, risk of bias and inconsistent adherence/safety data necessitate cautious interpretation. PROSPERO REGISTRATION NUMBER: CRD42022330567.Sofia Mendes Sieczkowska; Danilo Reis Coimbra; Fabiana Infante Smaira; Bruna Caruso Mazzolani; Gabriela Paticcié; Camila Astley; Amanda Iraha; Hamilton Roschel; Tiago Peçanha; Bruno Gualano

CINAHL; Psychological intervention; Cerebral palsy; Aerobic exercise; MEDLINE; Quality of life (healthcare); Randomized controlled trial; Systematic review; Clinical trial; Medicine; Physical therapy; Physical medicine and rehabilitation; Minimal clinically important difference; Meta-analysis; Data extraction; Rehabilitation; Evidence-based medicine; Physical fitness; Intervention (counseling)

2026-05-22https://doi.org/10.1136/bjsports-2025-110204British Journal of Sports Medicine 20261A fully coupled thermo-damage model for concrete cracking with two-way field interactionsLahis Assis; Michele Farage; Flávia de Souza Bastos

Cracking; Multiphysics; Thermal; Field (mathematics); Reduction (mathematics); Work (physics); Process (computing); Finite element method; Materials science; Structural engineering; Heat transfer; Material properties; Ultimate tensile strength; Composite material; Micromechanics; Thermal resistance

2026-01-01https://doi.org/10.2139/ssrn.6814979SSRN Electronic Journal 20261Analytical approaches applied to antimalarial drugs analysis: a critical reviewPatrícia Abranches Geraldo; Jéssica Cordeiro Queiroz de Souza; Raphaela Cristina Cancela Marques; Larissa dos Anjos Castro; Luiz Henrique Cantarino Adriano; Pedro Pereira Rezende de Moura; Paula Rocha Chellini; Marcone Augusto Leal de Oliveira

Drug; Antimalarial Agent; Intensive care medicine; Pharmacology; Biochemical engineering; Medicine; Chemistry; Risk analysis (engineering); Computer science

2026-05-24https://doi.org/10.1016/j.microc.2026.118481Microchemical Journal 20261analise_estatistica.RScript de código em linguagem R contendo os pacotes de estimação de modelos de Mínimos Quadrados Ordinários em Dois Estágios (MQO2E) via pacote 'fixest', rotinas de testes de primeiro estágio, matrizes de correlação e os testes de falsificação/placebo.Luiz Pedro Silva; Suzana Bastos Quinet

Term (time); Presentation (obstetrics); Identity (music); Computer science

2026-01-01https://doi.org/10.48331/scielodata.kcamuk/3abql5SciELO - Scientific Electronic Library Online Dataverse 20261Readme.txtLuiz Pedro Silva; Suzana Bastos Quinet

2026-01-01https://doi.org/10.48331/scielodata.kcamuk/fslqmgSciELO - Scientific Electronic Library Online Dataverse

20261Day-ahead Electricity Demand Forecasting in an Electrified Seaport using Crane SchedulingAbstract In the coming years, seaports will undergo significant electrification process, moving away from fossil fuels. In such new reality, obtaining accurate electricity load forecasting is critical for reducing costs, planning infrastructure improvements, and ensuring a stable energy supply. However, studies specifically addressing this need in ports are scarce. This paper presents several novel Long Short-Term memory (LSTM) models for forecasting the electricity demand of a highly electrified port, using the Port of Sines as a case study. These models incorporate operational data, such as vessel arrival schedules and quay crane usage, to enhance forecasting accuracy. Our results show that including these variables significantly improves forecast accuracy, reducing the Mean Absolute Percentage Error (MAPE) from 10.55% to 3.59% compared to models relying solely on historical data. This research provides a robust framework for ports to improve energy management and supports the broader goals of energy efficiency and sustainability in the maritime industry.Felipe Do Carmo; Adrian Carrillo-Galvez; Tiago Soares; Bruno H. Dias; Bernardo Silva

Electrification; Electricity; Scheduling (production processes); Demand forecasting; Port (circuit theory); Sustainability; Electricity demand; Operations research; Computer science; Energy demand; Efficient energy use

2026-05-23https://doi.org/10.1007/s40866-026-00350-zSmart Grids and Sustainable Energy 20261Himatanthus drasticus (Mart.) Plumel (APOCYNACEAE): phytochemical profile, evaluation of antibacterial and drug-potentiating activity, and toxicity of stem bark extractsMaraiza Gregório de Oliveira; Adrielle Rodrigues Costa; Jailson Renato de Lima Silva; Carlos Alonso Leite dos Santos; Ana Raquel Pereira da Silva; Daniel Sampaio Alves; José Weverton Almeida-Bezerra; Ademar Maia Filho; José Walber Gonçalves Castro; Bárbara Fernandes Melo; Francisca de Fátima Silva de Sousa; Marcos Antônio Martins Dos Santos; Lariza Leisla Leandro Nascimento; Maria Audilene de Freitas; Nara Juliana Santos Araújo; Severino Denício Gonçalves de Sousa; Luiz Filipi Teles Feitosa; Janaína Esmeraldo Rocha; Henrique Douglas Melo Coutinho; Antônia Eliene Duarte; Luiz Marivando Barros

Phytochemical; Toxicity; Antibacterial activity; Bark (sound); Antibiotics; Antimicrobial; Traditional medicine; Biology; Medicine

2026-05-23https://doi.org/10.1007/s42535-026-01736-1Vegetos 20261painel_final.tabBase de dados final consolidada e estruturada em painel balanceado. Gerada originalmente em formato nativo do Stata (.dta), contendo todas as variáveis tratadas, controles, desfechos e instrumentos prontos para replicação.Luiz Pedro Silva; Suzana Bastos Quinet

Base (topology); Work (physics); Term (time); Component (thermodynamics)

2026-01-01https://doi.org/10.48331/scielodata.kcamuk/3ttiuxSciELO - Scientific Electronic Library Online Dataverse 20261painel_final-1.tabVersão em formato de planilha Excel do painel de dados final utilizado no estudo.Luiz Pedro Silva; Suzana Bastos Quinet

2026-01-01https://doi.org/10.48331/scielodata.kcamuk/psr3u9SciELO - Scientific Electronic Library Online Dataverse

20261BaseMCMVmindascidades.xlsxLuiz Pedro Silva; Suzana Bastos Quinet

2026-01-01https://doi.org/10.48331/scielodata.kcamuk/qrx7rkSciELO - Scientific Electronic Library Online Dataverse

20261Pigmentos vermelhos em pinturas rupestres de Inhuma (Piauí, Brasil): uma abordagem arqueométrica integrada por P-EDXRF e RamanEste estudo investiga a composição químico-mineralógica de pigmentos vermelhos de pinturas rupestres do Complexo da Ema, no município de Inhuma, Piauí, Brasil. Foram empregadas técnicas não destrutivas, como fluorescência de raios X portátil (P-EDXRF) e espectroscopia Raman, associadas a exame microscópico e tratamento digital de imagens. Os resultados indicam a hematita (α-Fe2O3) como principal cromóforo, com variações de tonalidade relacionadas à espessura da camada pictórica, minerais associados e processos pós-deposicionais. Essa pesquisa traz contribuições iniciais para a compreensão material das pinturas, com implicações para sua conservação.Tetisuelma Leal Alves; Benedito Batista Farias Filho; Wilkins Oliveira de Barros; Luiz Fernando Cappa de Oliveira; Julliana da Fonseca Alves; Anna Luiza B. Brito

Vermilion; Raman spectroscopy; Solid-state; Pigment; Chemistry

2026-05-06https://purl.org/aia/5712Zenodo (CERN European Organization for Nuclear Research) 20261base.RScript de código em linguagem R destinado à raspagem de dados políticos de prefeitos eleitos via API do TSE (pacote 'electionsBR'), padronização geográfica dos municípios pertencentes às Regiões Metropolitanas e cálculo das interações anuais do instrumento Shift-Share (Bartik).Luiz Pedro Silva; Suzana Bastos Quinet

Context (archaeology); Key (lock); Product (mathematics); Term (time); Mathematics

2026-01-01https://doi.org/10.48331/scielodata.kcamuk/vzajllSciELO - Scientific Electronic Library Online Dataverse 20261PainelDeficitHabit.tabDados secundários consolidados contendo as estimativas brutas e intermediárias de déficits habitacionais e inadequações de domicílios extraídos da Fundação João Pinheiro (FJP).Luiz Pedro Silva; Suzana Bastos Quinet

Context (archaeology); Work (physics); Data set; Data collection; Computer science

2026-01-01https://doi.org/10.48331/scielodata.kcamuk/zqkvinSciELO - Scientific Electronic Library Online Dataverse 20261Data for: Os impactos do programa Minha Casa Minha Vida em condições de moradia nas cidadesReplication data for the study analyzing the causal impacts of the Minha Casa Minha Vida (MCMV) housing program on urban housing deficits and quality of life across 36 major Brazilian urban areas between 2011 and 2015. To address endogeneity and simultaneity biases in program allocation, the research employs a Shift-Share (Bartik) Instrumental Variable strategy (2SLS/MQO2E), interacting nationwide federal funding shocks from the Fundo de Arrendamento Residencial (FAR) with local political alignment measures derived from municipal elections. Standard errors are adjusted using the Driscoll-Kraay method to ensure robustness against spatial dependency and serial autocorrelation. The dataset includes socio-demographic controls from PNAD (IBGE) microdata, municipal-level housing delivery records from the Ministry of Cities, and quantitative deficit estimations from the João Pinheiro Foundation (FJP). Complete Stata and R scripts are provided to ensure full scientific reproducibility.Luiz Pedro Silva; Suzana Bastos Quinet

Endogeneity; Christian ministry; Instrumental variable; Robustness (evolution); Dependency (UML); Flemish; Census; Data collection; Politics; Welfare economics; Political science; Geography; Quality (philosophy); Variable (mathematics); Estimation; Regional science; Data quality; Computer science

2026-05-22https://doi.org/10.48331/scielodata.kcamukSciELO - Scientific Electronic Library Online Dataverse 20261Entre as regras do jogo e o jogo das regras: a lógica empresarial na rede privada de ensinoEste artigo analisa as regras do jogo que organizam a atuação do professor de Música na Educação Infantil da rede privada de ensino, a partir do ponto de vista desses docentes. O objetivo é identificar e compreender como as regras se articulam em torno de uma lógica empresarial e quais são seus efeitos sobre a profissionalização do professor de Música. Ancorado na perspectiva bourdieusiana, especialmente nos conceitos de campo, senso prático e regras do jogo, busca-se desvelar princípios organizadores que operam de forma majoritariamente tácita na escola. Metodologicamente, a pesquisa baseia-se em entrevistas semiestruturadas com professores de Música atuantes em escolas privadas que oferecem as três etapas da Educação Básica, localizadas na cidade do Rio de Janeiro. A análise dos dados permitiu identificar regularidades relacionadas às exigências do trabalho docente, às regras comuns da rede privada e ao valor atribuído à Música e ao professor que a ensina. Os resultados indicam que essas regularidades não se apresentam de forma dispersa, mas se organizam em torno de uma lógica empresarial que redefine critérios de valoração, formas de regulação e expectativas institucionais. Embora a Música seja mobilizada como diferencial competitivo, os efeitos dessa lógica incidem negativamente sobre a autonomia pedagógica, o reconhecimento profissional e as condições de exercício da docência, configurando processos de desprofissionalização de natureza simbólica e organizacional. O artigo propõe, por fim, Quadros de Regras como instrumentos analíticos para leitura crítica do campo, sem caráter prescritivo.Maria Angélica de Toledo Calderano da Costa; Marcus Vinicius Medeiros Pereira

Context (archaeology); Constitution; Autonomy; Order (exchange); Subject (documents); Work (physics); Control (management); Perspective (graphical); Humanities; Political science; Sociology; Field (mathematics)

2026-05-23https://doi.org/10.33054/abem202634107Revista da ABEM 20261Pigmentos vermelhos em pinturas rupestres de Inhuma (Piauí, Brasil): uma abordagem arqueométrica integrada por P-EDXRF e RamanEste estudo investiga a composição químico-mineralógica de pigmentos vermelhos de pinturas rupestres do Complexo da Ema, no município de Inhuma, Piauí, Brasil. Foram empregadas técnicas não destrutivas, como fluorescência de raios X portátil (P-EDXRF) e espectroscopia Raman, associadas a exame microscópico e tratamento digital de imagens. Os resultados indicam a hematita (α-Fe2O3) como principal cromóforo, com variações de tonalidade relacionadas à espessura da camada pictórica, minerais associados e processos pós-deposicionais. Essa pesquisa traz contribuições iniciais para a compreensão material das pinturas, com implicações para sua conservação.Tetisuelma Leal Alves; Benedito Batista Farias Filho; Wilkins Oliveira de Barros; Luiz Fernando Cappa de Oliveira; Julliana da Fonseca Alves; Anna Luiza B. Brito

Vermilion; Raman spectroscopy; Solid-state; Pigment; Chemistry

2026-05-06https://doi.org/10.5281/zenodo.20355549Zenodo (CERN European Organization for Nuclear Research) 20261montagempainel.doScript de código/rotina em linguagem Stata (.do) utilizado para a abertura dos microdados originais da Pnad Anual (IBGE), filtros amostrais, extração e cálculo das variáveis socioeconômicas/demográficas de controle e consolidação inicial da estrutura de painel por região urbana.Luiz Pedro Silva; Suzana Bastos Quinet

Statistical analysis; Filter (signal processing); Noise (video); Mathematics

2026-01-01https://doi.org/10.48331/scielodata.kcamuk/orrt6aSciELO - Scientific Electronic Library Online Dataverse 20261Heteroleptic palladium(II) complexes bearing ethylenediamine and their activity against resistant Campylobacter jejuniMeiry Leandra de Lacerda; Letícia Roberta Martins Costa; Clara Maria Faria Silva; Daise Aparecida Rossi; Robson José de Oliveira Júnior; Roberta Torres de Melo; Hélio Ferreira Dos Santos; Wendell Guerra

Ethylenediamine; Bearing (navigation); Campylobacter jejuni; Bacteria; Chemistry; Stereochemistry

2026-05-24https://doi.org/10.1016/j.molstruc.2026.146658Journal of Molecular Structure 20261Laser de baixa intensidade no manejo do herpes-zoster oftálmico: um relato de casoIntrodução: O vírus varicela-zoster (VZV), agente etiológico da varicela, pode reativar-se e causar herpes-zoster (HZ) oftálmico, especialmente em situações de imunossupressão ou estresse. Objetivo: Relatar a evolução clínica de uma paciente jovem com herpes-zóster oftálmico, destacando o possível papel de laser de baixa intensidade (LLLT) como terapia adjuvante na melhora dos sintomas e na cicatrização das lesões. Relato de Caso: Relata-se o caso de uma paciente de 27 anos que apresentou dor, sensação de queimação e lesões vesiculares na região palpebral direita, evoluindo para diagnóstico de HZ oftálmico. O manejo incluiu antivirais sistêmicos, corticosteroides, analgésicos, suplementação vitamínica e aplicações de (LLLT) como terapia adjuvante. Durante o acompanhamento clínico, observou-se redução progressiva da dor, formação de crostas nas lesões e evolução favorável do quadro. Conclusão: Embora ainda não exista protocolo padronizado para o uso do LTTT no tratamento do HZ oftálmico, a evolução clínica observada neste caso sugere que seu emprego como terapia adjuvante, associado ao tratamento sistêmico, pode ter contribuído para o manejo sintomático e para a recuperação das lesões.Amanda Marota de Oliveira; Rodrigo Simões de Oliveira; Vitória Batista Clemente; Matheus Fernandes Lasneau Moraes; Mariana Simões de Oliveira; Ana Carolina Morais Apolônio

Laser therapy; Laser; Head and neck; Laser treatment; Medicine; Gynecology; Surgery

2026-05-01https://doaj.org/article/309eab8a0a4147bf8b773aad935a49dbDOAJ (DOAJ: Directory of Open Access Journals) 20261Inteligência Artificial na pré-aula e Sala de Aula Invertida na formação continuada de professores de Matemática: um Mapeamento Sistemático da LiteraturaThis paper presents a restructured Systematic Literature Mapping (SLM) on the use of the flipped classroom in continuing professional development for mathematics teachers, supported by Generative Artificial Intelligence (AI) in pre-class activities. The aim was to organize the protocol, search process, selection criteria, data extraction procedures and corpus analysis according to the expected stages of an SLM. Searches were consolidated across three sources - CAPES Journal Portal, Google Scholar and Scopus - and resulted in 28 studies: 15 from CAPES, seven from Google Scholar and six from Scopus. Findings show a marked increase in publications between 2023 and 2025, a predominance of theoretical/documentary studies and a concentration of Brazilian publications. Of the 28 studies, 22 focus on Mathematics Education, nine address teaching or teacher education, five provide indirect evidence on pre-class planning with AI, and only one explicitly presents a flipped classroom architecture. No study was found that simultaneously combines continuing mathematics teacher education, flipped classroom and AI-supported pre-class activities. The mapping indicates a consistent partial foundation for the research question, while also showing that the exact intersection remains open and requires Design Science Research oriented intervention studies.GREGSON BARROS DA SILVA; José Maria Nazar David

Flipped learning; Flipped classroom; Scopus; Selection (genetic algorithm); Intersection (aeronautics); Panning (audio); Intervention (counseling); Mathematics education; Continuing education; Pedagogy; Humanities

2026-05-23https://doi.org/10.5281/zenodo.20360593Zenodo (CERN European Organization for Nuclear Research) 20261Inteligência Artificial na pré-aula e Sala de Aula Invertida na formação continuada de professores de Matemática: Resultados e analises iniciais de um Mapeamento Sistemático da LiteraturaEste documento apresenta os resultados iniciais de um protocolo de Mapeamento Sistemático de Literatura realizado no entre fevereiro e março de 2026, considerando análise dos corpus identificados afins a essa pesquisa. A proposta foi identificar o estado da arte do uso das Inteligências Artificiais Generativas como suporte no processo de formação continuada do professor de Matemática, atuando como auxiliar para o contexto formativo assim como no planejamento de aulas que no caso deste levantamento com suporte da metodologia de ensino alternativa da Sala de Aula Invertida.GREGSON BARROS DA SILVA; José Maria Nazar David

Context (archaeology); Continuing education; Process (computing); Taste; Humanities; Art

2026-05-23https://doi.org/10.5281/zenodo.20360701Zenodo (CERN European Organization for Nuclear Research) 20261COMPARAÇÃO DOS FATORES MOTIVACIONAIS ASSOCIADOS À PRÁTICA DO VOLEIBOL ENTRE ATLETAS DE CLUBES E ESCOLARESO esporte é reconhecido como um importante fenômeno sociocultural, especialmente entre crianças e adolescentes, sendo o voleibol uma das modalidades mais populares nesse contexto. A motivação desempenha papel central na prática esportiva, podendo ser influenciada por fatores intrínsecos, como prazer e bem-estar, e extrínsecos, como aspectos sociais. Nesse sentido, o estudo teve como objetivo comparar os fatores motivacionais associados à prática do voleibol entre atletas de clubes e escolares. Trata-se de um estudo quantitativo de corte transversal, realizado com 58 participantes, com idades entre 12 e 19 anos. Foi utilizada a Escala de Motivação à Prática de Atividades Físicas (MPAM-R), composta por cinco dimensões: Diversão/Interesse, Saúde/Fitness, Competência, Aparência e Social. Os dados foram analisados por meio de estatística descritiva e inferencial e foi adotado nível de significância de p<0,05. Os achados indicaram que os fatores motivacionais são, de modo geral, semelhantes entre atletas de clubes e escolares, com exceção da dimensão Social, que foi mais valorizada por atletas de clubes. A dimensão Saúde/Fitness apresentou-se como o principal motivo para a prática em ambos os grupos, seguida pela dimensão Diversão/Interesse. Por outro lado, a dimensão Aparência foi a menos relevante. Conclui-se que tanto aspectos relacionados à saúde quanto ao prazer e às interações sociais são determinantes importantes para a prática do voleibol por atletas de clubes e escolares.Nathália Barros da Silva; Aline Toledo de Oliveira; Josiane Aparecida de Almeida; Camille Dos Reis Molina; Leonardo Hadade Galdino; Eriberto José Lessa de Moura; Davi Correia da Silva

Athletes; Statistical analysis; Preference; Humanities

2026-05-24https://doi.org/10.70773/revistatopicos/779601849Revista Tópicos. 20261Inteligência Artificial na pré-aula e Sala de Aula Invertida na formação continuada de professores de Matemática: Resultados e analises iniciais de um Mapeamento Sistemático da LiteraturaEste documento apresenta os resultados iniciais de um protocolo de Mapeamento Sistemático de Literatura realizado no entre fevereiro e março de 2026, considerando análise dos corpus identificados afins a essa pesquisa. A proposta foi identificar o estado da arte do uso das Inteligências Artificiais Generativas como suporte no processo de formação continuada do professor de Matemática, atuando como auxiliar para o contexto formativo assim como no planejamento de aulas que no caso deste levantamento com suporte da metodologia de ensino alternativa da Sala de Aula Invertida.GREGSON BARROS DA SILVA; José Maria Nazar David

Context (archaeology); Continuing education; Process (computing); Taste; Humanities; Art

2026-05-23https://doi.org/10.5281/zenodo.20360592Zenodo (CERN European Organization for Nuclear Research) 20261Influence of Heat Treatment on the Shaping Ability of Rotary Instruments in Severely Curved Root Canals: A Stepwise AnalysisOBJECTIVE: This study aimed to assess the shaping ability of 2 preparation systems with similar designs but different heat treatments during the progressive enlargement of severely curved mesiobuccal and mesiolingual canals in mandibular molars. METHODS: Twenty-two mandibular molars with mesial canals curved >25º were scanned, pair-matched and divided into 2 groups (n=11) for preparation using austenitic (Genius) or martensitic (Genius Proflex) heat-treated instruments. Phase transformation temperatures of the instruments were determined via differential scanning calorimetry. Mesiobuccal and mesiolingual canals were first instrumented with a 17/.05 file and then sequentially enlarged using instruments sized 25/.04-40/.04, with scans taken after each enlargement step. Pre- and postoperative datasets were analysed for volume, surface area, unprepared canal areas, removed dentine volume, transportation and dentine thickness reduction. Statistical analyses included Student's t-test, Generalized Linear Model (GLM) multivariate model and independent t-tests (significance: P < .05). RESULTS: Genius displayed an austenitic structure, while Genius Proflex exhibited an R-phase structure at both 20ºC and 36ºC. Instrument size increase (P=.001) and heat treatment (P < .001) significantly affected shaping outcomes without interaction effects (P=.882). Size increases impacted canal volume (P=.023), unprepared areas (P=.005), removed dentine (P < .001) and dentine thickness reduction (P < .001), but not surface area (P=.390). Heat treatment significantly influenced unprepared canal areas (P < .001). Martensitic instruments caused less transportation (P < .05) and preserved more distal dentine (P < .001) compared to austenitic instruments. CONCLUSIONS: In severely curved mesial canals of mandibular molars, martensitic instruments result in fewer unprepared areas, reduced transportation and better dentine preservation at the distal root canal wall compared with austenitic instruments.Jeronimo Careaga; Ana Flávia Almeida Barbosa; Graziela dos Santos Massa; Carolina O. Lima; Erick Miranda Souza; R Domingos Da Costa Lopes; Jorge N.R. Martins; Francisco Manuel Braz-Fernandes; Marco A. Versiani; E V Corrêa Silva

Molar; Austenite; Martensite; Root canal; Reduction (mathematics); Linear relationship; Orthodontics; Materials science; Mathematics; Dentistry; Geology

2026-05-11https://doi.org/10.65717/eej.2026.25104European Endodontic Journal 20261Reliability and patient-centered feasibility of the Gross Motor Function Measure in children diagnosed with central nervous system tumorBACKGROUND AND OBJECTIVE: Children diagnosed with central nervous system (CNS) tumors frequently present with persistent motor impairments that compromise independence and participation. Although the Gross Motor Function Measure (GMFM-88) is widely used in pediatric neurology, evidence regarding its reliability and feasibility in pediatric neuro-oncology remains limited. Therefore, this study aimed to investigate the intra- and inter-rater reliability of the GMFM-88, its association with tumor volume, and evaluate the patient-centered clinical feasibility of the instrument. METHODS: This cross-sectional reliability study was conducted at a specialized cancer rehabilitation center. Participants were children with brain tumors confirmed by imaging and biopsy. Gross motor function was assessed using the GMFM-88 with all assessments video-recorded following a standardized protocol. Primary outcomes were intra- and inter-rater reliability. Intra-rater reliability was determined through the analysis of the video of the evaluation day, by the same rater after a four-week interval. Inter-rater reliability was assessed by a second, independent blinded rater who scored the same video recordings. Reliability was analyzed using intraclass correlation coefficients (ICC; two-way mixed-effects, absolute agreement). Secondary outcomes included the correlation between GMFM-88 total scores and tumor volume estimated via the ellipsoid method. To investigate the relationship between variables, Pearson's correlation coefficient was calculated. Furthermore, patient-centered clinical feasibility was assessed using a 7-point Likert scale addressing safety, administration speed, and acceptability. RESULTS: = .64). Feasibility ratings were high for safety (aggregate score 76/96) and acceptability (91/96), though administration speed was variable (64/96). DISCUSSION: The GMFM-88 is a highly reliable and clinically applicable tool for assessing gross motor function in pediatric neuro-oncology. The lack of correlation between tumor size and motor capacity suggests that functional outcomes may be more closely related to lesion topography in eloquent areas than volume alone. Major limitations include the single-center design and small sample size. However, these findings support its use as a standardized and clinically applicable outcome measure in pediatric neuro-oncological.Beatriz Mantovani; Paula S. C. Chagas; Everton Horiquini-Barbosa

Intraclass correlation; Reliability (semiconductor); Rehabilitation; Functional Independence Measure; Gross motor skill; Pearson product-moment correlation coefficient; Correlation; Medicine; Physical therapy; Physical medicine and rehabilitation; Intra-rater reliability; Test (biology); Motor function; Rating scale; Neurosurgery

2026-05-25https://doi.org/10.1080/17518423.2026.2679487Developmental Neurorehabilitation 20261O PAPEL ECONÔMICO DOS SETORES DE SAÚDE PÚBLICA E PRIVADA NO BRASILEsse artigo buscou analisar os impactos dos setores de saúde pública e saúde privada sobre a estrutura produtiva da economia brasileira, identificando seus encadeamentos intersetoriais e a intensidade de seus efeitos sobre os demais segmentos econômicos. Para isso, foi utilizado o modelo de insumo-produto baseado na matriz brasileira, aplicando-se a técnica de extração hipotética, que permite mensurar os impactos econômicos decorrentes da retirada simulada dos setores analisados. Os resultados demonstraram que ambos os segmentos exercem papel estratégico na economia nacional, embora apresentem padrões distintos de articulação produtiva. A saúde privada revelou impactos mais intensos e concentrados em setores industriais específicos, especialmente na indústria farmoquímica e farmacêutica, produtos químicos e fabricação de bens intermediários, indicando elevada densidade tecnológica e forte dependência de insumos especializados. Por outro lado, a saúde pública apresentou impactos mais distribuídos ao longo da economia, atingindo setores de infraestrutura, serviços administrativos e atividades de apoio institucional. Conclui-se que o setor de saúde ultrapassa sua função assistencial, constituindo-se como elemento estruturante do desenvolvimento econômico e industrial brasileiro, especialmente no âmbito do Complexo Econômico-Industrial da Saúde (CEIS).Itália Aparecida dos Santos Zanelli; Marcílio Zanelli Pereira

Context (archaeology); Private sector; Adaptability; Technological change; Political science; Business; Economics; Humanities

2026-05-25https://doi.org/10.51891/rease.v12i5.26788Revista Ibero-Americana de Humanidades, Ciências e Educação 20261THE IMPACT OF OBESITY ON THE CLINICAL COURSE OF INFLAMMATORY BOWEL DISEASEBACKGROUND: The incidence and prevalence of disorders such as obesity, metabolic syndrome (MS), and inflammatory bowel disease (IBD) have increased over recent decades. MS is a complex condition represented by a cluster of cardiovascular risk factors with a multifactorial origin-including genetic, behavioral, dietary factors, and alterations in gut microbiota. IBD reflects a complex and heterogeneous immune-mediated condition that typically, though not exclusively, affects the intestine. OBJECTIVE: To evaluate the impact of obesity on the clinical course of IBD in a cohort of patients followed at a referral center for IBD. METHODS: This was a retrospective longitudinal observational cohort study including patients of both sexes and all ethnicities, followed at the Inflammatory Bowel Disease Referral Center of the University Hospital of the Federal University of Juiz de Fora, between January 2019 and August 2023. A total of 404 adults aged 18 to 80 years with a diagnosis of IBD-established by clinical, endoscopic/histological, and/or imaging criteria-were included. IBD cases were classified as either Crohn's disease (CD) or ulcerative colitis (UC). To assess DII annual activity, electronic medical records were reviewed for outpatient visits and hospitalizations from 2019 to 2023. CD was considered active when the Harvey-Bradshaw Index (HBI) was ≥5, and UC was considered active when the total Mayo score was ≥3 or the partial Mayo score was ≥2. RESULTS: The mean age at IBD diagnosis was 37.79±13.44 years, with an average disease duration of 12.50±8.3 years. Biologic therapy was used in the majority of patients (58.4%), with treatment failure occurring in 56.8% of these cases during the study period. No statistically significant differences were observed in most outcomes, except for a higher frequency of biologic use in non-obese patients with CD (P=0.028). There was a trend toward a greater number of years with active disease in obese patients with CD (P=0.062). CONCLUSION: IBD patients with obesity were predominantly female. Among those with CD, the phenotype was mainly non-stricturing, non-penetrating, with a clinical course characterized by greater disease activity over time, suggesting that obesity may be an unfavorable factor for disease control. This trend was not observed among patients with UC.Roberta Oliveira Raimundo Borsato; Júlio Maria Fonseca Chebli; Tarsila Campanha da Rocha Ribeiro; Luiz Henrique Silva Borsato; Monara Pauletto Sales; M Barra

Inflammatory bowel disease; Ulcerative colitis; Incidence (geometry); Cohort; Retrospective cohort study; Referral; Obesity; Disease; Medical record; Medicine; Internal medicine; Crohn's disease; Cohort study; Outpatient clinic; Epidemiology; Body mass index; Observational study

2026-01-01https://doi.org/10.1590/s0004-2803.24612025-093Arquivos de Gastroenterologia 20261Effect of Plyometric Jump Training on Vertical Jump Indicators and Performance-Related General Physical Fitness in Rugby Players: A Systematic ReviewINTRODUCTION: Vertical jump performance is linked to key performance indicators in rugby, including tackling success and ruck involvement. Although plyometric jump training (PJT) is known to enhance explosive qualities in various sports, its specific effects in rugby remain unclear. OBJECTIVE: To synthesise evidence on the effects of PJT on vertical jump ability and other physical fitness components in adult rugby players. METHODS: A systematic review was conducted in accordance with PRISMA 2020 guidelines. PubMed, EBSCO (SPORTDiscus), WoS, and Scopus were searched up to December 2025. Experimental and quasi-experimental studies involving rugby players undertaking PJT programmes of at least two weeks, with at least one vertical jump outcome, were included. Two reviewers independently performed study selection and data extraction. Risk of bias was assessed using the RoB 2.0 tool. RESULTS: Seven studies involving 178 male players were included. PJT improved sprint speed, change of direction, anaerobic power, reactive strength, lower-limb stiffness, and isometric plantar flexion strength. Gains in countermovement jump power were noted in some conditions, such as training on softer surfaces. However, improvements in jump height were inconsistent. CONCLUSION: PJT enhances several important physical qualities in rugby players but shows variable effects on vertical jump height. Further high-quality research is needed.Javier Russell‐Guzmán; Sebastián Moraga-Moraga; Alexis Espinoza-Salinas; Felipe Inostroza-Ríos; Claudio Carvajal-Parodi; Francisco Guede-Rojas; David Ulloa-Díaz; Jorge Perez-Contreras

Plyometrics; Vertical jump; Jump; Sprint; Isometric exercise; Physical fitness; Basketball; Countermovement; Physical medicine and rehabilitation; Mathematics; Physical therapy; Stretch shortening cycle; Psychology; Jumping; Training (meteorology)

2026-05-21https://doi.org/10.3390/life16050859Life 20261ASSOCIATION BETWEEN HIV INFECTION AND ONCOGENIC HPV SUBTYPES IN CISGENDER WOMENIntroduction: Women living with HIV/AIDS (WLHA) are more vulnerable to human papillomavirus (HPV) infection, particularly by high-risk oncogenic subtypes, due to HIV-associated immunosuppression. Objective: To assess the prevalence and distribution profile of HPV subtypes in WLHA, correlating findings with CD4 levels and age group. Methods: A cross-sectional study was conducted with 184 WLHA receiving care at a public referral center in Juiz de Fora, Minas Gerais, from May 2021 to May 2022. Self-collected vaginal samples were analyzed by RT-PCR to detect HPV subtypes. Associations between HPV infection, CD4 counts, and age were assessed using the chi-square test (p<0.05). Results: HPV infection was detected in 72% of the participants. Oncogenic subtypes not included in the quadrivalent vaccine were identified in 49.3% of the infected individuals, with HPV 52 and 58 being the most prevalent. A higher frequency of infection was observed in women with CD4 counts <500 cells/mm³, although no statistical association was found between CD4 levels and specific viral types. There was no significant association between age and the prevalence of major subtypes. Conclusion: WLHA show a high prevalence of HPV, particularly high-risk subtypes not covered by the quadrivalent vaccine. The findings support expanding immunization with the nonavalent vaccine and strengthening cervical cancer screening and control strategies in this population.Sarah Moreira de Sousa Gomes; Paulo César Apolinário de Souza; Cassiane Freitas Rodrigues; Yago Vieira de Oliveira Almeida; Marcos de Assis Moura; Angélica Espinosa Miranda; Maria Luíza Bazzo; Pâmela Cristina Gaspar; Mariângela Freitas da Silveira

Cervical cancer; HPV infection; Human papillomavirus; Human immunodeficiency virus (HIV); Lentivirus; Cancer; Public health; Referral; Medicine; Immunology; Internal medicine; Viral disease; Virology; Papillomaviridae; Oncology

2026-05-22https://doi.org/10.5327/dst-2177-8264-1457Jornal Brasileiro de Doenças Sexualmente Transmissíveis 20261Efeitos de um programa de exercícios terapêuticos em grupo em adultos de meia-idade e idosos em uma unidade básica de saúde de Minas GeraisIntrodução: Os exercícios terapêuticos em grupo são amplamente utilizados na Atenção Primária à Saúde (APS), no entanto, permanecem lacunas quanto à sua efetividade na prática clínica. Objetivo: Investigar os efeitos de um programa de exercícios terapêuticos em grupo, com duração de 8 semanas, sobre testes funcionais, dor e força de preensão manual (FPM) em usuários assistidos por uma Unidade Básica de Saúde (UBS) na cidade de Juiz de Fora, Minas Gerais. Material e Métodos: Estudo quase experimental, com amostra por conveniência. Foram realizadas avaliações pré e pós intervenção sobre a capacidade funcional por meio dos testes Timed Up and Go (TUG), teste de sentar e levantar de 30 segundos (TSL) e teste de Caminhada de 6 minutos (TC6), dor (Escala Numérica de Dor - END) e FPM (Dinamômetro hidráulico Saehan®). A comparação antes e pós-intervenção foi realizada através do teste t de Student pareado para variáveis paramétricas e do teste de Wilcoxon para não paramétricas, utilizando o software SPSS 22.0, adotando-se nível de significância de p ≤ 0,05. Adicionalmente, foi realizada análise estratificada por sexo (TUG, TSL e FPM). Resultados: Participaram 25 indivíduos (16 mulheres e 9 homens), com média de idade de 67,28 ± 9,51 anos. Houve melhora no TSL (10,52 ± 2,52 para 11,90 ± 2,80 segundos; p=0,001; d=0,74) e no TUG (9,77 ± 3,07 para 8,44 ± 2,20 segundos; p=0,002; d=0,68), além de redução da dor nos membros inferiores (END: 1 [0–5] para 0 [0–1]; p=0,014; d=0,84). Não foram observadas diferenças significativas para FPM (direita: p=0,97; esquerda: p=0,10) e TC6 (410 [351–477] para 405 [374–480] metros; p=0,70). Conclusão: O programa de exercícios em grupo por 8 semanas, na APS, apresentou melhora da capacidade funcional e redução da dor nos membros inferiores, sem impacto na capacidade aeróbica e na FPM.Vandressa Silva de Almeida; Andressa Costa da Silva; Giovani Bernardo Costa; Cyntia Pace Schmitz Corrêa; Maycon Moura Reboredo; Diogo Simões Fonseca; Priscila Monteiro Veras

Wilcoxon signed-rank test; Test (biology); Statistical analysis; Elderly people; Context (archaeology); Medicine; Gynecology; Humanities

2026-05-01https://doaj.org/article/ba14c0c63dc1407f98f6b4d2c13db1adDOAJ (DOAJ: Directory of Open Access Journals) 20261Measurement of the Higgs boson production in association with top quarks in multilepton final states in pp collisions at √s = 13 TeV with the ATLAS detectornull, null; G. Aad; Aakvaag, E.; Abbott, B.; Abdelhameed, S.; Abeling, K.; Abicht, N. J.; Abidi, S. H.; Aboelela, M.; Aboulhorma, A.; Abramowicz, H.; Acharya, B. S.; Ackermann, A.; Adam Bourdarios, C.; Adamczyk, L.; Addepalli, S. V.; Addison, M. J.; Adelman, J.; Adiguzel, A.; Adye, T.; Affolder, A. A.; Afik, Y.; Agaras, M. N.; Aggarwal, A.; Agheorghiesei, C.; Ahmadov, F.; Ahuja, S.; Ahuja, S.; Ai, X.; Aielli, G.; Aikot, A.; Ait Tamlihat, M.; Aitbenchikh, B.; Åkesson, T. P. A.; Akiyama, D.; Akolkar, N. N.; Aktas, S.; Alberghi, G. L.; Albert, J.; Alberti, U.; Albicocco, P.; Albouy, G. L.; Alderweireldt, S.; Alegria, Z. L.; Aleksa, M.; Alexa, C.; Aleksandrov, I. N.; Alexopoulos, T.; Alfonsi, F.; Algren, M.; Alhroob, M.; Ali, B.; Ali, H. M. J.; Ali, S.; Alibocus, S. W.; Aliev, M.; Alimonti, G.; Alkakhi, W.; Allaire, C.; Allbrooke, B. M. M.; Allen, D. R.; Allen, J. S.; Allen, J. F.; Aloisio, A.; Alonso, F.; Alpigiani, C.; Alsolami, Z. M. K.; Alvarez Fernandez, A.; Alves Cardoso, M.; Alviggi, M. G.; Aly, M.; Ambler, A.; Amelung, C.; Amerl, M.; Ames, C. G.; Amezza, T.; Amini, B.; Amirie, K.; Amirkhanov, A.; Amor Dos Santos, S. P.; Amperiadou, D.; An, S.; Anastopoulos, C.; Andeen, T.; Anders, J. K.; Anderson, A. C.; Andreazza, A.; Angelidakis, S.; Angerami, A.; Anisenkov, A. V.; Annovi, A.; Antel, C.; Antipov, E.; Antonelli, M.; Anulli, F.; Aoki, M.; Aoki, T.; Aparo, M. A.; Aperio Bella, L.; Apicella, M.

Higgs boson; Large Hadron Collider; Yukawa potential; Lepton; Top quark; Boson; Standard Model (mathematical formulation); ATLAS experiment; Atlas (anatomy); Particle physics; Physics; Nuclear physics; Pair production; Quark; Luminosity; Hadron; Detector; Coupling (piping); Production (economics); Elementary particle; Bottom quark

2026-01-01https://www.research.ed.ac.uk/en/publications/0de247b6-8f86-4be3-9e26-06d918c98d87Edinburgh Research Explorer 20261Ensinar física como prática de liberdade: 60 anos da Sociedade Brasileira de Física e 30 anos da Pedagogia da AutonomiaEste editorial celebra dois marcos centrais para a educação científica brasileira: os 60 anos da Sociedade Brasileira de Física (SBF) e os 30 anos da publicação de Pedagogia da Autonomia: Saberes Necessários à Prática Educativa, de Paulo Freire. A partir dessa dupla homenagem, o texto reafirma o compromisso histórico da SBF com o ensino de física e destaca o papel da revista A Física na Escola como espaço privilegiado de diálogo entre pesquisa acadêmica, escola básica e reflexão crítica. Inspirado no pensamento freiriano, o editorial defende o ensino de física como prática de liberdade, articulando rigor conceitual, escuta dos estudantes, reflexão crítica e responsabilidade social. Ao dialogar com abordagens contemporâneas que relacionam Física, justiça social e problematização da realidade, o texto sustenta que ensinar Física vai além da transmissão de conteúdos: trata-se de formar sujeitos capazes de compreender criticamente o mundo e de nele intervir. Assim, esta celebração assume também o caráter de convite à revisão da práxis educativa e à renovação do compromisso com uma educação científica ética, dialógica e emancipadora.Marlon C. Alcantara; Paulo Henrique Dias Menezes

Autonomy; Field (mathematics); Democracy; Work (physics); Philosophy; Sociology; Humanities; Political science; Epistemology

2026-05-26https://doi.org/10.59727/fne.v24i1.449A Física na Escola 20261Raman Spectroscopic Characterization of Carotenoid and Phenolic Co-Occurrence in Euphorbia pulcherrima Bracts and InflorescencesThe present study investigated the carotenoid content in colored bracts, nectar gland, flowers, and pollen of Euphorbia pulcherrima (poinsettia) using Raman spectroscopy. Raman spectra obtained from in situ and crude extracts of the structural components were attributed to carotenoids, phenolic acids, flavonoids, and anthocyanins. Significant changes in the spectral profile were observed according to the bract´s color variation. In the green leaves, bands assigned to carotenoids presented a higher intensity when compared to the main bands ascribed to phenolic acids/polyphenols. Intensity ratios involving ν(C=C) mode at 1527 cm –1 , from carotenoids and ν(C=C) ar at 1600 cm –1 , from polyphenols decreases in the following order: green leaves (I car /I pol = 1.89), yellow (I car /I pol = 0.72), red (I car /I pol = 0.4), and pink bracts (I car /I pol = 0.3). No carotenoid band was detected in white bracts. Raman mapping performed with bracts in transition of the coloration from green to red revealed that both carotenoids and phenolic compounds occur throughout the adaxial surface, but with different color gradients according to the development of the bract. The analysis of the inflorescences showed that carotenoids were the main pigments responsible for the coloration of the yellow nectar gland and pollen grains, while bracts and flowers (pedicel and style) had a predominance of polyphenols. We also used Raman spectroscopy to characterize the efficiency of crude extracts of green leaves and red bract as a reducing agent in the synthesis of silver nanoparticles (AgNPs). The red bract acetone crude extract yielded the most intense localized surface plasmon resonance (LSPR) signals. This work demonstrates the dual utility of E. pulcherrima bracts: as a source of diverse phytochemicals and as a sustainable route to biologically active nanostructured materials.Lenize F. Maia; Mariana T. C. Campos; Rafael de Oliveira; Howell G. M. Edwards; Eudes da S. Velozo; Antonio Carlos Sant’Ana; Luiz F. C. de Oliveira

Bract; Carotenoid; Raman spectroscopy; Pigment; Nectar; Polyphenol; Chemistry; Botany; Food science; Pollen; Acetone; Inflorescence

2026-05-26https://doi.org/10.1177/00037028261453405Applied Spectroscopy 20261An OpenFOAM based solver for three-phase flow in porous media incorporating foam effectsFoam injection is a promising alternative for enhanced oil recovery strategies, as it can improve sweep efficiency in gas-assisted processes. Accurately predicting multiphase foam flow in porous media, however, remains challenging, and existing modeling approaches continue to evolve as new foam modeling insights and numerical strategies emerge. In this work, we develop ImpesFOAM, a computational framework for three-phase flow incorporating effects of foam using {Finite volume method} (FVM) formulation within the OpenFOAM framework and {IMplicit-Pressure Explicit-Saturation} (IMPES) method. Two foam formulations are incorporated: an implicit-texture model that captures dry-out, oil effects, and surfactant concentration, and a mechanistic population-balance model describing bubble generation and coalescence. Surfactant transport in the aqueous phase is modeled through an additional conservation equation that includes adsorption effects. The object-oriented high-level programming design of OpenFOAM facilitates the link between mathematical modeling and computational implementation, which makes the developed solver more flexible for further foam model implementations. The solver is validated against a comprehensive set of benchmark cases for two and three-phase flow, with and without foam, designed to isolate gravity, capillary pressure, well-driven flow with source and sink terms, and surfactant transport mechanisms. The results show good agreement with analytical, numerical, and experimental results. Moreover, through two three-dimensional field application cases, we demonstrate that foam-assisted {Enhanced Oil Recovery} (EOR) ultimately yields more economically attractive outcomes, including a substantial increase in oil recovery factor and a decrease in the gas-oil ratio production.Anderson Ribeiro; Grigori Chapiro; Bernardo Martins Rocha; Rodrigo Weber dos Santos

Solver; Porous medium; Enhanced oil recovery; Bubble; Multiphase flow; Benchmark (surveying); Flow (mathematics); Computational fluid dynamics; Capillary action; Computer science; Pulmonary surfactant; Process engineering; Mechanics; Materials science; Porosity; Two-phase flow

2026-05-26https://doi.org/10.17632/9h89bzphmrMendeley Data 20261Tratamentos Atuais não Invasivos para Hipersensibilidade Dentinária: Revisão IntegrativaIntrodução: A hipersensibilidade dentinária (HD) é uma condição cada vez mais frequente na prática clínica odontológica, caracterizada por uma dor aguda e de curta duração em resposta a estímulos térmicos, táteis, osmóticos e químicos, geralmente associada à exposição da dentina. Seu manejo clínico deve considerar a natureza multifatorial de sua etiologia. Objetivo: realizar uma revisão integrativa da literatura sobre os tratamentos atuais não invasivos para o controle da HD. Material e método: estratégias de busca foram elaboradas para as bases de dados PubMed, SciELO e Biblioteca Virtual em Saúde (BVS). Foram incluídos artigos publicados entre 2020 a 2025. Resultados: 21 estudos foram incluídos na revisão. Os principais tratamentos aplicados para HD foram vernizes fluoretados, selantes, adesivos, dessensibilizantes à base de oxalato de potássio, nitrato de potássio e glutaraldeído, além de cremes dentais dessensibilizantes. Também foram relatadas terapias com laser de baixa e alta potência, ozonioterapia e associações entre diferentes abordagens. Conclusão: diversas estratégias terapêuticas têm sido utilizadas para o controle da HD, com resultados variados. A laserterapia destaca-se como uma alternativa promissora, atuando tanto na modulação da dor quanto na redução da permeabilidade dentinária. Quando associada a outros agentes dessensibilizantes, pode potencializar os resultados clínicos, contribuindo para maior eficácia no tratamento da HD.Gabriela Silva Rossi; Rafael Resende de Miranda; Veridiana Resende Novais; Allyne Jorcelino Daloia de Carvalho

SciELO; Polypharmacy; Cryoglobulinemia; Humanities; Medicine; Philosophy

2026-05-25https://doi.org/10.21270/archi.v15i5.6785ARCHIVES OF HEALTH INVESTIGATION 20261International trade in environmental goods: the effects of import tariffs on renewable energy innovationThe 2001 Doha Ministerial Declaration (DMD) established a critical nexus between trade and the environment by advocating for the reduction or elimination of tariff and non-tariff barriers on environmental goods. This paper empirically examines whether import tariffs on these goods hinder renewable energy innovation from 2005 to 2015. Using panel data for 62 countries from the OECD and World Bank, we apply a Two-Stage Least Squares (2SLS) regression to address potential endogeneity. The results indicate that a one-percentage-point increase in import tariffs is associated with an approximate 5.1% reduction in renewable energy innovations. Furthermore, the effects of tariff reductions differ between developed and developing countries: while advanced economies exhibit a stronger innovation response, developing nations show more modest gains, reflecting disparities in research capacity and institutional support. These findings underscore the role of trade liberalization in fostering eco-innovation and offer actionable insights for policymakers: reducing tariff barriers on environmental goods can accelerate technological diffusion, strengthen national innovation systems, and enhance the competitiveness of renewable energy sectors.Key Policy HighlightsReducing import tariffs on environmental goods significantly increases renewable energy innovation, highlighting the role of trade liberalization in supporting low-carbon technological development.Lower trade barriers facilitate access to clean technologies, accelerating technology diffusion and strengthening countries’ innovation capacity in renewable energy sectors.The innovation effects are stronger in advanced economies, while developing countries require complementary policies, such as investments in R&D and institutional capacity, to fully realize these gains.Trade liberalization should be integrated with innovation policies to maximize its impact on renewable energy development and support the transition to sustainable energy systems.Amanda Leone Rodrigues; Rosa Lívia Gonçalves Montenegro; Cláudio Roberto Fóffano Vasconcelos

Renewable energy; Trade barrier; International trade and water; Energy (signal processing); Porter hypothesis; Free trade; International trade; Economics; International economics; Natural resource economics; Business

2026-05-26https://doi.org/10.1080/21606544.2026.2667148Journal of Environmental Economics and Policy 20261Explainable AI (XAI) in Decision Support for Mitigating Carbon Emissions in Agriculture: A Systematic ReviewPedro C. Almeida; Davi Domingues; Regina Braga; José David; Barbara Quintela

Decision support system; Greenhouse gas; Carbon fibers; Air pollution; Sustainability; Environmental science; Computer science; Risk analysis (engineering)

2026-01-01https://doi.org/10.5220/0015044100004018 20261El Imperialismo en el Capitalismo Global: aportaciones analíticas desde un diálogo entre Lenin, Samir Amin y David HarveyLa comprensión del imperialismo es fundamental para interpretar las desigualdades globales, aunque su análisis actual exige revisar la evolución del concepto a la luz de las nuevas configuraciones del capital. El objetivo de este artículo es realizar un análisis teórico-comparativo de las concepciones de imperialismo en las obras de Vladimir Lenin, Samir Amin y David Harvey, identificando sus continuidades, rupturas y actualizaciones. Metodológicamente, se define como una revisión teórico-comparativa de carácter histórico-conceptual, sustentada en una investigación bibliográfica cualitativa de las fuentes primarias y secundarias de los autores seleccionados. El procedimiento consistió en contrastar la sistematización clásica de Lenin (fase superior y capital financiero), la relectura de Amin (etapa permanente y ley del valor globalizado) y la propuesta de Harvey (nuevo imperialismo y acumulación por desposesión). Los resultados revelan convergencias en la inherencia del imperialismo al sistema capitalista, pero señalan divergencias significativas en su temporalidad y en los mecanismos específicos de dominación. Se concluye que la integración de estas perspectivas ofrece un marco analítico robusto para comprender las dinámicas de poder contemporáneas, aportando una visión sofisticada sobre la desigualdad en el capitalismo global.Gabriel Oliveira; Thiago Duarte Pimentel

Capital (architecture); Capitalism; Context (archaeology); Inequality; Power (physics); Humanities; Philosophy; Political science

2026-05-26https://doi.org/10.22403/uqroomx/typ35/11Revista Teoría y praxis 20261Educação Física na área das linguagens: A percepção dos professores da rede municipal de Juiz de ForaA Educação Física, tradicionalmente voltada ao desenvolvimento motor e à saúde, enfrenta desafios ao se integrar à área das Linguagens no currículo escolar, sendo muitas vezes vista de forma isolada. A inclusão dessa disciplina na área das Linguagens, pelos Parâmetros Curriculares Nacionais e pela BNCC, evidenciou a conexão entre corpo, cultura e identidade. No entanto, muitos professores ainda têm dificuldades em compreender essa relação. Com isso, o presente estudo buscou analisar como professores de Educação Física da rede municipal de Juiz de Fora compreendem a Educação Física na área das Linguagens. Realizou-se uma pesquisa qualitativa de natureza interpretativa em que, o pesquisador realizou entrevistas semiestruturadas com sete professores da rede municipal de ensino de Juiz de Fora, utilizando a análise de conteúdo para interpretação dos dados. Os resultados evidenciaram que, apesar das lacunas presentes na formação inicial, os professores participantes compreendem a Educação Física como integrante da área das Linguagens, reconhecendo as práticas corporais como manifestações culturais e formas de expressão. As experiências profissionais, os espaços formativos e a BNCC foram apontados como elementos importantes para ampliar essa compreensão. As práticas pedagógicas analisadas também revelaram valorização da diversidade cultural, inclusão e problematização de questões sociais, como gênero, racismo e pertencimento. Assim, conclui-se que a inserção da Educação Física na área das Linguagens representa uma ampliação do papel formativo da disciplina, compreendendo as práticas corporais para além do desempenho físico.Rafael Loures dos Reis Bellei; Ayra Lovisi; Wilson Alviano Júnior; Guilherme Henrique Bibiano Honório; Renata Barbosa Rodrigues

Hate crime; Ethnography; School violence; Humanities; Sociology; Political science

2026-05-22https://doi.org/10.33448/rsd-v15i5.51118Research Society and Development 20261Dietary polyphenols as modulators of the microbiota–gut–brain axis in depression and anxiety: a preclinical perspectiveMood and anxiety disorders are increasingly prevalent conditions, and growing evidence indicates that the gut microbiota plays a central role in their pathophysiology through the microbiota-gut-brain axis. This review summarizes the current preclinical evidence of the effects of dietary polyphenols on this axis and their implications for mood regulation, while also discussing their translational relevance based on human-equivalent dose estimations and available clinical findings. Overall, the literature supports that polyphenols modulate the gut microbial composition and diversity, promote beneficial bacterial groups, and alter microbiota-derived metabolites, particularly short-chain fatty acids, while improving the gut barrier integrity and reducing systemic and neuroinflammatory processes. These microbiota-related changes were often associated with alterations in neurotransmitter systems, neurotrophic factors, and markers of synaptic plasticity, resulting in improvements in depressive- and anxiety-like behaviors and, in some cases, cognitive performance in animal models. Correlation analyses further strengthen the links between specific microbial taxa, metabolites, and neurobehavioral outcomes, reinforcing the relevance of gut microbiota modulation as a determinant pathway. In addition, dose translation analyses reveal substantial variability in dietary feasibility, and clinical studies, although limited, generally support beneficial effects on mood-related outcomes. Collectively, these findings highlight dietary polyphenols as promising modulators of the microbiota-gut-brain axis and emphasize their relevance for future nutritional strategies targeting mood-related disorders.Levi Nascimento Bellinazzi; Iara Lopes Lemos; Ágatta Caroline de Souza; Giulianna Genizelli; Ângela Giovana Batista; Mário Roberto MARÓSTICA JÚNIOR

Polyphenol; Perspective (graphical); Depression (economics); Neurotransmission; Gut–brain axis; Gut flora; Pharmacology; Medicine; Bioinformatics

2026-01-01https://doi.org/10.1039/d5fo05615bFood & Function 20261An OpenFOAM based solver for three-phase flow in porous media incorporating foam effectsFoam injection is a promising alternative for enhanced oil recovery strategies, as it can improve sweep efficiency in gas-assisted processes. Accurately predicting multiphase foam flow in porous media, however, remains challenging, and existing modeling approaches continue to evolve as new foam modeling insights and numerical strategies emerge. In this work, we develop ImpesFOAM, a computational framework for three-phase flow incorporating effects of foam using {Finite volume method} (FVM) formulation within the OpenFOAM framework and {IMplicit-Pressure Explicit-Saturation} (IMPES) method. Two foam formulations are incorporated: an implicit-texture model that captures dry-out, oil effects, and surfactant concentration, and a mechanistic population-balance model describing bubble generation and coalescence. Surfactant transport in the aqueous phase is modeled through an additional conservation equation that includes adsorption effects. The object-oriented high-level programming design of OpenFOAM facilitates the link between mathematical modeling and computational implementation, which makes the developed solver more flexible for further foam model implementations. The solver is validated against a comprehensive set of benchmark cases for two and three-phase flow, with and without foam, designed to isolate gravity, capillary pressure, well-driven flow with source and sink terms, and surfactant transport mechanisms. The results show good agreement with analytical, numerical, and experimental results. Moreover, through two three-dimensional field application cases, we demonstrate that foam-assisted {Enhanced Oil Recovery} (EOR) ultimately yields more economically attractive outcomes, including a substantial increase in oil recovery factor and a decrease in the gas-oil ratio production.Anderson Ribeiro; Grigori Chapiro; Bernardo Martins Rocha; Rodrigo Weber dos Santos

2026-05-26https://doi.org/10.17632/9h89bzphmr.1Mendeley Data 20261Mudanças climáticas, saúde indígena e migrações ambientais no contexto do bioma Amazônia: impactos sobre povos indígenas situados na TI Alto Rio NegroO objetivo do estudo foi analisar os impactos das mudanças climáticas e alterações ambientais na situação de vida, saúde e migrações das populações indígenas do Território Indígena Alto Rio Negro/AM. A metodologia foi cartografia social, método PVP e história oral. Os resultados indicam que as mudanças ambientais acarretam contaminação das águas e do solo, escassez de pesca e caça, ausência de acesso à água potável, acúmulo de resíduos sólidos, perda da soberania alimentar, propagação de doenças e migrações ambientais. O enfrentamento de tais questões exige a transformação do modelo de desenvolvimento e da lógica extrativista.Denise Osório Severo; Juçara Menezes Alencar Menezes Alencar; Ieda Maria Vargas; Maria da Graça Luderitz Hoefel

Context (archaeology); Work (physics); Amazon rainforest; Field research; Sustainability; Natural resource; Field (mathematics); Geography; Indigenous; Political science

2026-04-28https://doi.org/10.31423/oikos.v37i1.22259Oikos Família e Sociedade em Debate 20261Spacetime Densification Theory and the Newtonian limitAbstract We develop an effective scalar-field theory for a coherent spacetime substrate whose long-wavelength response reproduces Newtonian gravity. The substrate is represented at macroscopic scales by a scalar density field coupled universally to standard matter through an effective metric whose leading conformal sector generates the Newtonian limit and whose disformal sector defines higher-gradient viability constraints, . The microscopic equation of state of the substrate is taken from companion work and is not derived here. We obtain the linearized field equation for the density perturbation around a homogeneous background, identify a Poisson-like source law , and show that the gradient of the substrate density acts on matter through an effective force . The Newtonian limit is recovered exactly when the two response coefficients satisfy the calibration condition . A benchmark thermodynamic closure for maps these coefficients to substrate parameters, reducing the calibration to a constraint on one microscopic combination rather than an arbitrary split of . The tensorial Einstein–Hilbert sector is not derived, but imposed as an infrared matching condition required for relativistic consistency. We formulate the matching prescription that prevents double counting: the densification potential and the infrared Newtonian potential are identified as the same object, not additive. Disformal and higher-derivative corrections, together with post-Newtonian and multi-messenger constraints, are characterized as viability conditions on the effective parameter space rather than as derived predictions. No claims are made in this paper concerning post-Newtonian observables, gravitational waves, galactic phenomenology, or strong-field dynamics; these are deferred to companion work. Keywords: emergent gravity; effective field theory; disformal coupling; Newtonian limit; induced gravity; infrared matching; scalar–tensor theories.Paulo G.A. Suassuna

2026-05-26https://doi.org/10.5281/zenodo.20395578Zenodo (CERN European Organization for Nuclear Research) 20261Pre-Competition Anxiety and Mood State in White-Belt Brazilian Jiu-Jitsu Athletes: An Exploratory Comparison Between Medalists and Non-MedalistsBackground: Combat sports performance is highly determined by psychological factors, and differences in pre-competitive anxiety and mood states can exist between medalist and non-medalists athletes; Methods: The present study aims to assess pre-competitive anxiety and mood state differences between medalist and non-medalists Brazilian Jiu-Jitsu (BJJ) athletes graded as white-belts. The Competitive State Anxiety Inventory–2 (CSAI-2) and the Brunel Mood Scale (BRUMS) questionnaires were applied to 26 BJJ white-belt athletes before a fight in a national-level competition.; Results: Medalists presented less cognitive anxiety (22.36 ± 3.82 vs. 25.21 ± 3.17; p < 0.05) and higher mental confusion (9.86 ± 3.01 vs. 7.43 ± 3.01; p < 0.05) than non-medalist athletes. No significant differences were found in any other variable; Conclusions: The relationship between pre-competitive anxiety and sport performance is clear; however, higher mental confusion in medalists is a confounding result. More research is needed on this topic to elucidate the psychological phenomena of higher mental confusion in less-experienced athletes.Marcelo Victor Menezes Santana; Felipe J. Aidar; Renato Méndez-delCanto; Márcio Getirana-Mota; Alfonso López Díaz de Durana; Rapahel Fabricio de Souza; Ciro José Brito; Teresa Figueiredo; Luís Leitão

Anxiety; Confusion; Mood; Athletes; Exploratory research; Profile of mood states; Psychology; Clinical psychology; Cognition; Psychiatry; Confounding

2026-05-26https://doi.org/10.3390/sports14060216Sports 20261Dataset of IoT Monitoring and Energy Consumption in a Smart Laboratory for EducationRodrigo Mendes Peixoto

Energy consumption; Internet of Things; Energy (signal processing); Consumption (sociology); Data collection; Key (lock); Computer science; Real-time computing

2026-05-27https://doi.org/10.5281/zenodo.20412333Zenodo (CERN European Organization for Nuclear Research) 20261PERFIL NOSOLÓGICO DAS DERMATOSES EM PACIENTES DO SEXO FEMININO DA ATENÇÃO PRIMÁRIA DE GOVERNADOR VALADARESAs doenças dermatológicas afetam 1,9 bilhão de pessoas no mundo, sendo considerado um grande problema de saúde pública, especialmente na atenção primária à saúde (APS). A pele, além de apresentar doenças próprias, é um importante local de manifestação cutânea de doença sistêmica e esse entendimento é fundamental para impedir diagnósticos e tratamentos inadequados. Este estudo teve como objetivo principal descrever as principais dermatoses encontradas em pacientes do sexo feminino da Atenção Primária de Governador Valadares. Para isso, realizou-se um estudo transversal com 48 mulheres encaminhadas para avaliação dermatológica em uma Unidade Básica de Saúde. O diagnóstico foi clínico, com biópsia cutânea em seis casos (12,5%) para confirmação. Foram identificadas 29 condições distintas. As mais frequentes foram queratose seborreica (12,5%), dermatite de contato alérgica (8,3%), acne e psoríase (6,3% cada). O perfil evidenciou grande diversidade, com a presença de neoplasias (benignas e malignas), doenças infecciosas (como hanseníase e esporotricose) e afecções inflamatórias crônicas. Conclui-se que o espectro dermatológico na APS é amplo e complexo, exigindo dos profissionais capacidade de suspeição para condições comuns, raras e potencialmente graves. O conhecimento desse perfil é fundamental para uma abordagem assertiva, um encaminhamento criterioso e o manejo eficaz na porta de entrada do sistema.Itália Aparecida dos Santos Zanelli; Marcílio Zanelli Pereira; Pedro Henrique Berbert de Carvalho; Heder José Ribeiro; Karine Beatriz Costa

Skin lesion; Interpretation (philosophy); Acne; Perspective (graphical); Gynecology; Medicine; Philosophy

2026-05-27https://doi.org/10.66104/vpa4gg15Revista Multidisciplinar do Nordeste Mineiro 20261AUTOGESTÃO DO TRABALHO ASSOCIADO: FUNDAMENTOS PARA UMA PROPOSTA METODOLÓGICA NA EXTENSÃO UNIVERSITÁRIA EM ADMINISTRAÇÃOO texto tem como objetivo propor a autogestão como fundamento teórico para a elaboração de um método extensionista aos cursos de Administração no Brasil. As mudanças regulamentadas pelas diretrizes para a extensão na educação superior brasileira tornam possíveis reestruturações importantes na atuação extensionista de seus cursos. Pautado na recíproca relação sociedade e universidade, tal método se propõe a aproveitar as estruturas universitárias na promoção e potencialização de sua capacidade de inserção, comunicação e intervenção social. Partindo do materialismo, o texto argumenta que a autogestão serve como princípio teórico no desenvolvimento de um método adequado à análise de problemas, criação e experimentação inovativa e fortalecimento de formas alternativas da organização do trabalho associado, propiciando interação efetiva entre as potencialidades do tripé ensino, pesquisa e extensão das universidades na promoção da autogestão.Henrique Almeida de Queiroz

Field (mathematics); Perspective (graphical); Order (exchange); Work (physics); Representation (politics); Humanities; Philosophy; Epistemology

2026-05-27https://doi.org/10.1590/scielopreprints.16251 20261Apropriação de dados educacionais na Gestão Escolar Democrática: o papel dos supervisores escolares nas escolas prioritárias do Espírito SantoEste artigo analisa os desafios enfrentados por supervisores escolares no uso e na apropriação de dados educacionais no assessoramento às escolas prioritárias da rede pública estadual do Espírito Santo. O estudo busca compreender como a Gerência de Ensino Médio da SEDU pode qualificar esse assessoramento, fortalecendo o uso de dados e evidências na tomada de decisão e na melhoria da aprendizagem dos estudantes do Ensino Médio. A investigação foi orientada pelos princípios da Gestão Democrática Participativa, considerando a escuta de supervisores escolares e equipe da Gerência de Ensino Médio como dimensão fundamental para a construção de diagnósticos, análise dos dados e definição de estratégias de assessoramento. Metodologicamente, a pesquisa adotou abordagem qualitativa, complementada por procedimentos quantitativos descritivos, e foi desenvolvida em duas etapas: análise documental de políticas, normativas e diretrizes da SEDU relacionadas ao uso de dados e aos resultados de aprendizagem; e pesquisa empírica com supervisores escolares, por meio de questionário estruturado, com o objetivo de identificar percepções, dificuldades e necessidades formativas. Os resultados evidenciam que o uso e a apropriação qualificada dos dados é limitada por desafios na interpretação dos indicadores pelo supervisor escolar. Diante disso, propõe-se um Plano de Ação Educacional voltado à elaboração de uma Diretriz Pedagógica de Assessoramento às Escolas Prioritárias, com o objetivo de fortalecer a gestão pedagógica e o uso sistemático de dados. Conclui-se que a consolidação de uma gestão escolar orientada por evidências exige formação continuada dos supervisores, instrumentos de apoio, escuta qualificada e maior alinhamento entre os níveis da gestão educacional.Aline de Paula Nunes; Endy de Albuquerque Silva; Ivia Sampaio Zambom; Jacqueline Medeiros Caminoti; Wolmar Marvilla Melo

Work (physics); State (computer science); Public security; Basic education; Pedagogy; Humanities; Political science; Sociology

2026-05-26https://doi.org/10.52641/cadcajv11i6.2879Cadernos Cajuína 20261Postoperative Cystoid Macular Edema After Pars Plana Vitrectomy for Epiretinal Membrane: Incidence, Anatomical and Functional Outcomes, and Response to Intravitreal Dexamethasone ImplantLeonardo Provetti Cunha; Manuela Ferreira Guimarães; Leandro Cabral Zacharias; Rony Carlos Preti; Luciana Virgínia Ferreira Costa-Cunha; Mário Luiz Ribeiro Monteiro

Pars plana; Vitrectomy; Macular edema; Dexamethasone; Visual acuity; Epiretinal membrane; Medicine; Ophthalmology; Implant; Intraocular pressure; Significant difference; Incidence (geometry); Surgery; Complication; Optical coherence tomography

2026-05-27https://doi.org/10.21203/rs.3.rs-9728337/v1Research Square 20261Transient Power System Analysis Using an Adaptive Multi-Stage Holomorphic Embedding With Padé-Based Stability IndicatorsConventional power-system dynamic simulation methods rely predominantly on numerical integration schemes whose efficiency may deteriorate under stiff post-contingency conditions, while existing dynamic holomorphic embedding approaches remain constrained by convergence-radius limitations and the absence of adaptive mechanisms guided by analytical stability information. To address these challenges, this paper proposes an adaptive dynamic simulation framework based on the Multi-Stage Holomorphic Embedding Method (MS-HELM) combined with Padé approximation analysis. In the proposed approach, system dynamic variables are represented through Maclaurin series expansions whose effective convergence region is extended via Padé approximants, enabling explicit analytical trajectory representations through local series propagation. The framework incorporates detailed dynamic models, including synchronous-machine swing equations, excitation systems, turbine governors, and primary and secondary frequency control mechanisms. Two main contributions are introduced: first, an MS-HELM formulation for transient simulation that preserves the holomorphic structure while reducing computational effort relative to conventional dynamic HELM implementations; second, an online stability indicator based on the distance to the nearest Padé pole, augmented with temporal consistency filtering and controller-response awareness for adaptive time-step selection. Validation on IEEE benchmark systems and the Iceland power system demonstrates that the proposed method accurately reproduces post-contingency dynamic behavior while simultaneously improving robustness and reducing computational time by up to 90% relative to reference methods. Additionally, the proposed formulation preserves numerical accuracy comparable to that of the fourth-order Runge–Kutta method, yielding percentage differences below 0.1%.Igor D. Melo; Letícia L. S. de Sousa

Control theory (sociology); Stability (learning theory); Embedding; Transient (computer programming); Electric power system; Transient analysis; Power (physics); Control system; Computer science; Adaptive control; Holomorphic function; Adaptive system; Mathematics; Robustness (evolution); Transient response

2026-01-01https://doi.org/10.1109/access.2026.3697635IEEE Access 20261Federated electricity demand forecasting: A client selection mechanism based on TimeVAE latent representationsArtificial intelligence-based solutions are becoming commonplace in the reality of distribution networks. Low-level demand forecasting, in particular, faces significant challenges in large-scale operations and planning, especially regarding privacy concerns and computational performance. Federated Learning (FL), a decentralized training paradigm, emerges as a promising approach that meets these requirements. However, to ensure the success of this paradigm in highly complex environments, such as those involving distributed energy resources, FL solutions must consider a rational selection of clients. In such environments, full client participation may become computationally costly, making the approach infeasible, while random client selection may lead to incomplete pattern recognition. Other studies suggest clustering strategies relying on pre-existing data. However, in real-world applications, this data may not be available. Given these constraints, this paper presents a representativeness-based method for client selection. Using client-side TimeVAE models, the proposed method performs clustering by utilizing client latent spaces and identifies the best representative of the constructed clusters. Synthetic generation and clustering are evaluated by varying the dimensionality of the latent space and applying different distance metrics. Then, the proposed selection mechanism is evaluated in comparison to full and random client participation, adopted as baseline strategies. The outcomes demonstrate that the proposed method outperforms these baselines in terms of mean squared error, while preserving client privacy. Furthermore, the findings suggest the fidelity of synthetic data generation and the effectiveness of the proposed client selection, indicating its potential usage for power distribution applications with privacy concerns.Paulo Vitor B. Ramos; Walquiria Silva; Luis H. T. Bandória; B. F. Dias; Saulo M. Villela; Hugo Morais

Cluster analysis; Curse of dimensionality; Selection (genetic algorithm); Fidelity; Baseline (sea); Scheme (mathematics); Electricity; Information privacy; Synthetic data; Computer science; Data mining; Artificial intelligence; Machine learning; Distributed generation

2026-05-28https://doi.org/10.1016/j.apenergy.2026.128064Applied Energy 20261Fenpropathrin-Loaded Organic-Inorganic Cellulose Acetate/Laponite Films: Contact Toxicity against Brevicoryne brassicae (Hemiptera: Aphididae)High Resolution Image Download MS PowerPoint Slide The association between organic-inorganic hybrid materials and insecticidal/acaricidal molecules, such as fenpropathrin, has emerged as a promising alternative to conventional agricultural pesticide applications. Therefore, this study aimed to produce a hybrid cellulose acetate and Laponite RD film containing fenpropathrin and to investigate its toxicological effects on Brevicoryne brassicae (Linnaeus, 1758) (Hemiptera: Aphididae). The hybrid films were prepared using the casting method. The mortality of B. brassicae through exposure to the hybrid films and fenpropathrin solutions was verified utilizing bioassays, conducted in the laboratory, and a completely randomized design. The data were compared by Tukey’s test ( p < 0.05). The characterization results are consistent with fenpropathrin incorporation into the films at low loading; however, FEN-specific crystalline features are not resolved in the film patterns, which is expected for amorphous polymer/clay matrices and low active-ingredient content. The dose-response curve showed mortality values greater than 80%, in addition to estimating the lethal concentrations to cause mortality of 50 and 80% of the individuals. The exposure of B. brassicae to the hybrid films resulted in a corrected mortality of 71.5%. This study contributes to more sustainable pest management by demonstrating substantial contact toxicity of fenpropathrin-loaded organic−inorganic films against B. brassicae under laboratory conditions, while highlighting that quantitative release profiling will be addressed in future work.Ruth Hellen Silveira dos Santos; Lorena Alves de Melo Bessa; Martinho Melo Figueiredo; Jader Alves Ferreira; Celly M. S. Izumi; Keyller Bastos Borges; Flávio Lemes Fernandes; Jairo Tronto

Toxicity; Brevicoryne brassicae; Cellulose acetate; Cellulose; Pesticide; Food contact materials; Toxicology; Materials science; Biology; Chemistry

2026-05-28https://doi.org/10.1021/acsagscitech.5c01085ACS Agricultural Science & Technology 20261Measurement of differential t-channel single top (anti)quark production cross-sections at 13 TeV with the ATLAS detectorA bstract The production of single top quarks and top antiquarks via the t -channel exchange of a virtual W boson is measured in proton-proton collisions at a centre-of-mass energy of 13 TeV at the Large Hadron Collider. The full Run 2 data sample recorded with the ATLAS detector in the years 2015–2018 is used, corresponding to an integrated luminosity of 140 fb − 1 . The absolute and normalised production cross-sections are measured differentially as a function of the transverse momentum and absolute rapidity of the top quark and top antiquark. In addition, the ratio of top quark to top antiquark production cross-sections is measured. The measured distributions are compared with next-to-leading-order quantum chromodynamics predictions obtained with different combinations of matrix-element generators, parton-shower programs and proton parton distribution functions, as well as to next-to-next-to-leading-order calculations. Overall, good agreement is observed between the measurements and the theoretical predictions. For most measured distributions, the sensitivity to differences between the predictions is limited by the systematic uncertainties in the measurement. The measured differential distributions are also interpreted in an effective field theory approach to constrain the Wilson-Coefficient $$ {C}_{Qq}^{3,1} $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msubsup> <mml:mi>C</mml:mi> <mml:mi>Qq</mml:mi> <mml:mrow> <mml:mn>3</mml:mn> <mml:mo>,</mml:mo> <mml:mn>1</mml:mn> </mml:mrow> </mml:msubsup> </mml:math> associated with a four-quark operator. The interpretation accounts for the effect of the selection efficiency, which is altered significantly by non-zero contributions from $$ {C}_{Qq}^{3,1} $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msubsup> <mml:mi>C</mml:mi> <mml:mi>Qq</mml:mi> <mml:mrow> <mml:mn>3</mml:mn> <mml:mo>,</mml:mo> <mml:mn>1</mml:mn> </mml:mrow> </mml:msubsup> </mml:math> .G. Aad; E. Aakvaag; B. Abbott; S. Abdelhameed; K. Abeling; N. J. Abicht; S. H. Abidi; M. Aboelela; A. Aboulhorma; H Abramowicz; Y. Abulaiti; B. S. Acharya; A. Ackermann; C. Adam Bourdarios; L. Adamczyk; S. V. Addepalli; M. J. Addison; J. Adelman; A. Adiguzel; T. Adye; A. A. Affolder; Y. Afik; M. N. Agaras; A. Aggarwal; C. Agheorghiesei; F. Ahmadov; S. Ahuja; S. Ahuja; X. Ai; G. Aielli; A. Aikot; M. Ait Tamlihat; B. Aitbenchikh; T. P. A. Åkesson; A. V. Akimov; D. Akiyama; N. N. Akolkar; S. Aktas; G. L. Alberghi; J. Albert; U. Alberti; P. Albicocco; G. L. Albouy; S. Alderweireldt; Z. L. Alegria; M. Aleksa; C. Alexa; I. N. Aleksandrov; T. Alexopoulos; F. Alfonsi; M. Algren; M. Alhroob; B. Ali; H. M. J. Ali; S. Ali; S. W. Alibocus; M. Aliev; G. Alimonti; W. Alkakhi; C. Allaire; B. M. M. Allbrooke; D. R. Allen; J. S. Allen; J. F. Allen; P. P. Allport; A ALOISIO; F. Alonso; C. Alpigiani; Z. M. K. Alsolami; A. Alvarez Fernandez; M. Alves Cardoso; M ALVIGGI; M. Aly; A. Ambler; C. Amelung; M. Amerl; C. G. Ames; T. Amezza; D. Amidei; B. Amini; K. Amirie; A. Amirkhanov; S. P. Amor Dos Santos; K. R. Amos; D. Amperiadou; S. An; C. Anastopoulos; T. Andeen; J. K. Anders; A. C. Anderson; A. Andreazza; S. Angelidakis; A. Angerami; A.V. Anisenkov; A. Annovi; C. Antel; E. Antipov; M. Antonelli; F. Anulli; M. Aoki

Rapidity; Parton; Top quark; Quantum chromodynamics; Boson; Atlas (anatomy); Large Hadron Collider; Quark; Hadron; Physics; Particle physics; Nuclear physics; ATLAS experiment; Detector; Distribution function; Atlas detector; Bottom quark; Production (economics); Luminosity; Standard Model (mathematical formulation); Quantum field theory

2026-05-15https://doi.org/10.1007/jhep05(2026)174Journal of High Energy Physics 20261Development of organic–inorganic hybrid coatings with silica nanoparticles, biopolymers, and clay for onion seeds: a multifunctional strategy for controlling white rotWhite rot, caused by Stromatinia cepivora , remains one of the most challenging soil-borne diseases affecting onion crops due to the long-term persistence of sclerotia and the limited effectiveness of conventional fungicide treatments.Lorena Alves de Melo Bessa; Franciely J. A. Camargos; Amanda M. de Oliveira; Celly Izumi; Everaldo Antônio Lopes; E. Alves; Eduardo Seiti Gomide Mizubuti; Jairo Tronto

White rot; White (mutation); Coating; Materials science; Agronomy; Horticulture

2026-01-01https://doi.org/10.1039/d5ma01038aMaterials Advances 20261Screening CZE–UV Green Method for Acetate, Propionate, Butyrate, and Valerate Analysis in Human Stool for Complementary Gut Dysbiosis DiagnosisABSTRACT Short‐chain fatty acids present relevant function in the human body as fermentation metabolites pathways in the natural intestine microbiota activity. Their evaluations can be useful for indication as biomarkers for gut dysbiosis, provided an important health assessment to physicians by specialized laboratories. In the present work, a capillary zone electrophoresis with indirect ultraviolet (CZE–UV) detection method for simultaneous separation of acetate, propionate, butyrate, and valerate in human stool samples was performed. The background electrolyte consisted of 15 mmol L −1 of tris(hydroxymethyl)aminomethane (TRIS), 12 mmol L −1 of 3,5‐dinitrobenzoic acid (3,5‐DNB) and 0.5 mmol L −1 of cetyltrimethylammonium bromide (CTAB) as buffer at pH 7.5, within run time of 7.5 min. The proposed method resulted in an accuracy of 105.5%, 90.12%, 95.9%, and 86.6% and precision of 12.2%, 8.96%, 8.84%, and 18.3% relative standard deviation (RSD) for acetate, propionate, butyrate, and valerate, respectively. The optimized CZE–UV method was successfully applied as potential complementary analytical tool for gut dysbiosis diagnostic assay at 98 stool samples from patients under investigation of intestine‐related anomalies, combining eco‐friendly, quickness, automated, cost‐effective, and high‐throughput aspects. Furthermore, the method offers educational value by exemplifying how sustainable analytical practices can be integrated into modern laboratory training and the teaching of Green Chemistry principles.Olívia B.O. Moreira; Matheus Miranda Fracetti; Eliane B. T. de Lemos; Jeanette C. F. Less; Lúcio M. de Lemos; Paula Rocha Chellini; Marcone A. L. de Oliveira

Dysbiosis; Valerate; Capillary electrophoresis; Pomace; Gut flora; Fermentation; Electrolyte; Chromatography; Chemistry; Analyte; Bromide; Medicine; Biology

2026-05-28https://doi.org/10.1002/elps.70117Electrophoresis 20261Costurando histórias: Relatos de montagem no documentário brasileiro contemporâneo: Editing Accounts in Contemporary Brazilian DocumentaryBy correlating accounts from contemporary Brazilian film editors and the reflections of Comolli and Amiel, this article investigates documentary editing as a creative, authorial, and handcrafted act. Although with the digitization of cinema editing may appear to lose its artisanal nature, due to the volume of raw material and the endless possible versions of a film, this very nature is, in fact, expanded and re-signified.Tainá Moraes

Digitization; Movie theater; Documentary film; Documentary evidence; History; Visual arts; Art; Art history; Media studies

2026-03-31https://ojs.labcom-ifp.ubi.pt/doc/article/view/1716Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) 20261Multi-Stage Probabilistic Transmission Expansion Planning Under Generation Uncertainty and N-1 Security Using the Pack-Based Grey Wolf OptimizerMulti-Stage Transmission Network Expansion Planning (MS-TNEP) is critical for adapting power grids to long-term renewable integration. However, the simultaneous incorporation of N-1 security, active power losses, and uncertainties regarding the spatial and temporal growth of power generation capacity imposes prohibitive computational complexity. This paper proposes a probabilistic MS-TNEP model evaluated over a 20-year horizon. To overcome this computational intractability, a hybrid decomposition framework is employed. The investment subproblem determines the discrete decisions for network investment via a metaheuristic, while the probabilistic operation subproblem utilizes linear programming to assess the operational feasibility of these decisions under multiple spatial and temporal growth of power generation capacity scenarios, active power losses, and N-1 contingencies. Furthermore, a novel Pack-Based Grey Wolf Optimizer (PBGWO) is introduced. The approach is validated on the Garver and the Southern Brazilian equivalent systems under multiple scenarios for the growth of both wind and conventional power generation capacity. Comparative analysis against the Genetic Algorithm, the standard Grey Wolf Optimizer, and the Whale Optimization Algorithm reveals that PBGWO is a highly competitive approach for MS-TNEP problems, consistently identifying the most cost-effective expansion plan.Edimar José de Oliveira; Lucas Santiago Nepomuceno; Arthur Neves de Paula; Raphael P. B. Poubel; Leonardo Willer de de Oliveira

Probabilistic logic; Electric power system; Wind power; Linear programming; Transmission network; Genetic algorithm; Electricity generation; Decomposition; Power transmission; Mathematical optimization; Computer science; Engineering; Transmission (telecommunications); Power (physics); Capacity planning; AC power; Statistical model

2026-05-28https://doi.org/10.3390/technologies14060329Technologies 20261Effectiveness of sodium–glucose cotransporter 2 inhibitors in patients with metabolic dysfunction-associated steatotic liver disease: systematic review and meta-analysis of randomized controlled trialsMetabolic dysfunction-associated steatotic liver disease (MASLD) is highly prevalent and can progress to cirrhosis and hepatocellular carcinoma. Treatment options are still lacking. We assessed the efficacy of sodium-glucose cotransporter 2 inhibitors (SGLT2i) in MASLD. An updated systematic review and meta-analysis of randomized controlled trials in PubMed, Embase, and Cochrane comparing SGLT2i with placebo or active drugs were conducted. Primary outcomes were controlled attenuation parameter (CAP) and liver stiffness by elastography, and fibrosis-4 (FIB-4) score; secondary outcomes were liver enzymes, metabolic and anthropometric measures, and MRI-PDFF. A subgroup without diabetes mellitus (DM) was analyzed. Twenty-nine randomized clinical trials were included (n = 2443). SGLT2i use significantly reduced liver stiffness [mean difference (MD): -0.47 kPa; 95% confidence interval (CI): -0.88 to -0.07; P = 0.022; I2=75%], CAP (MD: -12.24 dB/m; 95% CI: -20.12 to -4.35; P = 0.002; I2=1%), and FIB-4 (MD: -0.22; 95% CI: -0.38 to -0.06; P = 0.008; I2=84%). Improvements were consistently observed in liver enzymes, including alanine aminotransferase, aspartate aminotransferase, and gamma-glutamyl transferase. In addition, reductions were noted in body weight, visceral adipose tissue, waist circumference, glycated hemoglobin, and homeostatic model assessment of insulin resistance. In the subgroup analysis of patients without DM (n = 257), SGLT2i also significantly reduced aspartate aminotransferase and gamma-glutamyl transferase, as well as anthropometric parameters. SGLT2i improves hepatic, metabolic, and anthropometric parameters in MASLD, including liver stiffness, steatosis, and FIB-4; benefits also occur in non-DM individuals, warranting further trials.Milena Ramos Tomé; Jingying Elena Chen; Alana Vitória Santos de Jesus; Wellgner Fernandes Oliveira Amador; Gustavo Procópio Silva; Igor Boechat Silveira; Arthur Victor de Holanda Sampaio; Guilherme Grossi Lopes Cançado

Randomized controlled trial; Fatty liver; Diabetes mellitus; Placebo; Subgroup analysis; Liver disease; Cirrhosis; Dapagliflozin; Insulin resistance; Medicine; Internal medicine; Gastroenterology; Confidence interval; Metabolic syndrome; Clinical trial

2026-05-11https://doi.org/10.1097/meg.0000000000003196European Journal of Gastroenterology & Hepatology 20261From cumulative points to the ‘Best of Three’ system: a comprehensive analysis of World Taekwondo rule changes and their performance implicationsTaekwondo competition rules underwent profound transformations between 2012 and 2026, driven by the need for transparency and to increase spectator appeal. This study analyzed the regulatory evolution of taekwondo and its impact on match dynamics and performance. To this end, we reviewed official World Taekwondo documents and scientific literature to synthesize changes in scoring, technology, and combat structure. The main results indicated that evolution was marked by the progressive implementation of the Protector Scoring System (PSS), expanding from torso-only in 2012 to head and sock sensors in 2017. The 2022 reform introduced the “Best of Three” system, resetting scores every round and capping at five gam-jeom (penalties) per round. By 2026, updates integrated sensing gloves for punches and a 60 cm “Warning Area” for spatial awareness. Scoring reforms increased the value of complex techniques, such as raising turning head kicks to six points (2026). Penalty frameworks transitioned from a 10-penalty disqualification limit (2017) to a 5-penalty round-loss threshold (2022). Structural changes included the transition to octagonal arenas and streamlining Instant Video Review by removing head-kick reviews when the PSS is used (2026). Analysis of the scientific literature indicates that these regulatory shifts have increased combat intensity, with studies reporting a rise in post-combat lactate levels and higher kinematic demands, forcing athletes to adopt more offensive technical-tactical strategies. In conclusion, the regulatory trajectory has modernized taekwondo into a more dynamic, technologically driven, and physically demanding sport. The shift to independent round scoring and 2026 updates prioritizes explosive performance and spectator clarity, requiring training protocols to adapt to the increased anaerobic and strategic demands.N. Almeida; Esteban Aedo-Muñoz; Diego Valenzuela Pérez; Felipe Aidar; Bianca Miarka; ciro brito

Offensive; Athletes; Transparency (behavior); Forcing (mathematics); Scoring system; Limit (mathematics); Kinematics; Operations research; Computer science; Operations management; Aeronautics; Simulation

2026-05-28https://doi.org/10.18002/rama.v21i1.2610Revista de artes marciales asiáticas 20261MANEJO DA NEUROPATIA PÓS-IMPLANTE DENTÁRIO: ABORDAGENS TERAPÊUTICAS ATUAIS E PERSPECTIVAS REGENERATIVASA neuropatia pós-implante dentário representa uma complicação neurossensorial relevante da Implantodontia contemporânea, especialmente em procedimentos realizados na região posterior da mandíbula devido à proximidade anatômica com o nervo alveolar inferior. O presente estudo teve como objetivo analisar as principais abordagens terapêuticas atuais utilizadas no manejo da neuropatia pós-implante dentário, bem como discutir as perspectivas regenerativas voltadas à recuperação neural periférica. Trata-se de uma revisão integrativa da literatura, de abordagem qualitativa, descritiva e analítica, fundamentada no modelo metodológico de Whittemore e Knafl. A busca bibliográfica foi realizada nas bases PubMed/MEDLINE, ScienceDirect, Scopus e Web of Science, utilizando descritores relacionados às lesões do nervo alveolar inferior, neuropatia trigeminal pós-traumática, regeneração nervosa periférica e terapias regenerativas associadas à Implantodontia. Foram incluídos artigos científicos publicados entre 2015 e 2025, além de estudos clássicos considerados relevantes para compreensão do tema. Ao final da triagem, 16 estudos compuseram a amostra final da revisão. Os achados demonstraram que as neuropatias pós-implante apresentam etiologia multifatorial, envolvendo trauma mecânico, compressão neural, lesão térmica, hemorragia intraneural e processos inflamatórios locais. Observou-se que o diagnóstico precoce associado ao adequado planejamento tridimensional exerce papel fundamental na prevenção e prognóstico dessas complicações. O manejo conservador baseado em corticosteroides, anticonvulsivantes e acompanhamento neurossensorial permanece como primeira linha terapêutica, enquanto abordagens microcirúrgicas são indicadas nos casos refratários ou associados a lesões severas. Além disso, terapias regenerativas envolvendo PRP, PRF e CGF vêm demonstrando potencial promissor na estimulação da regeneração neural periférica. Conclui-se que o manejo da neuropatia pós-implante dentário deve ser individualizado, multidisciplinar e baseado na gravidade da lesão neural.Marcos Pereira Villa- Nova; Nemer Melo Fraiha; Brunno Pereira Silva; Ricardo Furtado Cortês Bonifácio; Daniel Ortega Oliveira da Silva; Idalisio Soares Aranha Neto; Helamã Coelho Leite; Maiza Silva do Nascimento; Roberto Machado Cruz; Fabiano de Paiva Sales; José Edson Fortunato da Silva; Rebeca Vidal Capelupi; Lucas Vinícius da Silva Milani; Maria Eduarda Alves da Rocha

Afferent; Peripheral neuropathy; Peripheral nervous system; Peripheral nerve; Medicine; Gynecology

2026-05-28https://doi.org/10.51891/rease.v12i5.27120Revista Ibero-Americana de Humanidades, Ciências e Educação 20261Poor sleep quality in basic Medical studentsSome studies have shown that students in the health field have a significant rate of depression and anxiety, with sleep deprivation being one of the possible causes. Thus, the present study aims to evaluate the sleep quality of medical students throughout the different periods of the basic cycle, through the application of the Pittsburgh Sleep Quality Index – Brazilian version. This is an observational, cross-sectional study, in which convenience sampling was used. Students regularly enrolled in the Medicine course at a Brazilian University in 2025, from the first five semesters, were included. The study sample consisted of 90 medical students from a Brazilian University, from the first 5 semesters of their undergraduate studies. No statistically significant differences were observed between the groups (H = 2.23; p = 0.69). The overall mean score of the Pittsburgh Sleep Quality Index was 7.66 ± 2.89 points, indicating a predominance of poor sleep quality in the sample. Among the components of the instrument, the highest mean scores were observed in the domains of daytime dysfunction (1.86 ± 0.85), subjective sleep quality (1.47 ± 0.71), and sleep latency (1.41 ± 0.88). The profile presented suggests that the main sleep problems in the sample are related to behavioral and academic factors; in contrast, more serious clinical problems, such as dependence on sleep medication, do not appear to be frequent. It becomes imperative that higher education institutions develop and implement education programs on sleep hygiene and stress management strategies.Juan Upegui Passos; Pietra Dayrell Drummond Saadi; João Victor Nascimento de Sousa; Lucas Henrique Costa Morais; Ana Paula Machado da Rocha

Pittsburgh Sleep Quality Index; Sleep hygiene; Sleep (system call); Sleep quality; Depression (economics); Sleep onset latency; Sleep medicine; Medicine; Psychology; Clinical psychology; Gerontology; Physical therapy; Sleep deprivation; Sleep debt; Quality (philosophy); Sleep disorder; Sample (material)

2026-05-28https://doi.org/10.33448/rsd-v15i5.51153Research Society and Development 20261Abstracts - Poster PresentationObjectives: To investigate the epidemiological and economic burden of emergency hospitalizations due to migraine and other headache syndromes in the state of Rio de Janeiro between 2021 and 2024.Methods: This was a descriptive and retrospective study using data on hospital morbidity in the population of Rio de Janeiro state, obtained from the Brazilian Unified Health System Hospital Information System (SIH/SUS) via the DATASUS platform, covering the period from 2021 to 2024.Hospital admissions classified as emergency care and related to ICD-10 codes for migraine and other headache syndromes were selected.The variables analyzed included the total number of hospitalizations and the average cost per hospitalization, stratified by Health Region (CIR), age group, and sex.Results: Between 2021 and 2024, a total of 844 emergency hospitalizations related to migraine and other headache syndromes were recorded in the state of Rio de Janeiro.The highest incidence was observed in the 30-39-year age group (19.43%), with a predominance of females (64.22%), consistent with the higher prevalence of these conditions in women of reproductive age.Regarding geographic distribution, the health regions with the highest number of hospitalizations were Médio Paraíba (195 admissions; 23.1%), Metropolitan II (191; 22.6%), and Metropolitan I (163; 19.3%), reflecting greater demand in urban centers and densely populated areas.The regions with the lowest hospitalization numbers were Baía da Ilha Grande (7; 0.8%), Baixada Litorânea (16; 1.9%), and Centro-Sul (35; 4.1%).In 2024, the average cost per hospitalization was R$ 330.53, ranging from R$ 155.57 in Baixada Litorânea to R$ 412.27 in Metropolitan I. Médio Paraíba, which had the highest number of hospitalizations, showed an average cost of R$ 362.83, whereas Baía da Ilha Grande, with the lowest number of hospitalizations, had an average cost of R$ 156.83.These differences likely reflect variations in care complexity and hospital resource availability across regions.Conclusion: Emergency hospitalizations for migraine and other headache syndromes in Rio de Janeiro from 2021 to 2024 were concentrated among women aged 30-39 and in regions with higher population density.Regional differences in hospitalization costs suggest variability in care complexity and resource allocation, highlighting the importance of targeted healthcare planning and resource distribution.Carlas Veras Yigashira de Oliveira; Priscila Freitas Azeredo; Heitor Enéias Cordeiro; José António Vieira da Silva; Daniel Pereira de Melo Camara; Amanda Melo Leite Leão; Marianela Mendoza Rios; Bárbara Araújo Pereira Cabral; Jullia Meireles Alvera; Gabriel Thomaz Candido; Ana Paula Da Silva Wives; João Éder Ribeiro Tuler; Priscila Freitas Azeredo; Isabella Ribeiro da Costa; Giulia Tolentino Brauns; Beatriz Santos Viana da Silva; Amanda Abreu; Nathália Vieira Caires; Fernando Antunes Bastos; Gabrielle Gomes Garcia; MARIA CLARA TAVARES; Jacqueline Fernandes; Beatriz Nascimento Grupilo; Ana Fernandes Rodrigues da Cunha de Almeida; Danilo Caillaux de Almeida; Cláudia Cecília da Silva Rêgo; Ana Beatriz Ribeiro Ferreira; Rafael De Souza Junqueira; Matheus Jorand Cecatto; Léo Freitas Corrêa; Mônica Felippe de Lima; João Machado Tardin; Elisa Hypólito Montovanil; Fábio Condé Evaristo; Julia Fernandes; Danilo Bines; Júlia Candido Godoy; Felipe Tomé do Nascimento; Renan Avelino Mancini; Sarah Fariña Alheiros; Emanuelle de Oliveira Francelino; Karina Nonato Pingituro Domingues; Kelma Macedo Pohlmann Simões; Gabriela Muffarrej Cunha Paixão; VERÔNICA GUIMARÃES IRIAS DE LIMA; Gabriel Alverca Meyas; Carlos Eduardo Do Amaral; Rayane Almeida; Luana Santana da Silva; Mariana Riscado Ramos Gomes; Milena Groetares; Gabriel Paraizo Santos

Metropolitan area; Migraine; Epidemiology; Incidence (geometry); Population; Public health; Health care; Medicine; Emergency medicine; Presentation (obstetrics); Medical emergency; Pediatrics; Demography; Retrospective cohort study; Disease; Environmental health

2026-05-29https://doi.org/10.46979/rbn.v62isuppl.74788Revista brasileira de neurologia 20261Composition of enteral nutrition formulations available for use in Intensive Care Units of Brazilian hospitals: an observational studyIntroduction: Critically ill patients present clinical and metabolic changes, and enteral nutrition therapy is an integral part of treatment, with formulations of diverse compositions available on the market. Objective: To analyze the nutritional composition of closed-system enteral nutrition formulations available for use in Brazilian Intensive Care Units. Methods: This is a cross-sectional, observational, and descriptive study. We performed a composition analysis of labels/portfolios of enteral nutrition in a closed system from the three main brands supplying to Brazil, to obtain data such as the quantity and source of macronutrients, and compliance to international and national recommendations about the quantity of micronutrients. Pearson correlation, ANOVA and Kruskal-Wallis were conducted with SPSS software version 23.0. Results: Forty-two enteral nutrition formulations were analyzed. All samples provided micronutrient levels recommended by Brazilian legislation, except for vitamin D. Maltodextrin was the main carbohydrate source, and glucose syrup was present in five samples. Fiber was present in 57%, with a predominance of soluble fibers. Calcium caseinate was the main protein source, and only 21.4% of the samples had a blend of animal and plant-based proteins. Sunflower and canola oils were the main lipid sources, and 61.9% of the formulations contained fish oil. Conclusion: Enteral nutrition composition can influence gastrointestinal tolerance, immune and inflammatory response, the prevention of malnutrition and ICU-acquired weakness.Jéssica Viana Hinkelmann; Ana Paula Boroni MOREIRA; Júlia D`Almeida Francisquini; Ítalo Tuler Perrone; Rodrigo Stephani; Sheila Cristina Potente Dutra Luquetti

Parenteral nutrition; Enteral administration; Clinical nutrition; Observational study; Malnutrition; Micronutrient; Medicine; Intensive care; Intensive care medicine; Composition (language); Critically ill; Food science; Medical nutrition therapy

2026-05-01https://doaj.org/article/bef149ba9b084de4bb69b67c8853bbbaDOAJ (DOAJ: Directory of Open Access Journals) 20261Impact of bovine neosporosis on reproductive performance of Girolando cows from a closed herd in BrazilDaniela Cristina Rocha de Freitas; M. Da Costa; Nicolas Moreira Piedras Monnerat Caparelli; Thiago Souza Vieira; Samuel Rodrigues Bonamichi do Couto; Líria Hiromi Okuda; Vera Lúcia Teixeira de Jesus; Marco Roberto Bourg de Mello

Neospora caninum; Herd; Serostatus; Ice calving; Seroprevalence; Abortion; Pregnancy rate; Pregnancy; Biology; Animal science; Veterinary medicine; Dairy cattle; Reproduction; Prevalence; Neospora

2026-05-30https://doi.org/10.1016/j.vprsr.2026.101510Veterinary Parasitology Regional Studies and Reports 20261Accuracy evaluation of dual-function scan body for recording complete arch implant-supported prosthesesMatheus Harllen Gonçalves Veríssimo; Rodrigo Falcão Carvalho Porto de Freitas; André Luiz Miranda dos Santos; Guilherme Silva Pires de Sá; Luana Bárbara Rodrigues de França; André Ulisses Dantas Batista; Ana Larisse Carneiro Pereira

Arch; Computed tomography; Prosthesis; Orthodontics; Medicine; Computer science

2026-05-30https://doi.org/10.1016/j.prosdent.2026.05.013Journal of Prosthetic Dentistry 20261A Epistemologia do Professor na Era Da Reprodutibilidade Generativa: Apontamentos Teóricos Sobre Prática Docente, Ensino de Administração e Inteligência ArtificialA vida contemporânea assiste à ascensão da inteligência artificial (IA) enquanto padrão tecnológico, transformando práticas de trabalho e estruturas produtivas. Deste processo, emergem dois fluxos discursivos: um, de viés equilibrado, vê na inteligência artificial generativa (IAG) uma ferramenta de melhoria da produtividade humana; e outro, ancorado em uma perspectiva histórico-social, que antecipa cenários opostos, em que seres humanos perdem capacidade cognitiva e organização política no longo prazo. Mas quais os efeitos destas perspectivas no campo da docência do ensino superior? Especificamente no ensino de administração, para onde as experiências que já habitam a realidade imediata parecem apontar? Este ensaio teórico se propõe a construir reflexões sobre os efeitos da reprodutibilidade generativa e devires humanos artificiais na educação, além de apontamentos e aprofundamento crítico do papel da IAG na atividade da docência na Administração. Para isso, se inspira multidisciplinar e metaforicamente no trabalho de Walter Benjamin, “A obra de Arte na era da sua reprodutibilidade técnica", e recupera o conceito de “epistemologia do professor”, de Fernando Becker, para propor o modelo conceitual “Efeitos de Reprodutibilidade e Deslocamento da IAG na Epistemologia do Professor".Thiago Gomes de Almeida; Camila Braga Soares Pinto

Human life; Work (physics); Philosophy; Humanities; Chemistry

2026-05-31https://doi.org/10.13058/raep.2026.v27n1.2705Administração Ensino e Pesquisa 20261ncevidanes/roots: v1.0.0 - Primeira Versão EstávelThis computer programme consists of a static web application designed to inspect, analyse, and visualise the contents of files in the structured .root format, widely used within the High-Energy Physics community (CERN). Developed using modern web technologies, such as WebAssembly, the tool processes files locally on the client-side, ensuring privacy and high performance without requiring uploads to external servers. The objective is to provide an agile, platform-independent alternative for researchers who need to quickly check histograms, graphs, and data trees (TTrees) without the overhead of configuring the full ROOT framework environment locally. Available for public access and use at: https://ncevidanes.github.io/roots/ Open-source and documented code available in the project's GitHub repository.Nelson Assis

Upload; Code (set theory); Overhead (engineering); Web application; Web page; Key (lock); Privilege (computing); Computer science; World Wide Web; Computer security; Public access; Database

2026-05-31https://github.com/ncevidanes/roots/tree/v1.0.0Open MIND 20261Designing an affordable dip-coating systemFiles used in the development designing an affordable dip-coating system.Vinycios Moreira André; Rodrigo Alves Dias; Moyra Vieira; Ramon Christ Gohering Santos; Guilherme Camanho Costa; Celly Izumi

Key (lock); Work (physics); Systems design; Information system; Computer science; Business; Systems engineering

2026-05-31https://doi.org/10.5281/zenodo.20478254Zenodo (CERN European Organization for Nuclear Research) 20261PROPOSTA TÉCNICA DE APLICAÇÃO DA TOXINA BOTULÍNICA TIPO A NA MUSCULATURA FRONTAL BASEADA NA INTERSECÇÃO CONTROLADA DE HALOS DE DIFUSÃO: RACIONAL TEÓRICO-OPERACIONALA toxina botulínica tipo A (TBXA) é amplamente utilizada na prática odontológica para fins estéticos e terapêuticos, seguindo protocolos tradicionais baseados na distribuição equidistante dos pontos de aplicação, com o objetivo de evitar a sobreposição dos halos de difusão. No entanto, a limitada durabilidade dos efeitos e a variabilidade de resposta clínica sugerem a necessidade de uma análise crítica das abordagens vigentes. O presente manuscrito propõe e descreve uma técnica teórico-operacional de aplicação da TBXA fundamentada na intersecção controlada dos halos de ação, obtida por meio da redução do espaçamento entre os pontos de injeção. Hipoteticamente, essa estratégia poderia favorecer uma distribuição mais homogênea da toxina no músculo frontal, potencializando o recrutamento de fibras musculares profundas e contribuindo para a uniformidade do relaxamento muscular, sem aumento da dose total administrada. A proposta é apresentada como hipótese técnica, detalhando aspectos de demarcação, dosagem, profundidade de aplicação, precauções anatômicas e critérios provisórios de seleção de pacientes. Discussões sobre anatomia funcional, segurança, limitações e perspectivas de validação experimental são incluídas.Thiago Borges Mattos; Lídia Batista Conrado Martins; João Marcos Mattos; Érica Leonel Sobral de Souza; Paula Karoline; Karina Cazzeta Sales Neves; Luiz Meireles Mayrink; Caio Salles

Halo; Concentric; Electrodiagnosis; Flexor muscles; Physics; Medicine

2026-06-01https://doi.org/10.66104/7fsv4r76Revista Multidisciplinar do Nordeste Mineiro 20261Model development and efficient calibration of railway transition zones using experimental dataAbstract The mechanical behavior of the train–track system plays a pivotal role in defining relevant operational parameters, such as train speed, comfort, and safety. In sections where the railway subgrade is well compacted, train circulation is smoother and more stable, with lower levels of displacement during operation. However, railway transition zones between embankments and viaducts often show significant stiffness changes, which can lead to differential settlements, larger deflections, and higher maintenance needs over time. This study develops and experimentally calibrates a finite-element computational model to simulate the mechanical response of such transition zones. The model is calibrated using track deflection measurements obtained at only three instrumented locations under trains operating at multiple speeds on an active Brazilian railway. Numerical–experimental comparisons identify the governing parameters affecting track response within the transition region. In addition, a spatial stiffness-variation function is formulated and its parameters are calibrated using the same measurement set. The results allow a more accurate representation of train–track interaction and provide guidance for the design and maintenance of durable, safer railway transition zones.Ricardo Vidal; Alexandre Cury; Flávio Barbosa

Track (disk drive); Calibration; Train; Subgrade; Deflection (physics); Stiffness; Experimental data; Displacement (psychology); Engineering; Structural engineering; Differential (mechanical device); Representation (politics); Mathematical model; Function (biology); Offset (computer science); Penalty method; Continuation; Unobservable

2026-06-01https://doi.org/10.1007/s40534-026-00440-9Railway Engineering Science 20261HOTFy: randomised clinical trial for hyperbaric oxygen therapy in fibromyalgiaBACKGROUND: Fibromyalgia is a polysymptomatic central sensitisation disorder characterised by widespread pain, fatigue, sleep disturbances and neuropsychiatric features. Hyperbaric oxygen therapy modulates neuroinflammation, mitochondrial function and neuroplasticity, thereby yielding analgesic and functional benefits. OBJECTIVE: Evaluate the efficacy and optimal timing of hyperbaric oxygen therapy as an adjunct to standard care for fibromyalgia. DESIGN, SETTING AND PARTICIPANTS: This single-centre, randomised, cross-over group, assessor-blinded clinical trial was conducted in the Department of Rheumatology at the University Hospital of the Federal University of Juiz de Fora, Juiz de Fora, Brazil, and adhered to Consolidated Standards of Reporting Trials (CONSORT) guidelines. Women (18-70 years) with a diagnosis of fibromyalgia for ≥2 years were randomised 1:1 to early hyperbaric oxygen therapy plus standard care or standard care alone (delayed group). Intention-to-treat (ITT) analysis was conducted with all 56 participants (mean age: 51.0±9.8 years; mean body mass index: 30.5±5.1 kg/m²). INTERVENTIONS: Standardised care (education, exercise and pharmacotherapy) plus hyperbaric oxygen therapy was delivered at 2.3 atmospheres absolute for 90 min, five times per week, over 8 weeks (total 32-40 sessions). The early group received hyperbaric oxygen therapy during weeks 0-8, while the delayed group received it during weeks 8-16, following the same protocol. OUTCOMES: Primary endpoints included the Fibromyalgia Impact Questionnaire-Brazilian Portuguese (FIQR-Br), the pain visual analogue scale (VAS) and the Symptoms Assessment Scale-40 (EAS-40) for psychopathology. Secondary endpoints included the 12-Item Short-Form Health Survey (SF-12) physical and mental components and adverse effects. Assessments were conducted at baseline, 8 weeks and 16 weeks, and analysed using a mixed-design 2×3 analysis of variance (group: early vs delayed; time: baseline, 8 weeks and 16 weeks) with Greenhouse-Geisser corrections as needed, followed by Bonferroni post hoc tests. Missing data were assessed using Little's missing completely at random (MCAR), and considering the ITT analysis, the means imputed for missing data were estimated through expectation maximisation. Effect sizes were reported as partial η² and Cohen's d with α=0.05. RESULTS: 44 participants completed the study, and the overall withdrawal rate was 21.4% with no baseline between-group differences. Significant time effects were observed for all primary outcomes and the SF-12 outcome (p<0.001; η²=0.23-0.60). Group×time interactions were significant for FIQR-Br, VAS, EAS-40 and SF-12 physical and mental (p≤0.02; interaction η² up to 0.23), indicating improvements during active hyperbaric oxygen therapy exposure. Compared with standard care alone over 8 weeks, combined treatment achieved greater gains: FIQR-Br, -31.1% vs -14.4%; VAS, -54.0% vs -33.5%; EAS-40, -28.4% vs -3.7%; SF-12 physical, +39.1% vs +14.8%; SF-12 mental, +57.4% vs +31.9%. Large within-group effect sizes were observed (eg, VAS d=2.5-2.7; FIQR-Br d=1.4-1.7). Efficacy was equivalent regardless of time started, and the benefits converged by the end of each hyperbaric oxygen therapy phase. After stopping hyperbaric oxygen therapy, the FIQR-Br and SF-12 mental component scores regressed towards standard care levels, whereas residual improvements persisted for up to 8 weeks in VAS, EAS-40 and SF-12 physical component scores. Adverse events were infrequent; one case of otalgia required extended management. Withdrawals were primarily due to non-compliance or intolerance to chamber confinement. No serious or unexpected safety concerns were reported. CONCLUSIONS: Hyperbaric oxygen therapy, delivered under a standardised protocol, is an effective and well-tolerated adjunct to multimodal fibromyalgia care. Timing can be individualised: early initiation for rapid relief or stepped introduction after optimised usual care, with comparable overall efficacy. The durability of the benefit appears to be exposure dependent, and maintenance or booster schedules merit further evaluation. TRIAL REGISTRATION NUMBER: RBR-6prps8g.José da Mota Neto; Adriano Fernando [UNIFESP] Mendes Junior; Anita Fernanda Magalhães Martins; Aline Teixeira de Landa; Rafael Cavanellas Fraga; Viviane Angelina de Souza; Nádia Rezende Barbosa Raposo

Fibromyalgia; Clinical trial; Adverse effect; Randomized controlled trial; Visual analogue scale; Clinical endpoint; Hyperbaric oxygen; Medicine; Physical therapy; Ozone therapy; Psychological intervention; Oxygen therapy

2026-06-01https://doi.org/10.1136/bmjopen-2025-112284BMJ Open 20261Snake functional traits are more influenced by microhabitat than by environmental gradients in the Upper Paraguay River BasinUnderstanding the mechanisms that shape species distributions and community structure is essential for biodiversity conservation. In this study, we investigate the functional diversity of snake species in the Upper Paraguay River Basin (UPRB), addressing four key questions: (1) Do environmental characteristics of the UPRB influence snake species distribution? (2) Do snake functional traits explain species’ occurrence in specific communities? (3) How do environmental characteristics influence aspects of functional diversity? and (4) How are snake traits related to microhabitat use? We analyzed occurrence and trait data for 145 snake species using multivariate approaches to assess the contributions of environmental variables and functional traits. Our results demonstrate that environmental variables significantly shape species distributions across the UPRB. In contrast, functional traits alone did not predict community composition at broader spatial scales (habitat). However, functional diversity indices responded to environmental gradients, indicating that certain aspects of trait composition vary with local habitat conditions. Additionally, traits were strongly associated with microhabitat preferences, revealing fine-scale trait–environment relationships. These findings highlight the complexity of community assembly in Neotropical snake assemblages and the value of integrating environmental gradients, functional diversity metrics, and trait-microhabitat linkages into conservation strategies.Vanessa Nocelli; Liliana Piatti; Diego José Santana; Simone J. Cardoso; Henrique C. Costa

Drainage basin; Nestedness; Biodiversity; Habitat; Species diversity; Functional diversity; Ecology; Geography; Environmental science

2026-06-01https://doi.org/10.1080/01650521.2026.2665825Studies on Neotropical Fauna and Environment 20261Social wasps preferentially nest on exotic plants: a field-based comparative surveyThe reproductive success of social wasps is closely linked to their choice of nesting substrates, which can include natural plant structures or human-made elements. In environments altered by human activity, exotic plant species often become dominant and may be selected by wasps as nesting sites. In this study, we evaluated whether plant morphological traits and arthropod abundance influence the nesting preference of social wasps on native and exotic plants. Although exotic plants hosted a greater number of colonies and species, traditional morphological traits previously considered important for nest site selection were not significant predictors. Our results suggest that other ecological factors such as reduced herbivory and a lower abundance of natural enemies on exotic plants may create safer conditions that facilitate colony establishment. These findings support the hypothesis that changes in trophic structure associated with biological invasions can benefit social insects by decreasing predation pressure and competition.Bruno Corrêa Barbosa; Tatiane Tagliatti Maciel; José Cola Zanuncio; Fábio Prezoto

Nest (protein structural motif); Hymenoptera; Introduced species; Nest box; Entomology; Ecology; Biology; Geography; Zoology

2026-06-01https://doi.org/10.1080/01650521.2026.2677656Studies on Neotropical Fauna and Environment 20261O macro e o micro na história digital: uma reflexão sobre a prática de pesquisa a partir dos arquivos latino-americanos da pandemiaO artigo busca compreender as características de arquivos digitais criados para documentar a pandemia de COVID-19 na América Latina a partir de meados de 2020 – enfocando aspectos como as trajetórias de seus criadores e as estratégias de documentação empregadas. A partir disso, propõe-se uma reflexão teórico-metodológica acerca da prática de pesquisa em história em meio à transformação digital. Buscando uma “hermenêutica da prática”, reflete-se sobre as implicações, as tensões e os diálogos entre as estratégias de pesquisa empregadas, quais sejam, métodos de classificação e comparação, com auxílio de ferramentas computacionais (em uma perspectiva macro), e uma combinação de entrevistas de história oral e etnografia digital (em uma perspectiva micro). O artigo, portanto, discute a prática da história digital, contribuindo para os debates acerca do uso de bases de dados, história oral e etnografia na pesquisa em história.Ian Kisil Marino

Ethnography; Context (archaeology); Perspective (graphical); Political science; Humanities; Sociology

2026-04-09https://doi.org/10.11606/issn.2316-9141.rh.2026.231357Revista de História 20261ncevidanes/roots: v1.0.1 - Informações e ajustes atualizadosAtualização na documentação do projeto, inclusão de metadados técnicos e ajustes na interface do usuário.Nelson Assis

Interface (matter); Context (archaeology); Work (physics); Limiting

2026-06-02https://github.com/ncevidanes/roots/tree/v1.0.1Open MIND 20261Integrando análise química e o saber popular: Tem cafeína no xampu bomba de café?Este estudo investiga a extração de cafeína pela adição de pó de café em xampu neutro, prática conhecida como “xampu bomba”. Popular nas redes sociais, essa tendência caseira oferece uma oportunidade singular de conectar a cultura popular à investigação científica no ensino de Química. Buscou-se quantificar o teor de cafeína extraído ao longo do tempo e avaliar a influência dos componentes do xampu, como tensoativos e sais, na eficiência do processo de extração. As amostras foram preparadas com café moído e xampu neutro, sendo analisadas ao longo de dois meses por meio de espectrofotometria UV-Vis. Os resultados revelaram que a concentração máxima de cafeína ocorre após sete dias, atingindo um valor superior ao encontrado em produtos comerciais. Além da relevância analítica, o estudo pode ser aplicado em sala de aula, envolvendo os estudantes em um planejamento experimental ancorado em um contexto do cotidiano.Danielle Tomaz Oliveira; Thiago dos Santos Almeida; Ingrid Nunes Derossi

Context (archaeology); Data collection; Field (mathematics); Process (computing); Computer science; Physics

2026-05-27https://doi.org/10.47734/iluminart.v25.01.p-07Revista Iluminart 20261Study of the synergistic effect of sodium citrate and phosphates on the colloidal stability of skim milk under controlled severe heat treatment conditionsBackground Colloidal stability is crucial for milk processing at very high temperatures. Intense heat unbalances mineral and protein equilibrium, often leading to coagulation, sedimentation and quality loss. Chelating salts, such as sodium citrate and sodium phosphates, are frequently used to control ionic calcium concentration and enhance thermal stability. However, data on the combined effects of multiple salts on milk stability under severe heat treatments are still scarce. Aim This research aimed to identify optimal salt combinations to improve the stability of skim milk under high‐temperature conditions. To achieve this, the interaction between different salts was analysed to determine their impact on colloidal and thermal properties. Methods A four‐component simplex‐centroid mixture design was used to formulate skim milk from commercial milk powder with varying concentrations of chelating salts. Samples were subjected to a simulated treatment at 155°C and analysed using mixture regression models and analysis of variance (ANOVA), followed by multi‐response optimisation and response surface analysis. Major Findings Both before and after heat treatment, sodium triphosphate was the most effective salt for reducing ionic calcium levels. Conversely, sodium monophosphate proved most effective for prolonging thermal stability. The results demonstrated that the salts exhibited synergistic effects when combined, showing a clear synergy that balanced pH, free calcium and heat coagulation time. Scientific or Industrial Implications The observed synergy between salts is fundamental for maintaining the mineral and protein balance. The optimal formulation was found to be a mixture of 46.5% sodium citrate, 37.6% sodium monophosphate and 16.0% sodium triphosphate. Validation tests showed that experimental results were closely aligned with predicted values, with relative errors of less than 5%, confirming the robustness of the optimisation model.Thaís Lourenço Oliveira; Nathalia da Silva Campos; Camille Machado Pimentel; Eduarda Coelho Gaugard Desiderio; Rodrigo Stephani; Luiz Fernando Cappa de Oliveira

Sodium citrate; Sodium; Skimmed milk; Colloid; Calcium; Thermal stability; Salt (chemistry); Chelation; Heat stability; Chemistry; Coagulation; Chromatography; Ionic strength; Sodium Caseinate; Ionic bonding; Sodium nitrate

2026-04-01https://doi.org/10.1111/1471-0307.70137International Journal of Dairy Technology 20261Da LDB à BNCCEste estudo investiga como a Lei de Diretrizes e Bases da Educação Nacional e a Base Nacional Comum Curricular orientam a prática avaliativa na Educação Básica, destacando como a avaliação da aprendizagem é abordada nas diferentes versões dos dois documentos. A pesquisa documental, interpretada pela Análise de Conteúdo, revelou a transição da cultura centrada em exames para propostas mais formativas, embora persistam lacunas conceituais e desafios na/para a formação docente. Apesar do reconhecimento de diferentes instrumentos avaliativos, não são definidos termos como avaliação formativa e aspectos qualitativos/quantitativos. Dessa forma, conhecer como a avaliação vem sendo concebida permite refletir sobre as práticas atuais e, assim, propor formas que beneficiem a aprendizagem.Isabela Vieira da Silva; Andréia Francisco Afonso

Base (topology); Humanities; Philosophy

2026-06-03https://doi.org/10.24933/horizontes.v44i1.2239Horizontes 20261Conditions leading to exceptionally high temperatures in shallow tropical lakesAbstract Factors leading to exceptionally high temperatures in shallow tropical waters are examined with high‐resolution measurements and application of a 3‐dimensional hydrodynamic model in an Amazon floodplain lake. Highest near‐surface (0.05 m) temperatures in open water ranged from 31.0 to 37.5°C. Within mats of floating plants maximum temperatures ranged from 33.7 to 39.8°C, and within flooded forests from 30.6 to 34.1°C. Highest open water temperatures occurred when water was shallow (ca. 1 m), underwater attenuation was high (5.5–7.5 m −1 ), skies were clear (solar radiation ca. 1000 W m −2 ), winds were low (≤ 1 to 2–3 m s −1 ), and air temperatures were in the mid‐30°C range. Heat budgets indicate that latent heat fluxes ranged from ~ −100 W m −2 under light winds to −200 to −250 W m −2 with 4 m s −1 winds. Sensible heat flux was usually negative, as lake temperatures exceeded air temperatures, and much less than latent heat flux. Hydrodynamic simulations quantified how interactions among drivers lead to exceptional warming: reduced wind speeds (≤ 30% of reference) increased near‐surface temperature by 3–4°C, while elevated air temperatures (up to 37.5°C) and high turbidity contributed an additional 1–2°C. The simulations indicate that exceptional water temperatures (up to 42°C) can occur when a shallow, turbid lake under clear skies with high air temperatures and low wind speeds simultaneously maximize heat gain and minimize heat loss. Projections of climatic changes are likely to increase incidences of exceptional water temperatures.Wencai Zhou; John M. Melack; Sally MacIntyre; João H. F. Amaral; Pedro M. Barbosa

Latent heat; Turbidity; Sensible heat; Wind speed; Air temperature; Heat flux; Water vapor; Open water; Environmental science; Atmospheric sciences; Waves and shallow water; Flux (metallurgy); Cloud cover; Hydrology (agriculture); Climatology; Floodplain

2026-06-01https://doi.org/10.1002/lno.70415Limnology and Oceanography 20261DT-CREATE Replication Package: A Service Suite for Self-Adaptive Digital Twins Supporting Predictive Maintenance Decisions in Industry 5.0Replication package for the paper "DT-CREATE: A Service Suite for Self-Adaptive Digital Twins Supporting Predictive Maintenance Decisions in Industry 5.0", focused on decision support for predictive maintenance. Contains five datasets (textile industry, heat-treatment furnace, NASA C-MAPSS FD001, and de-identified industry machine logs), Python scripts reproducing all classification experiments (ADAPTflow/PyCaret, single-algorithm baselines, framework-level baselines, and ontology/SWRL ablation analysis), two Jupyter notebooks from the exploratory workflow, and JSON result files with per-seed metrics reported in the paper. The raw industry export (~613 MB, confidential) is not redistributed; all included files are sufficient to reproduce the reported results.Izaque Esteves da Silva; Regina Braga; José Maria Nazar David; Victor Ströele

Suite; JSON; Python (programming language); Replication (statistics); Scripting language; Decision support system; Workflow; Service (business); Computer science; Software engineering; Database; Automation; Predictive maintenance; Upgrade; Web service; The Internet; Software

2026-05-28https://doi.org/10.5281/zenodo.20419147Zenodo (CERN European Organization for Nuclear Research) 20261TECNOLOGIA E SOCIEDADE: PARA UMA ABORDAGEM CRÍTICA E DEMOCRÁTICAEste capítulo discute as principais abordagens filosóficas da tecnologia e apresenta a teoria crítica da tecnologia de Andrew Feenberg. Trata-se de um estudo que aborda os fundamentos do instrumentalismo, determinismo e substantivismo, bem como as influências que contribuíram para a formulação da teoria crítica da tecnologia. Sustenta-se que tecnologias podem ser compreendidas como neutras, inevitáveis, fiéis às regras da eficiência, autônomas e capazes de incorporar valores substanciais. A teoria crítica da tecnologia acrescenta que elas podem ser consideradas resultado do conhecimento técnico dos especialistas envolvidos no projeto tecnológico somado às experiências dos seus usuários. A concepção democrática da tecnologia emerge dessa compreensão, como um caminho para que usuários possam influenciar o projeto tecnológico, de forma a representar interesses diversos e contextos distintos.Luciana De Lima Dusi

Perspective (graphical); Face (sociological concept); Context (archaeology); Scope (computer science); Field (mathematics); Philosophy; Sociology

2026-01-01https://doi.org/10.37885/260221304Editora Científica Digital eBooks 20261Safety and Feasibility of Low-Intensity Transcranial Focused Ultrasound Targeting the Anterior ThalamusLow-intensity transcranial focused ultrasound (tFUS) is a novel noninvasive neuromodulation technique capable of reaching deep brain structures with high spatial precision. The anterior thalamus, a key relay in pain processing, is a promising target for modulating central pain networks. In this context, this study aims to assess the safety, feasibility, and preliminary effects of anterior thalamic low-intensity tFUS in patients with chronic Central Neuropathic Pain (CNP). In this prospective, open-label, single-arm pilot study, 5 adults with refractory central neuropathic pain underwent neuronavigated low-intensity transcranial focused ultrasound targeting the anterior thalamus contralateral to the pain-affected region. Each session consisted of two 10-minute stimulation blocks separated by 20 minutes. Pain intensity was assessed using the visual analog scale at baseline, immediately poststimulation, and also after 4 hours, 24 hours and 10 days after the intervention. Secondary outcomes included the Brief Pain Inventory, McGill Pain Questionnaire, Douleur Neuropatique 4, Hamilton Depression Rating Scale, Hamilton Anxiety Rating Scale, Patient Global Impression of Change and Clinical Global Impression of Change scale. The procedure demonstrated feasible with no serious adverse events. One participant experienced mild transient neck discomfort. No statistically significant improvements were observed in pain intensity or secondary outcomes at any time point compared with baseline. Overall, anterior thalamic low-intensity tFUS presented safe and feasible for patients with CNP but did not yield significant short-term analgesic effects. These findings support further controlled clinical trials with larger samples, optimized stimulation parameters and repeated sessions to better evaluate the therapeutic potential of low-intensity tFUS for chronic CNP.Glaucia Aline Nunes; Josimar Reis Ortiz; Claudia Mingrone; Débora Arnaut; Hélder Picarelli; Ricardo Iglésio; Ricardo de Carvalho Nogueira; Juliana da Silva Simões; Pedro Nascimento Martins; Jose Renato Felix Bauab; Renata Montes Garcia Barbosa; Gabriel Taricani Kubota; R CURY; Manoel Jacobsen Teixeira; Marco Antônio Marcolin

Neuromodulation; Thalamus; Neuropathic pain; McGill Pain Questionnaire; Deep brain stimulation; Anxiety; Clinical trial; Phantom limb; Chronic pain; Adverse effect; Medicine; Anesthesia; Physical medicine and rehabilitation; Analgesic; Transcranial direct-current stimulation; Brain stimulation; Nociception; Neuralgia; Depression (economics)

2026-06-03https://doi.org/10.1097/yct.0000000000001298Journal of Ect 20261DT-CREATE Replication Package: A Service Suite for Self-Adaptive Digital Twins Supporting Predictive Maintenance Decisions in Industry 5.0Replication package for the paper "DT-CREATE: A Service Suite for Self-Adaptive Digital Twins Supporting Predictive Maintenance Decisions in Industry 5.0", focused on decision support for predictive maintenance. Contains five datasets (textile industry, heat-treatment furnace, NASA C-MAPSS FD001, and de-identified industry machine logs), Python scripts reproducing all classification experiments (ADAPTflow/PyCaret, single-algorithm baselines, framework-level baselines, and ontology/SWRL ablation analysis), two Jupyter notebooks from the exploratory workflow, and JSON result files with per-seed metrics reported in the paper. The raw industry export (~613 MB, confidential) is not redistributed; all included files are sufficient to reproduce the reported results.Izaque Esteves da Silva; Regina Braga; José Maria Nazar David; Victor Ströele

2026-05-28https://doi.org/10.5281/zenodo.20419148Zenodo (CERN European Organization for Nuclear Research) 20261Gênero, território e violência: uma leitura interseccional da experiência das mulheres rurais moçambicanas em Ventos do apocalipse, de Paulina ChizianeEsta pesquisa tem como objetivo central analisar a complexa relação entre gênero, território e violência a partir de uma perspectiva interseccional, tomando como objeto de estudo o romance Ventos do apocalipse, da escritora moçambicana Paulina Chiziane. A partir da análise crítica da referida obra, exploramos diversas situações de violência verbal, psicológica e física vividas pelas mulheres moçambicanas em territórios devastados pela guerra e dominados pela lógica patriarcal. Fazem parte das principais teóricas para discutir as noções de interseccionalidade e colonialidade do poder, Butler (2021); hooks (2018); Collins e Bilge (2021) e Lugones (2017). O romance de Chiziane se configura como ferramenta fundamental para a crítica feminista, revelando as violências que ocorrem no entrelaçamento de diferentes sistemas de poder.Amosse Jorge Gelo

Romance; Object (grammar); Reading (process); Field (mathematics); Order (exchange); Sociology; Humanities; Gender studies

2026-05-27https://doi.org/10.12957/palimpsesto.2026.94465Palimpsesto 20261Nanostructured Lipid Carriers Enable In Vivo Efficacy of Parthenolide in Schistosoma mansoni InfectionBackground: Schistosomiasis remains a major neglected tropical disease, with praziquantel (PZQ) as the only widely used treatment, despite its limitations. Parthenolide (PTL), a sesquiterpene lactone, exhibits potent in vitro antischistosomal activity; however, its poor aqueous solubility, low oral bioavailability, and chemical instability may limit its in vivo efficacy. Objective: This study investigated whether nanoencapsulation in nanostructured lipid carriers (NLC) could enable the in vivo antischistosomal activity of PTL. Methods: PTL was isolated from Tanacetum parthenium and incorporated into NLC using hot emulsification followed by ultrasonication. The resulting formulation (NLC-PTL) was physicochemically characterized, and its in vivo antischistosomal efficacy was evaluated in a murine model of Schistosoma mansoni infection. Results: NLC-PTL exhibited nanoscale size, low polydispersity, high encapsulation efficiency, and sustained drug release. In vivo, free PTL showed no significant effect on worm burden, whereas NLC-PTL achieved a marked reduction (77.9%) in adult worms and significantly decreased egg output compared to controls (p < 0.001). Blank NLC had no antiparasitic effect. Conclusions: Nanoencapsulation was associated with in vivo antischistosomal activity of PTL compared to the free compound. These findings suggest that formulation strategies may influence the in vivo performance of lipophilic natural products in schistosomiasis.José Marcio Fernandes da Silva; Dominique Mesquita e Silva; Danilo de Souza Costa; Monique C. Amaro; Rayssa A. Cajas; Josué de Moraes; Guilherme Diniz Tavares; Ademar Alves da Silva Filho

In vivo; Praziquantel; Schistosoma mansoni; Parthenolide; In vitro; Schistosomiasis; Drug; Pharmacology; Chemistry; Schistosoma japonicum; Schistosoma; Antiparasitic agent; Oral administration; Bioavailability; Drug delivery

2026-06-03https://doi.org/10.3390/pharmaceutics18060694Pharmaceutics 20261Time spent at or near VO₂max during high-intensity interval training - a systematic review and meta-analysisBACKGROUND: max) has emerged as a key marker of the adaptive potential of HIIT, yet HIIT configurations that maximise tV̇O₂max remain unclear. OBJECTIVE: This systematic review and meta-analysis examined acute tV̇O₂max responses across various HIIT protocols, aiming to identify configurations with the greatest potential to stimulate training adaptations. METHODS: PubMed and Scopus were systematically searched to September 2025 for studies reporting tV̇O₂max during HIIT, defined as time spent at or above ≥ 80% V̇O₂max. Associations between protocol characteristics and tV̇O₂max were evaluated using ANCOVAs and linear mixed-effects models, while random-effects meta-analyses compared standardised mean differences (SMDs) across HIIT configurations, recovery modalities (active vs passive), and exercise intensity distributions in work intervals. RESULTS: max was determined for a total of 239 HIIT protocols. Protocols with long work intervals (≥ 2 min) elicited significantly greater tV̇O₂max than short (≤ 30 s) or moderate (> 30 s to < 2 min) work intervals, and linear mixed-effects models confirmed a positive relationship between cumulative HIIT duration and time ≥ 90% and ≥ 95% V̇O₂max when longer work intervals were used. Protocols incorporating variable-intensity work intervals further increased tV̇O₂max compared to even-paced formats (SMD = 0.80, p < .01). In contrast, recovery modality (active vs passive) showed no effect on tV̇O₂max. CONCLUSIONS: tV̇O₂max exhibits considerable variability, and its dose-response relationship with long-term adaptations requires further investigation. Nevertheless, HIIT protocols with longer and variable-intensity work intervals maximise tV̇O₂max, providing researchers, practitioners, and athletes with a firmer foundation for understanding how specific protocols shape the physiological demands and adaptive potential of a workout.Patrick Schoenmakers; Kelly Murray; Jamie White; Guilherme Matta; Arthur Henrique Bossi

Cardiorespiratory fitness; High-intensity interval training; Interval training; VO2 max; Confidence interval; Modalities; Scopus; Protocol (science); Work (physics); Medicine; Physical therapy; Physical medicine and rehabilitation; Duration (music); Endurance training; Modality (human–computer interaction); Interval (graph theory); Physical fitness; Work rate

2026-06-03https://doi.org/10.1186/s13102-026-01766-xBMC Sports Science Medicine and Rehabilitation 20261Validation of the modified transplant symptom occurrence and symptom distress scale and exploring symptom burden in Brazilian kidney transplant recipientsKidney transplant recipients (KTR) may experience burdensome symptoms, including tremor, nausea, and bruises, sometimes caused by immunosuppressive medication, which can negatively influence health-related quality of life. The 59-item Revised Modified Transplant Symptom Occurrence and Symptom Distress scale (MTSOSD-59R) captures patients' symptom experience but has not been validated in Brazil. We evaluated the Brazilian Portuguese MTSOSD-59R regarding content validity (expert panel), internal structure (factor analysis), and associations with other variables (known-groups approach). Symptom occurrence and distress by sex and age were assessed using ridit analyses. 485 KTR (42.2% women; 50.2 ± 12.8 years) were included at median 7.4 [3.2-13.0] years post-transplantation. The expert-rated scale-content validity index was 0.49. Construct validity and known-group associations were confirmed. The most occurring symptoms were anxiety [ridit score: 0.697], tiredness [0.653], and difficulty seeing well [0.652]. The most distressing symptoms were menstrual problems [0.635], difficulty seeing well [0.606], and genital warts [0.595]. Female/younger KTR tended to report more (distress from) psychological/aesthetic symptoms; male/older KTR tended to report more (distress from) physical symptoms. The MTSOSD-59R showed validity for internal structure and relationships to other variables, but insufficient expert-rated content validity for immunosuppression-specific side effects, suggesting it may better reflect general symptom burden in this population.Niels L. Riemersma; Tim J. Knobbe; Renata M. C. Guedes; J. Ferreira; Luciana A. Cabanelas; Kris Denhaerynck; Sabina de Geest; Helady Sanders‐Pinheiro; J. M. Pestana; Renato D. Foresto; Stephan J. L. Bakker; Lúcio R. Requião-Moura

Kidney transplant; Kidney transplantation; Scale (ratio); Distress; MEDLINE; Psychological distress; Transplantation; Medicine; Intensive care medicine; Internal medicine; Severity of illness; Renal transplant; Kidney disease

2026-06-05https://doi.org/10.1038/s41598-026-56130-3Scientific Reports 20261TECNOLOGIAS DIGITAIS, INCLUSÃO E FORMAÇÃO DOCENTE NA EDUCAÇÃO FÍSICA: UMA REVISÃO DA LITERATURAA formação docente em Educação Física tem sido impactada pelas transformações promovidas pelas tecnologias digitais, exigindo novas competências relacionadas ao ensino, à inclusão e à mediação pedagógica no ensino superior. Nesse contexto, a presente pesquisa teve como objeto de estudo a relação entre educação, tecnologias digitais e formação de professores de Educação Física, sendo orientada pela seguinte questão: de que maneira as novas tecnologias influenciam a formação docente nessa área e quais desafios emergem desse processo? O objetivo consistiu em compreender como os recursos tecnológicos vêm contribuindo para a preparação dos futuros professores, considerando aspectos pedagógicos, digitais e inclusivos. O referencial teórico foi fundamentado em estudos sobre formação docente, competências digitais, inclusão educacional, tecnologia assistiva e Desenho Universal para a Aprendizagem, articulados às diretrizes educacionais brasileiras e internacionais voltadas à educação digital. A pesquisa adotou a revisão integrativa da literatura como procedimento metodológico, com abordagem qualitativa, natureza descritiva e caráter exploratório, realizada por meio da análise de artigos científicos, livros e documentos institucionais publicados sobre a temática. Os resultados evidenciaram que as tecnologias digitais ampliam possibilidades de ensino, aprendizagem e participação, favorecendo práticas pedagógicas mais flexíveis e acessíveis. Também foi identificado que a efetividade desses recursos depende de processos formativos capazes de integrar conhecimentos pedagógicos, competências digitais e estratégias voltadas à diversidade dos estudantes. Conclui-se que a formação docente em Educação Física demanda uma articulação consistente entre inovação tecnológica, inclusão educacional e desenvolvimento profissional, contribuindo para a qualificação da prática pedagógica e para o fortalecimento de processos formativos alinhados às exigências atuais do ensino superior.Márcio Rubens de Paula Medeiros; Bruno Gomes de Souza; ALLISON NOGUEIRA DIÓGENES; Priscila Soares da Silva (24097935); Edinéia de Arruda Américo; Franklin Vieira Soares

Emerging technologies; Massive open online course; Perspective (graphical); Diversity (politics); Humanities; Philosophy; Political science

2026-06-04https://doi.org/10.66104/4nyx3549Revista Saúde dos Vales 20261Discursos na Harmonização EstéticaEste artigo examinou os enunciados a respeito da harmonização estética, indagando a tensão entre a autenticidade e os padrões sociais de beleza. Por meio da Análise do Discurso, com base em Bakhtin, Foucault e Orlandi, investigou-se como a estética normatiza e controla identidades. A análise de enunciados em websites e redes sociais revelou a relação complexa entre liberdade e imposições sociais. O estudo destacou a interação dialógica e a construção da identidade estética em um contexto de medicalização e influência digital. Os resultados mostraram que a harmonização estética, apesar de promover bem-estar, perpetua ideais de beleza e desigualdades. A pesquisa contribuiu para a reflexão crítica sobre a estética contemporânea e sua interação constante entre os discursos sociais e a subjetividade.Walteir Alves Magalhães; Pedro Henrique da SIlva Neves; Erly G. Azevedo

Identity (music); Context (archaeology); Order (exchange); Discourse analysis; Social representation; Ethnography; Subject (documents); Sociology; Humanities; Epistemology

2026-02-28https://doi.org/10.67204/riel.v4i8.2950Revista Interdisciplinar em Estudos de Linguagem 20261Valorization of Industrial Surplus: Development, Production and Characterization of an Ice Cream Formulation Based on Avocado (Persea americana) Pulp and Egg AlbuminNancy Milena Castellanos Sanabria; Jhon Ortiz-Duque; Edwin Arcila; Johan Franco-Mejia; Fabiano Costa; Marcone Augusto Leal de Oliveira; Oscar Vega-Castro

Ice cream; Pulp (tooth); Raw material; Oleic acid; Egg white; Response surface methodology; Food science; Chemistry; Pulp and paper industry; Rheology; Sensory analysis; Fatty acid

2026-01-01https://doi.org/10.2139/ssrn.6878439SSRN Electronic Journal 20261Intersectional Inequities in Treatment Pathways for Peripheral Arterial Disease in Brazil: A Nationwide MAIHDA Analysis of Angioplasty vs AmputationCynthia Florêncio de Mesquita; Ana Maria Bicudo Diniz; Gabriele Eckerdt Lech; Paulo Henrique Moreira Melo; Maria Antônia Costa Cruz Akabane; Lauren Kratky; David P. Mooney

Amputation; Arterial disease; Angioplasty; Peripheral; Vascular disease; Medicine; Surgery; Disease; MEDLINE

2026-06-04https://doi.org/10.1016/j.jvs.2026.03.548Journal of Vascular Surgery 20261Multimodal Intervention to Improve Operating Room Surface Cleaning: A Quasi-Experimental Study with Multimethod MonitoringEnsuring effective cleaning and disinfection (C/D) of operating room (OR) surfaces is essential for patient safety, yet available monitoring methods vary in performance and interpretation. This study aimed to assess changes associated with a multimodal intervention on C/D quality, compare the performance of four monitoring methods, and identify predictors of post-cleaning outcomes. A quasi-experimental pre–post study was conducted during 40 surgical procedures, totaling 1400 assessments across five high-touch surfaces. Monitoring included visual inspection, adenosine triphosphate (ATP) bioluminescence, microbiological culture (reference method), and a fluorescent marker. Sensitivity, specificity, and accuracy were calculated, and multivariable models were used to evaluate predictors of post-cleaning ATP levels. The methods showed distinct performance profiles: ATP demonstrated high specificity (93.9% and 86.7%) and accuracy (92.0% and 85.0%) but low sensitivity; visual inspection showed intermediate accuracy (62.0% and 44.0%); and the fluorescent marker demonstrated high sensitivity (100% in the first collection) but low specificity. The intervention period was associated with increased cleaning time and reduced post-cleaning ATP levels. Pre-cleaning ATP was the main predictor of post-cleaning ATP (p < 0.001), while surgical duration (p = 0.038) and surface type (p = 0.035) were associated in the second phase. These findings suggest that multimethod monitoring captures complementary dimensions of environmental hygiene and may support continuous quality improvement in surgical settings.Liliane Moretti Carneiro; Alvaro Francisco Lopes de Sousa; layze Braz de Oliveira; Elenir Rose Jardim Cury; André Luiz Silva Alvim; Hérica Emília Félix de Carvalho; Ana Carolina de Macedo Lima; Odinéa Maria Amorim Batista; Beatriz Soares dos Santos; Marcelo Alessandro Rigotti; Aires Garcia dos Santos; Adriano Menis Ferreira

Intervention (counseling); Hygiene; Visual inspection; Quality management; Continuous monitoring; Adenosine triphosphate; Medicine; Visual feedback

2026-06-04https://doi.org/10.3390/hygiene6020032Hygiene 20261Simulação Computacional do Deslocamento de Espuma Considerando a Adsorção de Surfactante em Meios Porosos HeterogêneosEste trabalho apresenta uma investigação numérica sobre o deslocamento de espuma em meios porosos heterogêneos, considerando os efeitos de adsorção de surfactante sob as abordagens em equilíbrio e cinética. O uso de surfactante para a geração de espuma reduz a mobilidade do gás frente a fase aquosa diminuindo os efeitos de \textit{fingering} viscoso e aumentando a eficiência de varredura do gás no meio poroso. Este problema é modelado pelo acoplamento da lei de Darcy e as equações de conservação de massa para as fases água e gás, juntamente com uma equação de transporte para o surfactante dissolvido. A solução numérica é obtida por meio de um algoritmo sequencial que combina um método de elementos finitos mistos híbridos, aplicado à hidrodinâmica, e um esquema de volumes finitos \textit{central-upwind} de alta ordem para o problema de transporte. As simulações avaliam as técnicas de coinjeção e injeção alternada de gás e surfactante (SAG), mostrando que o fenômeno de adsorção reduz a disponibilidade de surfactante na fase aquosa, limita a formação de espuma e diminui a eficiência de varredura do gás. Comparativamente, a estratégia SAG apresentou melhor desempenho quando comparada a coinjeção, devido à maior percolação do surfactante e consequente aumento da viscosidade aparente do gás com espuma. Os resultados confirmam que a adsorção de surfactante é um fator crítico na modelagem e na viabilidade de processos de recuperação avançada de petróleo assistidos por espuma.Filipe F. de Paula; Iury Igreja; Grigori Chapiro

Qualitative analysis; First order; Order (exchange); Humanities

2026-06-01https://doaj.org/article/70aa715cffb34b718bb64bc491aedba1DOAJ (DOAJ: Directory of Open Access Journals) 20261DifGa: differentiable error mitigation for multi-mode Gaussian and non-Gaussian noise in quantum photonic circuitsAbstract We present DifGa , a fully differentiable error-mitigation framework for continuous-variable photonic circuits under Gaussian loss and weak non-Gaussian phase noise. DifGa is an observable-level method: it targets first-moment quadratures <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" overflow="scroll"> <mml:mrow> <mml:mo fence="false" stretchy="false">⟨</mml:mo> <mml:msub> <mml:mrow> <mml:mover> <mml:mi>x</mml:mi> <mml:mo stretchy="true">^</mml:mo> </mml:mover> </mml:mrow> <mml:mn>0</mml:mn> </mml:msub> <mml:mo fence="false" stretchy="false">⟩</mml:mo> </mml:mrow> </mml:math> and <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" overflow="scroll"> <mml:mrow> <mml:mo fence="false" stretchy="false">⟨</mml:mo> <mml:msub> <mml:mrow> <mml:mover> <mml:mi>p</mml:mi> <mml:mo stretchy="true">^</mml:mo> </mml:mover> </mml:mrow> <mml:mn>0</mml:mn> </mml:msub> <mml:mo fence="false" stretchy="false">⟩</mml:mo> </mml:mrow> </mml:math> , rather than full-state recovery or fault-tolerant correction. Using PennyLane’s analytic default.gaussian backend, we model optical loss as beam-splitter coupling to vacuum ( <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" overflow="scroll"> <mml:mrow> <mml:mi>η</mml:mi> <mml:mo>∈</mml:mo> <mml:mo stretchy="false">[</mml:mo> <mml:mn>0.3</mml:mn> <mml:mo>,</mml:mo> <mml:mn>0.95</mml:mn> <mml:mo stretchy="false">]</mml:mo> </mml:mrow> </mml:math> ) and phase jitter via differentiable Monte-Carlo mixtures ( <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" overflow="scroll"> <mml:mrow> <mml:mi>δ</mml:mi> <mml:mo>∈</mml:mo> <mml:mo stretchy="false">[</mml:mo> <mml:mn>0</mml:mn> <mml:mo>,</mml:mo> <mml:mn>0.7</mml:mn> <mml:mo stretchy="false">]</mml:mo> </mml:mrow> </mml:math> ). A trainable Gaussian recovery layer (local rotations and displacements) is optimized end-to-end by automatic differentiation. In this analytic setting, the method reduces quadrature reconstruction loss by several orders of magnitude under Gaussian loss, reaching numerical residuals for moderate transmissivity; these values should be interpreted as moment-level numerical inversion in simulation, not full physical suppression of all noise channels. Under non-Gaussian jitter, noise-aware training improves robustness relative to Gaussian-only training, and a conservative 10%-of-baseline criterion yields an empirical mitigation threshold of <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" overflow="scroll"> <mml:mrow> <mml:msup> <mml:mi>δ</mml:mi> <mml:mo>∗</mml:mo> </mml:msup> <mml:mo>≈</mml:mo> <mml:mn>0.60</mml:mn> </mml:mrow> </mml:math> . Runtime scales approximately linearly with the Monte-Carlo sample count. DifGa remains fully within the Gaussian operation set and is consistent with Gaussian no-go theorems.Dennis Delali Kwesi Wayo; Rodrigo Alves Dias; Leonardo Goliatt; Sven Groppe

Gaussian; Differentiable function; Robustness (evolution); Jitter; Gaussian noise; Electronic circuit; Coupling (piping); Gaussian process; Mathematics; Algorithm; Quadrature (astronomy); Noise (video); Photonics; Physics; Control theory (sociology); Phase noise; Statistical physics

2026-06-05https://doi.org/10.1088/2515-7647/ae7864Journal of Physics Photonics 20261Psychometric properties of the Brazilian version of the Food Choice Questionnaire for Adolescents (FCQ-A-BR)Vanessa Sequeira Fontes; Felipe Silva Neves; Renata Maria Souza Oliveira; Eliane Rodrigues Faria; Michele Pereira Netto; Ana Paula Carlos Cândido

Discriminant validity; Intraclass correlation; Confirmatory factor analysis; Reliability (semiconductor); Convergent validity; Public health; Psychological intervention; Psychometrics; Internal consistency; Psychology; Clinical psychology; Structural equation modeling; Linear discriminant analysis; External validity

2026-06-05https://doi.org/10.21203/rs.3.rs-9817959/v1Research Square 20261Nordgren PINNs to VQE: Advancing Hydraulic Fracturing Simulations in Shale ReservoirsABSTRACT This study advances hydraulic fracturing simulations in shale reservoirs using two computational paradigms, Physics‐Informed Neural Networks (PINNs) and the Variational Quantum Eigensolver (VQE). PINNs were employed to solve Nordgren's equation, which governs fracture width evolution, by embedding physical laws into the neural network architecture. Using TensorFlow on Google Colab, the PINN training process incorporated Adam, L‐BFGS, and Newton‐CG optimizers, reaching a final loss of for a representative benchmark case (e.g., fluid viscosity = 8.0 , fracture height = 2.0 m, and leak‐off coefficient = 1.0); these parameters are used for comparison and are not tied to a specific field dataset. However, this approach demands computational resources, with training times exceeding 1454 s and memory usage of 1136 MB. Conversely, the VQE framework leveraged Qiskit on Qbraid to optimize the Hamiltonian representing the fracture system in practice. With qubit‐based ansatz circuits and classical optimizers (SPSA, COBYLA, and L‐BFGS), VQE achieves energy minimization, converging to ‐0.583+0j in under 2 s with low memory requirements. Spatiotemporal fracture width predictions from VQE align with trends but exhibit slight oscillations due to quantum noise. This comparative study highlights a trade‐off: PINNs show stronger physics‐consistent accuracy in the tested cases, while VQE provides lower runtime and memory use. These results suggest that combining PINN accuracy with VQE speed may be useful for decision‐support workflows in hydraulic fracturing. Future research will explore integrating these paradigms for scalable, high‐fidelity simulations across complex geological settings.Dennis Delali Kwesi Wayo; Sonny Irawan; Mohd Zulkifli Bin Mohamad Noor; Mudasar Zafar; Shynar Juziyeva; Camila Martins Saporetti; Leonardo Goliatt; Randy Hazlett

Hydraulic fracturing; Ansatz; Benchmark (surveying); Workflow; Quantum; Oil shale; Fracture (geology); Computer science; Artificial neural network; Hydrogeology; Hamiltonian (control theory)

2026-06-05https://doi.org/10.1002/nag.70359International Journal for Numerical and Analytical Methods in Geomechanics 20261Interactive mHealth Applications for Caregiver Training in Urinary Catheterization: A Scoping ReviewBackground/Objectives: Urinary catheterization is common across care settings, but safe management at home and during care transitions often depends on caregivers who receive limited and inconsistent training. Mobile health (mHealth) applications may support caregiver education and decision-making. This review mapped and synthesized evidence on interactive mobile applications for caregiver training in urinary catheterization and developed a conceptual framework to inform nursing practice. Methods: A scoping review was conducted according to Joanna Briggs Institute guidance and reported following PRISMA-ScR. Searches were performed in PubMed/MEDLINE, Scopus, Web of Science, and LILACS, with complementary grey literature searches. Studies evaluating interactive mobile applications for caregiver training in urinary catheterization were included. Data were extracted and synthesized descriptively and narratively. Results: Five studies published between 2020 and 2025 were included. Most were early-stage studies with small samples and heterogeneous designs. Interventions generally combined educational content with interactive features, such as decision-support tools, and less often behavioral strategies, including reminders and feedback. Outcomes mainly addressed knowledge, skills, and self-efficacy, while clinical outcomes, such as infection reduction, were rarely assessed. A conceptual framework was developed showing how intervention components may influence caregiver competence and care outcomes, moderated by contextual factors such as health literacy and digital access. Conclusions: Interactive mobile applications may represent a promising approach to support caregiver training and improve the safety of urinary catheter management. However, current evidence remains preliminary and limited.Hortência Fernandes; layze Braz de Oliveira; Marília Duarte Valim; Hérica Emília Félix de Carvalho; Daniela Reis Joaquim de Freitas; André Luiz Silva Alvim; Daniel de Macedo Rocha; Aires Garcia dos Santos; Beatriz Maria Jorge; I Fronteira; Álvaro Francisco Lopes de Sousa

mHealth; Competence (human resources); Psychological intervention; eHealth; Conceptual framework; Digital health; Intervention (counseling); Nursing Interventions Classification; Health care; Nursing; Medicine; Mobile technology; Medical education; Grey literature; Psychology; Health informatics; MEDLINE; Urinary incontinence; Mobile device; Telemedicine; Nurse education

2026-06-05https://doi.org/10.3390/nursrep16060194Nursing Reports 20261Hand preference shows limited influence on the magnitude but modulates the directional organization of upright posture control during a reaching and grasping task: a cross-sectional study in healthy womenBACKGROUND: According to the Dynamic Dominance Model (DDM), the dominant (preferred) and non-dominant (non-preferred) upper limbs are specialized for different control mechanisms, which may influence postural regulation during goal-directed manual actions. AIM: To compare postural control during a reaching and grasping task performed in an upright posture with the preferred and non-preferred upper limbs across different movement directions. METHODS: Thirty right-handed participants performed a reaching and grasping task in multiple directions and movement conditions using both upper limbs. Postural control was assessed using a force platform by analyzing the center of pressure (CoP) area, orientation (major elliptical axis), mean velocity, antero-posterior and medial-lateral excursion, and their lateral symmetry indices (LSIs). LSI values were compared to zero using t-tests, and task conditions were analyzed using repeated-measures ANOVA. RESULTS: Traditional CoP measures (area, velocity, and antero-posterior and medial-lateral excursion) did not differ across limbs or task conditions (all P-values > 0.065). However, the elliptical major angle revealed significant task- and limb-dependent effects, indicating changes in the directional organization of postural sway. INTERPRETATION: Although upper limb preference did not influence the magnitude of postural sway, it modulated the spatial organization of postural control. Within the DDM, these findings suggest that lateralized control mechanisms may affect coordination strategies rather than global stability. Thus, postural adjustments during upright reaching and grasping appear to be shaped by both task demands and limb-specific organization, even when overall stability is preserved.Fernanda N. Barbosa; Marco A. C. Garcia; Diogo S. Fonseca; Victor H. A. Okazaki; Lidiane A. Fernandes; Thiago Lemos

Task (project management); Center of pressure (fluid mechanics); Orientation (vector space); Motor control; Dominance (genetics); Preference; Upper limb; Physical medicine and rehabilitation; Psychology; Control (management); Movement (music); Affect (linguistics); Body posture

2026-06-05https://doi.org/10.20338/bjmb.v20i1.520Brazilian Journal of Motor Behavior 20261Sombrero vesicles: from overlooked structures to primary mediators of eosinophil secretionEosinophils, cells of the innate immune system, have a unique architecture, which includes morphologically complex secretory granules and a prominent, activation-responsive vesiculotubular system. In human eosinophils, this system is collectively termed eosinophil sombrero vesicles (EoSVs) because of its peculiar morphology feasibly identifiable by transmission electron microscopy. Considered as "microgranules" or "small granules" in the past, EoSVs are currently defined as active components of the eosinophil secretory pathway, sprouting from specific granules and trafficking granule-derived products in the eosinophil cytoplasm. Eosinophil secretory proteins associated with EoSVs include cationic proteins, cytokines, cytokine receptors, membrane fusion complexes, and tetraspanins. Beyond the intracellular landscape, emerging evidence has revealed a more complex functional repertoire for EoSVs. This review offers an overview of EoSVs as key participants in the mechanisms of eosinophil secretion during immune responses, incorporating the recent understanding of these transport carriers as extracellular vesicles, potentially implicated in the traffic of eosinophil products in the extracellular medium and intercellular communication.Rossana C N Melo; Peter F Weller

Eosinophil; Secretion; Eosinophil cationic protein; Extracellular; Innate immune system; Eosinophil peroxidase; Immune system; Intracellular; Biology; Cell biology; Immunology; Major basic protein; Secretory protein; Secretory Vesicle; Allergic inflammation; Inflammation; Exocytosis; Cytokine

2026-06-04https://doi.org/10.1093/jleuko/qiag072Journal of Leukocyte Biology 20261Heparin-like compounds improve the biophysical properties of eosinophilic mucusBACKGROUND: In eosinophilic chronic rhinosinusitis (ECRS), eosinophil extracellular traps (EETs) formed via extracellular trap-forming cell death contribute to abnormal mucus properties, including increased viscosity and hydrophobicity, which exacerbate disease progression. This study aimed to determine the modulatory effects of heparin-like compounds on the viscosity, hydrophilicity, and water content of EET-rich mucus in ECRS, and to assess their potential as adjunctive agents in enhancing mucolytic efficacy. METHODS: Mucus samples obtained from six patients with ECRS were treated with heparin-like compounds, including unfractionated heparin, mucopolysaccharide polysulfate (MPS), and dalteparin. Shear viscosity was measured using a rotational viscometer, hydrophobicity was assessed by contact-angle measurements, and water content was determined by thermogravimetric analysis based on time-dependent weight changes and final dry weight. The effects of these compounds on EETs were evaluated using peripheral blood-derived eosinophils in vitro. RESULTS: Treatment with heparin-like compounds, similar to unfractionated heparin, reduced the viscosity of ECRS mucus and EET aggregates while increasing both the water content and hydrophilicity. These compounds also promoted the relaxation of EET structures, and co-treatment with DNase further enhanced mucus dissolution. Increased turbidity upon mixing with histones indicated a direct interaction between heparin-like compounds and histones. CONCLUSIONS: These findings suggest that heparin-like compounds interact with EET-associated histones and alter the mucus polymer network, thereby improving the biophysical properties of pathological mucus by reducing its viscosity and enhancing its hydrophilicity.Misaki Arima; Tomoe Abe; Sahoko Kodama; Keisuke Ito; Keinosuke Hizuka; Hiroki Tomizawa; Yui Miyabe; Mineyo Fukuchi; Rossana C. N. Melo; Yoshinori Matsuwaki; Shigeharu Ueki

Mucus; Eosinophil; Extracellular; Viscosity; Extracellular polymeric substance; Flocculation; Eosinophilic; Chemistry; Microbiology; Biophysics; Biochemistry; Turbidity; Apparent viscosity; Eosinophilic esophagitis; Ingestion; Mucociliary clearance; Mucin

2026-06-01https://doi.org/10.1016/j.alit.2026.05.002Allergology International 20261Odontologia digital na reabilitação oral: impactos dos sistemas CAD/CAM na precisão e previsibilidade dos tratamentosA odontologia digital tem promovido importantes transformações nos processos de diagnóstico, planejamento e execução dos tratamentos reabilitadores, destacando-se os sistemas Computer-Aided Design/Computer-Aided Manufacturing (CAD/CAM) como uma das principais inovações tecnológicas aplicadas à prática clínica contemporânea. O presente estudo teve como objetivo analisar os impactos dos sistemas CAD/CAM na precisão e previsibilidade dos tratamentos de reabilitação oral por meio de uma revisão integrativa da literatura. A busca bibliográfica foi realizada nas bases de dados PubMed/MEDLINE, ScienceDirect e SciELO, contemplando publicações indexadas entre 2015 e 2025. Após a aplicação dos critérios de inclusão e exclusão, 12 estudos compuseram a amostra final da revisão. Os resultados evidenciaram que os sistemas CAD/CAM apresentam desempenho satisfatório quanto à adaptação marginal e interna das restaurações, contribuindo para maior precisão protética e previsibilidade clínica dos tratamentos. Além disso, os fluxos digitais demonstraram potencial para otimizar os processos clínicos e laboratoriais, reduzir o tempo de tratamento, melhorar a comunicação entre profissionais e aumentar a satisfação dos pacientes. Entretanto, limitações relacionadas à complexidade dos casos clínicos, à curva de aprendizagem dos profissionais e aos custos de implementação ainda representam desafios para a ampla utilização dessas tecnologias. Conclui-se que os sistemas CAD/CAM constituem ferramentas eficazes na reabilitação oral contemporânea, promovendo ganhos significativos em precisão, eficiência e previsibilidade dos tratamentos.Lucas Augusto Gonçalves Figueiredo; TÚLIO FERNANDES DE SOUZA; Rebeca Vidal Capelupi; André Luiz Rapchan Mattos; Renato Mendes Almeida

Digital health; Sample (material); Data collection; Transmission (telecommunications); Computer science; Physics; Materials science

2026-06-08https://doi.org/10.55892/jrg.v9i20.3470Revista JRG de Estudos Acadêmicos 20261The CYGNO experiment: a gaseous TPC with optical readout for rare events searchesAbstract The CYGNO collaboration is developing a novel strategy for directional Dark Matter searches based on a gaseous Time Projection Chamber (TPC). The detector is optimized for the exploration of light (0.5–50 GeV) WIMPs-like particles and employs a He/CF 4 gas mixture at atmospheric pressure, sensitive to both spin-dependent and spin-independent interactions. A key feature of the project is its optical readout, which relies on photon detection rather than charge collection. In CYGNO detectors, electrons released by ionizing tracks drift toward an amplification stage of three Gas Electron Multipliers (GEMs). The electron avalanches generate scintillation light that is captured by scientific CMOS (sCMOS) cameras for high-resolution two-dimensional imaging and by Photomultiplier Tubes (PMTs) that provide a precise time profile along the drift direction. This allows a 3D event reconstruction, detailed energy deposition mapping, and effective topology and head-to-tail discrimination. Building on the achievements of the 50 L prototype (LIME), which successfully operated underground at LNGS, the next step is the deployment of a 0.4 m 3 demonstrator, CYGNO-04, to be completed in 2026. The demonstrator will validate scalability and confirm the advantages of the proposed technique. Recent results from LIME highlight strong progress in 3D tracking and particle identification. The current status of CYGNO-04 and its role in advancing the program will be presented as well.F.D. Amaro; R. Antonietti; E. Baracchini; L Benussi; C. Capoccia; M. Caponero; L. G. M. de Carvalho; G. Cavoto; I. A. Costa; A. Croce; M. D'Astolfo; G. D'Imperio; G. Dho; E. Di Marco; J.M.F. dos Santos; D. Fiorina; F. Iacoangeli; Z. Islam; H. P. Lima; G. Maccarrone; R. D. P. Mano; D. J. G. Marques; G. Mazzitelli; P. Meloni; A. Messina; C.M.B. Monteiro; R.A. Nobrega; I.F. Pains; E. Paoletti; F. Petrucci; S. Piacentini; D. Pierluigi; D. Pinci; F. Renga; A. Russo; G. Saviano; P.A.O.C. Silva; N.J.C. Spooner; R. Tesauro; S. Tomassini; S. Torelli; D. Tozzi

Time projection chamber; Scintillation; Photomultiplier; Tracking (education); Photon; Detector; Electron; Scalability; Gas electron multiplier; Physics; Optics; Event (particle physics); Cathode; Projection (relational algebra); Scintillator; Particle detector; Computer science; CMOS; Feature (linguistics); Optoelectronics

2026-06-01https://doi.org/10.1088/1748-0221/21/06/c06006Journal of Instrumentation 20261Development and efficacy of a cognitive dissonance-based intervention program for intuitive eating: A randomized controlled clinical trialIntuitive eating is an approach that encourages individuals to eat according to their body's hunger and satiety cues. Intuitive eating interventions vary in methodology, lack time-based monitoring, and are often not based on all intuitive eating principles. Therefore, this study aimed to develop and evaluate the efficacy of an intuitive eating intervention using cognitive dissonance strategies to increase intuitive eating, positive body image, and health-related motivation for physical exercise, as well as to reduce disordered eating behaviors. Brazilian women (n = 110) aged 18-35 were randomly assigned to one of three groups: cognitive dissonance, educational, and passive control. Intention-to-treat analysis was performed using the mixed-effects models to assess the efficacy of the cognitive dissonance intuitive eating intervention, comparing effects between groups and each outcome over time (baseline, post-intervention, four-, 24-, and 48-weeks of follow-up). The cognitive dissonance intervention showed increases in body appreciation, internal body orientation, health motivation for physical exercise, and a reduction in restrictive eating post-intervention. At 24- and 48-week follow-ups, there were increases in all outcomes and reductions in scores for restrictive, uncontrolled, and emotional eating. Overall, the cognitive dissonance group showed statistically significant differences compared to the other groups in most outcomes. Effect sizes ranged from small to large. The results showed the efficacy of the cognitive dissonance intervention in promoting intuitive eating and positive body image, as well as reducing disordered eating behaviors. It can be used to prevent body image disturbances and disordered eating, constituting an important additional tool for addressing these issues.Thainá Richelli Oliveira Resende; Marle dos Santos Alvarenga; Pedro Henrique Berbert de Carvalho

Cognitive dissonance; Cognition; Intervention (counseling); Psychological intervention; Randomized controlled trial; Disordered eating; Eating disorders; Psychology; Clinical psychology; Self-efficacy; Clinical trial; Cognitive Intervention; Healthy eating; Developmental psychology

2026-06-08https://doi.org/10.1016/j.bodyim.2026.102129Body Image 20261Determination of turbidity in a drinking water reservoir from UV–Vis absorption spectra with multivariate modeling.This study evaluates ultraviolet–visible (UV–Vis) spectroscopy as a quantitative approach for turbidity detection in clear freshwater systems, where conventional methods often show limited sensitivity and reduced accuracy at low particle concentrations, particularly in reservoirs used for drinking water supply, where maintaining low turbidity is essential. Water samples were collected in 26 surface and bottom sampling sites, totaling 52 samples, along a clear water drinking water supply reservoir. The samples were analyzed using UV–Vis spectrophotometry (200–900 nm). Principal Component Analysis (PCA) was applied to identify spectral patterns, and Partial Least Squares (PLS) regression was used to develop predictive models for turbidity based on absorbance spectra. The first two PCA components explained 91% of the total variance, and clearly distinguished surface and bottom samples, indicating consistent spectral differences associated with vertical gradients. The PLS model showed a strong correlation (0.71 R 2 ) between predicted and measured turbidity, demonstrating reliable performance under low turbidity conditions. These results indicate that UV–Vis spectroscopy enhances sensitivity in clear waters and enables the detection of subtle variations in suspended particles, overcoming limitations of conventional methods. Given the contrasting results reported in the literature regarding the application of spectroscopy to water samples, this study contributes to improving the use of this technique. Also, by integrating spectral analysis with multivariate calibration, this study refines turbidity assessment in freshwater systems and advances the validation of in situ measurements, providing a non-invasive approach for water quality monitoring and sediment dynamics evaluation.Ilza Santos; Patrícia Nunes; Maria Clara Baldow; Emanuelle Gianini; Daniel Merhy; Fábio Roland; Maria Jose Bell; Virgílio Anjos

Turbidity; Multivariate statistics; Water reservoir; Absorption (acoustics); Absorption spectroscopy; Spectral line; Parts-per notation; Chemistry; Environmental chemistry; Analytical Chemistry (journal); Turbidite; Multivariate analysis; Water quality

2026-06-08https://doi.org/10.1016/j.saa.2026.128221Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy 20261P-Selectin and Platelet–Monocyte Interaction in Inflammation: Mechanisms, Hypothesis, and Open QuestionsThis review provides an integrated overview of how P-selectin-mediated platelet-monocyte interactions orchestrate key inflammatory processes in sterile and non-sterile pathological contexts. Inflammation presents a paradox: although it is a fundamental physiological process, uncontrolled activation can progress to a chronic state, contributing to the development of various inflammatory diseases. Platelets, previously considered to play a role exclusively in hemostasis, are now recognized as important immunomodulatory effectors capable of releasing inflammatory mediators and interact with leukocytes upon activation. The interaction between platelet P-selectin and monocyte PSGL-1 promotes the formation of platelet-monocyte aggregates, that together exert broad and profound inflammatory effects. These aggregates have been implicated in multiple pathological contexts, both sterile, such as atherosclerosis, obesity, autoimmune diseases, and hypertension, and non-sterile, such as sepsis and viral infections, highlighting their role as a common axis of immune and inflammatory regulation. This review integrates shared but contextualized mechanistic pathways and outlines current hypotheses regarding how platelet-monocyte interactions may operate in sterile and pathogen-induced inflammation. We further discuss emerging evidence connecting P-selectin signaling to metabolic reprogramming, vascular dysfunction, and immunothrombosis, as well as its possible influence on monocyte activation and phenotype in diverse inflammatory settings, discussing open questions, perspectives, and challenges in the field. By integrating interdisciplinary findings, this review highlights P-selectin-dependent platelet-leukocyte interactions as central axis in inflammation and promising therapeutic targets.Mayara Karen Fernandes; Marcelo De Paula; Renata Oliveira; João Pedro Dos Santos; Maria Clara Mancini; Eugenio Hottz

Identification (biology); Focus (optics); Quality (philosophy); Perspective (graphical); Computer science

2026-06-01https://doi.org/10.2147/jir.s556871Journal of Inflammation Research 20261Constituição de sujeitos masculinos homossexuais no Twitter: pedagogias nos rastros dos discursosO artigo apresenta parte das análises de uma pesquisa, cuja centralidade voltava-se ao rastreio de discursos operando sobre corpos de sujeitos homossexuais masculinos na rede social Twitter. Considerou-se o referencial foucaultiano para tomar os discursos e seus efeitos sobre as subjetividades a partir do exercício de relações de saber-poder. A navegação pelo Twitter foi em busca de enunciações, recolhendo tuítes que se ligavam aos discursos da sexualidade e da medicalização e como eles vêm funcionando para educar modos específicos de pensar o corpo, a masculinidade, a homossexualidade, em tempos de sexualidades ciborgues e da significativa presença da Internet na vida cotidiana. Desse modo, é discutido que, por meio do Twitter, fala-se prolixamente sobre corpo e sexualidade, a partir de estratégias de exposição de práticas e desejos e do controle de si e do outro usando os recursos próprios da rede social (postar, curtir, comentar, compartilhar).Cláudio Orlando Gamarano Cabral; Roney Polato de Castro

Human sexuality; Subject (documents); The Internet; Qualitative research; Identity (music); Social group; Social life; Sociology

2026-03-25https://doi.org/10.33871/nupem.2026.18.43.10538Revista NUPEM 20261PROMOÇÃO DA SAÚDE E COMPORTAMENTO SEDENTÁRIO NA PERSPECTIVA DE SERVIDORES PÚBLICOS DE UMA UNIVERSIDADE FEDERAL DE MINAS GERAISEste estudo analisou a percepção de servidores públicos federais ocupantes do cargo de assistente em administração da Universidade Federal de Juiz de Fora acerca das ações institucionais de promoção da saúde e seu papel no enfrentamento do comportamento sedentário. Trata-se de uma pesquisa qualitativa de caráter descritivo-analítico, desenvolvida por meio de entrevistas semiestruturadas com servidores públicos federais na função de assistente em administração. Os dados foram tratados por análise de conteúdo com categorias de análise temática. Os resultados evidenciam a predominância de ações fragmentadas, com limitada integração intersetorial e forte dependência de iniciativas pontuais, o que compromete sua sustentabilidade. As percepções sobre promoção da saúde apontam para uma perspectiva individualizada centrada na prática de atividade física, em detrimento da consideração dos determinantes organizacionais e das condições de trabalho. O ambiente laboral se caracteriza majoritariamente por servidores com comportamento sedentário e inadequações ergonômicas, reforçando a necessidade de estrutura de qualidade no ambiente de trabalho. Conclui-se que a promoção da saúde no contexto analisado opera de forma parcial e desarticulada, demandando a superação de abordagens centradas no indivíduo e a incorporação de estratégias estruturais que integrem a saúde ao planejamento institucional e à organização do trabalho.Wander Delon de Moura Fontes; Patrícia Aparecida Baumgratz de Paula; Simone de Pinho Barbosa

Context (archaeology); Quality (philosophy); Public policy; Qualitative research; Political science; Humanities

2026-06-08https://doi.org/10.51891/rease.v12i6.26829Revista Ibero-Americana de Humanidades, Ciências e Educação 20261Ionic liquid induced structural transformation in a copper-based MOF synthesis: Experimental and DFT investigationsThe development of advanced materials for carbon management has driven significant interest in hybrid systems based on metal-organic frameworks (MOFs) and ionic liquids (ILs), owing to their tunable structures and enhanced affinity for CO2. In this study, we demonstrate that the IL [BMIm][BF4], employed as an ionothermal medium, plays a dual role as both solvent and structure-directing agent, enabling the formation of a two-dimensional copper-terephthalate network (Cu-BDC-2), which differs from the material obtained via conventional solvothermal synthesis (Cu-BDC-1). Structural and spectroscopic analyses reveal that IL-derived species remain associated with the framework surface, directly influencing its physicochemical properties. CO2 adsorption measurements at 85 °C show that Cu-BDC-2 exhibits enhanced interactions with CO2, attributed to the effect of IL-derived species. In contrast, theoretical calculations indicate that, in Cu-BDC-1, van der Waals interactions between CO2 and the aromatic linkers dominate the adsorption process. Furthermore, the GFN1 - xTB method shows good agreement with DFT + U results, highlighting its potential as a computationally efficient approach for screening such systems. These findings demonstrate that ionothermal synthesis is an effective strategy for modulating both the structure and surface functionality of MOF-based materials, opening new perspectives for their applications.Jarede Da Silva Martins; Carolina B. P. Ligieiro; Rodrigo S. Bitzer; Yann Maia; Odivaldo C. Alves; Sara S. Vieira; Paulo Henrique de Melo Toledo; Gustavo F. S. Andrade; Thiago M. Rossi; Mariana M.V.M. Souza; Célia M. Ronconi; Luciano T. Costa

Ionic liquid; van der Waals force; Adsorption; Density functional theory; Solvent; Dual (grammatical number); Materials science; Chemical physics; Ionic bonding; Carbon fibers; Nanotechnology; Transformation (genetics); Computational chemistry

2026-06-09https://doi.org/10.1063/5.0335653The Journal of Chemical Physics 20261Systematic Review of Computational Models of Autoimmune Demyelinating Brain Diseases and Their Biological CorrelatesMultiple Sclerosis (MS) is a chronic, neuroinflammatory diseaseof the central nervous system. Studying its progression presentssignificant hurdles. Research on human patients requires lengthyfollow-up periods and necessitates stringent approval from ethicscommittees. Meanwhile, induced MS in animal (murine) modelsprovides only an approximation of the human condition; theirresults may not translate to humans and are governed by strictethical precautions. These limitations highlight the critical needfor alternative research methodologies to accelerate understandingand therapeutic development. In this context, computational (insilico) modeling offers a powerful parallel approach. This technique uses mathematical frameworks to simulate highly complexsystems, allowing months of disease progression to be analyzedin minutes, free from the ethical constraints of biological studies.However, a multitude of computational models exist, each basedon specific hypotheses about the disease’s mechanisms, creatinga fragmented landscape. This paper addresses this gap through asystematic literature mapping. From an initial pool of 199 studies,49 relevant articles were selected. The primary contribution is identifying mathematical models that can be integrated, aiming to builda more comprehensive simulation framework that covers a broaderspectrum of the disease’s developmental stages, thereby fostering amore holistic understanding of MS.Marcela G. Pinheiro; Júlia G. Pinheiro; Matheus Ávila M. de Paula; Bárbara M. Quintela

Computational model; Multiple sclerosis; Demyelinating disease; Computational simulation; Disease; Autoimmune disease; Neuroscience; Medicine; Computer science

2026-06-09https://doi.org/10.14210/cotb.v17.p722-724Anais do Computer on the Beach 20261Health data poverty in low-income and middle-income countries: a challenge for climate justiceIn a Health Policy paper in The Lancet Global Health, Ruby Syal and colleagues provide a timely framework for research priorities regarding the impacts of climate change on the health of women and children in low-income and middle-income countries (LMICs).1 The application of the Child Health and Nutrition Research Initiative method identifies vulnerability mapping (2nd highest prioritised research question) and the integration of climate metrics into surveillance systems (3rd highest prioritised research question) as primary objectives.Felipe Silva Neves; Larissa Loures Mendes; Paula Martins Horta; Raquel Canuto

Vulnerability (computing); Poverty; Climate change; Global health; Public health; Economic Justice; Health policy; MEDLINE; Economic growth; Political science; Environmental health; Environmental planning; Environmental resource management; Social justice; Climate justice; Inequality

2026-06-09https://doi.org/10.1016/j.langlo.2026.103990The Lancet Global Health 20261ABORDAGEM TERAPÊUTICA E MANEJO ANTIMICROBIANO NO TRATAMENTO DA INFECÇÃO DO TRATO URINÁRIO (ITU) EM FELINOSA infecção do trato urinário (ITU) em felinos é uma importante patologia na medicina veterinária, podendo apresentar-se como ITU não complicada, sendo diagnosticada em animais saudáveis, ou como ITU complicada, estando associada a doenças concomitantes, como diabetes mellitus, doença renal crônica, hipertireoidismo, alterações anatômicas do trato urinário, entre outras. A Escherichia coli é a principal bactéria envolvida na etiologia da doença, seguida por espécies de Staphylococcus. Infecções fúngicas, especialmente por Candida albicans, também podem ocorrer caso o animal esteja imunossuprimido ou tenha sido submetido ao uso prolongado de antimicrobianos. O diagnóstico adequado deve incluir exames de sangue, como hemograma e perfil bioquímico, urinálise, urocultura e antibiograma, sendo que a cultura quantitativa de urina é considerada o padrão-ouro para confirmação da infecção. O aumento da resistência microbiana aos fármacos disponíveis tem representado um desafio crescente, destacando a necessidade da utilização racional de antimicrobianos e da adoção de programas de stewardship antimicrobiano. As diretrizes atuais recomendam a escolha terapêutica baseada em exames laboratoriais, priorizando medicamentos de menor impacto na saúde pública e restringindo o uso de fármacos de amplo espectro em situações específicas. Além da importância clínica, as ITUs felinas apresentam relevância em saúde pública devido ao potencial zoonótico de bactérias multirresistentes entre animais e seres humanos.Júlia Mayumi Imamura; Laura Gonçalves Maciel; Hermeson Nobrega Barros de Oliveira Junior; Leticia de Souza Lecheski de Oliveira; Maysa Bonades Marcondes

Urinary system; Kidney; Gastrointestinal tract; Medicine; Pathology; Biology

2026-06-09https://doi.org/10.56238/iimulticientifica-060 20261Integrated cytogenomic analysis of Physalis germplasm using CMA/DAPI chromosome banding and flow cytometryErison Martins Souza; Elyabe Monteiro de Matos; Lyderson Fácio Viccini; Natoniel Franklin Melo; Gabriela Torres Silva; Adriana Rodrigues Passos; Luiz Cláudio Costa Silva

Germplasm; Ploidy; Chromosome; Genome; Genome size; Heterochromatin; Karyotype; Polyploid; Biology; Genetics; Genetic diversity; Cytogenetics; Evolutionary biology; Nuclear DNA

2026-06-09https://doi.org/10.21203/rs.3.rs-9809513/v1Research Square 20261UFVBeefChain: Estudo de Caso da Rastreabilidade da Carne no Frigorífico Escola da UFV com BlockchainThis paper introduces UFVBeefChain, a case study conducted at the Teaching Slaughterhouse of the Federal University of Viçosa (UFV), applying Blockchain technology to beef traceability. The study emphasizes traceability as a tool for food safety, transparency, and consumer trust, while pointing out the limitations of traditional centralized systems. The proposed architecture integrates IoT sensors, smart contracts, and a decentralized application (dApp) to record data from farm to commercialization, including birth, vaccination, slaughter, meat cuts, and storage information. Consumers can access this data through a Quick Response Code (QR code), ensuring the immutability and reliability of records. The case study with nine animals confirmed the technical feasibility of the solution, highlighting Blockchain’s potential to modernize and secure the beef production chain.Ronan D. Mendonça; Josué N. Campos; Hiago H. R. Zanetoni; Andre L. de F. Coelho; Daniel M. Queiroz; Alex B. Vieira; José A. M. Nacif

Traceability; Immutability; Blockchain; Production (economics); Smart contract; Internet of Things; SAFER; Business; Reliability (semiconductor); Computer security; Computer science; Agricultural science; Food processing

2026-05-25https://doi.org/10.5753/wblockchain.2026.23216 20261Frequência escolar em indivíduos com paralisia cerebral no BrasilObjetivo Identificar fatores associados à frequência escolar entre crianças, adolescentes e jovens adultos brasileiros com paralisia cerebral (PC), utilizando dados populacionais do Registro Brasileiro de Paralisia Cerebral (RBPC). Método Este estudo transversal analisou dados de 774 indivíduos com PC, com idades entre 4 e 21 anos, registrados no RPBC. As variáveis incluíram características sociodemográficas e clínicas (Sistema de Classificação da Função Motora Grossa, Sistema de Classificação das Habilidades Manuais e limitações de fala), além da frequência escolar. Foram realizadas análises descritivas e modelos de regressão logística multivariável foram aplicados para estimar odds ratio ajustadas (aORs) com seus respectivos intervalos de confiança de 95% (IC95%). Resultados Entre os participantes, 76% frequentavam a escola, embora 62% não soubessem ler e escrever. Adolescentes com PC entre 13 e 21 anos apresentaram menor probabilidade de frequentar a escola em comparação àqueles entre 4 e 12 anos (aOR = 0,49; IC95% = 0,3–0,7), assim como aqueles classificados nos níveis IV e V do Sistema de Classificação da Função Motora Grossa em comparação aos níveis I a III (aOR = 0,29; IC95% = 0,1–0,4). Além disso, a presença de limitações de fala esteve associada à menor frequência escolar (aOR = 0,12; IC95% = 0,1–0,3). Interpretação Embora as taxas de frequência escolar de indivíduos brasileiros com PC sejam relativamente altas em comparação a outros países de baixa e média renda, importantes barreiras persistem. O enfrentamento de aspectos relacionados ao suporte à comunicação e à inclusão relacionada à mobilidade é essencial para melhorar tanto a frequência escolar quanto o envolvimento significativo.Ricardo Rodrigues de Sousa; Luana Cristina da Silva; Ana Cristina Resende Camargos; Eliane Beatriz Cunha Policiano; Livia Coutinho; Nadia Badawi; Israt Jahan; Gulam Khandaker; María de las Mercedes Ruiz Brünner; Paula Silva de Carvalho Chagas; Hércules Ribeiro Leite

Cerebral palsy; Odds; Cognition; Special education; Psychology; Humanities; Developmental psychology

2026-06-10https://doi.org/10.1111/dmcn.70341Developmental Medicine & Child Neurology 20261Debate historiográfico e usos do passado na construção do exílio babilônico na Bíblia HebraicaUm dos eventos mais importantes na cronologia interna da Bíblia Hebraica é o chamado “Exílio Babilônico”, no qual os habitantes de Judá teriam sido deportados para a Babilônia após o ocaso do reino judaíta, situado na primeira metade do século VI AEC. Embora a documentação bíblica e extrabíblica ateste deportações, a construção literária bíblica sobre esse tema é profundamente ideológica, refletindo a visão da elite judaíta exilada e desconsiderando ou caracterizando negativamente os grupos que permaneceram em Judá. Questiona-se, assim, em que medida tais textos contêm memórias históricas. Apresentamos dois grupos interpretativos: um que minimiza seu valor histórico e outro que admite a preservação de elementos históricos. Como metodologia, empregamos um levantamento historiográfico, por meio do qual analisamos criticamente os principais argumentos dos autores selecionados, colocando-os em diálogo.Marciléia Pereira Do Carmo

Elite; Context (archaeology); Ethnography; Humanities; History; Philosophy; Art; Political science

2026-06-05https://doi.org/10.35699/1982-3053.2026.65260Arquivo Maaravi Revista Digital de Estudos Judaicos da UFMG 20261GLP-1 Receptor Agonists vs. SGLT2 Inhibitors and the Risk of Alzheimer’s Disease in Type 2 Diabetes: A Systematic Review and Meta-Analysis (N3.002)To evaluate whether the use of GLP-1 receptor agonists (GLP-1RAs) and SGLT2 inhibitors (SGLT2i) reduces the risk of Alzheimer’s disease (AD) and dementia in patients with type 2 diabetes (DM2).Levi Da Silva; Carolina Moura; Maria Valverde; Anderson M. Pereira da Silva; Luana Braz; Kauã Silva; Emanuel Aguiar; Vitor Volta; Clara de Oliveira; Filipi Andreão; Henrique Cal; Diogo Santos

Disease; Receptor; Agonist; Type 2 diabetes; Diabetes mellitus; Medicine; Pharmacology; Bioinformatics; MEDLINE

2026-06-09https://doi.org/10.1212/wnl.0000000000215416Neurology 20261La liquidación forzosa en el derecho concursal panameño: Configuración normativa en la Ley 12 de 2016, competencia jurisdiccional, dinámica procesal y tutela colectiva del créditoEl presente artículo examina la figura de la liquidación forzosa dentro del derecho concursal panameño, a la luz de la Ley 12 de 19 de mayo de 2016, como mecanismo de ejecución colectiva orientado a la realización ordenada del patrimonio del deudor insolvente. Se analiza su configuración normativa, los presupuestos objetivos que habilitan su procedencia, la competencia jurisdiccional de los tribunales concursales y la estructura inicial del procedimiento, con especial énfasis en la demanda, la oposición del deudor y la audiencia inicial. El estudio incorpora un enfoque dogmático-jurídico, integrando disposiciones específicas de la Ley 12 de 2016 y aportes de la doctrina panameña contemporánea, con el propósito de evidenciar la función del proceso de liquidación forzosa como instrumento de tutela colectiva del crédito bajo el principio de igualdad entre acreedores.Hilario González Ariza

Derecho; Context (archaeology); Order (exchange); Economic Justice; Political science; Humanities

2026-05-31https://doi.org/10.37594/cathedra.n25.2127Revista Cathedra 20261planilha_apos_a_remocao_ duplidades.txtArquivo utilizado para análiseCristian Kelly Costa Santos; Paulo Filipe Silva Siqueira; Waneska Alexandra Alves; Sibele Nascimento de Aquino

2026-01-01https://doi.org/10.48331/scielodata.ogynwg/kvnmg9SciELO - Scientific Electronic Library Online Dataverse

20261oportunidade.pdfArquivo do programa de análise de dados.Cristian Kelly Costa Santos; Paulo Filipe Silva Siqueira; Waneska Alexandra Alves; Sibele Nascimento de Aquino

2026-01-01https://doi.org/10.48331/scielodata.ogynwg/0chfujSciELO - Scientific Electronic Library Online Dataverse

20261Resilience paths: maternal experiences in coping with syphilis exposure or congenital infection and the role of support networksBACKGROUND: Congenital syphilis is a significant public health problem and can lead to several unfavorable perinatal outcomes and severe sequelae in children. In Brazil, the number of cases of congenital and gestational syphilis continues to increase, highlighting the need for timely diagnosis, treatment, and prevention. A lack of adequate follow-up during prenatal care may result in unwanted outcomes for the neonate, such as prolonged hospitalization and impacts on neurodevelopment. Although many studies have focused on the clinical aspects of congenital syphilis, there is a gap in understanding maternal experiences, especially regarding affective and psychological elements and the importance of support networks. OBJECTIVES: To explore the experiences of mothers of children exposed to syphilis during pregnancy or with congenital infection regarding the diagnosis and hospitalization of the child and the influence of their support networks. METHODS: This is a descriptive study with a qualitative approach based on the concept of social support networks. After ethical approval, individual and semi-structured interviews were conducted and submitted for content analysis. The study enrolled 11 mothers of children with congenital infection and two mothers of children exposed to gestational syphilis at an outpatient clinic in Juiz de Fora, Minas Gerais, Brazil. RESULTS: The guilt of the mother and her responsibility for the vertical transmission were identified. The women experienced feelings of sadness, doubts about the child, mistaken conception of the disease, and fear of the child's death. The experience was permeated by stigma and prejudice. The hospitalization of the child and the consequent need for invasive procedures was a moment of shock for the mother. The perspective of the child's well-being and the recognition of the benefits of the treatment, as well as faith and the presence of a support network, were fundamental in the process. CONCLUSION: The presence of a support network in the process of coping with congenital syphilis or exposure to infection can modulate maternal health. This highlights the need for health education and more inclusive actions in the context of maternal and child health from the time of prenatal care.Talia de Souza Fernandes Poggianella; Giovanna Cristina Conti Machado; Ana Lúcia de Lima Guedes; Natália Maria Vieira Pereira-Caldeira; Lise Maria Carvalho Mendes; Laís Celeste Medeiros Mendes Fonseca; Fernanda Maria Vieira Pereira-Ávila; Lucila Castanheira Nascimento; Flávia Azevedo Gomes-Sponholz; Nayara Gonçalves Barbosa

Congenital syphilis; Syphilis; Coping (psychology); Qualitative research; Pregnancy; Social support; Feeling; Public health; Reproductive medicine; Medicine; Psychiatry; Psychological intervention; Childbirth; Prenatal care; Psychological resilience; Family medicine; Treponematosis; Outpatient clinic; Health care; Pediatrics; Premature birth

2026-06-11https://doi.org/10.1186/s12884-026-09441-2BMC Pregnancy and Childbirth 20261caracterização_dos_casos_de_violência.pdfArquivo do programa de análise de dados.Cristian Kelly Costa Santos; Paulo Filipe Silva Siqueira; Waneska Alexandra Alves; Sibele Nascimento de Aquino

2026-01-01https://doi.org/10.48331/scielodata.ogynwg/komjnxSciELO - Scientific Electronic Library Online Dataverse

20261violencia_planilha_completo.txtSem dados que identificam as vítimasCristian Kelly Costa Santos; Paulo Filipe Silva Siqueira; Waneska Alexandra Alves; Sibele Nascimento de Aquino

2026-01-01https://doi.org/10.48331/scielodata.ogynwg/cynymxSciELO - Scientific Electronic Library Online Dataverse

20261caracterização_dos_casos_violência.tabCristian Kelly Costa Santos; Paulo Filipe Silva Siqueira; Waneska Alexandra Alves; Sibele Nascimento de Aquino

2026-01-01https://doi.org/10.48331/scielodata.ogynwg/t9bioiSciELO - Scientific Electronic Library Online Dataverse

20261Arquivo_README.txtCristian Kelly Costa Santos; Paulo Filipe Silva Siqueira; Waneska Alexandra Alves; Sibele Nascimento de Aquino

2026-01-01https://doi.org/10.48331/scielodata.ogynwg/e2p7d4SciELO - Scientific Electronic Library Online Dataverse

20261Novelties in Brazilian Lippia (Verbenaceae): two new species and two new synonymsLippia diamantinensis and L. glazioviana, described in Glaziou’s catalogue (1911), are considered not validly published. They represent distinct taxonomic entities within the genus and, in accordance with the International Code of Nomenclature for algae, fungi, and plants, are here formally described as new species: Lippia neodiamantinensis and L. neoglazioviana. The former is endemic to the Diamantina Plateau, Espinhaço Range, Minas Gerais state, and the second to the Chapada dos Veadeiros, Goiás state, both from Brazil. We provide descriptions, photographs, comparisons with morphologically similar species, a distribution map, and a preliminary conservation status assessment. Additionally, Verbena goyazensis and L. possensis are proposed as synonyms of L. herbacea and L. corymbosa, respectively.Pedro Henrique Cardoso; Marcelo Trovó; Jefferson Prado; Luiz Menini Neto; Fátima Regina Gonçalves Salimena

Lippia; Nomenclature; Taxonomy (biology); Eudicots; Taxon; Genus; Biology; Botany; Conservation status; Zoology; Specific name; Verbenaceae

2026-06-11https://doi.org/10.11646/phytotaxa.762.1.4Phytotaxa 20261Is There Life After Death? The Role of Standing Dead Phorophytes in Supporting Tropical Epiphyte DiversityABSTRACT Global increases in tree mortality from climate change and land‐use are altering forest structures, impacting canopy‐dwelling plants like vascular epiphytes, which depend on host trees (phorophytes). When a phorophyte dies standing, it becomes a snag, the local substrate conditions change and microclimatic exposure may increase, particularly in more canopy‐exposed individuals. The ecological role of snags in supporting epiphyte diversity remains poorly understood. We examined how snags contribute to epiphyte diversity in a dwarf cloud forest in southeastern Brazil. We surveyed 887 phorophytes (778 alive, 109 dead) across 24 plots, recording 127 epiphyte species. Snags, comprising 12% of phorophytes, supported 57% of the total epiphyte richness. Community composition on snags was a nested subset of that on living trees, with no species exclusive to dead phorophytes. Sample‐based rarefaction confirmed that, overall, snags supported significantly lower species richness ( q = 0) and dominant species diversity ( q = 2). Structurally, snags also differed significantly, being shorter, having smaller diameters (DBH), and rougher bark than living trees. While NMDS showed community structure correlated with elevation, height, and bark, this pattern was phorophyte‐species‐dependent. Contrary to the general trend, analysis of the dominant phorophyte Eremanthus erythropappus (“ candeia ”) revealed no significant differences in epiphyte richness ( q = 0) or dominant diversity ( q = 2) between living and dead individuals. Our results suggest snags function as secondary refuges, but their capacity to buffer epiphyte loss could be mediated by host species traits.Camila Nardy; Samyra Gomes Furtado; Luiz Menini Neto; Flávio Nunes Ramos

Epiphyte; Snag; Species richness; Cloud forest; Rarefaction (ecology); Biodiversity; Species diversity; Rainforest; Ecology; Biology; Coarse woody debris; Bark (sound); Host (biology); Dead tree; Frugivore; Nestedness

2026-06-10https://doi.org/10.1111/btp.70222Biotropica 20261oportunidade.tabCristian Kelly Costa Santos; Paulo Filipe Silva Siqueira; Waneska Alexandra Alves; Sibele Nascimento de Aquino

2026-01-01https://doi.org/10.48331/scielodata.ogynwg/ndwgcwSciELO - Scientific Electronic Library Online Dataverse

20261O CONCEITO DAS DIFERENÇAS NO CURRÍCULO CULTURAL A PARTIR DAS CONCEPÇÕES PÓS-ESTRUTURALISTAS: UMA REVISÃO INTEGRATIVAEsse artigo buscou analisar como o conceito de diferença é compreendido e abordado no Currículo Cultural da Educação Física, tomando como referência as contribuições das teorias pós-estruturalistas. Para isso, foi realizada uma revisão integrativa da literatura, com análise de dezoito artigos publicados entre os anos de 2019 e 2024, localizados em dois repositórios da área: o Grupo de Pesquisas em Educação Física Escolar (GPEF) e os Anais do Congresso Brasileiro de Ciências do Esporte (CONBRACE). Após a seleção dos estudos com base nos critérios de inclusão e exclusão, os dados foram examinados por meio da análise de conteúdo, organizados em duas categorias: fundamentação pós-estruturalista da diferença e concepções das diferenças no Currículo Cultural. Os resultados evidenciaram que essa proposta curricular rompe com perspectivas tradicionais e homogêneas de ensino, compreendendo a diferença como uma construção discursiva, relacional e política. Conclui-se que o Currículo Cultural valoriza os saberes marginalizados, fortalece a justiça curricular e reconhece a multiplicidade de sentidos da diferença no contexto escolar.Guilherme Henrique Bibiano Honório; L Martinelli Lucena Saar Silva; Ayra Lovisi Oliveira; Ludmila Mourão; Pedro Henrique Lobão; Matheus Benevides Dornas; Hanna Guimarães Santos

Ethnography; Context (archaeology); Cultural studies; Humanities; Philosophy

2026-06-12https://doi.org/10.51891/rease.v12i6.27000Revista Ibero-Americana de Humanidades, Ciências e Educação 20261Use of Mouthguards to Prevent Dental Trauma in Children: Case SeriesABSTRACT Objective: To assess the outcomes of mouth protector use in preventing further tooth injuries. Material and Methods: Participants were selected from those referred for care at the School of Dentistry, Federal University of Juiz de Fora, Brazil. The children were evaluated by dentists who provided necessary treatment after dental trauma incidents, including clinical examinations, radiographs, treatment of affected teeth, and impressions, fitting, and periodic adjustments of the mouth protector. To fabricate, patients first underwent an intraoral scan, which created a three-dimensional image of the dental arches. Based on this scan, the mouthguards were made from silicone with a thickness of 5 mm and delivered to the patients within one week. After adjustments were made using Maxicut and Minicut burs to ensure optimal fit. Results: Four children with varying histories of tooth injuries were followed. In three cases, no new trauma was reported after the introduction of a mouth protector. In the fourth case, a new trauma occurred when the mouth protector was not being used at the time of the incident. Despite initial adaptation challenges, most patients reported good acceptance and consistent use during sports activities. Conclusion: These cases reinforce the importance of mouth protectors as a preventive tool for children at high risk of tooth injuries and highlight the need for ongoing awareness to ensure regular use.B. Sales; Laís Canêdo Martins; Juliana Furtado Macedo; Fernanda Campos Machado; Camila Faria Carrada; Flávia Almeida Ribeiro Scalioni

Dental trauma; Tooth Fracture; Injury prevention; Poison control; Occupational safety and health; Medicine; Dentistry; Orthodontics

2026-01-01https://doi.org/10.1590/pboci.2026.089Pesquisa Brasileira em Odontopediatria e Clínica Integrada 20261Integrating Service Design in Corporate ArchitectureService Design is an interdisciplinary approach that structures all aspects of a service—people, communication, and infrastructure—making it more useful, desirable, and effective for users and providers alike. This article explores how Service Design principles can be integrated into corporate architecture, focusing on creating user-centered workspaces. Through a literature review and a practical workshop conducted with employees at the XXXX, the study demonstrates how Service Design tools can contribute to corporate workspace design by fostering user engagement and improving workflow, communication, and spatial functionality. The findings suggest that incorporating Service Design early in the architectural process enriches the design outcome by aligning spatial design with organizational objectives, employee needs, and service quality improvements.Mariane Unanue; Gicele Brittes; Frederico Braida; Rafael Noronha

Service design; Service (business); Organizational architecture; Workspace; Service provider; Service quality; Service delivery framework; Architecture; Process (computing); Process management; Knowledge management; Computer science; Outcome (game theory); Engineering; Business; Design process; Service level objective; Quality (philosophy); Service-oriented architecture; Engineering management

2026-04-24https://doi.org/10.4013/sdrj.2024.172.03.Strategic Design Research Journal 20261Risk factors for neonatal sepsis in the intensive care unit: a scoping reviewOBJECTIVE: To map the scientific studies investigating risk factors associated with the occurrence of neonatal sepsis in intensive care units. METHOD: This scoping review followed the JBI Collaboration methodology, with searches conducted in nine databases, two sources of grey literature, and backward searching. Data were collected in September 2024 and updated in January 2025. Data analysis included descriptive statistics and the use of the IraMuTeQ® software. RESULTS: A total of 24 studies were included, with a predominance of publications from Brazil (75%) and Ethiopia (20.8%). The most frequent risk factors were prematurity (f = 20), low birth weight (f = 16), use of invasive devices (f = 15), urinary infection (f = 12), Apgar score (f = 11), and colonization by Streptococcus agalactiae group B (f = 11). CONCLUSION: The scientific literature on risk factors for neonatal sepsis in neonatal intensive care units was mapped, showing that the available evidence addresses multiple maternal, neonatal, and care-related determinants, but is concentrated in few contexts and is predominantly based on observational study designs.Elizangela Ferreira Alves de Paiva; Natália Maria Vieira Pereira-Caldeira; Fábio da Costa Carbogim; Flávia Cristina Rodrigues; Roberta Teixeira Prado; Kelli Borges dos Santos; Hérica Silva Dutra; André Luiz Silva Alvim

Intensive care; Observational study; Sepsis; Neonatal sepsis; Neonatal intensive care unit; Apgar score; Low birth weight; MEDLINE; Medicine; Intensive care medicine; Emergency medicine; Pediatrics; Birth weight; Descriptive statistics; Neonatal infection; Risk factor

2026-01-01https://doi.org/10.1590/1983-1447.2026.20250290.enRevista gaúcha de enfermagem 20261A theoretical investigation of DMT metabolism and the formation of apotential biomarkerMaria Luiza Luiz Marçal; Luiz Antonio Sodre Costa

Tryptamine; Energy metabolism; Biomarker; Catalase; Metabolic pathway; Flavoprotein; Density functional theory; Chemistry; Biochemistry; Computational chemistry; Mechanism of action; Cellular metabolism; Mechanism (biology); Metabolism; Bioenergetics

2026-01-01https://doi.org/10.2139/ssrn.6929027SSRN Electronic Journal 20261High-resolution chemical characterization and bioactivity assessment of Solanum cernuum infusionABSTRACT Ethnopharmacological relevance Solanum cernuum Vell. (Solanaceae), popularly known in Brazil as "panacéia", is widely employed in folk medicine to treat renal and urinary tract disorders. However, despite its ethnopharmacological relevance, the scientific basis for its anti-urolithiatic activity has yet to be established. Aim of the study The present study aims to validate the ethnopharmacological use of S. cernuum by investigating its anti-urolithiatic activity associated with its potential to modulate the inflammatory response. Additionally, a chemical characterization of the infusion was performed. Materials and methods The aqueous leaf infusion was prepared according to traditional use. Anti-urolithiatic activity was assessed in an in vitro human urine model to evaluate calcium oxalate (CaOx) crystal dissolution. Anti-inflammatory potential was investigated via an ex vivo human blood assay stimulated with LPS and calcium ionophore, followed by the assessment of PGE 2 and LTB 4 mediators. The chemical profiling was performed via high-resolution UHPLC-ESI-HRMS in positive ionization mode using a Data-Independent Acquisition (DIA) strategy. Results The infusion significantly reduced CaOx crystal counts in a dose-dependent manner, reaching an 86.6% reduction at the highest concentration tested ( p ≤ 0.05), with efficacy comparable to positive controls. Furthermore, it inhibited the production of PGE 2 (74.8%) and LTB 4 (39.8%), suggesting a dual inhibition of the COX and LOX pathways, showing a more pronounced effect on the COX pathway. Chemical profiling via high-resolution UHPLC-ESI-HRMS led to the annotation of 18 metabolites (level 2, MSI), primarily O -glycosylated flavonoids and other bioactive classes. Conclusions These findings provide scientific support for the traditional use of S. cernuum in renal disorders. The dual modulation of inflammatory mediators, combined with high crystal dissolution capacity, indicates that the infusion holds promising potential as a complementary resource for the management of urolithiasis and constitutes a valuable source of bioactive phytochemicals.Daniele de Oliveira Silva; Paula P.O. Salem; Lara P. D’ M. Costa; Paulo R.S. da Silva; Michael Murgu; Patrı́cia Sartorelli; Danielle F. Dias; Daniela A. Chagas de Paula; RuAngelie Edrada‐Ebel; Marisi G. Soares

Pharmacognosy; Folk medicine; Medicinal plants; Biological activity; Traditional medicine; Chemistry; Biology; Botany

2026-06-12https://doi.org/10.1016/j.jep.2026.121998Journal of Ethnopharmacology 20261Predictive factors for falls and protective effect of group exercise in older adults: a prospective evaluationThis study aimed to assess the predictive value of well-known risk factors for falling in older adults by prospectively evaluating the occurrence of fall episodes on those who joined a group-oriented exercising routine compared to older people without the exercise routine. The balance parameters of 75 older adults was assessed using a force platform along with the history of previous falls, and the presence of diabetes. A subsample (n = 58) performed a group exercising routine 2 to 3 times per week for 1 year. They were followed-up concerning the occurrence of falls episodes. The binary logistic regression analysis retrieved a model including the presence of diabetes (OR = 8.78), previous history of falls (OR = 4.90) and the ML excursion (OR = 0.43) as predictive factors of prospective falls accurately (Sn = 0.948). The exercising routine was protective against future episodes of falls (OR = 4.84). The regression model was able to accurately predict those older adults under the risk of prospective falls. Group exercising was able to protect older people from future falls.Maria de Cássia Macedo; Kariny Realino Ferreira; Ana Clara Leal; Denys Batista Campos; Wrgelles Bordone Pires; Pedro Henrique Berbert Carvalho; Gabriela Lopes Gama; Michelle Almeida Barbosa; Alexandre Carvalho Barbosa

Prospective cohort study; Logistic regression; Falling (accident); Balance (ability); Predictive value; Poison control; Injury prevention; Risk factor; Risk assessment; Medicine; Physical therapy; Physical medicine and rehabilitation; Activities of daily living; Older people; Diabetes mellitus; Falls in older adults; Fear of falling; Predictive value of tests; Excursion

2026-03-10https://doi.org/10.5016/s1980-6574e10248940Motriz Revista de Educação Física 20261Current activity trends and outcomes of hematopoietic cell transplantation: A 2026 report from the Brazilian Registry of Hematopoietic Cell Transplantation in collaboration with the CIBMTR & SBTMOThe development of the Brazilian Registry of Hematopoietic Cell Transplantation (Registro Brasileiro de Transplantes de Células Hematopoieticas), in collaboration with the Center for International Blood and Marrow Transplant Research (CIBMTR), continues to provide a comprehensive assessment of hematopoietic cell transplantation (HCT) activity and outcomes in Brazil. In this study, we report an updated analysis of national transplant activity. Brazilian transplant centers report their data to the CIBMTR using the FormsNet3 platform, and data are returned to the Brazilian Society of Cellular Therapy and Bone Marrow Transplantation (Sociedade Brasileira de Terapia Celular e Transplante de Medula Óssea) through the Data Back to Centers (DBtC) tool. Data from patients who underwent HCT from 2015 to 2025 in Brazilian centers were extracted from the CIBMTR. Descriptive analyses were performed using patient-, disease-, and transplant-related variables, and overall survival was estimated using the Kaplan–Meier method. A total of 15,586 HCTs were included (7,507 autologous and 8,079 allogeneic). For survival analyses, 9,150 patients who underwent a first HCT from 2015 to 2023 were analyzed, with a median follow-up of 35 months. The number of reporting centers increased over time, reaching 51 centers during the study period. Acute leukemias remained the most common indication for allogeneic HCT, while multiple myeloma and lymphomas predominated in autologous HCT. In recent years, mismatched related donors have accounted for the largest proportion of allogeneic transplants. Bone marrow was the main graft source in pediatric patients, whereas peripheral blood predominated in adults. Infections were the most frequent cause of death within the first 100 days after HCT, while primary disease was the leading cause beyond 100 days. Survival patterns varied according to disease characteristics and transplantrelated factors, with lower survival estimates observed in patients transplanted with advanced disease stages. Comparisons with the United States Summary Slides suggest both similarities and differences in transplant activity and outcomes, which should be interpreted with caution given variations in data structure, patient characteristics, and risk stratification.Anderson João Simione; Cinthya Corrêa da Silva; Afonso Celso Vigorito; Antônio Vaz de Macedo; Heliz Regina A. Neves; VADN Varjão; Monique Ammi; Flavia Ferreira da Costa; Adriana Mendes de Quadros Cavilha; Alayne Magalhães T.D. Yamada; Vergílio Antônio Rensi Colturato; Phillip Scheinberg; Samir Nabhan; Décio Lerner; Nelson Hamerschlak; Marcos Paulo Colella; George Maurício Navarro Barros; Alexandre Silvério; Adriana Seber; Simone Ojima Ferreira; Yana Novis; Andreia Ribeiro de Almeida; Vanderson Rocha; Maria Cláudia Rodrigues Moreira; Cláudia Cáceres Astigarraga; Liane Esteves Daudt; Maria Cristina Martins de Almeida Macedo; Ricardo Chiattone; Juliana Folloni Fernandes; Volney Assis Lara Vilela; Rodolfo Daniel de Almeida Soares; Gustavo Machado Teixeira; Celso Arrais‐Rodrigues; Roberto Luiz da Silva; Vaneuza Araújo Moreira Funke; Jayr Schmidt Filho; Vinícius Campos de Molla; João Samuel de Holanda Farias; Ricardo Pasqüini; Carmem Bonfim; Abrahão Elias Hallack Neto; Rodolfo Calixto; João Victor Piccolo Feliciano; Rafael Dezen Gaiolla; Marcelo Capra; Ângelo Atalla; Milton Aranha; Rony Schaffel; Gianne Donato Costa Veloso; Fernando Sergio Blumm Ferreira; Andresa Lima Melo; Simone De Castro Resende Franco; Marcelo Alves Aduan; Andreza Alice Feitosa Ribeiro; Thiago Xavier Carneiro; Wellington Moraes Azevedo; Giancarlo Fatobene; Abel Costa; Marcelo C. Pasquini; Mary E.D. Flowers; Fernando Barroso Duarte

Hematopoietic cell; Multiple myeloma; Transplantation; Bone marrow; Bone transplantation; Hematopoietic stem cell transplantation; Bone marrow transplantation; Medicine; Internal medicine; Oncology; Haematopoiesis; Overall survival; Bone marrow transplant; Lymphoma

2026-06-12https://doi.org/10.46765/2675-374x.2025v7n1e353JOURNAL OF BONE MARROW TRANSPLANTATION AND CELLULAR THERAPY 20261Fatores de risco para sepse neonatal em unidade de terapia intensiva: uma revisão de escopoRESUMO Objetivo: Mapear os estudos científicos que investigam os fatores de risco associados à ocorrência de sepse neonatal em unidades de terapia intensiva. Método: Esta revisão de escopo seguiu a metodologia da JBI Collaboration, com busca em nove bases de dados, duas fontes da literatura cinzenta e busca reversa. Os dados foram coletados em setembro de 2024 e atualizados em janeiro de 2025. A análise dos dados incluiu estatística descritiva e o uso do software IraMuTeQ®. Resultados: Foram incluídos 24 estudos, com predominância de publicações do Brasil (75%) e Etiópia (20,8%). Os fatores de risco mais frequentes foram: prematuridade (f = 20), baixo peso ao nascer (f = 16), uso de dispositivos invasivos (f = 15), infecção urinária (f = 12), baixo escore de Apgar (f = 11), colonização por Streptococcus agalactiae do grupo B (f = 11). Conclusão: Foram mapeados os estudos científicos sobre fatores de risco para sepse neonatal em unidades de terapia intensiva neonatal, demonstrando que a produção disponível aborda múltiplos determinantes maternos, neonatais e assistenciais, porém é concentrada em poucos contextos e baseada majoritariamente em delineamentos observacionais.Elizangela Ferreira Alves de Paiva; Natália Maria Vieira Pereira-Caldeira; Fábio da Costa Carbogim; Flávia Cristina Rodrigues; Roberta Teixeira Prado; Kelli Borges dos Santos; Hérica Silva Dutra; André Luiz Silva Alvim

Neonatal intensive care unit; Neonatal sepsis; Apgar score; Pregnancy; Medicine; Gynecology; Obstetrics

2026-01-01https://doi.org/10.1590/1983-1447.2026.20250290.ptRevista gaúcha de enfermagem 20261Toxoplasmose em gestantes na atenção básicaObjetivo: Estimar a soroprevalência de toxoplasmose em gestantes atendidas na atenção básica e investigar as variáveis sociodemográficas, obstétricas e comportamentais associadas à soropositividade. Método: Estudo transversal, realizado com 145 gestantes saudáveis, de risco habitual, residentes em Juiz de Fora, Minas Gerais, a partir de um questionário estruturado e dados de registros de exames sorológicos. A análise incluiu estatísticas descritivas e inferencial, com nível de significância de 5% e análise multivariada. Resultados: A soroprevalência de toxoplasmose foi de 35,2%. Gestantes soropositivas apresentaram média de idade mais elevada (p < 0,001) e maior número de gestações prévias (p = 0,005). Houve associação com a presença de roedores no domicílio (p < 0,001) e desconhecimento sobre a doença (p = 0,008). Na análise multivariada, a idade materna foi identificada como fator associado (p = 0,012). Conclusão: A maioria das gestantes mostrou-se suscetível à toxoplasmose, reforçando a importância do rastreamento e de ações educativas no pré-natal.Nayara Gonçalves Barbosa; SOFIA MARIA LOPES BRAGA AYRES GARGIULLO; LETÍCIA DA CRUZ SILVA; Marcos Morais Santos Silva; Silvia Regina Marin da Motta; Lúcia Yasuko Izumi Nichiata; Flávia Azevedo Gomes-Sponholz

Toxoplasmosis; Protozoal disease; Pregnancy; Context (archaeology); Medicine; Gynecology

2026-06-01https://doaj.org/article/655a396d3484400883876b69809f69aaDOAJ (DOAJ: Directory of Open Access Journals) 20261O FUTSAL DE SURDOS: NUANCES TÉCNICAS, ESTRATÉGICAS E COMUNICATIVAS NA ORGANIZAÇÃO DO JOGOO futsal de surdos configura-se como uma prática esportiva que ultrapassa a perspectiva da adaptação técnica, constituindo-se como um espaço de produção cultural, interação social e construção identitária da comunidade surda. Este estudo teve como objetivo identificar e descrever as nuances culturais, técnicas e comunicativas presentes nas estratégias visuais e atitudinais utilizadas por atletas surdos na organização do jogo de futsal. Trata-se de uma pesquisa qualitativa, de caráter descritivo e comparativo, desenvolvida por meio de revisão bibliográfica, análise documental de materiais audiovisuais em Libras, observação participante em treinos e jogos, além de entrevistas semiestruturadas realizadas com atletas surdos vinculados à Associação dos Surdos de Goiânia. Os dados foram analisados de forma integrada, articulando contribuições teóricas e evidências empíricas. Os resultados evidenciam que a comunicação visual constitui o principal elemento organizador das ações coletivas, sendo operacionalizada por meio da Libras, de sinais convencionados, expressões corporais e estratégias visuais compartilhadas entre os jogadores. Verificou-se que esses sistemas comunicativos favorecem a coordenação tática, a antecipação de jogadas e a tomada de decisão durante as partidas, além de representarem um diferencial estratégico por serem construídos internamente pelas equipes. Observou-se, ainda, a relevância da articulação entre atletas, treinadores e intérpretes no processo de ensino-aprendizagem esportiva, destacando-se a contribuição de profissionais com conhecimento da cultura surda e das especificidades técnico-táticas da modalidade. Conclui-se que o futsal de surdos apresenta uma organização própria, baseada na comunicação visual e na cultura surda, influenciando a dinâmica do jogo e a construção de sua identidade esportiva.Andréa dos Guimarães de Carvalho; Emerson Filipino Coelho

Identity (music); First language; Meaning (existential); Literacy; Psychology; Humanities

2026-06-13https://doi.org/10.70773/revistatopicos/781236288Revista Tópicos. 20261Behavioral Adaptation to Neck Radio-Collars and Its Relations with Temperament in Two Neotropical Psittacid SpeciesTrack devices can cause behavioral, physical, and physiological adverse effects, with individuals varying in how quickly they adapt to them. We examined behavioral effects of replica radio-collars on two captive psittacid species, Scaly-headed Parrot (17 Pionus maximiliani) and Blue-winged Macaw (12 Primolius maracana), and whether temperament influences adaptation to the device. Five temperament dimensions were identified: Activity, Boldness, Anxiety, Neophobia/Neophilia, and Proximity to Humans. Behavioral observations were conducted in two conditions: baseline (no collars) and with collars. With collars, parrots spent less time in “movement,” “locomotion,” “preening,” “environment interaction,” “feeding,” and “negative social interaction” (p < 0.05), and more time at “rest” and in “inactivity” (p < 0.05) than their baseline measure. “rest” and “inactivity” decreased, while “preening,” “environment interaction,” “feeding,” “movement,” and “locomotion” increased (p < 0.05) as days passed. “Interaction with collar” did not change over time (p > 0.05). Temperament did not influence the adaptation to neck collars (p > 0.05). These behavioral changes may hinder the adaptation and survival of released birds by reducing exploration and increasing stationary behaviors. Such effects can lead to starvation and troublesome social interactions, posing risks for radiotelemetry conservation efforts.Gustavo Nunes de Almeida; Larissa Gomes de Jesus; Maria Eduarda Caçador Branco; Gabriela Ramos; Walef Duarte Vieira; Cristiano Schetini de Azevedo; Aline Cristina Sant’Anna

Temperament; Adaptation (eye); Behavioral syndrome; Habituation; Aggression; Social relation; Persistence (discontinuity); Maladaptation; Psychology; Developmental psychology; Ecology; Captivity; Behavioral pattern

2026-06-14https://doi.org/10.1080/10888705.2026.2681557Journal of Applied Animal Welfare Science 20261IMPLEMENTAÇÃO DE SERVIDOR VOIP EM NUVEM PARA ÁREAS REMOTAS E RURAIS MANTENDO O CALLER IDO objetivo deste trabalho foi propor e validar uma arquitetura de telefonia de Voz sobre Protocolo de Internet capaz de preservar a identificação do chamador em cenários com limitação de infraestrutura de telecomunicações, em áreas remotas e rurais e em situações de uso internacional. A metodologia consistiu na implantação e avaliação comparativa de ambientes de centrais privadas de comutação telefônica locais e em nuvem na plataforma Amazon Web Services, empregando a plataforma proprietária 3CX, o sistema de código aberto FreePBX e a integração com provedoras de voz sobre protocolo de internet, com foco em roteamento, interoperabilidade de protocolo de iniciação de sessão e comportamento da identificação do chamador em chamadas externas via rede telefônica pública comutada. Os resultados indicaram que, nos testes realizados, a solução baseada em FreePBX preservou o número de origem, enquanto a plataforma 3CX apresentou limitações operacionais e de identificação em parte dos cenários avaliados.Augusto Virginio de Castro Paula; Humberto Almeida Guimarães; Amanda de Oliveira Timotheo

The Internet; Internet Protocol; Internet protocol suite; Computer science; Humanities

2026-05-30https://doi.org/10.5281/zenodo.20452797Zenodo (CERN European Organization for Nuclear Research) 20261IMPLEMENTAÇÃO DE SERVIDOR VOIP EM NUVEM PARA ÁREAS REMOTAS E RURAIS MANTENDO O CALLER IDO objetivo deste trabalho foi propor e validar uma arquitetura de telefonia de Voz sobre Protocolo de Internet capaz de preservar a identificação do chamador em cenários com limitação de infraestrutura de telecomunicações, em áreas remotas e rurais e em situações de uso internacional. A metodologia consistiu na implantação e avaliação comparativa de ambientes de centrais privadas de comutação telefônica locais e em nuvem na plataforma Amazon Web Services, empregando a plataforma proprietária 3CX, o sistema de código aberto FreePBX e a integração com provedoras de voz sobre protocolo de internet, com foco em roteamento, interoperabilidade de protocolo de iniciação de sessão e comportamento da identificação do chamador em chamadas externas via rede telefônica pública comutada. Os resultados indicaram que, nos testes realizados, a solução baseada em FreePBX preservou o número de origem, enquanto a plataforma 3CX apresentou limitações operacionais e de identificação em parte dos cenários avaliados.Augusto Virginio de Castro Paula; Humberto Almeida Guimarães; Amanda de Oliveira Timotheo

The Internet; Internet Protocol; Internet protocol suite; Computer science; Humanities

2026-05-30https://doi.org/10.5281/zenodo.20452798Zenodo (CERN European Organization for Nuclear Research) 20261Uma proposta para o desenvolvimento do pensamento computacional na área de Ciências da NaturezaO presente trabalho traz o desenvolvimento de uma proposta sobre a temática energia elétrica e sua aplicação através do software Scratch, com perguntas e explicações. Por meio da interação com o Scratch esperamos que os estudantes adquiram os conhecimentos necessários para entender a importância do uso consciente da energia elétrica e analisar o consumo de energia em sua própria residência. A atividade foi pensada tendo como motivação o intuito de desenvolver algumas habilidades relacionadas ao conhecimento de Ciências para o 8º ano do ensino fundamental, propostas pela Base Nacional Comum Curricular (BNCC) e o desenvolvimento de habilidades do pensamento computacional.Clarice Parreira Senra; Brenda Andress Frank

Context (archaeology); Work (physics); Subject (documents); Philosophy; Humanities; Psychology

2026-06-01https://doaj.org/article/4150d2224cb0456e999624a7145d58a9DOAJ (DOAJ: Directory of Open Access Journals) 20261Patents and Trademarks as Drivers of Regional Economic Resistance in BrazilABSTRACT This study investigates the relationship between innovation and resistance for Brazilian regions. To this end, this work utilizes the economic resistance index alongside data on patent and trademark filings, formal employment, and regional indicators of related and unrelated variety, as well as other structural regional characteristics. Spatial econometrics techniques are used to account for heterogeneity and spatial dependence through the spatial Durbin panel model (SDM) in particular. The findings indicate a positive and significant association between innovation—proxied by trademark statistics—and regional resistance. In contrast, the effect of patent activity on resistance appears to be non‐significant.Rafael Augusto Álvares Mendes; Eduardo Gonçalves; Juliana Gonçalves Taveira

Trademark; Panel data; Resistance (ecology); Index (typography); Work (physics); Intellectual property; Spatial econometrics; Economics; Economic geography; Econometrics; Spatial dependence; Association (psychology)

2026-06-14https://doi.org/10.1111/rode.70177Review of Development Economics 20261Frantz Fanon e o caráter manicomial e racista da Contrarreforma Psiquiátrica brasileiraNo artigo, empreendemos uma análise sobre a Contrarreforma Psiquiátrica em voga no campo da saúde mental, álcool e outras drogas brasileiro, a partir do diálogo com a práxis antimanicomial (e anticolonial) de Frantz Fanon. Desse diálogo - e do diálogo com outros autores que se fundamentam em Fanon -, apreendemos o caráter não só manicomial da Contrarreforma Psiquiátrica, mas também racista, e suas implicações. Para isso, realizamos uma crítica da economia política da Contrarreforma Psiquiátrica brasileira a partir de Fanon, da qual resultou uma análise da centralidade das Comunidades Terapêuticas, o que elas representam e conformam enquanto carro-chefe da Contrarreforma, e como elas têm buscado mistificar sua própria natureza (social) manicomial e racista, ao passo que recrudescem a manicomialização (racista) no campo da saúde mental, álcool e outras drogas, atacando a Reforma Psiquiátrica brasileira e o Sistema Único de Saúde.Pedro Henrique Antunes da Costa; Kíssila Teixeira Mendes

Politics; Field (mathematics); Context (archaeology); Subject (documents); Modernity; Perspective (graphical); Humanities; Sociology

2026-06-15https://doi.org/10.51359/2357-9986.2026.262398Perspectiva Filosófica 20261Simulation of the CYGNO gaseous TPC optical readoutAbstract Gaseous Time Projection Chambers with Optical Readout are sensitive detectors suitable for 3D measurement of low-energy particles (of order 1 keV) and are proposed for detecting rare events such as Dark Matter particle interactions. The CYGNO collaboration is developing such a detector with a high spatial and energy resolution, leveraging an innovative optical readout system. A reliable simulation of the detector response is needed to properly assess the physics reach of this technique and to better understand the performance of the detector in the development phase. Such a simulation cannot entirely rely on existing software packages; indeed, none of the available tools is capable of properly and reliably treating the different phenomena occurring in the detector, from the primary interaction in the gas volume throughout the whole detector response model, including charge transport, light production and propagation, and the response of the optical sensors. In this paper, we present a modeling of the detector response tuned on the CYGNO Optical TPC case; a description of the method is reported together with comparisons with experimental data from the LIME prototype to demonstrate the simulation performances.F. D. Amaro; Rita Antonietti; E. Baracchini; L. Benussi; S. Bianco; C. Capoccia; M. Caponero; Luan Gomes Mattosinhos de Carvalho; G. Cavoto; I.A. Costa; A. Croce; M. D'Astolfo; G. D’imperio; Giorgio Dho; Emanuele Di Marco; J.M.F. dos Santos; D. Fiorina; F. Iacoangeli; Z. Islam; E. Kemp; H.P. Lima; G. Maccarrone; R. D. P. Mano; David José Gaspar Marques; G. Mazzitelli; Pietro Meloni; A. Messina; C. M. B. Monteiro; Rafael Antunes Nóbrega; Igor Fonseca Pains; E. Paoletti; F. Petrucci; Stefano Piacentini; D. Pierluigi; D. Pinci; F. Renga; A Russo; G. Saviano; P. A. O. C. Silva; N.J.C. Spooner; R. Tesauro; S. Tomassini; S. Torelli; D Tozzi

Detector; Time projection chamber; Projection (relational algebra); Software; Simulation software; Volume (thermodynamics); Response time; Physics; Optics; Dark matter; Energy (signal processing); Particle detector; Computer science

2026-06-01https://doi.org/10.1088/1748-0221/21/06/p06024Journal of Instrumentation 20261Evaluating how double skin facade typologies influence daylighting performanceRecent sustainable architecture has increasingly adopted daylight-oriented design strategies. Among these, investigations into double-skin façades (DSF) constitute an emerging area of research, with relatively few studies examining their impact on daylighting performance. Therefore, this study aims to investigate how different DSF structural configurations – multi-storey, box window, corridor, shaft box, tapered, and inverted tapered styles - influence the penetration of natural light in buildings located at two distinct latitudes (0°S and 30°S). Models with configuration variations were developed and simulated using the Ladybug Tools plugin for Grasshopper/Rhino to evaluate daylight performance, particularly seasonal and hourly variations. To numerically verify the differences among the tested cases, statistical analyses using the Kruskal-Wallis and Mann-Whitney tests were employed. The results indicate that daylight performance varies significantly across latitudes and seasons, substantially altering outcomes between locations. Tapered and inverted-tapered styles consistently achieved the highest illuminance levels, while box-window and corridor types demonstrated the lowest efficiency. Although numerical differences were statistically significant, effect sizes were small, indicating a limited impact. Findings suggest that no typology is universally optimal and that context may outweigh geometry in shaping outcomes, offering valuable guidance for architects when selecting DSF typologies to optimize daylight in diverse urban environments.Lívia Costa Gameloni Santiago dos Santos; Beatriz Se Keng Moon; Daniel Conforte da Silva Lemos; Klaus Chaves Alberto; Sabrina Andrade Barbosa

Daylight; Facade; Daylighting; Context (archaeology); GLARE; Visibility; Ceiling (cloud); Architectural engineering; Engineering; Illuminance; Environmental science; Latitude; Computer science

2026-05-11https://doi.org/10.20396/parc.v17i00.8681496PARC Pesquisa em Arquitetura e Construção 20261Mapping Terminology and Domains Related to Spirituality in Oncology: Scoping ReviewJoão Pedro Santos Nascimento; Caique Mariano Pedroso; Alexandre Caroli Rocha; Márcio Ajudarte Lopes; Hercílio Martelli‐Júnior; Horace M. DeLisser; Alan Roger Santos‐Silva

Spirituality; Conceptualization; Existentialism; Terminology; Thematic analysis; Coping (psychology); Psychosocial; Meaning (existential); Construct (python library); Psychology; Qualitative research; Faith; Theme (computing); Social psychology; Epistemology; Schema (genetic algorithms); Sociology; Psychotherapist

2026-06-15https://doi.org/10.21203/rs.3.rs-8824077/v1Research Square 20261Extensao universitaria voltada a atencao da crianca e do adolescente com Hipomineralizacao Molar-Incisivo (HMI)A extensão universitária é um processo potencialmente transformador, que deve estar articulada de forma indissociável ao ensino e à pesquisa. Este artigo tem como objetivo apresentar a experiência de um projeto de extensão de uma Faculdade de Odontologia no estado do Rio de Janeiro, ao longo de 12 anos. O projeto foi marcado, desde seu início, pela troca de vivências de discentes de graduação e pós-graduação; pela definição das atividades do projeto como cenário de prática assistencial e de pesquisa do Programa de Pós-graduação stricto sensu na área de concentração em Odontopediatria. A partir disso, a produção acadêmica foi alinhada às atividades de ensino e extensão realizadas, promovendo uma formação profissional diferenciada aos discentes e a disseminação do conhecimento científico ao público acadêmico e leigo. Palavras-chave: Comunicação e divulgação Científica; Ensino; Serviços de saúde bucal. University extension focused on caring for children and adolescents with Molar-Incisor Hypomineralization (MIH) University extension is a transformative process that must be linked to teaching and research. This article presents the experience of a 12-year extension project at a dental school in Rio de Janeiro, Brazil. Since its inception, the project has been characterized by an exchange of experiences between undergraduate and postgraduate students, as well as by defining the project’s activities as a setting for practical care and research within the stricto sensu postgraduate program in Pediatric Dentistry. From this perspective, academic production aligned with teaching and extension activities, promoting differentiated professional development for students and disseminating scientific knowledge to academic and general public. Keywords: Communication and diffusion; Teaching; Dental health services.Roberta Costa Jorge; Gabriela Caldeira Andrade Americano; Bianca Mattos dos Santos Guerra; Thamires Pereira de Souza Teixeira; Vera Mendes Soviero

Transformative learning; Higher education; Sociology of scientific knowledge; Subject (documents); Qualitative research; Focus group; Work (physics); Pedagogy; Psychology; Sociology; Medical education; Nursing; Humanities

2026-06-03https://doi.org/10.12957/interag.2026.93237Interagir pensando a extensão 20261A lab-made stencil-printed electrode with silver nanoparticle-modified graphite for the determination of the antibiotic sulfamethoxazole in different real samples). Furthermore, the method showed good precision (RSD < 3.7%) and accuracy with recoveries ranging from 92 to 107% for spiked river water, honey and synthetic urine samples. The proposed device showed robust stability over time and excellent selectivity in the presence of other antibiotics and components of the sample matrix. Therefore, the proposed sensor is a promising, simple, cost-effective and efficient alternative for electroanalysis of emerging contaminants.Gabriele Santos De Carvalho; Anderson da Silva Pereira; Lucila Aranguina Chiquillan; Wallace Burger Veríssimo de Oliveira; Renato Camargo Matos; Willyam R.P. Barros; Thalles Pedrosa Pedrosa Lisboa

Contamination; Graphite; Electrode; Sulfamethoxazole; Antibiotics; Environmental chemistry; Soil contamination; Chemistry; Carbon fibers; Materials science

2026-01-01https://doi.org/10.1039/d6ay00455eAnalytical Methods 20261Detecção de vulnerabilidades em bytecodes de contratos inteligentes no Ethereum via embeddings do CodeBERTO Ethereum é uma plataforma de criptomoedas que permite a execução de contratos inteligentes, programas autônomos que operam em uma rede descentralizada. As vulnerabilidades nesses contratos representam grandes riscos financeiros e de segurança nos ecossistemas blockchain, motivando a automatização do processo de detectá-las. Este trabalho estuda a detecção de vulnerabilidades em contratos inteligentes Ethereum usando embeddings derivados de bytecode. Embeddings são representações vetoriais geradas por modelos de linguagem, que capturam as características estruturais de texto. Essas representações foram usadas como entrada para os algoritmos de regressão logística, árvore de decisão e floresta aleatória, com o fim de detectar quais contratos possuem vulnerabilidades. Os resultados mostram que os embeddings contêm informações úteis para distinguir contratos vulneráveis de não vulneráveis. O estudo também constata que a alteração da distribuição original dos dados durante o treinamento afeta significativamente o desempenho, destacando a sensibilidade das abordagens baseadas em embeddings às estratégias de amostragem.Pedro Henrique F. S. Oliveira; Heder S. Bernardino; Saulo Moraes Villela; Edelberto Franco Silva; Jairo Francisco de Souza; Alex B. Vieira

Field (mathematics); Term (time); State (computer science); Work (physics); Computer science

2026-05-25https://doi.org/10.5753/sbrc.2026.19804 20261Dados revisão sistematica githubKetleen Anne Faria

2026-06-16https://doi.org/10.5281/zenodo.20710704Zenodo (CERN European Organization for Nuclear Research)

20261A Two-Step Decomposition Approach for Stochastic Mid-Term Power Generation Planning With Disjunctive Constraints for ReservoirsPower generation planning in large-scale hydrothermal systems faces significant challenges due to uncertainty in water inflows, temporal coupling in the operation of large reservoirs, and complex cascade arrangements. Traditional decomposition techniques such as Dual Dynamic Programming (DDP) and Stochastic Dual Dynamic Programming (SDDP) are widely used, but struggle to accurately model disjunctive (conditional) constraints that require integer variables, leading to non-convexities and suboptimal solutions. Those constraints appear in operating rules for storage and discharge decisions of some hydro plants, such as minimum discharge requirements to maintain river flow, which are conditioned on reservoir storage levels along the cascade. To tackle this real-world problem, this work proposes a novel two-step decomposition methodology that combines standard Benders or Strengthened Benders approaches with a simplified binary variable representation for reservoir volumes to address disjunctive constraints. This approach enables the efficient application of Stochastic Dynamic Dual Integer Programming (SDDiP) without the need for binary expansion, thereby improving solution quality in reasonable computational performance. The method is validated on a realistic case study based on the Brazilian power system, demonstrating a reduction in the optimality gap corresponding to approximately <inline-formula> <tex-math notation="LaTeX">${\$}400$ </tex-math></inline-formula> million in operational cost savings, along with improved operational strategies compared to conventional approaches. The results highlight the importance of accurate modeling of conditional hydraulic constraints and the potential for scalable and computationally efficient planning approaches in hydro-dominated systems.Lílian C. Brandão; André Luiz Diniz; Bruno H. Dias

Decomposition; Electricity generation; Stochastic process; Power (physics); Production (economics); Electric power system; Production planning; Benders' decomposition; Computer science; Mathematical optimization

2026-01-01https://doi.org/10.1109/access.2026.3704030IEEE Access 20261Detecção de Oportunidades de Sanduíche MEV via Grafo de Fluxo de Controle de Contratos InteligentesAs Finanças Descentralizadas (DeFi) têm transformado o ecossistema financeiro ao permitir negociações sem intermediários, mas também introduz novos vetores de ataque. Estratégias do tipo Sanduíche MEV exploram configurações inseguras de derrapagem de preço em trocas descentralizadas, gerando perdas financeiras significativas aos usuários. Enquanto as mitigações atuais focam predominantemente na camada de rede, há uma lacuna em ferramentas preventivas de auditoria de código. Este trabalho propõe uma abordagem de análise estática baseada em Gráfico de Fluxo de Controle para detectar a ausência de proteções de limite de preço em contratos inteligentes. Nossa metodologia rastreia o código de contratos inteligentes Solidity da rede Ethereum, visando identificar parâmetros inseguros ou não validados pelo usuário. Resultados preliminares demonstram que o detector alcançou uma acurácia de 78,9% em protocolos DeFi reais, contribuindo para a segurança preventiva em redes Blockchain.Josué N. Campos; Aline C.S. Silva; Cleidimar L. dos Passos; Glauber D. Gonçalves; Alex B. Vieira; José Augusto M. Nacif

Work (physics); Slipping; Christian ministry; Humanities; Physics; Computer science

2026-05-25https://doi.org/10.5753/sbrc.2026.19389 20261NOAH: Protocolo Hibrido e Adaptativo de Codificação de Rede para Comunicação por Luz VisívelCom o avanço da tecnologia e as crescentes demandas das redes de computadores, a Comunicação por Luz Visível (VLC) ganhou destaque devido às suas capacidades de transmissão. No entanto, como o espectro da luz visível pode sofrer interferências externas, essa tecnologia apresenta alta perda de pacotes, prejudicando a transmissão. Este artigo apresenta o NOAH (Network cOding Adaptive Hybrid protocol), alcançando ganhos de aproximadamente 23% na redução da taxa de perda de pacotes em relação ao mecanismo ARQ. O ARQ, por sua vez, apresentou ganhos de até 27% quando comparado ao esquema Best-Effort. Além disso, é apresentado um modelo de simulação mais realista para o módulo de VLC do ns-3.Douglas D. M. Silva; Vitor A. S. Carvalho; Kristtopher K. Coelho; Matheus Nogueira Moreira; Marcos A. M. Vieira; Alex B. Vieira; Luiz F. M. Vieira; José Augusto Nacif

Context (archaeology); Order (exchange); Work (physics); Humanities; Philosophy; Computer science

2026-05-25https://doi.org/10.5753/sbrc.2026.19277 20261Decoder Dependence in Surface‐Code Threshold Estimation Under Digitized Hybrid Continuous‐Variable and Discrete NoiseABSTRACT Surface‐code threshold estimates depend on the inference pipeline, including decoder and estimator choices. We compare decoders within a single LiDMaS+ workflow under Pauli‐reference and digitized hybrid continuous‐variable/discrete sweeps. In the Pauli‐reference mode, the matching‐style backend outperforms Union‐Find and yields crossing median (bootstrap interval [0.0415,0.0572]) and collapse fit (). For the hybrid mode, a dense transition‐window sweep at uses with step 0.01 and 3000 trials per point. After the initial exact‐zero plateau is excluded from crossing localization, the matching‐style backend gives interior crossing estimates for and for ; the latter lies in a low‐LER region and remains estimator‐sensitive. A targeted extension shows larger Union‐Find LER at moderate‐to‐high and matching‐fallback rates up to 0.747 at . In a neural‐guidance sensitivity sweep, full learned reweighting reduces the sampled mean LER from 0.1773 to 0.1663 over . These results show that estimator resolution and backend fallback diagnostics are part of an auditable decoder comparison.Dennis Delali Kwesi Wayo; Chinonso Onah; Leonardo Goliatt; Sven Groppe

Estimator; Sensitivity (control systems); Noise (video); Interval (graph theory); Inference; Minification; Estimation theory; Signal-to-noise ratio (imaging); Algorithm; Computer science; Maximum likelihood; Mathematics; Mode (computer interface); Workflow

2026-06-01https://doi.org/10.1002/prop.70124Fortschritte der Physik 20261A Card Game for Architectural Patterns EducationSoftware Architecture education presents significant pedagogical challenges due to its abstraction. Existing approaches, such as educational games, often fail to address the skill of identifying architectural patterns from narrative-based problems. In this context, we propose Architectural Stories, a non-digital card game designed to fill this gap. The mechanics require players to investigate scenarios and deduce a solution by linking a problem diagnosis to a specific architectural pattern. To evaluate its effectiveness, we conducted a study with 34 undergraduate students using the MEEGA+ instrument. The results were positive, indicating that the game is usable, engaging, motivating, and an effective tool for understanding architectural patterns.Maria Clara Ribeiro de Menezes; Pedro Henrique Dias Valle; Alessandreia Marta de Oliveira

Architectural pattern; Architecture; Software; Architectural design; Game Developer; Software architecture; Game testing; Computer software; Computer science; Software engineering; Human–computer interaction; Multimedia; Engineering; Architectural engineering; Game based learning

2026-05-04https://doi.org/10.5753/educomp.2026.18652 20261REPRODUCTIVE HEALTH IN DAIRY COWS: MICROBIOLOGICAL INVESTIGATION OF ENDOMETRITIS IN COMPOST BARN SYSTEMSPedro Felipe Rodrigues e Oliveira; Alessandro de Sá Guimarães; Marcilene Daniel Damasceno; Maysa Serpa Gonçalves; Milena Carvalho Coelho; Andréa Micke Moreno; Júlio Sílvio de Sousa Bueno Filho; Giovani Festa Paludo; Guilherme N. De Souza; Elaine Maria Seles Dorneles; Bruno Campos de Carvalho

Endometritis; Streptococcus uberis; Metritis; Barn; Infertility; Subclinical infection; Streptococcus dysgalactiae; Herd; Biology; Animal science; Veterinary medicine; Postpartum period; Physiology; Reproductive health; Dairy cattle; Retained placenta; Uterus; Vaginal discharge

2026-01-01https://doi.org/10.2139/ssrn.6952404SSRN Electronic Journal 20261Activity performance and participation of children and adolescents with cerebral palsy: A cross‐sectional multicentre study in BrazilAIM: To evaluate direct, indirect, mediating, and moderating effects on the activity performance and participation of children and adolescents with cerebral palsy (CP), from the perspective of the International Classification of Functioning, Disability and Health (ICF). METHOD: This cross-sectional study included 190 Brazilian children and adolescents, with a median age of 7 years. The Pediatric Evaluation of Disability Inventory - Computer Adaptive Test was used to evaluate activity performance (daily activities, mobility, social/cognitive domains) and participation (responsibility domain). Data on Gross Motor Function Classification System (GMFCS) level, age, anatomical distribution, and use of assistive technology for mobility (environmental factors) were collected by an online form and included in the structural equation modelling using path analysis. RESULTS: A direct effect was identified from the GMFCS, age, anatomical distribution, and assistive technology for mobility. Anatomical distribution indirectly influenced all domains, with GMFCS level mediating this relationship. The moderating effect of assistive technology for mobility in the GMFCS levels was observed, improving the performance in daily activities, mobility, social/cognitive functioning, and responsibility. INTERPRETATION: This study contributes to the understanding of the complexity of factors influencing the activity performance and participation of children and adolescents with CP, emphasizing the need for comprehensive assessments aligned with the ICF framework.Déborah Ebert Fontes; Kênnea Martins Almeida Ayupe; Paula Silva de Carvalho Chagas; Robert J. Palisano; Hércules Ribeiro Leite; Ana Cristina Resende Camargos

Cerebral palsy; International Classification of Functioning, Disability and Health; Gross Motor Function Classification System; Assistive technology; Perspective (graphical); Test (biology); Structural equation modeling; Gross motor skill; Physical medicine and rehabilitation; Psychology; Physical therapy; Activities of daily living; Computerized adaptive testing; Developmental psychology; Medicine; Path analysis (statistics); Motor skill; Gerontology

2026-06-15https://doi.org/10.1111/dmcn.70335Developmental Medicine & Child Neurology 20261Response to the letter to the editor regarding “Clinical decision-making regarding histopathologic submission of tooth-associated lesional tissue”Denis Talis Reis; Iara Vieira Ferreira; Eva Beatriz Freitas Braga; Francielle Silvestre Verner; Sibele Nascimento de AQUINO

Letter to the editor; MEDLINE; Anatomical pathology; Medicine; General surgery; Dermatology

2026-06-01https://doi.org/10.1016/j.oooo.2026.06.005Oral Surgery Oral Medicine Oral Pathology and Oral Radiology 20261Processo Transexualizador no Brasil em 2026O projeto Processo Transexualizador no Brasil em 2026 busca mapear as diferentes configurações dos estabelecimentos de saúde direcionados a população trans e travesti no Brasil a partir dos anos 2010. O estudo localizou 189 estabelecimentos fornecendo algum tipo de atendimento direcionado a população trans e travesti, entre esses, 171 oferecem serviços ambulatoriais, com a inclusão de hormonioterapia, 28 estabelecimentos habilitados pelo Ministério da Saúde, nas modalidades Ambulatorial e/ou Hospitalar, onde 14 desses estabelecimentos são autorizados para procedimentos cirúrgicos.Pedro Figueiredo Nolasco; Marco José de Oliveira Duarte

Context (archaeology); Coin flipping; Sign (mathematics); Humanities

2026-06-14https://doi.org/10.7910/dvn/lnqrtoHarvard Dataverse 20261Paciente Empoderado: construção e validação de aplicativo para a prevenção de eventos adversos em saúdeBackground and Objectives: Patient empowerment has become a key strategy for promoting patient safety and preventing incidents and adverse events in healthcare services. In the Brazilian context, there is a lack of validated mobile technologies aimed at this purpose. Therefore, this study aimed to develop and validate a mobile application designed to empower patients in the prevention of incidents and adverse health events. Methods: This study was conducted in two stages: a scoping review and a methodological study focused on technological production. The application was developed for Android® and iOS® platforms, following the Dick and Carey instructional design model, and validated in terms of content, appearance, semantics, and usability by expert judges and patients. Results: The application achieved a Content Validity Index above 0.90, demonstrated high usability, and showed strong user acceptance, with mean scores above 4.0 in the heuristic evaluation. Conclusion: The application proved to be valid, innovative, and promising for patient empowerment and the prevention of adverse events in healthcare services.Évilin Martins de Assis; Julya Kelly Ferreira; Joao Gabriel Santos; Júlia Pimentel Clemente; Delma Conceição Soares da Silva; André Luiz Silva Alvim

Usability; Patient Empowerment; Empowerment; Patient safety; Adverse effect; Health care; Mobile technology; Digital health; Medicine; Nursing; Medical emergency; Mobile device; MEDLINE; Patient satisfaction

2026-06-14https://doi.org/10.17058/reci.v16i.21095Revista de Epidemiologia e Controle de Infecção 20261Enhancing the Mutation Testing Education through a Gamified EnvironmentSoftware testing plays a central role in quality assurance. However, challenges remain in teaching advanced concepts, such as mutation testing. The literature suggests that traditional methods do not always effectively support student engagement, motivating the adoption of active learning approaches. We present GAMutation, a gamified environment developed with the Construct 2 to support the teaching of mutation testing. To evaluate its usability, a heuristic evaluation was conducted with undergraduate students. The results indicated positive perceptions and highlighted aspects of the interface and interaction that may guide future improvements. The study reinforces the potential of gamification as a complementary strategy in software testing education.Dário Darienço; Alessandreia Marta de Oliveira; Ricardo Vilela; Williamson Silva; Maurício Massaru Arimoto; Pedro Henrique Valle

Construct (python library); Quality (philosophy); Interface (matter); Software testing; Software; Mutation; Perception; Computer science; Knowledge management; Mutation testing; Human–computer interaction; Software engineering; Heuristic; Test (biology)

2026-05-04https://doi.org/10.5753/educomp.2026.18661 20261A Brazilian Perspective on Quality and Sustainability Aspects of Open Educational Resources in Computing EducationUniversities are increasingly adopting new technologies to enhance teaching, with Open Educational Resources (OER) playing a central role in expanding access to high-quality learning materials. However, although many OER are produced, these resources are underutilized, become outdated, or lack design elements that ensure long-term sustainability. This work identifies essential characteristics that support the effective and lasting integration of OER into educational practice. We conducted a survey and semi-structured interviews with Computing instructors who develop or use OER. The findings highlight key attributes that support OER reuse, maintenance, and longevity, underscoring the need for further research to inform sustainable OER design and development.Ágata Meireles Carvalho; Williamson Silva; Alessandreia Marta de Oliveira; Pedro Henrique Dias Valle

Open educational resources; Sustainability; Perspective (graphical); Work (physics); Quality (philosophy); Key (lock); Sustainable development; Knowledge management; Business; Educational resources; Process management; Educational technology; Engineering ethics; Open education

2026-05-04https://doi.org/10.5753/educomp.2026.18662 20261Uma Arquitetura Descentralizada para Aprendizado Federado Baseada em Blockchain: Um Estudo de Caso sobre Mecanismos de ConsensoO Aprendizado Federado tem se consolidado como alternativa aos modelos centralizados ao mitigar riscos de privacidade, enquanto sua integração com Blockchain busca eliminar pontos únicos de falha e aumentar a confiança no treinamento distribuído. Contudo, experimentos reais são onerosos e arquiteturas inadequadas podem introduzir ineficiências e vulnerabilidades com impactos significativos em desempenho e segurança. Este trabalho avalia, por meio de simulações no framework FLEX, o impacto dos mecanismos de consenso Proof-of-Work (PoW) e Proof-of-Federated-Learning (PoFL) em sistemas de Aprendizado Federado baseados em Blockchain. Os resultados indicam que o PoFL, orientado ao desempenho do modelo, alcança acurácia superior a 80%, acelera a convergência e reduz o número de rodadas de treinamento, à custa de maior custo computacional por rodada e menor throughput quando comparado ao PoW. Por sua vez, o PoW apresenta validação mais rápida da rede, porém resulta em um processo de aprendizado mais lento e instável. A análise evidencia os trade-offs entre qualidade do modelo, estabilidade do treinamento e custos operacionais.Francinaldo Barbosa; Luis Guilherme Silva; Iure Fé; Israel Cardoso; Alex Vieira; Geraldo P. Rocha Filho; Francisco Airton Silva

Quality (philosophy); Robustness (evolution); Process (computing); Generalized additive model; Computer science

2026-05-25https://doi.org/10.5753/sbrc.2026.19318 20261Author Correction: Global burden of amphetamine, cannabis, cocaine and opioid use in 204 countries, 1990–2023: a Global Burden of Disease StudyJiseung Kang; Hyeon Jin Kim; Min Seo Kim; GBD 2023 Substance Use Collaborators; Jae Il Shin; Hasan Aalruz; Yohannes Abate; Nasir Abbas; Mohammadreza Abbasian; Samar Abd ElHafeez; Michael Abdelmasseh; Arash Abdollahi; Mohammad Abdollahi; Meriem Abdoun; Roberto Ariel Abeldaño Zúñiga; Olugbenga Olusola Abiodun; Olumide Abiodun; Richard Gyan Aboagye; Dariush Abtahi; Ibrahim Jatau Abubakar; Bilyaminu Abubakar; Eman Abu-Gharbieh; Salahdein Aburuz; Ahmed Abu-Zaid; Mesafint Molla Adane; Isaac Yeboah Addo; Olumide Thomas Adeleke; Habeeb Omoponle Adewuyi; Temitayo Esther Adeyeoluwa; Kishor Adhikari; Muhammad Sohail Afzal; Saira Afzal; Williams Agyemang‐Duah; Aqeel Ahmad; Sajjad Ahmad; Danish Ahmad; Ali Ahmadi; Syed Anees Ahmed; Haroon Ahmed; Muktar Beshir Ahmed; Ayman Ahmed; Mehrunnisha Sharif Ahmed; Mohammed Ahmed Al-kaif; Muaaz Alajlani; Rasmieh Al‐Amer; Mohammed Albashtawy; Wafa A. Aldhaleei; Abdelazeem M. Algammal; Fadwa Naji Alhalaiqa; Mohammed Usman Ali; Liaqat Ali; Syed Shujait Ali; Mohammad Daud Ali; Sheikh Mohammad Alif; Samah W. Al-Jabi; Ahmad Alrawashdeh; Rami H. Al-Rifai; Sahel Majed Alrousan; Najim Alshahrani; Ala’a B. Al‐Tammemi; Yazan Al Thaher; Nelson Alvis-Guzmán; Mohammad Al-Wardat; Yaser Mohammed Al-Worafi; Hany Aly; Karem H. Alzoubi; Walid A. Al-Zyoud; Sohrab Amiri; Mohammad Amrollahi‐Sharifabadi; Ganiyu Adeniyi Amusa; Abhishek Anil; Carl Abelardo T. Antonio; Catherine M Antony; Iyadunni Adesola Anuoluwa; Boluwatife Stephen Anuoluwa; Jalal Arabloo; A M Araújo; I Gusti Agung Ketut Sri Ardani; Demelash Areda; Benedetta Armocida; Mahwish Arooj; Anton A Artamonov; Mohammad Asghari-Jafarabadi; Tahira Ashraf; Muhammad Shahzad Aslam; Seyyed Shamsadin Athari; Alok Atreya; Avinash Aujayeb; Lemessa Assefa A Ayana; Ahmed Y. Azzam; Nayereh Baghcheghi; Nasser Bagheri; Razieh Bahreini; Ruhai Bai; Atif Amin Baig; Maciej Banach; Mehmet Firat Baran; Mainak Bardhan; Hiba Jawdat Barqawiil; Amadou Barrow

Burden of disease; Disease burden; Disease; Substance use; Burden of proof; Opioid; Medicine; Intensive care medicine; Opioid-Related Disorders; Psychiatry; MEDLINE

2026-06-16https://doi.org/10.1038/s41591-026-04513-4Nature Medicine 20261Dados revisão sistematica githubKetleen Anne Faria

2026-06-16https://doi.org/10.5281/zenodo.20710705Zenodo (CERN European Organization for Nuclear Research)

20261Aura e remasterizaçãoAlan Marques de Pinho; Arthur Vasconcelos da Costa

2026-06-16https://doi.org/10.4025/29a.v6.i10.7957629 de abril Revista de História

20261Revisiting the typification of Lippia riedeliana (Verbenaceae)Abstract The present study revisits the previously selected lectotype for Lippia riedeliana , which was designated in a proposal to reject this name. According to our reinterpretation, this typification was based on non‐original material and, therefore, must be superseded. The holotype is at LE, and this specimen must be cited accordingly.Pedro Henrique Cardoso; Fátima Regina Gonçalves Salimena; Jefferson Prado

Typification; Holotype; Nomenclature; Lippia; Type (biology); Geography

2026-06-01https://doi.org/10.1002/tax.70173Taxon 20261ESTRATÉGIA DE DIVERSIFICAÇÃO DE RECEITAS: UM ESTUDO NO SETOR VAREJISTA BRASILEIROResumo O presente trabalho tem por finalidade estudar como a diversificação de receita proveniente de canais de venda impactam na performance financeira de grandes empresas varejistas no Brasil. Para tanto, foi realizado um estudo de casos múltiplos envolvendo três grandes empresas varejistas brasileiras. Os dados foram coletados a partir de duas fontes documentais principais, os relatórios anuais publicados pelas empresas e os dados das mesmas, divulgados pela B3 em seu site. A análise dos dados foi realizada a partir de três indicadores principais: o Índice Herfindahl Hirschman (HHI), a Margem Líquida (ML) e o preço médio anual das ações de cada uma das companhias. Foi identificado que empresas que investem na diversificação de canais possuem melhor performance financeira em diferentes contextos econômicos do que aquelas dependentes de apenas uma menor quantidade de canais de venda, com destaque para o grande desafio de rentabilizar o formato online. O estudo contribui para o entendimento da relevância da diversificação de receita proveniente de canais de vendas nas empresas varejistas e quais caminhos possuem os maiores desafios para as companhias do setor. Palavras-chave: Canais de venda; Performance financeira; Varejo.Vinícius Motta Lima; Leonardo Lemos da Silveira Santos; Alyce Cardoso Campos; Rita de Cássia Leal Campos; Gustavo Nunes Maciel

Work (physics); Resource (disambiguation); Data collection; Profit (economics); Business; Economics; Marketing

2026-06-16https://doi.org/10.5281/zenodo.20720405Zenodo (CERN European Organization for Nuclear Research) 20261Tem um Elefante na Minha Sala de Aula! Barreiras de Gênero e Inclusão Sob uma Perspectiva Interseccional em Cursos de ComputaçãoNos cursos de Computação, persistem desigualdades que afetam desproporcionalmente mulheres cis e trans, agravadas por raça, maternidade e condição socioeconômica. Essas barreiras se manifestam em preconceitos, microviolências, exclusão acadêmica e falta de apoio institucional, comprometendo a permanência das estudantes. Este estudo busca compreender como esses desafios são vivenciados e quais estratégias de resistência são adotadas. Para isso, foram realizadas entrevistas semiestruturadas com 15 participantes, as quais foram analisadas por meio de uma abordagem temática interseccional. Os resultados revelam discriminações, lacunas institucionais e táticas de enfrentamento, o que aponta para a necessidade de políticas de equidade, acolhimento e formação docente.Pietra Soares; Maria Luiza Rocha; Alessandreia Marta de Oliveira; Pedro Henrique Valle; Williamson Silva

Subject (documents); Qualitative research; Order (exchange); Exploratory research; Action (physics); Humanities; Philosophy; Sociology; Political science

2026-05-04https://doi.org/10.5753/educomp.2026.18594 20261Optical tongue based on Mach–Zehnder interferometers and automated machine learning for spoilage microorganisms assessment in ricotta cheeseEnsuring the microbiological quality of fresh cheeses remains a critical challenge for the dairy industry due to the susceptibility of high-moisture products to spoilage microorganisms and the limited suitability of conventional analytical methods for rapid monitoring. This work proposes an optical sensing approach based on Mach–Zehnder interferometers implemented with micro-tapered long-period fiber gratings (MT-LPFGs) as an electronic tongue for assessing microbiological contamination in ricotta cheese. The sensing principle relies on monitoring variations in the surrounding refractive index (RI) induced by physicochemical changes resulting from microbial metabolic activity, which modulate the interferometric phase response and the subsequent spectral transmission profile. Samples were prepared with controlled concentrations of Staphylococcus spp. as a target indicator of microbial spoilage, obtained through serial dilutions. The framework predicts contamination levels ( CFU/g) by processing these complex, nonlinear spectral features using an Automated Machine Learning (AutoML) framework. Multiple learning algorithms, including neural networks, ensemble-based methods, and instance-based models, were systematically trained and evaluated using complementary error and correlation metrics. A multi-objective Pareto-based analysis was employed to jointly consider predictive accuracy and computational efficiency. The results demonstrate that the proposed framework enables accurate estimation of contamination levels, with the NeuralNetTorch model achieving a correlation coefficient ( ) of 0.976 and a limit of detection (LOD) of 1.62 CFU/g. Overall, the combination of interferometric fiber-optic sensing and AutoML offers a rapid, non-destructive, and robust solution for microbiological quality monitoring of fresh cheeses, with strong potential for real-time industrial applications.Renato Luiz Faraco Filho; Deivid Campos; Lizandra Rezende; Felipe Oliveira Barino; Marcus Vinicius Souza; Alexandre Bessa dos Santos

Food spoilage; Microorganism; Astronomical interferometer; Pattern recognition (psychology); Training set; Artificial intelligence; Machine learning; Computer science; Food science; Engineering

2026-06-16https://doi.org/10.1016/j.sna.2026.118109Sensors and Actuators A Physical 20261ESTRATÉGIA DE DIVERSIFICAÇÃO DE RECEITAS: UM ESTUDO NO SETOR VAREJISTA BRASILEIROResumo O presente trabalho tem por finalidade estudar como a diversificação de receita proveniente de canais de venda impactam na performance financeira de grandes empresas varejistas no Brasil. Para tanto, foi realizado um estudo de casos múltiplos envolvendo três grandes empresas varejistas brasileiras. Os dados foram coletados a partir de duas fontes documentais principais, os relatórios anuais publicados pelas empresas e os dados das mesmas, divulgados pela B3 em seu site. A análise dos dados foi realizada a partir de três indicadores principais: o Índice Herfindahl Hirschman (HHI), a Margem Líquida (ML) e o preço médio anual das ações de cada uma das companhias. Foi identificado que empresas que investem na diversificação de canais possuem melhor performance financeira em diferentes contextos econômicos do que aquelas dependentes de apenas uma menor quantidade de canais de venda, com destaque para o grande desafio de rentabilizar o formato online. O estudo contribui para o entendimento da relevância da diversificação de receita proveniente de canais de vendas nas empresas varejistas e quais caminhos possuem os maiores desafios para as companhias do setor. Palavras-chave: Canais de venda; Performance financeira; Varejo.Vinícius Motta Lima; Leonardo Lemos da Silveira Santos; Alyce Cardoso Campos; Rita de Cássia Leal Campos; Gustavo Nunes Maciel

Work (physics); Resource (disambiguation); Data collection; Profit (economics); Business; Economics; Marketing

2026-06-16https://doi.org/10.5281/zenodo.20720406Zenodo (CERN European Organization for Nuclear Research) 20261Carta PerezhivaniyThis study analyzes the dialogue between geographical memories and children's cartographic records, investigating how space—an intrinsic dimension of existence—is signified by children in an urban center in Rio de Janeir, and Quilombo - Minas Gerais and by a migrant child (Harraga) in Italy. The theoretical framework is anchored in the concept of spatial lived experience (prostranstvennoe perejivanie), derived from Vygotsky's theory, which understands space as an affect-intellect unit. Methodologically, the research utilizes conversation as a central strategy, valuing oral narratives and children's protagonism to break away from rigid technical categories. The investigation culminates in the creation of “Experiential Maps”, representations that transcend physical metrics to record the intensities, affections, and meanings of daily life. The results reveal that children's cartography possesses its own logic, constituting a fundamental language of spatial authorship that distinguishes the child's perspective from that of the adult.Jader Janer Moreira Lopes; Flávio Santiago; Reinaldo José de Lima

Perspective (graphical); Dimension (graph theory); Narrative; Space (punctuation); Conversation; Lived experience; Agency (philosophy); Sociology; Linguistics; Epistemology; Geography; Center (category theory); Interpretation (philosophy); Cartography; Urban space; Physical space

2026-06-17https://doi.org/10.4018/979-8-3373-8541-9.ch003 20261Reshaping urban space: evidence of a TOD policy in Curitiba, BrazilLuiz Pedro Couto Santos Silva; Alexandre Alves Porsse

Zoning; Urban planning; Population; Intervention (counseling); Sustainable development; Key (lock); Transit-oriented development; Incentive; Business; Economic growth; Geography

2026-01-01https://doi.org/10.2139/ssrn.6960029SSRN Electronic Journal 20261Use of recombinant gonadotropins in goat MOET programsShara D.E. Silva; Lucas M. Figueira; Mariana García Kako Rodriguez; Maria Eduarda A. Teixeira; Bruna Waddington de Freitas; R. Batista; Felipe Zandonadi Brandão; Joanna Maria Gonçalves Souza‐Fabjan; Luiz Gustavo B. Siqueira; J. F. da Fonseca

Recombinant DNA; Receptor; Bovine somatotropin; Biological activity; Chemistry; Molecular biology; Biochemistry

2026-06-17https://doi.org/10.1016/j.anireprosci.2026.108273Animal Reproduction Science 20261Quantifying and Comparing Training Load Metrics in Cycling: A Methodology ReviewAccurate monitoring of training load is vital for optimizing performance and reducing the risk of maladaptation, injury, or illness in cyclists. Training load quantification also informs nutrition planning, as daily energy and macronutrient requirements are often adjusted based on exercise demands. Although a range of metrics is available, from power output-based measures to heart rate and perceived exertion indicators, students and early-career practitioners often encounter difficulties in selecting, calculating, and interpreting these indices. This methodology review outlines how to compute three commonly used training load metrics in cycling: training stress score, Edwards' training impulse, and session rating of perceived exertion. We provide step-by-step guidance on evaluating and predicting these metrics using practical, well-illustrated examples drawn from the data of a competitive cyclist. The methodology review includes the visualization and interpretation of relationships between metrics via scatterplots and regression analyses, both with and without intercepts, and in linear and curvilinear forms. We also introduce the use of partial correlation to examine associations between metrics while controlling for exercise duration thereby addressing a frequent confounding factor. A worked example illustrates how data can be used to derive session-specific carbohydrate and energy targets. By following the procedures outlined here, undergraduate and postgraduate students as well as early-career practitioners can enhance their understanding of training load monitoring and develop tailored strategies suited to individual cyclists and contextual constraints including training and nutrition periodization decisions. The included spreadsheet instructions and supplementary R script support replication and facilitate the integration of these methods into applied practice.Arthur Henrique Bossi; Guilherme Matta; Pedro Lima; Maurício Bara-Filho

Session (web analytics); Metric (unit); Rating of perceived exertion; Visualization; Training (meteorology); Duration (music); Linear regression; Periodization; Confounding; Computer science; Machine learning; Data mining; Range (aeronautics); Replication (statistics); Regression analysis; Perceived exertion; Energy (signal processing); Estimation

2026-01-01https://doi.org/10.1123/ijsnem.2026-0028International Journal of Sport Nutrition and Exercise Metabolism 20261Die Geometrie der Raum-Zeit und die Definition des MetersB. Lesche

Subject (documents); Calculus (dental); Die (integrated circuit); Philosophy

2026-01-01https://doi.org/10.1007/978-3-662-73561-9_7 20261Invarianz der Lichtgeschwindigkeit und relative GleichzeitigkeitB. Lesche

Power (physics); Order (exchange); Duration (music)

2026-01-01https://doi.org/10.1007/978-3-662-73561-9_4 20261Mitochondrial remodeling in obesity: mechanistic links to impaired energy metabolism and therapeutic perspectivesObesity is characterized not only by excessive adiposity but also by profound disturbances in cellular and systemic energy homeostasis. Metabolic inflexibility, defined as the impaired ability to adapt substrate utilization in response to nutrient availability and energetic demands, has emerged as a central feature of obesity-associated metabolic dysfunction. Increasing evidence suggests that mitochondrial remodeling represents an important mechanism linking obesity to tissue-specific metabolic alterations, systemic metabolic dysfunction, and insulin resistance. Across adipose tissue, skeletal muscle, and liver, obesity induces tissue-specific alterations in mitochondrial biogenesis, dynamics, oxidative metabolism, quality-control pathways, and redox signaling, ultimately disrupting substrate utilization and insulin signaling. Importantly, mitochondrial adaptations appear highly dynamic and context dependent, suggesting that certain responses may initially arise as compensatory mechanisms before becoming maladaptive during disease progression. In addition, translational differences between experimental models and humans contribute to the heterogeneity observed in obesity-associated mitochondrial phenotypes. Here, we integrate preclinical and clinical evidence to examine the molecular mechanisms underlying tissue-specific mitochondrial remodeling and its contribution to metabolic inflexibility. We further discuss how lifestyle, pharmacological, and surgical interventions modulate mitochondrial pathways involved in restoring metabolic flexibility and improving metabolic health. Collectively, this review highlights tissue-specific mitochondrial remodeling as a dynamic and context-dependent process linking obesity to metabolic inflexibility and impaired metabolic adaptability, while identifying mitochondrial plasticity as a promising therapeutic target.Welington Henrique Justo Neto; Camila de Oliveira Ramos; Cláudio Teodoro de Souza

Energy metabolism; Mitochondrion; Metabolism; Bioenergetics; Mechanism (biology); Energy expenditure; Chemistry; Cell biology; Neuroscience; Biology

2026-06-18https://doi.org/10.1016/j.physbeh.2026.115427Physiology & Behavior 20261Competência cultural em saúdeObjetivou-se analisar a associação entre competência cultural e características sociodemográficas entre profissionais de saúde no Brasil. Trata-se de um estudo exploratório e correlacional, em amostra de conveniência não-probabilística de quatro regiões do país. Foram selecionados 213 participantes, predominantemente mulheres (73,7%), com média de idade de 37,9 anos (DP=10,4) e média de tempo de atuação de 11.2 anos (DP=9,2), de seis Unidades da Federação (Ceará, Distrito Federal, Minas Gerais, Piauí, Rio Grande do Norte e Rio Grande do Sul) e com os/as quais foram aplicados dois instrumentos: questionário sociodemográfico e escala EMCC14-BR. Para se estabelecer a associação de variáveis, foram realizadas análises bivariadas (Qui-Quadrado, Teste t, ANOVA) e posteriormente Análise de Regressão Logística. No modelo de associação final, encontrou-se que a formação universitária (OR=2,15; IC=1,16–2,15) e na área de Humanas e Sociais (OR=3,08; IC=1,41-6,72) estão relacionadas a maior competência cultural. Assim, os achados indicam a importância da formação voltada para os/as profissionais como parte das estratégias de educação permanente em saúde, possibilitando práticas de cuidado culturalmente sensíveis. Tendo em vista as limitações da amostragem por conveniência, recomenda-se que futuras pesquisas explorem, com amostras probabilísticas e recortes regionais mais equilibrados, os determinantes contextuais da competência cultural, ampliando a compreensão das desigualdades no cuidado em saúde no Brasil.Magda Dimenstein; Telmo Mota Ronzani; João Paulo Macedo; Jáder Ferreira Leite; Simone Mainieri Paulon; Maria Inês Gandolfo Conceição; Mariana Tavares Cavalcanti Liberato

Sample (material); Test (biology); Immigration; Scale (ratio); Ethnic group; Power (physics); Gerontology; History; Medicine; Demography; Humanities; Socioeconomics

2026-06-18https://doi.org/10.57167/rev-sbph.2026.v29.919Revista da SBPH 20261Spacetime Densification Theory: the nonlinear AQUAL bridge and the galactic transition scaleWe formulate the quasi-static galactic-sector bridge between the Newtonian limit of Spacetime Densification Theory and its SPARC/RAR phenomenology: an AQUAL-type k-essence completion of the densification kinetic sector. We derive, in closed form, the kinetic function F(ξ) = √(ξ(1+ξ)) − sinh−1√ξ, whose quasi-static field equation is the elliptic Bekenstein–Milgrom equation with the standard interpolating function, recovering the Newtonian limit at high gradient and the deep-MOND limit at low gradient. The associated propagating mode is ghost-free; its longitudinal characteristic speed on the static galactic background, v∥2/c2 = (2+ξ)/(1+ξ) ∈ [1, 2], is superluminal in the deep-MOND regime — generic to AQUAL-type theories — yet the theory remains causal because the substrate selects a preferred frame furnishing a global time function. These results fix the form of the radial acceleration relation and the slope-4 baryonic Tully–Fisher relation vc4 = GMba†, and are independent of the absolute scale. We then show that the transition scale reduces to a single dimensionless closure constant τ, through a†(τ) = (√τ/2π) cH0√(2ΩΛ), with the phase-space factor 6π2, the kinetic stiffness, and the inheritance of the cohesive energy density all derived. We do not derive τ: six independent microscopic routes are tested, and none, within the present coarse-grained substrate framework, yields the value τ = 1 required to place a† at the observed MOND scale (within 1.6% of a0, and bracketed by the SPARC estimators τ ∈ [0.89, 1.08]). We adopt τ = 1 as a calibrated statistical closure, and advance its universality across galaxies — required by the tightness of the radial acceleration relation — as a falsifiable prediction tested by the intrinsic scatter. The closure constant τ is found to share the infrared-versus-ultraviolet fine-tuning structure of the cosmological-constant problem: the substrate carries two vacuum-level calibration constants — the cohesive coupling χ, fixed to ΩΛ, and τ, fixed to a0 — that protect the effective description from ultraviolet overshoots. In summary, within the quasi-static galactic sector the densification programme fixes the form of the galactic dynamics and anchors the scale to a single universal calibrated constant whose universality is falsifiable; the result is the galactic AQUAL bridge of SDT, not a complete cosmological replacement for dark matter. It does not derive a0 from first principles, but reduces it to one named constant and identifies the linkage of χ and τ — which, if realized by a common ultraviolet completion, would predict a0 = cH0√(2ΩΛ)/2π — as the controlling open problem.Paulo Giovanni de Albuquerque Suassuna

Newtonian dynamics; Dimensionless quantity; Spacetime; Nonlinear system; Newtonian limit; Kinetic energy; Limit (mathematics); Newtonian fluid; Superluminal motion; Geodesic; Physics; Classical mechanics; Effective field theory; Rest frame; Conservation law; Galaxy; Acceleration

2026-06-18https://doi.org/10.5281/zenodo.20748634Zenodo (CERN European Organization for Nuclear Research) 20261Lösungen der ÜbungenB. Lesche

2026-01-01https://doi.org/10.1007/978-3-662-73561-9_14

20261Koordinaten in der Raum-ZeitB. Lesche

Order (exchange); Work (physics); Period (music); Computer science; Physics

2026-01-01https://doi.org/10.1007/978-3-662-73561-9_5 20261Spatial and temporal prediction of Aedes aegypti populations with atmospheric and urban forms dependenceAccurately predicting mosquito population dynamics in cities requires models that couple climatic sensitivity with urban spatial heterogeneity. We developed a spatially explicit, climate-driven framework that integrates satellite imagery, field observations, and biology to simulate Aedes aegypti dynamics across heterogeneous urban landscapes. A decomposition technique was introduced to disentangle entomological observations from mixed urban sites into landscape-specific time series for houses, streets, and parks. We provide a robust parameter estimation through a constrained inverse problem, revealing distinct temperature responses and biological processes across environments. Model validation against both egg and adult mosquito data from five Brazilian cities yielded strong correlations with the majority falling between ρ = 0.4 and 0.8, confirming the model’s ability to reproduce observed spatiotemporal patterns. This integration of climate dependence, landscape quantification, and empirical validation provides a potential tool for anticipating mosquito abundance across space and time. By identifying periods and locations of elevated risk, the framework supports targeted, cost-effective interventions against dengue and other vector-borne diseases in a rapidly urbanizing and warming world.Pedro H. G. Lugão; Monalisa Reis Da Silva; Raphael Cascelli; Grigori Chapiro

Population; Temporal scales; Abundance (ecology); Climate change; Spatial ecology; Field (mathematics); Estimation; Satellite; Environmental science; Geography; Ecology; Climatology; Meteorology

2026-06-18https://doi.org/10.1073/pnas.2533964123Proceedings of the National Academy of Sciences 20261EinleitungB. Lesche

Subject (documents); Absoluteness; Term (time); Ontological argument; Philosophy; Epistemology; Humanities

2026-01-01https://doi.org/10.1007/978-3-662-73561-9_1 20261Effect of buserelin acetate at artificial insemination on pregnancy per AI in dairy cows inseminated with sexed semenThis study determined whether administration of buserelin acetate (BA), a gonadotropin-releasing hormone agonist, during timed artificial insemination (TAI) improves pregnancy per AI (P/AI) of dairy cows inseminated with sexed semen. A total of 116 Girolando cows from three commercial dairy farms were randomly assigned to two treatment groups: Buserelin Group (BG; n = 58) that received 10 μg BA during AI, and Control Group (CG; n = 58) that did not receive an ovulation inducer. All animals were subjected to a standard ovulation-synchronization protocol, with AI performed 48 h after removing the progesterone device. Cyclicity status at the beginning of the protocol and preovulatory follicle (POF) diameter were included as covariates in statistical analysis. No significant difference in P/AI was observed between treatments (22.4% in BG vs. 13.8% in CG; P = 0.11). Exploratory subgroup analyses indicated a numerical tendency toward relatively high P/AI in anestrous cows treated with BA at the beginning of the protocol. Additionally, cows in BG with a POF < 13 mm showed numerically greater P/AI than did those with POF ≥ 13 mm. Overall, BA administration during AI did not significantly improve P/AI in dairy cows impregnated with sexed semen. The subgroup findings should be cautiously interpreted as the study was not specifically designed or powered for these comparisons. Further studies with relatively large populations are warranted to confirm these potential associations.M. Da Costa; Rodrigo Vasconcelos de Oliveira; Samuel Rodrigues Bonamichi do Couto; Nicolas Moreira Piedras Monnerat Caparelli; Thiago Souza Vieira; Raphael Azevedo Lamim; Daniela Cristina Rocha de Freitas; Marco Roberto Bourg de Mello

Artificial insemination; Buserelin; Pregnancy; Ovulation; Insemination; Semen; Pregnancy rate; Animal science; Gynecology; Dairy cattle; Medicine; Andrology; Biology; Infertility; Ovulation induction; Fertility

2026-01-01https://doi.org/10.29374/2527-2179.bjvm003726Brazilian Journal of Veterinary Medicine/Revista Brasileira de Medicina Veterinária 20261Mechanistic advances in multicomponent reactions: a focus on solvent and component effectsMulticomponent reactions (MCRs) are powerful tools in organic synthesis, enabling the rapid assembly of structurally complex molecules from simple building blocks. Despite their synthetic efficiency and broad applicability, the mechanistic pathways underlying these transformations often remain insufficiently understood due to the complex interplay between solvents, reagents, additives, catalysts, and multiple reactive intermediates, which can enable competing reaction pathways. In recent years, advances in computational chemistry and high-resolution mass spectrometry have provided valuable insights into these processes, revealing non -classical features such as the catalytic role of reagents, solvent participation as pseudo -reactants, and the viability of intermediates previously considered unstable. This manuscript highlights representative studies on classical MCRs, including the Biginelli, Passerini, Ugi, and Groebke–Blackburn–Bienaymé reactions, as well as ketene-based variants, emphasizing how mechanistic investigations have reshaped current understanding of these transformations. Particular attention is given to the role of solvents and individual reaction components in modulating reaction pathways and influencing mechanistic outcomes. These studies contribute to a more detailed understanding of multicomponent processes, providing a basis for the rational development and modification of these transformations.Marcelo H.R. Carvalho; Pedro P. de Castro; Giovanni W. Amarante

Component (thermodynamics); Reactive intermediate; Solvent; Focus (optics); Process (computing); Mechanism (biology); Catalysis; Solvent effects; Chemistry; Biochemical engineering; Computational chemistry; Nanotechnology; Combinatorial chemistry; Reaction mechanism; Rational design

2026-06-18https://doi.org/10.1016/j.tetlet.2026.156169Tetrahedron Letters 20261Spacetime Densification Theory: the nonlinear AQUAL bridge and the galactic transition scaleWe formulate the quasi-static galactic-sector bridge between the Newtonian limit of Spacetime Densification Theory and its SPARC/RAR phenomenology: an AQUAL-type k-essence completion of the densification kinetic sector. We derive, in closed form, the kinetic function F(ξ) = √(ξ(1+ξ)) − sinh−1√ξ, whose quasi-static field equation is the elliptic Bekenstein–Milgrom equation with the standard interpolating function, recovering the Newtonian limit at high gradient and the deep-MOND limit at low gradient. The associated propagating mode is ghost-free; its longitudinal characteristic speed on the static galactic background, v∥2/c2 = (2+ξ)/(1+ξ) ∈ [1, 2], is superluminal in the deep-MOND regime — generic to AQUAL-type theories — yet the theory remains causal because the substrate selects a preferred frame furnishing a global time function. These results fix the form of the radial acceleration relation and the slope-4 baryonic Tully–Fisher relation vc4 = GMba†, and are independent of the absolute scale. We then show that the transition scale reduces to a single dimensionless closure constant τ, through a†(τ) = (√τ/2π) cH0√(2ΩΛ), with the phase-space factor 6π2, the kinetic stiffness, and the inheritance of the cohesive energy density all derived. We do not derive τ: six independent microscopic routes are tested, and none, within the present coarse-grained substrate framework, yields the value τ = 1 required to place a† at the observed MOND scale (within 1.6% of a0, and bracketed by the SPARC estimators τ ∈ [0.89, 1.08]). We adopt τ = 1 as a calibrated statistical closure, and advance its universality across galaxies — required by the tightness of the radial acceleration relation — as a falsifiable prediction tested by the intrinsic scatter. The closure constant τ is found to share the infrared-versus-ultraviolet fine-tuning structure of the cosmological-constant problem: the substrate carries two vacuum-level calibration constants — the cohesive coupling χ, fixed to ΩΛ, and τ, fixed to a0 — that protect the effective description from ultraviolet overshoots. In summary, within the quasi-static galactic sector the densification programme fixes the form of the galactic dynamics and anchors the scale to a single universal calibrated constant whose universality is falsifiable; the result is the galactic AQUAL bridge of SDT, not a complete cosmological replacement for dark matter. It does not derive a0 from first principles, but reduces it to one named constant and identifies the linkage of χ and τ — which, if realized by a common ultraviolet completion, would predict a0 = cH0√(2ΩΛ)/2π — as the controlling open problem.Paulo Giovanni de Albuquerque Suassuna

2026-06-18https://doi.org/10.5281/zenodo.20748635Zenodo (CERN European Organization for Nuclear Research) 20261Der Doppler-Effekt und die relativistische LichtaberrationB. Lesche

Fusible alloy; Work (physics); Field (mathematics)

2026-01-01https://doi.org/10.1007/978-3-662-73561-9_8 20261When the Inspector Knocks at the Door: Effects of Labor Inspections in BrazilGustavo Gonzaga; Isis Lira; Ricardo da Silva Freguglia; Tomás Guanziroli; Laura Schiavon

Sanctions; Wage; Affect (linguistics); Scope (computer science); Efficiency wage; Deterrence theory; Labor contract; Labour economics; Business; Economics; Temporary work; Aggregate data; Labor mobility; Incentive

2026-01-01https://doi.org/10.2139/ssrn.6954093SSRN Electronic Journal 20261Das zweite Newtonsche GesetzB. Lesche

Order (exchange); Field (mathematics); Context (archaeology); Term (time); Political science

2026-01-01https://doi.org/10.1007/978-3-662-73561-9_11 20261Absolute ZeitmessungenB. Lesche

Object (grammar); Einstein; Subject (documents); Philosophy; Humanities; Physics

2026-01-01https://doi.org/10.1007/978-3-662-73561-9_3 20261Der 4-ImpulsB. Lesche

Context (archaeology); Limiting; Component (thermodynamics); Identification (biology); Computer science

2026-01-01https://doi.org/10.1007/978-3-662-73561-9_10 20261Uma meta-arqueogenealogia da noção foucaultiana de monumentoA partir da identificação de uma lacuna em textos exegéticos que visam apresentar o conjunto teórico foucaultiano, qual seja, a ora inexistente ora brevíssima menção à noção de monumento tal como rascunhada pelo filósofo, desenvolvemos uma pesquisa bibliográfica com vistas a lhe dar maior inteligibilidade. Para tanto, em termos metodológicos, instrumentalizamo-nos de ferramentas conceituais elaboradas pelo próprio Foucault para catalogar, selecionar e analisar uma série de enunciados considerados pertinentes ao nosso problema, sejam produzidos por Foucault, sejam produzidos por alguns de seus contemporâneos, propondo, por assim dizer, uma meta-arqueogenealogia da noção de monumento. Como resultado desta investigação, apresentaremos as condições de emergência e de funcionamento da noção no seio da arqueogenealogia a que chegamos e que nos levaram à tese de que a ideia de monumento está na base da mudança metodológica de Foucault de uma perspectiva arqueológica para uma análise genealógica de enunciados. A partir de um exemplo recente na análise do discurso, sugerimos que a atenção à condição monumental do discurso pode ser um aspecto caro ao linguista, sobretudo nos termos da historicidade e das posições ideológicas que nossas práticas linguísticas materializam.Ana Carolina Neves Dias; Ana Paula Grillo El-Jaick

Order (exchange); Object (grammar); Plot (graphics); Context (archaeology); Philosophy

2026-05-26https://doi.org/10.14393/htp-v8n1-2026-79565Revista Heterotópica 20261Rückblick auf Raum und Zeit in der nichtrelativistischen PhysikB. Lesche

Limiting; Order (exchange); Context (archaeology); Philosophy; Physics

2026-01-01https://doi.org/10.1007/978-3-662-73561-9_2 20261Die EigenzeitB. Lesche

Interpretation (philosophy); Field (mathematics); DASS; Process (computing)

2026-01-01https://doi.org/10.1007/978-3-662-73561-9_9 20261KosmologieB. Lesche

Event (particle physics); State (computer science); Power (physics); Work (physics); Humanities

2026-01-01https://doi.org/10.1007/978-3-662-73561-9_13 20261CIRURGIA GUIADA SEM RETALHO NA MANDÍBULA POSTERIOR ATRÓFICA: LIMITES DE SEGURANÇA PARA INSTALAÇÃO DE IMPLANTES PRÓXIMOS AO CANAL MANDIBULARA cirurgia guiada sem retalho tem sido amplamente utilizada na implantodontia contemporânea por proporcionar maior previsibilidade cirúrgica e menor morbidade pós-operatória. Entretanto, em pacientes com mandíbula posterior atrófica, a proximidade entre a crista óssea residual e o canal mandibular representa um importante desafio para a instalação segura de implantes dentários. O presente estudo teve como objetivo analisar as evidências científicas publicadas nos últimos dez anos acerca dos limites de segurança para instalação de implantes próximos ao canal mandibular em cirurgias guiadas sem retalho realizadas na mandíbula posterior atrófica. Trata-se de uma revisão integrativa da literatura, realizada nas bases de dados PubMed/MEDLINE, Scopus, Web of Science e Cochrane Library. Após aplicação dos critérios de elegibilidade, foram selecionados sete estudos para compor a amostra final. Os resultados demonstraram que a cirurgia guiada associada ao planejamento tridimensional contribui significativamente para o aumento da precisão cirúrgica e para a redução do risco de complicações anatômicas. Contudo, desvios lineares e angulares entre o planejamento virtual e a posição final dos implantes ainda podem ocorrer, justificando a manutenção de margens de segurança em relação ao canal mandibular. As evidências analisadas indicam que a distância aproximada de 2 mm entre o ápice do implante e o canal mandibular permanece como a conduta mais prudente e respaldada pela literatura científica atual. Conclui-se que a cirurgia guiada sem retalho constitui uma alternativa segura e previsível para a reabilitação da mandíbula posterior atrófica, desde que associada a planejamento criterioso e respeito aos limites anatômicos estabelecidos.Célio Augusto Pimentel Arcanjo; Roberto Machado Cruz; Ana Beatriz Bezerra Barros; Brunno Pereira Silva; Cristiano Veloso; Rebeca Vidal Capelupi; Ana Beatriz Nunes Santos e Silva Barroso; Caroline dos Santos Alcantara Oliveira; José da Silva Júnior; Idalisio Soares Aranha Neto; Marco Aurélio Blaz Vasques; Cristina Carla Xavier da Silva; Elton Elemer Finger; Gabriell Mafuz Penteado

Mandibular canal; Root canal; Posterior teeth; Endodontics; Medicine; Dentistry; Gynecology; Orthodontics

2026-06-18https://doi.org/10.51891/rease.v12i6.27957Revista Ibero-Americana de Humanidades, Ciências e Educação 20261Relendo a história do Brasil a contrapeloMicheliny Verunschk, escritora brasileira em atividade desde 2003, recebeu renovada atenção em 2022 ao ganhar o Prêmio Jabuti de Romance Literário e ficar em 3° lugar no Prêmio Oceanos, ambos pelo romance O som do rugido da onça (2021). Na presente pesquisa, foi efetuada uma revisão da literatura sobre a obra, a fim de elucidar padrões e apontar novos caminhos de estudo, partindo da hipótese da importância do procedimento de “escovar a história a contrapelo”, descrito por Walter Benjamin (1987). Foram identificadas 27 publicações inéditas cujo objeto principal (isolado ou em comparação) foi o romance, do período entre 2021 e o início de 2026. Finalmente, foi investigada a presença, ou ausência, de estudos sobre produções literárias posteriores da autora.João Felipe Rodrigues

Process (computing); Object (grammar); Work (physics); Order (exchange); Reading (process); Computer science

2026-06-15https://doi.org/10.22456/2236-6385.153732Cadernos do IL 20261Efficacy of botulinum toxin for masseter muscle hypertrophy: A systematic review and meta-analysisG.F. Machado; L.R. De Freitas; L.F.S Ribeiro; G.R.O Andrade; V.P. Silva; Thiago Silva; V.H.S. Lima; P.V. Rezende; T.A. Almeida; F Carvalho Torres; L K Rodrigues

Masseter muscle; Botulinum toxin; Skeletal muscle; Electromyography; Muscle contraction; Muscle relaxation; Muscle relaxant; Medicine; Anesthesia

2026-06-18https://doi.org/10.1016/j.bjps.2026.06.012Journal of Plastic Reconstructive & Aesthetic Surgery 20261Allgemeine RelativitätstheorieB. Lesche

Gravitation; Formalism (music); Context (archaeology); Theory of relativity; Philosophy; Physics; Humanities

2026-01-01https://doi.org/10.1007/978-3-662-73561-9_12 20261One-loop radiative routing in Spacetime Densification Theory: stability of the physical composite metricSpacetime Densification Theory (SDT) is an emergent-gravity framework in which matter and the leading tensorial sector couple universally to a composite physical metric built from a coarse-grained substrate density . We ask whether the relativistic infrared architecture of this framework is radiatively stable by integrating out a representative scalar matter field at one loop, as a proof of concept, with the proper-time integral regulated at the physical substrate cutoff , and determining the operator routing implied by universal coupling to the physical metric. Extension to the complete Standard-Model spectrum, which alone fixes the sign and magnitude of the induced couplings, remains open. Under universal coupling to and an invertible, purely density-dependent disformal map, the one-loop matter divergences are not destructive but routed into specific sectors. Assuming a vacuum-shift-invariant completion built on the physical measure — a hypothesis whose explicit construction is left to future work — the quartically divergent vacuum energy, and with it the entire disformal tower carried by the same measure, is removed by the vacuum-shift-invariant subtraction assumed in A3, protecting the induced densification potential and the screening mass of the densification mode against the cutoff scale. No independent power-law counterterm for the unnormalized conformal slope arises from the quartic and quadratic sectors in the chosen parametrization; the physical canonically normalized response is not radiatively invariant, since it depends on and , both of which flow. The quadratic curvature contribution induces the tensorial coefficient along the Sakharov route — supplying a candidate dynamical origin for the Einstein–Hilbert term introduced by infrared matching in the relativistic completion — and renormalizes the induced-channel part of the kinetic stiffness in a locked relation, , parameter-free within the covariantly induced Einstein–Hilbert channel. The Newtonian calibration is thereby reinterpreted as a renormalization condition, not a radiatively invariant identity. The disformal sector is Horndeski — the most protected locus of DHOST Class-Ia — because a purely density-dependent disformal transformation of the Einstein–Hilbert seed preserves the Horndeski structure (Bettoni–Liberati; Zumalacárregui–García-Bellido); the one-loop flow preserves it in the leading channel, with the propagating-mode count unchanged. The logarithmic sector generates the usual curvature-squared EFT counterterms, whose apparent additional pole lies near the breakdown scale and cannot be interpreted within the leading infrared truncation. We do not derive Newton’s constant, the framework functions, the vacuum-sequestering completion, or an ultraviolet completion; we identify a controlled one-loop routing, with logical status stated result by result and the open closures listed explicitly. The central conclusion within the stated assumptions — particularly on the Sakharov-dominated branch — is a relocation of the framework’s central difficulty: the radiative bottleneck of SDT is the renormalized kinetic stiffness , whose loop dressing links, through one locked relation, the microscopic substrate, the Sakharov tensorial sector, and the galactic transition scale of the AQUAL bridge.Paulo Giovanni de Albuquerque Suassuna

Spacetime; Scalar (mathematics); Cutoff; Metric (unit); Stability (learning theory); Curvature; Conformal map; Quadratic equation; Scalar field; Physics; Theoretical physics; Measure (data warehouse); Coupling (piping); Operator (biology); Symmetry (geometry); Field (mathematics); Work (physics); Matching (statistics)

2026-06-19https://doi.org/10.5281/zenodo.20762077Zenodo (CERN European Organization for Nuclear Research) 20261TRANSITIONAL CARE IN THE HOSPITAL DISCHARGE OF PEOPLE WITH CANCER TO PROMOTE PALLIATIVE CAREObjective To analyze the potential of organizational transition care as a strategy for promoting palliative care following hospital discharge of elderly people with cancer from the perspective of the oncology nurse’s work. Methods This was a descriptive, exploratory, qualitative study that employed a case study approach based on Robert Yin’s methodology and Meleis’s Theory of Transitions. The study was conducted from May 2023 to April 2024 at a hospital specializing in oncology care, located in the Zona da Mata Mineira region. The participants were nine clinical nurses. Data were collected through interviews, recorded using a smartphone. Data transcription was performed manually and stored in a notepad. For data analysis, the software Interface de R pour les Analyses Multidimensionnelles de Textes et de Questionnaires (Iramuteq) was used; the analysis began with data collection and organization, deepening with the re-reading of the material and the construction of the textual corpus analyzed by Iramuteq. Subsequently, the dendrogram was analyzed to understand the context of the lexical analysis. Results The analyzed material resulted in three categories and six classes; in this article, the results of class four were discussed. Conclusion The potential of organizational transition care was highlighted based on the practice of oncology nurses, revealing the leading role of these professionals on the front lines of this care.Nicacia Cristina Cunha Costa; Tayene de Oliveira Souza; Edna Aparecida Barbosa de Castro; Nádia Fontoura Sanhudo

Palliative care; Context (archaeology); Qualitative research; Data collection; Hospital discharge; Perspective (graphical); Cancer; Participant observation; Medicine; Nursing; Transitional care; Family medicine; End-of-life care; Content analysis; Descriptive statistics; Oncology

2026-05-28https://doi.org/10.21675/2357-707x.2026.v17.e-2026026iEnfermagem em Foco 20261Nephrologists’ Barriers to Kidney Transplant ReferralH. Sanders-Pinheiro; P.C. Souza; I.C. Paulino; F.F. Fernandes; A.R. Almeida; L.S. Ulisses; T. Sandes-Freitas; L. Modelli de Andrade; J.A. Moura-Neto

Referral; Kidney transplantation; Kidney transplant; Dialysis; Patient referral; Transplantation; Kidney; Medicine; Intensive care medicine; Listing (finance); Kidney disease; Internal medicine; MEDLINE; Incidence (geometry)

2026-06-01https://doi.org/10.1016/j.ajt.2026.05.1739American Journal of Transplantation 20261LA ATENCIÓN DE TRANSICIÓN EN EL ALTA HOSPITALARIA DE PERSONAS CON CÁNCER PARA LA PROMOCIÓN DE LOS CUIDADOS PALIATIVOSObjetivo Analizar el potencial de la atención de transición organizativa como estrategia para promover los cuidados paliativos tras el alta hospitalaria de personas mayores con cáncer desde la perspectiva del trabajo del enfermero oncológico. Métodos Estudio descriptivo, exploratorio y cualitativo, que adopta el método del estudio de caso según Robert Yin y la Teoría de las Transiciones de Meleis. Se llevó a cabo entre mayo de 2023 y abril de 2024 en un hospital especializado en atención oncológica, situado en la Zona da Mata Mineira. Los participantes fueron nueve enfermeros de atención directa. Los datos se recopilaron mediante entrevistas, grabadas con la ayuda de un smartphone. La transcripción de los datos se realizó manualmente y se archivó en un bloc de notas. Para el análisis de los datos se utilizó el software Interface de R pour les Analyses Multidimensionnelles de Textes et Questionnaires (Iramuteq); el análisis se inició desde la recopilación y organización de los datos, profundizándose con la relectura del material y la construcción del corpus textual analizado por Iramuteq. Posteriormente, se analizó el dendrograma para comprender el contexto del análisis léxico. Resultados El material analizado dio lugar a tres categorías y seis clases; en este artículo se discuten los resultados de la clase cuatro. Conclusión Se pusieron de manifiesto las potencialidades de la atención de transición organizacional a partir de la práctica de los enfermeros en oncología, revelando el protagonismo de este profesional en la primera línea de dicha atención.Nicacia Cristina Cunha Costa; Tayene de Oliveira Souza; Edna Aparecida Barbosa de Castro; Nádia Fontoura Sanhudo

Context (archaeology); Palliative care; Persona; Nursing care; Humanities; Political science; Philosophy

2026-05-28https://doi.org/10.21675/2357-707x.2026.v17.e-2026026eEnfermagem em Foco 20261Chronic Stress Predictability Modulates the Severity of Apical Periodontitis Induced in Wistar RatsAIM: To evaluate the effects of predictable and unpredictable chronic stress on the development and severity of periapical lesions in rats. METHODOLOGY: Thirty-two male Wistar rats were randomly allocated into four groups (n = 8 each): control, apical periodontitis without stress, apical periodontitis with predictable stress, and apical periodontitis with unpredictable stress. Emotional stress protocols were applied for 42 days, and apical periodontitis was induced on day 21 by pulp exposure. Stress induction was confirmed through behavioural evaluation using the open field and Y-maze tests. The severity of periapical lesions was assessed by microcomputed tomography and histological analysis. Data were analysed using Student's t-test, Mann-Whitney, one-way ANOVA, or Kruskal-Wallis tests (p < 0.05). RESULTS: Behavioural tests confirmed successful stress induction, with both stressed groups demonstrating reduced exploratory activity compared to non-stressed animals. Animals exposed to unpredictable stress developed significantly larger periapical lesions and exhibited higher inflammatory infiltrate scores than those subjected to predictable stress or no stress (p < 0.05). Microcomputed tomography findings corroborated the histological results, confirming the greater severity of apical periodontitis in the unpredictable stress group (p < 0.05). CONCLUSION: Unpredictable chronic stress significantly exacerbated the development and severity of periapical lesions, suggesting that stress predictability may act as a modulatory factor in apical periodontitis progression.Giovanna Bignoto Minhoto; Gustavo G. Guerrero; Rayana D. Khoury; Carolina O. Lima; Carolina F. Gagliardi; Camila G. C. Barbosa; Emmanuel João Nogueira Leal Silva; Márcia Carneiro Valera

Periodontitis; Chronic periodontitis; Chronic stress; Periodontium; Pulp (tooth); Medicine; Dentistry; Internal medicine; Periapical periodontitis; Pathology; Stress (linguistics)

2026-06-19https://doi.org/10.1111/iej.70203International Endodontic Journal 20261One-loop radiative routing in Spacetime Densification Theory: stability of the physical composite metricSpacetime Densification Theory (SDT) is an emergent-gravity framework in which matter and the leading tensorial sector couple universally to a composite physical metric built from a coarse-grained substrate density . We ask whether the relativistic infrared architecture of this framework is radiatively stable by integrating out a representative scalar matter field at one loop, as a proof of concept, with the proper-time integral regulated at the physical substrate cutoff , and determining the operator routing implied by universal coupling to the physical metric. Extension to the complete Standard-Model spectrum, which alone fixes the sign and magnitude of the induced couplings, remains open. Under universal coupling to and an invertible, purely density-dependent disformal map, the one-loop matter divergences are not destructive but routed into specific sectors. Assuming a vacuum-shift-invariant completion built on the physical measure — a hypothesis whose explicit construction is left to future work — the quartically divergent vacuum energy, and with it the entire disformal tower carried by the same measure, is removed by the vacuum-shift-invariant subtraction assumed in A3, protecting the induced densification potential and the screening mass of the densification mode against the cutoff scale. No independent power-law counterterm for the unnormalized conformal slope arises from the quartic and quadratic sectors in the chosen parametrization; the physical canonically normalized response is not radiatively invariant, since it depends on and , both of which flow. The quadratic curvature contribution induces the tensorial coefficient along the Sakharov route — supplying a candidate dynamical origin for the Einstein–Hilbert term introduced by infrared matching in the relativistic completion — and renormalizes the induced-channel part of the kinetic stiffness in a locked relation, , parameter-free within the covariantly induced Einstein–Hilbert channel. The Newtonian calibration is thereby reinterpreted as a renormalization condition, not a radiatively invariant identity. The disformal sector is Horndeski — the most protected locus of DHOST Class-Ia — because a purely density-dependent disformal transformation of the Einstein–Hilbert seed preserves the Horndeski structure (Bettoni–Liberati; Zumalacárregui–García-Bellido); the one-loop flow preserves it in the leading channel, with the propagating-mode count unchanged. The logarithmic sector generates the usual curvature-squared EFT counterterms, whose apparent additional pole lies near the breakdown scale and cannot be interpreted within the leading infrared truncation. We do not derive Newton’s constant, the framework functions, the vacuum-sequestering completion, or an ultraviolet completion; we identify a controlled one-loop routing, with logical status stated result by result and the open closures listed explicitly. The central conclusion within the stated assumptions — particularly on the Sakharov-dominated branch — is a relocation of the framework’s central difficulty: the radiative bottleneck of SDT is the renormalized kinetic stiffness , whose loop dressing links, through one locked relation, the microscopic substrate, the Sakharov tensorial sector, and the galactic transition scale of the AQUAL bridge.Paulo Giovanni de Albuquerque Suassuna

2026-06-19https://doi.org/10.5281/zenodo.20762078Zenodo (CERN European Organization for Nuclear Research) 20261Bridging the Gap: Geographic and Clinical Inequities in Kidney Transplantation in BrazilG. Ferreira; Y. Low; L. Modelli de Andrade; J. Bastos; D. Salomao; M.L. Levan; D. Segev; A.B. Massie

Transplantation; Kidney transplantation; Equity (law); Bridging (networking); MEDLINE; Healthcare system; Medicine; Intensive care medicine; Family medicine; Kidney transplant; Health care; Public health; United Network for Organ Sharing; Organ transplantation; Kidney disease

2026-06-01https://doi.org/10.1016/j.ajt.2026.05.1707American Journal of Transplantation 20261NEUROEDUCAÇÃO: COMO O CÉREBRO APRENDE E O PROFESSOR ENSINAo discutir as contribuições da neuroeducação para o processo de ensino e aprendizagem, este artigo teve como objetivo analisar as relações entre cérebro, aprendizagem e prática pedagógica, com ênfase na neuroplasticidade, na articulação entre emoção, memória e atenção, e nas estratégias pedagógicas capazes de favorecer envolvimento discente e aprendizagem significativa. O tema centrou-se na aproximação entre neurociência e educação, considerando como o conhecimento sobre o funcionamento cerebral pôde ampliar a compreensão do trabalho docente e das condições que favoreceram o aprender. Metodologicamente, realizou-se pesquisa bibliográfica, mediante seleção, leitura e análise de artigos científicos localizados em base acadêmica, com definição de descritores simples e critérios de inclusão e exclusão coerentes com o objeto investigado. Os resultados indicaram que a aprendizagem dependeu de experiências pedagógicas capazes de mobilizar atenção, curiosidade, participação e vínculos afetivos com o conteúdo, além de condições didáticas compatíveis com a plasticidade cerebral. Concluiu-se que a neuroeducação contribuiu para qualificar a reflexão sobre a docência, ao mostrar que ensinar não se restringiu à transmissão de informações, mas exigiu mediações intencionais que considerassem dimensões cognitivas, emocionais e sociais do estudante.Anick Danielle Bezerra Da Silva; Dionys Morais dos Santos; Simone Fernandes Fraga; Sivanildo de Sousa Martins; Juscelina Alves dos Santos

Perspective (graphical); Theme (computing); Subject (documents); Exploratory research; Class (philosophy); Philosophy; Psychology; Humanities

2026-06-21https://doi.org/10.46550/essw8y53Missioneira 20261As juventudes de direita redescobrem as ruasO presente trabalho analisa o papel das oportunidades políticas e discursivas nas mobilizações que marcaram os ciclos de protesto no Brasil contemporâneo. A partir da Teoria do Processo Político, investigamos os fatores que possibilitaram o reaparecimento e a consolidação de protestos alinhados a pautas das direitas nos ciclos de 1992, 2013 e 2015–2016. Argumentamos que a novidade não reside na emergência de um ativismo inédito, mas na reconfiguração da capacidade dessas juventudes de identificar, ocupar e explorar estruturas de oportunidade, articulando elementos organizativos, comunicacionais e simbólicos que lhes conferem maior visibilidade e condições de mobilização no período recente. Ao analisar os três ciclos, evidenciamos a transformação do papel público das juventudes de direita e sua inserção cada vez mais ativa na dinâmica política brasileira.Gustavo Paccelli; Christiane Jalles de Paula Paula

Work (physics); Legislation; Political science; Sociology

2026-06-15https://doi.org/10.14244/agenda.2025.2.1Revista Agenda Política 20261Endodontic filling material extrusion into the maxillary sinus: clinical presentation, microbiology, management, and outcomes—a systematic reviewThis systematic review aimed to consolidate the clinical presentation, diagnostic and microbial findings, management approaches, and outcomes of maxillary sinus involvement caused by extruded endodontic filling materials. Searches were performed in PubMed, Web of Science, Embase, Scopus, ScienceDirect, and ProQuest up to August 2025. Observational studies reporting extrusion of filling material into the maxillary sinus, accompanied by clinical, imaging, and/or surgical descriptions, were included. Study quality was critically analyzed using the Joanna Briggs Institute tools. Of 4076 articles initially retrieved, 52 were selected for full-text reading, 39 met the inclusion criteria and were included, comprising 34 case reports and 5 case series. Maxillary first molars were the most frequently involved teeth (59%). Extrusion occurred predominantly during primary endodontic treatment. Filling material was identified in the left maxillary sinus in 21 cases (47%) and in the right maxillary sinus in 24 cases (53%). Clinical presentations ranged from incidental asymptomatic findings to severe manifestations such as acute sinusitis. In the included studies, diagnosis was established using radiographic and tomographic imaging as well as direct endoscopic evaluation. Surgical removal represented the most common definitive management approach. Clinical outcomes were predominantly favorable, with complete symptom resolution and functional recovery. Extrusion of endodontic filling materials into maxillary sinus most often involves maxillary first molars and is associated with clinically significant complications, particularly fungal sinusitis. The present findings emphasize the need for prevention, accurate diagnosis, and timely interdisciplinary care of this iatrogenic event.Thamyres Magalhães Monteiro; Warley Oliveira Silva; Kaline Romeiro; Karim Aaazzouzi Raiss; Maryanne Terra Costa; Flávio R.F. Alves

Maxillary sinus; Oral and maxillofacial surgery; Asymptomatic; Sinusitis; Endodontics; Molar; Medicine; Dentistry; Orthodontics; Sinus (botany); Radiography; Maxilla

2026-06-22https://doi.org/10.1007/s10266-026-01469-2Odontology 20261New lanthanide complexes containing maltol and bipyridine ligands: Synthesis, solid state characterization, experimental and computational spectroscopic studies and their cytotoxic activitiesMaryene Alves Camargo; Daniel Silva Carvalho da Cunha; Augusto Alves Resende; Fernanda Sodré Rodrigues; Leonis Lourenço da Luz; Juliana A. B. Silva; Jéssica I.R. de Souza; Adailton J. Bortoluzzi; Alexandre Cuin; Kaíque A. D'Oliveira; Eduardo J. Nassar; Da Silva; Ricardo Bentes Azevedo

Maltol; Lanthanide; Solid-state; Bipyridine; 2,2'-Bipyridine; Cytotoxic T cell; Neodymium; Chemistry; Inorganic chemistry; Combinatorial chemistry; Stereochemistry; Crystallography

2026-06-22https://doi.org/10.1016/j.saa.2026.128299Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy 20261CONSIDERAÇÕES SOBRE O PAPEL FEMININO EM UMA SOCIEDADE EM TRANSFORMAÇÃOEsse artigo buscou apresentar, por meio de pequenos recortes históricos e relatos femininos, o percurso árduo que as mulheres trilharam para conquistar espaço e reconhecimento em uma sociedade em constante transformação. O estudo teve como objetivo discutir o fortalecimento do papel feminino nos diversos segmentos sociais, evidenciando desafios relacionados à desigualdade de gênero, ao preconceito e à desvalorização das escolhas das mulheres. A metodologia empregada fundamentou-se em pesquisa bibliográfica, dialogando com autores que abordam a temática, além da análise de narrativas de mulheres de diferentes contextos sociais, cujos relatos evidenciam experiências reais acerca dos múltiplos papéis desempenhados no cotidiano. Os discursos femininos presentes no trabalho demonstram força, resistência e capacidade de superação diante das exigências sociais e profissionais, rompendo com comportamentos historicamente pré-estabelecidos. Os resultados apontam que as mulheres já não admitem que seu poder de decisão seja menosprezado nos distintos espaços que ocupam na sociedade. Conclui-se que, apesar das importantes conquistas alcançadas ao longo dos anos, ainda há desafios a serem enfrentados para garantir igualdade, respeito e valorização do gênero feminino, sinalizando que a luta das mulheres deve continuar.Silvana Aparecida Caldas de Avila; Bárbara Cristina Ávila; Wallace Alves Cabral

Work (physics); Perspective (graphical); Politics; Theme (computing); Context (archaeology); Subject (documents); Sociology; Humanities; Political science

2026-06-22https://doi.org/10.51891/rease.v12i6.27658Revista Ibero-Americana de Humanidades, Ciências e Educação 20261O COLETIVO DE TRABALHO E O TRABALHO COLETIVO NO PNAIC: UM OLHAR A PARTIR DA CLÍNICA DA ATIVIDADERESUMO As reflexões apresentadas neste artigo tratam de alargar a compreensão do trabalho coletivo e o coletivo de trabalho a partir de um exemplo de política educacional – Pacto Nacional pela Alfabetização na Idade Certa (PNAIC) – com foco na alfabetização matemática, num diálogo aberto entre as áreas da educação e da Clínica da Atividade (psicologia), diante do desafio de garantir direitos de aprendizagem tanto para o aluno quanto para o professor. A pesquisa, de abordagem narrativa, culminou na defesa de valorização material e imaterial dos professores, explorando indícios que interferem no trabalho coletivo e no coletivo de trabalho e evidenciando crenças e valores desenvolvidos durante o processo de formação profissional com o PNAIC.Jane Maria Braga Silva; Reginaldo Fernando Carneiro

Work (physics); Context (archaeology); Field (mathematics); Power (physics); Subject (documents); Sociology; Humanities; Political science; Pedagogy

2026-01-01https://doi.org/10.1590/es.293795Educação & Sociedade 20261Beyond Hemostasis: Platelet Biomarkers and Vascular‐Immune Crosstalk in DengueDengue is an arboviral disease with major global public health impact. Its pathophysiology involves complex interactions between the virus and the host, including the immune response and the vascular endothelium. In this context, platelets play roles beyond hemostasis, acting as key immunomodulatory cells involved in inflammation and the regulation of vascular permeability. Therefore, this review summarizes and discusses the so called classic and non-classic platelet-related and endothelial biomarkers described in dengue virus infection. Classical biomarkers include P-selectin (CD62P), PF4/CXCL4, RANTES/CCL5, CD40L, IL-1β, VEGF, integrin αIIbβ3, CD63, and platelet extracellular vesicles, all supported by broad experimental and clinical evidence. Non-classical or emerging biomarkers include TLT-1, TREM-1/sTREM-1, angiopoietins (Ang-1/Ang-2), serotonin, ferritin, dengue virus envelope domain III (EIII), and soluble endothelial molecules such as IL-1RA, sCD163, SDC-1, sVCAM-1, IL-8, and IP-10. Alone or in combination, these markers can be used/explored as prognostic tools and/or as therapeutic targets. Finally, integrating multimarker panels encompassing hemostatic, inflammatory, and endothelial pathways may improve prognostic stratification. This approach could support targeted interventions and help reduce complications such as thrombocytopenia, plasma leakage, and dengue shock.Amanda Beatriz Adriano da Silva; Amanda de Oliveira Matos; Daniel Francisco de Sousa; Jefferson do Carmo Dietz; Eugênio D. Hottz; Marcelle Silva‐Sales; Helioswilton Sales‐Campos

Dengue fever; Dengue virus; Crosstalk; Microvesicles; Platelet; Immune system; Inflammation; Endothelial dysfunction; Medicine; Immunology; Disease; Platelet activation; Endothelium; Virus; Pathophysiology; Bioinformatics; Antibody-dependent enhancement; Endothelial activation; Cancer research

2026-06-22https://doi.org/10.1096/fj.202600884rrThe FASEB Journal 20261Landscape structure outweighs climate in shaping dietary composition of the maned wolf (Chrysocyon brachyurus, Illiger, 1815) across fragmented Atlantic Forest landscapesJean P. Silva¹²³; Lisandra Mendes Louzada-Camilo¹³; M. Fernandes¹³; Lênim Faber-Lopes¹; Pedro M. Villa¹³

Species richness; Biodiversity; Species evenness; Generalist and specialist species; Climate change; Environmental change; Trophic level; Forest structure; Ecology; Geography; Range (aeronautics); Abundance (ecology); Atlantic forest; Landscape ecology

2026-06-22https://doi.org/10.21203/rs.3.rs-9995593/v1Research Square 20261Persevering with the Family Health Strategy’s comprehensive community-based approachWe would like to thank the seven panelists -experienced managers and researchers -for their comments and reflections on our article 1 commemorating the 30th anniversary of the Family Health Strategy (FHS), which provides a critical analysis of its history, institutional and policy milestones and persistent challenges to fully implementing this community-based approach to primary health care (PHC) in the Brazilian Unified National Health System (SUS, acronym in Portuguese).Their comments offer additional insights and draw attention to relevant issues that enrich this debate.Lígia Giovanella; Maria Helena Magalhães de Mendonça; Estela Márcia Saraiva Campos; Ana Luíza Queiroz Vilasbôas; Rosana Aquino; Luiz Augusto Facchini

Qualitative research; Health care; Perspective (graphical); Family health; Public health; MEDLINE; Psychology; Medicine; Medical education

2026-01-01https://doi.org/10.1590/0102-311xen077226Cadernos de Saúde Pública 20261Conceptual evolution and methodological challenges of value-added in educational assessment: A scoping review 1971–2024Abstract Value-added (VA) models are widely used to evaluate educational effectiveness, yet their conceptual and methodological development remains insufficiently systematized. This study conducts a scoping review, complemented by an exploratory bibliometric analysis of studies published between 1971 and 2024, focusing on the seminal contributions of Hanushek (1971) in Education economics and Bryk and Weisberg (1976) in educational statistics. The findings reveal persistent gaps in the literature, notably the limited evidence from developing countries and the underexplored roles of school leadership and causal inference within VA frameworks. The review highlights a growing diversification of methodological approaches alongside an increasing alignment with accountability policies. From a policy perspective, the results underscore the need for context-sensitive VA applications, stronger school leadership, improved longitudinal data systems, and closer collaboration between researchers and policymakers to support more effective and equitable educational interventions.Kelly Alice Barbosa Macêdo; Maria Eugénia Ferrão; Marcel de Toledo Vieira

Accountability; Conceptual framework; Educational research; Causal inference; Exploratory research; Comparative education; Exploratory analysis; Conceptual model; Sociology; Political science; Management science; Engineering ethics; Policy analysis

2026-01-01https://doi.org/10.1590/s0104-40362026003405125Ensaio Avaliação e Políticas Públicas em Educação 20261Intention to leave work among nursing professionals at three university hospitals in BrazilOBJECTIVES: to analyze factors associated with intention to leave work among nursing professionals at three federal university hospitals in Brazil. METHODS: this was a cross-sectional multicenter study. Data were collected between October 2018 and September 2022, including personal and work-related data, job satisfaction, and intention to leave work. Chi-square, Mann-Whitney, and logistic regression tests were used. RESULTS: the study included 429 nursing professionals with a mean age of 38.9 years, predominantly female (80%), and nursing technicians (66.2%). Those with higher education or graduate education showed a greater intention to leave their jobs (p=0.029), dissatisfied with their job (p<0.001), who considered staff size inadequate (p=0.026), younger (p=0.014) and with less experience (p=0.046). Low job satisfaction was associated with a three times greater likelihood of leaving the job (OR=3.519; CI=1.594-7.766; p=0.002). CONCLUSIONS: dissatisfied nursing professionals are more likely to intend to leave their jobs.Hérica Silva Dutra; Diego Marques de Oliveira; Adrize Rutz Porto; Maria Cristina Soares Rodrigues; Diana Albuquerque Alvim de Paula; Paula Roberta Silva Araújo; Lucas da Silva Dellalibera; Nádia Fontoura Sanhudo

Logistic regression; Job satisfaction; Work (physics); University hospital; Nurse education; Work experience; Job dissatisfaction; Nursing; Psychology; Medicine; Nursing staff; Family medicine

2026-01-01https://doi.org/10.1590/0034-7167-2025-0192Revista Brasileira de Enfermagem 20261ADAPT Project: Perception and expectations of families regarding motorized mobility - a qualitative studyABSTRACT Motorized toy cars are viable devices for the exposure of children with disabilities to self-directed mobility as an option of lower cost and greater accessibility when compared to adapted locomotion equipment. This study aimed to know the perception and expectations of families of the ADAPT Project regarding motorized mobility. Nine mothers of the children enrolled in the ADAPT Project who agreed to participate in this qualitative study responded to a semi-structured qualitative interview by video call. The interviews were recorded and transcribed in full and were coded via content analysis. As a result, most children were diagnosed with cerebral palsy and had mean age of 2.7 years (SD:1.24). Most mothers were unaware of negative points related to the use of motorized cars for mobility. When asked about the positive points related to the early use of motorized mobility, three major themes arose from the interviews: development, inclusion, and autonomy and independence. Family expectations and perceptions about the use of motorized mobility within the scope of the ADAPT Project are legitimate and feasible according to the literature. The use of a motorized and individually adapted toy car can contribute to the development, inclusion, and autonomy and independence of these children.Larissa Ferraz de Souza; Letícia Ribeiro Diogo; Michele de Almeida Alvim; Maritza Breder; Livia Coutinho; Paula Silva de Carvalho Chagas

Qualitative research; Autonomy; Perception; Cerebral palsy; Scope (computer science); Independence (probability theory); Psychology; Applied psychology; Developmental psychology; Social psychology

2026-01-01https://doi.org/10.1590/1809-2950/e24002726enFisioterapia e Pesquisa 20261Disease Activity and Mental Health Assessment in Rheumatoid Arthritis and Systemic Lupus Erythematosus with and Without Covid-19: Five-Year Multicenter StudyMarco Felipe Macêdo Alves; Sally de França Lacerda Pinheiro; Adriana María Kakehasi; Gilda Aparecida Ferreira; Isabela Paes de Sá Machado; João Pedro Belo Osório Salzano Lago; Lílian David de Azevedo Valadares; Gabriel Eduardo Grave; Leonardo Peterson dos Santos; Odirlei André Monticielo; Ricardo Machado Xavier; Rafael Nazaro Cassar Camargo; Nafice Costa Araújo; Sandra Lúcia Euzébio Ribeiro; Viviane Angelina de Souza; Angélica Vilela Rodrigues de ALVARENGA; Luiz Gustavo Chaves Gomes; Lícia Maria Henrique da Mota; Ana Paula Monteiro Gomides Reis; Edgard Torres dos Reis Neto; Gecilmara Salviato Pilegii; M. Pinheiro; Cláudia Diniz Lopes Marques

Rheumatoid arthritis; Disease; Exacerbation; Confounding; Epidemiology; Systemic lupus erythematosus; Comorbidity; Lupus erythematosus; Medicine; Internal medicine; Immunology; Anxiety; Severity of illness; Arthritis; Rheumatology; Autoimmune disease; Connective tissue disease

2026-06-22https://doi.org/10.21203/rs.3.rs-9053192/v1Research Square 20261Floristic composition and similarity of a Ferruginous complex within the Iron Quadrangle, Minas Gerais, BrazilAbstract The present study presents species richness for the flora in the ferruginous campo rupestre of the Serra do Pires, located south of the Iron Quadrangle in the state of Minas Gerais, a region under strong threat by mining exploration. The area is composed of a complex of submontane semideciduous seasonal forests and ferruginous fields with distinct vegetation types, where campo limpo and campo sujo are predominant, alongside itabirite boulders and cangas. We found 484 vascular plant species, distributed in 309 genera and 98 families. Eighteen species are endemic to the Iron Quadrangle, and 26 have some endangered status. Herbaceous habit is predominant, found in 257 species (49%), reflecting the expressiveness of ferruginous fields in the area. We also compared the floristic composition of the study area with five other areas with similar vegetation located in the Iron Quadrangle. Similarity analysis revealed a reduced sharing of species between the areas compared. The results point to a complex and unique floristic composition of the Serra do Pires, with many endemic species and taxa still unknown to science, spread over unique environments. Our discussion underlines the inadequacy of the current conservation strategies and suggests the urgent need for more robust and specific public policies for the protection of these environments, considering their high biological diversity and the imminent risk imposed by mining.João Luís Lobo Monteiro de Castro; Henrique Migliorini Claudino; Luiz Menini Neto; Ana Paula Gelli de Faria; Fátima Regina Gonçalves Salimena

Floristics; Species richness; Vegetation (pathology); Flora (microbiology); Endemism; Taxon; Endangered species; Geography; Ecology; Habit; Nature reserve; Herbaceous plant; Similarity (geometry); Species diversity; Composition (language)

2026-01-01https://doi.org/10.1590/1676-0611-bn-2025-1846Biota Neotropica 2026130 anos da Estratégia Saúde da Família no Sistema Único de Saúde: marcos, avanços, retrocessos e desafiosEnsaio sobre a trajetória e desafios persistentes da Estratégia Saúde da Família (ESF) no Brasil, a partir de inquietações quanto às perspectivas para plena implementação desta abordagem de atenção primária à saúde de base territorial e orientação comunitária no Sistema Único de Saúde (SUS). Examina a trajetória de expansão e revisita criticamente os principais marcos institucionais da ESF nestes 30 anos, destacando a indução financeira federal associada ao processo de municipalização; ampliação da mutiprofissionalidade no trabalho desenvolvido nas unidades básicas de saúde (UBS) e territórios; indução da qualidade articulada à avaliação da estrutura e processo das equipes e transferências financeiras associadas ao desempenho; e provimento emergencial de médicos em áreas desassistidas, associado à formação profissional. Sintetiza repercussões da expansão da cobertura da ESF e da adoção de práticas centradas em pessoas, famílias e comunidades sobre a saúde e o acesso. Retrocessos, entre 2016 e 2022, com restrições à multiprofissionalidade abordagem comunitária e ameaças à universalidade e integralidade são abordados criticamente, bem como a retomada, pelo Governo Federal, da prioridade para a ESF a partir de 2023. Dados do Censo Nacional das UBS 2024 ilustram a situação atual resultante desta trajetória. Na análise dos desafios para a efetiva mudança no modelo assistencial e universalização da ESF, destaca-se suficiência do financiamento; estabilidade funcional, formação e trabalho colaborativo interprofissional; os riscos de mercantilização na atenção primária à saúde (APS); coordenação do cuidado e rol da APS na regulação assistencial e; as desigualdades geográficas, sociais e étnico-raciais no acesso.Lígia Giovanella; Maria Helena Magalhães de Mendonça; Estela Márcia Saraiva Campos; Ana Luíza Queiroz Vilasbôas; Rosana Aquino; Luiz Augusto Facchini

Work (physics); Government (linguistics); Process (computing); E-Government; Service (business); Political science; Humanities; Business

2026-01-01https://doi.org/10.1590/0102-311xpt206025Cadernos de Saúde Pública 20261Intenção de deixar o emprego entre profissionais de enfermagem de três hospitais universitários do BrasilRESUMO Objetivos: analisar fatores associados à intenção de deixar o emprego entre profissionais de enfermagem em três hospitais universitários federais do Brasil. Métodos: estudo multicêntrico transversal. Coletaram-se dados entre outubro/2018 e setembro/2022, incluindo dados pessoais e laborais, satisfação com o cargo, e intenção de deixar o emprego. Foram utilizados os testes qui-quadrado, Mann-Whitney e regressão logística. Resultados: participaram 429 profissionais de enfermagem com idade média de 38,9 anos, predominantemente do sexo feminino (80%), técnicos de enfermagem (66,2%). Apresentaram maior intenção de deixar o emprego aqueles com formação em nível superior ou pós-graduação (p=0,029), insatisfeitos com o emprego (p<0,001), que consideravam quantitativo da equipe inadequado (p=0,026), mais jovens (p=0,014) e com menor tempo de experiência (p=0,046). A baixa satisfação com o cargo foi associada com três vezes maior chance de deixar o emprego (OR=3,519; IC=1,594-7,766; p=0,002). Conclusões: profissionais de enfermagem insatisfeitos têm maior chance de intenção de deixar o emprego.Hérica Silva Dutra; Diego Marques de Oliveira; Adrize Rutz Porto; Maria Cristina Soares Rodrigues; Diana Albuquerque Alvim de Paula; Paula Roberta Silva Araújo; Lucas da Silva Dellalibera; Nádia Fontoura Sanhudo

Research methodology; Open access journal; Work (physics); Political science; Psychology

2026-01-01https://doi.org/10.1590/0034-7167-2025-0192ptRevista Brasileira de Enfermagem 20261Gabapentinoid Use and Risk of Alzheimer’s Disease-Related Dementias: A Systematic Review and Meta-analysis of Observational StudiesAnderson Matheus Pereira da Silva; Marianna Leite; Giovana Menegucci; Maria Fernanda Liphaus Almeida Negreli; María Eugenia López Valverde; Isabelle Rodrigues Menezes; Ocílio Ribeiro Gonçalves; Jorge Dornellys da Silva Lapa; G Noleto; Diogo Haddad Santos; Filipe Silveira Duarte; George Perry; Eryvelton de Souza Franco; Maria Bernadete de Sousa Maia

Observational study; Odds ratio; Confounding; Gabapentin; Meta-analysis; Confidence interval; Randomized controlled trial; Cohort study; Relative risk; Cochrane Library; Medicine; Systematic review; Odds; MEDLINE; Pregabalin; Absolute risk reduction; Prospective cohort study; Dementia; Subgroup analysis; Internal medicine; Risk factor; Discontinuation

2026-06-22https://doi.org/10.1007/s40266-026-01310-zDrugs & Aging 20261Projeto ADAPT: Percepção e expectativas das famílias em relação à mobilidade motorizada - um estudo qualitativoRESUMO Carros de brinquedo motorizados são dispositivos viáveis para a exposição precoce de crianças com deficiência à mobilidade autodirigida, como uma opção de menor custo e maior acessibilidade quando comparados a equipamentos de locomoção adaptados. O objetivo deste estudo qualitativo foi conhecer a percepção e expectativas das famílias do Projeto ADAPT em relação à mobilidade motorizada. Participaram nove mães de crianças inscritas no Projeto ADAPT, que aceitaram responder a uma entrevista qualitativa semiestruturada realizada por videochamada. As entrevistas foram gravadas e transcritas integralmente, e codificadas por meio de análise de conteúdo. Como resultados, a maioria das crianças tinham paralisia cerebral, com idade média de 2,7 anos (DP:1,24). Grande parte das mães respondeu que desconhecia pontos negativos ligados ao uso do carrinho motorizado como opção para mobilidade. Quando questionadas sobre os pontos positivos relacionados ao uso precoce da mobilidade motorizada, três grandes temas surgiram das entrevistas: desenvolvimento, inclusão, e autonomia e independência. As expectativas e percepções familiares sobre o uso da mobilidade motorizada no âmbito do Projeto ADAPT são legítimas e factíveis de acordo com a literatura. O uso do carro de brinquedo motorizado e adaptado individualmente pode contribuir para desenvolvimento, inclusão e autonomia e independência dessas crianças.Larissa Ferraz de Souza; Letícia Ribeiro Diogo; Michele de Almeida Alvim; Maritza Breder; Livia Coutinho; Paula Silva de Carvalho Chagas

Autonomy; Qualitative research; Thematic analysis; Exploratory research; Humanities; Computer science; Sociology

2026-01-01https://doi.org/10.1590/1809-2950/e24002726ptFisioterapia e Pesquisa 20261Limnological tools to improve water transparency management in semi-intensive cultures of Oreochromis niloticusThe aim of this study was to evaluate the relationships among water quality variables and Secchi disk transparency in semi-intensive Oreochromis niloticus earthen ponds. A total of 38 water samples were taken from 27 O. niloticus culture ponds located in rural villages in Brazil, using a non-probabilistic convenience sampling approach. The main water quality variables analyzed included transparency, chlorophyll- a , total suspended solids (TSS), inorganic solids (IS), and volatile solids (VS). The results demonstrated that Chl a ( p -value = 0.04), TSS ( p -value = 0.002), IS ( p -value = 0.02), and VS ( p -value = 0.04) had a significantly increasing trend with decreasing pond Secchi disk transparency. These findings indicated that the low water transparency readings were not caused solely by system’s primary production This was confirmed by the high percentage of IS in the TSS (&gt; 60%), reinforcing the idea that solids in the water were composed of mineral particles such as sand, silt, and clay. This behavior could be caused by wind or bioturbation by O. niloticus , which causes sediment from the bottom of the pond to be carried into the water column, reducing water transparency. These findings demonstrated that water transparency was not directly related to pond primary production. Therefore, relying solely on Secchi disk depth, as commonly practiced, may not be sufficient for managing eutrophication in semi-intensive O. niloticus farming through water exchange. These results highlight the importance of accurately interpreting water transparency to support more effective environmental management, reduce potential stressors, and contribute to improved animal welfare in these farming systems.Otávio Augusto Lacerda Ferreira Pimentel; Deusimar Freire Brasil; Marcos R. Camara; Ng Haig They; André Megali Amado

Secchi disk; Oreochromis; Water quality; Total suspended solids; Eutrophication; Sediment; Total dissolved solids; Water column; Suspended solids; Environmental science; Fishery; Environmental engineering; Hydrology (agriculture); Aquaculture; Water level; Fish farming; Surface water; Transparency (behavior); Nutrient; Ecology; Water treatment; Water use; Water pollution; Sewage

2026-06-22https://doi.org/10.3389/faquc.2026.1835992Frontiers in Aquaculture 20261Perseverar na abordagem integral comunitária da Estratégia Saúde da FamíliaLígia Giovanella; Maria Helena Magalhães de Mendonça; Estela Márcia Saraiva Campos; Ana Luíza Queiroz Vilasbôas; Rosana Aquino; Luiz Augusto Facchini

Calculus (dental); Set (abstract data type); Measure (data warehouse); Stability (learning theory); Point (geometry); Mathematics; Computer science

2026-01-01https://doi.org/10.1590/0102-311xpt077226Cadernos de Saúde Pública 20261Hydroalcoholic Extract from Lantana camara Leaves: Phytochemical Composition and In Vitro Antioxidant and Anti-Inflammatory ActivitiesAbstract Lantana camara L. (Verbenaceae) is widely used in traditional medicine to treat wounds, inflammatory conditions, and microbial infections, owing to its phytochemical composition, which includes flavonoids, phenolic acids, and triterpenes, known for their associated antioxidant and anti-inflammatory properties. However, scientific studies exploring its pharmacological potential, particularly for inflammatory skin disorders, remain limited. This study aimed to evaluate the antioxidant and anti-inflammatory activities hydroalcoholic extract from L. camara leaves (LCHA) and characterize its phytochemical composition to support its potential therapeutic applications. Quantitative assays were performed to determine total phenolic, terpene, and saponin contents, while the phytochemical profile of LCHA was elucidated using UFLC-QTOF-MS, revealing the presence of lamiide, geniposide, pectolinarin, luteolin-7-O-glucoside, and rhamnocitrin-O-glucoside. In vitro assays were conducted using peritoneal macrophages and L929 fibroblasts to assess cell viability and to evaluate anti-inflammatory activity through nitric oxide (NO) production and lipid body accumulation. Antioxidant activity was determined via DPPH radical scavenging, phosphomolybdenum reduction, β-carotene/linoleic acid system, and reactive oxygen species (ROS) quantification. LCHA significantly inhibited NO production (100% at the highest concentration) and reduced lipid body formation by 68.61% in macrophages. Moreover, LCHA demonstrated notable antioxidant capacity, including 41.94% inhibition of lipid peroxidation and a 65.05% reduction in ROS levels in activated macrophages. These findings support its traditional use and highlight its potential as a plant-based therapeutic alternative for inflammatory skin disorders, encouraging its further investigation.Natasha Silva Mayrink; Gianluigi Lazzarini; Ari Sérgio de Oliveira Lemos; Elaine Soares Coimbra; Rodrigo Luiz Fabri

Phytochemical; Antioxidant; Lantana camara; DPPH; Saponin; Reactive oxygen species; Lipid peroxidation; Nitric oxide; Chemistry; Traditional medicine; Anti-inflammatory; In vitro; Biochemistry; In vitro toxicology; Oxygen radical absorbance capacity; Pharmacology

2026-01-01https://doi.org/10.1590/1678-4324-2026250562Brazilian Archives of Biology and Technology 20261Climate Mediates Land-use and Within-lake Drivers of Seston Stoichiometry: A Large-scale Assessment Across Tropical Shallow LakesAdriano Soares Mota; Regina L. G. Nobre; Camila Rodrigues Cabral; Letícia Barbosa Quesado; Rafael Dettogni Guariento; André Megali Amado; Luciana S. Carneiro; Adriano Caliman

Seston; Precipitation; Phosphorus; Ecosystem; Aquatic ecosystem; Nutrient; Drainage basin; Lake ecosystem; Hydrology (agriculture); Environmental science; Ecology; Nutrient cycle; Climate change; Freshwater ecosystem; Particulates; Water column; Terrestrial ecosystem; Phytoplankton; Dissolved organic carbon; Biogeochemistry

2026-06-23https://doi.org/10.21203/rs.3.rs-10057861/v1Research Square 20261A Framework to Assess the Influence of Different Cardiac Fibrosis Phenotypes and Border Zone on ArrhythmogenesisCurrent computational models often oversimplify cardiac fibrosis, lacking micro-architecture details. To address this, we present a scalable computational pipeline extending a histologically-calibrated Perlin noise generator to automatically construct focal fibrotic cores and functional border zones. Using this framework, we conducted preliminary 2D electrophysiological simulations under localized hypoxia to evaluate four distinct phenotypes. Initial results suggest that phenotype influences tissue vulnerability, with diffuse architectures exhibiting a higher incidence of reentries under the tested conditions. Furthermore, the framework successfully models geometrically constrained lesions, highlighting that variations in the total diseased area between global and focal models substantially alter the number of arrhythmic events. This work underscores the importance of incorporating spatial heterogeneity and appropriate boundary constraints in predictive computational modeling.Guilherme M. Couto; Joventido O. Campos; Rodrigo W. dos Santos

Pipeline (software); Computational model; Border zone; Cardiac fibrosis; Phenotype; Fibrosis; Cardiac electrophysiology; Computational simulation; Hypoxia (environmental); Medicine; Diffusion MRI; Cardiology; Cardiac imaging; Computer science; Neuroscience; Internal medicine; Pathology; Noise (video); Work (physics)

2026-06-01https://doi.org/10.5753/sbcas.2026.21656 20261Support for a Chat-Based Intervention to Reduce Alcohol Consumption via Emotion DetectionHarmful alcohol consumption constitutes a public health problem associated with social and health impacts. Chat-based interventions conducted by psychologists emerge as an alternative to reduce the harm caused by alcohol, and text emotion detection can support professionals with additional information. It is expected that identifying emotions will allow consultants to monitor the patient’s emotional state, facilitating more sensitive interventions. Thus, this work evaluates three datasets and five emotion classification models, aiming to provide a basis for the implementation of the service. The TweetEmotions, PlayStoreReviews, and GoEmotions datasets were analyzed, along with Logistic Regression, LinearSVC, Random Forest, XGBoost, and an adjusted BERTimbaubase model, as well as different preprocessing, balancing, and feature engineering strategies. The GoEmotions dataset proved to be the most suitable for the proposed scenario due to its multi-label characteristic. The results indicate consistent performance, with a macro F1-score of 0.40, making it possible to offer professionals an additional resource to support decision-making and contribute to better-targeted care and improved quality of support.Luan Henrique da S. Barbosa; Heder S. Bernardino

Psychological intervention; Harm; Intervention (counseling); Alcohol consumption; Quality (philosophy); Feature (linguistics); Brief intervention; Health care; Psychology; Applied psychology; Computer science; Resource (disambiguation); Consumption (sociology); Affect (linguistics); Social support; Macro; Health professionals; Clinical psychology; Public health

2026-06-01https://doi.org/10.5753/sbcas.2026.21291 20261Pacing analysis in off-road running: a narrative review of methods, metrics, and performance implicationsOff-road running (ORR) includes trail running, mountain running, skyrunning, and ultra-trail events performed in heterogeneous outdoor environments, where pacing is influenced by terrain, elevation, technicality, and race duration. This narrative review aimed to critically summarise pacing-analysis methods, data sources, and pacing-related performance metrics used in ORR studies. A structured PubMed search was conducted on 1 June 2026 using Title/Abstract terms related to ORR disciplines, pacing, race analysis, speed, performance metrics, GPS, and wearable data. The search retrieved 226 records for screening. After title-based screening and refinement according to pacing-specific eligibility criteria, 72 candidate studies were assessed, resulting in 11 core studies included in the narrative synthesis. The included studies used heterogeneous but complementary approaches, including official race results, split times, checkpoint data, Strava® segments, sport-watch files, experimental field data, terrain-adjusted models, and running-power metrics. Pacing was commonly quantified using segmental speed, checkpoint speed, relative pace, coefficient of variation of speed or pace, relative section speed, grade-adjusted speed, weighted time adjusted for terrain difficulty, and power-based intensity distribution. Overall, the evidence suggests that pacing in ORR reflects context-sensitive regulation of effort across terrain-specific and race-stage demands. Future ORR performance analysis should integrate race-level outcomes, terrain-specific segmentation, wearable-derived metrics, and field-based assessments.Rodney Coelho da Paixão; Moacir Marocolo

Narrative; Narrative review; Race (biology); Field (mathematics); Terrain; Computer science; Medicine; Variation (astronomy)

2026-06-23https://doi.org/10.52641/cadcajv11i7.3240Cadernos Cajuína 20261Free-ranging dogs as drivers of wildlife disturbance in an urban Atlantic Forest remnant.Luana S Gonçalves; Jean Pablo Alves de Deus; Carolina Antunes Ribeiro; Ribeiro; Fábio Prezoto; C. R. Dickman; Aline Cristina Sant’Anna

Wildlife; Biodiversity; Species richness; Wildlife conservation; Disturbance (geology); Wildlife management; Population; Camera trap; Geography; Ecology; Urban ecology; Atlantic forest; Nature reserve

2026-06-23https://doi.org/10.21203/rs.3.rs-9973036/v1Research Square 20261Modelagem da Duração do Potencial de Ação em Tecido Cardíaco Utilizando Curvas e Superfícies de RestituiçãoA duração do potencial de ação (APD) desempenha papel fundamental na dinâmica elétrica do tecido cardíaco. Neste trabalho, foram investigados dois métodos para a predição do APD: curva de restituição ajustada em função do intervalo diastólico (DI) e superfície de restituição que incorpora o histórico de estimulação, considerando DI e ciclo básico (BCL) dos dois últimos estímulos. Um autômato celular foi desenvolvido para simular a propagação da ativação elétrica no tecido e avaliar os modelos. Os resultados indicam que o modelo baseado em superfície de restituição reproduz com maior precisão o comportamento observado nas simulações biofísicas.Thaís de Jesus Soares; Joventino de Oliveira Campos; Rodrigo Weber dos Santos

Work (physics); Constant (computer programming); Acceleration; Isothermal process; Physics

2026-06-01https://doi.org/10.5753/sbcas.2026.21688 20261Speeding up Cardiac Digital Twinning using a GPU-based Eikonal SolverCardiac digital twins are patient-specific computational models that enable personalized diagnosis and treatment planning. A fundamental step in their construction is the simulation of electrical activation in the myocardium, commonly approximated using Eikonal-based propagation models. However, repeatedly solving the Eikonal equation can become a computational bottleneck during the personalization process. In this work we investigate the use of a GPU-based Fast Iterative Method (FIM) solver to accelerate the computation of cardiac activation maps in the digital twin pipeline. Preliminary results show a reduction in execution time, achieving a speedup of approximately 1.7× compared to a CPU solver, while preserving activation patterns and ECG morphology when compared to clinical data.Augusto de Filippo Cavalini; Rodrigo Weber dos Santos; Lucas Arantes Berg

Eikonal equation; Solver; Bottleneck; Fast marching method; Speedup; Computation; Reduction (mathematics); Bidomain model; Computer science; Algorithm; Computational science; Computational complexity theory; Central processing unit; Work (physics); Parallel computing; Mathematical optimization; Breakup; Applied mathematics

2026-06-01https://doi.org/10.5753/sbcas.2026.21674 20261Postoperative cystoid macular edema after pars plana vitrectomy for epiretinal membrane: incidence, anatomical and functional outcomes, and response to intravitreal dexamethasone implantBACKGROUND: To determine the incidence of postoperative cystoid macular edema (CME) following pars plana vitrectomy (PPV) with epiretinal membrane (ERM) peeling, and to evaluate the anatomical and functional response to intravitreal dexamethasone implant (Ozurdex; AbbVie) in affected eyes. METHODS: This retrospective, single-center cohort study included 92 consecutive eyes with idiopathic ERM that underwent PPV with ERM peeling by a single surgeon. Eyes were allocated to a control group (n = 84), comprising eyes without postoperative CME, or to a CME group (n = 8), comprising eyes that developed postoperative CME confirmed on swept-source optical coherence tomography (SS-OCT) and subsequently received intravitreal dexamethasone implant (DEX). Best-corrected visual acuity (BCVA, logMAR), central macular thickness (CMT, µm), and intraocular pressure (IOP, mmHg) were assessed preoperatively and postoperatively in both groups, and before and after DEX implantation in the CME group. RESULTS: The incidence of postoperative CME requiring treatment was 8.7%. Most baseline characteristics were comparable between groups, although preoperative IOP was significantly lower in the CME group. CMT decreased significantly after surgery in both the control group (335.1 ± 37.3 to 289.5 ± 22.9 μm; p < 0.001) and the CME group (382.9 ± 74.6 to 310.9 ± 22.9 μm; p = 0.033); however, postoperative CMT remained significantly higher in the CME group than in controls (p = 0.034). DEX implantation produced an additional significant CMT reduction (379.9 ± 67.1 to 302.7 ± 35.3 μm; p = 0.003), reducing the between-group difference to a non-significant level (p = 0.332). BCVA improved significantly after surgery in the control group (0.32 ± 0.26 to 0.04 ± 0.10 logMAR; p < 0.001) but not in the CME group (p = 0.582). Following DEX implantation, BCVA improved significantly in the CME group (0.47 ± 0.35 to 0.22 ± 0.25 logMAR; p = 0.002), approaching values observed in the control group (p = 0.078). IOP remained stable in controls (p = 0.576). A transient but significant IOP increase was observed in the CME group after surgery (11.5 ± 2.7 to 15.3 ± 3.7 mmHg; p = 0.019), with no further change after DEX implantation (p = 0.747). CONCLUSIONS: Postoperative CME requiring treatment occurred in approximately 1 in 11 eyes following PPV with ERM peeling and was associated with significant anatomical and functional impairment. The present findings suggest that intravitreal dexamethasone implant was associated with improvement in selected cases of postoperative CME without additional impact on IOP; however, larger prospective studies are required to confirm these results.Leonardo Provetti Cunha; Manuela Ferreira Guimarães; Leandro Cabral Zacharias; Rony Carlos Preti; Luciana Virgínia Ferreira Costa-Cunha; M L R Monteiro

Pars plana; Vitrectomy; Macular edema; Dexamethasone; Visual acuity; Epiretinal membrane; Implant; Medicine; Ophthalmology; Intraocular pressure; Incidence (geometry); Significant difference; Surgery; Complication

2026-06-23https://doi.org/10.1186/s40942-026-00888-1International Journal of Retina and Vitreous 20261Cerrado plant traits (CPT): a database of functional traits across vegetation types in a global biodiversity hotspotBACKGROUND: Trait-based ecology has become central for understanding plant form, function and ecosystem processes, but progress has been hampered by biased representation in trait databases. As such, global trait syntheses remain strongly biased towards temperate forest biomes. Tropical savannas are the most extensive, biodiverse and disturbance-driven ecosystems worldwide, yet are poorly represented in functional trait databases, limiting ecological inference and applied decision-making. SCOPE: Here, we introduce the Cerrado Plant Traits (CPT), an open-access initiative compiling and standardising plant functional trait data for the Brazilian Cerrado, the world's most biodiverse tropical savanna. CPT integrates trait information for all major plant organs (whole-plant, root, shoot, leaf, flower, fruit and seed) across vegetation types in the Cerrado, drawing on a collaborative and inclusive research network. The current version of CPT compiles data from 148 datasets, totalling 113,859 curated trait records for 2,134 taxonomically verified species across 150 families. Trait records span pristine, degraded and restored environments and capture both interspecific and intraspecific variation. Whole-plant and leaf traits dominate the current dataset, while belowground and reproductive traits remain comparatively underrepresented, highlighting key priorities for future research. CONCLUSIONS: By substantially increasing the representation of savanna species in global trait repositories, CPT enables tests of ecological hypotheses across multiple levels of organization, analyses of trait-environment relationships across fire, soil and climatic gradients, and robust comparisons across forest-savanna transitions. Beyond its scientific value, CPT provides a practical, standardised resource to support conservation planning, restoration programs and evidence-based policy in a biodiversity hotspot facing accelerating land-use and climate pressures.Lara Amaral-Garcia; Carlos A. Ordóñez‐Parra; Kayna Agostini; Luiz G. Barbosa‐Dias; Alessandra Fidelis; Pietro K. Maruyama; Natália F. Medeiros; Norma Senna; Davi Rodrigo Rossatto; Pablo H A Melo; Dayana Figueiredo Abdalla; Ludmilla M S Aguiar; Viviane O. Almeida; Maria Júlia Oliveira Alves; Marsal D. Amorim; Lidyanne Y S Aona; Andre Jardim Arruda; André D Azevedo Neto; Caio S. Ballarin; Milton Barbosa; Ricardo L L Berbara; Eduardo van den Berg; P Bergamo; Paulo N. Bernardino; Aline Bertolosi Bombo; Cleusa Bona; Renan Borgiani; Denilson R V Branco; Adriano A Brito-Darosci; Maria G G Camargo; Liliane Santos de Camargos; Mariana Lopes Campagnoli; Bruna H Campos; João C F Cardoso; M L Carlucci; João V P Carreri; I R B Carvalho; Vanessa Carvalho; Mário G B Cava; Gregório Ceccantini; Constance Chassagne; Ana Luisa A Chaves; Marco Antônio Chiminazzo; Alexander V. Christianini; Marcus Vinícius Cianciaruso; Rosane G Collevatti; Hélder Consolaro; Grênivel Mota da Costa; Bruno Bonadio Cozin; Claudineia Pelacani Cruz; L. Felipe Daibes; Mariana Dairel; Andra Carolina Dalbeto; Gabriella Damasceno; Vinícius Dantas; R Dayrell; Gabriela Dezotti; Luiz Eduardo Dias; Ugo Mendes Diniz; Sara Stefani Domingos; Beatriz Silvério dos Santos; Edson Ferreira Duarte; Giselda Durigan; Diego Fernando Escobar; Renato Feliciano; Geraldo W Fernandes; Bruno H S Ferreira; Heleno Dias Ferreira; Maurílio Assis Figueiredo; Hudson G V Fontenele; Augusto C. Franco; Camila T R Freire; Letícia Couto Garcia; R Gasparini; Irene Gélvez‐Zúñiga; Ingrid N. Gomes; Lhoraynne Pereira Gomes; Marina Efigenia Gonçalves; Maria Tereza Grombone-Guaratini; Murilo Menck Guimarães; Alessandro Dias Halfeld; Marina Hirota; Laís Lima Jacconi; Raissa I L Jardim; João Carlos F Melo Júnior; Vera L G Klein; Rosana Marta Kolb; Alessandra Rodrigues Kozovits; Soizig Le Stradic; Priscilla de Paula Loiola; Stephanie Lopes; Renata A Maia; Leandro Maracahipes; Vanessa Mariano; Rafaela Cabral Marinho; Aline Redondo Martins; Amanda Eburneo Martins; de Mattos Gr; Nayara M J Melo; Clesnan Mendes‐Rodrigues

Trait; Biodiversity; Ecosystem; Biodiversity hotspot; Temperate forest; Functional ecology; Taxon; Temperate climate; Intraspecific competition; Biology; Ecology; Limiting; Tropics; Ecosystem services; Global change; Vegetation (pathology); Interspecific competition; Tropical forest; Spatial ecology; Species richness

2026-06-23https://doi.org/10.1093/aob/mcag176Annals of Botany 20261Estimativa de parâmetros constitutivos da mecânica cardíaca em alta resolução com cálculo de gradientes via método adjuntoEste trabalho investiga a estimativa de parâmetros constitutivos da mecânica cardíaca em alta resolução, tendo em vista condições como a cardiomiopatia dilatada e na fibrose miocárdica. O problema é formulado como um problema inverso para estimar um parâmetro constitutivo da rigidez do tecido utilizando o método adjunto para o cálculo eficiente do gradiente do funcional custo. São avaliadas diferentes formulações do funcional de dados, baseadas nos deslocamentos e no tensor gradiente de deformação. Dois cenários sintéticos são considerados: um com distribuição suave e outro com distribuição descontínua da rigidez. Os resultados indicam melhor desempenho quando o funcional de dados é baseado no gradiente de deformação. O parâmetro de regularização controla o compromisso entre ajuste aos dados, suavização da solução e custo computacional.Jorge G. B. Tohalino; Joventino O. Campos; Rodrigo W. dos Santos; Bernardo M. Rocha

Work (physics); Context (archaeology); Balance (ability); Quadratic equation

2026-06-01https://doi.org/10.5753/sbcas.2026.20538 20261IMPACTO DA EDUCAÇÃO CONTINUADA NA QUALIDADE DO ENSINOEste artigo analisa o impacto da educação continuada na qualidade do ensino, com foco na formação permanente de professores da educação básica brasileira. Parte-se da compreensão de que ensinar, hoje, não é repetir fórmulas prontas, mas reelaborar práticas diante de estudantes reais, escolas desiguais, currículos em movimento e tecnologias que batem à porta da sala de aula. O objetivo geral é discutir de que modo a educação continuada contribui para a melhoria da prática pedagógica, da aprendizagem dos estudantes, da gestão da sala de aula, da avaliação e da valorização profissional docente. A metodologia adotada é bibliográfica e documental, baseada em fontes brasileiras, como legislação educacional, dados do Inep, estudos do Ipea, relatório do Todos Pela Educação e produção acadêmica nacional. Os resultados indicam que a educação continuada fortalece a qualidade do ensino quando está ligada às necessidades concretas da escola, ocorre de modo sistemático, valoriza a experiência docente, promove colaboração profissional e possui acompanhamento pedagógico. Conclui-se que a formação continuada não deve ser tratada como evento isolado, palestra solta ou obrigação burocrática, mas como política permanente de desenvolvimento profissional e de melhoria da educação pública e privada.Késia Nascimento da Cruz Rodolfo; Eduardo Damasceno Costa; Simone do Socorro Azevedo Lima; Marcos Antônio da Silva; Daniela Fiorini; Leandro José Michelon; Bárbara Maria Silva dos Santos; Ana Flávia Lima Pereira Araujo; Daniela Paula de Lima Nunes Malta; L da PG da Silva; Pedro Wilson Ramos da Conceição; Cristina Hill Fávero; Cinthia Raphaelle Schaumam de Paiva; Jéfferson Balbino

Continuing education; Quality (philosophy); Continuing professional development; Context (archaeology); Humanities; Philosophy

2026-06-23https://doi.org/10.70773/revistatopicos/782186822Revista Tópicos. 20261Modelagem Coronária Otimizada com Expoente Adaptativo de Bifurcação para Aplicações em Planejamento TerapêuticoModelos coronarianos gerados pelo algoritmo CCO utilizam tradicionalmente o expoente γ = 3 (Lei de Murray). Avaliamos o impacto de γ na fidelidade morfométrica frente a dados reais para planejamento terapêutico. Foram comparados γ = 3, γ = 2,55 e um modelo adaptativo dependente do fluxo relativo. O desempenho foi medido por RMSE logarítmico ponderado com penalização estrutural e IC95% via bootstrap. Observou-se redução do erro com γ = 2,55 e superioridade do modelo adaptativo (γprox = 2,85, β ≈ 2,0) ao capturar transições funcionais entre regimes proximais e distais. Estratégias adaptativas são fundamentais para gêmeos digitais coronarianos realistas, impactando a acurácia de simulações e o suporte à decisão clínica.Cristiano A. Matta; Pedro Henrique Correia Bezerra Silva; Bernardo M. Rocha; RAFAEL A.B. DE QUEIROZ

Control theory (sociology); Mathematics

2026-06-01https://doi.org/10.5753/sbcas.2026.21346 20261Dual drug release from Nanostructured Lipid Carriers promotes synergistic effects against melanoma cellsMelanoma is the most aggressive form of skin cancer, characterized by high metastatic potential, poor prognosis, and the frequent development of therapeutic resistance. Despite advances in therapeutic approaches, its incidence continues to increase, requiring continued investigation of new treatment strategies. Here we investigated how the dual release of drugs influences the synergistic cytotoxic potential of well-known drugs in melanoma. For that, resveratrol (RVT) and diclofenac sodium (DIC) were co-encapsulated in nanostructured lipid carriers (NLC). Firstly, the synergistic effect of RVT:DIC combination (RD) was evaluated in murine melanoma cells (B16F10 cell line). Then, NLC were developed to co-encapsulate both drugs. The nanostructures were characterized regarding their mean hydrodynamic diameter, polydispersity index (PDI), Zeta potential (ZP), pH, encapsulation efficiency (EE%), morphology, ATR-Fourier transform infrared spectroscopy (ATR-FTIR), Powder X ray diffraction (PXRD) and physicochemical stability. The cytotoxic activity, antioxidant activity and apoptosis of the combinatory treatment was evaluated in B16F10 and fibroblast (L929) cells. The combination of RVT and DIC showed cytotoxic synergism in the proportion of 2:1, respectively. The NLC exhibited a diameter of around 174 nm, PDI of 0.11, negative ZP, slightly acidic to neutral pH values, EE% > 90% and spherical morphology. The ATR-FTIR spectra revealed a change in the typical band profile of RVT and DIC after incorporation into nanostructures, which corroborates the encapsulation of the drugs. The same was observed for PXRD patterns. RD-loaded NLC enhanced the cytotoxic effect in melanoma cells compared to non-encapsulated RD. Most importantly, the nanocarriers did not alter the viability of fibroblasts, which indicates the specific cytotoxic effect against melanoma cells. Furthermore, RD-NLC promoted pro-oxidative and pro-apoptotic activity. Therefore, the co-encapsulation of RVT and DIC into NLC represents a promising approach for melanoma treatment by combining synergistic anticancer activity with selective cytotoxicity toward tumor cells. These findings support the potential of nanotechnology-enabled combination therapy as an alternative strategy to overcome current therapeutic limitations in melanoma.Natália Prado da Silva; Ana Beatriz Caribé dos Santos Valle; Lucas Cerqueira Avelar de Oliveira; Davi Trombini Aleixo; Paula Rocha Chellini; Antônio Carlos Sant’Ana; Alexandre Cuin; Sergio Moya; Guilherme Diniz Tavares; Frederico Pittella

Melanoma; Dual (grammatical number); Drug; Cytotoxicity; Drug carrier; Cell culture; Chemistry; Cancer research; Biophysics; Cell biology; Pharmacology; Biochemistry; Nanotechnology

2026-06-24https://doi.org/10.1016/j.jddst.2026.108644Journal of Drug Delivery Science and Technology 20261Public governance and creative economy dynamics: Towards an integrated conceptual understandingThe growing prominence of the creative economy in urban development and cultural policy has intensified debates on how public governance mediates economic, social and territorial change. Although public governance, the creative economy and tourism are increasingly intertwined in practice, academic research has often examined these domains through fragmented and sector-specific perspectives, treating governance as contextual rather than as a central analytical mechanism. Against this background, this study analyses how the academic literature addresses the relationship between public governance and the creative economy in urban and cultural contexts where tourism operates as a key field of application. It adopts an integrated, variable-oriented systematic review approach, combining structured literature screening with textual and conceptual analyses to enable a relational reading across governance, creative economy and tourism research. The findings show that these domains are mainly connected through policy-led frameworks shaping tourism-related urban development, sustainability strategies, social innovation and cultural dynamics. The literature also reveals a gradual shift towards participatory and multilevel governance models, alongside persistent challenges related to cultural instrumentalisation, precarious creative labour and fragile governance arrangements, particularly in urban settings. By providing a critical and integrated synthesis, this review advances debates on urban governance and creative policymaking globally.Daiane Estacio da Silva Tavares; Pablo Henrique de Oliveira Moreira; Carla Fraga; Joice Lavandoski; Lucília Cardoso

Corporate governance; Conceptual model; Creative economy; Conceptual framework; Public policy; Conceptual history; Economic system; Business; Political science; Public administration

2026-06-25https://doi.org/10.1016/j.ccs.2026.100732City Culture and Society 20261IMPACTO DA EDUCAÇÃO CONTINUADA NA QUALIDADE DO ENSINOEste artigo analisa o impacto da educação continuada na qualidade do ensino, com foco na formação permanente de professores da educação básica brasileira. Parte-se da compreensão de que ensinar, hoje, não é repetir fórmulas prontas, mas reelaborar práticas diante de estudantes reais, escolas desiguais, currículos em movimento e tecnologias que batem à porta da sala de aula. O objetivo geral é discutir de que modo a educação continuada contribui para a melhoria da prática pedagógica, da aprendizagem dos estudantes, da gestão da sala de aula, da avaliação e da valorização profissional docente. A metodologia adotada é bibliográfica e documental, baseada em fontes brasileiras, como legislação educacional, dados do Inep, estudos do Ipea, relatório do Todos Pela Educação e produção acadêmica nacional. Os resultados indicam que a educação continuada fortalece a qualidade do ensino quando está ligada às necessidades concretas da escola, ocorre de modo sistemático, valoriza a experiência docente, promove colaboração profissional e possui acompanhamento pedagógico. Conclui-se que a formação continuada não deve ser tratada como evento isolado, palestra solta ou obrigação burocrática, mas como política permanente de desenvolvimento profissional e de melhoria da educação pública e privada.Késia Nascimento da Cruz Rodolfo; Eduardo Damasceno Costa; Simone do Socorro Azevedo Lima; Marcos Antônio da Silva; Daniela Fiorini; Leandro José Michelon; Bárbara Maria Silva dos Santos; Ana Flávia Lima Pereira Araujo; Daniela Paula de Lima Nunes Malta; L da PG da Silva; Pedro Wilson Ramos da Conceição; Cristina Hill Fávero; Cinthia Raphaelle Schaumam de Paiva; Jéfferson Balbino

Continuing education; Quality (philosophy); Continuing professional development; Context (archaeology); Humanities; Philosophy

2026-06-23https://doi.org/10.70773/revistatopicos/782186823Revista Tópicos. 20261DT-CREATE: A Service Suite for Self-Adaptive Digital Twins Supporting Predictive Maintenance Decisions in Industry 5.0Izaque Esteves Da Silva; Regina Braga; José David; Victor Ströele

Suite; Predictive maintenance; Agile software development; Decision support system; Automation; Resilience (materials science); Predictive analytics; Industry 4.0; Computer science; Risk analysis (engineering); Process management; Software engineering; Service (business); Intelligent decision support system; Knowledge representation and reasoning; Software deployment; Systems engineering

2026-01-01https://doi.org/10.2139/ssrn.6989048SSRN Electronic Journal 20261A hybrid modeling approach for approximating the hydro unit commitment constraints in a large-scale day-ahead dispatch model in BrazilR. T. Figueiredo; David Lucas dos Santos Abreu; Erlon Cristian Finardi; Murilo Reolon Scuzziato; A.L.M. Marcato; G.F.da S. Pazdziorny

Economic dispatch; Representation (politics); Power system simulation; Hydroelectricity; Function (biology); Predictability; Computer science; Mathematical optimization; Production (economics); Unit (ring theory)

2026-06-01https://doi.org/10.1016/j.epsr.2026.113575Electric Power Systems Research 20261Peep, Squeal and Claim: Complex Territorial Call Emission Across Social Contexts in a Neotropical Torrent FrogABSTRACT Acoustic signals are central to torrent frog social behavior, and while sexual selection and adaptation to stream noise have been well studied through advertisement calls, territorial calls remain comparatively overlooked. We detailed the complex structure of male territorial calls of Hylodes perere (Anura: Hylodidae) in a protected area of the Atlantic Rainforest, southeastern Brazil and described their context of emission. We tested whether their parameters correlate with male body size, as well as temperature and stream geophony, all known to influence advertisement calls. Territorial calls were either simple or complex, composed of notes A (a short peep‐like sound) and B (a longer squeal‐like sound). Simple calls were predominant (86.8%); note A was present in 80.8% of the calls, while note B was present in 32.4% of them. Males emitted territorial calls mainly during daytime and in the presence of nearby males, in many instances accompanied by visual signals. Territorial calls were also emitted in the presence of a female. Body size correlated negatively with the duration of simple‐A calls, and temperature correlated negatively with the duration of complex calls. However, stream geophony did not influence parameters of territorial calls. Our results underscore that territorial calls are a crucial component of the species' behavioral repertoire, linked with environmental temperature but not stream noise, indicating different selective mechanisms compared with advertisement calls.Rubens Antonio Felipe Turin; Renato C. Nali

Context (archaeology); Territoriality; Adaptation (eye); Sexual selection; Noise (video); Geography; Ecology; Duration (music); Fish <Actinopterygii>

2026-06-23https://doi.org/10.1111/eth.70086Ethology 20261Search for dimuon resonance in the 35 to 75 GeV mass range using 140 fb−1 of 13 TeV pp collisions with the ATLAS detectorA bstract A model-independent search for low-mass resonances decaying into pairs of oppositely charged muons is presented. The analysis uses proton-proton collision data corresponding to an integrated luminosity of 140 fb − 1 , recorded by the ATLAS detector at the Large Hadron Collider between 2015 and 2018. The search targets hypothetical dimuon resonances in the invariant mass range from 35 GeV to 75 GeV. The modelling of this mass region is particularly challenging for conventional analytic background parameterisations. To address this, a Gaussian process regression technique is used to model the background. The dimuon mass spectrum is analysed for potential signals, and no statistically significant excess is observed. Upper limits at the 95% confidence level are set on the fiducial production cross-section of new resonances decaying promptly into muons, ranging from 20 fb to 110 fb, depending on the resonance mass. These results are further interpreted in the context of dark-photon and dark-matter-mediator models, leading to new constraints on their parameter spaces.G. Aad; Erlend Aakvaag; B. Abbott; Sara Abdelhameed; K. Abeling; Nils Julius Abicht; S. H. Abidi; Mohammed Aboelela; A. Aboulhorma; H. Abramowicz; B. S. Acharya; Anke Ackermann; C. Adam Bourdarios; L. Adamczyk; Sagar Addepalli; M. J. Addison; J. Adelman; A. Adıgüzel; T. Adye; A. A. Affolder; Y. Afik; M. N. Agaras; A. Aggarwal; C. Agheorghiesei; F. Ahmadov; S. Ahuja; S. Ahuja; X. Ai; G. Aielli; A. Aikot; M. Ait Tamlihat; B. Aitbenchikh; T. P. A. Åkesson; D. Akiyama; Nilima Nilesh Akolkar; S. Aktas; G. L. Alberghi; J. Albert; Una Helena Alberti; P. Albicocco; Guillaume Lucas Albouy; S. Alderweireldt; Z. L. Alegria; M. Aleksa; I. N. Aleksandrov; C. Alexa; T. Alexopoulos; F. Alfonsi; M. Algren; M. Alhroob; B. Ali; H. M. J. Ali; S. Ali; Samuel William Alibocus; M. Aliev; G. Alimonti; C. Allaire; B. M. M. Allbrooke; David R. Allen; Jonny Allen; Julia Frances Allen; C.S. Alley; A. Aloisio; F. Alonso; C. Alpigiani; Zainab Mohammad K Alsolami; A. Álvarez Fernández; Mario Alves Cardoso; M. G. Alviggi; M. Aly; Y. Amaral Coutinho; A. Ambler; C. Amelung; M. Amerl; Thiziri Amezza; Baktash Amini; Kyle Amirie; Artem Amirkhanov; S. P. Amor Dos Santos; Dimitra Amperiadou; S. An; C. Anastopoulos; T. Andeen; J. K. Anders; Adam Campbell Anderson; A. Andreazza; S. Angelidakis; A. Angerami; A. V. Anisenkov; A. Annovi; C. Antel; E. Antipov; M. Antonelli; F. Anulli; M. Aoki; T. Aoki; M. A. Aparo; L. Aperio Bella; M. Apicella; C. Appelt

Invariant mass; Resonance (particle physics); Atlas (anatomy); Atlas detector; Large Hadron Collider; Muon; Luminosity; Hadron; Context (archaeology); Physics; Particle physics; Nuclear physics; Compact Muon Solenoid; Detector; Range (aeronautics); Collider; Bhabha scattering; Electron–positron annihilation; Mass spectrum

2026-06-15https://doi.org/10.1007/jhep06(2026)165Journal of High Energy Physics 20261violencia_planilha_completo.txtCristian Kelly Costa Santos; Paulo Filipe Silva Siqueira; Waneska Alexandra Alves; Sibele Nascimento de Aquino

2026-01-01https://doi.org/10.48331/scielodata.ogynwg/lo6epbSciELO - Scientific Electronic Library Online Dataverse

20261Related diversification strategies and regional development traps in the Brazilian manufacturing industryAbstract This paper examines the potential and limitations of related diversification as a regional industrial development strategy in Brazil, drawing on the framework of evolutionary economic geography. Using the concept of regional development traps, we analyze the manufacturing sector across Brazilian microregions between 2012 and 2022, classifying them according to sectoral complexity and relatedness density. The results reveal a highly unequal productive structure, in which more complex and technologically intensive activities occupy central and strongly connected positions, while most regions remain concentrated in peripheral sectors with low connectivity. Microregions in the Southeast and South exhibit higher productive coherence and adaptive capacity, positioning them within self-reinforcing complexity loops. In contrast, most regions in the North, Northeast, and parts of the Central West remain locked in structural traps characterized by low complexity and weak sectoral relatedness. We also find strong temporal persistence and a prevalence of regressive transitions, indicating limited structural mobility and reinforcing long-standing patterns of uneven industrial development. These findings suggest that related diversification is strongly conditioned by initial regional structures and may intensify disparities if implemented through uniform industrial policies. Effective strategies, therefore, require place-based approaches focused on strengthening productive linkages and expanding local capabilities.Márcio Júlio Pereira Henriques; Igor Santos Tupy; Rafael F. de A. Campos

Diversification (marketing strategy); Regional development; Manufacturing; Manufacturing sector; Coherence (philosophical gambling strategy); Industrial production; Economic geography; Business; Economic system; Shift-share analysis; Industrial organization; Aerospace; Economics

2026-06-25https://doi.org/10.1007/s00168-026-01513-7The Annals of Regional Science 20261planilha_apos_a_remocao_ duplidades.txtCristian Kelly Costa Santos; Paulo Filipe Silva Siqueira; Waneska Alexandra Alves; Sibele Nascimento de Aquino

2026-01-01https://doi.org/10.48331/scielodata.ogynwg/2xlyo6SciELO - Scientific Electronic Library Online Dataverse

20261A Telemedicina e o Conhecimento Médico: A Teoria Precede a Prática ou a Prática Constrói a Teoria?Durante a pandemia de CO-VID-19, a necessidade de distanciamento social impulsionou o uso da telemedicina como ferramenta essencial para garantir o cuidado em saúde sem exposição ao vírus.Contudo, muitos médicos desconheciam suas bases teóricas e operacionais.Este estudo teve como objetivo analisar o nível de conhecimento dos médicos sobre as ferramentas da telemedicina, considerando o tempo de experiência profissional.Trata-se de um estudo observacional, descritivo e analítico, de abordagem quantitativa,Matheus dos Santos Macedo Soares; Cassiane Ferreira Pitombeira; Amanda de Almeida Jannuzzi Mendes; Anrafel Fernandes Pereira; Barbara da Silva Soares Telles; Marcos Alex Mendes da Silva; Rodolfo do Lago Sobral

Perspective (graphical); Interpretation (philosophy); Identity (music); Natural (archaeology); Context (archaeology); Philosophy; Epistemology

2026-06-08https://doi.org/10.22533/at.ed.820821026050615Revista Brasileira de Saúde 20261Discharge planning and guidance for preterm newborns: a best practice implementation projectINTRODUCTION: Prematurity, affecting approximately 10% of births, is a leading cause of neonatal morbidity and mortality. It is associated with neurological, respiratory, feeding, visual, and auditory problems; developmental delays; and chronic disease risks. The earlier the birth, the greater the risks. Lack of proper discharge planning can impair the health care team's assessment of a family's readiness, increasing morbidity. Although guidelines have been developed to support clinical discharge practices for preterm infants, gaps remain between evidence and practice. AIM: This project aimed to improve discharge planning and guidance for families or legal guardians of preterm newborns; assess compliance with evidence-based discharge criteria; standardize documentation; and unify discharge guidance provided to families of preterm infants admitted to the neonatal unit of a teaching hospital in São Paulo, Brazil. METHODS: A quasi-experimental before-and-after study was conducted using the JBI Evidence Implementation Framework, which combines clinical audits with a structured process to address barriers and enablers to evidence-based practice. The methodology includes identifying the practice area, engaging change agents, assessing context and readiness, baseline audits, implementing changes, follow-up audits, and evaluating sustainability. RESULTS: No statistically significant differences were found between the baseline and follow-up audits. Two criteria were already fully met. Four of the nine audited criteria showed improved compliance. Changes were supported by multimodal strategies, including an Institutional Care Guideline, an illustrated booklet with clear language for families, flowcharts to guide discharge planning, dissemination via AI-powered video and social media. CONCLUSIONS: The project enhanced discharge practices and guidance for families through multidisciplinary collaboration. Sustaining improvements will require ongoing attention. SPANISH ABSTRACT: http://links.lww.com/IJEBH/A645.Karina Faria de Souza; Denise Gomes Miyazato; Bárbara Barros Pereira Lobo; Silvia Maria Ibidi; Luiza Campos Carneiro; Patricia Tereza Cardoso de Camargo Severa; Ana Paula Almeida Brito; Kelli Borges dos Santos; Vilanice Alves de Araújo Püschel

Audit; Best practice; Context (archaeology); Discharge planning; Multidisciplinary approach; Health care; Baseline (sea); Compliance (psychology); Clinical Practice; Medicine; Medical emergency; Nursing; Quality management; MEDLINE; Process (computing); Evidence-based practice

2026-06-25https://doi.org/10.1097/xeb.0000000000000627International Journal of Evidence-Based Healthcare 20261ARQUÉTIPOS ANCESTRAIS DO DESTINOO artigo propõe uma análise simbólica dos dezesseis odus do merindilogun (jogo de búzios) como arquétipos do destino presentes em uma forma de clínica ancestral e ritual. Por meio de uma abordagem hermenêutica e interdisciplinar, propõe-se uma interpretação dos odus como mitologemas afro-diaspóricos que condensam temas como travessia, sacrifício, renascimento e ancestralidade. A análise dialoga, principalmente, com o Candomblé, a Psicologia Analítica desenvolvida por Carl Gustav Jung e os estudos de James Hillman, estabelecendo conexões entre espiritualidade afro-brasileira e Psicologia Simbólica. Ao enfatizar uma escuta decolonial dos saberes ancestrais, o estudo traz contribuições para o desenvolvimento de uma psicologia afrocentrada.Rodrigo Nogueira Martins

Perspective (graphical); Meaning (existential); Theme (computing); Order (exchange); Work (physics); Humanities; Philosophy; Sociology

2026-06-23https://doi.org/10.5752/p.1983-2478.2026v21n1e211d05Interações - cultura e comunidade 20261Corrigendum to: Is cardiac autonomic modulation influenced by beta blockers in adolescents with Duchenne Muscular Dystrophy?Talita Dias da Silva; Íbis Ariana Peña de Moraes; Luiz Carlos Marques Vanderlei; Carlos Bandeira de Mello Monteiro; Marcela Maria Carvalho da Silva; Fernando Pereira; Rodrigo Martins Dias; David Garner; Luís Fernando Grossklauss; Tatiana Dias de Carvalho; Celso Ferreira

BETA (programming language); Beta blocker; Autonomic nervous system; Adrenergic beta-Antagonists; Modulation (music); Medicine; Internal medicine; Cardiology

2026-06-25https://doi.org/10.1515/teb-2026-3009Translational Exercise Biomedicine 20261BIM PARA O CURSO DE GRADUAÇÃO EM ARQUITETURA: LIMITES, CONTRADIÇÕES E OPORTUNIDADESA difusão do Building Information Modeling (BIM) entre arquitetos e urbanistas exige transformações no ensino e na formação profissional. Um dos principais desafios refere-se à forma de inserção do BIM nos cursos de graduação, seja de modo transversal, integrado aos conteúdos específicos, seja por meio de disciplinas próprias voltadas às ferramentas e às discussões metodológicas. Independentemente da abordagem, o foco deve permanecer na formação de profissionais com competências amplas, coerentes com o perfil generalista do arquiteto e urbanista no Brasil, cuja atuação abrange planejamento, projeto, execução, assistência técnica, perícia e fiscalização. Nesse contexto, nem todas as atribuições dependem diretamente do domínio de ferramentas BIM, embora todas sejam impactadas pelas tecnologias digitais. Este artigo apresenta a proposta da disciplina “BIM na construção civil”, ofertada na UFRJ, e discute o potencial de replicabilidade em outras instituições, tomando como exemplo a UFJF. Busca-se capacitar o estudante a reconhecer os benefícios do BIM, escolher ferramentas adequadas e compreender oportunidades, dificuldades e impactos dessa adoção na organização das equipes de projeto e obra, considerando a adequação do conteúdo ao curso em que a disciplina se insere.Mônica Santos Salgado; L.H. Figueiredo; Aline Marques Calazans; Frederico Braida

Subject (documents); Work (physics); Philosophy; Humanities

2026-06-25https://doi.org/10.24840/978-972-752-358-0_005 20261Meta-analysis of woody plant diversity and aboveground biomass stock co-benefits across Amazon agroforestry systemsUnderstanding how biodiversity and aboveground biomass (AGB) interact in Amazonian agroforestry systems (AFS) is essential for designing land-use strategies that support climate mitigation and ecosystem resilience. We conducted a meta-analysis to quantify the co-benefits of woody species diversity and aboveground biomass stocks along a climatic gradient across Amazon agroforestry systems. We integrated updated field data from Amazonian AFS and applied a machine-learning clustering approach to identify a natural threshold in woody species richness, allowing us to objectively separate systems into simple (low-diversity) and complex (high-diversity) groups. Complex AFS exhibited higher aboveground biomass, with a median of 55.05 Mg ha−1, while simple AFS showed 36.21 Mg ha−1. Using generalized linear mixed models, we found that species richness and AGB are positively interdependent, indicating strong biodiversity–biomass co-benefits across AFS. Among climatic predictors, mean diurnal temperature range (MDR) emerged as the primary factor negatively influencing species richness, whereas other climatic variables, including mean annual temperature, potential evapotranspiration, and climatic water deficit, showed no significant effects. These results highlight that daily thermal variability, rather than broad-scale climatic gradients, plays a key role in shaping biodiversity within managed Amazonian landscapes. Although AFS can buffer some environmental stress through canopy structure and soil–vegetation interactions, high MDR remains a critical climatic constraint for biodiversity. Overall, our findings emphasize the intertwined roles of biotic and climatic drivers in Amazonian AFS and reinforce their potential to simultaneously conserve biodiversity and enhance carbon storage under increasing climate variability.Thamires Campos de Almeida; Sílvio Nolasco de Oliveira Neto; Arthur da Cruz Silva; Rodrigo Gomes Gorsani; Lorena Evangelista Fernandes; Sebastião Venâncio Martins; Mehdi Heydari; Andrés Iván Prato; Lisandra Mendes Louzada-Camilo; Ana Luiza Rangel; Jamerson Souza da Costa; Alisson Lopes Rodrigues; Pedro Manuel Villa

Biodiversity; Amazonian; Amazon rainforest; Ecosystem; Species richness; Biomass (ecology); Climate change; Canopy; Ecosystem services; Agroforestry; Environmental science; Ecology; Woody plant; Species diversity; Geography; Plant community; Carbon sequestration

2026-06-25https://doi.org/10.1007/s10457-026-01566-9Agroforestry Systems 20261BUILDING INFORMATION MODELING (BIM) NO ENSINO DE ARQUITETURA: ESTUDO DE CASO EM UNIVERSIDADES BRASILEIRASA integração de tecnologias digitais nos cursos de graduação em arquitetura enfrenta desafios. Embora a maioria dos profissionais reconheça a importância de processos como a Modelagem da Informação da Construção (Building Information Modeling - BIM), muitos docentes a consideram importante, mas não necessariamente fundamental para ser incorporado ao currículo. No Brasil, desde o estabelecimento da Estratégia BIM BR, os esforços para capacitar os profissionais aumentaram significativamente. Em 2021, a nova Lei de Licitações brasileira estabeleceu o BIM como preferencial nas licitações públicas. Diante desse cenário, algumas universidades criaram o que se convencionou chamar de “Células BIM”, reunindo docentes, discentes e pesquisadores interessados em incorporar o BIM no ensino. Este artigo apresenta uma análise do desempenho de duas Células BIM instaladas em diferentes universidades federais brasileiras. Foi realizado um levantamento com docentes dos cursos de graduação em Arquitetura e Urbanismo para identificar opiniões e interesse em relação ao BIM. Os resultados revelam visões divergentes e convergências. No entanto, o principal problema apontado pelos docentes refere-se à falta de tempo para se dedicar ao aprofundamento do conhecimento no tema. Esta constatação indica a necessidade de mudanças na forma de atuação das Células para que o BIM seja reconhecido como parte fundamental da formação em Arquitetura e Urbanismo e não como um processo independente.Frederico Braida; Mônica Santos Salgado

Process (computing); Standardization; Principal (computer security); Engineering; Computer science; Humanities

2026-06-25https://doi.org/10.24840/978-972-752-358-0_007 20261DIREITOS HUMANOS E POVOS RIBEIRINHOS NA PAN-AMAZÔNICA: INVISIBILIZAÇÃO INSTITUCIONAL, JUSTIÇA AMBIENTAL E DESAFIOS À SUSTENTABILIDADEEsse artigo se propõe a analisar os desafios enfrentados pelos povos ribeirinhos da Pan-Amazônia no que se refere ao reconhecimento institucional, à proteção de seus modos de vida e à efetivação da justiça ambiental, à luz do marco normativo dos direitos humanos. Trata-se de pesquisa qualitativa, de caráter exploratório e analítico, baseada em revisão bibliográfica e documental. Foram utilizados dados secundários provenientes de instituições oficiais e relatórios internacionais, além de tratados internacionais. Verificou-se que os povos ribeirinhos permanecem em condição de invisibilidade institucional, com reconhecimento jurídico insuficiente e baixa efetividade das políticas públicas existentes. Identificaram-se impactos significativos decorrentes de grandes empreendimentos econômicos, como deslocamentos forçados, insegurança alimentar, degradação ambiental e restrições ao acesso a direitos fundamentais, como saúde e educação. Observou-se, ainda, a ocorrência de violações sistemáticas de direitos humanos e riscos à integridade de lideranças comunitárias. Conclui-se que a efetivação dos direitos dos povos ribeirinhos exige a superação de uma lógica de desenvolvimento baseada em paradigmas extrativistas e coloniais. É imprescindível o fortalecimento de políticas públicas específicas, o reconhecimento pleno dessas comunidades como sujeitos de direitos e a incorporação de abordagens baseadas na justiça ambiental, no pluralismo jurídico e na sustentabilidade socioambiental.Patricia Miranda Pereira; Bianca Landau Braile; Pedro Ribeiro de Oliveira Sousa; Celso Martins Santos; A de Lima Silva; Ana Cláudia Santana; Felipe Lucas Soares; Benvinda Fernandes de Macedo Martins; Luiza Cattoni Carvalho Pinto

Human rights; Order (exchange); Government (linguistics); Field (mathematics); Latin Americans; Political science

2026-01-01https://doi.org/10.37885/260421672Editora Científica Digital eBooks 20261P208 Efficacy of mogamulizumab in cutaneous T-cell lymphoma: a systematic review and meta-analysisAbstract Cutaneous T-cell lymphomas (CTCLs) are heterogeneous skin malignancies. Mycosis fungoides (MF) and Sézary syndrome (SS) are the most prevalent. Most systemic treatments produce suboptimal responses. Mogamulizumab, an anti-CCR4 monoclonal antibody, demonstrated a superior overall response rate (ORR) compared with vorinostat in the MAVORIC phase III trial, leading to regulatory approval for relapsed or refractory MF and SS. However, its real-world efficacy remains poorly characterized. Currently, no systematic review has integrated the trial evidence with real-world data to estimate efficacy across clinical settings. The aim of this study was to synthesize clinical trial and observational data on the efficacy of mogamulizumab in CTCLs. We systematically searched PubMed, Embase and Cochrane CENTRAL (8 December 2025) for clinical trials and cohort studies reporting mogamulizumab monotherapy in CTCL. Primary outcomes were the CTCL ORR and subtype-specific ORRs in MF and SS. Single-arm proportions were pooled using a random effects meta-analysis of logit-transformed rates. Heterogeneity was assessed using the I2-statistic. The review was registered with PROSPERO (CRD420251171992). Of 1167 records, 6 studies were included (1 RCT, 2 single-arm interventional studies and 3 observational cohorts). These comprised 425 patients with CTCL with a median of three prior systemic therapies. The pooled ORR for CTCL was 40.4% [95% confidence interval (CI) 27.7–53.1; I2 = 86%). Subgroup analysis demonstrated a higher efficacy in SS (ORR 52.5%, 95% CI 34.8–70.3; I2 = 81.9%) than in MF (ORR 31.1%, 95% CI 20.7–42.1; I2 = 59.7%). Heterogeneity was partially attributable to disease stage, prior treatments and trial vs. real-world practices. Mogamulizumab demonstrates clinically meaningful efficacy in CTCL, with greater ORR in SS than MF, supporting its preferential use in patients with blood involvement. In SS, this pooled ORR compares favourably to the 2% ORR reported for vorinostat in the MAVORIC trial. These findings provide evidence-based guidance for the position of mogamulizumab within CTCL management. This is particularly relevant for SS, characterized by immune dysregulation, where substantial clinical efficacy is necessary to justify systemic immune modulation.Ayomide Lawal; Kélen Klein Heffel; Maria Antonia; Advait Raja; Ana Paula Pedroso Junges; Amanda Ribeiro Rangel

Mycosis fungoides; Clinical trial; Observational study; Confidence interval; Refractory (planetary science); Cohort; Meta-analysis; Cohort study; Medicine; Internal medicine; Dermatology; Adverse effect; Hazard ratio; Randomized controlled trial; Oncology

2026-06-01https://doi.org/10.1093/bjd/ljag086.235British Journal of Dermatology 20261An integrative analysis of global patterns of CH 4 ebullition in inland watersCH 4 ebullition is one of the least well-constrained components of ecosystem CH 4 budgets in inland waters, despite its clear dominance in many habitats. Studies have shown that CH 4 ebullition varies greatly in space, both within and among ecosystems, and in time, being extremely episodic, and this variability poses significant challenges for quantifying and modelling the process. Global syntheses of CH 4 or greenhouse gases have not explicitly focused on CH 4 ebullition, and the literature on the topic is still highly fragmented. Although there is evidence of links between ebullition and environmental factors, particularly at local scales, there is still considerable uncertainty on the magnitude and regulation of ebullition at regional and global scales. Here, we present an integrative analysis of CH 4 ebullition in inland waters based on a systematic literature search, where we have combined a qualitative review of CH 4 ebullition studies, a meta-analysis of effect sizes between environmental factors and ebullition in freshwater ecosystems, and a quantitative data analysis of global ebullition fluxes, bubble-related variables, and associated environmental factors to gain a broader understanding of CH 4 ebullition and its global regulation. We show that despite the intrinsic variability in CH 4 ebullition, this emission pathway has clear global patterns across climatic and environmental gradients. Our meta-analysis reveals that waterbody morphometry, carbon source availability, and climate-driven variables are key drivers of CH 4 ebullition, but their effect varies. For example, the positive effect of temperature on CH 4 ebullition varied across climatic zones and ecosystem types. The quantitative analysis of the database we assembled complemented these results by showing that global CH 4 ebullition fluxes are higher in shallow ponds, eutrophic systems, and habitats in tropical and subtropical regions. This database also yielded global-scale empirical models, demonstrating that, in addition to climate and carbon sources, system productivity and trophic status also play key roles in the global regulation of CH 4 ebullition in inland waters. Our results further revealed that bubble CH 4 concentrations and isotopic signatures associated with CH 4 ebullition fluxes provide essential insights into sediment CH 4 dynamics.Mariana Peifer Bezerra; Pedro Maia Barbosa; Paul del Giorgio

Greenhouse gas; Dominance (genetics); Ecosystem; Global warming; Climate change; Global change; Global temperature; Environmental science; Ecology; Atmospheric sciences; Carbon cycle; Methane; Physical geography; Freshwater ecosystem; Greenhouse effect; Trend analysis

2026-01-01https://doi.org/10.1139/er-2026-0041Environmental Reviews 20261Early catheter ablation vs. antiarrhythmic drugs in treatment-naïve ischaemic ventricular tachyarrhythmias: a meta-analysis of randomized controlled trialsINTRODUCTION: Antiarrhythmic drugs (AADs) have traditionally been used as first-line therapy for ventricular tachycardia (VT) but are frequently associated with systemic toxicities and drug interactions. Therefore, we performed a meta-analysis comparing early catheter ablation (CA) with AAD therapy as initial treatment for VT in patients with prior myocardial infarction. METHODS AND RESULTS: PubMed, Embase, and the Cochrane Library were searched for randomized controlled trials comparing CA vs. AAD in patients naïve to both strategies. Meta-analysis was performed using Review Manager. Three randomized trials including 618 patients were analysed. No significant differences were observed in all-cause mortality, appropriate implantable cardioverter-defibrillator (ICD) therapies (including shocks and antitachycardia pacing), ventricular arrhythmia storm, hospitalizations, or adverse events between strategies. Leave-one-out sensitivity analysis identified one trial as the primary contributor to between-study heterogeneity. CONCLUSION: Early catheter ablation provides similar efficacy to first-line antiarrhythmic drug therapy for major arrhythmic and survival outcomes, with reductions in hospitalizations and treatment-related adverse events, although largely driven by one trial. These findings support consideration of CA as a first-line therapeutic strategy in selected patients with ischaemic VT.Tiago Moura Façanha; Anna Isabelle Gomes Pereira; Maria Fernanda Carvalho Garcia; Enzo Tunala Mendonça; João Vitor Jacobsen Ramos; Leonardo Antunes Mesquita

Randomized controlled trial; Ventricular tachycardia; Adverse effect; Catheter ablation; Drug; Tachycardia; Anti-Arrhythmia Agents; Clinical trial; Medicine; Internal medicine; Cardiology; Anesthesia; Pharmacotherapy; Ablation; Proarrhythmia; Catheter; Cochrane Library

2026-04-25https://doi.org/10.1093/europace/euag073EP Europace 20261Masculinidades homossexuais na narrativa de Shane Hollander em Heated RivalryEste trabalho analisa a trajetória do personagem Shane Hollander, da série Heated Rivalry, para discutir o autorreconhecimento e a constituição do sujeito homossexual. Compreende-se a obra como um currículo-artefato que agencia modos de subjetivação e possibilita pensar as masculinidades homossexuais a partir de sua trajetória. A fundamentação teórico-metodológica ancora-se nos estudos pós-estruturalistas de inspiração foucaultiana. A análise demonstra que Shane percorre um processo de “desprendimento de si” ao tensionar os percursos normativos que moldaram sua forma de existir. Conclui-se que a narrativa da série atua como um espaço (trans)formador que, ao expor as dores e os tensionamentos do reconhecimento, reverbera múltiplas vivências e permite vislumbrar novas possibilidades de existência para homens gays.John Jamerson da Silva Brito; Roney Polato de Castro

Identity (music); Subject (documents); Action (physics); Process (computing); Perspective (graphical); Sociology; Art; Humanities

2026-06-17https://doi.org/10.18391/riecedu.v1i.5300Revista da RIECEdu 20261Three-Dimensional Evaluation of Accessory Canals in Primary Maxillary Molars Using Micro-CTThe objective of the present study was to characterize the internal anatomy of primary maxillary molars by evaluating the presence and distribution of accessory canals using micro-computed tomography (micro-CT). Seventeen primary maxillary molars from donors aged 2 to 8 years were scanned using micro-CT and reconstructed using NRecon software. Only teeth with at least two-thirds of the root structure preserved were included. Image analysis was performed with ImageJ, supplemented by CTan and CTvol software. Accessory canals were identified and counted at each root and categorized by root third. Statistical analyses, including Kruskal-Wallis and Mann-Whitney tests, were applied (p<0.05). A total of 47 roots were analyzed, with 68.08% exhibiting at least one accessory canal, totaling 96 canals. The apical third showed a higher number of accessory canals compared to cervical (p=0.01), with a mean of 0.87±1.05, accounting for 42.71% of all accessory canals identified. The middle third had a mean of 0.80±1.42, representing 39.58% of the total, while the cervical third exhibited the lowest mean (0.36±0.84), corresponding to 17.71% of the overall canals. Notably, 57.44% of the apical thirds had at least one accessory canal. Also, considering the presence of at least one accessory canal, the apical third also presented a higher prevalence (p<0.01). Accessory canals are highly prevalent in the apical third, highlighting the complexity of their internal anatomy and the importance of thorough endodontic management.Alice Moura Martins; Juliana de Medeiros Matos; Carolina Oliveira de Lima; Ana Flávia Almeida Barbosa; Emmanuel João Nogueira Leal Silva; Tatiana Kelly da Silva Fidalgo

Molar; Statistical analysis; Mandibular third molar; Mandibular second molar; Medicine; Dentistry; Orthodontics; Anatomy

2026-01-01https://doi.org/10.1590/0103-644020256744Brazilian Dental Journal 20261Efficacy and Safety of Perampanel in Patients With Brain Tumor-Related EpilepsyPURPOSE OF REVIEW: Epileptic seizures are a common and often debilitating complication in patients with brain tumors, significantly affecting quality of life and clinical outcomes. Brain tumor-related epilepsy (BTRE) is characterized by complex pathophysiologic mechanisms, notably glutamate-mediated neuronal hyperexcitability within the peritumoral environment. Perampanel, a selective, noncompetitive antagonist of the AMPA glutamate receptor, represents a mechanistically targeted antiseizure medication that may be particularly suited to this context. This review aims to systematically evaluate and synthesize the available evidence regarding the efficacy and safety of perampanel in patients with BTRE, focusing on seizure control, oncologic outcomes, and tolerability in real-world clinical settings. RECENT FINDINGS: A systematic search of PubMed, Embase, and Cochrane Library identified 8 observational studies involving a total of 382 patients with brain tumors and associated seizures treated with perampanel. Across studies, 57.0% of patients were male, and the mean participant age ranged from 43 to 58 years. Pooled analyses demonstrated that 42% (95% CI 27%-59%) of patients achieved seizure freedom, while 46% (95% CI 31%-61%) experienced a ≥50% reduction in seizure frequency. Oncological progression was reported in 39% (95% CI 17%-65%) of patients, with no evidence of perampanel effect on tumor behavior. Adverse events occurred in 26% (95% CI 17%-38%) of patients, most of which were mild to moderate and consistent with the known safety profile of perampanel. SUMMARY: Perampanel is associated with meaningful seizure control in a substantial proportion of patients with brain tumor-related epilepsy, including high rates of seizure freedom and significant seizure reduction. Importantly, its use does not appear to influence oncologic progression nor substantially increase the incidence of adverse events. Although limited by the nonrandomized nature of the available studies, these findings support perampanel as a valuable therapeutic option for symptomatic seizure management in BTRE, with potential utility in both adjunctive treatment strategies and palliative care settings. Further prospective and controlled studies are warranted to better define its optimal role and long-term impact in this complex patient population.Anderson M.P. Da Silva; Ocílio Ribeiro Gonçalves; Gabriel Caruso Novaes Tudella; Giovana Menegucci; Augusto Utida Klostermann; Maria E Scheffer Valverde; Patrick F. Meldola; Ahmet Günkan; Gustavo Sousa Noleto

Perampanel; Epilepsy; Antiepileptic drug; Disease; Adverse effect; Medicine; Intensive care medicine; Pediatrics; Internal medicine

2026-06-26https://doi.org/10.1212/cpj.0000000000200636Neurology Clinical Practice 20261Artefatos culturais e processos de constituição de jovens trans*Ao serem interpelados pelos artefatos culturais, estabelecendo com eles distintas relações – aceitação, recusa, negociação – os indivíduos passam a entender, sentir, experienciar o mundo de formas particulares. Além disso, passam a entender a si mesmos como sujeitos de certo tipo (quanto ao gênero, quanto à sexualidade, quanto à raça e etnia, etc.). A presente pesquisa foi construída sob inspiração de perspectivas pós-estruturalistas e foucaultianas, tendo como estratégia metodológica a entrevista narrativa. Foram entrevistadas/os cinco jovens, na faixa etária de 12 a 18 anos, sendo 3 garotas e 2 garotos trans*. Durante a entrevista, foi abordado se havia algum tipo de produto cultural (filmes, séries, músicas/artista, programas de TV, novelas, propagandas, livros, sites, perfis no YouTube, redes sociais etc.) que possa ter marcado o processo de constituição delas/es enquanto pessoa trans*. Foram citados diversos tipos de artefatos culturais, tais como séries, novelas, animações, canais do YouTube, músicas. Destacamos o papel constitutivo como uma função pedagógica no sentido de que os sujeitos estabelecem com os artefatos culturais relações de significação que tem implicações em suas formas de pensar, sentir, agir e viver. Nesta pesquisa, jovens trans nos deram pistas desses processos relacionais, de modo que pudemos argumentar da relevância dos artefatos culturais para a constituição de subjetividades trans em processos de transição e afirmação de gênero.Maria Angélica Vargas Pinto De Faria; Roney Polato de Castro

Solid earth; Intellectual ability; Cultural environment; Humanities; Philosophy

2026-06-17https://doi.org/10.18391/riecedu.v1i.5284Revista da RIECEdu 20261Embodied Interoception Questionnaire (Intero‐10): Development, Validation, and Application in People With Neuropathic Chronic PainBACKGROUND: Embodied interoception refers to the perception of the body's state and is a multidimensional cognitive process. Pain experience feeds interoceptive networks with information from the state of the body and the subjective experience of pain would be influenced by an individual's trait embodied interoceptive profile. METHODS: Here we developed and validated the Intero-10, a questionnaire designed to evaluate embodied interoception based on trait interoceptive channels in healthy adults (n = 381) and latter assessed how it relates to neuropathic pain features (n = 86) as a pilot exploratory assessment. The relationship between trait and state interoceptive responses was examined during experimentally evoked interoceptive psychophysicsal tasks, specific to each interoceptive channel. RESULTS: Trait and state interoceptive scores were correlated only for affective-emotional components (unpleasantness, p < 0.05), but not for intensity ratings, suggesting that the negative valence of momentary lived experience is more stable over time than intensity estimations. The Intero-10 final version included both embodied interoceptive perception intensity (heartbeat, heat, itching, dyspnea, sleep, muscle fatigue and anguish) and unpleasantness (heartbeat, dyspnea and nausea) domains. Intero-10 demonstrated adequate content validity, good internal consistency (Cronbach's α = 0.81), good reliability (> 0.75) and a single-factor structure. Patients with neuropathic pain completed the Intero-10 alongside standard pain, mood, sleep and quality of life assessments. Embodied interoception scores correlated with mood and quality of life and partially mediated the correlation between pain interference and quality of life (β = -0.0093). CONCLUSION: Specific assessment of embodied interoceptive channels may broaden our current assessment of people with chronic pain and of those at risk to develop it. SIGNIFICANCE STATEMENT: This study introduces the Embodied Interoception Questionnaire (Intero-10), a novel tool to assess how individuals perceive bodily states across distinct interoceptive channels. By capturing both sensory and affective dimensions of interoception, the instrument provides a structured approach to investigate trait-state relationships. Its application in neuropathic chronic pain offers preliminary evidence that embodied interoceptive experience can be systematically quantified, opening new avenues for understanding individual variability and for developing targeted interventions in pain management.Ana Mércia Fernandes; V Cardoso De Oliveira Júnior; Carolina C. dos Santos; Samantha K. Millard; Jorge A. M. P. Júnior; Marcell M. Barbosa; Pedro N. Martins; Suzana C. Nogueira; Maercio M. Alves; Pedro H. M. da Cunha; Danielle C. Fonseca; Luccas S. Laferreira; Paulo R. Santos‐Silva; Nayara S. Carvalho; Vinícius C. Iamonti; C Carvalho; Camila S. Dale; Gabriel T. Kubota; Lin T. Yeng; Manoel J. Teixeira; Abrahão F. Baptista; Interoception Study Group; Daniel Ciampi de Andrade

Interoception; Embodied cognition; Cognition; Mood; Quality of life (healthcare); Perception; Neuropathic pain; Chronic pain; Trait; Psychology; Sensation; Physical medicine and rehabilitation; Anxiety; Clinical psychology; Psychometrics; Pain catastrophizing; Cognitive psychology; Physical therapy; Sensory system; Somatosensory system; Audiology

2026-06-26https://doi.org/10.1002/ejp.70320European Journal of Pain 20261ApresentaçãoEste texto apresenta o dossiê inaugural da Revista da RIECEdu, intitulado "Pesquisas com Estudos Culturais em Educação: Artefatos e Pedagogias sob Investigação". A coletânea nasce do encontro entre a Rede Internacional de Estudos Culturais em Educação (RIECEdu) e o V Encontro Sobre Gênero, Educação e Sexualidades (EMGES), reunindo artigos que foram criteriosamente selecionados a partir das apresentações ocorridas na Universidade Federal do Maranhão (UFMA). Sob uma fundamentação teórica pautada nos Estudos Culturais em Educação (ECE) e em perspectivas pós-estruturalistas , a coletânea desafia as fronteiras da escolarização formal ao examinar diversos artefatos cotidianos e midiáticos, tais como canções de brega funk, campanhas de saúde pública, fotografias históricas, redes sociais (Facebook, TikTok), literatura e exposições artísticas, compreendendo-os como pedagogias e/ou currículos culturais. Por meio dessas análises, as pesquisas investigam processos de subjetivação e a produção de identidades, abarcando eixos temáticos como gênero, sexualidade, masculinidades, infância, deficiência e diversidade. Assim, os estudos evidenciam tanto os mecanismos de regulação e reprodução de desigualdades operados pelas normas sociais, quanto a emergência de brechas para a negociação, a agência e a resistência democrática em prol da justiça social.Danilo Araujo de Oliveira; Alcidesio Oliveira da Silva; Roney Polato de Castro; Sirlene Mota Pinheiro da Silva

Period (music); Index (typography); Humanities; Art

2026-06-17https://doi.org/10.18391/riecedu.v1i.5330Revista da RIECEdu 20261A new species of Salpingogaster Schiner, 1868 (Diptera: Syrphidae) from Brazil, a potential control agent of spittlebugs (Hemiptera: Cercopidae)ABSTRACT A new species of Salpingogaster is described from southern Brazil, S. distincta Mengual, Veríssimo & Auad sp. nov. The new species is very similar to the widespread S. nigra Schiner. We describe the new species in full and provide images and DNA barcodes of the closest species to differentiate them. Moreover, a RAPD analysis was performed to test its value to distinguish our new species from Salpingogaster nigra. Larvae and adults of the new species were collected in fields of elephant grass, Cenchrus purpureus (Schumach.) Morrone. Larvae of the new species are reported feeding on spittlebugs Mahanarva spectabilis and Aeneolamia contigua (Hemiptera: Cercopidae). Until now our efforts to rear the species in captivity have not been successful.Ximo Mengual; Bruno Antônio Veríssimo; Milena Duarte; Rafaella Lima Oliveira de Magalhães; Ana Luisa Sousa Azevedo; Alexander Machado Auad

Larva; Captivity; RAPD; Clade; Species complex; Biology; Zoology; Ecology

2026-01-01https://doi.org/10.1590/1806-9665-rbent-2026-0027Revista Brasileira de Entomologia 20261TECNOLOGIAS DIGITAIS NA ODONTOLOGIA: APLICAÇÕES DO FLUXO DIGITAL NA REABILITAÇÃO ORAL CONTEMPORÂNEAA incorporação de tecnologias digitais tem promovido transformações significativas nos processos clínicos e laboratoriais da odontologia contemporânea, especialmente no campo da reabilitação oral. O fluxo digital, fundamentado na integração entre escaneamento intraoral, fotografias digitais, tomografia computadorizada de feixe cônico, softwares de planejamento virtual, sistemas CAD/CAM, manufatura subtrativa, manufatura aditiva, desenho digital do sorriso e inteligência artificial, tem ampliado as possibilidades diagnósticas e terapêuticas, proporcionando maior previsibilidade, precisão e eficiência nos tratamentos reabilitadores. Este artigo tem como objetivo analisar as principais aplicações dessas tecnologias na prática odontológica atual, discutindo seus impactos sobre a qualidade dos procedimentos restauradores, a comunicação entre profissionais e pacientes, a integração entre clínica e laboratório e a otimização do tempo clínico. Trata-se de uma pesquisa de abordagem qualitativa, exploratória e bibliográfica, fundamentada em revisão da literatura científica sobre odontologia digital, reabilitação oral, prótese dentária, implantodontia, escaneamento intraoral, CAD/CAM, impressão 3D e planejamento virtual. Os resultados indicam que o fluxo digital representa uma mudança paradigmática na reabilitação oral, ao permitir maior padronização de etapas, redução de distorções associadas a procedimentos convencionais, armazenamento de dados digitais, melhor comunicação interdisciplinar e personalização dos tratamentos. Entretanto, persistem desafios relacionados aos custos de implementação, à curva de aprendizagem, à atualização tecnológica contínua, à interoperabilidade entre sistemas, à proteção de dados, à validação clínica de materiais e à necessidade de formação profissional. Conclui-se que a transformação digital tem consolidado novas perspectivas para a prática clínica odontológica, fortalecendo a integração entre inovação tecnológica, odontologia baseada em evidências e excelência assistencial.Roberto Xavier Motta; Aimée Maria Guiotti; Werônica Jaernevay Silveira Mitterhofer; Francilena Maria Campos Santos Dias; Alice Carvalho Silva; Juliana Carolina da Silva Soares; Tatiana Elenice Cordeiro Soares

Work flow; Data collection; Digital health; Work (physics); Computer science; Physics; Humanities

2026-06-26https://doi.org/10.70773/revistatopicos/782439238Revista Tópicos. 20261Optimizing the drying process for lemongrass and Basil: A trade-off between drying efficiency and essential oil qualityABSTRACT Aromatic herbs produce essential oils comprising volatile and lipophilic compounds derived from secondary metabolism. These plants must be dried immediately after harvesting under controlled conditions to preserve their chemical profile. Herein, we investigated the drying behavior of lemongrass (Cymbopogon citratus) and white basil (Ocimum basilicum L.) leaves and evaluated the effect of drying air temperature (40 °C, 50 °C, and 60 °C) on the yield and composition of essential oil. The experiments were conducted in a completely randomized design with a 2 × 3 factorial arrangement. Hydrodistillation using a Clevenger apparatus was employed to extract essential oils. The drying data were fitted to nonlinear mathematical models. Increasing temperature decreased drying time and increased drying rate. The Page model was the most suitable for describing the drying kinetics of lemongrass, whereas the Modified Page model was the most suitable for basil. The drying temperature significantly affected essential oil yield, with 40 °C providing the highest yields (2.259% for lemongrass and 2.64% for basil). In basil, 1,8-cineole (14.14%-32.52%) and linalool (27.32%-46.08%) were the major compounds identified, whereas in lemongrass, geranial (51.59%-55.38%) was identified. Temperature also changed oil composition, affecting the relative abundance of key compounds. Overall, the study results indicate a practical trade-off: lower temperatures preserve essential oil yield and chemical integrity; in contrast, higher temperatures enhance drying efficiency at the expense of compositional stability. Our findings will help guide temperature selection based on whether the industrial objective prioritizes drying performance or essential oil quality.Paula Giarolla Silveira; Jeane Eduarda Silveira; Jefferson Luiz Gomes Corrêa; Rafael Peron Castro; Pedro Castro Neto; Irineu Petri Júnior

Essential oil; Linalool; Basilicum; Factorial experiment; Yield (engineering); Process (computing); Response surface methodology; Pulp and paper industry; Chemistry; Food science; Chemical composition; Ocimum; Air temperature; Horticulture; Mathematics; Process engineering

2026-01-01https://doi.org/10.1590/1413-7054202650017125Ciência e Agrotecnologia 20261Avaliação em larga escala de produção de texto na educação básicaOne of the main challenges for Portuguese language teachers in basic education is grading students' written work, a task that demands time, knowledge of the genre, and prior actions such as creating clear instructions and building a consistent grading framework. Nonetheless, large-scale external writing assessments have been applied in basic education, revealing inconsistencies tied to the above-mentioned challenges. This article discusses the evaluation of writing in a school environment and analyzes the adequacy of the instruments used, based on exams and grading frameworks from the Programa Escola das Adolescências (Adolescent Schools Program), a federal government initiative. The analysis considers the relevance of the selected genres and the coherence of the assessment proposal and parameters. The results indicate alignment between the genres and curriculum guidelines, but also weaknesses in the proposal and evaluation criteria, which compromise an accurate diagnosis of students' writing abilities.Natália Sathler Sigiliano; Cláudia Aparecida Ferreira Ferraz; Janice Valentino Magalhães Lana; Roberta Baffa Andrade

Grading (engineering); Portuguese; Curriculum; Compromise; Strengths and weaknesses; Coherence (philosophical gambling strategy); Relevance (law); Computer science; Pedagogy; Government (linguistics)

2026-03-29https://doi.org/10.26512/les.v26i2.59863Cadernos de Linguagem e Sociedade 20261EXTENDED SDT Consolidated formalism, physical implications, and roadmap to closureExecutive summary · Earlier SDT already establishes a coherent EFT chain: thermodynamic substrate -> Newtonian response -> galactic AQUAL bridge -> relativistic composite physical metric -> one-loop radiative audit. · The physical metric is composite and receives universal coupling from matter and from the infrared tensor sector. The densification-first reading identifies the substrate perturbation with the Newtonian potential, avoiding double counting through a matching prescription. · In the galactic sector, the AQUAL function fixes the form of the RAR and BTFR within the adopted kinetic completion. The absolute scale remains condensed into a calibrated universal constant, τ, which has not yet been derived from microphysics. · The new temporal branch R7.2g derives a rigid FLRW background a ∝ t^(1/3), reduces the scalar sector to a single variable σ, and obtains a healthy quadratic action on the regular branch. · The new Dirac-Bergmann programme R7.2h constructs an auxiliary parent action equivalent to the original temporal branch and finds 41 configuration variables, 7 nondegenerate velocities, and 34 primary constraints. The first primary-preservation stage has now been completed in a numerical audit of the regular temporal branch. · On three regular, nontrivial temporal backgrounds, the 34 secondary constraints are locally independent in the tested Fourier sector. The ultralocal primary-secondary block has numerical rank 30, leaving four unresolved consistency channels; this is not yet a first-/second-class split or a gauge count. · The projected secondary-secondary bracket on those four channels has one numerically stable antisymmetric second-class pair. A preliminary compatibility-vector construction is not yet a complete linearized Dirac consistency operator and cannot be used to count tertiary constraints. · The immediate task is R7.2h-3b-2: construct the full linearized Fourier consistency operator, determine the rank of its compatibility symbols, and only then build local tertiary constraints and continue the Dirac chain.Paulo Giovanni de Albuquerque Suassuna

Operator (biology); Gauge fixing; Discretization; Scalar (mathematics); Antisymmetric relation; Hypersurface; Quadratic equation; Mathematics; Mathematical analysis; Metric (unit); Theoretical physics; Physics; Classical mechanics; General relativity; Covariant transformation

2026-06-26https://doi.org/10.5281/zenodo.20938289Zenodo (CERN European Organization for Nuclear Research) 20261Escolhas alimentares de tabagistas que iniciam tratamento para cessação tabágica em um modelo por telemedicinaO tabagismo é responsável por mais de 8 milhões de mortes anuais em todo o mundo. No Brasil, após décadas de redução consistente, a prevalência de fumantes adultos foi de 9,3% em 2023, com indícios recentes de estabilização e discreto aumento em alguns grupos populacionais. O objetivo deste estudo foi avaliar os fatores que influenciam as escolhas alimentares de tabagistas e analisar a adesão ao tratamento para cessação tabágica realizado por telemedicina. Foi realizada uma pesquisa com 90 fumantes portadores de múltiplas doenças crônicas, recrutados em ambulatórios e Unidades de Atenção Primária à Saúde. Foram incluídos indivíduos com idade superior a 18 anos, portadores de pelo menos duas doenças crônicas e em acompanhamento médico. Coletaram-se informações sociodemográficas, antropométricas, nível de atividade física, histórico tabágico, dependência nicotínica, craving e escolhas alimentares. A maioria dos participantes era do sexo feminino (67,8%), idosa (55,6%), branca (56,5%), casada (40,5%) e apresentava escolaridade inferior a oito anos de estudo (49,9%). Embora tenha predominado a eutrofia pelo índice de massa corporal, 69% apresentaram circunferência abdominal aumentada. As escolhas alimentares foram influenciadas principalmente pelo apelo sensorial e pelo controle de peso. Observou-se associação entre alta dependência nicotínica e maior consumo de cigarros, bem como boa adesão inicial ao modelo de telemedicina, com redução da participação ao longo do acompanhamento. Os resultados sugerem que aspectos relacionados ao comportamento alimentar devem ser considerados nas estratégias de cessação tabágica, especialmente em programas realizados por telemedicina.Marcela Oliveira Rabelo; Arise Garcia de Siqueira Galil; Nathércia Percegoni; Aline Silva de Aguiar

Behavioral therapy; Behavioral analysis; Affect (linguistics); Psychology; Humanities; Medicine

2026-06-23https://doi.org/10.33448/rsd-v15i6.51310Research Society and Development 20261EXTENDED SDT Consolidated formalism, physical implications, and roadmap to closureExecutive summary · Earlier SDT already establishes a coherent EFT chain: thermodynamic substrate -> Newtonian response -> galactic AQUAL bridge -> relativistic composite physical metric -> one-loop radiative audit. · The physical metric is composite and receives universal coupling from matter and from the infrared tensor sector. The densification-first reading identifies the substrate perturbation with the Newtonian potential, avoiding double counting through a matching prescription. · In the galactic sector, the AQUAL function fixes the form of the RAR and BTFR within the adopted kinetic completion. The absolute scale remains condensed into a calibrated universal constant, τ, which has not yet been derived from microphysics. · The new temporal branch R7.2g derives a rigid FLRW background a ∝ t^(1/3), reduces the scalar sector to a single variable σ, and obtains a healthy quadratic action on the regular branch. · The new Dirac-Bergmann programme R7.2h constructs an auxiliary parent action equivalent to the original temporal branch and finds 41 configuration variables, 7 nondegenerate velocities, and 34 primary constraints. The first primary-preservation stage has now been completed in a numerical audit of the regular temporal branch. · On three regular, nontrivial temporal backgrounds, the 34 secondary constraints are locally independent in the tested Fourier sector. The ultralocal primary-secondary block has numerical rank 30, leaving four unresolved consistency channels; this is not yet a first-/second-class split or a gauge count. · The projected secondary-secondary bracket on those four channels has one numerically stable antisymmetric second-class pair. A preliminary compatibility-vector construction is not yet a complete linearized Dirac consistency operator and cannot be used to count tertiary constraints. · The immediate task is R7.2h-3b-2: construct the full linearized Fourier consistency operator, determine the rank of its compatibility symbols, and only then build local tertiary constraints and continue the Dirac chain.Paulo Giovanni de Albuquerque Suassuna

2026-06-26https://doi.org/10.5281/zenodo.20938290Zenodo (CERN European Organization for Nuclear Research) 20261DAISY BRÉSCIA E O ENSINO DE LEITURA NO BRASIL NA SEGUNDA METADE DO SÉCULO XXEste artigo tem como objeto de estudos a série “Brasília”, de Daisy Bréscia. Publicada na década de 1960, a série compreende cinco obras: uma cartilha/livro intermediário e quatro livros de leitura. O título dos livros foi uma forma, pensada pela autora, de homenagear a inauguração da nova capital do país. Objetiva-se apresentar algumas características dessa série, analisando suas materialidades e ideários no que concerne ao ensino de leitura no contexto do Brasil na segunda metade do século XX. Os resultados da análise indicam que os livros e respectivas lições de Bréscia, embora apresentem características próprias, aproximam-se, tanto gráfica quanto metodologicamente, das obras para ensinar leitura produzidas naquele momento histórico.Ana Raquel Costa Dias; Juliano Guerra Rocha

Reading (process); Context (archaeology); Ethnography; Capital (architecture); Object (grammar); Art; Humanities; Sociology; Philosophy; History

2026-06-24https://doi.org/10.47249/rba20261059Revista Brasileira de Alfabetização 20261Diffusion Tensor Imaging Along the Perivascular Space (DTI-ALPS) as a Neuroimaging Biomarker of Glymphatic Function in Neurodegenerative Diseases: A Systematic ReviewThe glymphatic system has been proposed as a brain-wide pathway that promotes the exchange between cerebrospinal and interstitial fluids and facilitates the clearance of metabolic waste products, including amyloid-β and tau proteins. Diffusion tensor imaging analysis along the perivascular space (DTI-ALPS) has emerged as a non-invasive magnetic resonance imaging technique proposed to indirectly assess glymphatic-related fluid dynamics. This systematic review evaluated the methodological consistency and clinical applicability of the ALPS index in neurodegenerative diseases. A structured search of PubMed (MEDLINE) and Web of Science identified human studies published up to January 2026 investigating DTI-ALPS in neurodegenerative conditions. Data regarding study populations, MRI acquisition parameters, image-processing methods, statistical approaches, and clinical associations were extracted and synthesized. Ten studies met the inclusion criteria. Across studies, lower ALPS index values were generally associated with cognitive impairment, amyloid burden, and disease severity, particularly in Alzheimer's disease. Several studies incorporated multimodal biomarkers, including amyloid positron emission tomography and cerebrospinal fluid markers, thereby improving the biological interpretation of DTI-ALPS findings. However, substantial methodological heterogeneity was identified across studies, including variability in region-of-interest placement, diffusion acquisition protocols, and image-processing pipelines. Furthermore, the interpretation of diffusivity metrics as direct measures of glymphatic flow remains controversial. Current evidence suggests that DTI-ALPS may represent a promising non-invasive imaging marker of glymphatic-related alterations; however, its biological specificity and clinical applicability remain insufficiently established. Standardized acquisition protocols, harmonized analytical pipelines, and longitudinal multicenter studies are required to clarify its role in neurodegenerative disease research.Raphael Lopes Olegário; Otávio de Tolêdo Nóbrega; N. Almeida; Dany Alexis Sobarzo Soto; Ciro José Brito; Diógenes Diego de Carvalho Bispo; Felipe von Glehn; Arsenio Páez; Thien Thanh Dang‐Vu; Einstein Francisco Camargos

Diffusion MRI; Glymphatic system; Positron emission tomography; Neuroimaging; Magnetic resonance imaging; Biomarker; Tractography; Cerebrospinal fluid; Perivascular space; Neuroscience; Medicine; Neurodegeneration; Pathology; Interstitial fluid; Disease; Human brain; Amyloid (mycology); Alzheimer's disease

2026-06-26https://doi.org/10.3390/ijms27135758International Journal of Molecular Sciences 20261Carga da doença, social e econômica do tabagismo no Brasil e impacto do aumento de impostos para a economia e para a redução da morbimortalidadeThis study aimed to estimate the disease, social, and economic burden of smoking in Brazil in 2022 and to predict the benefits of tax increases, including its effects of the illegal market. A probabilistic Markov microsimulation model was applied in which individuals aged 35 years or older were followed in hypothetical cohorts and quantified deaths, health events, the direct cost of medical care, and the indirect cost due to productivity losses. A model to estimate health and economic gains from 10-year tax increase scenarios was developed. Data on smoking prevalence, the Brazilian demographic structure, mortality, and morbidity were obtained from official databases and the literature. The used health resources were obtained from the literature and consultations with specialists. Smoking caused 174,000 deaths and 5.7 million years of life lost due to premature death and disability. Its economic burden totaled BRL 153 billion, of which BRL 67 billion was attributed to direct costs and BRL 45 billion to indirect costs. The cost of informal caregivers equaled BRL 41 billion. In the scenario with the illegal market for tobacco products, a 50% increase in the price of cigarettes may generate economic benefits of BRL 161 billion in 10 years. The current tax reform currently in Brazil may constitute a permanent pricing and tax policy.Márcia Pinto; Ariel Bardach; Agustín Casarini; Federico Augustovski; Alfredo Palacios; Natalia Espínola; Márcia Gisele Santos da Costa; K. Senna; Ana Clara de Moraes; Vera Luiza da Costa e Silva; Felipe Lacerda Mendes; Cristiane Galhardo Ferreira Vianna; Ana Paula Leal Teixeira; Andrés Pichón-Rivière

Health insurance; Public policy; Social benefits; Political science; Humanities; Business

2026-01-01https://doi.org/10.1590/0102-311xpt002425Cadernos de Saúde Pública 20261Optimizing tourniquet pressures in knee arthroscopy: an international survey on current practice and a double-blind randomized trialBACKGROUND & PURPOSE: Pneumatic tourniquets improve surgical visualization during knee arthroscopy, but fixed high pressures may increase postoperative pain. This study investigated whether a minimal effective individualized occlusion pressure (MEIOP), calculated as limb occlusion pressure plus a safety margin, maintains surgical field quality while reducing pain compared to a standardized occlusion pressure (SOP). METHODS: A preliminary survey of 79 orthopaedic surgeons identified 350 mmHg as the routine SOP. In a subsequent double-blind randomized clinical trial, patients undergoing elective knee arthroscopy were assigned to SOP (350 mmHg) or MEIOP, defined as Doppler-derived limb occlusion pressure plus a safety margin (mean ≈ 230 mmHg). Outcomes included surgical field quality, postoperative using a visual analog scale (VAS) up to 15 days, overall 15-day pain perception, and analgesic consumption. RESULTS: Both groups achieved 100% excellent surgical field ratings. Pain trajectories differed significantly between groups over time (group × time interaction, p = 0.022). The MEIOP group experienced significantly lower pain at discharge (~ 6 h; p = 0.013, d = 1.14) and lower overall 15-day pain perception (p = 0.043, d = 0.89). Analgesic consumption showed a consistent descriptive trend favoring MEIOP throughout follow-up. CONCLUSION: This proof-of-concept study suggests that individualizing tourniquet pressure using predefined MEIOP protocol preserves satisfactory surgical visualization and is associate with lower postoperative pain compared with a standard high-pressure protocol. This trial was prospectively registered at the Brazilian Clinical Trials Registry (ReBEC; RBR-4xd6cxm).Heber Oliveira Cardoso Filho; Bruno Fajardo; Rodrigo Hohl; Vinicius Novais Rocha; Manoel Carlos Couto Araújo; Rhaí A. Arriel; Gabriel Dias Mendes Andrade; Moacir Marocolo

Randomized controlled trial; Tourniquet; Visual analogue scale; Orthopedic surgery; Occlusion; Analgesic; Clinical trial; Knee pain; Medicine; Anesthesia; Physical therapy; Surgery; Quality of life (healthcare); Pain assessment; Arthroscopy

2026-06-27https://doi.org/10.1007/s00264-026-06926-9International Orthopaedics 20261ENSINO HÍBRIDO: A NOVA SALA DE AULAEste artigo teve por objetivo analisar o ensino híbrido na nova sala de aula, considerando seu conceito, suas potencialidades para a aprendizagem e os desafios de sua implementação no contexto pós-pandemia. O tema foi tratado a partir da compreensão de que a articulação entre atividades presenciais e digitais reconfigurou práticas pedagógicas, tempos, espaços e formas de participação discente. Metodologicamente, realizou-se uma pesquisa bibliográfica de caráter exploratório e descritivo, baseada na busca, leitura, seleção, organização e interpretação de produções acadêmicas pertinentes ao objeto investigado. A análise dos estudos permitiu concluir que o ensino híbrido favoreceu maior flexibilidade dos percursos formativos, ampliação das possibilidades de acesso ao conhecimento, estímulo à autonomia dos estudantes e fortalecimento de práticas colaborativas, desde que sua organização tivesse sido orientada por planejamento pedagógico, mediação qualificada e condições institucionais adequadas. Também se verificou que sua implementação encontrou obstáculos ligados à imprecisão conceitual, às dificuldades de adaptação de professores e estudantes e às desigualdades estruturais que limitaram a efetividade das propostas em alguns contextos. Desse modo, o estudo demonstrou que o ensino híbrido não se restringiu ao uso de tecnologias, mas envolveu uma reorganização mais ampla do processo educativo. Por fim, identificou-se a necessidade de novas pesquisas sobre avaliação, formação docente, infraestrutura e efeitos do híbrido em diferentes etapas de ensino.Edson Severino Leal; Leda Borges Vieira; Wilian Ricardo Costa; Dionys Morais dos Santos; Manoel Pessoa da Silva

Context (archaeology); Theme (computing); Scope (computer science); Perspective (graphical); Autonomy; Exploratory research; Qualitative research; Thematic analysis; Work (physics); Pedagogy; Sociology; Object (grammar); Focus group; Higher education; Action (physics); Psychology

2026-06-27https://doi.org/10.46550/anbsza11Missioneira 20261SELIS: A smart energy & lighting infrastructure simulatorThis paper presents the software architecture and design of SELIS: A Smart Energy & Lighting Infrastructure Simulator. SELIS is a simulation-based framework designed to support the planning, operation, and modernization of public lighting systems. Its architecture integrates clustering algorithms, financial analysis, and communication components in a modular and reproducible environment. SELIS allows users to explore design alternatives, evaluate economic impacts, and test operational strategies without costly pilot deployments. Validated with a Brazilian case study but adaptable to other contexts, SELIS provides municipalities, utilities, and researchers with a practical, extensible, and open-source tool for sustainable smart city development.Amanda O. Timotheo; Humberto A. Guimarães; Iago Z. Biundini; Mario A. R. Dantas; Miriam A.M. Capretz; Leonardo M. Honório

Modular design; Architecture; Software; Modernization theory; Efficient energy use; Energy (signal processing); Smart city; Cluster analysis; Software architecture; Computer science; Embedded system; Systems engineering; Test (biology); Smart lighting; Building automation; Sustainable energy; Virtual machine; Software engineering; Systems architecture; Smart grid

2026-06-27https://doi.org/10.1016/j.softx.2026.102837SoftwareX 20261Opioid-sparing analgesia with clonidine versus fentanyl in inguinal hernia repair: a randomized clinical trialPoolo Marcos Fernandes de Souza; Priscila Carvalho Morais; Saul Flores Santos; Luiz Ronaldo Alberti

Fentanyl; Clonidine; Sedation; Inguinal hernia; Analgesic; Randomized controlled trial; Adverse effect; Medicine; Anesthesia; Abdominal surgery; Visual analogue scale; Surgery; Hernia; Clinical trial; Morphine

2026-06-27https://doi.org/10.1007/s10029-026-03768-7Hernia 20261Optimization of steel-UHPC composite girder bridges for lightweight and eco-efficient designInfrastructure construction demands fast and industrialized methods to deliver more sustainable and durable solutions. The application of composite structures using Ultra-High-Performance-Concrete (UHPC) emerges as a potential strategy to enhance structural efficiency, extend service life, reduce environmental impacts, and design lightweight structures. However, there is still a lack of studies applying automated optimization techniques to steel-Ultra-High-Performance-Concrete (UHPC) for those purposes. In bridge projects, the superstructure alone accounts for approximately 50% of carbon dioxide (CO₂) emissions during material supply, transport, and manufacturing. In this context, this study aims to replace an ordinary concrete slab with UHPC, and the composite section is optimized using heuristic optimization combined with a nonlinear finite element model. The optimization resulted in a weight reduction of up to 38% and a 4% smaller carbon footprint than the original section. Thus, the solutions will have an extended life cycle with a smaller carbon footprint, combined with an accelerated construction process due to more lightweight components.Gustavo Moura; Vinícius Parolin; Paula O. Ribeiro; Pablo A. Krahl

Finite element method; Carbon footprint; Service life; Composite number; Bridge (graph theory); Slab; Superstructure; Process (computing); Girder; Structural engineering; Computer science; Heuristic; Engineering; Life-cycle assessment; Girder bridge; Genetic algorithm; Nonlinear system; Reduction (mathematics)

2026-06-27https://doi.org/10.1016/j.istruc.2026.112496Structures 20261Paired METAR/SPECI Dataset and Analysis Code — Remote Aerodrome Flight Information Service Shadow-Mode Validation at SBMI (2025)Dataset and Python analysis code supporting the article "Shadow-Mode Meteorological Concordance Between Remote and On-Site Observation at a Brazilian Regional Aerodrome" (Journal of Aerospace Technology and Management, manuscript JATM-2026-0039). Contains 749 paired METAR/SPECI messages from 118 operational days (17 March – 28 November 2025) at the SBMI aerodrome (Maricá, Rio de Janeiro, Brazil), and the scripts for the concordance analysis. Version 1.1 adds a script reproducing the Table 2 intraclass correlation coefficients (compute_icc.py), a transparent register of known data anomalies (data_anomalies.csv), and a README documenting workbook provenance and reproducibility; the supporting-article title is aligned and raw observational records are unchanged.Guilherme Vieira Monteiro Amadeu

Scripting language; Python (programming language); Concordance; Aerospace; Raw data; Code (set theory); Computer science; Database; Meteorology; Remote sensing; Data mining; Table (database); Web service

2026-06-27https://doi.org/10.5281/zenodo.20976599Zenodo (CERN European Organization for Nuclear Research) 20261AS TECNOLOGIAS COMO INTERFACE NO PROCESSO DE APRENDIZAGEM DE ALUNOS DO ENSINO MÉDIO EM ESCOLAS ESTADUAIS EM URUÇUÍ-PIEste estudo aborda as tecnologias como interface no processo de aprendizagem de alunos do ensino médio em escolas estaduais no município de Uruçuí-PI, considerando o contexto contemporâneo em que os recursos digitais vêm assumindo papel cada vez mais relevante nas práticas pedagógicas. A pesquisa teve como objetivo analisar de que forma as tecnologias estão sendo inseridas no ambiente escolar e como podem contribuir para o processo de ensino e aprendizagem, levando em conta desafios, possibilidades e percepções dos sujeitos envolvidos. Metodologicamente, trata-se de uma investigação de abordagem mista, com caráter descritivo e exploratório, desenvolvida por meio de revisão bibliográfica e pesquisa de campo. A revisão teórica foi realizada a partir de produções científicas disponíveis no Portal de Periódicos da CAPES, Google Acadêmico e SciELO, com recorte temporal de 2023 e 2024. A pesquisa de campo ocorreu em escolas estaduais de ensino médio de Uruçuí-PI, envolvendo professores, alunos e gestores escolares. Para a coleta de dados, utilizaram-se questionários estruturados e entrevistas semiestruturadas, possibilitando a articulação entre informações objetivas e percepções sobre o uso das tecnologias no contexto educacional. A análise dos dados permitiu compreender que a inserção dos recursos tecnológicos na escola representa uma possibilidade significativa de inovação pedagógica, embora ainda existam desafios relacionados à infraestrutura, à formação docente e à efetivação de práticas pedagógicas mais integradas à cultura digital. O estudo contribui para a reflexão sobre o papel das tecnologias na educação básica e para o fortalecimento de práticas pedagógicas mais significativas, dinâmicas e contextualizadas.L da PG da Silva; Eduardo Pessoa dos Reis; Fernanda Aparecida Motta Carvalho; Erislene Paiva da Silva; Maria das Mercês de Sousa; Denise de Oliveira Barreto

Context (archaeology); Curriculum; Process (computing); Work (physics); Humanities; Sociology; Political science; Pedagogy

2026-06-28https://doi.org/10.70773/revistatopicos/782232536Revista Tópicos. 20261Targeting the diaphragm during weaning from mechanical ventilationBruno Valle Pinheiro; Lídia Maria Carneiro da Fonseca; Erich Vidal Carvalho

Mechanical ventilation; Diaphragm (acoustics); Weaning; Mechanical ventilator; Ventilation (architecture); Respiratory system; Medicine; Anesthesia; Surgery; Diaphragm muscle

2026-06-01https://doi.org/10.21037/jtd-2026-1163Journal of Thoracic Disease 20261Convolutional Neural Networks for Signal Reconstruction in High-Energy CalorimetryParticle accelerators are complex facilities that collide particles at extreme high speed, aiming to discover new physics. In this context, high-energy calorimeter systems play a crucial role, as they provide the particle energy quantity, which is important information for the potential new discoveries. Therefore, this work evaluates the performance of the commonly used Optimal Filter (OF) method and several Convolutional Neural Network (CNN) architectures in reconstructing the amplitude and phase of simulated signals that represent the response pulses produced by high-energy calorimeters. The comparison is conducted using quantitative metrics—including RMS, MAE, MedAE, and Coefficient of Determination. The results show that different CNN architectures exhibit varying performances depending on the calorimeter cell occupancy rate but generally outperform the typical linear OF method, providing more accurate signal reconstructions. Considering all evaluated occupancy levels (10%, 50%, 80%, and 100%), the CNN-based approaches achieved an average improvement of approximately 79% in amplitude RMS and 62% in amplitude standard deviation when compared to the OF method. For phase estimation, the CNNs achieved improvements of approximately 26% for both RMS and standard deviation metrics. Although the proposed strategy requires a large execution time due to the training process across multiple folds, these findings indicate that CNNs are promising alternatives for calorimeter energy reconstruction, particularly in high-occupancy conditions such as those expected for high-luminosity experiments.Diogo Alves Cardinot; B. S. Peralva; Gustavo Barbosa Libotte; L. Manhaes de Andrade Filho

Calorimeter (particle physics); Convolutional neural network; Amplitude; Energy (signal processing); SIGNAL (programming language); Phase (matter); Standard deviation; Artificial neural network; Computer science; Algorithm; Filter (signal processing); Process (computing); Artificial intelligence; Pattern recognition (psychology); Transformation (genetics); Calorimetry; Work (physics)

2026-06-26https://doi.org/10.3390/app16136414Applied Sciences 20261Gamification and Diversity in STEM: Analysing Participation and Engagement at the Brazilian Women in Information Technology WorkshopANNA BEATRIZ MARQUES; Luciana C. Salgado; Alessandreia de Oliveira; Aleteia P. F. Araujo; Mirella M. Moro; Luciana B. Frigo

Diversity (politics); Information technology; Information system; Information and Communications Technology; Work (physics); Public relations; Sociology; Knowledge management

2026-04-27https://doi.org/10.1109/educon67543.2026.11574251 20261Educação e trabalho interprofissional em saúde: perspectiva de docentes de uma instituição pública de ensino superior de Minas GeraisObjetivou-se compreender a perspectiva de docentes da área da Saúde de uma instituição pública de ensino superior de Minas Gerais a respeito da Educação e Trabalho Interprofissional em Saúde. Trata-se de um estudo qualitativo, com grupos focais e análise de conteúdo temática, do qual emergiram cinco categorias: (I) A colaboração e integração como significados da Educação Interprofissional em Saúde, (II) O trabalho em equipe constrói-se no desenvolvimento de habilidades relacionais e reconhecimento dos diferentes papéis profissionais, (III) As metodologias ativas de ensino-aprendizagem-avaliação são ferramentas para a Educação Interprofissional, (IV) O compartilhamento de espaços e a integração ensino-serviço-comunidade impulsionam a Educação Interprofissional e (V) Desafios políticos e estruturais institucionais fragilizam a implementação da Educação Interprofissional. Os achados reforçam a necessidade de implementar estratégias pedagógicas e institucionais para fortalecer a Educação Interprofissional e orientar a formação de profissionais de Saúde para atuação interprofissional.Letícia Cândida da Cunha; Carolyne Reduzina Queirós; Meirele Rodrigues Gonçalves; Lélia Cápua Nunes; L Bonomo

Work (physics); Context (archaeology); Initial training; Sociology; Humanities; Political science

2026-01-01https://doi.org/10.1590/interfrace.250112Interface - Comunicação Saúde Educação 20261A Novel Newmark Family of Fourth-Order Accurate Algorithms with Complex Sub-Steps for Structural DynamicsA new family of fourth-order accurate time integration schemes is developed by introducing two complex time sub-steps into the classical Newmark family of second-order algorithms. These sub-steps consist of a pair of complex conjugate numbers, enabling the triangularization of a complex-valued effective stiffness matrix. The proposed formulation can be easily implemented in existing codes with only minor modifications to the standard Newmark algorithm. The solution is composed of both real (physical) and imaginary components. The real component provides fourth-order accuracy even in the presence of external loads and physical damping, while the imaginary component offers additional insight into the distribution of numerical errors, an original feature not previously reported for implicit formulations. Compared to the classical Newmark method with a time-step size four times smaller, the proposed scheme exhibits significantly lower numerical dissipation and dispersion errors. Furthermore, the sub-step procedure extends the critical time step of conditionally stable members of the Newmark family by a factor of 3. The numerical analysis performed in the proposed time integration method, along with the results obtained for dynamic structural problems, including a complex three-dimensional (3D) application, clearly demonstrate that the method outperforms both Fung’s fourth-order complex scheme and the classical Newmark approach in terms of accuracy.Yargo P. Souza; Felipe S. Loureiro; Delfim Soares; Walnório Graça Ferreira; W.J. Mansur

Newmark-beta method; Conjugate gradient method; Component (thermodynamics); Dissipation; Stiffness; Numerical analysis; Complex conjugate; Basis (linear algebra); Algorithm; Mathematics; Applied mathematics; Computer science; Scheme (mathematics); Simple (philosophy); Computation; Numerical integration

2026-06-29https://doi.org/10.3390/dynamics6030024Dynamics 20261Acute fatigue and recovery responses to resistance training performed to momentary muscular failure: an exploratory multimodal physiological studyThis study compared the effects of a full-body resistance training session performed to momentary muscular failure (RTF) or non-failure (RTNF) on mechanical, perceptual, metabolic, neuromuscular, cardiovascular, and autonomic responses in trained men. In a randomized crossover design, six men (25.5 ± 3.3 years; 77.8 ± 6.2 kg; 174.5 ± 5.1 cm) completed two sessions of six exercises. RTF sets were performed to failure at 100% 10-repetition maximum (10RM), while RTNF sets consisted of 10 repetitions at 85% 10RM. Perceptual, metabolic, hormonal, cardiovascular, and autonomic responses, alongside markers of tissue damage and neuromuscular function, were monitored for 72 h post-RT. Data were analyzed via Generalized Estimating Equations. RTF induced greater perceived exertion (p < 0.001) with fewer repetitions per set and reduced volume in specific movements (p < 0.05), despite similar total session volume (p > 0.05). RTF elicited higher lactate (p = 0.003) and cortisol (p < 0.001). RTF exacerbated tissue damage markers (creatine kinase and lactate dehydrogenase, p < 0.001) and soreness (p < 0.05), leading to delayed countermovement jump recovery (p < 0.001) through 72 h. Conversely, RTNF demonstrated faster perceived recovery (p < 0.001) and similar autonomic preservation (p > 0.05). Acute cardiovascular strain was higher in RTF (p < 0.05), with no residual effects. Although the small sample size warrants cautious interpretation of inferential statistics, RTF delays recovery without acute functional benefits. Since proximity-to-failure drives physiological stress, RTNF proves to be more efficient and sustainable.João Guilherme Vieira; Bruno Pascoalini da Silva; Yuri Campos; Marcelo Ricardo Dias; Pedro Lima Souza; Victor S. de Queiros; Okan Kamiş; Michal Wilk; Krzysztof Fostiak; Jaworski Łukasz; Jefferson da Silva Novaes; Jeferson Macedo Vianna

Crossover study; Resistance training; Muscle damage; Rating of perceived exertion; Blood lactate; Muscle fatigue; Cycle ergometer; Heart rate; Perceived exertion; Medicine; Physical therapy; Physical medicine and rehabilitation; Cardiology; Internal medicine; Session (web analytics); Overtraining; Tilt table test

2026-06-29https://doi.org/10.1038/s41598-026-59113-6Scientific Reports 20261CONTRA-GEOGRAFIA DO AXÉ: ESCREVIVÊNCIA, CONTRACOLONIALIDADE E A DEVOLUÇÃO SOCIAL AOS POVOS DE TERREIRO DE RIBEIRÃO PRETO (SP)Este relato de experiência analisa o planejamento, a curadoria litúrgico-espacial e os desdobramentos da Sessão Solene “Àgbà”, intervenção de reconhecimento oficial dos povos de terreiro em Ribeirão Preto - SP. Como ação de devolução social e de justiça epistêmica, o evento converteu a pesquisa etnográfica em um instrumento de reparação histórica e de salvaguarda jurídica. Fundamentado na escrevivência (Evaristo, 2007), o estudo discute a agência das lideranças afrorreligiosas na consolidação de contra-geografias do axé frente à hegemonia do agronegócio regional. Examina-se também a eficácia de traduzir os dados em resolução legislativa, homenageando as nações (Ketu, Angola e Jeje) do candomblé e subvertendo o silenciamento institucional.Ronan da Silva Parreira Gaia; João Pedro Ferreira; Ana Luiza Alves Pereira; Mariana Luísa da Costa Lage

Field (mathematics); Context (archaeology); Set (abstract data type); Relation (database); Social life; Sociology; Humanities

2026-06-26https://doi.org/10.22289/sg.v7n1a88Scientia Generalis 20261Magnetic Resonance Imaging/Diffusion-Weighted Imaging-Guided Versus Perfusion-Guided Intravenous Thrombolysis with Alteplase Beyond 4.5-Hour Window: a Network Meta-Analysis of Randomized Controlled TrialsOcílio Ribeiro Gonçalves; Gabriel Caruso Novaes Tudella; Leonardo Januário Campos Cardoso; Giovana Menegucci; Augusto Utida Klostermann; Luís Felipe Porto; Carlos Daniel Santiago Azevedo; Anderson Matheus Pereira da Silva; Társis Vinícius Cronemberger; Jagkirat Singh; Wei Jun Lee; Leonardo Di Cosmo; Mariana Letícia de Bastos Maximiano; Ahmet Günkan; Thanh Nguyen; Adam A. Dmytriw; Guillaume Turc; Frédéric Clarençon; Luca Scarcia

Thrombolysis; Magnetic resonance imaging; Randomized controlled trial; Perfusion scanning; Stroke (engine); Clinical trial; Perfusion; Fibrinolytic agent; Medicine; Radiology; Surgery; Computed tomography; Significant difference; Intracerebral hemorrhage

2026-06-29https://doi.org/10.1007/s00062-026-01693-xClinical Neuroradiology 20261Retinal Sensitivity Assessed by Microperimetry and Its Topographic Correlation with Macular Structure by Optical Coherence Tomography Following Macular Hole Surgery: a cross-sectional studyRodrigo Pegado; Gabriel Castilho Sandoval Barbosa; Luciana Virgínia Ferreira Costa-Cunha; Leandro Cabral Zacharias; Rony Carlos Preti; Mário Luiz Ribeiro Monteiro; Leonardo Provetti Cunha

Microperimetry; Optical coherence tomography; Macular hole; Vitrectomy; Retinal; Visual acuity; Epiretinal membrane; Pars plana; Medicine; Ophthalmology; Diabetic retinopathy; Maculopathy; Foveal; Tamponade

2026-06-29https://doi.org/10.21203/rs.3.rs-10082290/v1Research Square 20261From the Petri dish to the patient’s bedside: interpreting Trichosporon asahii positive urine cultures in hospitalized patientsUrinary tract infections (UTIs) are common and traditionally linked to bacteria; however, yeasts— particularly Trichosporon asahii — have emerged as opportunistic pathogens in immunocompromised and hospitalized patients. The presence of fungi may represent either colonization or infection, and the understanding of immune bases can help in this differentiation. 19 T. asahii isolates from urine cultures of hospitalized patients were analyzed and subjected to antifungal susceptibility testing. Urine samples underwent routine analysis (appearance, protein, specific gravity, pH) and flow cytometry. Clinical and sociodemographic data were obtained from electronic medical records. Results: Of the 19 patients, 11 were catheterized and 8 non-catheterized, with a predominance of males aged ≥60 years. Most were admitted to the ICU (n=13), especially in the catheterized group. A high mortality rate was observed, particularly among catheterized patients (81.1%). Urinalysis demonstrated frequent abnormalities, such as proteinuria, hematuria, and leukocyturia, suggesting an active local immune response. In association with positive cultures for T. asahii , these findings reinforce the hypothesis of active urinary tract infection. The results highlight the relevance of accurate laboratory diagnosis of this pathogen and the implementation of appropriate therapeutic strategies based on antifungal susceptibility testing, clinical expertise, and pharmacokinetic and pharmacodynamic principles. These measures are essential to optimize clinical management, improve therapeutic outcomes, and reduce mortality associated with urinary tract infections caused by multidrug-resistant T. asahii.Letícia Rebello Machado; Yasmim Passos Lima; André Netto Bastos; Victor Quinet de Andrade Bastos; Lucas Quinet de Andrade Bastos; Ricardo Villela Bastos; Vanessa Cordeiro Dias

Urinalysis; Urinary system; Urine; Trichosporon; Pathogen; Immune system; Pharmacodynamics; Antifungal; Medicine; Clinical significance; Antibiotics; Internal medicine; Immunology; Intensive care medicine; Mortality rate; Biology

2026-06-29https://doi.org/10.3389/fimmu.2026.1866019Frontiers in Immunology 20261Costurando histórias: Relatos de montagem no documentário brasileiro contemporâneoTainá Moraes

Context (archaeology); Margin (machine learning); Consumption (sociology)

2026-06-29https://doi.org/10.25768/1646-477x.n39.13Universidade da Beira Interior 20261Prevalência do uso de maconha e fatores associados entre estudantes de uma universidade do leste de Minas Gerais, BrasilThe aim of this article is to investigate the prevalence of marijuana use and associated factors among students at a university in eastern Minas Gerais, Brazil. A cross-sectional study was conducted with university students from six health courses. The participants completed two questionnaires: the first included sociodemographic questions, and the second contained questions to screen for consumption of tobacco, alcohol, and other drugs. The association between the variables was analyzed using a logistic regression model. The lifetime prevalence of marijuana use was 19.62%. Students of non-white race/color were less likely to use marijuana (OR: 0.61; 95%CI: 0.37-0.99). Students who lived in a dormitory, with friends, or alone (OR: 2.65; 95%CI: 1.47-4.79), had a bad relationship with their father, or had no relationship (OR: 2.25; 95%CI: 1.28-3.95), and those who did not have a religion (OR: 6.38; 95%CI: 3.38-12.06) were more likely to use marijuana. Marijuana use among students was associated with the following explanatory variables: race/color, form of residence, relationship with father, and religion. These results contribute to indicating a priority group for defining health and damage prevention actions.João José Luiz Campos; Arthur Félix Iácono Fullone; Lélia Cápua Nunes; Eulilian Dias de Freitas; Camila Teixeira Vaz

Attendance; Exploratory research; Qualitative research; Residence; Population; Multivariate analysis; Feeling; Gerontology; Medicine; Psychology; Humanities; Demography

2026-01-01https://doi.org/10.1590/1413-81232026315.06542024Ciência & Saúde Coletiva 20261Missed nursing care in Brazilian hospitalsIntroduction: Missed nursing care refers to nursing activities that are omitted or delayed; it is recognized as a global issue with potential consequences for patient safety, including an increased risk of adverse events. Universal access healthcare is predominant in the Brazilian health system. Aim: To describe missed nursing care and its reasons in Brazilian hospitals. Methods: A multicenter descriptive study was conducted in three teaching hospitals at different Brazilian regions, involving 429 nursing professionals. Data were collected using the MISSCARE-BRASIL instrument. Results: The most missed nursing care activities were ambulation (57.1%) and participation in interdisciplinary team discussions. The main reasons for missed nursing care were unexpected increases in patient volume and/or acuity (76.5%), and inadequate staffing (75.6%), predominantly within the material resources (μ = 2.85) and labor resources (μ = 2.76) domains. Multivariate analysis showed that staffing inadequacy and job dissatisfaction (p < 0.001) were associated with missed nursing care. Conclusion: Missed nursing care in Brazilian hospitals is associated with limitations in human and material resources, workload overload, staffing inadequacy, and job dissatisfaction, highlighting the need for staffing models adjusted to patient acuity, improved resource management, and organizational strategies to enhance job satisfaction and care quality.Diana Albuquerque Alvim de Paula; Adrize Rutz Porto; Maria Cristina Soares Rodrigues; Paula Roberta Silva Araújo; Lucas da Silva Dellalibera; Nádia Fontoura Sanhudo; Hérica Silva Dutra

Staffing; Workload; Nursing care; Nursing Outcomes Classification; Primary nursing; Skill mix; Health care; Team nursing; Job satisfaction; Nursing; Medicine; Nurse education; MEDLINE; Patient safety; Nursing research; Human resources; Patient satisfaction; Descriptive research; Nursing Assistant; Ambulatory care nursing

2026-06-29https://doi.org/10.32725/kont.2026.041Kontakt 20261Ensino de metabolismo energético por meio de alimentos do cotidianoTeaching about energy metabolism in high school is often considered complex and difficult to understand. Therefore, this study aimed to apply and evaluate a didactic sequence based on a potentially meaningful teaching unit, using an active methodology where students relate everyday foods to energy metabolism. This work was applied to third-year high school students in the Youth and Adult Education program in Governador Valadares, MG. The method used was developed in 8 stages, the first being the definition of the topic. The following stages involved the application of the didactic sequence with experimental classes using science and computer labs. The final stage of the potentially meaningful teaching unit was a comprehensive evaluation. Students were assessed individually and collectively. Qualitatively, the result was satisfactory, as students participated throughout the sequence, asking questions and giving their opinions after each discovery. In the quantitative assessment, the scores for the initial and final concept maps were 38.78 ± 19.74 and 73.46 ± 23.94, respectively, with a p-value < 0.001. This teaching sequence made it possible to verify that the understanding of basic concepts related to energy metabolism was enhanced. We can conclude that this teaching sequence contributed to improving students' understanding of energy metabolism, and is suitable for assisting in the learning of topics considered complex by students.R Medina; Maísa Silva

Energy (signal processing); Sequence (biology); Meaningful learning; Teaching method; Work (physics); Mathematics education; Computer science; Pedagogy; Order (exchange); Psychology

2026-06-29https://doi.org/10.47456/xz0vdf61Kiri-Kerê - Pesquisa em Ensino 20261Impact of Prolonged and Unsupplemented Vegan Diet on Retinal Structure and Visual FunctionVitamin B12-deficiency nutritional optic neuropathy (NON) is a potentially preventable cause of permanent visual loss that may occur in individuals following prolonged unsupplemented vegan diets. This cross-sectional observational study assessed peripapillary retinal nerve fiber layer (pRNFL) and ganglion cell complex (GCC) thickness using optical coherence tomography (OCT) in vegan patients with permanent visual loss secondary to vitamin B12-deficiency NON and compared the findings with those of age-matched healthy controls. All participants underwent OCT and standard automated perimetry, and clinical data, dietary history, duration of diet and symptoms, serum vitamin B12 levels, best-corrected visual acuity, mean deviation values, and pRNFL and GCC measurements were evaluated. A total of 22 eyes from 11 vegan patients and 22 eyes from 11 healthy controls were included. Vegan patients showed significant temporal pRNFL thinning and diffuse GCC thinning compared with controls. Significant correlations were observed between the duration of the vegan diet and symptoms, the severity of visual field loss, and several OCT parameters, particularly GCC thickness. Patients with permanent visual loss due to vitamin B12-deficiency nutritional optic neuropathy associated with prolonged unsupplemented vegan diets demonstrated marked temporal pRNFL thinning and diffuse macular GCC loss on OCT, with GCC measurements correlating with symptom duration. These findings support the usefulness of OCT for documenting structural damage in established nutritional optic neuropathy. However, larger longitudinal studies including asymptomatic or early symptomatic vegan individuals are needed to determine whether OCT can detect early neuroaxonal loss or predict visual outcomes.Leonardo Provetti Cunha; Jayana Rodrigues; Thiago Cardoso Vale; Luciana Virgínia Ferreira Costa-Cunha; Kenzo Hokazono; Mário Luiz Ribeiro Monteiro

Retinal; Function (biology); Visual acuity; Retina; Vegan Diet; Medicine

2026-06-29https://doi.org/10.1080/01658107.2026.2692479Neuro-Ophthalmology 20261Biphasic finite element analysis of pullout-controlled behavior in recycled steel fiber reinforced concreteThe structural application of recycled tire steel fibers in concrete remains limited by uncertainties regarding their post-cracking efficiency and by the absence of predictive numerical frameworks capable of representing their structural behavior. This study investigates whether recycled steel fibers can provide structurally efficient reinforcement mechanisms comparable to industrial fibers and proposes a numerical framework capable of reproducing the governing fiber–matrix interaction mechanisms. An experimental–numerical investigation was conducted on recycled fiber reinforced concrete (RFRC) combining mechanical characterization and biphasic finite element modeling. The recycled fibers presented high geometric variability, with lengths ranging from 1.65 to 61.64 mm and diameters from 0.06 to 0.53 mm, promoting intrinsic hybridization and multiscale crack-bridging mechanisms. RFRC with 0.6% fiber content achieved a 55% increase in splitting tensile strength compared to plain concrete and residual flexural strengths f R,1 and f R,4 of 2.91 MPa and 2.07 MPa, respectively, comparable to industrial fiber reinforced concrete produced with similar fiber contents and compressive strengths (∼30–35 MPa). Pullout tests indicated average bond strengths of approximately 12 MPa, with pullout governing the failure mechanism due to the rough surface morphology and high tensile strength of recycled fibers. The proposed biphasic model accurately reproduced the experimental load–displacement behavior, crack evolution, stress redistribution, and residual strength by explicitly incorporating the statistical variability of fiber geometry and orientation. The results demonstrate that recycled tire steel fibers can provide efficient pullout-controlled reinforcement mechanisms when appropriate selection and processing procedures are adopted, supporting future design development and broader implementation of circular solutions in concrete construction.Luiza Campos Coelho; M. Milani; Paula de Oliveira Ribeiro; Flávio de Andrade Silva; Pablo Augusto Krahl

Ultimate tensile strength; Finite element method; Fiber; Flexural strength; Reinforcement; Compressive strength; Fiber-reinforced concrete; Characterization (materials science); Residual; Materials science; Composite material; Structural engineering; Residual strength; Residual stress; Stress (linguistics); Bond strength; Synthetic fiber; Material properties

2026-06-29https://doi.org/10.1016/j.istruc.2026.112477Structures 20261Metabolic profiling of Piper regnellii (Piperaceae) and its dual anti-inflammatory and anti-urolithiatic effectsEthnopharmacological relevance Piper regnellii (“Pariparoba”), is a shrub widely employed in traditional medicine, particularly in the form of leaf infusions or decoctions. These preparations are traditionally used for the treatment of wounds, infections, edema, skin lesions, pain, and other inflammatory conditions. Aim of the study Building upon traditional reports of P. regnellii associated with inflammatory conditions, this study combined chemical profiling and bioactivity assays to evaluate its inhibitory effects on key inflammatory mediators (PGE 2 and LTB 4 ), alongside its effects on the reduction of calcium oxalate (CaOx) crystals. Materials and methods The anti-urolithiatic activity of P. regnellii infusion was evaluated using urine containing calcium oxalate (CaOx) crystals at concentrations of 0.5, 1.0, and 1.5 mg/mL. The results were compared to negative and positive controls (sodium citrate and Cystone®). Anti-inflammatory activity was assessed using an ex vivo human whole blood assay, evaluating key inflammation mediators, prostaglandin E 2 (PGE 2 ) and leukotriene B 4 (LTB 4 ). The infusion’s chemical profile was determined by UHPLC-ESI-HRMS in positive ion mode, using a gradient chromatographic method. Data were processed using MZmine software, and chemical annotation was performed utilizing in-house and online databases. Results In the ex vivo anti-inflammatory assay, infusion samples significantly reduced LTB 4 and PGE 2 levels with significant statistical differences compared to the negative control ( p ≤0.05). The infusion demonstrated inhibition percentages of 57.4% and 75.1% for the release of LTB 4 and PGE 2 , respectively. In the in vitro anti-urolithiatic evaluation, all tested concentrations of P. regnellii showed statistically significant differences compared to the negative control ( p ≤0.05), with the highest concentration (1.5 mg/mL) demonstrating the strongest crystal reduction capacity (90.4%) and a calculated IC 50 value of 0.21 mg/mL for anti-urolithiatic activity. Metabolic profiling of the aqueous extract revealed the presence of multiple bioactive compounds. The predominant classes of annotated compounds found on P. regnellii infusion were flavonoids, and other classes of compounds were also found. From all detected metabolites, 12 could be annotated at level 2 of confidence. Conclusions This study provides scientific evidence supporting the traditional use of P. regnellii infusion related to inflammatory conditions. Additionally, the evaluation of its anti-urolithiatic effects expands the preliminary pharmacological insights into this species. Collectively, these findings suggest that P. regnellii may represent a promising source of bioactive compounds for the development of multitarget strategies addressing both inflammatory processes and urolithiasis-associated mechanisms.Daniele de Oliveira Silva; Lara P. D’ M. Costa; Paula P.O. Salem; Albert Katchborian-Neto; Paulo R.S. da Silva; Gabriel S. Viana; Jerônimo Schultz da Silva; Michael Murgu; Danielle F. Dias; RuAngelie Edrada‐Ebel; Daniela A. Chagas-Paula; Marisi G. Soares

Ex vivo; In vivo; Piper; Inflammation; Leukotriene B4; Prostaglandin E2; Urine; Prostaglandin E; Pharmacology; Chemistry; Oxalate; In vitro; Traditional medicine; Calcium; Anti-inflammatory

2026-06-30https://doi.org/10.1016/j.jep.2026.122142Journal of Ethnopharmacology 20261Demographic differences and distribution patterns of autoimmune diseases in a city in southeastern of Minas Gerais, BrazilThis study aims to describe the epidemiological profile of autoimmune diseases in residents of Juiz de Fora (Minas Gerais, Brazil), according to sex, age group, self-reported race, and affected body system. This cross-sectional study used secondary data from the Integrated Pharmaceutical Assistance Management System (SIGAF) including residents of Juiz de Fora diagnosed with autoimmune diseases between 2019 and 2023. Data on sex, age, self-reported race, diagnosis (ICD-10), dispensed medications, and affected body system were collected. Descriptive statistics and chi-square tests were performed, with a significance level set at 5%. A total of 2,229 patients were included, mostly women (n = 1520, 68.2%), white individuals (n = 1404, 63%), and those aged 45-59 years (n = 783, 35.1%). The most frequent diseases were rheumatoid arthritis (n = 827, 37.1%), type 1 diabetes mellitus (n = 387, 17.4%), and Crohn’s disease (n = 364, 16.3%). Musculoskeletal (n = 976, 43.8%) and digestive (n = 659, 29.6%) autoimmune diseases were the most prevalent, showing significant differences by sex, age, and self-reported race (p < 0.05). The most frequently dispensed medications were rapid-acting insulin analogs (n = 387, 17.4%), leflunomide (n = 379, 17.0%), azathioprine (n = 284, 12.7%), and mesalazine (n = 247, 11.1%). The study highlights the predominance of musculoskeletal and digestive autoimmune diseases among middle-aged adults, with higher occurrence in women and white individuals, emphasizing the need for targeted surveillance and health planning strategies for these groups.Vanderleia Soeli de Barros Zampier; Yuri de Lima Medeiros; Jacy Gameiro; Isabel Cristina Gonçalves Leite

Rheumatoid arthritis; Epidemiology; Diabetes mellitus; Autoimmune disease; Disease; Azathioprine; Medicine; Immunology; Public health; Obesity; Arthritis; Environmental health; Population; Demography

2026-06-08https://doi.org/10.11606/issn.1679-9836.v105i4e-242694Revista de Medicina 20261Soft Routing-Inspired Specialization for Efficient Satellite Image Time Series SegmentationPaulo Victor de Magalhães Rozatto; Saulo Moraes Villela; Luiz Maurílio da Silva Maciel; Marcelo Bernardes Vieira

Pipeline (software); Scalability; Segmentation; Inference; Flexibility (engineering); Image segmentation; Time series; Series (stratigraphy); Computer science; Artificial intelligence; Latency (audio); Satellite; Data mining; Real-time computing; Image processing; Image (mathematics); Computer vision

2026-06-30https://doi.org/10.1007/978-3-032-30488-9_3Lecture notes in computer science 20261International consensus on mesopancreas and total mesopancreas excision (MESODELPHI)Luís Felipe Leite; Marcos Belotto; Marcelo de Sá; Samuel Menezes; Luiz F. Almeida; Mohammad Abu Hilal; C. Alcázar; Juan Santiago Azagra; A. Balakrishnan; Frederik Berrevoet; Marc G. Besselink; Gerardo Blanco‐Fernández; Ugo Boggi; Óscar Chapa-Azuela; F.J.F. Coimbra; Bobby V.M. Dasari; S Dokmak; Álvaro A. Duarte; Massimo Falconi; Alexandre Ferreira Oliveira; Giuseppe Fusai; Isabella Frigerio; M Giménez; Benedetto Ielpo; Yosuke Inoue; Nicolás Jarufe; Enrique Jiménez Chavarría; Mickaël Lesurtel; Giuseppe Malleo; Giovanni Marchegiani; Oscar Mazza; Cássio Virgílio C. de Oliveira; N. O’Rourke; Sanjay Pandanaboyana; Elena Rangelova; Luís Sabater; Sohei Satoi; Alain Sauvanet; Mario Serradilla-Martín; Ajith K. Siriwardena; Ernesto Sparrelid; Patrick Starlinger; Stefan Stättner; Oliver Strobel; Christian Sturesson; Celia Villodre; Jens Werner; Paulo César Galvão do Amaral; Renata D’Alpino Peixoto; Pierre‐Alain Clavien; José Manuel Ramia

MEDLINE; Consensus conference; Medicine; General surgery; Surgery

2026-06-01https://doi.org/10.1016/j.hpb.2026.06.012HPB 20261Association Between Depressive Symptoms and Physiological Risk Factors for FallsObjectives: Objective: To investigate the association between depressive symptoms and falls in community-dwelling older adults. Methods: Methods: This is a cross-sectional study with 278 participants aged 60 or older. Information on clinical and sociodemographic data were obtained from a structured interview, depressive symptoms were assessed with the Geriatric Depression Scale (GDS), falls in the previous year were self-reported, and risk of falls was assessed with the Physiological Profile Assessment (PPA). Fallers and nonfallers were compared with Mann-Whitney and chi-squared tests. A binary logistic model was used to investigate the association between falls and GDS score, followed by a binomial negative regression model to analyze the association of GDS score and the number of falls. Finally, groups of individuals screened positive or negative for depression were compared for risk of falls and each individual's PPA test. Results: Discussion: Fallers presented more chronic conditions, polypharmacy, worse subjective health status and higher GDS scores. Individuals with higher GDS scores presented a higher chance of falling. The number of falls was not associated to the GDS score; however, there was an association between falls and the number of morbidities. Positive screening for depression was associated to a higher risk of falls according to the PPA, as well as to reaction time. Conclusion: Conclusion: Fallers presented more depressive symptoms, morbidities, polypharmacy, and worse subjective health status. Depressive symptoms do not act directly over the number of falls; nonetheless, those with depressive symptoms presented a higher chance of falling, which may be associated to slower reaction time. Psychological symptoms play an important role in falls, and should, therefore, be considered in identifying older people at risk and in developing prevention programs.Natalia Reynaldo Sampaio; Gabriela do Nascimento Cândido; Ully Aléxia Caproni Corrêa; Taís Gonçalves Soares; Sílvia Lanziotti Azevedo da Silva; Juscélio Pereira da Silva; Leani Souza Máximo Pereira; Daniele Sirineu Pereira

Geriatric Depression Scale; Depressive symptoms; Depression (economics); Association (psychology); Logistic regression; Injury prevention; Poison control; Suicide prevention; Medicine; Occupational safety and health; Human factors and ergonomics; Psychiatry; Cross-sectional study; Clinical psychology; Binomial regression

2026-01-01https://doi.org/10.1155/jare/2687374Journal of Aging Research 20261Early Improvement in Cardiac Autonomic Modulation After a Recreational Physical Training Program in Healthy ChildrenPhysical activity is known to influence cardiovascular regulation in children. However, evidence regarding cardiac autonomic responses to recreational physical training (RPT) in healthy pediatric populations remains limited. Thus, this study aimed to investigate changes in cardiac autonomic modulation associated with a RPT program in healthy children. We conducted a quasi-experimental pre-post intervention study including healthy children who participated in a 10-week RPT. Cardiac autonomic modulation was assessed at rest using short-term heart rate variability (HRV) analysis. HRV measurements (time- and frequency-domain), anthropometric, hemodynamic, and cardiorespiratory variables were evaluated before and after the intervention. Effect sizes were calculated to estimate the magnitude of observed changes. Seventy-four participants (31 girls and 43 boys; mean age 8.6 ± 0.9 years) were included. Following the intervention, significant increases were observed in time-domain HRV measurements, including SDNN (standard deviation of normal RR intervals; pre- 49.1 ± 2.1, post- 61.9 ± 2.1 ms; p < 0.01) and RMSSD (root mean square of successive differences between normal RR intervals; pre- 52.1 ± 2.7, post- 65.2 ± 2.7 ms; p < 0.01), with large effect sizes. No significant changes were detected in blood pressure, estimated peak oxygen uptake, or frequency-domain HRV. Waist circumference decreased (pre- 66.2 ± 2.0, post- 65.2 ± 2.0 cm; p < 0.01), whereas body mass index percentile remained unchanged. Therefore, participation in a RPT was associated with favorable changes in cardiac autonomic modulation in healthy children, particularly in measurements reflecting global variability and parasympathetic activity. These findings suggest that RPT may elicit early autonomic adaptations during childhood, even in the absence of measurable changes in traditional cardiovascular risk markers.Lívia Victorino de Souza; Maria Eduarda De Araujo Almeida Muniz; Danilo Rufino Cavalcante de Souza; Franciele De Meneck; Roberta da Silva Teixeira; Évelim Leal de Freitas Dantas Gomes; Leonardo Barbosa de Almeida; Paula Silva de Carvalho Chagas; Maria do Carmo Franco

Cardiorespiratory fitness; Heart rate variability; Waist; Percentile; Heart rate; Autonomic nervous system; Body mass index; Cardiac surgery; Medicine; Physical therapy; Cardiology; Internal medicine; Physical medicine and rehabilitation; VO2 max; Exercise physiology; Physical activity; Vagal tone; Physical exercise; Electrocardiography

2026-06-30https://doi.org/10.1007/s00246-026-04357-2Pediatric Cardiology 20261Finite element analysis of the stress distribution in posterior zirconia implants: a systematic reviewOBJECTIVES: The aim of this systematic review was to assess the stress distribution of zirconia implants compared to titanium implants using finite element analysis (FEA). The main research question was whether zirconia demonstrate mechanical behavior comparable to or better than titanium in posterior applications. MATERIALS AND METHODS: This study was previously registered in PROSPERO (CRD42023480344). Six electronic databases (Web of Science, PubMed, Scopus, Capes Journals, Lilacs, and Scielo) were searched up to March 2024. The terms "finite element analysis," "posterior*," "jaw," and "zirconia implant" were used. The inclusion criteria were in silico finite element studies comparing zirconia and titanium implants in the posterior jaws, exclusion criteria were non-English, non-finite element, anterior region, or studies without zirconia-only groups. Five evaluators independently conducted assessments using predefined criteria in Rayyan©. The risk of bias was assessed by ROBFEAD. Titles and abstracts were screened, and studies meeting the criteria underwent full-text assessment. RESULTS: The search retrieved 512 studies, with 368 remaining after duplicate removal. Seven studies met the inclusion criteria, its reference lists were also screened. Zirconia implants showed mechanical strength equal to or greater than titanium implants. Implant geometry and abutment diameter influenced stress distribution on the peri-implant bone, implant, and abutment. Bioglass-zirconia implants demonstrated superior performance compared to conventional zirconia. Root-like implant geometries and thread designs were advantageous in posterior regions. A limitation of finite element studies is the variability in evaluation criteria, modeling parameters, material properties, loading conditions, and group configurations, as well as simplifications in geometry and boundary conditions, which may impact the comparability and clinical relevance of the results. CONCLUSIONS: Zirconia implants offer potential for stress modulation and are viable in posterior areas. However, properties vary based on geometry, thread, and abutment design compared to titanium. CLINICAL RELEVANCE: Understanding the biomechanical behavior of zirconia implants can improve clinical outcomes in dental implantology, emphasizing the need for further research. This review received no external funding.Rafaela Passos de Souza; Lorena Aparecida Nery Araújo; Marcelo Tarcísio Martins; Raylla Jennifer Silva de Souza; Thaís Izidoro Pires; Fabíola Pessôa Pereira Leite; Sheila Butler

Finite element method; Stress (linguistics); Cubic zirconia; Distribution (mathematics); Oral and maxillofacial surgery; Medicine; Orthodontics; Composite material

2026-06-30https://doi.org/10.1186/s12903-026-09039-2BMC Oral Health 20261Predicting Temporal Metrics in Dynamic Systems Using Machine LearningEduardo S. O. Marques; Saulo Moraes Villela; Heder S. Bernardino; Alex Borges Vieira

Centrality; Multilayer perceptron; Time series; Representation (politics); Identification (biology); Artificial neural network; Computation; Convolutional neural network; Perceptron; Computer science; Machine learning; Artificial intelligence; Data mining; Series (stratigraphy); Predictive modelling; Feature (linguistics)

2026-06-30https://doi.org/10.1007/978-3-032-30488-9_9Lecture notes in computer science 20261Openwater swimming research This bibliometric review examines the scientific literature on open water swimming, aiming to identify key themes and research trends up to December 2024. A comprehensive search was conducted across several databases, including SciELO, PubMed, Scopus, and Web of Science, using descriptors such as athletes , swimming , open water , marathon swimming , and ultra-distance . The review focused on full-text articles published in English, specifically analysing studies involving athletes competing in official 5, 10 and 25 km race distances at world championships and the Olympic Games, while excluding research on poolbased swimming, triathlon, and literature reviews. The analysis reveals a predominance of quantitative, observational studies, with a clear emphasis on performance monitoring and pacing strategies. These studies predominantly involve elite athletes (concentrated in the early-to-mid-twenties age range). Within the studies included in this review, topics such as hypothermia and probiotics appeared less frequently, possibly reflecting the challenges of conducting experimental studies in real open-water settings. Despite the growing popularity of open water swimming, as evidenced by the increasing number of registered competitions, research has been disproportionately focused on elite athletes, leaving a gap in the understanding of amateur participation. This review highlights critical gaps in research, particularly in the areas of sports psychology, physiology, biomechanics, nutrition, and safety of athletes. Among the studies conducted in real-world open-water settings included in this review, the limited number of experimental investigations presents an opportunity for future research to develop interventions aimed at enhancing both performance and safety while addressing the diverse needs of swimmers across competitive levels.Renato M. Ferreira; Géssyca T. de Oliveira; Everton R. Soares

Popularity; Amateur; Open water; Athletes; Grey literature; Psychological intervention; Observational study; Web of science; Bibliometrics; Elite; Elite athletes; Systematic review; Scopus; Geography; Critical appraisal; Political science; Scientific literature; Race (biology)

2026-01-01https://doi.org/10.26582/k.58.1.9Kinesiology 20261Anthropometric and biomechanical predictors of competitive success in a Brazilian regional taekwondo competitionIntroduction: Previous research indicated that both anthropometric characteristics and vertical jump biomechanics impacted taekwondo performance. However, there were currently no predictive models for athletic success based on anthropometric characteristics or physical performance in the vertical jump. Objective: The aim of this study was to analyze how anthropometric characteristics and physical performance in the drop jump could predict the athletic success of competitive taekwondo athletes at a regional level. Methodology: A total of 46 athletes (28 male, 18 female) were categorized as regional champions or non-regional champions based on regional competition placement. Lower limb anthropometry and drop jump performance (30-cm height) on force plates were assessed. Bivariate logistic regressions determined the predictive power of these variables Results: The champions showed significantly greater absolute and relative thigh length and a lower crural index compared to non-regional champions. Regional champions outperformed non-regional champions in most force and power production variables in drop jump performance. Logistic regression models identified normalized thigh length (AOR = 2.07; p = 0.003) and normalized average propulsive power (AOR = 1.38; p = 0.002) as the most robust predictors of athletic success. The latter variable exhibited the highest discriminatory power (AUC = 0.83). Conclusions: It was demonstrated that both anthropometric characteristics and power output during drop jump performance serve as valid predictors of performance in regional taekwondo athletes. The results highlighted the importance of power output and establish the drop jump as a practical tool for talent identification and training optimization.Felipe Inostroza-Ríos; Sebastián Sepúlveda-González; Mateus Henrique Santos; N. Almeida; Keveenrick Ferreira Costa; Esteban Aedo-Muñoz; Lúcio Marques Vieira Souza; Jorge Pérez-Contreras; Ciro José Brito

Anthropometry; Jump; Logistic regression; Athletes; Vertical jump; Bivariate analysis; Variables; Regression analysis; Stretch shortening cycle; Physical therapy; Statistics; Physical medicine and rehabilitation; Mathematics; Long jump; Biomechanics; Competitive athletes; Econometrics; Competition (biology); Predictive modelling

2026-05-16https://doi.org/10.47197/retos.v82.119367Retos 20261Trabalho rural e sobrecarga muscularIntroduction: This article analyzes the granting of breaks during the workday for rural workers as an important measure to prevent fatigue and avoid illness, in the context of work involving muscle overload. It discusses the relevance of the Repetitive Appeal Incident (IRR) 245 of the Superior Labor Court (TST), which highlights the right to breaks for rural workers who perform activities standing or with muscle overload. Objetive: To reflect on the employer's responsibility to guarantee a safe work environment and implement preventive measures to avoid occupational diseases. The aim is to highlight the interface between law, health, and ergonomics, based on the application of NR-31 MTE (Brazilian Regulatory Standard 31 of the Ministry of Labor and Employment) focusing on the analogical consideration of article 72 of the CLT (Brazilian Labor Code), which provides for ten-minute breaks every ninety hours for typing activities for rural workers. Methodology: A qualitative methodology is adopted, focusing on a literature review of the concepts in question, as well as doctrinal analysis for transdisciplinary immersion, involving Law and Physiotherapy. A review of labor law case law on the problem at hand and an analysis of data on rural workers' absences are presented. Results: In the context of rural work, a relationship is observed between muscle overload, fatigue, and illnesses such as RSI/WRULD. Granting breaks during the workday represents a preventive measure against occupational diseases, in addition to reducing fatigue and bringing well-being to workers. Conclusion: The assertion strengthens a transdisciplinary dialogue between law and physiotherapy, fostering an integrated framework that brings to the forefront a healthy work environment and the mitigation of environmental risks, while positioning ergonomics as a foundation for well-being, efficiency, and social protection for workers KEYWORDS: breaks; ergonomics; fatigue; physiotherapy; rural work.Alexandre Pimenta Batista Pereira; Peterson Marco de Oliveira Andrade

Context (archaeology); Appeal; Assertion; Work (physics); Relevance (law); Christian ministry; Labour law; Sociology; Business; Occupational safety and health; Political science; Law; Rural area; Public relations

2026-06-22https://doi.org/10.33239/rjtdh.v9.325Revista Jurídica Trabalho e Desenvolvimento Humano 20261Self‐Determined Motivation and Physical Activity in Chronic Obstructive Pulmonary DiseaseABSTRACT Background Chronic Obstructive Pulmonary Disease (COPD) is associated with reduced physical activity, negatively affecting prognosis and quality of life. According to Self‐Determination Theory (SDT), the quality of motivation plays a key role in sustaining active behavior, but evidence in COPD remains limited. Objective The objective of this study was to examine the associations between different types of exercise motivation and objectively measured physical activity and sedentary behavior in individuals with COPD. Methods This cross‐sectional study included 50 community‐dwelling individuals with COPD (GOLD stages 2–3; mean age 69.4 ± 7 years). Motivation was assessed using the Behavioral Regulation in Exercise Questionnaire (BREQ‐3) and the Self‐Determination Index (SDI). Physical activity was objectively measured with the ActiGraph GT3X accelerometer. Associations were examined using Spearman's correlations and hierarchical multiple linear regression models. Results Integrated regulation was positively correlated with light physical activity (rho = 0.43, p < 0.05), total physical activity (rho = 0.40, p < 0.05), and daily step count (rho = 0.43, p < 0.05). Intrinsic motivation was positively correlated with light physical activity (rho = 0.37, p < 0.05), total physical activity (rho = 0.37, p < 0.05), and daily step count (rho = 0.35, p < 0.05). The Self‐Determination Index was positively associated with light physical activity (rho = 0.28, p < 0.05) and daily step count (rho = 0.33, p < 0.05), but showed no significant association with sedentary time. In hierarchical regression analyses, higher levels of integrated regulation were independently associated with higher daily step count, with each one‐unit increase associated with 687 additional steps per day. For total physical activity, integrated regulation showed a borderline independent association with the outcome after adjustment for clinical covariates (β = 0.279, p = 0.054), whereas FEV 1 (% predicted) remained independently associated with total physical activity (β = 0.304, p = 0.027). For sedentary behavior, higher self‐determination was independently associated with lower sedentary time; specifically, each one‐unit increase in the Self‐Determination Index corresponded to approximately 13 fewer sedentary minutes per day (β = −0.327, p = 0.026). Conclusion Self‐determined motivation was associated with more favorable physical activity profiles in individuals with COPD. Integrated regulation was independently associated with daily step count, while higher self‐determination was associated with lower sedentary time. These findings suggest that autonomous forms of motivation may be important factors to consider when promoting active lifestyles in people with COPD.Larissa Guimarães Paiva; Nara Batista de Souza; Vitória Lourdes de Oliveira Lima; Vitória Lourdes de Oliveira Lima; Manuela Karloh; J dos Santos; Cristino Carneiro Oliveira; Klaus Chaves Alberto; Daniela Pereira dos Reis de Almeida; Anderson José; Carla Malaguti

Physical activity; COPD; Pulmonary disease; Sedentary behavior; Regression analysis; Metabolic equivalent; Linear regression; Physical exercise; Medicine; Physical therapy; Physical activity level; Multilevel model; Sedentary lifestyle; Internal medicine; Quality of life (healthcare); Disease

2026-06-30https://doi.org/10.1111/crj.70209The Clinical Respiratory Journal 20261NEUTRAL NETWORKS — FROM AMERICAN HABITS TO BRAZILIAN PREFERENCEThis article examines the concept of neutral networks as open-access, wholesale-only telecommunications infrastructure models, based exclusively on the provided academic references. Drawing on technical and economic literature, the study analyzes how structural separation between infrastructure ownership and retail service provision may reduce physical network duplication, intensify service-layer competition, and shape investment incentives. The analysis compares market trajectories in the United States and Brazil, highlighting how the adoption of neutral network models depends on market structure, platform rivalry, ISP fragmentation, and broadband policy design. International empirical evidence suggests that the impact of open-access arrangements on fiber penetration and investment varies according to regulatory calibration and competitive architecture, indicating that neutral networks are not a universal solution but a context-dependent institutional instrument. The findings emphasize that the effectiveness of wholesale open-access models requires robust governance, carefully designed wholesale pricing mechanisms, and alignment between network engineering parameters and economic incentives.Claudio Aguiar

Investment (military); Broadband; Preference; Empirical evidence; Market penetration; Empirical research; Industrial organization; Business; Economics; Microeconomics; Broadband networks; Telecommunications; Public economics; Marketing; Nonlinear pricing; Service (business)

2026-06-30https://doi.org/10.56238/rcsv12n2-006Revista Sistemática 20261A programação orientada à gambiarra (POG)Este artigo investiga e propõe a programação orientada à gambiarra (POG) como um paradigma pedagógico insurgente para a educação tecnológica nas artes. Em oposição aos modelos hegemônicos baseados em eficiência, usabilidade e acabamento, a POG eleva a precariedade, o improviso, o erro, a subversão e o inacabado à condição de operadores epistemológicos. O artigo articula a fundamentação teórica do paradigma — dialogando criticamente com os fundamentos da computação — e apresenta sua proposta operacional, sistematizada em um ecossistema de ferramentas e uma cartografia pedagógica aplicada. A POG se afirma, assim, como um gesto de resistência ao tecnofeudalismo algorítmico, ao colonialismo de dados e à plataformização da educação, reconfigurando o letramento digital como uma prática crítica que devolve à educação tecnológica seu caráter emancipador.Henrique Vaz

Context (archaeology); Order (exchange); Period (music); Conjunction (astronomy); Term (time); Philosophy

2026-06-24https://doi.org/10.22409/gambiarra.v7i8.69484Gambiarra 20261Responsible AI at the Edge: an Architecture Based on Federated Learning to Protect Sensitive Data in Continuous Health MonitoringLuiz Gustavo Nazareth; Gabriel Silva; Rubia Viol; Victor Ströele; Regina Braga; Azzedine Boukerchea

Federated learning; Personalization; Architecture; Information privacy; Big data; Enhanced Data Rates for GSM Evolution; Deep learning; Masking (illustration); Computer science; Artificial intelligence; Mobile device; Data modeling

2026-01-01https://doi.org/10.1007/978-3-032-23260-1_27Lecture notes on data engineering and communications technologies 20261Simulação Computacional do Deslocamento de Espuma Considerando a Adsorção de Surfactante em Meios Porosos HeterogêneosEste trabalho apresenta uma investigação numérica sobre o deslocamento de espuma em meios porosos heterogêneos, considerando os efeitos de adsorção de surfactante sob as abordagens em equilíbrio e cinética. O uso de surfactante para a geração de espuma reduz a mobilidade do gás frente a fase aquosa diminuindo os efeitos de \textit{fingering} viscoso e aumentando a eficiência de varredura do gás no meio poroso. Este problema é modelado pelo acoplamento da lei de Darcy e as equações de conservação de massa para as fases água e gás, juntamente com uma equação de transporte para o surfactante dissolvido. A solução numérica é obtida por meio de um algoritmo sequencial que combina um método de elementos finitos mistos híbridos, aplicado à hidrodinâmica, e um esquema de volumes finitos \textit{central-upwind} de alta ordem para o problema de transporte. As simulações avaliam as técnicas de coinjeção e injeção alternada de gás e surfactante (SAG), mostrando que o fenômeno de adsorção reduz a disponibilidade de surfactante na fase aquosa, limita a formação de espuma e diminui a eficiência de varredura do gás. Comparativamente, a estratégia SAG apresentou melhor desempenho quando comparada a coinjeção, devido à maior percolação do surfactante e consequente aumento da viscosidade aparente do gás com espuma. Os resultados confirmam que a adsorção de surfactante é um fator crítico na modelagem e na viabilidade de processos de recuperação avançada de petróleo assistidos por espuma.Filipe F. de Paula; Iury Igreja; Grigori Chapiro

Qualitative analysis; First order; Order (exchange); Humanities

2026-06-03https://doi.org/10.5540/tcam.2026.027.e01893Trends in Computational and Applied Mathematics 20261Adaptive Weighted Moving Average to Improve Availability in LoRa-Based IoT NetworksKhalid Usman; Afaq Inayat; A Araujo de Oliveira; Edelberto Franco Silva

Internet of Things; Moving average; Feature (linguistics); Field (mathematics); Key (lock); Computer science; Real-time computing; Artificial intelligence

2026-01-01https://doi.org/10.1007/978-3-032-23271-7_32Lecture notes on data engineering and communications technologies 20261Contos de Fadas e Textos FactuaisThis study investigates, through intertextual analysis (Kristeva, 1980), the relationships between fairy tales and factual texts, based on the hypothesis that these narrative genres display discursive correspondences and shifts. For the purposes of this study, factual texts are understood as texts that convey verified information published by established media outlets. The study aims to demonstrate the underexplored pedagogical value of fairy tales and to propose their reinterpretation in contemporary educational, family, and leisure contexts as critical tools for combating misinformation. It examines how fictional and factual narratives address sensitive social, philosophical, and educational issues, emphasizing their role in developing critical readers in a context marked by transmedia practices, the digital circulation of content, and the global growth of misinformation.Fernanda Sevarolli Creston Faria Kistemann; Marco Aurélio Reis

Reinterpretation; Narrative; Context (archaeology); Value (mathematics); Sociology; Art; Humanities; Literature; History

2026-06-23https://doi.org/10.36311/1981-1640.2026.v20.e026023Brazilian Journal of Information Science research trends 20261Evaluation of anticoagulation quality in patients with primary antiphospholipid syndrome at a tertiary hospitalOBJECTIVE: This study aimed to evaluate the quality of anticoagulation control in patients with primary antiphospholipid syndrome, using time in therapeutic range. Secondary objectives included identifying factors associated with poor anticoagulation control. METHODS: Anticoagulation quality was assessed in a retrospective study including patients with primary Antiphospholipid Syndrome. Time in therapeutic range was calculated using the Rosendaal method for patients with at least four international normalized ratio measurements in 2019. Statistical comparisons were performed between patients with time in therapeutic range ≥60% and those with lower or incalculable time in therapeutic range. RESULTS: A total of 93 patients were included, of whom 43 (46.2%) had a calculable time in therapeutic range. Among these, 32 patients (74.4 achieved time in therapeutic range ≥60%, with a median time in therapeutic range of 89.3%. However, 61 patients (65.6%) had insufficient follow-up, resulting in an incalculable time in therapeutic range. No significant differences were observed between patients with good and poor anticoagulation control regarding demographic or clinical variables. During the follow-up period, three thrombotic events (3.4%) and two major bleeding events (2.3%) were recorded. CONCLUSION: Our findings indicates that only 34.4% of patients with primary antiphospholipid syndrome achieved adequate anticoagulation control and inadequate follow-up remains a major barrier. Further studies are needed to identify factors contributing to suboptimal time in therapeutic range and to improve anticoagulation management in this high-risk population.Renata P Mello; Maria Eugenia Teixeira Bicalho; Gustavo Guimarães Moreira Balbi; Flávio Signorelli; Danieli Andrade

Quality (philosophy); Antiphospholipid syndrome; Primary care; Thrombosis; MEDLINE; Disease; Medicine; Intensive care medicine; Emergency medicine; Pediatrics; Medical emergency

2026-01-01https://doi.org/10.31744/einstein_journal/2026ao1668Einstein (São Paulo) 20261FIGURE 5 in On the type series of Lacerta teguixin Linnaeus, 1758 (Squamata: Teiidae)FIGURE 5. Description of Lacerta teguixin in the catalogue of Museum Adolphi Friderici (Linnaeus 1754, p. 45). The Latin (left) and Swedish (right) texts are equal and can be translated as: Teguixin. Lizard with a long, tapering tail, pentadactyl limbs, without crest and with folded sides. Amoen. Acad. 1. p. 128. Syst. nat. 36. n. 19. The lizard Teguixin or the other Tejuguacu. Seb. thes. 1. p. 150. t. 96. f. 1.Henrique C. Costa; Wolfgang Denzer

Tapering; Series (stratigraphy); Type (biology); Lizard; Crest; Mathematics; Geometry

2026-05-15https://doi.org/10.5281/zenodo.21178295Zenodo (CERN European Organization for Nuclear Research) 20261FIGURE. 9 in On the type series of Lacerta teguixin Linnaeus, 1758 (Squamata: Teiidae)FIGURE. 9. Lectotype of Lacerta teguixin (UPSZTY 13) photographed in 2025, desiccated. Credits: Hans Mejlon, curator at the Museum of Evolution, Uppsala University, Sweden.Henrique C. Costa; Wolfgang Denzer

Series (stratigraphy); Type (biology); Mathematics

2026-05-15https://doi.org/10.5281/zenodo.21178305Zenodo (CERN European Organization for Nuclear Research) 20261FIGURE 4 in On the type series of Lacerta teguixin Linnaeus, 1758 (Squamata: Teiidae)FIGURE 4. Description of Lacerta teguixin in Amphibia Gyllenborgiana (Linnaeus 1749b, p. 128–129). It can be translated as (from Lavila 2026): 14. LACERTA. Lizard with tapering tail, twice longer than the body, pentadactyl limbs, without crest and with folded sides. Lacerta Teguixin or Tejuguacu altera. Seb. thesaur. l. p. 150; tab. 96, Fig. 1. Head oblong, acuminate, depressed, slightly convex above and marked with various sutures; behind the frontal plate are two additional small plates, then a larger one plate in the middle, with four smaller ones above the eyes on each side, followed by two oblong ones and finally three angular scales. Thus, the head is almost serpent-like. The skin beneath the neck is loose and adorned with black spots that are darker than those on the rest of the body. Trunk covered with numerous circular striae, moniliform or filiform and articulated. On each side, from the head to the hind legs, there are numerous blunt, beaded folds. Tail with approximately 200 segments, which alternate dorsally. Unlike the previous lizard, the tail is not crossed but acuminate and one and a half times longer than the body. Forelimbs with five fingers, with 1 and 5 being subequal in length, 2 being longer, and 3 and 4 being almost equal and slightly longer than the second. Hind limbs also with five digits, with the internal toe being minute, 2 being longer than 3, 4 being the longest, and 5 hardly longer than the first and set apart from the others by some distance. Claws very sharp and moderately curved. Color entirely off-white with a slight tinge of cerulean, and there are dark gray bands present. Oval spots are scattered over the back (though less so in the tail) and the outer parts of the femora. Therefore, this lizard differs little from the previous one; however, it is a distinct species.Henrique C. Costa; Wolfgang Denzer

Tapering; Crest; Trunk; Head (geology); Claw; Dorsum; Series (stratigraphy); Anatomy; Mathematics; Geometry; Rest (music); Physics

2026-05-15https://doi.org/10.5281/zenodo.21178293Zenodo (CERN European Organization for Nuclear Research) 20261FIGURE 2 in On the type series of Lacerta teguixin Linnaeus, 1758 (Squamata: Teiidae)FIGURE 2. Description of Lacerta teguixin in Seba (1734: p. 150–151). Latin and French texts are not equal and can be translated as: LATIN SECTION No. 1. Tecuixin lizard, smaller, or Teiuguacu, from New Spain. The scales of the skin are deeply imbued with a saturated cerulean hue, variegated above with the palest bluish-white and white, especially upon the head, thighs, and feet. The tail, even unto its extremity, is wholly adorned with ribbon-like bands. No. 2. Another Tecuixin lizard, or Teiuguacu. In color this one indeed agrees with the former smaller one, yet in its marvelous ornamentation and variegation, here wrought by Nature, it surpassed the other. Let the mind, astonished, marvel at this inimitable ornament, and among created things so varied in color and disposition, behold and adore the omnipotent Creator. FRENCH SECTION No. 1. Small lizard named Tecuixin, or Teiuguacu, from New Spain. The scales which cover its skin are of a turquoise blue, mingled with white and an extremely pale blue, principally upon the head, thighs, and feet. Its tail is entirely adorned with bands fashioned like ribbons. No. 2. Another Tecuixin or Teiuguacu lizard, larger. Its color is the same as that of the preceding one, yet it surpasses it in the admirable variety of markings with which Nature has embellished it. One cannot contemplate this inimitable ornament, so varied among different animals, without being struck with astonishment, and without rising unto a profound adoration of the First Cause of all things.Henrique C. Costa; Wolfgang Denzer

Adoration; Section (typography); Variety (cybernetics); White (mutation); Character (mathematics); Type (biology); Behold; Art; Geology; Art history; Paleontology; Lizard; Stack (abstract data type)

2026-05-15https://doi.org/10.5281/zenodo.21178290Zenodo (CERN European Organization for Nuclear Research) 20261FIGURE 4 in On the type series of Lacerta teguixin Linnaeus, 1758 (Squamata: Teiidae)FIGURE 4. Description of Lacerta teguixin in Amphibia Gyllenborgiana (Linnaeus 1749b, p. 128–129). It can be translated as (from Lavila 2026): 14. LACERTA. Lizard with tapering tail, twice longer than the body, pentadactyl limbs, without crest and with folded sides. Lacerta Teguixin or Tejuguacu altera. Seb. thesaur. l. p. 150; tab. 96, Fig. 1. Head oblong, acuminate, depressed, slightly convex above and marked with various sutures; behind the frontal plate are two additional small plates, then a larger one plate in the middle, with four smaller ones above the eyes on each side, followed by two oblong ones and finally three angular scales. Thus, the head is almost serpent-like. The skin beneath the neck is loose and adorned with black spots that are darker than those on the rest of the body. Trunk covered with numerous circular striae, moniliform or filiform and articulated. On each side, from the head to the hind legs, there are numerous blunt, beaded folds. Tail with approximately 200 segments, which alternate dorsally. Unlike the previous lizard, the tail is not crossed but acuminate and one and a half times longer than the body. Forelimbs with five fingers, with 1 and 5 being subequal in length, 2 being longer, and 3 and 4 being almost equal and slightly longer than the second. Hind limbs also with five digits, with the internal toe being minute, 2 being longer than 3, 4 being the longest, and 5 hardly longer than the first and set apart from the others by some distance. Claws very sharp and moderately curved. Color entirely off-white with a slight tinge of cerulean, and there are dark gray bands present. Oval spots are scattered over the back (though less so in the tail) and the outer parts of the femora. Therefore, this lizard differs little from the previous one; however, it is a distinct species.Henrique C. Costa; Wolfgang Denzer

Tapering; Crest; Trunk; Head (geology); Claw; Dorsum; Series (stratigraphy); Anatomy; Mathematics; Geometry; Rest (music); Physics

2026-05-15https://doi.org/10.5281/zenodo.21178294Zenodo (CERN European Organization for Nuclear Research) 20261FIGURE 5 in On the type series of Lacerta teguixin Linnaeus, 1758 (Squamata: Teiidae)FIGURE 5. Description of Lacerta teguixin in the catalogue of Museum Adolphi Friderici (Linnaeus 1754, p. 45). The Latin (left) and Swedish (right) texts are equal and can be translated as: Teguixin. Lizard with a long, tapering tail, pentadactyl limbs, without crest and with folded sides. Amoen. Acad. 1. p. 128. Syst. nat. 36. n. 19. The lizard Teguixin or the other Tejuguacu. Seb. thes. 1. p. 150. t. 96. f. 1.Henrique C. Costa; Wolfgang Denzer

Tapering; Series (stratigraphy); Type (biology); Lizard; Crest; Mathematics; Geometry

2026-05-15https://doi.org/10.5281/zenodo.21178296Zenodo (CERN European Organization for Nuclear Research) 20261FIGURE. 10 in On the type series of Lacerta teguixin Linnaeus, 1758 (Squamata: Teiidae)FIGURE. 10. Stuffed specimen of Tupinambis teguixin (UPSZTY 72), labeled as "Lacerta orbicularis". This is not part of the type series of Lacerta teguixin. Credits: Hans Mejlon, curator at the Museum of Evolution, Uppsala University, Sweden.Henrique C. Costa; Wolfgang Denzer

Series (stratigraphy); Type (biology); Body type; Holotype; Mathematics

2026-05-15https://doi.org/10.5281/zenodo.21178308Zenodo (CERN European Organization for Nuclear Research) 20261Developing the pedagogical competencies of medical residency educators: Abem’s social accountabilityABSTRACT Introduction: Developing pedagogical competencies of health professional’s educators is complex and requires continuous evaluation to ensure effectiveness and sustainability. Objective: To describe a national postgraduate course model in pedagogical competencies, to characterize the sociodemographic and educational profile of participants involved in medical residency programs, and to analyze changes in self-reported pedagogical competencies before and after course completion. Methods: This cross-sectional study included faculty and preceptors selected through a national public call, comprising three cohorts of a postgraduate course, with 45 places distributed across nine regional divisions of the Brazilian Association of Medical Education. Eligible participants were actively involved in medical residency programs. All participants completed baseline questionnaires addressing sociodemographic characteristics and professional background. Participants from the first cohort that had completed the course additionally performed self-assessment of pedagogical competencies in four domains: role as educator, relationship with learners, teamwork, and assessment systems. These evaluations were conducted before and between one and six months after course completion. Comparisons were performed using the Wilcoxon signed-rank test. Results: Of 261 selected candidates, 97 (71.85%) filled the 135 available places, representing all regions of the country. Among these, 62 (63.91%) were involved in medical residency programs, predominantly physicians (74.22%). Regarding institutional affiliation, 29.03% worked exclusively in public institutions and 19.35% exclusively in private institutions. In terms of academic qualifications, 29.03% held a doctoral degree and 40.32% a master’s degree. Half of the participants had more than 20 years of experience in preceptorship. In the first completed cohort (n=30), self-assessment demonstrated significant improvements across all pedagogical competency domains (p < 0.001). Conclusion: The proposed training model proved feasible, with low dropout rates and promotion of geographical equity at a national level, despite some unfilled places. The observed improvement in self-reported pedagogical competencies suggests a meaningful contribution to enhancing the quality of medical residency training and education.Denise Herdy Afonso; Lia Márcia Cruz da Silveira; Maria Helena Senger; Sandro Schreiber de Oliveira; Oscarina da Silva Ezequiel; Rodrigo Pinheiro Silveira; Aristides Augusto [UNESP] Palhares Neto; Rosiane Viana Zuza Diniz

Cohort; Accountability; Educational measurement; Public health; Baseline (sea); Medical school; Medical education; Psychology; Medicine; Higher education; Cohort study

2026-01-01https://doi.org/10.1590/1981-5271v50.supl.1-20260158.ingRevista Brasileira de Educação Médica 20261FIGURE 1 in On the type series of Lacerta teguixin Linnaeus, 1758 (Squamata: Teiidae)FIGURE 1. Description of Lacerta teguixin in the 10th edition of Systema Naturae (Linnaeus 1758, p. 208). The Latin text can be translated as: Teguixin. 36. Lizard with a cylindrical, long tail; a lateral folded suture. [Amen. acad. 1. p. 128]. Lizard with a cylindrical, long tail, five-toed feet, no crest, abdominal lateral folds. [Mus. Ad. Fr. 1. p. 45; Seb. mus. 1. t. 96. f. 1]. Lives in the Indies. Neck with triple fold below.Henrique C. Costa; Wolfgang Denzer

Lizard; Series (stratigraphy); Type (biology); Domain (mathematical analysis); Mathematics; Anatomy; Geometry

2026-05-15https://doi.org/10.5281/zenodo.21178288Zenodo (CERN European Organization for Nuclear Research) 20261FIGURE. 8 in On the type series of Lacerta teguixin Linnaeus, 1758 (Squamata: Teiidae)FIGURE. 8. Lectotype of Lacerta teguixin (UPSZTY 13) photographed in the 1990's. Credits: Marinus S. Hoogmoed.Henrique C. Costa; Wolfgang Denzer

Series (stratigraphy); Type (biology); Body type; Mathematics

2026-05-15https://doi.org/10.5281/zenodo.21178301Zenodo (CERN European Organization for Nuclear Research) 20261FIGURE 6 in On the type series of Lacerta teguixin Linnaeus, 1758 (Squamata: Teiidae)FIGURE 6. Description of [Lacerta] Teguixin (No. 19) in the sixth edition of Systema Naturae. Left: the Stockholm edition (Linnaeus 1748a, p. 36); right: the Leipzig edition (Linnaeus 1748b, p. 36). The text can be translated as: 19. Lizard with a long, tapering tail, pentadactyl limbs, without crest and with folded sides.Henrique C. Costa; Wolfgang Denzer

Tapering; Series (stratigraphy); Type (biology); Crest; Mathematics; Geometry

2026-05-15https://doi.org/10.5281/zenodo.21178298Zenodo (CERN European Organization for Nuclear Research) 20261FIGURE. 7 in On the type series of Lacerta teguixin Linnaeus, 1758 (Squamata: Teiidae)FIGURE. 7. Label on the original Linnaeus jar for Lacerta teguixin, written by Carl Peter Thunberg, his student. Below the species name, it reads "Mus. Gyllenb.", meaning that the specimen comes from the Gyllenborg donation. Credits: Hans Mejlon, curator at the Museum of Evolution, Uppsala University, Sweden.Henrique C. Costa; Wolfgang Denzer

Series (stratigraphy); Type (biology); Meaning (existential); Holotype; Mathematics; Biology

2026-05-15https://doi.org/10.5281/zenodo.21178299Zenodo (CERN European Organization for Nuclear Research) 20261Desenvolvimento de competências pedagógicas de educadores com atuação na residência médica: responsabilidade social da AbemRESUMO Introdução: O desenvolvimento de competências pedagógicas na formação dos profissionais de saúde e educadores é desafiador, necessitando ser continuamente analisado. Objetivo: Descrever um modelo de formação em competências pedagógicas, caracterizando o perfil sociodemográfico e formativo dos participantes que atuam na residência médica (RM), e analisar mudanças nas autoavaliações referidas sobre suas competências pedagógicas, antes e depois do curso. Método: Trata-se de um estudo transversal que envolve docentes/preceptores selecionados em edital público, compondo três turmas do curso, até o momento, com vagas distribuídas nas nove regionais da Abem. Somente profissionais atuantes em programas de RM foram incluídos nesta pesquisa. Todos responderam a questionários relacionados ao perfil sociodemográfico e à formação profissional. Somente a primeira turma, já finalizada, realizou a autoavaliação sobre competências pedagógicas nas seguintes ênfases: como educador, na relação com o educando, no trabalho em grupo e no sistema de avaliação, antes e após um a seis meses do término do curso, comparadas pelo teste de Wilcoxon. Resultado: Dos 261 selecionados, 97 (71,85%), distribuídos por todas as regiões do país, ocuparam as 135 vagas oferecidas. Desses, 62 (63,91%) trabalhavam na RM, médicos em sua maioria (74,22%); 18 (29,03%) atuando somente em instituições públicas e 12 (19,25%) somente em privadas (19,35%); 29,03% tinham doutorado, e 40,32%, mestrado; 50% atuavam na preceptoria havia mais de 20 anos. Na autoavaliação sobre competências pedagógicas, os 30 alunos da primeira turma apontaram aumento de competências pedagógicas em todas as ênfases solicitadas (p < 0,001). Conclusão: O modelo de formação em competências pedagógicas proposto no curso mostrou-se exequível, com baixo índice de desistência e favoreceu a equidade geográfica no cenário nacional, apesar das vagas ociosas. Houve melhoria significante nas competências pedagógicas autorreferidas de docentes/preceptores atuantes na RM, passo importante na qualificação dos próprios programas e residentes.Denise Herdy Afonso; Lia Márcia Cruz da Silveira; Maria Helena Senger; Sandro Schreiber de Oliveira; Oscarina da Silva Ezequiel; Rodrigo Pinheiro Silveira; Aristides Augusto [UNESP] Palhares Neto; Rosiane Viana Zuza Diniz

Context (archaeology); Data collection; Digital literacy; Causal model; Humanities; Psychology; Sociology

2026-01-01https://doi.org/10.1590/1981-5271v50.supl.1-20260158Revista Brasileira de Educação Médica 20261FIGURE 6 in On the type series of Lacerta teguixin Linnaeus, 1758 (Squamata: Teiidae)FIGURE 6. Description of [Lacerta] Teguixin (No. 19) in the sixth edition of Systema Naturae. Left: the Stockholm edition (Linnaeus 1748a, p. 36); right: the Leipzig edition (Linnaeus 1748b, p. 36). The text can be translated as: 19. Lizard with a long, tapering tail, pentadactyl limbs, without crest and with folded sides.Henrique C. Costa; Wolfgang Denzer

Tapering; Series (stratigraphy); Type (biology); Crest; Mathematics; Geometry

2026-05-15https://doi.org/10.5281/zenodo.21178297Zenodo (CERN European Organization for Nuclear Research) 20261FIGURE 3. Plate 96 in On the type series of Lacerta teguixin Linnaeus, 1758 (Squamata: Teiidae)FIGURE 3. Plate 96 from Seba (1734). Specimens from figs 1–3 can be identified as Tupinambis teguixin (Linnaeus, 1758).Henrique C. Costa; Wolfgang Denzer

Series (stratigraphy); Type (biology); Coplanarity; Geometry; Mathematics; Physics; Geology

2026-05-15https://doi.org/10.5281/zenodo.21178291Zenodo (CERN European Organization for Nuclear Research) 20261FIGURE. 10 in On the type series of Lacerta teguixin Linnaeus, 1758 (Squamata: Teiidae)FIGURE. 10. Stuffed specimen of Tupinambis teguixin (UPSZTY 72), labeled as "Lacerta orbicularis". This is not part of the type series of Lacerta teguixin. Credits: Hans Mejlon, curator at the Museum of Evolution, Uppsala University, Sweden.Henrique C. Costa; Wolfgang Denzer

Series (stratigraphy); Type (biology); Body type; Holotype; Mathematics

2026-05-15https://doi.org/10.5281/zenodo.21178307Zenodo (CERN European Organization for Nuclear Research) 20261FIGURE 2 in On the type series of Lacerta teguixin Linnaeus, 1758 (Squamata: Teiidae)FIGURE 2. Description of Lacerta teguixin in Seba (1734: p. 150–151). Latin and French texts are not equal and can be translated as: LATIN SECTION No. 1. Tecuixin lizard, smaller, or Teiuguacu, from New Spain. The scales of the skin are deeply imbued with a saturated cerulean hue, variegated above with the palest bluish-white and white, especially upon the head, thighs, and feet. The tail, even unto its extremity, is wholly adorned with ribbon-like bands. No. 2. Another Tecuixin lizard, or Teiuguacu. In color this one indeed agrees with the former smaller one, yet in its marvelous ornamentation and variegation, here wrought by Nature, it surpassed the other. Let the mind, astonished, marvel at this inimitable ornament, and among created things so varied in color and disposition, behold and adore the omnipotent Creator. FRENCH SECTION No. 1. Small lizard named Tecuixin, or Teiuguacu, from New Spain. The scales which cover its skin are of a turquoise blue, mingled with white and an extremely pale blue, principally upon the head, thighs, and feet. Its tail is entirely adorned with bands fashioned like ribbons. No. 2. Another Tecuixin or Teiuguacu lizard, larger. Its color is the same as that of the preceding one, yet it surpasses it in the admirable variety of markings with which Nature has embellished it. One cannot contemplate this inimitable ornament, so varied among different animals, without being struck with astonishment, and without rising unto a profound adoration of the First Cause of all things.Henrique C. Costa; Wolfgang Denzer

Adoration; Section (typography); Variety (cybernetics); White (mutation); Character (mathematics); Type (biology); Behold; Art; Geology; Art history; Paleontology; Lizard; Stack (abstract data type)

2026-05-15https://doi.org/10.5281/zenodo.21178289Zenodo (CERN European Organization for Nuclear Research) 20261FIGURE. 9 in On the type series of Lacerta teguixin Linnaeus, 1758 (Squamata: Teiidae)FIGURE. 9. Lectotype of Lacerta teguixin (UPSZTY 13) photographed in 2025, desiccated. Credits: Hans Mejlon, curator at the Museum of Evolution, Uppsala University, Sweden.Henrique C. Costa; Wolfgang Denzer

Series (stratigraphy); Type (biology); Mathematics

2026-05-15https://doi.org/10.5281/zenodo.21178306Zenodo (CERN European Organization for Nuclear Research) 20261FIGURE. 8 in On the type series of Lacerta teguixin Linnaeus, 1758 (Squamata: Teiidae)FIGURE. 8. Lectotype of Lacerta teguixin (UPSZTY 13) photographed in the 1990's. Credits: Marinus S. Hoogmoed.Henrique C. Costa; Wolfgang Denzer

Series (stratigraphy); Type (biology); Body type; Mathematics

2026-05-15https://doi.org/10.5281/zenodo.21178302Zenodo (CERN European Organization for Nuclear Research) 20261FIGURE. 7 in On the type series of Lacerta teguixin Linnaeus, 1758 (Squamata: Teiidae)FIGURE. 7. Label on the original Linnaeus jar for Lacerta teguixin, written by Carl Peter Thunberg, his student. Below the species name, it reads "Mus. Gyllenb.", meaning that the specimen comes from the Gyllenborg donation. Credits: Hans Mejlon, curator at the Museum of Evolution, Uppsala University, Sweden.Henrique C. Costa; Wolfgang Denzer

Series (stratigraphy); Type (biology); Meaning (existential); Holotype; Mathematics; Biology

2026-05-15https://doi.org/10.5281/zenodo.21178300Zenodo (CERN European Organization for Nuclear Research) 20261FIGURE 3. Plate 96 in On the type series of Lacerta teguixin Linnaeus, 1758 (Squamata: Teiidae)FIGURE 3. Plate 96 from Seba (1734). Specimens from figs 1–3 can be identified as Tupinambis teguixin (Linnaeus, 1758).Henrique C. Costa; Wolfgang Denzer

Series (stratigraphy); Type (biology); Coplanarity; Geometry; Mathematics; Physics; Geology

2026-05-15https://doi.org/10.5281/zenodo.21178292Zenodo (CERN European Organization for Nuclear Research) 20261FIGURE 1 in On the type series of Lacerta teguixin Linnaeus, 1758 (Squamata: Teiidae)FIGURE 1. Description of Lacerta teguixin in the 10th edition of Systema Naturae (Linnaeus 1758, p. 208). The Latin text can be translated as: Teguixin. 36. Lizard with a cylindrical, long tail; a lateral folded suture. [Amen. acad. 1. p. 128]. Lizard with a cylindrical, long tail, five-toed feet, no crest, abdominal lateral folds. [Mus. Ad. Fr. 1. p. 45; Seb. mus. 1. t. 96. f. 1]. Lives in the Indies. Neck with triple fold below.Henrique C. Costa; Wolfgang Denzer

Lizard; Series (stratigraphy); Type (biology); Domain (mathematical analysis); Mathematics; Anatomy; Geometry

2026-05-15https://doi.org/10.5281/zenodo.21178287Zenodo (CERN European Organization for Nuclear Research) 20261Intelligent integration of data on software ecosystem platforms to support data-intensive applicationsRecent advances in software engineering (SE) and data science emphasize the need for platforms that integrate distributed heterogeneous data sources while maintaining semantic consistency. However, Software Ecosystem Platforms (SECO) often tackle integration and intelligence separately. This paper extends an ecosystem platform, which addresses integration and intelligence to support the development of data-intensive applications. We discuss how ontological inference and AI-based mechanisms can enhance integration. This extension aims to improve data integration, infer missing information, and to automate decisions on a SECO platform. We evaluated the SECO for integrating carbon emissions data to support our claims. As a result, an architecture was extended, and evaluated through an application focused on carbon emissions data context.Pedro Henrique Assis Silva; Luiz Fernando SANTOS; Regina Braga; José David; Victor Ströele; Valdemar Vicente Graciano Neto; Wagner Arbex

Data integration; Software; Inference; Information integration; System integration; Software architecture; Intelligence analysis; Computer science; Software engineering; Data science; Systems engineering

2026-04-12https://doi.org/10.1145/3786163.3788449 20261Ultra-Fast EV Charging Stations in Distribution Grids: Impacts and Hosting Capacity AssessmentCaio Cesar Amorim Silva; Walquíria N. Silva; Bruno H. Dias; Jesús C. Hernández

Distribution (mathematics); Work (physics); Reliability (semiconductor); Production (economics); Environmental science; Remote sensing

2026-01-01https://doi.org/10.1007/978-981-95-7302-8_27Springer proceedings in energy 20261Discrimination experienced by LGBTQIAPN+ individuals and access to dental services: A cross-sectional studyABSTRACT Sexual and gender minority individuals experience discrimination daily, including when seeking health care. This cross-sectional study aimed to investigate the association between discrimina-tion and the seeking of, difficulty in accessing, and recent use of dental services. A total of 762 Brazilian LGBTQIAPN+ individuals completed an online questionnaire on sociodemographic characteristics, experiences of discrimination, and access to dental services. Binary logistic regression analyses were used to estimate the association between independent variables, organized into five blocks, and outcomes related to access to dental services. Results are presented as Odds Ratios (OR) and 95% confidence intervals (95% CI). Overall, 16.8% of participants reported hesitation in attending dental services due to a perceived lack of acceptance regarding their gender identity and sexual orientation; 30.4% had not sought dental services in the past year; and 5.4% reported difficulty accessing them. Discrimination was not associated with the outcomes, but hesitation in attending services remained associated with seeking dental care (OR = 0.55; 95% CI: 0.33-0.91) and with difficulty in accessing services (OR = 4.35; 95% CI: 1.40-13.54). Therefore, although discrimination was not directly associated with access to dental services, this population remains vigilant about the possibility of experiencing discrimination in these settings.Igor Campos Guimarães; Ana Carla Batista Domiciano; Isabel Cristina Gonçalves Leite

Logistic regression; Odds ratio; Population; Odds; Dental care; Association (psychology); Help-seeking; Health care; Medicine; Family medicine; Clinical psychology; Psychology; Confidence interval; Identity (music); Cross-sectional study

2026-01-01https://doi.org/10.1590/2358-2898202614911103iSaúde em Debate 20261Escolarización en contextos de movilidad humana: Una lectura regionalResumen Se examinan los procesos de escolarización de la población migrante/refugiada, a partir de una perspectiva regional (latinoamericana). Para ello, se empleó la caja de herramientas teórico-conceptual que ofrece el pensamiento de frontera/interseccional, en articulación con la interculturalidad crítica. La investigación responde a los criterios de un diseño documental, viabilizada a partir de la revisión de un corpus de 54 artículos científicos. Los ejes tópico-temáticos destacados apuntan a focalizar la atención en: procesos migratorios Sur-Sur; claves de intelección que ofrece el pensamiento de frontera/interseccional; y caminos analíticos/ético-políticos que ofrece la interculturalidad crítica en la intelección de los fenómenos educativos objeto de atención.Rafael Alberto González González

Context (archaeology); Perspective (graphical); Humanity; Humanities; Philosophy; Sociology

2026-01-01https://doi.org/10.1590/1980531411652Cadernos de Pesquisa 20261ATENÇÃO ÀS INFECÇÕES SEXUALMENTE TRANSMISSÍVEIS ENTRE MULHERES EM SITUAÇÃO DE RUA: PERSPECTIVAS DE ENFERMEIRAS(OS) DO CONSULTÓRIO NA RUARESUMO Objetivo: Analisar as práticas de cuidado às mulheres em situação de rua de enfermeiros(as) do Consultório na Rua frente às infecções sexualmente transmissíveis. Método: Estudo descritivo, qualitativo, analisado à luz do conceito de vulnerabilidade. Foram realizadas entrevistas semiestruturadas, por via remota, no período de outubro de 2022 a junho de 2024, com 12 enfermeiras(os) que atuavam no Consultório na Rua na região Norte do Brasil. Resultados: A vulnerabilidade perpassa o cuidado da(o) enfermeira(o) em todas as suas dimensões. Na atuação nas ruas, utilizam-se diferentes estratégias de prevenção, promoção da saúde, diagnóstico e tratamento de infecções sexualmente transmissíveis, encaminhamentos e intervenções no território. Evidencia-se contexto de vulnerabilidade programática no cuidado em rede de atenção às mulheres em situação de rua. Conclusão: As práticas de cuidado às mulheres em situação de rua na prevenção de infecções sexualmente transmissíveis é desafiadora e perpassa as dimensões da vulnerabilidade. As ações realizadas por enfermeiras(os) in loco no território contribuem para a acessibilidade ao cuidado dessa população.Nayara Gonçalves Barbosa; Isabelle de Fatima Fernandes; Natália Maria Vieira Pereira-Caldeira; Lise Maria Carvalho Mendes; Janaína Costa Barreto; Flávia Azevedo Gomes-Sponholz; Lúcia Yasuko Izumi Nichiata; Thaís de Oliveira Gozzo

Context (archaeology); Population; Qualitative research; Ethnography; Participant observation; Sociology; Gender studies; Psychology

2026-01-01https://doi.org/10.1590/1980-265x-tce-2025-0202ptTexto & Contexto - Enfermagem 20261Discriminação experienciada por pessoas LGBTQIAPN+ e acesso aos serviços odontológicos: estudo transversalRESUMO Pessoas de minorias sexuais e de gênero são discriminadas cotidianamente, inclusive ao pro-curar cuidados de saúde. Este estudo transversal objetivou investigar a associação entre discriminação e procura, dificuldade no acesso e uso recente dos serviços odontológicos. 762 indivíduos LGBTQIAPN+ brasileiros responderam a um questionário online sobre suas características sociodemográficas, ex-periências discriminatórias sofridas e acesso a serviços odontológicos. Análises de regressão logística binária estimaram a associação entre variáveis independentes, organizadas em cinco blocos, e desfechos relativos ao acesso aos serviços odontológicos. Os resultados são apresentados em razão de chances (Odds Ratio - OR) e Intervalos de Confiança de 95% (IC 95%). Dos participantes, 16,8% relataram hesitação em frequentar serviços odontológicos por não se sentirem aceitos, 30,4% não os procuraram no último ano e 5,4% tiveram dificuldade em acessá-los. A discriminação não manteve associação à procura, uso recente e dificuldade no acesso aos serviços odontológicos, mas a hesitação em frequentá-los manteve- -se associada à sua procura (OR = 0,55; IC 95%:0,33-0,91) e à dificuldade em acessá-los (OR = 4,35; IC 95%:1,40-13,54). Portanto, indica-se que, apesar da ausência de associação entre discriminação e acesso aos serviços odontológicos, essa população se mantém vigilante em relação à possibilidade de sofrerem discriminação nesses serviços.Igor Campos Guimarães; Ana Carla Batista Domiciano; Isabel Cristina Gonçalves Leite

Data collection; Higher education; Informed consent; Qualitative research; Medicine; Gerontology

2026-01-01https://doi.org/10.1590/2358-2898202614911103pSaúde em Debate 20261ATTENTION TO SEXUALLY TRANSMITTED INFECTIONS AMONG WOMEN EXPERIENCING HOMELESSNESS: PERSPECTIVES OF STREET CLINIC NURSESABSTRACT Objective: To analyze the care practices provided to women experiencing homelessness by Street Clinic nurses in the context of sexually transmitted infections. Method: Descriptive, qualitative study analyzed in light of the concept of vulnerability. Remote semi-structured interviews were conducted between October 2022 and June 2024 with 12 nurses working in the Street Clinic program in the Northern region of Brazil. Results: Vulnerability permeates nursing care in all its dimensions. In street-based practice, nurses employ different strategies for prevention, health promotion, diagnosis and treatment of sexually transmitted infections, as well as referrals and territorial interventions. A context of programmatic vulnerability is evident within the networked care provided to women experiencing homelessness. Conclusion: Care practices aimed at women experiencing homelessness for the prevention of sexually transmitted infections are challenging and traverse multiple dimensions of vulnerability. The actions carried out by nurses in loco within the territory contribute to improving access to care for this population.Nayara Gonçalves Barbosa; Isabelle de Fatima Fernandes; Natália Maria Vieira Pereira-Caldeira; Lise Maria Carvalho Mendes; Janaína Costa Barreto; Flávia Azevedo Gomes-Sponholz; Lúcia Yasuko Izumi Nichiata; Thaís de Oliveira Gozzo

Vulnerability (computing); Context (archaeology); Qualitative research; Health care; Sexually transmitted disease; Nursing; Medicine; Family medicine

2026-01-01https://doi.org/10.1590/1980-265x-tce-2025-0202enTexto & Contexto - Enfermagem 20261Technical–tactical and pacing profiles in European and Pan-American Pre-Olympic boxing qualification tournaments: influence of sex, weight category, and round dynamicsObjective: This study compared the technical–tactical profiles of male and female boxers competing in the European (2021) and Pan-American (2023) Pre-Olympic qualification tournaments, examining differences according to continent, bout outcome, grouped weight categories, and round dynamics. Methods: A total of 138 bouts (414 rounds; 77 men's and 61 women's) were analyzed using a validated time–motion protocol (Frami®). Results: Pan-American boxers of both sexes displayed significantly greater offensive and defensive activity than their European counterparts (all p ≤ 0.001), whereas European men spent more time in clinch situations (p = 0.012). Winning male boxers exhibited greater attacking activity than losing athletes (p = 0.034). Analyses by grouped weight categories revealed continent-specific competitive patterns, with Pan-American middle- and heavyweight boxers demonstrating higher offensive and defensive outputs, while European heavyweights engaged in longer clinch durations (p ≤ 0.05). Across rounds, athletes adjusted their pacing strategy, characterized by reduced attacking activity and increased pause and clinch durations in the final round (p ≤ 0.05). Conclusion: Technical–tactical performance varied according to continent, sex, weight category, bout outcome, and round progression, highlighting distinct competitive profiles in Olympic qualification events. These findings provide practical evidence to support the development of sex- and weight-specific conditioning and tactical strategies for high-level boxing.Mateus Henrique Santos; N. Almeida; José Raimundo Fernandes; Aparecido Pimentel Ferreira; Einstein Francisco Camargos; Otávio de Tolêdo Nóbrega; Esteban Aedo-Muñoz; Ciro José Brito

Offensive; Athletes; Body weight; Competitive athletes; Psychology

2026-05-29https://doi.org/10.47197/retos.v82.119055Retos 20261Distribuição temporal e regional do tratamento de complicações de hidrocefalia no Brasil (2020–2025)INTRODUÇÃO A hidrocefalia é classicamente considerada uma falha na homeostase do líquido cefalorraquidiano, que resulta na expansão ativa dos ventrículos cerebrais. Lactentes com essa condição podem apresentar aumento progressivo do perímetro cefálico, enquanto crianças mais velhas podem apresentar sinais e sintomas de aumento da pressão intracraniana. OBJETIVOS Avaliar a distribuição temporal e regional dos casos de tratamento de complicações de hidrocefalia no Brasil entre 2020 e 2025. METODOLOGIA Foi realizada uma análise epidemiológica retrospectiva, com dados obtidos no banco do Departamento de Informática do Sistema Único de Saúde (DATASUS), referentes ao local de internação nas áreas federativas a partir de 2008 e posteriormente no módulo de morbidade do Sistema de Informações Hospitalares (SIH) do SUS. Foram considerados os registros do procedimento SUS 0303040157 — tratamento de complicações de hidrocefalia — no período de janeiro de 2020 a maio de 2025 (53 meses), independentemente de faixa etária e sexo. RESULTADOS Entre 2020 e 2024, foram registrados 18.296 casos de tratamento de complicações de hidrocefalia no Brasil. O maior número observado foi em 2022, com 3.857 pacientes. As regiões Sudeste e Nordeste concentraram a maioria dos casos ao longo dos anos, com picos em 2023 (Sudeste: 1.299; Nordeste: 1.277) e 2022 (Sudeste: 1.264; Nordeste: 1.249). As demais regiões mantiveram números mais estáveis, com leves oscilações. Em 2024, observou-se discreta redução geral, totalizando 3.692 casos, com destaque para o Sudeste (1.331) e Nordeste (1.092). CONCLUSÃO Houve estabilidade nos casos de tratamento de complicações da hidrocefalia entre 2020 e 2024, com pico em 2022. As regiões Sudeste e Nordeste concentraram a maior parte dos casos, possivelmente relacionada a fatores como densidade populacional, infraestrutura hospitalar e acesso aos serviços de saúde.Izabela Dib Gomes; Aline Rabelo Rodrigues; S Silva; Ivens Rafael Resplande de Sá; Tales Alvarenga Lopes e Silva; Matheus Fernando Manzolli Ballestero

Right hemisphere; Congenital disease; Term (time); Central nervous system disease; Medicine

2026-01-01https://doi.org/10.5327/1516-3180.144s1.016 20261An OpenFOAM based solver for three-phase flow in porous media incorporating foam effectsFoam injection is a promising alternative for enhanced oil recovery strategies, as it can improve sweep efficiency in gas-assisted processes. Accurately predicting multiphase foam flow in porous media, however, remains challenging, and existing modeling approaches continue to evolve as new foam modeling insights and numerical strategies emerge. In this work, we develop ImpesFOAM, a computational framework for three-phase flow incorporating effects of foam using Finite volume method (FVM) formulation within the OpenFOAM framework and IMplicit-Pressure Explicit-Saturation (IMPES) method. Two foam formulations are incorporated: an implicit-texture model that captures dry-out, oil effects, and surfactant concentration, and a mechanistic population-balance model describing bubble generation and coalescence. Surfactant transport in the aqueous phase is modeled through an additional conservation equation that includes adsorption effects. The object-oriented high-level programming design of OpenFOAM facilitates the link between mathematical modeling and computational implementation, which makes the developed solver more flexible for further foam model implementations. The solver is validated against a comprehensive set of benchmark cases for two and three-phase flow, with and without foam, designed to isolate gravity, capillary pressure, well-driven flow with source and sink terms, and surfactant transport mechanisms. The results show good agreement with analytical, numerical, and experimental results. Moreover, through two three-dimensional field application cases, we demonstrate that foam-assisted Enhanced Oil Recovery (EOR) ultimately yields more economically attractive outcomes, including a substantial increase in oil recovery factor and a decrease in the gas-oil ratio production.Anderson de Moura de Moura Ribeiro

Solver; Enhanced oil recovery; Porous medium; Multiphase flow; Bubble; Benchmark (surveying); Flow (mathematics); Computational fluid dynamics; Computer science; Finite volume method; Capillary action; Pulmonary surfactant; Materials science; Process engineering; Mechanics; Porosity; Two-phase flow

2026-06-09https://doi.org/10.52843/cassyni.93c30r 20261A poética do desabrigo em “Poemanto”, de Ricardo Aleixo: coreografia negraThis communication proposal aims to address the work of the Minas Gerais poet Ricardo Aleixo, in its multiple dialogues with the visual and performative arts. In this sense, we will focus mainly on the vestment artwork entitled “Poemanto”, and on the poems “Ensaio para escrever (com) o corpo” (Essay to write (with) the body), from the book Modelos vivos (Aleixo, 2010) and “Meu negro” (My Black Man), from the anthology Pesado demais para a ventania (Too Heavy for the Wind) (Aleixo, 2018). Based on the concept of “corpography (writings of the body)” created by the poet, we will discuss his poetics in relation to the work entitled “Bichos” (Animals), by the Brazilian neo-concrete artist Ligia Clark, as well as his own performative presentation, which revolves around figurations of the black body.Michel Mingote Ferreira de Ázara

Context (archaeology); Constraint (computer-aided design); Work (physics); Perspective (graphical); Field (mathematics)

2026-01-01https://doi.org/10.5935/1980-6914/eletdo18370Todas as letras/Revista Todas as Letras 20261Integrated access and backhaul (IAB) across terrestrial, non-terrestrial, and low-altitude platformsFuad M. Abinader; Sérgio R. Barros; Eduardo Melão; Edelberto Franco Silva; Francisco Parente; João Guilherme; Weskley Mauricio; Sérgio Sakai

Backhaul (telecommunications); Digital subscriber line; Mobile telephony; Scheduling (production processes); Access control; Access network; Computer science; Computer network; Telecommunications

2026-01-01https://doi.org/10.23919/jcn.2025.000120Journal of Communications and Networks 20261Two Decades of Software Architecture Education: State of the Art, Challenges, and Future DirectionsSoftware Architecture is pivotal to the success of software systems, yet teaching it effectively remains an open problem in Software Engineering Education. Its abstraction, cognitive demands, and the need to integrate technical and social skills pose barriers for students and instructors. To address this, we conducted a systematic mapping study of 45 primary studies published between 2005 and 2025, providing the most comprehensive overview of Software Architecture Education to date. Our analysis reveals that curricula still emphasize quality attributes, architectural patterns, documentation, and design processes, while active learning strategies, such as Project-Based Learning, gamification, and flipped classrooms, show a promising yet underexplored impact. At the same time, critical gaps persist: bridging abstraction with practice, designing for heterogeneous cohorts, and aligning educational practices with industry demands remain challenges. By consolidating two decades of research, this study delivers updated evidence, uncovers underexplored areas, and outlines directions for making Software Architecture Education more effective, scalable, and relevant.Maria Clara Ribeiro de Menezes; Pedro Henrique Dias Valle; Alessandreia

Bridging (networking); Software peer review; Social software engineering; Software architecture; Architecture; Resource-oriented architecture; Curriculum; Architecture tradeoff analysis method; Software development; Software engineering; Computer science; Software architecture description; Engineering management; Software; Personal software process; Engineering; Reference architecture; Abstraction

2026-04-12https://doi.org/10.1145/3786580.3786954 20261Administração Política em Escala Mundial: Isolamento, Integração e Autonomia Estratégica no Fórum Econômico Mundial de 2026O objetivo do artigo é explicitar os concorrentes modelos projetados de administração política da economia capitalista mundial a partir dos pronunciamentos de gestores políticos principais no Fórum Econômico Mundial, em Davos, em 2026. Para tanto, foi introduzido a administração política em escala mundial para iluminar os aspectos práticos, teóricos e históricos envolvidos no gerenciamento da acumulação de capital em termos globais. Adotou-se a análise qualitativa dos pronunciamentos delimitados de Alemanha, Canadá, China, Estados Unidos, França e União Europeia, adotando-se as seguintes categorias de análise: tendência, justificação e questão-chave. A análise indicou a existência de três modelos projetados de administração política do relacionamento interestatal: isolamento, integração e autonomia estratégica.Elcemir Paço Cunha; Leandro Theodoro Guedes; Thiago Martins Jorge

Scale (ratio); Autonomy; Context (archaeology); Capital (architecture); Measure (data warehouse); Sociology; Humanities; Psychology; Social psychology

2026-06-30https://doi.org/10.9771/rebap.v18i1.72833Revista Brasileira de Administração Política 20261História Lésbica no BrasilO presente artigo tem como objetivo trazer um debate inicial sobre o desenvolvimento da história das lesbianidades no Brasil. Para isso, realizamos um levantamento bibliográfico a partir de pesquisas acadêmicas sobre o tema na área da História. Através dessa proposta, trazemos algumas reflexões sobre como as ações das mulheres lésbicas ao longo do tempo foram ou não incorporadas por áreas da historiografia como a história das mulheres e história das homossexualidades, discutindo a importância da inserção de pesquisadoras lésbicas nos programas de pós-graduação em História para que as experiências de lesbianidade sejam levadas em consideração na escrita da História.Jessica Marques Toledo; Joyce Mirella Alves de Souza

Face (sociological concept); Field (mathematics); Context (archaeology); Perspective (graphical); Term (time); Humanities; Philosophy; Political science

2026-03-30https://doi.org/10.15210/clio.v10i19.31283Revista Discente Ofícios de Clio 20261Entre o público e o privadoO artigo aprofunda discussões de minha dissertação de mestrado ao analisar dois videodocumentários de Rita Moreira e Norma Bahia Pontes: The Apartment (1975) e Lesbianism Feminism (1974). As produções abordaram temáticas ligadas aos debates feministas do período e levaram à tela imagens de mulheres lésbicas, inserindo-as na narrativa histórica. Busca-se compreender, através dos vídeos, como a esfera pública e a privada foram abordadas pelos movimentos de mulheres nos anos 1970. A análise de The Apartment evidencia o porquê da construção de “um teto todo seu” ser primordial às lésbicas. Já em Lesbianism Feminism, percebe-se como o movimento mobilizou a ocupação do espaço público. O artigo se aproxima teórico-metodologicamente da história das mulheres e da teoria do cinema feminista. Além dos vídeos, também foram usadas entrevistas orais com Rita Moreira.Alina Dos Santos Nunes

Apartment; Feminism; Movie theater; Government (linguistics); State (computer science); Ideology; Order (exchange); Object (grammar); Gender studies; Sociology; Political science; Art

2026-03-30https://doi.org/10.15210/clio.v10i19.31289Revista Discente Ofícios de Clio 20261Envolvimento paterno durante a pandemia da COVID-19.Este estudo objetivou caracterizar a percepção de homens sobre o próprio envolvimento paterno com os filhos antes, durante e logo após a pandemia da Covid-19. Participaram 30 homens adultos residentes em Petrópolis-RJ, pais de crianças matriculadas em escolas particulares. Para a coleta de dados foi elaborado um roteiro semiestruturado aplicado como entrevista. Os pais foram acessados pela técnica bola de neve, considerando os critérios de inclusão (ter filho biológico ou adotivo matriculado no Ensino Fundamental anos iniciais, de escola privada, residir com o filho em Petrópolis-RJ, aceitar participar do estudo assinando o TCLE). As entrevistas foram gravadas. Houve análise de conteúdo, do tipo temático, nas respostas às questões abertas e foram calculadas as porcentagens. Nas questões fechadas houve cálculo das porcentagens das respostas. Os resultados revelaram percepção de aumento do envolvimento paterno durante a pandemia, que se manteve mais elevado após a pandemia, quando comparado com antes de tal período.Lúcia Vaz de Campos Moreira; Luciana Xavier Senra; Ana Da Costa Polonia; Mônica Cristina Batista de Melo; Juliana Monteiro Costa; Fernanda Pinto Monteiro Guimarães; Lílian Perdigão Caixêta Reis

Population; Scientific literature; Statistical analysis; Perception; Humanities; Psychology; Philosophy

2026-05-28https://doi.org/10.54397/rcfaminas.v21i2.1054REVISTA CIENTÍFICA DA FAMINAS 20261Ab initio analysis of Coulomb explosion in ionized moleculesthat exceeds the experimental resolution threshold, leading to spatial delocalization that may obscure the VMI signal. This work provides a computationally efficient methodology for predicting fragmentation patterns and establishes a quantitative link between initial quantum states and experimental observables in ultrafast Coulomb explosion imaging.Marcos D. S. Alves; Ramon S. da Silva; Maikel Y. Ballester

Coulomb explosion; Observable; Fragmentation (computing); Delocalized electron; Ionization; Coulomb; Quantum; Physics; Atomic physics; Work (physics); Ultrashort pulse; Resolution (logic); Molecule; High resolution

2026-01-01https://doi.org/10.1039/d6cp01285jPhysical Chemistry Chemical Physics 20261New records expand the known geographic range of Leposternon cerradense and document its co-occurrence with Leposternon infraorbitale (Squamata: Amphisbaenidae)Supplementary dataset containing the revised geographic distribution records of Leposternon cerradense and Leposternon infraorbitale used in the associated publication.Mileny Otani; Henrique Caldeira Costa

Geographic information system; Range (aeronautics); Distribution (mathematics); Geospatial analysis; Field (mathematics); Geography; Remote sensing; Cartography

2026-06-22https://doi.org/10.5281/zenodo.21402473Zenodo (CERN European Organization for Nuclear Research) 20261Importância da suplementação de fontes de carbono e de nitrogênio para otimização do processo fermentativo empregando bactérias do ácido lático em subprodutos do café - um estudo de revisão.O uso de bactérias do ácido lático para fermentação é uma estratégia amplamente difundida. A fermentação de alimentos com esses microrganismos possibilita a melhora de propriedades biológicas e sensoriais, além da produção de produtos inovadores e funcionais. Nesse contexto, os subprodutos do café, produzidos em grande escala pela indústria cafeeira, apresentam diversas substâncias bioativas que podem ser aprimoradas pela fermentação ácido lática. No entanto, alguns desses subprodutos possuem limitações nutricionais para serem utilizados como meios de cultivo, como a carência de concentrações adequadas de açúcares e aminoácidos necessários para garantir o desenvolvimento microbiano, o que limita a viabilidade e os potenciais benefícios do processo fermentativo. Dessa forma, a suplementação dessas fontes vegetais é uma estratégia relevante para superar restrições nutricionais, a fim de garantir o crescimento e a viabilidade celular e contribuir para a utilização sustentável dos subprodutos do café com condições adequadas para potenciais melhorias funcionais dos substratos. Assim, a presente revisão buscou discutir a importância da suplementação de fontes de carbono e de nitrogênio para a otimização de processos fermentativos empregando bactérias ácido-láticas em subprodutos do café.Mirian Bomfim Fernandes; João Paulo Souza Simão Da Silva; Humberto Moreira Húngaro; Mírian Pereira Rodarte

Process (computing); Diabetes control; Dip-coating; Humanities

2026-05-28https://doi.org/10.54397/rcfaminas.v21i2.1065REVISTA CIENTÍFICA DA FAMINAS 20261New records expand the known geographic range of Leposternon cerradense and document its co-occurrence with Leposternon infraorbitale (Squamata: Amphisbaenidae)Supplementary dataset containing the revised geographic distribution records of Leposternon cerradense and Leposternon infraorbitale used in the associated publication.Mileny Otani; Henrique Caldeira Costa

Geographic information system; Range (aeronautics); Distribution (mathematics); Geospatial analysis; Field (mathematics); Geography; Remote sensing; Cartography

2026-06-22https://doi.org/10.5281/zenodo.21402474Zenodo (CERN European Organization for Nuclear Research) 20261A morte e a morte do maridoA resenha “A morte e a morte do marido: precisamos voltar a falar do lugar simbólico da literatura” analisa o livro de poemas Como matar seu marido, de Laura Cohen Rabelo. O texto destaca o caráter provocador e desconfortável da obra, que desmonta a linguagem patriarcal e desafia convenções de polidez e reverência. Enfatiza-se que o livro subverte o poder simbólico do “marido”, figura que representa não apenas o cônjuge, mas o homem como instituição social, por meio de uma escrita coral, na qual as “ressentidas” e os “cidadãos” revelam o fracasso do matrimônio e a violência simbólica nele implicada.Interpreta-se o gesto de “matar o marido” como um ato simbólico e estético de libertação, em que o assassinato reiterado do marido expressa tanto a dissolução do patriarcado quanto a autotransformação da mulher que o enuncia. Ao final, o texto ressalta que o livro convida à reflexão sobre o papel da literatura como espaço de desobediência, representação e reinvenção da experiência feminina.Flávia Alves Figueirêdo Souza

Expressive power; Power (physics); Context (archaeology); Humanities; Philosophy; Art

2026-03-30https://doi.org/10.35699/2317-2096.2025.62514Caligrama Revista de Estudos Românicos 20261Flexible Channel Estimation and Data Detection with Superimposed Pilots in OTFS SystemsJ. Marcos Leal B. Filho; Danilo De S. Pena; Álvaro A. M. De Medeiros; Vicente A. de Sousa Júnior

Channel (broadcasting); Noise (video); Signal processing; Feature (linguistics); Key (lock); Computer science; Artificial intelligence; Computer vision

2026-01-01https://doi.org/10.1109/ojvt.2026.3714571IEEE Open Journal of Vehicular Technology 20261Comparison of OCT Structural Parameters and OCTA‐Measured Retinal Vessel Density and Peripapillary Choroidal Microvasculature in Glaucoma and Optic Neuritis From Multiple Sclerosis or Neuromyelitis OpticaAims: To compare peripapillary retinal nerve fiber layer (pRNFL), choroidal microvascular dropout (CMvD) and vessel density (pVD), as well as macular ganglion cell complex (GCC) and vessel density (mVD) in eyes with glaucoma and optic neuritis (ON) due to multiple sclerosis (MS-ON) or neuromyelitis optica spectrum disorder (NMOSD-ON) using OCT and OCT angiography (OCTA), and to assess its correlations with visual acuity and visual field (VF) parameters. Methods: Thirty-one eyes (16 patients) with glaucomatous optic neuropathy (GON), 26 eyes (16 patients) with MS-ON, 19 eyes (12 patients) with NMOSD-ON, and 53 healthy eyes (27 subjects) underwent 24-2 VF, OCT, and OCTA. The pRNFL thickness, pVD, and CMvD, as well as macular GCC thickness and mVD, were analyzed and compared using generalized estimating equations. Area under the receiver operating characteristic curves was calculated. Results: All disease groups showed significantly reduced structural parameters compared to controls. MS-ON and NMOSD-ON did not differ and demonstrated greater GCC thinning than GON despite similar pRNFL thickness (except nasally). mVD did not significantly differ among disease groups. In contrast, superficial and deep pVD distinguished the disease groups from controls and were significantly lower in nasal and temporal sectors in MS-ON and particularly in NMOSD-ON compared to GON. Although CMvD occurred in all groups, it was significantly more frequent and extensive in GON. Significant correlations were found between OCTA and OCT and visual function parameters in MS-ON and NMOSD-ON but not in GON eyes. Conclusions: Brazilian Clinical Trials Registry: 76722517.2.0000.0068.Glauco Batista Almeida; João Américo Domingos; Marcelo Hatanaka; Leandro Cabral Zacharias; Leonardo Provetti Cunha; Luiz Guilherme Marchesi Mello; Mário Luiz Ribeiro Monteiro

Optic neuritis; Nerve fiber layer; Neuromyelitis optica; Multiple sclerosis; Retinal; Visual field; Glaucoma; Optic nerve; Medicine; Ophthalmology; Ganglion; Visual acuity; Optic neuropathy; Retinal ganglion cell

2026-01-01https://doi.org/10.1155/joph/6354194Journal of Ophthalmology 20261Le Fort I Osteotomy for Removal of an Extensive Complex Odontoma Involving the Maxillary Sinus: A Case Report and Literature ReviewOdontoma is a common odontogenic tumour in the maxillomandibular region, but its occurrence in the maxillary sinus is rare. Small- to medium-sized odontomas can usually be removed without difficulties, depending on their location and proximity to adjacent structures. Nevertheless, access to extensive odontomas may be complicated. The aim of this study was to report a case of surgical removal of an extensive complex odontoma from within the maxillary sinus by using the Le Fort I osteotomy whilst also providing a review of the existing literature on intrasinus complex odontoma, with particular emphasis on surgical management. A 22-year-old male patient presented with an asymptomatic, well-defined radiopaque lesion in the right maxillary sinus, measuring approximately 40 × 25 × 46 mm. The treatment consisted of surgical removal by using the Le Fort I osteotomy to facilitate access, full excision of the lesion and maintenance of bone integrity. Histological analysis revealed disorganised enamel matrix and dentinoid material with areas of calcification, consistent with the diagnosis of complex odontoma. The 1-year follow-up showed good healing, stable occlusion and no complications. Le Fort I osteotomy may be a safe and effective option for extensive intrasinus complex odontomas, particularly when posterior extension limits conventional access. However, its greater surgical complexity and potential morbidity require careful selection based on lesion size and posterior extension within the sinus.Yuri de Lima Medeiros; Lívia Marques dos Santos; Zarife Tirapani Adum Resende; Bruno Augusto Benevenuto de Andrade; Daniel Amaral Alves Marlière

Odontoma; Osteotomy; Lesion; Maxillary sinus; Odontogenic; Occlusion; Medicine; Dentistry; Maxilla; Odontogenic tumor; Orthodontics; Surgery

2026-01-01https://doi.org/10.1155/crid/3412161Case Reports in Dentistry 20261Speed, agility and dribbling of young Brazilian soccer players: normative data according to chronological age and biological maturationAbstract Physical and technical skill tests are often used in the identification and selection of soccer talent. The objective was to establish reference values for speed, agility and dribbling tests in young Brazilian soccer players, according to chronological age and biological maturation. There was a total of 327 male athletes participating, aged between 12 and 17, from a talent development program. Speed (20 m), agility and dribbling tests were performed, with the 10th, 30th, 50th, 70th, 90th and 98th percentiles being calculated. Somatic maturation was evaluated by the percentage of predicted adult stature. Reference values were reported for the age groups 12, 13, 14, 15, 16 and 17 years, stratified by maturation status. Motor performance and technical skill improve from 12 to 14-15 years and then stabilize. Maturation influences motor performance, but not technical ability. Biologically early athletes showed better performance in the 20 m sprint test when compared to on time athletes at 13 years of age (3.25 ± 0.16s vs. 3.36 ± 0.21s; p=0.01; d=0. 59) and at 14 years old (3.12 ± 0.10s vs. 3.20 ± 0.16s; p=0.049; d=0.62), respectively. Furthermore, at 17 years of age, early athletes were more agile than on time athletes (7.54 ± 0.28s vs. 8.04 ± 0.64s; p=0.03; d=1.09). Significant differences were not observed in dribbling test between biologically on time and early athletes.Hugo Leonardo Barros de Paula; Francisco Zacaron Werneck; Dilson Borges Ribeiro Junior; Lívia Costa dos Reis Souza; Emerson Filipino Coelho; João Carlos Bouzas Marins

Sprint; Biological age; Athletes; Normative; Percentile; Test (biology); Motor skill; Psychology; Age groups; Developmental psychology; Coaching; Young adult

2026-01-01https://doi.org/10.1590/1980-0037.2026v28e112380Brazilian Journal of Kinanthropometry and Human Performance 20261GUT MICROBIOTA ALTERATIONS IN RODENT MODELS OF CHOLESTASIS INDUCED BY BILE DUCT LIGATION: A SYSTEMATIC REVIEWBACKGROUND AND OBJECTIVE: Cholestatic liver diseases are a major public health issue, marked by impaired bile flow and significant disruptions in liver and systemic physiology. Growing evidence points to the gut microbiota as a key player in cholestasis pathogenesis through gut-liver axis interactions. This systematic review aimed to synthesize and evaluate current findings on intestinal microbiota changes in rodents (rats and mice) subjected to bile duct ligation (BDL)-induced cholestasis, focusing on microbial diversity, taxonomic shifts, and potential pathophysiological implications. METHODS: A comprehensive literature search was conducted in PubMed, Scopus, and Embase for studies published from January 2020 to February 2025, following PRISMA guidelines. Eligible studies included original research using BDL in rodents without therapeutic intervention and reporting gut microbiota profiles. Data were qualitatively analyzed, emphasizing experimental conditions and microbiome outcomes. RESULTS: Twenty-two studies met inclusion criteria. Most used 16S rRNA sequencing; two used shotgun metagenomics. BDL consistently induced gut dysbiosis, with reductions in alpha diversity (in most studies), altered beta diversity, and shifts in dominant phyla such as Firmicutes, Bacteroidetes, Proteobacteria, Actinobacteria, and Verrucomicrobiota. At finer taxonomic levels, increases in Prevotella, Enterococcus, Escherichia coli, and Alistipes were common, while Lactobacillus and Ruminococcus often decreased. Elevated levels of Akkermansia muciniphila and Bifidobacterium pseudolongum may represent compensatory microbial responses. CONCLUSION: Bile duct ligation (BDL)-induced cholestasis leads to complex changes in the microbiota that can worsen intestinal barrier integrity, increase bacterial translocation, and intensify liver inflammation. These findings reinforce the central role of the gut-liver axis and corroborate the potential of microbiota-targeted therapies in the management of cholestatic liver diseases. However, as most of the available evidence derives from experimental models, further well-designed clinical studies are needed to validate the safety, efficacy, and translational applicability of these strategies in human diseases.Stephane Lima Calixto; Ana Caroline Lopes de Paula Macedo; Jair Adriano Kopke de Aguiar

Akkermansia muciniphila; Akkermansia; Gut flora; Cholestasis; Microbiome; Bacteroides; Bifidobacterium; Ruminococcus; Metagenomics; Medicine; Dysbiosis; Fusobacteria; Gastroenterology; Bile acid; Lactobacillus; Bile duct; Fusobacterium; Physiology; Internal medicine; Anaerobic bacteria

2026-01-01https://doi.org/10.1590/s0004-2803.24612025-159Arquivos de Gastroenterologia 20261Impacto da pandemia de covid-19 nas notificações de violência: análise temporal, Minas Gerais, 2014-2022Resumo Objetivos Caracterizar as notificações de violência interpessoal e sua tendência temporal e analisar o impacto da pandemia de covid-19 nas notificações por esse agravo em Minas Gerais, de 2014 a 2022. Métodos Estudo de série temporal, que utilizou dados do Sistema de Informação de Agravos de Notificação. Analisaram-se notificações de violência interpessoal em Minas Gerais, 2014-2022, por meio de frequência absoluta e relativa, média e desvio-padrão e incidência de violência, por sexo e ciclo de vida. Utilizou-se o modelo de regressão linear generalizada de Prais-Winsten para estimar o impacto da covid-19 nas notificações, com significância de 5%. Resultados Foram registradas 268.377 notificações de violência no período. Os subgrupos predominantes foram mulheres (70,7%) e pessoas pardas (45,5%). Violência física foi a mais notificada (55,5% em mulheres, 67,6% em homens). Destacaram-se violência sexual em crianças (37,8% em meninas, 19,6% em meninos) e negligência/abandono entre pessoas idosas (13,9% em mulheres, 12,0% em homens). A pandemia impactou a incidência de violência em todos os subgrupos, mesmo naqueles com tendência de crescimento no período pré-pandêmico. Durante o período pandêmico, as incidências se mantiveram aquém dos níveis anteriores, representadas pelo coeficiente de β2 negativos e estatisticamente significativos. Conclusão Mulheres e pessoas pardas foram as mais atingidas pela violência interpessoal em Minas Gerais. As tendências temporais de notificação da violência foram impactadas no período pandêmico em relação ao pré-pandêmico nos ciclos de vida estudados. Demonstrou-se a importância de estratégias de manutenção da vigilância de agravos em tempos de crise sanitária.Dalmo Abrantes Figueiredo Júnior; KAREN DUARTE MOREIRA; Larissa Rocha Manhães Alves; Paloma Dornas de Castro; Waneska Alexandra Alves; Eulilian Dias de Freitas

Human immunodeficiency virus (HIV); Context (archaeology); Health services; Protozoal disease; Medicine; Geography

2026-01-01https://doi.org/10.1590/s2237-96222026v35e20250720.ptEpidemiologia e Serviços de Saúde 20261Impact of the COVID-19 pandemic on reports of violence: a temporal analysis, Minas Gerais state, 2014-2022Abstract Objectives To characterize reports of interpersonal violence and their temporal trend, and to analyze the impact of the COVID-19 pandemic on reports of this type of violence in Minas Gerais state, from 2014 to 2022. Methods Time series study using Notifiable Health Conditions Information System data. Reports of interpersonal violence in Minas Gerais, 2014-2022, were analyzed using absolute and relative frequency, mean and standard deviation, and incidence of violence by sex and stage of life. The Prais-Winsten generalized linear regression model was used to estimate the impact of COVID-19 on reporting, taking a 5% significance level. Results 268,377 reports of violence were recorded during the period. The predominant subgroups were women (70.7%) and mixed-race individuals (45.5%). Physical violence was the most frequently reported (55.5% in women, 67.6% in men). Sexual violence against children stood out (37.8% in girls, 19.6% in boys), as did neglect/abandonment among elderly people (13.9% in women, 12.0% in men). The pandemic impacted the incidence of violence in all subgroups, even those with a rising trend in the pre-pandemic period. During the pandemic, incidence rates remained below previous levels, represented by negative and statistically significant β2 coefficients. Conclusion Women and mixed-race individuals were the most affected by interpersonal violence in Minas Gerais. Temporal trends in violence reporting were impacted during the pandemic compared to the pre-pandemic period in the stages of life studied. The importance of strategies for maintaining surveillance of health problems during times of health crisis was demonstrated.Dalmo Abrantes Figueiredo Júnior; KAREN DUARTE MOREIRA; Larissa Rocha Manhães Alves; Paloma Dornas de Castro; Waneska Alexandra Alves; Eulilian Dias de Freitas

Interpersonal violence; Pandemic; Sexual violence; Incidence (geometry); Suicide prevention; Public health; Occupational safety and health; Poison control; Demography; Notifiable disease; Injury prevention; Medicine; Environmental health; Mental health; Interpersonal communication; Human factors and ergonomics; Domestic violence; Psychology; Geography

2026-01-01https://doi.org/10.1590/s2237-96222026v35e20250720.enEpidemiologia e Serviços de Saúde 20261Fermented water-soluble yam extract: growth kinetics, technological characteristics and sensory evaluationABSTRACT: The shifting behavior of the contemporary population regarding ethical animal welfare concerns has driven an increased demand for plant-based foods and beverages. Thus, this study developed a water-soluble fermented yam extract (FWYE) using commercial strains of Lactobacillus bulgaricus and Streptococcus thermophilus, and evaluated its fermentation kinetics, microbial viability, technological properties during storage and sensory attributes. Lactic acid bacteria (LAB) adapted to the mathematical model within the tested matrix. During the storage period, the pH of the FWYE decreased, with the most pronounced reduction observed on day 21 (3.99), which coincided with the lowest counts of L. bulgaricus (6.73 log CFU/mL) and S. thermophilus (6.68 log CFU/mL). After 28 days of refrigerated storage, FWYE maintained LAB counts above 8.4 log CFU/mL. The technological properties exhibited syneresis values exceeding 77.92% and water retention capacity below 9.38%. For the sensory evaluation, 70 panelists assessed FWYE alongside strawberry-flavored (FWYES) and chocolate-flavored (FWYEC) versions. The highest scores for sensory attributes, as well as the greatest acceptability index (83.8%) and purchase intention (3.97), were recorded for FWYES. The results show that despite technological limitations, the fermented yam beverage proved effective in maintaining the viability of LAB and sensorially promising for consumers with restrictions on dairy consumption.Taynan Jonatha Neves Costa; Larissa Mirelle Mendes Magalhães; Nicole Januzzi; Rafaela Assis Machado; Isabella Maciel Costa; Gabrielle Venâncio Muniz Souza; Vívyan Alice Clemente Vieira; Ana Golo; Lara Mateus; Elisa Helena Paz Andrade; Cosme Damião Barbosa; Gabriel Augusto Marques Rossi; Camila Argenta Fante; Bruna Maria Salotti de Souza

Syneresis; Streptococcus thermophilus; Fermentation; Lactic acid; Population; Lactobacillus; Sensory analysis; Cold storage; Food technology; Food science; Biology; Biotechnology; Fermentation in food processing; Log reduction; Water holding capacity

2026-01-01https://doi.org/10.1590/0103-8478cr20250437Ciência Rural 20261Caminhos para o Esporte ParalímpicoJovens com deficiência apresentam baixos níveis de atividade física e poucas oportunidades de prática esportiva, cruciais para o desenvolvimento integral e a inclusão social. Neste contexto, este estudo analisou o recrutamento, seleção e orientação para iniciação esportiva e participação competitiva de jovens com deficiência em um projeto de extensão universitária, em colaboração com o Comitê Paralímpico Brasileiro. O objetivo foi descrever e avaliar uma estratégia para o fomento à iniciação esportiva paralímpica em idade escolar. Esse estudo se trata de um relato de caso de natureza documental retrospectiva com abordagem descritiva analítica, fundamentada em relatórios do projeto e boletins oficiais de competições (Jogos Escolares de Minas Gerais e Paralimpíadas Escolares – PE) de 2022 a 2024. Para análise, empregou-se estatística descritiva e análise comparativa. Os resultados demonstraram que os festivais paralímpicos foram eficazes na divulgação do esporte paralímpico, contribuindo na captação de novos interessados...Renato de Carvalho Guerreiro; Ciro Winckler; Elke Lima Trigo; Carlos Makleyton Caetano Schuchter; Gustavo Henrique Scarmigliat Cruz; Arthur Henrique Rodrigues Cordeiro; Marco Túlio de Mello; Andressa Silva

Data collection; Descriptive research; Subject (documents); Humanities; Art; Philosophy

2026-06-08https://doi.org/10.22456/1982-8918.148603Movimento (Porto Alegre) 20261Spatial and temporal patterns of Lecane decipiens () records: a global overview based on literatureAbstract: Aim Lecane decipiens (Murray, 1913) was originally described from samples collected at a small lake in downtown Rio de Janeiro, Brazil. It is widely recorded in Central and South America, although the species has been found on other continents. L. decipiens is easily misidentified with other species of the same genus, differentiated only by small details on the lorica, a historical problem in the species occurrence records. This study aims to provide an update on the occurrence of L. decipiens worldwide, investigating its distribution and its potential to be considered cosmopolitan in the tropics and subtropics and invasive in temperate regions, as well as identifying gaps in current knowledge about the species. Methods This study was conducted through a bibliographic survey in scientific databases (Web of Science, Scopus, Scielo, ScienceDirect and Google Scholar). Results After screening and removing duplicates, 84 articles published between 1931 and 2025 were analyzed. The results indicate that L. decipiens can be considered as a cosmopolitan species, accumulating records in seven of the biogeographic regions, with a particular predominance in the countries India and Brazil, where the largest concentration of articles was found. Most studies were conducted in lakes and rivers, and only one article addressed the species' potential ecological impact, considering its negative influence negligible. Additionally, most studies focused on occurrence records rather than ecological interactions or population dynamics. Conclusions Despite the widespread distribution of L. decipiens, the lack of articles on population densities, environmental interactions, and ecological effects hinders the determination of whether the species’ presence outside its original range is due to natural expansion or a silent invasion.Lucas César Santos-Cabral; Manoela dos Santos Moreira; Christina Wyss Castelo Branco

Subtropics; Cosmopolitan distribution; Temperate climate; Population; Tropics; Distribution (mathematics); Ecology; Geography; Biology; Biogeography; Taxonomy (biology)

2026-01-01https://doi.org/10.1590/s2179-975x7625Acta Limnologica Brasiliensia 20261Does the logs decomposition affect epixylic bryophyte communities? A Study in Atlantic Forest Fragments of Northeastern BrazilDecomposing logs play a crucial role in sustaining the diversity of epixylic bryophytes; however, research on this group remains limited. This study sought to examine how log circumference size and decomposition stage influence the richness and composition of epixylic bryophyte communities in Atlantic Forest regions of northeastern Brazil. Bryophyte samples were collected from 40 logs representing three decomposition stages: initial, intermediate, and advanced. Most of the species identified on the sampled logs were from the families Calymperaceae and Lejeuneaceae. The cancellinae structures of Calymperaceae and the lobules of Lejeuneaceae enhance the tolerance of these species to moisture fluctuations, particularly during the early stages of decomposition.The results indicated that variations in bryophyte coverage, richness, and species composition were not significantly associated with either decomposition stage or log circumference. Notably, bryophyte richness and species composition remained consistent across different decomposition stages, suggesting a high level of species coexistence. This pattern may be attributed to the availability of abundant resources and reduced competition in this substrate type.Jailton Venilson Ferreira da Silva; Hermeson Cassiano de Oliveira; Pedro Manuel Villa; Emília de Brito Valente

Bryophyte; Species richness; Decomposition; Atlantic forest; Lejeuneaceae; Competition (biology); Species diversity; Composition (language); Ecology; Substrate (aquarium); Biology; Biodiversity; Interspecific competition; Rainforest

2026-01-01https://doi.org/10.1590/0001-3765202620250117Anais da Academia Brasileira de Ciências 20261Association between incidence of dental caries and body mass index among preschool children: a longitudinal studyBody mass index (BMI) disorders and dental caries are common and interrelated conditions in children, sharing risk factors such as inadequate diet and socioeconomic factors. This longitudinal study was designed to improve understanding of the determinants of children's health and, consequently, to promote health from childhood. The research was conducted between August 2017 and November 2018 in Diamantina, Brazil, and investigated the association between the incidence of dental caries and BMI in preschool children. The final sample included 122 children aged three to four years and 11 months, who were evaluated at two points over a one-year interval. The analysis showed that reduced family income (RR = 3.94; 95%CI: 1.26-12.39) and the incidence of caries (RR = 1.86; 95%CI: 1.01-3.42) were significant risk factors for low weight. Although maternal education initially appeared relevant (RR = 4.67; 95%CI: 1.48-14.73), its influence diminished when family income was considered. In conclusion, this study found an association between incidence of dental caries and low BMI (underweight) in preschoolers after one year of follow-up. The incidence of caries and the reduction or maintenance of low monthly family income were identified as risk factors for low weight in preschoolers during one year of follow-up.Maria Eliza da Consolação Soares; André Souza Rufino; Júlia Fernandes Siqueira; Valéria Silveira Coelho; T. M. Rego; Maria Letícia Ramos‐Jorge; Joana Ramos‐Jorge

Incidence (geometry); Longitudinal study; Body mass index; Socioeconomic status; Low income; Family income; Association (psychology); Dental health; Medicine; Demography; Environmental health; Obesity; Dentistry; Risk factor; Oral health; Epidemiology

2026-01-01https://doi.org/10.1590/1807-3107bor-2026.vol40.042Brazilian Oral Research 20261MANAGEMENT OF CLOSTRIDIOIDES DIFFICILE INFECTION IN INFLAMMATORY BOWEL DISEASE: A SYSTEMATIC REVIEW AND META-ANALYSIS OF ANTIBIOTIC EFFICACYBACKGROUND: Clostridioides difficile infection (CDI) is a significant complication in patients with inflammatory bowel disease (IBD), often associated with higher recurrence rates, increased morbidity, and complex therapeutic decision-making. The optimal antibiotic regimen for CDI in IBD remains uncertain. OBJECTIVE: To evaluate the efficacy of different antibiotic therapies for CDI in patients with IBD. METHODS: A systematic review and meta-analysis were conducted according to PRISMA 2020 guidelines. Searches were performed in MEDLINE, EMBASE, PubMed, Epistemonikos, and the Cochrane Library through October 2024. Observational studies and clinical trials comparing antibiotic regimens in adult IBD patients with CDI were included. Data on recurrence, clinical outcomes, colectomy, and mortality were extracted. Random-effects meta-analysis was performed when appropriate. RESULTS: Nine studies involving 643 patients met inclusion criteria. Recurrence occurred in 17.4% of patients treated with metronidazole and 8.2% of those treated with vancomycin. In the meta-analysis of four studies (n=214), vancomycin showed a trend toward lower recurrence, although not statistically significant (OR 0.55; 95%CI 0.15-1.99; P=0.36; I2=66%). Mortality was low and similar between groups, and colectomy occurred exclusively in patients with ulcerative colitis. Data on clinical success and adverse events were heterogeneously reported and summarized narratively. CONCLUSION: Vancomycin may be associated with lower recurrence in higher-risk IBD patients; however, available evidence remains limited and heterogeneous. Treatment decisions should be individualized, and further prospective, IBD-specific studies are needed to clarify optimal management strategies.Isadora Brandão Pelucio; Carla Malaguti; Túlio Medina Dutra de Oliveira; Karoline Maria de Souza Marques Chitarra; Maria Cristina Vasconcellos Furtado; Júlio Maria Fonseca Chebli

Metronidazole; Clostridioides; Adverse effect; Antibiotics; Inflammatory bowel disease; Observational study; Fidaxomicin; Vancomycin; Regimen; Clinical trial; Medicine; Internal medicine; Colectomy; Inclusion and exclusion criteria; Systematic review; Complication; Cochrane Library; Surgery; Intensive care medicine; MEDLINE; Disease; Retrospective cohort study; Randomized controlled trial; Incidence (geometry)

2026-01-01https://doi.org/10.1590/s0004-2803.24612025-145Arquivos de Gastroenterologia 20261Acute associations between high-intensity cross-training and executive function in female athletesAim: This study explored the acute association between a high-intensity cross-training benchmark and executive function performance in female athletes. Methodology: A convenience sample of trained female athletes (age: 29.17 ± 6.75 years; training experience: 29.83 ± 16.63 months) completed the Five-Digit Test (FDT) and underwent physiological assessments, including blood pressure, heart rate, and blood lactate concentration, before and immediately after the WOD Fran benchmark. A within-subject pre–post design was adopted. Paired Student’s t-tests were used to compare cognitive and physiological variables between moments, with the level of statistical significance set at p ≤ 0.05. Results: Significant pre–post differences were observed in several executive function–related measures, including counting time, choice time, shifting time, inverse memory, inhibitory control, and cognitive flexibility. Discussion: These findings indicate that acute exposure to a high-intensity functional exercise bout is associated with measurable changes in executive function performance and physiological responses in female athletes. Conclusion: Although causality cannot be inferred due to the pre-experimental design and absence of a control condition, the results provide exploratory evidence supporting a link between acute cross-training exercise and executive function dynamics, contributing to the understanding of psychophysiological responses to high-intensity exercise in this population.Michele Andrade de Brito; José Raimundo Fernandes; Diego Ignácio Valenzuela Pérez; Esteban Aedo–Muñoz; Ciro José Brito; Felipe Guimarães Teixeira; Pedro Henrique Berberth Carvalho; Bianca Miarka

Athletes; Cognition; Association (psychology); Executive functions; Test (biology); Set (abstract data type); Cognitive flexibility; Trail Making Test; Blood lactate; Medicine; Psychology; Physical therapy; Physical medicine and rehabilitation; Causality (physics); Clinical psychology; Analysis of variance

2026-05-29https://doi.org/10.47197/retos.v81.108041Retos 20261Kinematic and anthropometric variables associated with temporal efficiency in elite judo techniques: a comparison of harai-goshi and uchi-mataObjective: To investigate the associations of anthropometric and kinematic variables with temporal efficiency in the harai-goshi and uchi-mata techniques in elite judokas, and to compare performance between sexes. Methods: Forty elite judokas (12 women, 28 men) performed three maximal-speed repetitions of each technique in a motion capture. Kinematic variables (time, linear and angular velocities and accelerations of the foot, knee, and hip) were evaluated across the approach, turning, and throw phases. Anthropometric measures included body mass, height, body mass index (BMI), and lower-limb length. Two-way mixed ANOVA compared techniques and sexes, while Random Forest and multiple linear regression identified variables associated with total execution time. Results: Harai-goshi was performed faster than uchi-mata in both men (0.9 ± 0.2 vs. 1.1 ± 0.2 s) and women (0.8 ± 0.2 vs. 1.2 ± 0.3 s; p ≤ 0.004). Men showed higher foot velocities and accelerations in specific phases (p ≤ 0.04), with no sex-by-technique interaction. Kinematic variables consistently showed stronger associations with execution time than anthropometric variables. For uchi-mata, hip angular velocity during the throw phase was the strongest predictor, whereas for harai-goshi, BMI, hip angular velocity during the turning phase, and foot linear velocity during the approach were most important. Conclusions: Temporal efficiency in elite judo techniques was more strongly associated with kinematic than anthropometric variables. Harai-goshi was executed faster than uchi-mata, and the variables associated with execution time differed between techniques, highlighting the importance of optimizing movement velocity, coordination, and timing to improve technical performance.N. Almeida; Ignacio Roa Gamboa; Lindsei Brabec Mota Barreto; Felipe J. Aidar; Otávio de Tolêdo Nóbrega; Bianca Miarka; Esteban Aedo-Muñoz; Ciro José Brito

Kinematics; Anthropometry; Angular velocity; Linear regression; Elite; Regression analysis; Body height; Mathematics; Statistics; Physical medicine and rehabilitation; Motion analysis; Physical therapy; Linear relationship; Biomechanics

2026-05-08https://doi.org/10.47197/retos.v82.119217Retos 20261Comparative Analysis of SDAP and PHA for Two-Stage Stochastic Electricity Market Clearing Problems With Energy and Reserve Co-OptimizationThis work presents a comparative analysis of the Scenario Decomposition with Alternating Projections (SDAP) and the Progressive Hedging Algorithm (PHA) applied to a two-stage stochastic electricity market problem under both risk-neutral and risk-averse settings, the latter modeled using Conditional Value at Risk (CVaR). The formulation is evaluated on a market-clearing problem with co-optimization of energy and reserve (E&R) under wind power uncertainty. The choice of this short-term market allocation and pricing problem is particularly relevant because, although its deterministic formulations that neglects uncertainties are widely used, the application of stochastic programming approaches still requires further investigation for real-world implementations in electricity markets. The results indicate that the SDAP and PHA-based approaches exhibit similar computational performance, with marginal differences in execution time. However, SDAP achieves higher computational efficiency, with speed-ups of 21.3% and 18.3% compared to PHA and its SVA-enhanced variant, respectively. In contrast, PHA-based approaches provide a better trade-off among optimality, stability, and robustness, particularly under risk-averse conditions. These findings highlight the trade-offs between computational efficiency and solution quality, providing guidance for selecting decomposition techniques in stochastic electricity market applications.de Oliveira MF; Bruno H. Dias; Hugo Morais

Clearing; Electricity; Market clearing; Electricity market; Energy (signal processing); Energy consumption; Natural resource economics; Environmental economics; Computer science; Business; Electricity generation; Consumption (sociology)

2026-01-01https://doi.org/10.1109/access.2026.3716587IEEE Access 20261Efficacy and Safety of Encorafenib and Binimetinib as First-Line Therapy for BRAFV600-Mutant Metastatic or Unresectable Melanoma: A Systematic Review and Meta-AnalysisAll articles of this category (opens in new window) Address for correspondence Cecília Leite Dias (cecilialeited@gmail.com) Introduction: The first-line treatment for metastatic melanoma harboring the BRAF V600 mutation, found in approximately 50% of melanoma cases, consists of targeted therapies that include BRAF and MEK inhibitors, such as encorafenib and binimetinib (E/B). In recent years, several studies have evaluated the efficacy and safety of this combination, demonstrating promising outcomes compared to other therapeutic approaches . Objective: To evaluate the efficacy and safety of the combination of encorafenib and binimetinib in patients with BRAFV600-mutant metastatic melanoma when used as first-line therapy. This meta-analysis aims to synthesize current clinical evidence to support treatment decisions in the first-line setting . Methods: A systematic review and meta-analysis were conducted, with searches performed in Embase, PubMed, and the Cochrane Library to identify articles published up to June 2025. We included retrospective studies and clinical trials of any phase that assessed this drug combination as a first-line treatment. Studies where encorafenib and binimetinib were not used in the first-line setting were excluded. The review protocol was prospectively registered on PROSPERO (CRD420251078839). Data extraction and risk of bias assessment were performed independently by three reviewers. This process followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A single-arm meta-analysis was performed to synthesize data on disease control; complete, partial, and overall response rates, progression-free survival, and treatment-related adverse events . Results: We included six studies comprising a total of 122 patients. The pooled overall response (ORR) rate was 72% (95% CI: 66–78), with a partial response (PR) rate of 64% (95% CI: 55–72) and a complete response (CR) rate of 3% (95% CI: 0–17). The disease control rate (DCR) was 78% (95% CI: 42–100). The median progression-free survival (PFS) was 8.3 months (95% CI: 1.4–15.3). On average, patients experienced six adverse events each, with 40% of patients experiencing grade ≥3 events . Conclusion: This systematic review and meta-analysis supports the efficacy and safety profile of the combination of E/B as a first-line therapeutic option for patients with BRAFV600-mutant metastatic melanoma. These results reinforce its role as a promising strategy and emphasize the importance of ongoing research to confirm long-term benefits. Publication History Article published online: 26 June 2026 © 2026. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit (https://creativecommons.org/licenses/by/4.0/) Thieme Revinter Publicações Ltda. Rua Rego Freitas, 175, loja 1, República, São Paulo, SP, CEP 01220-010, Brazil Bibliographical Record Nathália Meneses Neves, Cecília Leite Dias, Paulo Ricardo Melo Santos, Gustavo Perrone. Efficacy and Safety of Encorafenib and Binimetinib as First-Line Therapy for BRAFV600-Mutant Metastatic or Unresectable Melanoma: A Systematic Review and Meta-Analysis. Brazilian Journal of Oncology 2026; 22. DOI: 10.1055/s-0046-1825449Nathália Meneses Neves; C M C Cristiane Maria Costa Dias; Paulo Ricardo Melo Santos; Gustavo Perrone

Adverse effect; Clinical trial; MEDLINE; Systematic review; Cochrane Library; Metastatic melanoma; Melanoma; Medicine; Intensive care medicine; Alternative medicine; Data extraction; Disease; Oncology

2026-06-26https://doi.org/10.1055/s-0046-1825449Brazilian Journal of Oncology 20261Efficacy and Safety of Immunotherapy Prior to Encorafenib and Binimetinib for BRAFV600-Mutant Patients with Metastatic or Unresectable Melanoma: A Systematic Review and Meta-AnalysisAll articles of this category (opens in new window) Address for correspondence Paulo Ricardo Melo Santos (pauloricardo72011@hotmail.com) Introduction: Targeted therapies such as encorafenib and binimetinib have improved outcomes in BRAFV600-mutant metastatic melanoma, but their efficacy may be limited in some cases. Immune checkpoint inhibitors have shown significant benefit, yet current evidence is based on early-phase, limited-scope trials, affecting robustness and applicability . Objective: This meta-analysis aims to synthesize current clinical evidence to support treatment decisions and evaluate the efficacy and safety of the combination of encorafenib and binimetinib in patients with BRAFV600-mutant metastatic melanoma previously treated with immunotherapy . Methods: A single-arm systematic review and meta-analysis was conducted, including studies published up to June 2025 from Embase, PubMed, and Cochrane. The protocol was registered in PROSPERO (CRD420251078839). Eligible studies evaluated immunotherapy followed by Encorafenib and Binimetinib. Studies involving only targeted therapy, concomitant use of targeted therapy and immunotherapy, or targeted therapy followed by immunotherapy were excluded. Three reviewers independently screened studies and extracted data in accordance with PRISMA guidelines, using Rayyan software. Statistical analyses were performed with RevMan 5.4. Primary outcomes included response rates, disease control, progression-free survival, adverse events, and treatment discontinuation . Results: A total of five studies comprising 182 patients were included. The pooled overall response rate was 70% (95% CI: 59–80), with a partial response rate of 46% (95% CI: 19–73) and a complete response rate of 6% (95% CI: 2–9). The disease control rate, including complete response, partial response, and stable disease, was 88% (95% CI: 77–98). The median progression-free survival was 9.05 months (95% CI: 3.71–14.39). For safety outcomes, patients experienced a mean of six treatment-related adverse events, with 58% experiencing events of any grade (95% CI: 0.00–1.17) and 28% experiencing grade ≥3 adverse events (95% CI: 0.00–0.58). The treatment discontinuation rate was 35% (95% CI: 0.00–0.86) . Conclusion: This study supports the efficacy and safety of the combination of encorafenib and binimetinib as a therapeutic option for patients with BRAFV600-mutant metastatic melanoma previously treated with immunotherapy. To strengthen current evidence, additional high-quality studies are needed to confirm and expand these findings, supporting more informed clinical decision-making. Publication History Article published online: 26 June 2026 © 2026. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit (https://creativecommons.org/licenses/by/4.0/) Thieme Revinter Publicações Ltda. Rua Rego Freitas, 175, loja 1, República, São Paulo, SP, CEP 01220-010, Brazil Bibliographical Record Nathália Meneses Neves, Paulo Ricardo Melo Santos, Cecília Leite Dias, Gustavo Perrone. Efficacy and Safety of Immunotherapy Prior to Encorafenib and Binimetinib for BRAFV600-Mutant Patients with Metastatic or Unresectable Melanoma: A Systematic Review and Meta-Analysis. Brazilian Journal of Oncology 2026; 22. DOI: 10.1055/s-0046-1825450Nathália Meneses Neves; Paulo Ricardo Melo Santos; C M C Cristiane Maria Costa Dias; Gustavo Perrone

Discontinuation; Immunotherapy; Adverse effect; Metastatic melanoma; Clinical trial; Targeted therapy; Tolerability; Melanoma; Medicine; Oncology; Intensive care medicine; Internal medicine; Ipilimumab; Disease; Randomized controlled trial

2026-06-26https://doi.org/10.1055/s-0046-1825450Brazilian Journal of Oncology 20261Time to Immunohistochemistry Testing for Breast Cancer According to Type of Healthcare CoverageAll articles of this category (opens in new window) Address for correspondence Paulo Ricardo Melo Santos (pauloricardo72011@hotmail.com) Introduction: Immunohistochemistry is a crucial diagnostic tool for determining the molecular subtype of breast cancer, guiding therapeutic decisions and directly impacting patient survival. In Brazil, access to immunohistochemistry testing remains limited in certain settings, potentially contributing to disparities in oncologic care. Objective: To analyze the performance of immunohistochemistry testing and the time interval between diagnosis and result availability in women with breast cancer, according to type of health care coverage (public vs. private). Methods: This retrospective cohort study included 427 women diagnosed with breast cancer between 2014 and 2016, followed at oncology referral centers in the Zona da Mata region of Minas Gerais, Brazil. Access to immunohistochemistry testing and turnaround time were compared between the public and private healthcare sectors. The Kaplan-Meier method was employed to estimate time to result. Results: Complete immunohistochemistry testing was performed in 89% of cases, 88.0% in the public sector and 90.4% in the private sector. A significantly higher proportion of women in the public health system experienced delays greater than 30 days in obtaining test results (70.3%) compared to those in the private system (25.1%) (p<0.001). Conclusion: Marked disparities were observed in the time of immunohistochemistry testing between the public and private sectors, which may hinder timely therapeutic decision-making. These findings underscore the urgent need for policies that promote equitable access to cancer diagnosis and treatment nationwide. Publication History Article published online: 26 June 2026 © 2026. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit (https://creativecommons.org/licenses/by/4.0/) Thieme Revinter Publicações Ltda. Rua Rego Freitas, 175, loja 1, República, São Paulo, SP, CEP 01220-010, Brazil Bibliographical Record Paulo Ricardo Melo Santos, Amanda Laviola de Almeida, Eduarda Silva Kingma Fernandes, Rafaela Russi Ervilha, Angelica Atala Lombelo Campos, Jane Rocha Duarte Cintra, Maximiliano Ribeiro Guerra, Maria Teresa Bustamante Teixeira. Time to Immunohistochemistry Testing for Breast Cancer According to Type of Healthcare Coverage. Brazilian Journal of Oncology 2026; 22. DOI: 10.1055/s-0046-1825222Paulo Ricardo Melo Santos; Amanda Laviola de Almeida; Eduarda Silva Kingma Fernandes; Rafaela Russi Ervilha; Angélica Atala Lombelo Campos; Jane Rocha Duarte Cintra; Maximiliano Ribeiro Guerra; Maria Teresa Bustamante Teixeira

Immunohistochemistry; Breast cancer; Referral; Retrospective cohort study; Health care; Cohort; Medicine; Internal medicine; Oncology; Public healthcare; Public health; Family medicine; Test (biology); Cancer; Cohort study

2026-06-26https://doi.org/10.1055/s-0046-1825222Brazilian Journal of Oncology 20261DANDO CORPO AO DIABO: REPRESENTAÇÕES MEDIEVAIS DO TENTADOR E SUA INSERÇÃO NO DISCURSO DO PODER EM PORTUGAL TARDO MEDIEVALThis article aims to analyze the process of constructing the image of the Devil in the Middle Ages, highlighting its insertion in the discourses of power of the Church and in the structures of temporal power. It is argued that the Devil, together with his legion of demons, was mobilized as an instrument of fear and social control in the service of ecclesiastical interests. The investigation starts from a broad approach to the representations of evil and the Devil, and then focuses on the context of the 15th century, a moment of transition of Western society towards modernity, with a specific focus on the Portuguese territory. We adopt a methodological approach that combines the analysis of religious sources—such as hagiographies, biblical texts, and sermons—with the examination of legal documents, including the Alfonsine Ordinances and the Letters of Pardon.Ismael da Silva Nunes; Marciléia Pereira Do Carmo

Context (archaeology); Middle Ages; Power (physics); Portuguese; Focus (optics); Social control; Sociology; History; Humanities; Art

2026-01-29https://doi.org/10.55028/jbp4e562Revista Trilhas da História 20261Associations of sarcopenia and malnutrition risks with mortality among hospitalized older adults: a retrospective cohort studySarcopenia and malnutrition are highly prevalent in older adults and are associated with reduced function, exacerbation of diseases and mortality. This study aimed to assess the prevalence of nutritional risk, malnutrition, sarcopenia risk, and malnutrition-sarcopenia syndrome risk in hospitalized older adults and investigate the association between these clinical conditions and one-year mortality. Retrospective cohort study was conducted to analyze screening data for malnutrition and sarcopenia in older adults admitted to a hospital. The Kaplan-Meier curve and the adjusted Cox proportional hazards model were used for data analysis. A total of 2,425 older adults were assessed. Prevalence of nutritional risk (48.2%), malnutrition (33.9%), sarcopenia risk (40%), and malnutrition-sarcopenia syndrome risk (39.1%) was found. Malnutrition (HR 2.17; 95%CI 1.30-3.61; p = 0.003) and malnutrition-sarcopenia syndrome risk (HR 1.20; 95%CI 1.10-1.31; p < 0.001) increased the risk of one-year mortality. Immediate intervention in cases of older adults identified with malnutrition and at risk for malnutrition-sarcopenia syndrome at admission can effectively improve the health services provided for this population.Adriana Keller Coelho; Daniele Sirineu Pereira; Ully Aléxia Caproni Corrêa; Laura Keller Coelho de Oliveira; Debora Bertolin Duarte; Maria Marta Amâncio Amorim; Sílvia Lanziotti Azevedo da Silva; Leani Souza Máximo Pereira

Sarcopenia; Malnutrition; Retrospective cohort study; Proportional hazards model; Cohort study; Cohort; Exacerbation; Medicine; Risk factor; Risk assessment; Pediatrics; Comorbidity; Gerontology

2026-01-01https://doi.org/10.1590/1413-81232026316.09592024Ciência & Saúde Coletiva 20261Toxoplasmose em gestantes na atenção básica: um estudo transversal sobre soroprevalência e fatores associadosRESUMO Objetivo: Estimar a soroprevalência de toxoplasmose em gestantes atendidas na atenção básica e investigar as variáveis sociodemográficas, obstétricas e comportamentais associadas à soropositividade. Método: Estudo transversal, realizado com 145 gestantes saudáveis, de risco habitual, residentes em Juiz de Fora, Minas Gerais, a partir de um questionário estruturado e dados de registros de exames sorológicos. A análise incluiu estatísticas descritivas e inferencial, com nível de significância de 5% e análise multivariada. Resultados: A soroprevalência de toxoplasmose foi de 35,2%. Gestantes soropositivas apresentaram média de idade mais elevada (p < 0,001) e maior número de gestações prévias (p = 0,005). Houve associação com a presença de roedores no domicílio (p < 0,001) e desconhecimento sobre a doença (p = 0,008). Na análise multivariada, a idade materna foi identificada como fator associado (p = 0,012). Conclusão: A maioria das gestantes mostrou-se suscetível à toxoplasmose, reforçando a importância do rastreamento e de ações educativas no pré-natal.Nayara Gonçalves Barbosa; SOFIA MARIA LOPES BRAGA AYRES GARGIULLO; LETÍCIA DA CRUZ SILVA; Marcos Morais Santos Silva; Silvia Regina Marin da Motta; Lúcia Yasuko Izumi Nichiata; Flávia Azevedo Gomes-Sponholz

Pregnancy; Toxoplasmosis; Context (archaeology); Medicine; Gynecology

2026-01-01https://doi.org/10.1590/ce.v31i0.102030ptCogitare Enfermagem 20261A obra visionária de Antonin ArtaudResumo O presente estudo buscou compreender a obra de Antonin Artaud a partir do modo visionário de criação artística, conforme delineado por Carl Gustav Jung. Metodologicamente, trata-se de uma pesquisa qualitativa, teórica e documental, fundamentada na psicologia analítica, baseada na análise de cartas e textos literários de diferentes períodos da obra de Artaud. Conclui-se que a compreensão da obra de Artaud como visionária apresenta elevada relevância teórica, metodológica e interpretativa, contribuindo para o desenvolvimento de pesquisas futuras no campo acadêmico e interdisciplinar dos estudos sobre arte e cultura. Essa ampliação interpretativa favorece um olhar para além de abordagens estritamente biográficas ou psicopatológicas, reconhecendo a obra em seu valor simbólico e culturalmente significativo, bem como sua possível função compensatória diante da consciência coletiva de sua época, cujas problemáticas permanecem atuais na cultura contemporânea.Hortênsia Isabela Santos Vieira; Walter Melo

Value (mathematics); Individuation; Field (mathematics); Philosophy; Humanities

2026-01-01https://doi.org/10.1590/0103-6564e237125Psicologia USP 20261A organização político-profissional em Minas Gerais no processo de renovação críticaResumo: O artigo apresenta estudo sobre o Serviço Social em Minas Gerais (1960-1990) no processo de renovação crítica, analisando a construção da cultura política e a organização política da categoria. Destaca-se o “Método BH”, bem como o papel do Sindicato de Assistentes Sociais em Minas Gerais e do Conselho Regional de Assistentes Sociais. A pesquisa contou com revisão bibliográfica, documental e entrevistas. Conclui-se que a articulação dessas instâncias foi crucial para consolidar uma cultura política crítica.Thaíse Seixas Peixoto de Carvalho; Carina Berta Moljo

Work (physics); Process (computing); Field (mathematics); Data collection; Government (linguistics); Social change; Political science; Business; Welfare economics; Sociology

2026-01-01https://doi.org/10.1590/0101-6628.558Serviço Social & Sociedade 20261Toxoplasmosis in pregnant women in primary care: a cross-sectional study on seroprevalence and associated factorsABSTRACT Objective: To estimate the seroprevalence of toxoplasmosis in pregnant women attending primary care and to investigate the sociodemographic, obstetric, and behavioral variables associated with seropositivity. Method: Cross-sectional study conducted with 145 healthy pregnant women at usual risk, residing in Juiz de Fora, Minas Gerais, using a structured questionnaire and data from serological test records. The analysis included descriptive and inferential statistics, with a significance level of 5% and multivariate analysis. Results: The seroprevalence of toxoplasmosis was 35.2%. Seropositive pregnant women had a higher mean age (p < 0.001) and a greater number of previous pregnancies (p = 0.005). There was an association with the presence of rodents in the home (p < 0.001) and lack of knowledge about the disease (p = 0.008). In the multivariate analysis, maternal age was identified as an associated factor (p = 0.012). Conclusion: Most pregnant women were susceptible to toxoplasmosis, reinforcing the importance of screening and educational actions during prenatal care.Nayara Gonçalves Barbosa; SOFIA MARIA LOPES BRAGA AYRES GARGIULLO; LETÍCIA DA CRUZ SILVA; Marcos Morais Santos Silva; Silvia Regina Marin da Motta; Lúcia Yasuko Izumi Nichiata; Flávia Azevedo Gomes-Sponholz

Seroprevalence; Toxoplasmosis; Multivariate analysis; Pregnancy; Serology; Prenatal care; Risk factor; Disease; Medicine; Obstetrics; Primary care; Statistical significance; Gynecology; Public health; Cross-sectional study; Demography; Test (biology); Pediatrics

2026-01-01https://doi.org/10.1590/ce.v31i0.102030enCogitare Enfermagem 20261Toxoplasmosis en mujeres embarazadas atendidas en atención primaria: un estudio transversal sobre seroprevalencia y factores asociadosRESUMEN Objetivo: Estimar la seroprevalencia de toxoplasmosis en mujeres embarazadas que acuden a atención primaria e investigar las variables sociodemográficas, obstétricas y conductuales asociadas a la seropositividad. Método: Estudio transversal realizado con 145 mujeres embarazadas sanas con riesgo habitual, residentes en Juiz de Fora, Minas Gerais, mediante un cuestionario estructurado y datos de registros de pruebas serológicas. El análisis incluyó estadística descriptiva e inferencial, con un nivel de significancia del 5%, y análisis multivariante. Resultados: La seroprevalencia de toxoplasmosis fue del 35,2%. Las mujeres embarazadas seropositivas presentaron una mayor edad promedio (p < 0,001) y un mayor número de embarazos previos (p = 0,005). Se observó una asociación con la presencia de roedores en el hogar (p < 0,001) y la falta de conocimiento sobre la enfermedad (p = 0,008). En el análisis multivariado, la edad materna se identificó como un factor asociado (p = 0,012). Conclusión: La mayoría de las mujeres embarazadas fueron susceptibles a la toxoplasmosis, lo que refuerza la importancia de las pruebas de detección y las acciones educativas durante la atención prenatal.Nayara Gonçalves Barbosa; SOFIA MARIA LOPES BRAGA AYRES GARGIULLO; LETÍCIA DA CRUZ SILVA; Marcos Morais Santos Silva; Silvia Regina Marin da Motta; Lúcia Yasuko Izumi Nichiata; Flávia Azevedo Gomes-Sponholz

Toxoplasmosis; Primary health care; Population; Protozoal disease; Humanities; Medicine; Gynecology

2026-01-01https://doi.org/10.1590/ce.v31i0.102030esCogitare Enfermagem 20261Rhizosphere dynamics in soil recovery by Leucaena leucocephala mining tailing-contaminated substrates from the Fundão Dam failureOne alternative for soil quality restoration is the use of microorganisms that enhance plant development and contaminant bioavailability. This study evaluated the microbial community in the absence and presence of Leucaena leucocephala cultivated in mining tailings from the Fundão Dam collapse, Mariana, Brazil. Substrates included 0, 25, 50, 75, and 100% tailings. Plant growth, total organic carbon (TOC), respiration, and rhizosphere prokaryote density were analyzed. Plant development decreased with higher tailing proportions, while TOC increased in the presence of leucaena. Comparisons between treatments with and without leucaena revealed higher TOC in 0 and 50% tailings. Microbial activity, measured as CO₂ release, was maintained in 25% tailings, matching the control. Prokaryote density was similar across all treatments with leucaena; among tailing treatments, only the 25% condition was statistically comparable to the substrate without tailings. These results indicate that L. leucocephala contributes to improving organic carbon and sustaining microbial communities under tailing-contaminated conditions. Recovery of microbial activity is more effective when tailings are mixed with fertile substrates, highlighting the potential of combining plants and microbial processes for bioremediation of degraded areas.J A de Miranda; Dionéia Evangelista Cesar; Alessandro Del’Duca; Paulo Henrique Pereira Peixoto; Cristiano Ferrara de Resende; Raíza Azevedo; Julliane Dutra Medeiros; Marcelo de Oliveira Santos; Edmo Montes Rodrigues

Leucaena leucocephala; Rhizosphere; Tailings; Bioremediation; Microbial population biology; Leucaena; Total organic carbon; Microorganism; Environmental science; Agronomy; Revegetation; Ecological succession

2026-01-01https://doi.org/10.1590/0001-3765202620250906Anais da Academia Brasileira de Ciências 20261Archiving the Unfolding Present: Digital Memory, Crisis, and the Democratic Future of HistoryIan Kisil Marino; Thorsten Wübbena; Yannis Gürlich

Democracy; Work (physics); Government (linguistics); Field (mathematics); Political science; Public relations; Public administration

2026-06-01https://doi.org/10.5281/zenodo.21676794Zenodo (CERN European Organization for Nuclear Research) 20261Archiving the Unfolding Present: Digital Memory, Crisis, and the Democratic Future of HistoryIan Kisil Marino; Thorsten Wübbena; Yannis Gürlich

Democracy; Work (physics); Government (linguistics); Field (mathematics); Political science; Public relations; Public administration

2026-06-01https://doi.org/10.5281/zenodo.21676795Zenodo (CERN European Organization for Nuclear Research) 20261Getulio Vargas’ Information Network During Afrânio de Melo Franco Tenure at the Ministry of Foreign Affairs, 1931–1933Filipe Queiroz de Campos

Christian ministry; Presidential system; Ministry of Foreign Affairs; Presidential address; Constitutionalism; Term (time); Diplomacy; Political science; Public administration; Foreign policy; Library science; Engineering; Control (management)

2026-01-01https://doi.org/10.1007/978-3-032-32804-5_3The Latin American studies book series 20261Between the Estado Novo and the Outbreak of the Second World War: The Tenure of Oswaldo Aranha (1938–1944)Filipe Queiroz de Campos

Latin Americans; Consolidation (business); World War II; Work (physics); Loyalty; Political science; Geography; Economic history; Economy; History; Ethnology

2026-01-01https://doi.org/10.1007/978-3-032-32804-5_5The Latin American studies book series 20261Informants and Conflicts in the Administration of José Carlos De Macedo Soares (1934–1936)Filipe Queiroz de Campos

Rivalry; Administration (probate law); Institutionalisation; World War II; Spanish Civil War; Nazism; Control (management); Political science; Law; Sociology; Plague (disease); Cold war

2026-01-01https://doi.org/10.1007/978-3-032-32804-5_4The Latin American studies book series 20261Final RemarksFilipe Queiroz de Campos

Impartiality; Power (physics); Politics; Foreign policy; Intersection (aeronautics); International relations; Political science; Sociology; Law; Government (linguistics)

2026-01-01https://doi.org/10.1007/978-3-032-32804-5_7The Latin American studies book series 20261The Second World War: Vargas and his InformantsFilipe Queiroz de Campos

Dismissal; Order (exchange); Cold war; Period (music); Public opinion; Political science; History; Economic history; Law; Government (linguistics)

2026-01-01https://doi.org/10.1007/978-3-032-32804-5_6The Latin American studies book series 20261The Foreign Policy of the Revolutionaries, 1930 to 1933Filipe Queiroz de Campos

Foreign policy; Politics; Christian ministry; Foreign relations; International relations; Diplomacy; Political science; International trade; Political economy; Economy; Foreign policy analysis; Ministry of Foreign Affairs; Public administration

2026-01-01https://doi.org/10.1007/978-3-032-32804-5_2The Latin American studies book series 20261IntroductionFilipe Queiroz de Campos

Foreign policy; Bureaucracy; State (computer science); Historiography; Power (physics); Politics; Core (optical fiber); Political science; Public administration; Sociology; Foreign policy analysis; Process (computing); Government (linguistics); International relations

2026-01-01https://doi.org/10.1007/978-3-032-32804-5_1The Latin American studies book series 20261Esferocitose hereditária no período neonatal: uma revisãoA esferocitose hereditária (EH) é uma anemia hemolítica genética, caracterizada por glóbulos vermelhos esféricos e inflexíveis devido a mutações em proteínas da membrana eritrocitária. A condição pode ser autossômica dominante (75% dos casos) ou recessiva (25%), com maior prevalência em populações europeias. Foi realizada uma revisão integrativa a fim de avaliar e sintetizar publicações científicas com informações atualizadas sobre a Esferocitose Hereditária Neonatal. Os sintomas variam de assintomáticos a graves, incluindo anemia severa, icterícia intensa e, raramente, hidropsia fetal em neonatos. O diagnóstico é desafiador devido à variabilidade dos sintomas e limitações dos testes laboratoriais, sendo que ferramentas como hemograma completo, esfregaço sanguíneo e testes especializados são utilizados, com o sequenciamento de nova geração (NGS) emergindo como uma opção mais cara e limitada. O tratamento depende do quadro clínico. A fototerapia é essencial para neonatos, transfusões de hemácias são necessárias em casos graves, e a suplementação de ácido fólico é recomendada. A esplenectomia pode ser indicada, melhorando a qualidade de vida. Após a esplenectomia, profilaxia com vacinas e antibióticos é crucial para prevenir infecções. O manejo personalizado é vital para melhorar o prognóstico e a qualidade de vida dos pacientes com EH. Ao melhorar o conhecimento sobre a EH neonatal, aumentam-se as chances de diagnóstico e tratamento oportunos, prevenindo complicações.Fernanda Gabriele Fernandes Morais; Luíza Miranda Silva; Sabrine Teixeira Ferraz Grünewald

Fetus; Anemia; Intensive care unit; Medium term; Medicine; Gynecology

2026-06-30https://doi.org/10.18616/inova.v16i2.9196Inova Saúde 20261Stochastic Multi-Objective Optimization for Grid-Scale Energy Storage Sizing and SitingLucas Santiago Nepomuceno; Arthur Neves de Paula; Edimar J. de Oliveira; Leonardo Willer de Oliveira

Sizing; Energy storage; Stochastic optimization; Energy (signal processing); Production (economics); Stochastic process; Computer science; Mathematical optimization; Process engineering; Environmental science; Energy consumption; Storage tank

2026-01-01https://doi.org/10.1109/access.2026.3719146IEEE Access 20261The transition between research, entrepreneurship and innovation: The case of an ecosystem orchestrating organisationJoão Paulo Nascimento Silva; Felipe Mendes Borini

Entrepreneurship; Transition (genetics); Ecosystem; Business; Economic system; Economic geography; Economics; Industrial organization; Economy

2026-01-01https://doi.org/10.7819/rbgn.v28i2.4351Review of Business Management 20261Genetic diversity of native populations of Roncador (mouriri guianensis aubl.) from the Amazon and Mato Grosso PantanalDue to the significant ecological, economic, and medicinal potential of roncador (Mouriri guianensis Aubl.), it is essential to understand the genetic diversity and distribution of this species, especially as no study has been conducted on its genetic composition. Therefore, the study aimed to evaluate the genetic diversity and structure in natural populations of roncador using ISSR molecular markers. Genetic analyses were performed on roncador populations occurring naturally in the state of Mato Grosso, Brazil, in four locations: Rio Cuiabá (Barão do Melgaço), Rio São Lourenço (Poconé), and Rio Jauru (Cáceres) in the Pantanal Biome, and Rio Sepotuba (Cáceres) in the Amazon. For molecular characterization, eight ISSR primers were selected, resulting in 127 amplified fragments (98% polymorphism). AMOVA showed greater genetic diversity among populations (52%). The highest diversity indices were found for the Rio Jauru population (H=0.28; I=0.41, and P%=71.65). UPGMA clustering analysis formed five distinct genetic groups based on collection locations, while Bayesian analysis formed two groups according to biomes. Principal Coordinates Analysis corresponded with UPGMA and Bayesian clustering, isolating the Rio Sepotuba population (Amazon). ISSR molecular markers revealed genetic diversity among roncador individuals, highlighting population structuring among different collection locations and biomes, suggesting the importance of conserving native populations of the Amazon and Mato Grosso Pantanal.Larissa Lemes dos Santos; Julliane Dutra Medeiros; Carolina Joana da Silva; Eliane Cristina Moreno de Pedri; Giovana Cuchi; Ana Paula Roveda; Anderson Ortiz Alves; A Alves; Joari Costa de Arruda; Juliana de Freitas Encinas Dardengo; Ana Aparecida Bandini Rossi

Genetic diversity; UPGMA; Amazon rainforest; Population; Genetic variation; Genetic structure; Genetic similarity; Biology; Ecology; Geography; Analysis of molecular variance; Population genetics; Genetic divergence; Genetic variability; Genetic distance

2026-04-16https://doi.org/10.5902/2179460x87630Ciência e Natura 20261Transtornos de imagem corporal e transtornos alimentares: aspectos nutricionais, psicológicos e implicações do exercício físico no tratamentoEste capítulo aborda os transtornos alimentares e de imagem corporal, destacando suas definições, classificações e principais características clínicas. São discutidos transtornos como anorexia nervosa, bulimia nervosa, transtorno da compulsão alimentar e outros quadros relacionados, bem como suas causas multifatoriais e implicações à saúde. Além disso, são exploradas as relações com a insatisfação corporal e a influência sociocultural contemporânea. São apresentadas as principais estratégias de tratamento, com ênfase na abordagem multidisciplinar e no papel do exercício físico como ferramenta terapêutica, quando adequadamente orientado, visando à recuperação integral, à melhora da qualidade de vida e à promoção de uma relação mais saudável com o corpo e a alimentação.Ana Catarina Gomes; Moacyr Tavares de Medeiros Neto; Ana Carolina Oliveira Simões; Géssyca Tolomeu de Oliveira; Ana Vitória Fortes dos Reis; Kleber Barbora Filho; Danilo Reis Coimbra

Quality of life (healthcare); Mood; Cognition; Eating disorders; Anorexia nervosa; Psychosocial; Psychology; Developmental psychology; Psychotherapist

2026-01-01https://doi.org/10.37885/260321461Editora Científica Digital eBooks 20261Fructooligosaccharides modulate intestinal fermentation and immune response during Giardia lamblia infection in Meriones unguiculatusGiardia lamblia infection alters gut physiology and microbiota interactions, but the impact of prebiotic supplementation in this context remains unclear. This study investigated how fructooligosaccharide (FOS) treatment affects microbial fermentation, intestinal function, inflammation, and hepatic bile acid synthesis in G. lamblia-infected gerbils. Gerbils were divided into four groups: uninfected control, infected control, uninfected and FOS-treated, and infected and FOS-treated. Cecal short-chain fatty acids (SCFAs), intestinal disaccharidase activities, serum and intestinal cytokines, and hepatic expression of Cyp7a1 and Cyp8b1 were analysed. Giardia infection increased cecal acetate, reduced butyrate, elevated serum TNF-α, and increased hepatic Cyp7a1 expression. FOS supplementation increased cecal propionate and other SCFAs and elevated IL-10 levels in serum and intestinal tissue. Notably, FOS reduced intestinal maltase activity regardless of infection status, without affecting lactase activity. Together, these data indicate that giardiasis alters microbial fermentation and inflammatory responses, whereas FOS supplementation primarily promotes a more regulatory immune profile, characterized by increased IL-10 levels, alongside shifts in microbial fermentation, without directly modifying hepatic bile acid-related gene expression. These findings highlight complex diet-microbiota-host interactions during intestinal parasitic infection and support further mechanistic studies.Dirce Ribeiro de Oliveira; Michelle B. M. P. Antunes; Veridiane Miranda De Oliveira; Ruth Elizabeth Cruz; Maria Aparecida Gomes

Immune system; Fructooligosaccharide; Prebiotic; Cecum; Context (archaeology); Short-chain fatty acid; Giardia lamblia; Gut flora; Bile acid; Propionate; Biology; Microbiology; Maltase; Intestinal mucosa; Fermentation; Immunology; Giardia

2026-01-01https://doi.org/10.1590/0001-3765202620250973Anais da Academia Brasileira de Ciências 20261An oxidative-to-glycolytic metabolic continuum underlies muscle metabolic specialization in commercial and local pig genetic groupsNatanieli Silva Máximo; Giarlã Cunha da Silva; Layla Cristien de Cássia Miranda Dias; Francelly Geralda Campos; Paula da Fonseca‐Pereira; M. L. Chizzotti; Renata Veroneze; Simone Guimarães

Skeletal muscle; Glycolysis; Gene; Gene expression; Transcriptional regulation; Metabolic pathway; White (mutation); Metabolism; Transcriptome; Biology; Large white; Muscle tissue; Regulation of gene expression; Oxidative phosphorylation; Genetics; New Zealand white rabbit; Cell biology; Endocrinology; Internal medicine; Metabolic regulation; Metabolic rate

2026-01-01https://doi.org/10.2139/ssrn.7198320SSRN Electronic Journal 20261Determination of iodine content in foods produced by family farmersAbstract Monitoring iodine consumption is important for preventing related diseases. Objective: quantify the iodine content in foods produced by family farmers in the Geographic Region of Viçosa, Minas Gerais, Brazil. Methods: samples of lettuce, cabbage, beans, cornmeal, milk, honey, eggs, coffee powder and cheese were collected from 306 households in eight cities. The colorimetric method was used to quantify iodine in food samples. Data analyzes were carried out using the Statistical Program for Social Science (SPSS) version 21.0. It was verified whether there was a difference in the concentration of iodine in foods between different cultivars, cities and seasons using the Mann Whitney and Kruskal-Wallis test, with multiple comparisons using the Dunn test. Results: 580 samples were analyzed. No difference was found between lettuce, cabbage and bean cultivars. There was a difference between cities in the iodine content of eggs (p ≤ 0.001), cheese (p = 0.028) and milk (p = 0.001). No difference was found between the seasons regarding the iodine content in cabbage and lettuce. Conclusion: the determination of iodine in foods is characterized as an initial study for the inclusion of iodine in food composition tables.Sílvia Oliveira Lopes; Edna Miranda Mayer; Sabrina Silva de Oliveira; Jérsica Martins Bittencourt; Edimar Aparecida Filomeno Fontes; Ricardo Henrique Silva Santos; Sylvia do Carmo Castro Franceschini; Sílvia Eloiza Priore

Iodine; Significant difference; Statistical analysis; Food contaminant; Food preparation; Food products; Food science; Toxicology; Chemistry; Food composition data; Food consumption; Environmental science

2026-01-01https://doi.org/10.1590/1413-81232026317.09722024enCiência & Saúde Coletiva 20261Determinação do teor de iodo em alimentos produzidos por agricultores familiaresMonitoring iodine consumption is important for preventing related diseases. OBJECTIVE: quantify the iodine content in foods produced by family farmers in the Geographic Region of Viçosa, Minas Gerais, Brazil. METHODS: samples of lettuce, cabbage, beans, cornmeal, milk, honey, eggs, coffee powder and cheese were collected from 306 households in eight cities. The colorimetric method was used to quantify iodine in food samples. Data analyzes were carried out using the Statistical Program for Social Science (SPSS) version 21.0. It was verified whether there was a difference in the concentration of iodine in foods between different cultivars, cities and seasons using the Mann Whitney and Kruskal-Wallis test, with multiple comparisons using the Dunn test. RESULTS: 580 samples were analyzed. No difference was found between lettuce, cabbage and bean cultivars. There was a difference between cities in the iodine content of eggs (p ≤ 0.001), cheese (p = 0.028) and milk (p = 0.001). No difference was found between the seasons regarding the iodine content in cabbage and lettuce. CONCLUSION: the determination of iodine in foods is characterized as an initial study for the inclusion of iodine in food composition tables.Sílvia Oliveira Lopes; Edna Miranda Mayer; Sabrina Silva de Oliveira; Jérsica Martins Bittencourt; Edimar Aparecida Filomeno Fontes; Ricardo Henrique Silva Santos; Sylvia do Carmo Castro Franceschini; Sílvia Eloiza Priore

Statistical analysis; Context (archaeology); Trustworthiness; Quality (philosophy); Significant difference; Food science; Biology

2026-01-01https://doi.org/10.1590/1413-81232026317.09722024Ciência & Saúde Coletiva 20261After 53 years, a new record of Ornithomya ambigua (Diptera: Hippoboscidae) and other reports of bird louse flies from the state of Minas GeraisABSTRACT Hippoboscidae is a family of hematophagous ectoparasitic flies of mammals and birds, commonly known as louse flies. In Brazil, 30 species have been previously recorded, of which three parasitize mammals and 27 parasitize birds. Few studies have documented the occurrence of these flies in the state of Minas Gerais, Brazil, which currently counts 11 bird-parasitizing species. In this work, we report hippoboscid flies associated with avian hosts in Minas Gerais. Birds were captured using mist nets across five forest fragments in the Zona da Mata region during field campaigns conducted between 2013 and 2017. Avian hosts were examined for the presence of ectoparasites, and louse flies were collected using fine tweezers. Morphological photographs were taken, and morphometric measurements and a diagnostic assessment were performed for our sample of Ornithomya ambigua (Lutz, Neiva & Costa-Lima, 1915). In total, we examined 2,226 birds belonging to 133 species, of which 24 individuals were parasitized. We collected 30 louse flies belonging to five species within the subfamily Ornithomyinae. Our morphometric measurements of O. ambigua are in agreement with previous studies. Although these five louse fly species had already been recorded for Minas Gerais, six new host-parasite interactions were documented, including the first record of any hippoboscid in three bird species and two Passeriformes genera. Furthermore, we recorded O. ambigua after 95 years without records in Brazil and 53 years since its last record globally. Our results expand the knowledge on this poorly studied group of ectoparasites.EDUARDO BRONCA BERNAVA; Ralph Maturano; Gustavo Graciolli

Louse; Host (biology); Feather; Subfamily; Genus; Biology; Zoology; Ecology

2026-01-01https://doi.org/10.1590/s1984-4689.v43.e25078Zoologia (Curitiba) 20261Persistence of respiratory deficits in post-COVID-19 patients: 36 months after hospital dischargeAbstract Introduction: COVID-19, caused by SARS-CoV-2, is an acute respiratory infection with high transmissibility and multiple complications, particularly pulmonary. Patients who required invasive mechanical ventilation (IMV) are at increased risk of long-term respiratory sequelae. Objective: To investigate the presence of respiratory deficits in post-COVID-19 individuals, 36 months after hospital discharge, who underwent IMV. Methods: A cross-sectional study conducted between December 2023 and May 2024 with patients discharged from the intensive care unit between November 2020 and August 2021. Sociodemographic data, Maximum Inspiratory Pressure (MIP), Maximum Expiratory Pressure (MEP), and dyspnea using the Medical Research Council (mMRC) scale were collected. Statistical analysis was performed using R software, with paired Student's t-tests and Fisher's exact test (p < 0.05). Results: Of the 149 eligible patients, 31 comprised the final sample. The mean age was 54.27 ± 14.59 years, and the mean body mass index was 32.52 ± 4.88 kg/m2. A significant reduction in MIP was observed in the age groups 20–29 years (53% of predicted), 30–39 years (86%), and 50–59 years (72%). MEP was higher among older adults aged 70–79 years (119% of predicted). There was an association between inspiratory muscle weakness and the duration of neuromuscular blocker (NMB) use (p = 0.047), as well as a correlation between dyspnea and comorbidities (p = 0.04). Conclusion: The study identified a reduction in MIP among younger individuals, with an association between inspiratory muscle weakness and NMB duration, as well as between dyspnea and comorbidities. These findings highlight the importance of continuous respiratory rehabilitation and personalized clinical care.Anderson Procópio Viana; Isabella Luz Assolari; Andreane Daniele Barbosa de Lira; Alexandra Ignes Bruni Túlio; Heloísa Rodrigues Alves Bobato; Regina Helena Senff Gomes; Zaqueline Fernandes Guerra; Arlete Ana Motter

Respiratory system; Mechanical ventilation; Weakness; Ventilation (architecture); Intensive care unit; Muscle weakness; Hospital discharge; Rehabilitation; Body mass index; Medicine; Anesthesia; Physical therapy; Pediatrics; Internal medicine; Persistence (discontinuity); Statistical significance

2026-01-01https://doi.org/10.1590/fm.2026.39121Fisioterapia em Movimento 20261Atividades aquáticas na educação básica: dificuldades de implementação e oportunidades pedagógicasO estudo explorou as perspectivas de professores de Educação Física sobre a implementação de natação/atividades aquáticas em escolas com piscina, envolvendo seis docentes de quatro instituições (duas públicas e duas privadas). Entrevistas semiestruturadas com dezessete questões foram conduzidas remotamente e os dados foram analisados por análise de conteúdo. Os resultados indicam que, apesar da infraestrutura, há dificuldades como falta de recursos, tempo limitado, necessidade de formação continuada e sobrecarga de trabalho. A inclusão de conteúdos de segurança aquática no currículo é vista como essencial para ensinar habilidades de sobrevivência, mas sua implementação é desafiadora, agravada pela reforma do Novo Ensino Médio, que limita a viabilidade dessa prática no Ensino Básico.Aléxia Victória Campos Moreira; Priscila Augusta Ferreira Campos; Renato Melo Ferreira; Géssyca Tolomeu de Oliveira

Action (physics); Government (linguistics); Order (exchange); Work (physics); Data collection; Process (computing); Political science

2026-05-20https://doi.org/10.5216/rpp.v29.83369Pensar a Prática 20261Resenha de HUGHES, Langston. O Negro declara e outros poemas. Tradução Léo Gonçalves. São Paulo: Pinard, 2022Publicado em 2022, "O negro declara e outros poemas" é a primeira antologia de poesia de Langston Hughes editada no Brasil. A resenha crítica faz breves apontamentos sobre suas principais características presentes em alguns dos seus poemas, como a relação temática e estético-formal com os estilos musicais negros, a denúncia do racismo e a valorização da identidade negra.Ricardo Silva Ramos de Souza

Poetics; George (robot); Identity (music); Art; Humanities

2026-03-17https://doi.org/10.5902/1679849x90698Literatura e Autoritarismo 20261Fascismo y anticomunismo en Perú: el «aprocomunismo» como factor de radicalización del proyecto de la Unión Revolucionaria (1931-1936)El artículo analiza la transformación del discurso anticomunista del partido político Unión Revolucionaria (UR). Se examina la adaptación de su red conceptual en el período de 1931 a 1936, una etapa marcada por la transición desde un nacionalismo de derecha a una ideología abiertamente fascista. Para este fin, se estudia la prensa oficial del partido desde el marco teórico de la Historia Conceptual. En su fase inicial, la UR empleó el neologismo «aprocomunismo» para identificar y combatir a la oposición aprista. No obstante, tras su fascistización, el discurso se reorientó para alinearse con categorías transnacionales más definidas como «comunismo» y «aprismo», y reorganizó su vocabulario y acción política en el contexto del gobierno de Óscar Benavides.Tamires de Moura Nogueira Rosa

Context (archaeology); Order (exchange); Statistical analysis; Humanities; Political science; Art

2026-06-03https://doi.org/10.37840/ragn.v40i1.180Revista del Archivo General de la Nación 20261Notas sobre solidões queer através do filme Todos Nós DesconhecidosEste trabalho tem como objetivo problematizar o conceito de solidões queer a partir das provocações desencadeadas pelo filme Todos Nós Desconhecidos. A solidão neste trabalho é compreendida como um modo de produção de si, por meio das subjetividades, especialmente aquelas relacionadas à sexualidade. Para tanto, a pesquisa se inspira nos conceitos de solidão em Michel Foucault e Friedrich Nietzsche, articulando-os aos estudos queer e ao novo cinema queer, com vistas às problematizações de gêneros e sexualidades presentes no filme. A metodologia utilizada é a análise do discurso de inspiração foucaultiana, com a seleção de cenas que evidenciam os processos de solidão e de constituição de si. Conclui-se que o filme possibilita discussões e inquietações sobre as solidões de pessoas LGBTQIAPN+, destacando esse estado como um companheiro de suas existências. Questiona-se, assim, a busca por um/a parceiro/a, entendendo-a como uma norma social e uma expectativa ligada à lógica da completude do sujeito. Além disso, argumenta-se que a solidão integra o processo de constituição dos sujeitos, por meio do cuidado e experiência de si, atravessados pela subjetividade da sexualidade.John Jamerson da Silva Brito

Queer; Movie theater; Subjectivity; Michel foucault; Art; Humanities; Philosophy; Sociology

2026-03-05https://doi.org/10.9771/cgd.v12i1.68880Cadernos de Gênero e Diversidade 20261Modelagem Computacional do Crescimento Cerebral Utilizando a Teoria do Crescimento FinitoO dobramento cortical é crucial para o desenvolvimento cerebral, e alterações nesse processo podem gerar distúrbios neurológicos, evidenciando sua relevância clínica, como em casos de microcefalia associada ao vírus Zika. Estudos indicam que mecanismos mecânicos desempenham papel fundamental nesse fenômeno. Este trabalho investiga a influência de parâmetros físicos na formação de sulcos e giros por meio de um modelo computacional baseado na mecânica do contínuo e na teoria do crescimento finito, resolvido via elementos finitos. Os resultados concordam com a literatura, indicando a influência mecânica no dobramento cortical e que, no contexto do Zika, a redução do crescimento cortical levou a padrões semelhantes à microcefalia.Alexsandro Pattiele Rosa Guimarães; Flávia de Souza Bastos; Bernardo Martins Rocha

Context (archaeology); Nonlinear model; Statistical analysis

2026-06-01https://doi.org/10.5753/sbcas_estendido.2026.21178 20261Impacto dos Marcadores de Posicionamento Anatômico na Detecção de Câncer de Mama por TermografiaO câncer de mama permanece como um dos principais desafios de saúde pública, sendo fundamental o diagnóstico precoce. Nesse contexto, a termografia tem sido investigada como estratégia complementar por não ser invasiva, livre de radiação ionizante e de baixo custo operacional. Na literatura sobre classificação de imagens termográficas da mama, estratégias de segmentação da região de interesse são adotadas para eliminar ruídos e destacar informações fisiológicas relevantes. No entanto, podem também remover elementos que desempenham papel funcional no processo de aprendizado. Este estudo investiga a influência de um marcador comumente presente em imagens termográficas no desempenho de modelos de aprendizado profundo para identificação do câncer de mama. Os resultados indicam que preservar o marcador melhora o desempenho, sugerindo que ele atua como uma referência espacial e evidenciando a necessidade de avaliar criticamente estratégias de segmentação e pré-processamento.João Augusto Pilato de Castro; Fabrício Araújo Filgueiras; Luíza Machado Costa Nascimento; Heder Soares Bernardino; Saulo Moraes Villela

Perspective (graphical); Electrodiagnosis; Term (time); Medicine

2026-06-01https://doi.org/10.5753/sbcas_estendido.2026.21613 20261Modelagem e otimização de posicionamento de eletrodos para auxílio ao tratamento ETCC para portadores de microcefaliaO vírus Zika (ZIKAV), transmitido pelo Aedes aegypti, tornou-se uma emergência global devido à sua ligação com a microcefalia, uma condição neurológica que exige novas estratégias terapêuticas. No entanto, essa é uma patologia que afeta predominantemente populações em situação de vulnerabilidade socioeconômica e que recebem pouca atenção da indústria farmacêutica por não oferecerem retornos lucrativos atrativos, sendo considerada uma doença tropical negligenciada. Este trabalho propõe um modelo personalizado para simulação e otimização da Estimulação Transcraniana por Corrente Contínua (ETCC) em pacientes com microcefalia, visando superar as limitações de ferramentas padrão em anatomias atípicas. Utilizando imagens de ressonância magnética de cada paciente, gerou-se malhas tridimensionais de elementos finitos para modelar a distribuição do potencial elétrico via equação de Laplace. Para otimizar o posicionamento dos eletrodos e a intensidade da corrente, implementou-se um algoritmo genético com inicialização via K-means em ambiente Python, utilizando a biblioteca FEniCS para lidar com os métodos dos elementos finitos. Os resultados demonstraram que o modelo é estatisticamente robusto e capaz de direcionar a estimulação de forma coerente para a região-alvo, apresentando-se como uma alternativa viável para o planejamento terapêutico individualizado em casos de Síndrome Congênita do Zika.João Paulo Silva de Freitas; Joventino Oliveira Campos; Carolina Ribeiro Xavier

Work (physics); Constraint (computer-aided design); Event (particle physics); Physics; Nuclear medicine; Medicine

2026-06-01https://doi.org/10.5753/sbcas_estendido.2026.25331 20261Modeling the Immune Response with Machine Learning: Validation and Computational Cost Analysis of PINNs Compared to Neural Networks and Finite Volume MethodsThis work investigates deep neural networks as surrogate models for simulating the spatiotemporal dynamics of the immune response in infectious myocarditis. A reduced PDE model describing pathogen–leukocyte interactions in myocardial tissue is solved using a finite volume method (FVM), whose solutions are used to train conventional neural networks (NNs) and physicsinformed neural networks (PINNs). The approaches are systematically compared in terms of predictive accuracy and computational performance. Results show that conventional NNs reproduce the reference FVM solution more accurately than PINNs, which exhibit excessive smoothing and reduced ability to capture sharp gradients. Despite these differences, neural networks enable significantly faster inference, achieving approximately 6.6× acceleration relative to the GPU-accelerated FVM. The computational advantage becomes most relevant in multi-execution scenarios such as parametric studies, sensitivity analyses, and inverse problems.Thiago E. Fernandes; Rodrigo W. dos Santos; Marcelo Lobosco

Artificial neural network; Sensitivity (control systems); Parametric statistics; Smoothing; Computational model; Inverse; Acceleration; Inverse problem; Computer science; Artificial intelligence; Machine learning; Volume (thermodynamics); Algorithm; Parametric model; Computational complexity theory; Deep neural networks; Finite element method; Key (lock); Work (physics)

2026-06-01https://doi.org/10.5753/sbcas_estendido.2026.21588 20261Desenvolvimento de um Método e Software para Posicionamento Virtual de Eletrodos em Modelos Computacionais de ECG Baseados em Ressonância MagnéticaO posicionamento virtual preciso dos eletrodos é etapa fundamental em modelos computacionais de ECG. Neste trabalho, apresentamos um método e uma ferramenta interativa para o posicionamento de eletrodos precordiais (V1–V6) em malhas tridimensionais de tórax derivadas de ressonância magnética. O fluxo proposto integra registro de marcos anatômicos, visualização de malhas e ajuste manual em um ambiente unificado. Como demonstração de aplicação, avaliamos o impacto do posicionamento comparando um pipeline automatizado com uma estratégia guiada por especialista em quatro pacientes com cardiomiopatia dilatada. Utilizando uma mesma malha cardíaca e o modelo monodomínio, foram gerados pseudo-ECGs analisados por meio de distância Euclidiana, correlação de Pearson e erro quadrático médio relativo (rRMSE). Os resultados indicam que diferenças geométricas, especialmente em eletrodos laterais, podem produzir alterações não uniformes na morfologia e amplitude dos sinais simulados, reforçando a importância do posicionamento virtual anatomicamente consistente em fluxos computacionais de ECG.MATHEUS CARDOSO FAESY; Thaís de Jesus Soares; Joventino de Oliveira Campos; Rodrigo Weber dos Santos

Pipeline (software); Virtual model; Amplitude; Software; Physics; Computer science; Humanities; Simulation

2026-06-01https://doi.org/10.5753/sbcas_estendido.2026.21702 20261Modelagem Computacional do Acúmulo e Migração de Proteínas no SNC no Contexto de EpilepsiaEste trabalho apresenta uma proposta de modelo computacional para descrever a transferência inter-regional da proteína tau hiperfosforilada (p-Tau) entre o córtex entorrinal e o giro dentado. O modelo apresenta populações microgliais com diferentes eficiências fagocíticas e inclui um termo de transferência modulado pela atividade microglial e por mecanismos associados a exossomos. São considerados dois cenários microgliais distintos, representando microglias mais e menos eficientes. Simulações numéricas são realizadas para analisar a evolução temporal da p-Tau e das populações microgliais, bem como a propagação direcional da proteína patológica entre as regiões.Letícia Ribeiro; Eliana Toscano; Marcelo Lobosco; Barbara M Quintela

Epilepsy; Electroencephalography; Neuroimaging; Context (archaeology); Psychology; Neuroscience; Computer science

2026-06-01https://doi.org/10.5753/sbcas_estendido.2026.20396 20261MyoMesh: Um Pipeline 3D Open-Source para Geração de Modelos Cardíacos PersonalizadosEste trabalho descreve um pipeline computacional tridimensional open-source em Python para geração de modelos cardíacos personalizados voltados à simulação eletrofisiológica. A partir de segmentações em ressonância magnética cardíaca, o método reconstrói a geometria biventricular, gera uma malha volumétrica tetraédrica com fronteiras anatômicas rotuladas e incorpora fibrose miocárdica em core e gray zone por marcação volumétrica hierárquica. Além disso, estima a orientação de fibras por elemento por uma abordagem rule-based baseada em campos elípticos. O resultado é um modelo completo, com rótulos teciduais e microestrutura, pronto para uso em simulações eletrofisiológicas.Filipe De Lima Namorato; Rodrigo Weber dos Santos; Joventino de Oliveira Campos

Python (programming language); Pipeline (software); Work (physics); Computation; Computer science; Engineering drawing; Engineering

2026-06-01https://doi.org/10.5753/sbcas_estendido.2026.21532 20261Do Complexo ao Mínimo: Otimização de Parâmetros para Reprodução Eficiente de Curvas de Restituição e do Potencial de AçãoModelos cardíacos complexos como o ToR-ORd são essenciais para pesquisa em arritmias, mas impõem alto custo computacional. Neste trabalho, o modelo fenomenológico de quatro variáveis de Bueno-Orovio foi otimizado para replicar o comportamento eletrofisiológico do modelo ToR-ORd de 44 variáveis, com foco na duração do potencial de ação (APD90), velocidade máxima de subida (max dV/dt) e morfologia da forma de onda. Uma análise de sensibilidade global pelo método de Sobol identificou os 13 parâmetros mais influentes. O algoritmo NSGA-II foi empregado para minimizar simultaneamente três objetivos conflitantes. O modelo calibrado obteve redução de 11 vezes na complexidade computacional e aceleração de 25 vezes no tempo de simulação, com erros normalizados de 2,7%, 1,1% e 3,5% para APD90, max dV/dt e morfologia.Mayra Urbieta Barbosa; Joventino O. Campos; Rodrigo W. dos Santos

Sobol sequence; Work (physics); Uncertainty quantification; Mathematical model; Variable (mathematics); Physics; Thermodynamics; Applied mathematics

2026-06-01https://doi.org/10.5753/sbcas_estendido.2026.20401 20261Ptose palpebral na síndrome de Kearns-SayreRESUMO O objetivo foi relatar um caso de ptose palpebral severa associada à síndrome de Kearns-Sayre, com seguimento de 12 anos após cirurgia corretiva. A paciente tinha diagnóstico clínico de síndrome de Kearns-Sayre, apresentando ptose palpebral progressiva desde a infância, tendo sido submetida à suspensão frontal bilateral com fio de silicone. O acompanhamento clínico incluiu avaliação da simetria palpebral, motilidade ocular e acuidade visual. Após 12 anos de seguimento, observaram-se manutenção da simetria palpebral e resultados funcionais satisfatórios, mesmo diante [...]Cristiana de Moraes Ramalho; Theo Ramalho Morais; Nicole Braghantini Larivoir; Guilherme Rufino Marques Pellegrin

Palpebral fissure; Eye disease; Dacryocystorhinostomy; Eyelid Diseases; Medicine; Gynecology; Ophthalmology

2026-01-01https://doi.org/10.37039/1982.8551.20260073Revista Brasileira de Oftalmologia 20261Dubowitz syndrome palpebral ptosis: a case reportTo report a case of Dubowitz syndrome with eyelid ptosis in the right eye, successfully treated with surgical correction. A 9-year-old child, previously diagnosed with Dubowitz syndrome, presented with congenital ptosis in the right eye. Surgical correction of eyelid ptosis was performed. The postoperative outcome showed significant functional and aesthetic improvement, with satisfactory eyelid position and absence of complications. Dubowitz syndrome is a rare autosomal recessive disorder characterized by multiple congenital anomalies, including ophthalmologic manifestations such as eyelid ptosis. [...]Cristiana de Moraes Ramalho; Theo Ramalho Morais; Nicole Braghantini Larivoir; Guilherme Rufino Marques Pellegrin

Palpebral fissure; Ptosis; Eyelid; Eyelid Diseases; Congenital disorder; Medicine; Surgery; Anatomy

2026-01-01https://doi.org/10.37039/1982.8551.20260074Revista Brasileira de Oftalmologia 20261Microstructural and mechanical evaluation of cement composites incorporating furniture industry wood ash and sewage sludgeAbstract This study evaluated the microstructural and mechanical impacts of incorporating specific furniture industry wastes (Eucalyptus wood ash and sewage treatment plant sludge) as partial Portland cement replacements. Pastes and mortars were prepared with 5%, 10%, 25%, and 50% substitution levels of either residue. A comprehensive methodology was applied, correlating macroscopic performance (workability, compressive strength) with continuous hydration kinetics (calorimetry, Ultrasonic Pulse Velocity) and microstructural evolution (SEM, XRD, FTIR). Results demonstrated that replacing 5% of cement with wood ash increased compressive strength by up to 28% compared to the reference series, driven by enhanced C-S-H formation. However, 50% ash substitution caused a 73% strength reduction, primarily attributed to a dilution effect, as the ash particles lacked the fineness required for a physical filler effect. Regarding the sewage sludge, low dosages (up to 10%) acted as a set retarder without significantly hindering overall hydration. Conversely, high sludge levels (50%) led to a severe loss of workability and an 85% drop in strength. Microstructural analyses revealed that the sludge's highly porous morphology and elevated organic content absorbed free water, critically inhibiting cement hydration.Roziani Maria Gomes; José Maria Franco de Carvalho; Gustavo Henrique Nalon; Pedro Henrique Rodrigues Fialho; Antônio Cléber Gonçalves Tibiriçá; José Carlos Lopes Ribeiro; Guilherme Jorge Brigolini Silva; Rancés Castillo Lara

Compressive strength; Cement; Fineness; Portland cement; Mortar; Porosity; Filler (materials); Materials science; Composite material; Sewage sludge; Waste management; Molding (decorative); Absorption of water; Dilution; Pulp and paper industry

2026-01-01https://doi.org/10.1590/s1983-41952026000100019Revista IBRACON de Estruturas e Materiais 20261Competência cultural em saúde: estudo com profissionais de quatro regiões do BrasilResumo Objetivou-se analisar a associação entre competência cultural e características sociodemográficas entre profissionais de saúde no Brasil. Trata-se de um estudo exploratório e correlacional, em amostra de conveniência não-probabilística de quatro regiões do país. Foram selecionados 213 participantes, predominantemente mulheres (73,7%), com média de idade de 37,9 anos (DP=10,4) e média de tempo de atuação de 11.2 anos (DP=9,2), de seis Unidades da Federação (Ceará, Distrito Federal, Minas Gerais, Piauí, Rio Grande do Norte e Rio Grande do Sul) e com os/as quais foram aplicados dois instrumentos: questionário sociodemográfico e escala EMCC14-BR. Para se estabelecer a associação de variáveis, foram realizadas análises bivariadas (Qui-Quadrado, Teste t, ANOVA) e posteriormente Análise de Regressão Logística. No modelo de associação final, encontrou-se que a formação universitária (OR=2,15; IC=1,16-2,15) e na área de Humanas e Sociais (OR=3,08; IC=1,41-6,72) estão relacionadas a maior competência cultural. Assim, os achados indicam a importância da formação voltada para os/as profissionais como parte das estratégias de educação permanente em saúde, possibilitando práticas de cuidado culturalmente sensíveis. Tendo em vista as limitações da amostragem por conveniência, recomenda-se que futuras pesquisas explorem, com amostras probabilísticas e recortes regionais mais equilibrados, os determinantes contextuais da competência cultural, ampliando a compreensão das desigualdades no cuidado em saúde no Brasil.Magda DIMENSTEIN; Telmo Mota RONZANI; João Paulo Sales Macedo; Jáder Ferreira Leite; Simone Mainieri PAULON; Maria Ines Gandolfo CONCEIÇÃO; Mariana Tavares Cavalcanti Liberato

Sample (material); Data collection; Exploratory research; Scale (ratio); Ethnic group; Test (biology); Socioeconomics; Medicine

2026-01-01http://pepsic.bvsalud.org/scielo.php?script=sci_arttext&pid=S1516-08582026000100611The portal of Electronic Journals of Psychology (Institute of Psychology of USP) 20261AS CLÍNICAS PÚBLICAS DE FREUD: UMA PROPOSTA PARA SUPERAÇÃO DO ELITISMO CLÍNICORESUMO: Agravado pela desigualdade social, o Brasil obtém o terceiro pior índice de saúde mental do mundo. A práxis psicanalítica pode ser uma forma de encontrar tratamento para o sofrimento gestado pelo e no sistema neoliberal. Todavia, seus elevados custos limitam, por vezes, seu acesso às elites econômicas, perpetuando a desigualdade social brasileira. Assim, é fundamental pensar em novas formas de acesso às populações marginalizadas a dispositivos clínicos. Essa constatação, apesar de revolucionária, não é nova, em 1918, Freud já defendia a popularização do seu acesso, incentivando a criação de 12 clínicas gratuitas na Europa. Essas experiências de sucesso, porém, foram silenciadas e deslegitimadas pela sistemática elitização da psicanálise. Essa pesquisa bibliográfica analisa os ecos da referida constatação no Brasil, destacando as experiências psicanalíticas que, implicadas na mitigação do sofrimento sociopolítico causado pelo mal-estar neoliberal, reivindicam o posto institucionalmente recalcado da psicanálise enquanto um potente agente de transformação social.Caio de Alencar Mendes Silveira; Bruno Quintino de Oliveira

Order (exchange); Power (physics); Work (physics); Production (economics); Noise (video); Philosophy; Psychology; Humanities

2026-01-01http://pepsic.bvsalud.org/scielo.php?script=sci_arttext&pid=S1519-549X2026000101002The portal of Electronic Journals of Psychology (Institute of Psychology of USP) 20261Conformidade dos procedimentos operacionais padrão para movimentação de pacientes em hospitais universitários: avaliação do trabalho prescritoResumo Objetivo Analisar o trabalho prescrito relacionado com tarefas de transporte e movimentação manual de pacientes. Métodos Foram realizadas as três etapas de análise de conteúdo: 1) pré-análise; 2) exploração do material; 3) tratamento dos resultados e interpretação. A busca dos Procedimentos Operacionais Padrão (POPs) foi realizada nos portais dos Hospitais Universitários (HUs) e por meio de mensagem de correio eletrônico. Foram analisados 33 POPs dos HUs administrados pela Empresa Brasileira de Serviços Hospitalares (EBSERH). A interpretação foi baseada nas exigências da Consolidação das Leis do Trabalho, Normas Regulamentadoras 17 e 32 e Resolução da Diretoria Colegiada nº 63 da Agência Nacional de Vigilância Sanitária. Resultados A análise desenvolveu 55 associações ou equivalências com os requisitos normativos em 20 POPs (60,6% dos documentos). Os itens mais frequentes foram relacionados com a recomendação para o trabalho em equipe, organização do ambiente, uso de meios técnicos facilitadores, uso de uma “mecânica corporal correta” e estímulo para a cooperação do paciente. Por outro lado, dos itens normativos considerados, seis não foram atendidos por nenhum dos POPs. Conclusão O estudo identificou um conteúdo heterogêneo do trabalho prescrito e omissão no atendimento a alguns requisitos relacionados com o transporte e movimentação de cargas.Geyson Fernando de Lima Batista; Peterson Marco de Oliveira Andrade

Work (physics); MEDLINE; Process (computing); Computer science; Engineering; Operations management

2026-01-01https://doi.org/10.1590/2317-6369/05125pt2026v51e20Revista Brasileira de Saúde Ocupacional 20261Elementos da educação nutricional para pessoas com diabetes na atenção primária: uma revisão de escopoRESUMO Objetivo: Mapear os elementos para o planejamento, a execução/engajamento e o monitoramento da educação nutricional voltada a pessoas com diabetes mellitus na Atenção Primária à Saúde. Método: Revisão de escopo, conforme as diretrizes do JBI. As buscas foram realizadas em bases de dados (LILACS, BDENF, MEDLINE, Cochrane, Scopus, Web of Science, EMBASE) e em fontes de literatura cinzenta (Google Acadêmico, BDTD/CAPES, Canadian-Theses-Portal, DiVA, RCAAP, OATD, WHO), com o rastreamento final em 04 de maio de 2025. A seleção dos estudos foi realizada por duplas de revisores de forma independente e cega, e a análise dos dados por categorização temática indutiva. Resultados: Incluíram-se 21 estudos, predominantemente em inglês, de países de médio/alto nível socioeconômico e com delineamentos experimentais. A análise definiu três categorias (planejamento, execução/engajamento, monitoramento) e oito dimensões, salientando envolvimento comunitário, adaptação cultural, metodologias ativas e acompanhamento. Lacunas persistem sobre diabetes tipo 1, monitoramento de longo prazo e pesquisas em países de baixo desenvolvimento econômico. Conclusão: os resultados reforçam a centralidade das abordagens educativas culturalmente sensíveis, interativas e interdisciplinares que considerem as especificidades culturais, sociais e emocionais da população atendida, promovendo o protagonismo dos indivíduos no processo de autocuidado.Fábio da Costa Carbogim; Adriana Melo Bothomé; Amanda Damasceno de Souza; André Luiz Silva Alvim; Elaine da Silva Lopes; Giovana Caetano de Araujo Laguardia; Carolina Alves Matos de Menezes; Vilanice Alves de Araújo Püschel

Diabetes mellitus; Context (archaeology); Type 1 diabetes; Qualitative research; Medicine; Gerontology

2026-01-01https://doi.org/10.1590/1983-1447.2026.20250289.ptRevista gaúcha de enfermagem 20261Elements of nutrition education for people with diabetes in primary care: a scoping reviewABSTRACT Objective: To map the elements for the planning, implementation/engagement, and monitoring of nutrition education aimed at people with diabetes mellitus in Primary Health Care. Method: A scoping review was conducted according to JBI guidelines. Searches were performed in databases (LILACS, BDENF, MEDLINE, Cochrane, Scopus, Web of Science, EMBASE) and grey literature sources (Google Scholar, BDTD/CAPES, Canadian-Theses-Portal, DiVA, RCAAP, OATD, WHO), with final tracking on May 4, 2025. Study selection was performed by reviewer pairs, independently and blindly, and data analysis by inductive thematic categorization. Results: Twenty-one studies were included, predominantly in English, from middle/high-income countries, and with experimental designs. The analysis defined three categories (planning, implementation/engagement, monitoring) and eight dimensions, highlighting community involvement, cultural adaptation, active methodologies, and continuous follow-up. Gaps persist in type 1 diabetes, long-term monitoring, and research in low-income countries. Conclusion: The findings reinforce the centrality of culturally sensitive, interactive, and interdisciplinary educational approaches that consider the cultural, social, and emotional specificities of the population served, promoting the protagonism of individuals in the self-care process.Fábio da Costa Carbogim; Adriana Melo Bothomé; Amanda Damasceno de Souza; André Luiz Silva Alvim; Elaine da Silva Lopes; Giovana Caetano de Araujo Laguardia; Carolina Alves Matos de Menezes; Vilanice Alves de Araújo Püschel

Thematic analysis; Centrality; Grey literature; Tracking (education); Population; Nutrition Education; Selection (genetic algorithm); Qualitative research; Culturally appropriate; Medicine; Gerontology; Medical education; Nursing; Health professionals

2026-01-01https://doi.org/10.1590/1983-1447.2026.20250289.enRevista gaúcha de enfermagem 20261Efetividade de intervenção educativa gamificada na higienização das mãos entre profissionais de enfermagem: estudo quase-experimentalObjetivo: avaliar a efetividade de uma intervenção educativa gamificada na execução correta da técnica de higienização das mãos entre enfermeiros e técnicos de enfermagem em unidades de internação hospitalar. Método: trata-se de um estudo quase-experimental, do tipo antes e depois, conduzido com 45 profissionais de enfermagem. A coleta de dados foi realizada por meio de um formulário estruturado para a observação da técnica nos períodos pré e pós-intervenção. A análise estatística dos dados foi realizada utilizando o teste de Wilcoxon Signed-Rank e o teste de McNemar. Resultados: no período pré-intervenção, 61,3% dos técnicos e 42,9% dos enfermeiros não seguiam todos os passos da técnica; após a gamificação, 100% dos enfermeiros e 97,7% dos técnicos de enfermagem realizaram os passos corretos (p<0,001), com redução no número de etapas esquecidas (z= 4,532, p<0,001, r=0,81). O tempo de execução também foi adequado após a intervenção, seguindo as recomendações da Organização Mundial da Saúde (z=-2,441, p=0,015, r=0,36). Conclusão: a intervenção educativa gamificada foi efetiva na execução correta da técnica de higienização das mãos entre enfermeiros e técnicos de enfermagem, reduzindo erros e aumentando a conformidade com as diretrizes internacionais.Maiara Luci Silva Costa; Márcio Medeiros; Fábio da Costa Carbogim; Thiago César Nascimento; André Luiz Silva Alvim

Data collection; Test (biology); Nursing care; MEDLINE; Medicine; Psychology

2026-01-01https://doi.org/10.1590/1518-8345.8067.4892Revista Latino-Americana de Enfermagem 20261AS PRÁTICAS ELEITORAIS NO IMPÉRIO DO BRASIL: O VOTO, AS INSTRUÇÕES ELEITORAIS E AS QUEIXAS NA CULTURA DO VOTO (MINAS GERAIS 1824-1831)Resumo O presente artigo tem como objetivo central discorrer sobre a historiografia das eleições, bem como sobre as primeiras instruções eleitorais para eleições a nível municipal do Brasil oitocentista. Para isso, o texto recorre a fontes de comunicação política, como queixas enviadas a autoridades provinciais, para demonstrar que a disputa eleitoral ocorria para além do momento eleitoral. Essas queixas, muitas vezes dirigidas contra autoridades eleitorais, revelam o exercício de cidadania e o uso de instrumentos peticionários na cultura do voto do Brasil Imperial. O estudo toma como base fontes da província de Minas Gerais para mostrar as práticas eleitorais no início do constitucionalismo brasileiro.Érica da Cruz Rosa

Work (physics); Base (topology); Public policy; Political science

2026-01-01https://doi.org/10.1590/2236-463340ec21955Almanack 20261NUTRITION MANAGEMENT OF INFLAMMATORY BOWEL DISEASES: A CONSENSUS OF THE BRAZILIAN ORGANIZATION FOR CROHN’S AND COLITIS (GEDIIB)ABSTRACT Background: Inflammatory bowel diseases (IBD), specifically Crohn’s disease and ulcerative colitis, are multifactorial conditions. Genetic and behavioral factors are associated with disease development and influence its progression. It is known that diet plays a role in this pathogenic process. Objective: to position nutritional and dietary factors in the management of IBD. Methods: This consensus was developed by nutritionists, gastroenterologists, and colorectal surgeons, members of GEDIIB (Brazilian Organization for Crohn’s disease and colitis). A systematic review of the most recent evidence was conducted to support the recommendations/statements. All recommendations and statements were endorsed by stakeholders and IBD experts in a modified Delphi panel, achieving a consensus rate of at least 80%. Results and conclusion: the recommendations were directed according to disease activity and severity. Nutritional screening and diagnosis, nutritional therapy in the active and remission phases of the disease, dietary management and exclusion diets, and supplementation were addressed. The consensus is targeted at nutritionists, general practitioners, gastroenterologists, and surgeons interested in managing adults with IBD. It supports decision-making by health insurance companies, regulatory agencies, and health institutional managers.Daniéla Oliveira MAGRO; Carina ROSSONI; Raquel Rocha; Ligia Yukie SASSAKI; Marcello IMBRIZI; Isadora Sayuri Macedo TUMA; Carina Andriatta BLUME; Cristina Henschel MATOS; Ryan Nunes Yoshio YOSHIHARA; Maria Izabel Lamounier de VASCONCELOS; Patricia Hanako Ribeiro SATO; Maria Paula Carlin CAMBI; Claiza Barretta LA BELLA; Matheus Freitas Cardoso de AZEVEDO; Julio Maria Fonseca CHEBLI; Cristiane Kibune NAGASAKO; Júlio Pinheiro BAIMA; Claudio Saddy Rodrigues COY; Paulo Gustavo KOTZE; Cristina FLORES; Rogério SAAD-HOSSNE; Eduardo Garcia VILELA

Inflammatory bowel disease; Ulcerative colitis; Medical nutrition therapy; Disease; Delphi method; Consensus conference; Disease management; Position paper; Medicine; Inflammatory Bowel Diseases; Intensive care medicine; Dietary management; MEDLINE; Crohn's disease; Family medicine; Internal medicine

2026-01-01https://doi.org/10.1590/s0004-2803.24612026-042Arquivos de Gastroenterologia 20261VTH BRAZILIAN CONSENSUS CONFERENCE ON HELICOBACTER PYLORI INFECTIONABSTRACT Background: Helicobacter pylori infection remains highly prevalent, affecting approximately 40% of the global population. Individuals with infection continue to be at risk for its various clinical consequences, including chronic gastritis, peptic ulcer disease, and gastric cancer. Objective: The Brazilian Helicobacter pylori and Microbiota Study Group and the Brazilian Federation of Gastroenterology present the Fifth Brazilian Consensus on this topic, following the inaugural edition in 1995. Significant advances across various areas have emerged since the publication of the last consensus in 2018. These advances are particularly relevant to bacterial eradication, as treatment encounters mounting challenges due to rising antimicrobial resistance. Methods: For this update, five working groups were established to address: 1) epidemiology; 2) associated diseases and treatment indications; 3) diagnosis; 4) gastric cancer; and 5) treatment and microbiota. Conclusion: The groups developed 34 evidence-based recommendations to guide clinicians in managing this infection within the Brazilian population.Luiz Gonzaga Vaz COELHO; Bruno Squárcio Fernandes SANCHES; Ismael MAGUILNIK; James Ramalho MARINHO; Sandro Rodrigues CHAVES; Ana Flávia P. RAMOS; Heinrich SEIDLER; Ricardo C. BARBUTI; Renato S. LABOISSIÈRE; Laércio Tenório RIBEIRO; Maria do Carmo F. PASSOS; Julio César de Soares VELOSO; Lucia Libanês C. BRAGA; Frederico Passos MARINHO; Helenice P. BREYER; Hoiti OKAMOTO; Jardel Soares CAETANO; Paulo Pimentel D’ASSUMPÇÃO; Leonardo Soares da SILVA; Gerson DOMINGUES; Raul Carlos WAHLE; Eliza Maria de BRITO; Marcela Tavares da Rocha LOURES; Joaquim Prado MORAES-FILHO; Décio CHINZON; Áureo Almeida DELGADO

Helicobacter pylori infection; Helicobacter pylori; Consensus conference; Peptic ulcer; Helicobacter; Helicobacter Infections; Clinical Practice; Medicine; Internal medicine; Intensive care medicine; Immunology; Antimicrobial; Chronic infection; Peptic

2026-01-01https://doi.org/10.1590/s0004-2803.24612026-043Arquivos de Gastroenterologia 20261Effectiveness of a gamified educational intervention on hand hygiene among Nursing professionals: a quasi-experimental studyObjective: to assess the effectiveness of a gamified educational intervention on proper execution of the hand hygiene technique among nurses and nursing technicians in hospitalization units. Method: this quasi-experimental study of the before-and-after type was conducted with 45 Nursing professionals. The data were collected by means of a structured form to observe the technique before and after the intervention. The statistical data analysis was performed using Wilcoxon’s Signed-Rank test and the McNemar test. Results: in the pre-intervention period, 61.3% of the technicians and 42.9% of the nurses failed to follow all the technique steps; after the gamification, 100% of the nurses and 97.7% of the nursing technicians did implement the right steps (p<0.001) and forgot fewer stages (z=-4.532, p<0.001, r=0.81). The time to perform the technique was also adequate after the intervention, following the recommendations set forth by the World Health Organization (z=-2.441, p=0.015, r=0.36). Conclusion: the gamified educational intervention was effective in proper execution of the hand hygiene technique among nurses and nursing technicians, reducing errors and increasing compliance with the international guidelines.Maiara Luci Silva Costa; Márcio Medeiros; Fábio da Costa Carbogim; Thiago César Nascimento; André Luiz Silva Alvim

McNemar's test; Hygiene; Intervention (counseling); Test (biology); Nurse education; Hand washing; Nursing Outcomes Classification; Certification; Nursing; Medicine; Set (abstract data type); Nursing Assistant

2026-01-01https://doi.org/10.1590/1518-8345.8067.4891Revista Latino-Americana de Enfermagem 20261Efectividad de una intervención educativa gamificada sobre el lavado de manos entre profesionales de Enfermería: estudio cuasiexperimentalObjetivo: evaluar la efectividad de una intervención educativa gamificada en la correcta ejecución de la técnica del lavado de manos entre enfermeros y técnicos de enfermería que trabajan en unidades de internación hospitalaria. Método: estudio cuasiexperimental del tipo antes y después, realizado con 45 profesionales de Enfermería. Los datos se recolectaron por medio de un formulario estructurado para observar la técnica en los períodos Pre- y Post-intervención. El análisis estadístico de los datos se realizó utilizando la prueba Signed-Rank de Wilcoxon y la prueba de McNemar. Resultados: durante el período Pre-intervención, el 61,3% de los técnicos y el 42,9% de los enfermeros no siguieron todos los pasos de la técnica; después de la gamificación, el 100% de los enfermeros y el 97,7% de los técnicos de enfermería implementaron los pasos correctos (p<0.001) y olvidaron menos etapas (z=-4,532; p<0,001; r=0,81). El tiempo dedicado a ejecutar la técnica también fue adecuado después de la intervención, siguiendo las recomendaciones de la Organización Mundial de la Salud (z=-2,441; p=0,015; r=0,36). Conclusión: la intervención educativa gamificada fue efectiva en la correcta ejecución de la técnica del Lavado de manos entre enfermeros y técnicos de enfermería, reduciendo la cantidad de errores y mejorando el cumplimiento de las pautas internacionales.Maiara Luci Silva Costa; Márcio Medeiros; Fábio da Costa Carbogim; Thiago César Nascimento; André Luiz Silva Alvim

Initial training; Continuing education; Humanities; Philosophy

2026-01-01https://doi.org/10.1590/1518-8345.8067.4890Revista Latino-Americana de Enfermagem 20261Compliance of standard operating procedures for patient handling in university hospitals: assessment of prescribed workAbstract Objective To analyze the prescribed work related to patient transport and manual handling tasks. Methods The three stages of content analysis were carried out: 1) pre-analysis; 2) exploration of the material; 3) processing of results and interpretation. The search for Standard Operating Procedures (SOPs) was conducted on the websites of University Hospitals (UHs) and via email. A total of 33 SOPs from UHs administered by the Brazilian Hospital Services Company (EBSERH) were analyzed. The interpretation was based on the requirements of the Consolidation of Labor Laws, Regulatory Standards 17 and 32, and Resolution No. 63 of the Collegiate Board of the National Health Surveillance Agency. Results The analysis identified 55 associations or equivalences with regulatory requirements in 20 SOPs (60.6% of the documents). The most frequent items were related to recommendations for teamwork, workplace organization, use of technical aids, use of “proper body mechanics,” and encouragement of patient cooperation. On the other hand, of the regulatory items considered, six were not met by any of the SOPs. Conclusion The study identified heterogeneous content in the prescribed work and omissions in meeting certain requirements related to the transport and handling of loads.Geyson Fernando de Lima Batista; Peterson Marco de Oliveira Andrade

Work (physics); Consolidation (business); Compliance (psychology); Manual handling; Standard operating procedure; Health care; Operations management; Medical emergency; Medicine

2026-01-01https://doi.org/10.1590/2317-6369/05125en2026v51e20Revista Brasileira de Saúde Ocupacional